Publications

Displaying 101 - 200 of 286
  • Klein, W., & Schlieben-Lange, B. (1996). Das Ich und die Sprache. Zeitschrift für Literaturwissenschaft und Linguistik, 101, 1-5.
  • Klein, W., & Rieck, B.-O. (1982). Der Erwerb der Personalpronomina im ungesteuerten Spracherwerb. Zeitschrift für Literaturwissenschaft und Linguistik, 45, 35-71.
  • Klein, W. (1986). Der Wahn vom Sprachverfall und andere Mythen. Zeitschrift für Literaturwissenschaft und Linguistik, 62, 11-28.
  • Klein, W. (1982). Einige Bemerkungen zur Frageintonation. Deutsche Sprache, 4, 289-310.

    Abstract

    In the first, critical part of this study, a small sample of simple German sentences with their empirically determined pitch contours is used to demonstrate the incorrectness of numerous currently hold views of German sentence intonation. In the second, more constructive part, several interrogative sentence types are analysed and an attempt is made to show that intonation, besides other functions, indicates the permantently changing 'thematic score' in on-going discourse as well as certain validity claims.
  • Klein, W. (1982). Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, 12, 7-8.
  • Klein, W. (1986). Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, 16(62), 9-10.
  • Klein, W. (1992). Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, 22(86), 7-8.
  • Klein, W., & Franceschini, R. (Eds.). (2003). Einfache Sprache [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, 131.
  • Klein, W. (1991). Geile Binsenbüschel, sehr intime Gespielen: Ein paar Anmerkungen über Arno Schmidt als Übersetzer. Zeitschrift für Literaturwissenschaft und Linguistik, 84, 124-129.
  • Klein, W. (1997). Learner varieties are the normal case. The Clarion, 3, 4-6.
  • Klein, W. (1997). Nobels Vermächtnis, oder die Wandlungen des Idealischen. Zeitschrift für Literaturwissenschaft und Linguistik, 107, 6-18.

    Abstract

    Nobel's legacy, or the metamorphosis of what is idealistic Ever since the first Nobel prize in literature was awarded to Prudhomme in 1901, the decisions of the Swedish Academy have been subject to criticism. What is surprising in the changing decision policy as well as in its criticism is the fact that Alfred Nobel's original intentions are hardly ever taken into account: the Nobel prize is a philanthropic prize, it is not meant to select and honour the most eminent literary work but the work with maximal benefit to human beings. What is even more surprising is the fact that no one seems to care that the donator's Last Will is regularly broken.
  • Klein, W. (1982). Pronoms personnels et formes d'acquisition. Encrages, 8/9, 42-46.
  • Klein, W. (1991). Raumausdrücke. Linguistische Berichte, 132, 77-114.
  • Klein, W. (Ed.). (1997). Technologischer Wandel in den Philologien [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (106).
  • Klein, W. (1992). Tempus, Aspekt und Zeitadverbien. Kognitionswissenschaft, 2, 107-118.
  • Klein, W., & Von Stutterheim, C. (1991). Text structure and referential movement. Arbeitsberichte des Forschungsprogramms S&P: Sprache und Pragmatik, 22.
  • Klein, W. (Ed.). (1992). Textlinguistik [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (86).
  • Klein, W., & Von Stutterheim, C. (1992). Textstruktur und referentielle Bewegung. Zeitschrift für Literaturwissenschaft und Linguistik, 86, 67-92.
  • Klein, W., & Perdue, C. (1997). The basic variety (or: Couldn't natural languages be much simpler?). Second Language Research, 13, 301-347. doi:10.1191/026765897666879396.

    Abstract

    In this article, we discuss the implications of the fact that adult second language learners (outside the classroom) universally develop a well-structured, efficient and simple form of language–the Basic Variety (BV). Three questions are asked as to (1) the structural properties of the BV, (2) the status of these properties and (3) why some structural properties of ‘fully fledged’ languages are more complex. First, we characterize the BV in four respects: its lexical repertoire, the principles according to which utterances are structured, and temporality and spatiality expressed. The organizational principles proposed are small in number, and interact. We analyse this interaction, describing how the BV is put to use in various complex verbal tasks, in order to establish both what its communicative potentialities are, and also those discourse contexts where the constraints come into conflict and where the variety breaks down. This latter phenomenon provides a partial answer to the third question,concerning the relative complexity of ‘fully fledged’ languages–they have devices to deal with such cases. As for the second question, it is argued firstly that the empirically established continuity of the adult acquisition process precludes any assignment of the BV to a mode of linguistic expression (e.g., ‘protolanguage’) distinct from that of ‘fully fledged’ languages and, moreover, that the organizational constraints of the BV belong to the core attributes of the human language capacity, whereas a number of complexifications not attested in the BV are less central properties of this capacity. Finally, it is shown that the notion of feature strength, as used in recent versions of Generative Grammar, allows a straightforward characterization of the BV as a special case of an I-language, in the sense of this theory. Under this perspective, the acquisition of an Ilanguage beyond the BV can essentially be described as a change in feature strength.
  • Klein, W., & Schlieben-Lange, B. (Eds.). (1996). Sprache und Subjektivität I [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (101).
  • Klein, W., & Schlieben-Lange, B. (Eds.). (1996). Sprache und Subjektivität II [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (102).
  • Klein, W. (Ed.). (1986). Sprachverfall [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (62).
  • Klein, W. (1992). The present perfect puzzle. Language, 68, 525-552.

    Abstract

    In John has left London, it is clear that the event in question, John's leaving London, has occurred in the past, for example yesterday at ten. Why is it impossible, then, to make this the event time more explicit by such an adverbial, as in Yesterday at ten, John has left London? Any solution of this puzzle crucially hinges on the meaning assigned to the perfect, and the present perfect in particular. Two such solutions, a scope solution and the 'current relevance'-solution, are discussed and shown to be inadequate. A new, strictly compositional analysis of the English perfect is suggested, and it is argued that the imcompatibility of the present perfect and most past tense adverbials has neither syntactic nor semantic reasons but follows from a simple pragmatical constraint, called here the 'position-definiteness constraint'. It is the very same constraint, which also makes an utterance such as At ten, John had left at nine pragmatically odd, even if John indeed had left at nine, and hence the utterance is true.
  • Klein, W. (1991). Was kann sich die Übersetzungswissenschaft von der Linguistik erwarten? Zeitschrift für Literaturwissenschaft und Linguistik, 84, 104-123.
  • Klein, W. (Ed.). (1996). Zweitspracherwerb [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (104).
  • Klein, W. (Ed.). (1982). Zweitspracherwerb [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (45).
  • Klein, W. (1986). Über Ansehen und Wirkung der deutschen Sprachwissenschaft heute. Linguistische Berichte, 100, 511-520.
  • Lai, C. S. L., Gerrelli, D., Monaco, A. P., Fisher, S. E., & Copp, A. J. (2003). FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder. Brain, 126(11), 2455-2462. doi:10.1093/brain/awg247.

