Publications

Abstract

The present study investigated whether speech-related spectral information benefits from initially predominant right or left hemisphere processing. Normal hearing individuals categorized speech sounds composed of an ambiguous base (perceptually intermediate between /ga/ and /da/), presented to one ear, and a disambiguating low or high F3 chirp presented to the other ear. Shorter response times were found when the chirp was presented to the left ear than to the right ear (inducing initially right-hemisphere chirp processing), but no between-ear differences in strength of overall integration. The results are in line with the assumptions of a right hemispheric dominance for spectral processing.

Abstract

The field of psycholinguistics is currently experiencing an explosion of interest in the analysis of neural oscillations—rhythmic brain activity synchronized at different temporal and spatial levels. Given that language comprehension relies on a myriad of processes, which are carried out in parallel in distributed brain networks, there is hope that this methodology might bring the field closer to understanding some of the more basic (spatially and temporally distributed, yet at the same time often overlapping) neural computations that support language function. In this review, we discuss existing proposals linking oscillatory dynamics in different frequency bands to basic neural computations and review relevant theories suggesting associations between band-specific oscillations and higher-level cognitive processes. More or less consistent patterns of oscillatory activity related to certain types of linguistic processing can already be derived from the evidence that has accumulated over the past few decades. The centerpiece of the current review is a synthesis of such patterns grouped by linguistic phenomenon. We restrict our review to evidence linking measures of oscillatory
power to the comprehension of sentences, as well as linguistically (and/or pragmatically) more complex structures. For each grouping, we provide a brief summary and a table of associated oscillatory signatures that a psycholinguist might expect to find when employing a particular linguistic task. Summarizing across different paradigms, we conclude that a handful of basic neural oscillatory mechanisms are likely recruited in different ways and at different times for carrying out a variety of linguistic computations.

Abstract

Symbolic play has long been considered a fertile context for communicative development (Bruner, 1983, Child's talk: Learning to use language, Oxford University Press, Oxford; Vygotsky, 1962, Thought and language, MIT Press, Cambridge, MA; Vygotsky, 1978, Mind in society: The development of higher psychological processes. Harvard University Press, Cambridge, MA). In the current study, we examined caregiver–infant interaction during symbolic play and compared it to interaction in a comparable but non‐symbolic context (i.e., ‘functional’ play). Fifty‐four (N = 54) caregivers and their 18‐month‐old infants were observed engaging in 20 min of play (symbolic, functional). Play interactions were coded and compared across play conditions for joint attention (JA) and gesture use. Compared with functional play, symbolic play was characterized by greater frequency and duration of JA and greater gesture use, particularly the use of iconic gestures with an object in hand. The results suggest that symbolic play provides a rich context for the exchange and negotiation of meaning, and thus may contribute to the development of important skills underlying communicative development.

Abstract

Phosphoglucomutase 1 (PGM1) encodes the metabolic enzyme that interconverts glucose-6-P and glucose-1-P. Mutations in PGM1 cause impairment in glycogen metabolism and glycosylation, the latter manifesting as a congenital disorder of glycosylation (CDG). This unique metabolic defect leads to abnormal N-glycan synthesis in the endoplasmic reticulum (ER) and the Golgi apparatus (GA). On the basis of the decreased galactosylation in glycan chains, galactose was administered to individuals with PGM1-CDG and was shown to markedly reverse most disease-related laboratory abnormalities. The disease and treatment mechanisms, however, have remained largely elusive. Here, we confirm the clinical benefit of galactose supplementation in PGM1-CDG-affected individuals and obtain significant insights into the functional and biochemical regulation of glycosylation. We report here that, by using tracer-based metabolomics, we found that galactose treatment of PGM1-CDG fibroblasts metabolically re-wires their sugar metabolism, and as such replenishes the depleted levels of galactose-1-P, as well as the levels of UDP-glucose and UDP-galactose, the nucleotide sugars that are required for ER- and GA-linked glycosylation, respectively. To this end, we further show that the galactose in UDP-galactose is incorporated into mature, de novo glycans. Our results also allude to the potential of monosaccharide therapy for several other CDG.

Abstract

Automatic word count estimation (WCE) from audio recordings can be used to quantify the amount of verbal communication in a recording environment. One key application of WCE is to measure language input heard by infants and toddlers in their natural environments, as captured by daylong recordings from microphones worn by the infants. Although WCE is nearly trivial for high-quality signals in high-resource languages, daylong recordings are substantially more challenging due to the unconstrained acoustic environments and the presence of near- and far-field speech. Moreover, many use cases of interest involve languages for which reliable ASR systems or even well-defined lexicons are not available. A good WCE system should also perform similarly for low- and high-resource languages in order to enable unbiased comparisons across different cultures and environments. Unfortunately, the current state-of-the-art solution, the LENA system, is based on proprietary software and has only been optimized for American English, limiting its applicability. In this paper, we build on existing work on WCE and present the steps we have taken towards a freely available system for WCE that can be adapted to different languages or dialects with a limited amount of orthographically transcribed speech data. Our system is based on language-independent syllabification of speech, followed by a language-dependent mapping from syllable counts (and a number of other acoustic features) to the corresponding word count estimates. We evaluate our system on samples from daylong infant recordings from six different corpora consisting of several languages and socioeconomic environments, all manually annotated with the same protocol to allow direct comparison. We compare a number of alternative techniques for the two key components in our system: speech activity detection and automatic syllabification of speech. As a result, we show that our system can reach relatively consistent WCE accuracy across multiple corpora and languages (with some limitations). In addition, the system outperforms LENA on three of the four corpora consisting of different varieties of English. We also demonstrate how an automatic neural network-based syllabifier, when trained on multiple languages, generalizes well to novel languages beyond the training data, outperforming two previously proposed unsupervised syllabifiers as a feature extractor for WCE.

Abstract

Time is one crucial dimension conveying information in animal communication. Evolution has shaped animals’ nervous systems to produce signals with temporal properties fitting their socio-ecological niches. Many quantitative models of mechanisms underlying rhythmic behaviour exist, spanning insects, crustaceans, birds, amphibians, and mammals. However, these computational and mathematical models are often presented in isolation. Here, we provide an overview of the main mathematical models employed in the study of animal rhythmic communication among conspecifics. After presenting basic definitions and mathematical formalisms, we discuss each individual model. These computational models are then compared using simulated data to uncover similarities and key differences in the underlying mechanisms found across species. Our review of the empirical literature is admittedly limited. We stress the need of using comparative computer simulations – both before and after animal experiments – to better understand animal timing in interaction. We hope this article will serve as a potential first step towards a common computational framework to describe temporal interactions in animals, including humans.

Abstract

The study of human language is progressively moving toward comparative and interactive frameworks, extending the concept of turn‐taking to animal communication. While such an endeavor will help us understand the interactive origins of language, any theoretical account for cross‐species turn‐taking should consider three key points. First, animal turn‐taking must incorporate biological studies on animal chorusing, namely how different species coordinate their signals over time. Second, while concepts employed in human communication and turn‐taking, such as intentionality, are still debated in animal behavior, lower level mechanisms with clear neurobiological bases can explain much of animal interactive behavior. Third, social behavior, interactivity, and cooperation can be orthogonal, and the alternation of animal signals need not be cooperative. Considering turn‐taking a subset of chorusing in the rhythmic dimension may avoid overinterpretation and enhance the comparability of future empirical work.

Abstract

Puppyhood is a very active social and vocal period in a harbor seal's life Phoca vitulina. An important feature of vocalizations is their temporal and rhythmic structure, and understanding vocal timing and rhythms in harbor seals is critical to a cross-species hypothesis in evolutionary neuroscience that links vocal learning, rhythm perception, and synchronization. This study utilized analytical techniques that may best capture rhythmic structure in pup vocalizations with the goal of examining whether (1) harbor seal pups show rhythmic structure in their calls and (2) rhythms evolve over time. Calls of 3 wild-born seal pups were recorded daily over the course of 1-3 weeks; 3 temporal features were analyzed using 3 complementary techniques. We identified temporal and rhythmic structure in pup calls across different time windows. The calls of harbor seal pups exhibit some degree of temporal and rhythmic organization, which evolves over puppyhood and resembles that of other species' interactive communication. We suggest next steps for investigating call structure in harbor seal pups and propose comparative hypotheses to test in other pinniped species.

Abstract

Comparative research investigating how nonhuman animals generalize patterns of auditory stimuli often uses sequences of human speech syllables and reports limited generalization abilities in animals. Here, we reverse this logic, testing humans with stimulus sequences tailored to squirrel monkeys. When test stimuli are familiar (human voices), humans succeed in two types of generalization. However, when the same structural rule is instantiated over unfamiliar but perceivable sounds within squirrel monkeys’ optimal hearing frequency range, human participants master only one type of generalization. These findings have methodological implications for the design of comparative experiments, which should be fair towards all tested species’ proclivities and limitations.

Abstract

Animal communication and motoric behavior develop over time. Often, this temporal dimension has communicative relevance and is organized according to structural patterns. In other words, time is a crucial dimension for rhythm and synchrony in animal movement and communication. Rhythm is defined as temporal structure at a second-millisecond time scale (Kotz et al. 2018). Synchrony is defined as precise co-occurrence of 2 behaviors in time (Ravignani 2017).

