Martin Becker to defend thesis on understanding the regulation of the FOXP2 gene in the brain
The FOXP2 gene regulates the switching on and off of many other genes. It does so in neurons that form the neuronal circuits underlying speech and language, and mutations that change the FOXP2 protein cause problems in the development of speech. Investigating the genes that are switched on or off by FOXP2 increases our understanding of the molecular mechanisms that underlie neuronal development.
Martin Becker took another angle and studied how the FOXP2 gene itself is switched on in neurons. Using the three-dimensional structure of DNA in living cells, he identified genomic regions that enhance the production of FOXP2 and characterized their activity in cultured neurons and the brains of mice.
Martin Becker identified multiple DNA elements, called enhancers, that may regulate the FOXP2 gene in the developing brain. Importantly, he saw that in a child with speech impairment a genetic rearrangement would remove enhancers from the gene, which may consequently impair the production of FOXP2 in some neurons. Becker further discovered that the activity of some enhancers is increased in the presence of the FOXP2 protein, suggesting that FOXP2 potentially increases the production of its own protein product. As this process occurs on enhancers active in the brain, it may explain why individuals with a mutated FOXP2 protein show neuronal deficits but have no problems with other organs that produce this protein. In summary, Becker’s findings reveal molecular mechanisms involved in the regulation of FOXP2 and may aid the identification of this gene’s role in typical and atypical neurodevelopment.
- Martin Becker will defend his thesis on Wednesday, October 26 at 16:30 in the Aula of the Radboud University
- The thesis appears in the MPI Series (no 112).