    Abstract

    Disruption of FOXP2, a gene encoding a forkhead-domain transcription factor, causes a severe developmental disorder of verbal communication, involving profound articulation deficits, accompanied by linguistic and grammatical impairments. Investigation of the neural basis of this disorder has been limited previously to neuroimaging of affected children and adults. The discovery of the gene responsible, FOXP2, offers a unique opportunity to explore the relevant neural mechanisms from a molecular perspective. In the present study, we have determined the detailed spatial and temporal expression pattern of FOXP2 mRNA in the developing brain of mouse and human. We find expression in several structures including the cortical plate, basal ganglia, thalamus, inferior olives and cerebellum. These data support a role for FOXP2 in the development of corticostriatal and olivocerebellar circuits involved in motor control. We find intriguing concordance between regions of early expression and later sites of pathology suggested by neuroimaging. Moreover, the homologous pattern of FOXP2/Foxp2 expression in human and mouse argues for a role for this gene in development of motor-related circuits throughout mammalian species. Overall, this study provides support for the hypothesis that impairments in sequencing of movement and procedural learning might be central to the FOXP2-related speech and language disorder.
  • Lausberg, H., Cruz, R. F., Kita, S., Zaidel, E., & Ptito, A. (2003). Pantomime to visual presentation of objects: Left hand dyspraxia in patients with complete callosotomy. Brain, 126(2), 343-360. doi:10.1093/brain/awg042.

    Abstract

    Investigations of left hand praxis in imitation and object use in patients with callosal disconnection have yielded divergent results, inducing a debate between two theoretical positions. Whereas Liepmann suggested that the left hemisphere is motor dominant, others maintain that both hemispheres have equal motor competences and propose that left hand apraxia in patients with callosal disconnection is secondary to left hemispheric specialization for language or other task modalities. The present study aims to gain further insight into the motor competence of the right hemisphere by investigating pantomime of object use in split-brain patients. Three patients with complete callosotomy and, as control groups, five patients with partial callosotomy and nine healthy subjects were examined for their ability to pantomime object use to visual object presentation and demonstrate object manipulation. In each condition, 11 objects were presented to the subjects who pantomimed or demonstrated the object use with either hand. In addition, six object pairs were presented to test bimanual coordination. Two independent raters evaluated the videotaped movement demonstrations. While object use demonstrations were perfect in all three groups, the split-brain patients displayed apraxic errors only with their left hands in the pantomime condition. The movement analysis of concept and execution errors included the examination of ipsilateral versus contralateral motor control. As the right hand/left hemisphere performances demonstrated retrieval of the correct movement concepts, concept errors by the left hand were taken as evidence for right hemisphere control. Several types of execution errors reflected a lack of distal motor control indicating the use of ipsilateral pathways. While one split-brain patient controlled his left hand predominantly by ipsilateral pathways in the pantomime condition, the error profile in the other two split-brain patients suggested that the right hemisphere controlled their left hands. In the object use condition, in all three split-brain patients fine-graded distal movements in the left hand indicated right hemispheric control. Our data show left hand apraxia in split-brain patients is not limited to verbal commands, but also occurs in pantomime to visual presentation of objects. As the demonstration with object in hand was unimpaired in either hand, both hemispheres must contain movement concepts for object use. However, the disconnected right hemisphere is impaired in retrieving the movement concept in response to visual object presentation, presumably because of a deficit in associating perceptual object representation with the movement concepts.
  • Lausberg, H., Kita, S., Zaidel, E., & Ptito, A. (2003). Split-brain patients neglect left personal space during right-handed gestures. Neuropsychologia, 41(10), 1317-1329. doi:10.1016/S0028-3932(03)00047-2.

    Abstract

    Since some patients with right hemisphere damage or with spontaneous callosal disconnection neglect the left half of space, it has been suggested that the left cerebral hemisphere predominantly attends to the right half of space. However, clinical investigations of patients having undergone surgical callosal section have not shown neglect when the hemispheres are tested separately. These observations question the validity of theoretical models that propose a left hemispheric specialisation for attending to the right half of space. The present study aims to investigate neglect and the use of space by either hand in gestural demonstrations in three split-brain patients as compared to five patients with partial callosotomy and 11 healthy subjects. Subjects were asked to demonstrate with precise gestures and without speaking the content of animated scenes with two moving objects. The results show that in the absence of primary perceptual or representational neglect, split-brain patients neglect left personal space in right-handed gestural demonstrations. Since this neglect of left personal space cannot be explained by directional or spatial akinesia, it is suggested that it originates at the conceptual level, where the spatial coordinates for right-hand gestures are planned. The present findings are at odds with the position that the separate left hemisphere possesses adequate mechanisms for acting in both halves of space and neglect results from right hemisphere suppression of this potential. Rather, the results provide support for theoretical models that consider the left hemisphere as specialised for processing the right half of space during the execution of descriptive gestures.
  • Lausberg, H., & Kita, S. (2003). The content of the message influences the hand choice in co-speech gestures and in gesturing without speaking. Brain and Language, 86(1), 57-69. doi:10.1016/S0093-934X(02)00534-5.