Rhythm, synchrony, and other forms of temporal interaction are taking center stage in animal behavior and communication. Several critical questions include, among others: what species show which rhythmic predispositions? How does a species’ sensitivity for, or proclivity towards, rhythm arise? What are the species-specific functions of rhythm and synchrony, and are there functional trends across species? How did similar or different rhythmic behaviors evolved in different species? This Special Column aims at collecting and contrasting research from different species, perceptual modalities, and empirical methods. The focus is on timing, rhythm and synchrony in the second-millisecond range.

Three main approaches are commonly adopted to study animal rhythms, with a focus on: 1) spontaneous individual rhythm production, 2) group rhythms, or 3) synchronization experiments. I concisely introduce them below (see also Kotz et al. 2018; Ravignani et al. 2018).

Abstract

Why does human speech have rhythm? As we cannot travel back in time to witness how speech developed its rhythmic properties and why humans have the cognitive skills to process them, we rely on alternative methods to find out. One powerful tool is the comparative approach: studying the presence or absence of cognitive/behavioral traits in other species to determine which traits are shared between species and which are recent human inventions. Vocalizations of many species exhibit temporal structure, but little is known about how these rhythmic structures evolved, are perceived and produced, their biological and developmental bases, and communicative functions. We review the literature on rhythm in speech and animal vocalizations as a first step toward understanding similarities and differences across species. We extend this review to quantitative techniques that are useful for computing rhythmic structure in acoustic sequences and hence facilitate cross‐species research. We report links between vocal perception and motor coordination and the differentiation of rhythm based on hierarchical temporal structure. While still far from a complete cross‐species perspective of speech rhythm, our review puts some pieces of the puzzle together.

Abstract

Alternative mathematical models predict differences in how animals adjust the timing of their calls. Differences can be measured as the effect of the timing of a conspecific call on the rate and period of calling of a focal animal, and the lag between the two. Here, I test these alternative hypotheses by tapping into harbor seals’ (Phoca vitulina) mechanisms for spontaneous timing. Both socioecology and vocal behavior of harbor seals make them an interesting model species to study call rhythm and timing. Here, a wild-born seal pup was tested in controlled laboratory conditions. Based on previous recordings of her vocalizations and those of others, I designed playback experiments adapted to that specific animal. The call onsets of the animal were measured as a function of tempo, rhythmic regularity, and spectral properties of the playbacks. The pup adapted the timing of her calls in response to conspecifics’ calls. Rather than responding at a fixed time delay, the pup adjusted her calls’ onset to occur at a fraction of the playback tempo, showing a relative-phase antisynchrony. Experimental results were confirmed via computational modeling. This case study lends preliminary support to a classic mathematical model of animal behavior—Hamilton’s selfish herd—in the acoustic domain.

Abstract

Understanding worldwide patterns of language diversity has long been a goal for evolutionary scientists, linguists and philosophers. Research over the past decade has suggested that linguistic diversity may result from differences in the social environments in which languages evolve. Specifically, recent work found that languages spoken in larger communities typically have more systematic grammatical structures. However, in the real world, community size is confounded with other social factors such as network structure and the number of second languages learners in the community, and it is often assumed that linguistic simplification is driven by these factors instead. Here, we show that in contrast to previous assumptions, community size has a unique and important influence on linguistic structure. We experimentally examine the live formation of new languages created in the laboratory by small and larger groups, and find that larger groups of interacting participants develop more systematic languages over time, and do so faster and more consistently than small groups. Small groups also vary more in their linguistic behaviours, suggesting that small communities are more vulnerable to drift. These results show that community size predicts patterns of language diversity, and suggest that an increase in community size might have contributed to language evolution.

Abstract

Experimental work in the field of language evolution has shown that novel signal systems become more structured over time. In a recent paper, Kirby, Tamariz, Cornish, and Smith (2015) argued that compositional languages can emerge only when languages are transmitted across multiple generations. In the current paper, we show that compositional languages can emerge in a closed community within a single generation. We conducted a communication experiment in which we tested the emergence of linguistic structure in different micro-societies of four participants, who interacted in alternating dyads using an artificial language to refer to novel meanings. Importantly, the communication included two real-world aspects of language acquisition and use, which introduce compressibility pressures: (a) multiple interaction partners and (b) an expanding meaning space. Our results show that languages become significantly more structured over time, with participants converging on shared, stable, and compositional lexicons. These findings indicate that new learners are not necessary for the formation of linguistic structure within a community, and have implications for related fields such as developing sign languages and creoles.

Abstract

Recognizing that two elements within a sequence of variable length depend on each other is a key ability in understanding the structure of language and music. Perception of such interdependencies has previously been documented in chimpanzees in the visual domain and in human infants and common squirrel monkeys with auditory playback experiments, but it remains unclear whether it typifies primates in general. Here, we investigated the ability of common marmosets (Callithrix jacchus) to recognize and respond to such dependencies. We tested subjects in a familiarization-discrimination playback experiment using stimuli composed of pure tones that either conformed or did not conform to a grammatical rule. After familiarization to sequences with dependencies, marmosets spontaneously discriminated between sequences containing and lacking dependencies (‘consistent’ and ‘inconsistent’, respectively), independent of stimulus length. Marmosets looked more often to the sound source when hearing sequences consistent with the familiarization stimuli, as previously found in human infants. Crucially, looks were coded automatically by computer software, avoiding human bias. Our results support the hypothesis that the ability to perceive dependencies at variable distances was already present in the common ancestor of all anthropoid primates (Simiiformes).

Abstract

In our interactions with people and objects in the world around us, as well as in communicating our thoughts, we
rely on the use of conceptual knowledge stored in long-term memory. From a frame-theoretic point of view, a
concept is represented by a central node and recursive attribute-value structures further specifying the concept.
The present study explores whether and how the activation of an attribute within a frame might influence access
to the concept's name in language production, focussing on the colour attribute. Colour has been shown to
contribute to object recognition, naming, and memory retrieval, and there is evidence that colour plays a different
role in naming objects that have a typical colour (high colour-diagnostic objects such as tomatoes) than in
naming objects without a typical colour (low colour-diagnostic objects such as bicycles). We report two behavioural
experiments designed to reveal potential effects of the activation of an object's typical colour on naming
the object in a picture-word interference paradigm. This paradigm was used to investigate whether naming is
facilitated when typical colours are presented alongside the to-be-named picture (e.g., the word “red” superimposed
on the picture of a tomato), compared to atypical colours (such as “brown”), unrelated adjectives (such
as “fast”), or random letter strings. To further explore the time course of these potential effects, the words were
presented at different time points relative to the to-be-named picture (Exp. 1: −400 ms, Exp. 2: −200 ms, 0 ms,
and+200 ms). By including both high and low colour-diagnostic objects, it was possible to explore whether the
activation of a colour differentially affects naming of objects that have a strong association with a typical colour.
The results showed that (pre-)activation of the appropriate colour attribute facilitated naming compared to an
inappropriate colour. This was only the case for objects closely connected with a typical colour. Consequences of
these findings for frame-theoretic accounts of conceptual representation are discussed.

Abstract

The objectives of this article are to characterize the performance and to discuss the performance differences between literate and illiterate participants in a well-defined study population.We describe the participant-selection procedure used to investigate this population. Three groups with similar sociocultural backgrounds living in a relatively homogeneous fishing community in southern Portugal were characterized in terms of socioeconomic and sociocultural background variables and compared on a simple neuropsychological test battery; specifically, a literate group with more than 4 years of education (n = 9), a literate group with 4 years of education (n = 26), and an illiterate group (n = 31) were included in this study.We compare and discuss our results with other similar studies on the effects of literacy and illiteracy. The results indicate that naming and identification of real objects, verbal fluency using ecologically relevant semantic criteria, verbal memory, and orientation are not affected by literacy or level of formal education. In contrast, verbal working memory assessed with digit span, verbal abstraction, long-term semantic memory, and calculation (i.e., multiplication) are significantly affected by the level of literacy. We indicate that it is possible, with proper participant-selection procedures, to exclude general cognitive impairment and to control important sociocultural factors that potentially could introduce bias when studying the specific effects of literacy and level of formal education on cognitive brain function.

Abstract

Is there a relation between socioeconomic factors and aphasia severity and recovery? Connor, Obler, Tocco, Fitzpatrick, and Albert (2001) describe correlations between the educational level and socioeconomic status of aphasic subjects with aphasia severity and subsequent recovery. As stated in the introduction by Connor et al. (2001), studies of the influence of educational level and literacy (or illiteracy) on aphasia severity have yielded conflicting results, while no significant link between socioeconomic status and aphasia severity and recovery has been established. In this brief note, we will comment on their findings and conclusions, beginning first with a brief review of literacy and aphasia research, and complexities encountered in these fields of investigation. This serves as a general background to our specific comments on Connor et al. (2001), which will be focusing on methodological issues and the importance of taking normative values in consideration when subjects with different socio-cultural or socio-economic backgrounds are assessed.

