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Pamela Perniss studied General Linguistics and Comparative Literature at the Eberhard Karls Universität Tübingen and the Universität zu Köln, and obtained an MA in Linguistics at the Universität zu Köln. Her PhD research was carried at the Max Planck Institute for Psycholinguistics, Nijmegen, culminating in dissertation on "Space and Iconicity in German Sign Language (DGS)".
She is currently involved in the NWO-funded VIDI project "Relations between modality and language structure: Insights from comparisons of sign languages and gestures" (PI Asli Ozyurek) at the Radboud University Nijmegen and the MPI for Psycholinguistics.