    Abstract

    The present study investigates the hand choice in iconic gestures that accompany speech. In 10 right-handed subjects gestures were elicited by verbal narration and by silent gestural demonstrations of animations with two moving objects. In both conditions, the left-hand was used as often as the right-hand to display iconic gestures. The choice of the right- or left-hands was determined by semantic aspects of the message. The influence of hemispheric language lateralization on the hand choice in co-speech gestures appeared to be minor. Instead, speaking seemed to induce a sequential organization of the iconic gestures.
  • De León, L., & Levinson, S. C. (Eds.). (1992). Space in Mesoamerican languages [Special Issue]. Zeitschrift für Phonetik, Sprachwissenschaft und Kommunikationsforschung, 45(6).
  • Levelt, W. J. M. (1996). Hoedt u voor neurolinguïstisch programmeren. Actieblad tegen de kwakzalverij, 107, 12-14.
  • Levelt, W. J. M. (1992). Accessing words in speech production: Stages, processes and representations. Cognition, 42, 1-22. doi:10.1016/0010-0277(92)90038-J.

    Abstract

    This paper introduces a special issue of Cognition on lexical access in speech production. Over the last quarter century, the psycholinguistic study of speaking, and in particular of accessing words in speech, received a major new impetus from the analysis of speech errors, dysfluencies and hesitations, from aphasiology, and from new paradigms in reaction time research. The emerging theoretical picture partitions the accessing process into two subprocesses, the selection of an appropriate lexical item (a “lemma”) from the mental lexicon, and the phonological encoding of that item, that is, the computation of a phonetic program for the item in the context of utterance. These two theoretical domains are successively introduced by outlining some core issues that have been or still have to be addressed. The final section discusses the controversial question whether phonological encoding can affect lexical selection. This partitioning is also followed in this special issue as a whole. There are, first, four papers on lexical selection, then three papers on phonological encoding, and finally one on the interaction between selection and phonological encoding.
  • Levelt, W. J. M. (1991). Die konnektionistische Mode. Sprache und Kognition, 10(2), 61-72.
  • Levelt, W. J. M. (1992). Fairness in reviewing: A reply to O'Connell. Journal of Psycholinguistic Research, 21, 401-403.
  • Levelt, W. J. M. (1997). Kunnen lezen is ongewoon voor horenden en doven. Tijdschrift voor Jeugdgezondheidszorg, 29(2), 22-25.
  • Levelt, W. J. M. (1982). Het lineariseringsprobleem van de spreker. Tijdschrift voor Taal- en Tekstwetenschap (TTT), 2(1), 1-15.
  • Levelt, W. J. M., Schriefers, H., Vorberg, D., Meyer, A. S., Pechmann, T., & Havinga, J. (1991). Normal and deviant lexical processing: Reply to Dell and O'Seaghdha. Psychological Review, 98(4), 615-618. doi:10.1037/0033-295X.98.4.615.

    Abstract

    In their comment, Dell and O'Seaghdha (1991) adduced any effect on phonological probes for semantic alternatives to the activation of these probes in the lexical network. We argue that that interpretation is false and, in addition, that the model still cannot account for our data. Furthermore, and different from Dell and O'seaghda, we adduce semantic rebound to the lemma level, where it is so substantial that it should have shown up in our data. Finally, we question the function of feedback in a lexical network (other than eliciting speech errors) and discuss Dell's (1988) notion of a unified production-comprehension system.
  • Levelt, W. J. M. (1992). Sprachliche Musterbildung und Mustererkennung. Nova Acta Leopoldina NF, 67(281), 357-370.
  • Levelt, W. J. M., & Kelter, S. (1982). Surface form and memory in question answering. Cognitive Psychology, 14, 78-106. doi:10.1016/0010-0285(82)90005-6.

    Abstract

    Speakers tend to repeat materials from previous talk. This tendency is experimentally established and manipulated in various question-answering situations. It is shown that a question's surface form can affect the format of the answer given, even if this form has little semantic or conversational consequence, as in the pair Q: (At) what time do you close. A: “(At)five o'clock.” Answerers tend to match the utterance to the prepositional (nonprepositional) form of the question. This “correspondence effect” may diminish or disappear when, following the question, additional verbal material is presented to the answerer. The experiments show that neither the articulatory buffer nor long-term memory is normally involved in this retention of recent speech. Retaining recent speech in working memory may fulfill a variety of functions for speaker and listener, among them the correct production and interpretation of surface anaphora. Reusing recent materials may, moreover, be more economical than regenerating speech anew from a semantic base, and thus contribute to fluency. But the realization of this strategy requires a production system in which linguistic formulation can take place relatively independent of, and parallel to, conceptual planning.
  • Levelt, W. J. M. (1982). Science policy: Three recent idols, and a goddess. IPO Annual Progress Report, 17, 32-35.
  • Levelt, W. J. M. (1992). The perceptual loop theory not disconfirmed: A reply to MacKay. Consciousness and Cognition, 1, 226-230. doi:10.1016/1053-8100(92)90062-F.

    Abstract

    In his paper, MacKay reviews his Node Structure theory of error detection, but precedes it with a critical discussion of the Perceptual Loop theory of self-monitoring proposed in Levelt (1983, 1989). The present commentary is concerned with this latter critique and shows that there are more than casual problems with MacKay’s argumentation.
  • Levelt, W. J. M. (1996). Waar komen gesproken woorden vandaan? De Psycholoog, 31, 434-437.
  • Levelt, W. J. M., Schriefer, H., Vorberg, D., Meyer, A. S., Pechmann, T., & Havinga, J. (1991). The time course of lexical access in speech production: A study of picture naming. Psychological Review, 98(1), 122-142. doi:10.1037/0033-295X.98.1.122.
  • Levelt, W. J. M. (1982). Zelfcorrecties in het spreekproces. KNAW: Mededelingen van de afdeling letterkunde, nieuwe reeks, 45(8), 215-228.
  • Levinson, S. C., & Brown, P. (2003). Emmanuel Kant chez les Tenejapans: L'Anthropologie comme philosophie empirique [Translated by Claude Vandeloise for 'Langues et Cognition']. Langues et Cognition, 239-278.

    Abstract

    This is a translation of Levinson and Brown (1994).
  • Levinson, S. C., & Meira, S. (2003). 'Natural concepts' in the spatial topological domain - adpositional meanings in crosslinguistic perspective: An exercise in semantic typology. Language, 79(3), 485-516.