Abstract

The present study used event-related potentials to investigate whether the processing of grammatical gender agreement involving gender regular and irregular forms recruit the same or distinct neurocognitive mechanisms and whether different grammatical gender agreement conditions elicit the same or diverse ERP signals. Native speakers of Brazilian Portuguese read sentences containing congruent and incongruent grammatical gender agreement between a determiner and a regular or an irregular form (condition 1) and between a regular or an irregular form and an adjective (condition 2). However, in condition 2, trials with incongruent regular forms elicited more positive ongoing waveforms than trial with incongruent irregular forms. We found a biphasic LAN/P600 effect for gender agreement violation involving regular and irregular forms in both conditions. Our findings suggest that gender agreement between determiner and nouns recruits the same neurocognitive mechanisms regardless of the nouns’ form and that, depending on the grammatical class of the words involved in gender agreement, differences in ERP signals can emerge

Abstract

The status of thematic roles such as Agent and Patient in cognitive science is highly controversial: To some they are universal components of core knowledge, to others they are scholarly fictions without psychological reality. We address this debate by posing two critical questions: to what extent do humans represent events in terms of abstract role categories, and to what extent are these categories shaped by universal cognitive biases? We review a range of literature that contributes answers to these questions: psycholinguistic and event cognition experiments with adults, children, and infants; typological studies grounded in cross-linguistic data; and studies of emerging sign languages. We pose these questions for a variety of roles and find that the answers depend on the role. For Agents and Patients, there is strong evidence for abstract role categories and a universal bias to distinguish the two roles. For Goals and Recipients, we find clear evidence for abstraction but mixed evidence as to whether there is a bias to encode Goals and Recipients as part of one or two distinct categories. Finally, we discuss the Instrumental role and do not find clear evidence for either abstraction or universal biases to structure instrumental categories.

Abstract

Many psycholinguistic models of speech sequence planning make claims about the onset and offset times of planning units, such as words, syllables, and phonemes. These predictions typically go untested, however, since psycholinguists have assumed that the temporal dynamics of the speech signal is a poor index of the temporal dynamics of the underlying speech planning process. This article argues that this problem is tractable, and presents and validates two simple metrics that derive planning unit onset and offset times from the acoustic signal and articulatographic data.

Abstract

Four form-preparation experiments investigated whether aspects of phonological encoding processes and representations are shared between languages in bilingual speakers. The participants were Dutch--English bilinguals. Experiment 1 showed that the basic rightward incrementality revealed in studies for the first language is also observed for second-language words. In Experiments 2 and 3, speakers were given words to produce that did or did not share onset segments, and that came or did not come from different languages. It was found that when onsets were shared among the response words, those onsets were prepared, even when the words came from different languages. Experiment 4 showed that preparation requires prior knowledge of the segments and that knowledge about their phonological features yields no effect. These results suggest that both first- and second-language words are phonologically planned through the same serial order mechanism and that the representations of segments common to the languages are shared.

Abstract

This article presents a new account of the color-word Stroop phenomenon ( J. R. Stroop, 1935) based on an implemented model of word production, WEAVER++ ( W. J. M. Levelt, A. Roelofs, & A. S. Meyer, 1999b; A. Roelofs, 1992, 1997c). Stroop effects are claimed to arise from processing interactions within the language-production architecture and explicit goal-referenced control. WEAVER++ successfully simulates 16 classic data sets, mostly taken from the review by C. M. MacLeod (1991), including incongruency, congruency, reverse-Stroop, response-set, semantic-gradient, time-course, stimulus, spatial, multiple-task, manual, bilingual, training, age, and pathological effects. Three new experiments tested the account against alternative explanations. It is shown that WEAVER++ offers a more satisfactory account of the data than other models.

Abstract

Accounts that specify semantic and/or syntactic complexity as the primary determinant of the order in which children acquire particular words or grammatical constructions have been highly influential in the literature on question acquisition. One explanation of wh-question acquisition in particular suggests that the order in which English speaking children acquire wh-questions is determined by two interlocking linguistic factors; the syntactic function of the wh-word that heads the question and the semantic generality (or ‘lightness’) of the main verb (Bloom, Merkin & Wootten, 1982; Bloom, 1991). Another more recent view, however, is that acquisition is influenced by the relative frequency with which children hear particular wh-words and verbs in their input (e.g. Rowland & Pine, 2000). In the present study over 300 hours of naturalistic data from twelve two- to three-year-old children and their mothers were analysed in order to assess the relative contribution of complexity and input frequency to wh-question acquisition. The analyses revealed, first, that the acquisition order of wh-questions could be predicted successfully from the frequency with which particular wh-words and verbs occurred in the children's input and, second, that syntactic and semantic complexity did not reliably predict acquisition once input frequency was taken into account. These results suggest that the relationship between acquisition and complexity may be a by-product of the high correlation between complexity and the frequency with which mothers use particular wh-words and verbs. We interpret the results in terms of a constructivist view of language acquisition.

Abstract

Van Valin (Journal of Child Language29, 2002, 161–75) presents a critique of Rowland & Pine (Journal of Child Language27, 2000, 157–81) and argues that the wh-question data from Adam (in Brown, A first language, Cambridge, MA, 1973) cannot be explained in terms of input frequencies as we suggest. Instead, he suggests that the data can be more successfully accounted for in terms of Role and Reference Grammar. In this note we re-examine the pattern of inversion and uninversion in Adam's wh-questions and argue that the RRG explanation cannot account for some of the developmental facts it was designed to explain.

Abstract

This study investigated the extent to which 3- and 4-year-old children may rely on associative memory representations to pass an unexpected-contents false-belief task. In Experiment 1, 4-year-olds performed at chance in both a standard Smarties task and a modified version highlighting the secrecy of the contents of the tube. These results were interpreted as evidence that having to infer the answer to a false-belief question (without relying on memory representations) is generally difficult for preschool children. In Experiments 2a, 2b, and 2c, 3-year-olds were tested at 3-month intervals during their first year of preschool and showed better performance in a narrative version of the Smarties task (chance level) than in the standard version (below-chance level). These children performed even better in an associative version of the narrative task (above-chance level) where they could form a memory representation associating the protagonist with the expected contents of a box. The results of a true-belief control suggest that some of these children may have relied on their memory of the protagonist’s preference for the original contents of the box (rather than their understanding of what the protagonist was expecting to find inside). This suggests that when 3-year-olds passed the associative unexpected-contents task, some may have been keeping track of the protagonist’s initial preference and not only (or not necessarily) of the protagonist’s false belief. These results are interpreted in the light of current accounts of Theory of Mind development and failed replications of verbal false-belief tasks.

Abstract

The Violation-of-Expectation paradigm is a widespread paradigm in infancy research that relies on looking time as an index of surprise. This methodological review aims to increase the reliability of future VoE studies by proposing to standardize reporting practices in this literature. I review 15 VoE studies on false-belief reasoning, which used a variety of experimental parameters. An analysis of the distribution of p-values across experiments suggests an absence of p-hacking. However, there are potential concerns with the accuracy of their measures of infants’ attention, as well as with the lack of a consensus on the parameters that should be used to set up VoE studies. I propose that (i) future VoE studies ought to report not only looking times (as a measure of attention) but also looking-away times (as an equally important measure of distraction); (ii) VoE studies must offer theoretical justification for the parameters they use, and (iii) when parameters are selected through piloting, pilot data must be reported in order to understand how parameters were selected. Future VoE studies ought to maximize the accuracy of their measures of infants’ attention since the reliability of their results and the validity of their conclusions both depend on the accuracy of their measures.

Abstract

There is an ongoing debate, both in philosophy and psychology, as to whether people are able to automatically infer what others may know, or whether they can only derive belief inferences by deploying cognitive resources. Evidence from laboratory tasks, often involving false beliefs or visual-perspective taking, has suggested that belief inferences are cognitively costly, controlled processes. Here we suggest that in everyday conversation, belief reasoning is pervasive and therefore potentially automatic in some cases. To test this hypothesis, we conducted two pre-registered self-paced reading experiments (N1 = 91, N2 = 89). The results of these experiments showed that participants slowed down when a stranger commented ‘That greasy food is bad for your ulcer’ relative to conditions where a stranger commented on their own ulcer or a friend made either comment – none of which violated participants’ common-ground expectations. We conclude that Theory of Mind models need to account for belief reasoning in conversation as it is at the center of everyday social interaction

Abstract

A pragmatic account of referential communication is developed which presents an alternative to traditional Gricean accounts by focusing on cooperativeness and efficiency, rather than informativity. The results of four language-production experiments support the view that speakers can be cooperative when producing redundant adjectives, doing so more often when color modification could facilitate the listener's search for the referent in the visual display (Experiment 1a). By contrast, when the listener knew which shape was the target, speakers did not produce redundant color adjectives (Experiment 1b). English speakers used redundant color adjectives more often than Spanish speakers, suggesting that speakers are sensitive to the differential efficiency of prenominal and postnominal modification (Experiment 2). Speakers were also cooperative when using redundant size adjectives (Experiment 3). Overall, these results show how discriminability affects a speaker's choice of referential expression above and beyond considerations of informativity, supporting the view that redundant speakers can be cooperative.

Abstract

In this article, we present the spatial logistics task (SLOT) platform for investigating multimodal communication between 2 human participants. Presented are the SLOT communication task and the software and hardware that has been developed to run SLOT experiments and record the participants’ multimodal behavior. SLOT offers a high level of flexibility in varying the context of the communication and is particularly useful in studies of the relationship between pen gestures and speech. We illustrate the use of the SLOT platform by discussing the results of some early experiments. The first is an experiment on negotiation with a one-way mirror between the participants, and the second is an exploratory study of automatic recognition of spontaneous pen gestures. The results of these studies demonstrate the usefulness of the SLOT platform for conducting multimodal communication research in both human– human and human–computer interactions.

