Amaia Carrión Castillo


Displaying 1 - 11 of 11
  • Carrion Castillo, A., Pepe, A., Kong, X., Fisher, S. E., Mazoyer, B., Tzourio-Mazoyer, N., Crivello, F., & Francks, C. (2019). Genetics of planum temporale asymmetry: limited relevance to disorders and cognitive variability. Poster presented at the 25th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2019), Rome, Italy.
  • Carrion Castillo, A., Tzourio-Mazoyer, N., Kavaklioglu, T., Badillo, S., Chavent, M., Saracco, J., Fisher, S. E., Mazoyer, B., & Francks, C. (2018). Genome sequencing for rightward hemispheric language dominance. Poster presented at the 11th FENS Forum of Neuroscience (FENS 2018), Berlin, Germany.
  • Carrion Castillo, A., Tzourio-Mazoyer, N., Kavaklioglu, T., Badillo, S., Chavent, M., Saracco, J., Fisher, S. E., Mazoyer, B., & Francks, C. (2018). Atypical lateralization for sentence production, reading, and listening: detection with multivariate clustering and search for associated rare genetic variants using whole genome sequencing. Talk presented at the International Workshop on Imaging Genetics of Human Brain Laterality. Nijmegen, The Netherlands. 2018-01-30.
  • Carrion Castillo, A., Fisher, S. E., & Francks, C. (2018). Planum temporale asymmetry is heritable in the UK biobank (N=12,236). Poster presented at the 26th World Congress of Psychiatric Genetic 2018 (WCPG 2018), Glasgow, UK.
  • Postema, M., Carrion Castillo, A., Fisher, S. E., Vingerhoets, G., & Francks, C. (2018). The genetics of situs inversus totalis without primary ciliary dyskinesia. Talk presented at the MPI workshop "Imaging Genetics of Human Brain Laterality". Nijmegen, The Netherlands. 2018-01-30.
  • Postema, M., Carrion Castillo, A., Fisher, S. E., Vingerhoeds, G., & Francks, C. (2018). The genetics of situs inversus totalis without primary ciliary dyskinesia. Talk presented at the 6th North Sea Laterality International Meeting 2018. Abertay University, Dundee, UK. 2018-08-22 - 2018-08-24.
  • Carrion Castillo, A., Pepe, A., Fisher, S. E., Tzourio-Mazoyer, N., Mazoyer, B., Joliot, M., Crivello, F., & Francks, C. (2017). Heritability analysis of brain laterality indices using the UK biobank dataset. Poster presented at the Cognomics conference 2017, Nijmegen, The Netherlands.
  • Eising, E., Carrion Castillo, A., Vino, A., Shriberg, L. D., & Fisher, S. E. (2017). Childhood apraxia of speech is caused by genes that control gene expression during fetal brain development. Poster presented at the 11th Genomics of Rare Disease conference, Hinxton, UK.
  • Carrion Castillo, A., Heister, A., Naber, M., van der Leij, A., Franke, B., Francks, C., Maassen, B., & Fisher, S. E. (2016). Association analysis of dyslexia candidate genes in a Dutch longitudinal sample. Talk presented at IWORDD - International Workshop on Reading and Developmental Dyslexia. Bilbao, Spain. 2016-05-05 - 2016-05-07.


    Dyslexia is a common learning disability with a known genetic component. Several candidate genes have been implicated in dyslexia susceptibility, such as ROBO1, KIAA0319, and DCDC2. Associations with variants in these genes have also been reported for a variety of psychometric measures that tackle underlying processes that might be impaired in dyslexic people. In this study, we first conducted a literature review to select single nucleotide polymorphisms (SNPs) in dyslexia candidate genes that had been repeatedly implicated in multiple studies. We then assessed the selected SNPs for association in a well-phenotyped longitudinal dataset: the Dutch Dyslexia Program longitudinal sample. We tested for association with several quantitative traits, including word and nonword reading fluency, rapid naming, phoneme deletion and nonword repetition, and took advantage of the longitudinal nature of the sample to examine if associations were stable across four developmental time-points (from 7 to 12 years). Two SNPs in the KIAA0319 gene were found to be nominally associated with rapid naming, and further analysis revealed that these associations were stable across different ages.
  • Carrion Castillo, A., Francks, C., & Fisher, S. E. (2015). Evaluating the genetic risk for dyslexia in multi-generation families. Poster presented at the Individual Differences in Language Processing across the adult Life Span Workshop, Nijmegen, Netherlands.


    Dyslexia or reading disability is a neurodevelopmental condition with a relatively high prevalence in the population (5 - 10% depending on diagnostic criteria). Typically, reading assessment and diagnosis is focused on children, who are categorized as dyslexic if they have reading difficulties that cannot be explained by other factors such as low IQ or other neurological disorders. Although dyslexia can become milder in adulthood, people often retain lifelong difficulties with reading that may affect training, employment and life choices. Dyslexia usually has a complex and multifactorial background that includes genetic contributions. Some unusual families may have relatively rare forms of the disorder that are caused by single genetic mutations with strong effects on reading ability. Here we have focused on extended families with multiple affected members, which may have these kinds of genetic subforms of the disorder. Word and nonword reading fluency measures have been taken for all family members available. We have evaluated these continuous traits across the generations in order to best discriminate affected from unaffected members. We also propose a genetic strategy focused on sequencing the genomes of key members in order to identify possible risk variants. Genes that are found through this approach may be particularly crucial for the development of normal reading and language skills.
  • Carrion Castillo, A., Francks, C., Franke, B., & Fisher, S. E. (2014). Identification of rare variants from exome sequencing in a large family with dyslexia. Poster presented at the 64th Annual Meeting of the American Society of Human Genetics, San Diego, USA.

Share this page