    Abstract

    Most approaches to spatial language have assumed that the simplest spatial notions are (after Piaget) topological and universal (containment, contiguity, proximity, support, represented as semantic primitives suchas IN, ON, UNDER, etc.). These concepts would be coded directly in language, above all in small closed classes suchas adpositions—thus providing a striking example of semantic categories as language-specific projections of universal conceptual notions. This idea, if correct, should have as a consequence that the semantic categories instantiated in spatial adpositions should be essentially uniform crosslinguistically. This article attempts to verify this possibility by comparing the semantics of spatial adpositions in nine unrelated languages, with the help of a standard elicitation procedure, thus producing a preliminary semantic typology of spatial adpositional systems. The differences between the languages turn out to be so significant as to be incompatible withstronger versions of the UNIVERSAL CONCEPTUAL CATEGORIES hypothesis. Rather, the language-specific spatial adposition meanings seem to emerge as compact subsets of an underlying semantic space, withcertain areas being statistical ATTRACTORS or FOCI. Moreover, a comparison of systems withdifferent degrees of complexity suggests the possibility of positing implicational hierarchies for spatial adpositions. But such hierarchies need to be treated as successive divisions of semantic space, as in recent treatments of basic color terms. This type of analysis appears to be a promising approachfor future work in semantic typology.
  • Levinson, S. C., & Senft, G. (1991). Forschungsgruppe für Kognitive Anthropologie - Eine neue Forschungsgruppe in der Max-Planck-Gesellschaft. Linguistische Berichte, 133, 244-246.
  • Levinson, S. C. (1997). Language and cognition: The cognitive consequences of spatial description in Guugu Yimithirr. Journal of Linguistic Anthropology, 7(1), 98-131. doi:10.1525/jlin.1997.7.1.98.

    Abstract

    This article explores the relation between language and cognition by examining the case of "absolute" (cardinal direction) spatial description in the Australian aboriginal language Guugu Yimithirr. This kind of spatial description is incongruent with the "relative" (e.g., left/right/front/back) spatial description familiar in European languages. Building on Haviland's 1993 analysis of Guugu Yimithirr directionals in speech and gesture, a series of informal experiments were developed. It is shown that Guugu Yimithirr speakers predominantly code for nonverbal memory in "absolute" concepts congruent with their language, while a comparative sample of Dutch speakers do so in "relative" concepts. Much anecdotal evidence also supports this. The conclusion is that Whorfian effects may in fact be demonstrable in the spatial domain.
  • Levinson, S. C. (1997). Language and cognition: The cognitive consequences of spatial description in Guugu Yimithirr. Journal of Linguistic Anthropology, 7(1), 1-35. doi:10.1525/jlin.1997.7.1.98.
  • Levinson, S. C. (1996). Language and space. Annual Review of Anthropology, 25, 353-382. doi:10.1146/annurev.anthro.25.1.353.

    Abstract

    This review describes some recent, unexpected findings concerning variation in spatial language across cultures, and places them in the context of the general anthropology of space on the one hand, and theories of spatial cognition in the cognitive sciences on the other. There has been much concern with the symbolism of space in anthropological writings, but little on concepts of space in practical activities. This neglect of everyday spatial notions may be due to unwitting ethnocentrism, the assumption in Western thinking generally that notions of space are universally of a single kind. Recent work shows that systems of spatial reckoning and description can in fact be quite divergent across cultures, linguistic differences correlating with distinct cognitive tendencies. This unexpected cultural variation raises interesting questions concerning the relation between cultural and linguistic concepts and the biological foundations of cognition. It argues for more sophisticated models relating culture and cognition than we currently have available.
  • Levinson, S. C. (1992). Primer for the field investigation of spatial description and conception. Pragmatics, 2(1), 5-47.
  • Levinson, S. C., & Senft, G. (1991). Research group for cognitive anthropology - A new research group of the Max Planck Society. Cognitive Linguistics, 2, 311-312.
  • Levinson, S. C. (1991). Pragmatic reduction of the Binding Conditions revisited. Journal of Linguistics, 27, 107-161. doi:10.1017/S0022226700012433.

    Abstract

    In an earlier article (Levinson, 1987b), I raised the possibility that a Gricean theory of implicature might provide a systematic partial reduction of the Binding Conditions; the briefest of outlines is given in Section 2.1 below but the argumentation will be found in the earlier article. In this article I want, first, to show how that account might be further justified and extended, but then to introduce a radical alternative. This alternative uses the same pragmatic framework, but gives an account better adjusted to some languages. Finally, I shall attempt to show that both accounts can be combined by taking a diachronic perspective. The attraction of the combined account is that, suddenly, many facts about long-range reflexives and their associated logophoricity fall into place.
  • Lieber, R., & Baayen, R. H. (1997). A semantic principle of auxiliary selection in Dutch. Natural Language & Linguistic Theory, 15(4), 789-845.

    Abstract

    We propose that the choice between the auxiliaries hebben 'have' and zijn 'be' in Dutch is determined by a particular semantic feature of verbs. In particular we propose a feature of meaning [IEPS] for 'inferable eventual position or state' that characterizes whether the action denoted by the verb allows us to determine the eventual position or state of the verb's highest argument. It is argued that only verbs which exhibit the feature [+IEPS] or which obtain the feature compositionally in the syntax select zijn as their auxiliary. Our analysis is then compared to a number of other analyses of auxiliary selection in Dutch.

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  • Lloyd, S. E., Günther, W., Pearce, S. H. S., Thomson, A., Bianchi, M. L., Bosio, M., Craig, I. W., Fisher, S. E., Scheinman, S. J., Wrong, O., Jentsch, T. J., & Thakker, R. V. (1997). Characterisation of renal chloride channel, CLCN5, mutations in hypercalciuric nephrolithiasis (kidney stones) disorders. Human Molecular Genetics, 6(8), 1233-1239. doi:10.1093/hmg/6.8.1233.