Abstract

We study how people attend to and memorize endings of events that differ in the degree to which objects in them are affected by an action: Resultative events show objects that undergo a visually salient change in state during the course of the event (peeling a potato), and non‐resultative events involve objects that undergo no, or only partial state change (stirring in a pan). We investigate general cognitive principles, and potential language‐specific influences, in verbal and nonverbal event encoding and memory, across two experiments with Dutch and Estonian participants. Estonian marks a viewer's perspective on an event's result obligatorily via grammatical case on direct object nouns: Objects undergoing a partial/full change in state in an event are marked with partitive/accusative case, respectively. Therefore, we hypothesized increased saliency of object states and event results in Estonian speakers, as compared to speakers of Dutch. Findings show (a) a general cognitive principle of attending carefully to endings of resultative events, implying cognitive saliency of object states in event processing; (b) a language‐specific boost on attention and memory of event results under verbal task demands in Estonian speakers. Results are discussed in relation to theories of event cognition, linguistic relativity, and thinking for speaking.

Abstract

Participants' eye movements were monitored as they heard sentences and saw four pictured objects on a computer screen. Participants were instructed to click on the object mentioned in the sentence. There were more transitory fixations to pictures representing monosyllabic words (e.g. ham) when the first syllable of the target word (e.g. hamster) had been replaced by a recording of the monosyllabic word than when it came from a different recording of the target word. This demonstrates that a phonemically identical sequence can contain cues that modulate its lexical interpretation. This effect was governed by the duration of the sequence, rather than by its origin (i.e. which type of word it came from). The longer the sequence, the more monosyllabic-word interpretations it generated. We argue that cues to lexical-embedding disambiguation, such as segmental lengthening, result from the realization of a prosodic boundary that often but not always follows monosyllabic words, and that lexical candidates whose word boundaries are aligned with prosodic boundaries are favored in the word-recognition process.

Abstract

Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.

Abstract

The epigenetic enzyme p300/CBP-associated factor (PCAF) belongs to the GCN5-related N-acetyltransferase (GNAT) family together with GCN5. Although its transcriptional and post-translational function is well characterized, little is known about its properties as regulator of cell metabolism. Here, we report the mitochondrial localization of PCAF conferred by an 85 aa mitochondrial targeting sequence (MTS) at the N-terminal region of the protein. In mitochondria, one of the PCAF targets is the isocitrate dehydrogenase 2 (IDH2) acetylated at lysine 180. This PCAF-regulated post-translational modification might reduce IDH2 affinity for isocitrate as a result of a conformational shift involving predictively the tyrosine at position 179. Site-directed mutagenesis and functional studies indicate that PCAF regulates IDH2, acting at dual level during myoblast differentiation: at a transcriptional level together with MyoD, and at a post-translational level by direct modification of lysine acetylation in mitochondria. The latter event determines a decrease in IDH2 function with negative consequences on muscle fiber formation in C2C12 cells. Indeed, a MTS-deprived PCAF does not localize into mitochondria, remains enriched into the nucleus, and contributes to a significant increase of muscle-specific gene expression enhancing muscle differentiation. The role of PCAF in mitochondria is a novel finding shedding light on metabolic processes relevant to early muscle precursor differentiation.—Savoia, M., Cencioni, C., Mori, M., Atlante, S., Zaccagnini, G., Devanna, P., Di Marcotullio, L., Botta, B., Martelli, F., Zeiher, A. M., Pontecorvi, A., Farsetti, A., Spallotta, F., Gaetano, C. P300/CBP-associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation.

Abstract

This letter evaluates potential benefits of combining human speech recognition ~HSR! and automatic speech recognition by building a joint model of an automatic phone recognizer ~APR! and a computational model of HSR, viz., Shortlist @Norris, Cognition 52, 189–234 ~1994!#. Experiments based on ‘‘real-life’’ speech highlight critical limitations posed by some of the simplifying assumptions made in models of human speech recognition. These limitations could be overcome by avoiding hard phone decisions at the output side of the APR, and by using a match between the input and the internal lexicon that flexibly copes with deviations from canonical phonemic representations.

Abstract

In this paper, we present an automatic speech recognition (ASR) system based on the combination of an automatic phone recogniser and a computational model of human speech recognition – SpeM – that is capable of computing ‘word activations’ during the recognition process, in addition to doing normal speech recognition, a task in which conventional ASR architectures only provide output after the end of an utterance. We explain the notion of word activation and show that it can be used for ‘early recognition’, i.e. recognising a word before the end of the word is available. Our ASR system was tested on 992 continuous speech utterances, each containing at least one target word: a city name of at least two syllables. The results show that early recognition was obtained for 72.8% of the target words that were recognised correctly. Also, it is shown that word activation can be used as an effective confidence measure.

Abstract

Exposure to traumatic stress increases the odds of developing a broad range of psychiatric conditions. Genetic studies targeting multiple stress-related quantitative phenotypes may shed light on mechanisms underlying vulnerability to psychopathology in the aftermath of stressful events. We applied a multivariate genome-wide association study (GWAS) to a unique military cohort (N = 583) in which we measured biochemical and behavioral phenotypes. The availability of pre- and post-deployment measurements allowed to capture changes in these phenotypes in response to stress. For genome-wide significant loci, we performed functional annotation, phenome-wide analysis and quasi-replication in PTSD case-control GWASs. We discovered one genetic variant reaching genome-wide significant association, surviving permutation and sensitivity analyses (rs10100651, p = 9.9 × 10−9). Functional annotation prioritized the genes INTS8 and TP53INP1. A phenome-wide scan revealed a significant association of these same genes with sleeping problems, hypertension and subjective well-being. Finally, a targeted lookup revealed nominally significant association of rs10100651 in a PTSD case-control GWAS in the UK Biobank (p = 0.02). We provide comprehensive evidence from multiple resources hinting at a role of the highlighted genetic variant in the human stress response, marking the power of multivariate genome-wide analysis of quantitative measures in stress research. Future genetic and functional studies can target this locus to further assess its effects on stress mediation and its possible role in psychopathology or resilience.

Abstract

During language production and comprehension, information about a word's syntactic properties is sometimes needed. While the decision about the grammatical gender of a word requires access to syntactic knowledge, it has also been hypothesized that semantic (i.e., biological gender) or phonological information (i.e., sound regularities) may influence this decision. Event-related potentials (ERPs) were measured while native speakers of German processed written words that were or were not semantically and/or phonologically marked for gender. Behavioral and ERP results showed that participants were faster in making a gender decision when words were semantically and/or phonologically gender marked than when this was not the case, although the phonological effects were less clear. In conclusion, our data provide evidence that even though participants performed a grammatical gender decision, this task can be influenced by semantic and phonological factors.

Abstract

This study investigated the time course of phonological encoding during speech production planning. Previous research has shown that conceptual/semantic information precedes syntactic information in the planning of speech production and that syntactic information is available earlier than phonological information. Here, we studied the relative time courses of the two different processes within phonological encoding, i.e. metrical encoding and syllabification. According to one prominent theory of language production, metrical encoding involves the retrieval of the stress pattern of a word, while syllabification is carried out to construct the syllabic structure of a word. However, the relative timing of these two processes is underspecified in the theory. We employed an implicit picture naming task and recorded event-related brain potentials to obtain fine-grained temporal information about metrical encoding and syllabification. Results revealed that both tasks generated effects that fall within the time window of phonological encoding. However, there was no timing difference between the two effects, suggesting that they occur approximately at the same time.

Abstract

In this study, we investigated grammatical feature selection during noun phrase production in German and Dutch. More specifically, we studied the conditions under which different grammatical genders select either the same or different determiners or suffixes. Pictures of one or two objects paired with a gender-congruent or a gender-incongruent distractor word were presented. Participants named the pictures using a singular or plural noun phrase with the appropriate determiner and/or adjective in German or Dutch. Significant effects of gender congruency were only obtained in the singular condition where the selection of determiners is governed by the target’s gender, but not in the plural condition where the determiner is identical for all genders. When different suffixes were to be selected in the gender-incongruent condition, no gender congruency effect was obtained. The results suggest that the so-called gender congruency effect is really a determiner congruency effect. The overall pattern of results is interpreted as indicating that grammatical feature selection is an automatic consequence of lexical node selection and therefore not subject to interference from other grammatical features. This implies that lexical node and grammatical feature selection operate with distinct principles.

Abstract

Speakers can use pronouns when their conceptual referents are accessible from the preceding discourse, as in 'The flower is red. It turns blue'. Theories of language production agree that in order to produce a noun semantic, syntactic, and phonological information must be accessed. However, little is known about lexical access to pronouns. In this paper, we propose a model of pronoun access in German. Since the forms of German pronouns depend on the grammatical gender of the nouns they replace, the model claims that speakers must access the syntactic representation of the replaced noun (its lemma) to select a pronoun. In two experiments using the lexical decision during naming paradigm [Levelt, W.J.M., Schriefers, H., Vorberg, D., Meyer, A.S., Pechmann, T., Havinga, J., 1991a. The time course of lexical access in speech production: a study of picture naming. Psychological Review 98, 122-142], we investigated whether lemma access automatically entails the activation of the corresponding word form or whether a word form is only activated when the noun itself is produced, but not when it is replaced by a pronoun. Experiment 1 showed that during pronoun production the phonological form of the replaced noun is activated. Experiment 2 demonstrated that this phonological activation was not a residual of the use of the noun in the preceding sentence. Thus, when a pronoun is produced, the lemma and the phonological form of the replaced noun become reactivated.

