Joery den Hoed

I recently finished my PhD, and I am now working as a postdoc in the Language and Genetics Department.

I completed my Bachelor’s degree in Biology at the Radboud University Nijmegen, and continued with a research Master’s degree in Molecular Mechanisms of Disease at the Radboudumc. During my Master’s program, I worked on research projects at the MPI for Psycholinguistics and at the Department of Physiology, Anatomy and Genetics at the University of Oxford. 

I am particularly interested in how we can employ (high-throughput) cell-based functional assays to learn more about rare mutations disrupting speech and language development - confirming their pathogenicity, explore potential disease mechanisms, but also establish genotype-phenotype correlations. See for example our recent publication about neurodevelopmental disorders associated with the SATB1 gene.

In addition to that, I also work on modelling genetic disruptions using stem-cell based cellular systems. In these projects, I combine CRISPR-Cas9 gene editing with brain organoid models to learn more about gene function during early stages of human brain development.