    Abstract

    Mutations of the renal-specific chloride channel (CLCN5) gene, which is located on chromosome Xp11.22, are associated with hypercalciuric nephrolithiasis (kidney stones) in the Northern European and Japanese populations. CLCN5 encodes a 746 amino acid channel (CLC-5) that has approximately 12 transmembrane domains, and heterologous expression of wild-type CLC-5 in Xenopus oocytes has yielded outwardly rectifying chloride currents that were markedly reduced or abolished by these mutations. In order to assess further the structural and functional relationships of this recently cloned chloride channel, additional CLCN5 mutations have been identified in five unrelated families with this disorder. Three of these mutations were missense (G57V, G512R and E527D), one was a nonsense (R648Stop) and one was an insertion (30:H insertion). In addition, two of the mutations (30:H insertion and E527D) were demonstrated to be de novo, and the G57V and E527D mutations were identified in families of Afro-American and Indian origin, respectively. The G57V and 30:H insertion mutations represent the first CLCN5 mutations to be identified in the N-terminus region, and the R648Stop mutation, which has been observed previously in an unrelated family, suggests that this codon may be particularly prone to mutations. Heterologous expression of the mutations resulted in a marked reduction or abolition of the chloride currents, thereby establishing their functional importance. These results help to elucidate further the structure-function relationships of this renal chloride channel.
  • Lloyd, S. E., Pearce, S. H. S., Fisher, S. E., Steinmeyer, K., Schwappach, B., Scheinman, S. J., Harding, B., Bolino, A., Devoto, M., Goodyer, P., Rigden, S. P. A., Wrong, O., Jentsch, T. J., Craig, I. W., & Thakker, R. V. (1996). A common molecular basis for three inherited kidney stone diseases [Letter to Nature]. Nature, 379, 445 -449. doi:10.1038/379445a0.

    Abstract

    Kidney stones (nephrolithiasis), which affect 12% of males and 5% of females in the western world, are familial in 45% of patients and are most commonly associated with hypercalciuria. Three disorders of hypercalciuric nephrolithiasis (Dent's disease, X-linked recessive nephrolithiasis (XRN), and X-linked recessive hypophosphataemic rickets (XLRH)) have been mapped to Xp11.22 (refs 5-7). A microdeletion in one Dent's disease kindred allowed the identification of a candidate gene, CLCN5 (refs 8,9) which encodes a putative renal chloride channel. Here we report the investigation of 11 kindreds with these renal tubular disorders for CLCN5 abnormalities; this identified three nonsense, four missense and two donor splice site mutations, together with one intragenic deletion and one microdeletion encompassing the entire gene. Heterologous expression of wild-type CLCN5 in Xenopus oocytes yielded outwardly rectifying chloride currents, which were either abolished or markedly reduced by the mutations. The common aetiology for Dent's disease, XRN and XLRH indicates that CLCN5 may be involved in other renal tubular disorders associated with kidney stones
  • Lundstrom, B. N., Petersson, K. M., Andersson, J., Johansson, M., Fransson, P., & Ingvar, M. (2003). Isolating the retrieval of imagined pictures during episodic memory: Activation of the left precuneus and left prefrontal cortex. Neuroimage, 20, 1934-1943. doi:10.1016/j.neuroimage.2003.07.017.

    Abstract

    The posterior medial parietal cortex and the left prefrontal cortex have both been implicated in the recollection of past episodes. In order to clarify their functional significance, we performed this functional magnetic resonance imaging study, which employed event-related source memory and item recognition retrieval of words paired with corresponding imagined or viewed pictures. Our results suggest that episodic source memory is related to a functional network including the posterior precuneus and the left lateral prefrontal cortex. This network is activated during explicit retrieval of imagined pictures and results from the retrieval of item-context associations. This suggests that previously imagined pictures provide a context with which encoded words can be more strongly associated.
  • Mace, R., Jordan, F., & Holden, C. (2003). Testing evolutionary hypotheses about human biological adaptation using cross-cultural comparison. Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology, 136(1), 85-94. doi:10.1016/S1095-6433(03)00019-9.

    Abstract

    Physiological data from a range of human populations living in different environments can provide valuable information for testing evolutionary hypotheses about human adaptation. By taking into account the effects of population history, phylogenetic comparative methods can help us determine whether variation results from selection due to particular environmental variables. These selective forces could even be due to cultural traits-which means that gene-culture co-evolution may be occurring. In this paper, we outline two examples of the use of these approaches to test adaptive hypotheses that explain global variation in two physiological traits: the first is lactose digestion capacity in adults, and the second is population sex-ratio at birth. We show that lower than average sex ratio at birth is associated with high fertility, and argue that global variation in sex ratio at birth has evolved as a response to the high physiological costs of producing boys in high fertility populations.
  • Magnuson, J. S., Tanenhaus, M. K., Aslin, R. N., & Dahan, D. (2003). The time course of spoken word learning and recognition: Studies with artificial lexicons. Journal of Experimental Psychology: General, 132(2), 202-227. doi:10.1037/0096-3445.132.2.202.

    Abstract

    The time course of spoken word recognition depends largely on the frequencies of a word and its competitors, or neighbors (similar-sounding words). However, variability in natural lexicons makes systematic analysis of frequency and neighbor similarity difficult. Artificial lexicons were used to achieve precise control over word frequency and phonological similarity. Eye tracking provided time course measures of lexical activation and competition (during spoken instructions to perform visually guided tasks) both during and after word learning, as a function of word frequency, neighbor type, and neighbor frequency. Apparent shifts from holistic to incremental competitor effects were observed in adults and neural network simulations, suggesting such shifts reflect general properties of learning rather than changes in the nature of lexical representations.
  • Magyari, L. (2003). Mit ne gondoljunk az állatokról? [What not to think about animals?] [Review of the book Wild Minds: What animals really think by M. Hauser]. Magyar Pszichológiai Szemle (Hungarian Psychological Review), 58(3), 417-424. doi:10.1556/MPSzle.58.2003.3.5.
  • Majid, A. (2003). Towards behavioural genomics. The Psychologist, 16(6), 298-298.
  • Majid, A. (2003). Into the deep. The Psychologist, 16(6), 300-300.
  • Mangione-Smith, R., Stivers, T., Elliott, M. N., McDonald, L., & Heritage, J. (2003). Online commentary during the physical examination: A communication tool for avoiding inappropriate antibiotic prescribing? Social Science and Medicine, 56(2), 313-320.
  • Marcus, G. F., & Fisher, S. E. (2003). FOXP2 in focus: What can genes tell us about speech and language? Trends in Cognitive Sciences, 7, 257-262. doi:10.1016/S1364-6613(03)00104-9.