Abstract

This dataset, colloquially known as the Mother Of Unification Studies (MOUS) dataset, contains multimodal neuroimaging data that has been acquired from 204 healthy human subjects. The neuroimaging protocol consisted of magnetic resonance imaging (MRI) to derive information at high spatial resolution about brain anatomy and structural connections, and functional data during task, and at rest. In addition, magnetoencephalography (MEG) was used to obtain high temporal resolution electrophysiological measurements during task, and at rest. All subjects performed a language task, during which they processed linguistic utterances that either consisted of normal or scrambled sentences. Half of the subjects were reading the stimuli, the other half listened to the stimuli. The resting state measurements consisted of 5 minutes eyes-open for the MEG and 7 minutes eyes-closed for fMRI. The neuroimaging data, as well as the information about the experimental events are shared according to the Brain Imaging Data Structure (BIDS) format. This unprecedented neuroimaging language data collection allows for the investigation of various aspects of the neurobiological correlates of language.

Abstract

Speakers are influenced by the linguistic context: hearing one syntactic alternative leads to an increased chance that the speaker will repeat this structure in the subsequent utterance (i.e., syntactic priming, or structural persistence). Top-down influences, such as whether a conversation partner (or, interlocutor) is present, may modulate the degree to which syntactic priming occurs. In the current study, we indeed show that the magnitude of syntactic alignment increases when speakers are interacting with an interlocutor as opposed to doing the experiment alone. The structural persistence effect for passive sentences is stronger in the presence of an interlocutor than when no interlocutor is present (i.e., when the participant is primed by a recording). We did not find evidence, however, that a speaker’s syntactic priming magnitude is influenced by the degree of their conversation partner’s priming magnitude. Together, these results support a mediated account of syntactic priming, in which syntactic choices are not only affected by preceding linguistic input, but also by top-down influences, such as the speakers’ communicative intent.

Abstract

Speakers can adapt their speech and co-speech gestures based on knowledge shared with an addressee (common ground-based recipient design). Here, we investigate whether these adaptations are modulated by the speaker’s age and cognitive abilities. Younger and older participants narrated six short comic stories to a same-aged addressee. Half of each story was known to both participants, the other half only to the speaker. The two age groups did not differ in terms of the number of words and narrative events mentioned per narration, or in terms of gesture frequency, gesture rate, or percentage of events expressed multimodally. However, only the younger participants reduced the amount of verbal and gestural information when narrating mutually known as opposed to novel story content. Age-related differences in cognitive abilities did not predict these differences in common ground-based recipient design. The older participants’ communicative behaviour may therefore also reflect differences in social or pragmatic goals.

Abstract

Background

Voluntary shifts of visuospatial attention are associated with a lateralization of parieto-occipital alpha power (7-13Hz), i.e. higher power in the hemisphere ipsilateral and lower power contralateral to the locus of attention. Recent noninvasive neuromodulation studies demonstrated that alpha power can be experimentally increased using transcranial alternating current stimulation (tACS).
Objective/Hypothesis

We hypothesized that tACS at alpha frequency over the left parietal cortex induces shifts of attention to the left hemifield. However, spatial attention shifts not only occur voluntarily (endogenous/ top-down), but also stimulus-driven (exogenous/ bottom-up). To study the task-specificity of the potential effects of tACS on attentional processes, we administered three conceptually different spatial attention tasks.
Methods

36 healthy volunteers were recruited from an academic environment. In two separate sessions, we applied either high-density tACS at 10Hz, or sham tACS, for 35–40 minutes to their left parietal cortex. We systematically compared performance on endogenous attention, exogenous attention, and stimulus detection tasks.
Results

In the endogenous attention task, a greater leftward bias in reaction times was induced during left parietal 10Hz tACS as compared to sham. There were no stimulation effects in either the exogenous attention or the stimulus detection task.
Conclusion

The study demonstrates that high-density tACS at 10Hz can be used to modulate visuospatial attention performance. The tACS effect is task-specific, indicating that not all forms of attention are equally susceptible to the stimulation.

Abstract

Exposure to trauma strongly increases the risk to develop stress-related psychopathology, such as post-traumatic stress disorder (PTSD) or major depressive disorder (MDD). In addition, liability to develop these moderately heritable disorders is partly determined by common genetic variance, which is starting to be uncovered by genome-wide association studies (GWASs). However, it is currently unknown to what extent genetic vulnerability and trauma interact. We investigated whether genetic risk based on summary statistics of large GWASs for PTSD and MDD predisposed individuals to report an increase in MDD and PTSD symptoms in a prospective military cohort (N = 516) at five time points after deployment to Afghanistan: one month, six months and one, two and five years. Linear regression was used to analyze the contribution of polygenic risk scores (PRSs, at multiple p-value thresholds) and their interaction with deployment-related trauma to the development of PTSD- and depression-related symptoms. We found no main effects of PRSs nor evidence for interactions with trauma on the development of PTSD or depressive symptoms at any of the time points in the five years after military deployment. Our results based on a unique long-term follow-up of a deployed military cohort suggest limited validity of current PTSD and MDD polygenic risk scores, albeit in the presence of minimal severe psychopathology in the target cohort. Even though the predictive value of PRSs will likely benefit from larger sample sizes in discovery and target datasets, progress will probably also depend on (endo)phenotype refinement that in turn will reduce etiological heterogeneity.

Abstract

Encoding the temporal properties of external signals that comprise multimodal events is a major factor guiding everyday experience. However, during the natural aging process, impairments to sensory processing can profoundly affect multimodal temporal perception. Various mechanisms can contribute to temporal perception, and thus it is imperative to understand how each can be affected by age. In the current study, using three different temporal order judgement tasks (unisensory, multisensory, and sensorimotor), we investigated the effects of age on two separate temporal processes: synchronization and integration of multiple signals. These two processes rely on different aspects of temporal information, either the temporal alignment of processed signals or the integration/segregation of signals arising from different modalities, respectively. Results showed that the ability to integrate/segregate multiple signals decreased with age regardless of the task, and that the magnitude of such impairment correlated across tasks, suggesting a widespread mechanism affected by age. In contrast, perceptual synchrony remained stable with age, revealing a distinct intact mechanism. Overall, results from this study suggest that aging has differential effects on temporal processing, and general impairments with aging may impact global temporal sensitivity while context-dependent processes remain unaffected.

Abstract

Visiting the Trobriand Islands is advertised as being the highlight of a trip for tourists to Papua New Guinea who want, and can afford, to experience this 'ultimate adventure' with 'expeditionary cruises aboard the luxurious Melanesian Discoverer. The advertisements also promise that the tourists can 'meet the friendly people' and 'observe their unique culture, dances, and art'. During my research in Kaibola and Nuwebila, two neighbouring villages on the northern tip of Kiriwina Island, I studied and analysed the encounters of tourists with Trobriand Islanders, who sing and dance for the Europeans. The analyses of the islanders' tourist performances are based on Erving Goffman's now classic study The Presentation of Self in Everyday Life, which was first published in 1959. In this study Goffmann analyses the structures of social encounters from the perspective of the dramatic performance. The situational context within which the encounter between tourists and Trobriand Islanders takes place frames the tourists as the audience and the Trobriand Islanders as a team of performers. The inherent structure of the parts of the overall performance presented in the two villages can be summarized - within the framework of Goffman's approach - in analogy with the structure of drama. We find parts that constitute the 'exposition', the 'complication', and the 'resolution' of a drama; we even observe an equivalent to the importance of the 'Second Act Curtain' in modern drama theory. Deeper analyses of this encounter show that the motives of the performers and their 'art of impression management' are to control the impression their audience receives in this encounter situation. This analysis reveals that the Trobriand Islanders sell their customers the expected images of what Malinowski (1929) once termed the '...Life of Savages in North-Western Melanesia' in a staged 'illusion'. With the conscious realization of the part they as performers play in this encounter, the Trobriand Islanders are in a position that is superior to that of their audience. Their merchandise or commodity is 'not real', as it is sold 'out of its true cultural context'. It is staged - and thus cannot be taken by any customer whatsoever because it (re)presents just an 'illusion'. The Trobriand Islanders know that neither they nor the core aspects of their culture will suffer any damage within a tourist encounter that is defined by the structure and the kind of their performance. Their pride and self-confidence enable them to bring their superior position into play in their dealings with tourists. With their indigenous humour, they even use this encounter for ridiculing their visitors. It turns out that the encounter is another manifestation of the Trobriand Islanders' self-consciousness, self-confidence, and pride with which they manage to protect core aspects of their cultural identity, while at the same time using and 'selling' parts of their culture as a kind of commodity to tourists.

Abstract

The Open Access Movement promotes free and unfettered access to research publications and, increasingly, to the primary data which underly those publications. As the field of documentary linguistics seeks to record and preserve culturally and linguistically relevant materials, the question of how openly accessible these materials should be becomes increasingly important. This paper aims to guide researchers and other stakeholders in finding an appropriate balance between accessibility and confidentiality of data, addressing community questions and legal, institutional, and intellectual issues that pose challenges to accessible data.

