Dianne Newbury, March 15
Genetic investigations of speech and language disorders
Wellcome Trust Centre for Human Genetics, Oxford University
Developmental language disorders are common in school-age children and account for a high proportion of statements of special education needs and paediatric referrals. In cases where these language impairments represent the primary medical concern and are not accompanied by other developmental conditions or neurological disorders (such as autism or intellectual disability), a diagnosis of Specific Language Impairment (SLI) is made. It is estimated that SLI affects between 5 and 7% of English-speaking preschool children, and is highly heritable. Recent studies have begun to identify genetic factors which may play a role in susceptibility to SLI. In particular, a targeted screen of chromosome 16q identified specific genetic variations that were significantly associated with performance on a measure of verbal short-term memory allowing the identification of two candidate genes; ATP2C2, a calcium ATPase and C-MIP, a cellular signalling protein. In this talk, I will outline the genetic techniques that can be applied to the study of language disorders and provide an overview of studies in this field.
- Where and when:
15:45-17:00 Mar 15, 2011MPI Nijmegen, Room 163