    Abstract

    The human capacity for acquiring speech and language must derive, at least in part, from the genome. In 2001, a study described the first case of a gene, FOXP2, which is thought to be implicated in our ability to acquire spoken language. In the present article, we discuss how this gene was discovered, what it might do, how it relates to other genes, and what it could tell us about the nature of speech and language development. We explain how FOXP2 could, without being specific to the brain or to our own species, still provide an invaluable entry-point into understanding the genetic cascades and neural pathways that contribute to our capacity for speech and language.
  • Marlow, A. J., Fisher, S. E., Francks, C., MacPhie, I. L., Cherny, S. S., Richardson, A. J., Talcott, J. B., Stein, J. F., Monaco, A. P., & Cardon, L. R. (2003). Use of multivariate linkage analysis for dissection of a complex cognitive trait. American Journal of Human Genetics, 72(3), 561-570. doi:10.1086/368201.

    Abstract

    Replication of linkage results for complex traits has been exceedingly difficult, owing in part to the inability to measure the precise underlying phenotype, small sample sizes, genetic heterogeneity, and statistical methods employed in analysis. Often, in any particular study, multiple correlated traits have been collected, yet these have been analyzed independently or, at most, in bivariate analyses. Theoretical arguments suggest that full multivariate analysis of all available traits should offer more power to detect linkage; however, this has not yet been evaluated on a genomewide scale. Here, we conduct multivariate genomewide analyses of quantitative-trait loci that influence reading- and language-related measures in families affected with developmental dyslexia. The results of these analyses are substantially clearer than those of previous univariate analyses of the same data set, helping to resolve a number of key issues. These outcomes highlight the relevance of multivariate analysis for complex disorders for dissection of linkage results in correlated traits. The approach employed here may aid positional cloning of susceptibility genes in a wide spectrum of complex traits.
  • McQueen, J. M. (2003). The ghost of Christmas future: Didn't Scrooge learn to be good? Commentary on Magnuson, McMurray, Tanenhaus and Aslin (2003). Cognitive Science, 27(5), 795-799. doi:10.1207/s15516709cog2705_6.

    Abstract

    Magnuson, McMurray, Tanenhaus, and Aslin [Cogn. Sci. 27 (2003) 285] suggest that they have evidence of lexical feedback in speech perception, and that this evidence thus challenges the purely feedforward Merge model [Behav. Brain Sci. 23 (2000) 299]. This evidence is open to an alternative explanation, however, one which preserves the assumption in Merge that there is no lexical-prelexical feedback during on-line speech processing. This explanation invokes the distinction between perceptual processing that occurs in the short term, as an utterance is heard, and processing that occurs over the longer term, for perceptual learning.
  • McQueen, J. M., Cutler, A., & Norris, D. (2003). Flow of information in the spoken word recognition system. Speech Communication, 41(1), 257-270. doi:10.1016/S0167-6393(02)00108-5.

    Abstract

    Spoken word recognition consists of two major component processes. First, at the prelexical stage, an abstract description of the utterance is generated from the information in the speech signal. Second, at the lexical stage, this description is used to activate all the words stored in the mental lexicon which match the input. These multiple candidate words then compete with each other. We review evidence which suggests that positive (match) and negative (mismatch) information of both a segmental and a suprasegmental nature is used to constrain this activation and competition process. We then ask whether, in addition to the necessary influence of the prelexical stage on the lexical stage, there is also feedback from the lexicon to the prelexical level. In two phonetic categorization experiments, Dutch listeners were asked to label both syllable-initial and syllable-final ambiguous fricatives (e.g., sounds ranging from [f] to [s]) in the word–nonword series maf–mas, and the nonword–word series jaf–jas. They tended to label the sounds in a lexically consistent manner (i.e., consistent with the word endpoints of the series). These lexical effects became smaller in listeners’ slower responses, even when the listeners were put under pressure to respond as fast as possible. Our results challenge models of spoken word recognition in which feedback modulates the prelexical analysis of the component sounds of a word whenever that word is heard
  • Meeuwissen, M., Roelofs, A., & Levelt, W. J. M. (2003). Planning levels in naming and reading complex numerals. Memory & Cognition, 31(8), 1238-1249.

    Abstract

    On the basis of evidence from studies of the naming and reading of numerals, Ferrand (1999) argued that the naming of objects is slower than reading their names, due to a greater response uncertainty in naming than in reading, rather than to an obligatory conceptual preparation for naming, but not for reading. We manipulated the need for conceptual preparation, while keeping response uncertainty constant in the naming and reading of complex numerals. In Experiment 1, participants named three-digit Arabic numerals either as house numbers or clock times. House number naming latencies were determined mostly by morphophonological factors, such as morpheme frequency and the number of phonemes, whereas clock time naming latencies revealed an additional conceptual involvement. In Experiment 2, the numerals were presented in alphabetic format and had to be read aloud. Reading latencies were determined mostly by morphophonological factors in both modes. These results suggest that conceptual preparation, rather than response uncertainty, is responsible for the difference between naming and reading latencies.
  • Meyer, A. S., Roelofs, A., & Levelt, W. J. M. (2003). Word length effects in object naming: The role of a response criterion. Journal of Memory and Language, 48(1), 131-147. doi:10.1016/S0749-596X(02)00509-0.

    Abstract

    According to Levelt, Roelofs, and Meyer (1999) speakers generate the phonological and phonetic representations of successive syllables of a word in sequence and only begin to speak after having fully planned at least one complete phonological word. Therefore, speech onset latencies should be longer for long than for short words. We tested this prediction in four experiments in which Dutch participants named or categorized objects with monosyllabic or disyllabic names. Experiment 1 yielded a length effect on production latencies when objects with long and short names were tested in separate blocks, but not when they were mixed. Experiment 2 showed that the length effect was not due to a difference in the ease of object recognition. Experiment 3 replicated the results of Experiment 1 using a within-participants design. In Experiment 4, the long and short target words appeared in a phrasal context. In addition to the speech onset latencies, we obtained the viewing times for the target objects, which have been shown to depend on the time necessary to plan the form of the target names. We found word length effects for both dependent variables, but only when objects with short and long names were presented in separate blocks. We argue that in pure and mixed blocks speakers used different response deadlines, which they tried to meet by either generating the motor programs for one syllable or for all syllables of the word before speech onset. Computer simulations using WEAVER++ support this view.
  • Meyer, A. S. (1997). Conceptual influences on grammatical planning units. Language and Cognitive Processes, 12, 859-863. doi:10.1080/016909697386745.
  • Meyer, A. S., Levelt, W. J. M., & Wissink, M. T. (1996). Een modulair model van zinsproductie. Logopedie, 9(2), 21-31.