Abstract

Autism spectrum disorder is increasingly associated with atypical perceptual and sensory symptoms. Here we explore the hypothesis
that aberrant sensory processing in autism spectrum disorder could be linked to atypical intra- (local) and interregional (global)
brain connectivity. To elucidate oscillatory dynamics and connectivity in the visual domain we used magnetoencephalography and
a simple visual grating paradigm with a group of 18 adolescent autistic participants and 18 typically developing control subjects.
Both groups showed similar increases in gamma (40–80 Hz) and decreases in alpha (8–13 Hz) frequency power in occipital cortex.
However, systematic group differences emerged when analysing intra- and interregional connectivity in detail. First, directed
connectivity was estimated using non-parametric Granger causality between visual areas V1 and V4. Feedforward V1-to-V4
connectivity, mediated by gamma oscillations, was equivalent between autism spectrum disorder and control groups, but importantly,
feedback V4-to-V1 connectivity, mediated by alpha (8–13 Hz) oscillations, was significantly reduced in the autism spectrum
disorder group. This reduction was positively correlated with autistic quotient scores, consistent with an atypical visual hierarchy
in autism, characterized by reduced top-down modulation of visual input via alpha-band oscillations. Second, at the local level in
V1, coupling of alpha-phase to gamma amplitude (alpha-gamma phase amplitude coupling) was reduced in the autism spectrum
disorder group. This implies dysregulated local visual processing, with gamma oscillations decoupled from patterns of wider alphaband
phase synchrony (i.e. reduced phase amplitude coupling), possibly due to an excitation-inhibition imbalance. More generally,
these results are in agreement with predictive coding accounts of neurotypical perception and indicate that visual processes in
autism are less modulated by contextual feedback information.

Abstract

Background Cognitive dysfunction is one of the most prominent characteristics of psychiatric disorders. At present, the neural correlates of cognitive dysfunction across psychiatric disorders are poorly understood. The aim of this study was to investigate functional connectivity and structural perturbations across psychiatric diagnoses in three neurocognitive networks of interest, including the default-mode (DMN), the frontoparietal (FPN) and the salience network (SN). Methods We performed meta-analyses of resting-state functional MRI (R-fMRI) whole-brain seed-based functional connectivity in 8,298 patients (involving 8 disorders) and 8,165 healthy controls and a voxel-based morphometry analysis of structural MRI data in 14,027 patients (involving 8 disorders) and healthy 14,504 controls. To aid the interpretation of the results, we examined neurocognitive function in 776 healthy participants from the Human Connectome Project. Results We found that the three neurocognitive networks of interest were characterized by shared alterations of functional connectivity architecture across psychiatric disorders. More specifically, hypoconnectivity was expressed between the DMN and ventral SN and between the SN and FPN, whereas hyperconnectivity was evident between the DMN and FPN and between the DMN and dorsal SN. This pattern of network alterations was associated with gray matter reductions in patients, and was localized in regions that subserve general cognitive performance. Conclusions This study is the first to provide meta-analytic evidence of common alterations of functional connectivity within and between neurocognitive networks. The findings suggest a shared mechanism of network interactions that may associate with the generalized cognitive deficits observed in psychiatric disorders.

Abstract

There is mounting evidence that the ease of producing and understanding language depends not only on the frequencies of individual words but also on the frequencies of word combinations. However, in two picture description experiments, Janssen and Barber (2012) found that French and Spanish speakers' speech onset latencies for short phrases depended exclusively on the frequencies of the phrases but not on the frequencies of the individual words. They suggested that speakers retrieved phrase-sized units from the mental lexicon. In the present study, we examined whether the time required to plan complex noun phrases in Dutch would likewise depend only on phrase frequencies. Participants described line drawings in phrases such as rode schoen [red shoe] (Experiments 1 and 2) or de rode schoen [the red shoe] (Experiment 3). Replicating Janssen and Barber's findings, utterance onset latencies depended on the frequencies of the phrases but, deviating from their findings, also depended on the frequencies of the adjectives in adjective-noun phrases and the frequencies of the nouns in determiner-adjective-noun phrases. We conclude that individual word frequencies and phrase frequencies both affect the time needed to produce noun phrases and discuss how these findings may be captured in models of the mental lexicon and of phrase production

Abstract

Interactions between top-down and bottom-up information streams are integral to brain function but challenging to measure noninvasively. Laminar resolution, functional MRI (lfMRI) is sensitive to depth-dependent properties of the blood oxygen level-dependent (BOLD) response, which can be potentially related to top-down and bottom-up signal contributions. In this work, we used lfMRI to dissociate the top-down and bottom-up signal contributions to the left occipitotemporal sulcus (LOTS) during word reading. We further demonstrate that laminar resolution measurements could be used to identify condition-specific distributed networks on the basis of whole-brain connectivity patterns specific to the depth-dependent BOLD signal. The networks corresponded to top-down and bottom-up signal pathways targeting the LOTS during word reading. We show that reading increased the top-down BOLD signal observed in the deep layers of the LOTS and that this signal uniquely related to the BOLD response in other language-critical regions. These results demonstrate that lfMRI can reveal important patterns of activation that are obscured at standard resolution. In addition to differences in activation strength as a function of depth, we also show meaningful differences in the interaction between signals originating from different depths both within a region and with the rest of the brain. We thus show that lfMRI allows the noninvasive measurement of directed interaction between brain regions and is capable of resolving different connectivity patterns at submillimeter resolution, something previously considered to be exclusively in the domain of invasive recordings.

Abstract

The acoustic dimensions that distinguish speech sounds (like the vowel differences in “boot” and “boat”) also differentiate speakers’ voices. Therefore, listeners must normalize across speakers without losing linguistic information. Past behavioral work suggests an important role for auditory contrast enhancement in normalization: preceding context affects listeners’ perception of subsequent speech sounds. Here, using intracranial electrocorticography in humans, we investigate whether and how such context effects arise in auditory cortex. Participants identified speech sounds that were preceded by phrases from two different speakers whose voices differed along the same acoustic dimension as target words (the lowest resonance of the vocal tract). In every participant, target vowels evoke a speaker-dependent neural response that is consistent with the listener’s perception, and which follows from a contrast enhancement model. Auditory cortex processing thus displays a critical feature of normalization, allowing listeners to extract meaningful content from the voices of diverse speakers.

Abstract

It is widely accepted that specific memory processes, such as serial-order memory, are involved in written language development and predictive of reading and spelling abilities. The reverse question, namely whether orthographic abilities also affect serial-order memory, has hardly been investigated. In the current study, we compared 20 illiterate people with a group of 20 literate matched controls on a verbal and a visuospatial version of the Hebb paradigm, measuring both short- and long-term serial-order memory abilities. We observed better short-term serial-recall performance for the literate compared with the illiterate people. This effect was stronger in the verbal than in the visuospatial modality, suggesting that the improved capacity of the literate group is a consequence of learning orthographic skills. The long-term consolidation of ordered information was comparable across groups, for both stimulus modalities. The implications of these findings for current views regarding the bi-directional interactions between memory and written language development are discussed.

Abstract

We present the results of a large-scale study on speech perception, assessing the number and type of perceptual hypotheses which listeners entertain about possible phoneme sequences in their language. Dutch listeners were asked to identify gated fragments of all 1179 diphones of Dutch, providing a total of 488 520 phoneme categorizations. The results manifest orderly uptake of acoustic information in the signal. Differences across phonemes in the rate at which fully correct recognition was achieved arose as a result of whether or not potential confusions could occur with other phonemes of the language ~long with short vowels, affricates with their initial components, etc.!. These data can be used to improve models of how acoustic phonetic information is mapped onto the mental lexicon during speech comprehension.

Abstract

Blindsight refers to the observation of residual visual abilities in the hemianopic field of patients without a functional V1. Given the within- and between-subject variability in the preserved abilities and the phenomenal experience of blindsight patients, the fine-grained description of the phenomenon is still debated. Here we tested a patient with established “perceptual” and “attentional” blindsight (c.f. Danckert and Rossetti, 2005). Using a pointing paradigm patient MS, who suffers from a complete left homonymous hemianopia, showed clear above chance manual localisation of ‘unseen’ targets. In addition, target presentations in his blind field led MS, on occasion, to spontaneous responses towards his sighted field. Structural and functional magnetic resonance imaging was conducted to evaluate the magnitude of V1 damage. Results revealed the presence of a calcarine sulcus in both hemispheres, yet his right V1 is reduced, structurally disconnected and shows no fMRI response to visual stimuli. Thus, visual stimulation of his blind field can lead to “action blindsight” and spontaneous antipointing, in absence of a functional right V1. With respect to the antipointing, we suggest that MS may have registered the stimulation and subsequently presumes it must have been in his intact half field.

Abstract

POU3F3, also referred to as Brain-1, is a well-known transcription factor involved in the development of the central nervous system, but it has not previously been associated with a neurodevelopmental disorder. Here, we report the identification of 19 individuals with heterozygous POU3F3 disruptions, most of which are de novo variants. All individuals had developmental delays and/or intellectual disability and impairments in speech and language skills. Thirteen individuals had characteristic low-set, prominent, and/or cupped ears. Brain abnormalities were observed in seven of eleven MRI reports. POU3F3 is an intronless gene, insensitive to nonsense-mediated decay, and 13 individuals carried protein-truncating variants. All truncating variants that we tested in cellular models led to aberrant subcellular localization of the encoded protein. Luciferase assays demonstrated negative effects of these alleles on transcriptional activation of a reporter with a FOXP2-derived binding motif. In addition to the loss-of-function variants, five individuals had missense variants that clustered at specific positions within the functional domains, and one small in-frame deletion was identified. Two missense variants showed reduced transactivation capacity in our assays, whereas one variant displayed gain-of-function effects, suggesting a distinct pathophysiological mechanism. In bioluminescence resonance energy transfer (BRET) interaction assays, all the truncated POU3F3 versions that we tested had significantly impaired dimerization capacities, whereas all missense variants showed unaffected dimerization with wild-type POU3F3. Taken together, our identification and functional cell-based analyses of pathogenic variants in POU3F3, coupled with a clinical characterization, implicate disruptions of this gene in a characteristic neurodevelopmental disorder.

Abstract

The anterior cingulate cortex (ACC) and the dorsolateral prefrontal cortex (DLPFC) are involved in conflict detection and
conflict resolution, respectively. Here, we investigate how lifelong bilingualism induces neuroplasticity to these structures by
employing a novel analysis of behavioural performance. We correlated grey matter volume (GMV) in seniors reported by
Abutalebi et al. (2015) with behavioral Flanker task performance fitted using the diffusion model (Ratcliff, 1978). As
predicted, we observed significant correlations between GMV in the DLPFC and Flanker performance. However, for
monolinguals the non-decision time parameter was significantly correlated with GMV in the left DLPFC, whereas for
bilinguals the correlation was significant in the right DLPFC. We also found a significant correlation between age and GMV
in left DLPFC and the non-decision time parameter for the conflict effect for monolinguals only.
We submit that this is due to cumulative demands on cognitive control over a lifetime of bilingual language processing

Abstract

In language comprehension, a variety of contextual cues act in unison to render upcoming words more or less predictable. As a sentence unfolds, we use prior context (sentential constraints) to predict what the next words might be. Additionally, in a conversation, we can predict upcoming sounds through observing the mouth movements of a speaker (visual constraints). In electrophysiological studies, effects of visual constraints have typically been observed early in language processing, while effects of sentential constraints have typically been observed later. We hypothesized that the visual and the sentential constraints might feed into the same predictive process such that effects of sentential constraints might also be detectable early in language processing through modulations of the early effects of visual salience. We presented participants with audiovisual speech while recording their brain activity with magnetoencephalography. Participants saw videos of a person saying sentences where the last word was either sententially constrained or not, and began with a salient or non-salient mouth movement. We found that sentential constraints indeed exerted an early (N1) influence on language processing. Sentential modulations of the N1 visual predictability effect were visible in brain areas associated with semantic processing, and were differently expressed in the two hemispheres. In the left hemisphere, visual and sentential constraints jointly suppressed the auditory evoked field, while the right hemisphere was sensitive to visual constraints only in the absence of strong sentential constraints. These results suggest that sentential and visual constraints can jointly influence even very early stages of audiovisual speech comprehension.

Abstract

We present results from cross-modal priming experiments on German participles and noun plurals. The experiments produced parallel results for both inflectional systems. Regular inflection exhibits full priming whereas irregularly inflected word forms show only partial priming: after hearing regularly inflected words (-t participles and -s plurals), lexical decision times on morphologically related word forms (presented visually) were similar to reaction times for a base-line condition in which prime and target were identical, but significantly shorter than in a control condition where prime and target were unrelated. In contrast, prior presentation of irregular words (-n participles and -er plurals) led to significantly longer response times on morphologically related word forms than the prior presentation of the target itself. Hence, there are clear priming differences between regularly and irregularly inflected German words. We compare the findings on German with experimental results on regular and irregular inflection in English and Italian, and discuss theoretical implications for single versus dual-mechanism models of inflection.

Abstract

Odors are often difficult to identify and name, which leaves them vulnerable to the influence of language. The present study tests the boundaries of the effect of language on odor cognition by examining the effect of grammatical gender. We presented participants with male and female fragrances paired with descriptions of masculine or feminine grammatical gender. In Experiment 1 we found that memory for fragrances was enhanced when the grammatical gender of a fragrance description matched the gender of the fragrance. In Experiment 2 we found memory for fragrances was affected by both grammatical gender and gender associations in fragrance descriptions – recognition memory for odors was higher when the gender was incongruent. In sum, we demonstrated that even subtle aspects of language can affect odor cognition.

Abstract

Bilingual children are often exposed to non-native speech through their parents. Yet, little is known about the relation between bilingual preschoolers’ speech production and their speech input. The present study investigated the production of voice onset time (VOT) by Dutch-German bilingual preschoolers and their sequential bilingual mothers. The findings reveal an association between maternal VOT and bilingual children’s VOT in the heritage language German as well as in the majority language Dutch. By contrast, no input-production association was observed in the VOT production of monolingual German-speaking children and monolingual Dutch-speaking children. The results of this study provide the first empirical evidence that non-native and attrited maternal speech contributes to the often-observed linguistic differences between bilingual children and their monolingual peers.

Abstract

Spoken language comprehension requires rapid integration of information from multiple linguistic sources. In the present study we addressed the temporal aspects of this integration process by focusing on the time course of the selection of the appropriate meaning of lexical ambiguities (“bank”) in sentence contexts. Successful selection of the contextually appropriate meaning of the ambiguous word is dependent upon the rapid binding of the contextual information in the sentence to the appropriate meaning of the ambiguity. We used the N400 to identify the time course of this binding process. The N400 was measured to target words that followed three types of context sentences. In the concordant context, the sentence biased the meaning of the sentence-final ambiguous word so that it was related to the target. In the discordant context, the sentence context biased the meaning so that it was not related to the target. In the unrelated control condition, the sentences ended in an unambiguous noun that was unrelated to the target. Half of the concordant sentences biased the dominant meaning, and the other half biased the subordinate meaning of the sentence-final ambiguous words. The ISI between onset of the target word and offset of the sentence-final word of the context sentence was 100 ms in one version of the experiment, and 1250 ms in the second version. We found that (i) the lexically dominant meaning is always partly activated, independent of context, (ii) initially both dominant and subordinate meaning are (partly) activated, which suggests that contextual and lexical factors both contribute to sentence interpretation without context completely overriding lexical information, and (iii) strong lexical influences remain present for a relatively long period of time.

Abstract

There exists a clear association between animacy and the grammatical function of transitive subject. The grammar of some languages require the transitive subject to be high in animacy, or at least higher than the object. A similar animacy preference has been observed in processing studies in languages without such a categorical animacy effect. This animacy preference has been mainly established in structures in which either one or both arguments are provided before the verb. Our goal was to establish (i) whether this preference can already be observed before any argument is provided, and (ii) whether this preference is mediated by verbal information. To this end we exploited the V2 property of Dutch which allows the verb to precede its arguments. Using a visual-world eye-tracking paradigm we presented participants with V2 structures with either an auxiliary (e.g. Gisteren heeft X … ‘Yesterday, X has …’) or a lexical main verb (e.g. Gisteren motiveerde X … ‘Yesterday, X motivated …’) and we measured looks to the animate referent. The results indicate that the animacy preference can already be observed before arguments are presented and that the selectional restrictions of the verb mediate this bias, but do not override it completely.

Abstract

Although infants show remarkable sensitivity to linguistically relevant phonetic variation in speech, young children sometimes appear not to make use of this sensitivity. Here, children's knowledge of the sound-forms of familiar words was assessed using a visual fixation task. Dutch 19-month-olds were shown pairs of pictures and heard correct pronunciations and mispronunciations of familiar words naming one of the pictures. Mispronunciations were word-initial in Experiment 1 and word-medial in Experiment 2, and in both experiments involved substituting one segment with [d] (a common sound in Dutch) or [g] (a rare sound). In both experiments, word recognition performance was better for correct pronunciations than for mispronunciations involving either substituted consonant. These effects did not depend upon children's knowledge of lexical or nonlexical phonological neighbors of the tested words. The results indicate the encoding of phonetic detail in words at 19 months.

Abstract

Two experiments examined the nature of access, storage, and comprehension of idiomatic phrases. In both studies a Phrase Classification Task was utilized. In this, reaction times to determine whether or not word strings constituted acceptable English phrases were measured. Classification times were significantly faster to idiom than to matched control phrases. This effect held under conditions involving different categories of idioms, different transitional probabilities among words in the phrases, and different levels of awareness of the presence of idioms in the materials. The data support a Lexical Representation Hypothesis for the processing of idioms.

Abstract

Memory representations of words are thought to undergo changes with consolidation: Episodic memories of novel words are transformed into lexical representations that interact with other words in the mental dictionary. Behavioral studies have shown that this lexical integration process is enhanced when there is more time for consolidation. Neuroimaging studies have further revealed that novel word representations are initially represented in a hippocampally-centered system, whereas left posterior middle temporal cortex activation increases with lexicalization. In this study, we measured behavioral and brain responses to newly-learned words in children. Two groups of Dutch children, aged between 8-10 and 14-16 years, were trained on 30 novel Japanese words depicting novel concepts. Children were tested on word-forms, word-meanings, and the novel words’ influence on existing word processing immediately after training, and again after a week. In line with the adult findings, hippocampal involvement decreased with time. Lexical integration, however, was not observed immediately or after a week, neither behaviorally nor neurally. It appears that time alone is not always sufficient for lexical integration to occur. We suggest that other factors (e.g., the novelty of the concepts and familiarity with the language the words are derived from) might also influence the integration process.