    Abstract

    In deze bijdrage wordt een modulair model van zinsproductie besproken. De planningsprocessen, die aan de productie van een zin voorafgaan, kunnen in twee hoofdcomponenten onderverdeeld worden: deconceptualisering (het bedenken van de inhoud van de uiting) en de formulering (het vastleggen van de linguïstische vorm). Het formuleringsproces bestaat weer uit twee componenten, te weten de grammatische en fonologische codering. Ook deze componenten bestaan elk weer uit een aantal subcomponenten. Dit artikel beschrijft wat de specifieke taak van iedere component is, hoe deze uitgevoerd wordt en hoe de componenten samenwerken. Tevens worden enkele belangrijke methoden van taalproductie-onderzoek besproken.
  • Meyer, A. S. (1996). Lexical access in phrase and sentence production: Results from picture-word interference experiments. Journal of Memory and Language, 35, 477-496. doi:doi:10.1006/jmla.1996.0026.

    Abstract

    Four experiments investigated the span of advance planning for phrases and short sentences. Dutch subjects were presented with pairs of objects, which they named using noun-phrase conjunctions (e.g., the translation equivalent of ''the arrow and the bag'') or sentences (''the arrow is next to the bag''). Each display was accompanied by an auditory distracter, which was related in form or meaning to the first or second noun of the utterance or unrelated to both. For sentences and phrases, the mean speech onset time was longer when the distracter was semantically related to the first or second noun and shorter when it was phonologically related to the first noun than when it was unrelated. No phonological facilitation was found for the second noun. This suggests that before utterance onset both target lemmas and the first target form were selected.
  • Meyer, A. S. (1992). Investigation of phonological encoding through speech error analyses: Achievements, limitations, and alternatives. Cognition, 42, 181-211. doi:10.1016/0010-0277(92)90043-H.

    Abstract

    Phonological encoding in language production can be defined as a set of processes generating utterance forms on the basis of semantic and syntactic information. Most evidence about these processes stems from analyses of sound errors. In section 1 of this paper, certain important results of these analyses are reviewed. Two prominent models of phonological encoding, which are mainly based on speech error evidence, are discussed in section 2. In section 3, limitations of speech error analyses are discussed, and it is argued that detailed and comprehensive models of phonological encoding cannot be derived solely on the basis of error analyses. As is argued in section 4, a new research strategy is required. Instead of using the properties of errors to draw inferences about the generation of correct word forms, future research should directly investigate the normal process of phonological encoding.
  • Meyer, A. S., & Schriefers, H. (1991). Phonological facilitation in picture-word interference experiments: Effects of stimulus onset asynchrony and types of interfering stimuli. Journal of Experimental Psychology: Learning, Memory, and Cognition, 17, 1146-1160. doi:10.1037/0278-7393.17.6.1146.

    Abstract

    Subjects named pictures while hearing distractor words that shared word-initial or word-final segments with the picture names or were unrelated to the picture names. The relative timing of distractor and picture presentation was varied. Compared with unrelated distractors, both types of related distractors facilitated picture naming under certain timing conditions. Begin-related distractors facilitated the naming responses if the shared segments began 150 ms before, at, or 150 ms after picture onset. By contrast, end-related distractors only facilitated the responses if the shared segments began at or 150 ms after picture onset. The results suggest that the phonological encoding of the beginning of a word is initiated before the encoding of its end.
  • Meyer, A. S. (1991). The time course of phonological encoding in language production: Phonological encoding inside a syllable. Journal of Memory and Language, 30, 69-69. doi:10.1016/0749-596X(91)90011-8.

    Abstract

    Eight experiments were carried out investigating whether different parts of a syllable must be phonologically encoded in a specific order or whether they can be encoded in any order. A speech production task was used in which the subjects in each test trial had to utter one out of three or five response words as quickly as possible. In the so-called homogeneous condition these words were related in form, while in the heterogeneous condition they were unrelated in form. For monosyllabic response words shorter reaction times were obtained in the homogeneous than in the heterogeneous condition when the words had the same onset, but not when they had the same rhyme. Similarly, for disyllabic response words, the reaction times were shorter in the homogeneous than in the heterogeneous condition when the words shared only the onset of the first syllable, but not when they shared only its rhyme. Furthermore, a stronger facilitatory effect was observed when the words had the entire first syllable in common than when they only shared the onset, or the onset and the nucleus, but not the coda of the first syllable. These results suggest that syllables are phonologically encoded in two ordered steps, the first of which is dedicated to the onset and the second to the rhyme.
  • Meyer, A. S., & Bock, K. (1992). The tip-of-the-tongue phenomenon: Blocking or partial activation? Memory and Cognition, 20, 181-211.

    Abstract

    Tip-of-the-tongue states may represent the momentary unavailability of an otherwise accessible word or the weak activation of an otherwise inaccessible word. In three experiments designed to address these alternative views, subjects attempted to retrieve rare target words from their definitions. The definitions were followed by cues that were related to the targets in sound, by cues that were related in meaning, and by cues that were not related to the targets. Experiment 1 found that compared with unrelated cues, related cue words that were presented immediately after target definitions helped rather than hindered lexical retrieval, and that sound cues were more effective retrieval aids than meaning cues. Experiment 2 replicated these results when cues were presented after an initial target-retrieval attempt. These findings reverse a previous one (Jones, 1989) that was reproduced in Experiment 3 and shown to stem from a small group of unusually difficult target definitions.
  • Narasimhan, B. (2003). Motion events and the lexicon: The case of Hindi. Lingua, 113(2), 123-160. doi:10.1016/S0024-3841(02)00068-2.