Abstract

The aim of the present study was to examine whether repetition of radicals during training of Chinese characters leads to better word acquisition performance in beginning learners of Chinese as a foreign language. Thirty Dutch university students were trained on 36 Chinese one-character words for their pronunciations and meanings. They were also exposed to the specifics of the radicals, that is, for phonetic radicals, the associated pronunciation was explained, and for semantic radicals the associated categorical meanings were explained. Results showed that repeated exposure to phonetic and semantic radicals through character pronunciation and meaning trainings indeed induced better understanding of those radicals that were shared among different characters. Furthermore, characters in the training set that shared phonetic radicals were pronounced better than those that did not. Repetition of semantic radicals across different characters, however, hindered the learning of exact meanings. Students generally confused the meanings of other characters that shared the semantic radical. The study shows that in the initial stage of learning, overlapping information of the shared radicals are effectively learned. Acquisition of the specifics of individual characters, however, requires more training.

Abstract

The murine homologue of the human chloride channel gene, CLCN5, defects in which are responsible for Dent disease, has been cloned and characterized. We isolated the entire coding region of mouse Clcn5 cDNA and approximately 45 kb of genomic sequence embracing the gene. To study its transcriptional control, the 5' upstream sequences of the mouse Clcn5 gene were cloned into a luciferase reporter vector. Deletion analysis of 1.5 kb of the 5' flanking sequence defined an active promoter region within 128 bp of the putative transcription start site, which is associated with a TATA motif but lacks a CAAT consensus. Within this sequence, there is a motif with homology to a purine-rich sequence responsible for the kidney-specific promoter activity of the rat CLC-K1 gene, another member of the chloride-channel gene family expressed in kidney. An enhancer element that confers a 10- to 20-fold increase in the promoter activity of the mouse Clcn5 gene was found within the first intron. The organization of the human CLCN5 and mouse Clcn5 gene structures is highly conserved, and the sequence of the murine protein is 98% similar to that of human, with its highest expression seen in the kidney. This study thus provides the first identification of the transcriptional control region of, and the basis for an understanding of the regulatory mechanism that controls, this kidney-specific, chloride-channel gene.

Abstract

The brain is inherently proactive, constantly predicting the when (moment) and what (content) of future input in order to optimize information processing. Previous research on such predictions has mainly studied the “when” or “what” domain separately, missing to investigate the potential integration of both types of predictive information. In the absence of such integration, temporal cues are assumed to enhance any upcoming content at the predicted moment in time (general temporal predictor). However, if the when and what prediction domain were integrated, a much more flexible neural mechanism may be proposed in which temporal-feature interactions would allow for the creation of multiple concurrent time-content predictions (parallel time-content predictor). Here, we used a temporal association paradigm in two experiments in which sound identity was systematically paired with a specific time delay after the offset of a rhythmic visual input stream. In Experiment 1, we revealed that participants associated the time delay of presentation with the identity of the sound. In Experiment 2, we unexpectedly found that the strength of this temporal association was negatively related to the EEG steady-state evoked responses (SSVEP) in preceding trials, showing that after high neuronal responses participants responded inconsistent with the time-content associations, similar to adaptation mechanisms. In this experiment, time-content associations were only present for low SSVEP responses in previous trials. These results tentatively show that it is possible to represent multiple time-content paired predictions in parallel, however, future research is needed to investigate this interaction further.

Abstract

This paper presents electrophysiological data on the on-line processing of open- and closed-class words in patients with Broca’s aphasia with agrammatic comprehension. Event-related brain potentials were recorded from the scalp when Broca patients and nonaphasic control subjects were visually presented with a story in which the words appeared one at a time on the screen. Separate waveforms were computed for open- and closed-class words. The non-aphasic control subjects showed clear differences between the processing of open- and closed-class words in an early (210-375 ms) and a late (400-700 ms) time-window.The early electrophysiological differences reflect the first manifestation of the availability of word-category information from the mental lexicon. The late differences presumably relate to post-lexical semantic and syntactic processing. In contrast to the control subjects, the Broca patients showed no early vocabulary class effect and only a limited late effect. The results suggest that an important factor in the agrammatic comprehension deficit of Broca’s aphasics is a delayed and/or incomplete availability of word-class information.

Abstract

This paper discusses the development of an orthography for the Touo language (Solomon Islands). Various orthographies have been proposed for this language in the past, and the paper discusses why they are perceived by the community to have failed. Current opinion about orthography development within the Touo-speaking community is divided along religious, political, and geographical grounds; and the development of a successful orthography must take into account a variety of opinions. The paper examines the social, historical, and linguistic obstacles that have hitherto prevented the development of an accepted Touo orthography, and presents a new proposal which has thus far gained acceptance with community leaders. The fundamental issue is that creating an orthography for a language takes place in a social, political, and historical context; and for an orthography to be acceptable for the speakers of a language, all these factors must be taken into account.

Abstract

The extent to which linguistic borrowing can be used to shed light on the existence and nature of early contact between Papuan and Oceanic speakers is examined. The question is addressed by taking one Papuan language, Lavukaleve, spoken in the Russell Islands, central Solomon Islands and examining lexical borrowings between it and nearby Oceanic languages, and with reconstructed forms of Proto Oceanic. Evidence from ethnography, culture history and archaeology, when added to the linguistic evidence provided in this study, indicates long-standing cultural links between other (non-Russell) islands. The composite picture is one of a high degree of cultural contact with little linguistic mixing, i.e., little or no changes affecting the structure of the languages and actually very little borrowed vocabulary.

Abstract

Our understanding of the functioning of the brain is primarily based on an average model of the brain's functional organisation, and any deviation from the standard is considered as random noise or a pathological appearance. Studying pathologies has, however, greatly contributed to our understanding of brain functions. For instance, the study of naturally-occurring or surgically-induced brain lesions revealed that language is predominantly lateralised to the left hemisphere while perception/action and emotion are commonly lateralised to the right hemisphere. The lateralisation of function was subsequently replicated by task-related functional neuroimaging in the healthy population. Despite its high significance and reproducibility, this pattern of lateralisation of function is true for most, but not all participants. Bilateral and flipped representations of classically lateralised functions have been reported during development and in the healthy adult population for language, perception/action and emotion. Understanding these different functional representations at an individual level is crucial to improve the sophistication of our models and account for the variance in developmental trajectories, cognitive performance differences and clinical recovery. With the availability of in vivo neuroimaging, it has become feasible to study large numbers of participants and reliably characterise individual differences, also referred to as phenotypes. Yet, we are at the beginning of inter-individual variability modelling, and new theories of brain function will have to account for these differences across participants.

Abstract

Synaesthesia is a neurological phenomenon affecting perception, where triggering stimuli (e.g. letters and numbers) elicit unusual secondary sensory experiences (e.g. colours). Family-based studies point to a role for genetic factors in the development of this trait. However, the contributions of common genomic variation to synaesthesia have not yet been investigated. Here, we present the SynGenes cohort, the largest genotyped collection of unrelated people with grapheme–colour synaesthesia (n = 723). Synaesthesia has been associated with a range of other neuropsychological traits, including enhanced memory and mental imagery, as well as greater sensory sensitivity. Motivated by the prior literature on putative trait overlaps, we investigated polygenic scores derived from published genome-wide scans of schizophrenia and autism spectrum disorder (ASD), comparing our SynGenes cohort to 2181 non-synaesthetic controls. We found a very slight association between schizophrenia polygenic scores and synaesthesia (Nagelkerke's R2 = 0.0047, empirical p = 0.0027) and no significant association for scores related to ASD (Nagelkerke's R2 = 0.00092, empirical p = 0.54) or body mass index (R2 = 0.00058, empirical p = 0.60), included as a negative control. As sample sizes for studying common genomic variation continue to increase, genetic investigations of the kind reported here may yield novel insights into the shared biology between synaesthesia and other traits, to complement findings from neuropsychology and brain imaging.

Abstract

Contrary to the Gricean maxims of quantity (Grice, in: Cole, Morgan (eds) Syntax and semantics: speech acts, vol III, pp 41–58, Academic Press, New York, 1975), it has been repeatedly shown that speakers often include redundant information in their utterances (over-specifications). Previous research on referential communication has long debated whether this redundancy is the result of speaker-internal or addressee-oriented processes, while it is also unclear whether referential redundancy hinders or facilitates comprehension. We present an information-theoretic explanation for the use of over-specification in visually-situated communication, which quantifies the amount of uncertainty regarding the referent as entropy (Shannon in Bell Syst Tech J 5:10, https://doi.org/10.1002/j.1538-7305.1948.tb01338.x, 1948). Examining both the comprehension and production of over-specifications, we present evidence that (a) listeners’ processing is facilitated by the use of redundancy as well as by a greater reduction of uncertainty early on in the utterance, and (b) that at least for some speakers, listeners’ processing concerns influence their encoding of over-specifications: Speakers were more likely to use redundant adjectives when these adjectives reduced entropy to a higher degree than adjectives necessary for target identification.