    Abstract

    English, and a variety of Germanic languages, allow constructions such as the bottle floated into the cave , whereas languages such as Spanish, French, and Hindi are highly restricted in allowing manner of motion verbs to occur with path phrases. This typological observation has been accounted for in terms of the conflation of complex meaning in basic or derived verbs [Talmy, L., 1985. Lexicalization patterns: semantic structure in lexical forms. In: Shopen, T. (Ed.), Language Typology and Syntactic Description 3: Grammatical Categories and the Lexicon. Cambridge University Press, Cambridge, pp. 57–149; Levin, B., Rappaport-Hovav, M., 1995. Unaccusativity: At the Syntax–Lexical Semantics Interface. MIT Press, Cambridge, MA], or the presence of path “satellites” with special grammatical properties in the lexicon of languages such as English, which allow such phrasal combinations [cf. Talmy, L., 1985. Lexicalization patterns: semantic structure in lexical forms. In: Shopen, T. (Ed.), Language Typology and Syntactic Description 3: Grammatical Categories and the Lexicon. Cambridge University Press, Cambridge, pp. 57–149; Talmy, L., 1991. Path to realisation: via aspect and result. In: Proceedings of the Seventeenth Annual Meeting of the Berkeley Linguistics Society. Berkeley Linguistics Society, Berkeley, pp. 480–520]. I use data from Hindi to show that there is little empirical support for the claim that the constraint on the phrasal combination is correlated with differences in verb meaning or the presence of satellites in the lexicon of a language. However, proposals which eschew lexicalization accounts for more general aspectual constraints on the manner verb + path phrase combination in Spanish-type languages (Aske, J., 1989. Path Predicates in English and Spanish: A Closer look. In: Proceedings of the Fifteenth Annual Meeting of the Berkeley Linguistics Society. Berkeley Linguistics Society, Berkeley, pp. 1–14) cannot account for the full range of data in Hindi either. On the basis of these facts, I argue that an empirically adequate account can be formulated in terms of a general mapping constraint, formulated in terms of whether the lexical requirements of the verb strictly or weakly constrain its syntactic privileges of occurrence. In Hindi, path phrases can combine with manner of motion verbs only to the degree that they are compatible with the semantic profile of the verb. Path phrases in English, on the other hand, can extend the verb's “semantic profile” subject to certain constraints. I suggest that path phrases are licensed in English by the semantic requirements of the “construction” in which they appear rather than by the selectional requirements of the verb (Fillmore, C., Kay, P., O'Connor, M.C., 1988, Regularity and idiomaticity in grammatical constructions. Language 64, 501–538; Jackendoff, 1990, Semantic Structures. MIT Press, Cambridge, MA; Goldberg, 1995, Constructions: A Construction Grammar Approach to Argument Structure. University of Chicago Press, Chicago and London).
  • Norris, D., McQueen, J. M., & Cutler, A. (2003). Perceptual learning in speech. Cognitive Psychology, 47(2), 204-238. doi:10.1016/S0010-0285(03)00006-9.

    Abstract

    This study demonstrates that listeners use lexical knowledge in perceptual learning of speech sounds. Dutch listeners first made lexical decisions on Dutch words and nonwords. The final fricative of 20 critical words had been replaced by an ambiguous sound, between [f] and [s]. One group of listeners heard ambiguous [f]-final words (e.g., [WI tlo?], from witlof, chicory) and unambiguous [s]-final words (e.g., naaldbos, pine forest). Another group heard the reverse (e.g., ambiguous [na:ldbo?], unambiguous witlof). Listeners who had heard [?] in [f]-final words were subsequently more likely to categorize ambiguous sounds on an [f]–[s] continuum as [f] than those who heard [?] in [s]-final words. Control conditions ruled out alternative explanations based on selective adaptation and contrast. Lexical information can thus be used to train categorization of speech. This use of lexical information differs from the on-line lexical feedback embodied in interactive models of speech perception. In contrast to on-line feedback, lexical feedback for learning is of benefit to spoken word recognition (e.g., in adapting to a newly encountered dialect).
  • Norris, D., McQueen, J. M., Cutler, A., & Butterfield, S. (1997). The possible-word constraint in the segmentation of continuous speech. Cognitive Psychology, 34, 191-243. doi:10.1006/cogp.1997.0671.

    Abstract

    We propose that word recognition in continuous speech is subject to constraints on what may constitute a viable word of the language. This Possible-Word Constraint (PWC) reduces activation of candidate words if their recognition would imply word status for adjacent input which could not be a word - for instance, a single consonant. In two word-spotting experiments, listeners found it much harder to detectapple,for example, infapple(where [f] alone would be an impossible word), than invuffapple(wherevuffcould be a word of English). We demonstrate that the PWC can readily be implemented in a competition-based model of continuous speech recognition, as a constraint on the process of competition between candidate words; where a stretch of speech between a candidate word and a (known or likely) word boundary is not a possible word, activation of the candidate word is reduced. This implementation accurately simulates both the present results and data from a range of earlier studies of speech segmentation.
  • Nyberg, L., Marklund, P., Persson, J., Cabeza, R., Forkstam, C., Petersson, K. M., & Ingvar, M. (2003). Common prefrontal activations during working memory, episodic memory, and semantic memory. Neuropsychologia, 41(3), 371-377. doi:10.1016/S0028-3932(02)00168-9.

    Abstract

    Regions of the prefrontal cortex (PFC) are typically activated in many different cognitive functions. In most studies, the focus has been on the role of specific PFC regions in specific cognitive domains, but more recently similarities in PFC activations across cognitive domains have been stressed. Such similarities may suggest that a region mediates a common function across a variety of cognitive tasks. In this study, we compared the activation patterns associated with tests of working memory, semantic memory and episodic memory. The results converged on a general involvement of four regions across memory tests. These were located in left frontopolar cortex, left mid-ventrolateral PFC, left mid-dorsolateral PFC and dorsal anterior cingulate cortex. These findings provide evidence that some PFC regions are engaged during many different memory tests. The findings are discussed in relation to theories about the functional contribition of the PFC regions and the architecture of memory.
  • Nyberg, L., Sandblom, J., Jones, S., Stigsdotter Neely, A., Petersson, K. M., Ingvar, M., & Bäckman, L. (2003). Neural correlates of training-related memory improvement in adulthood and aging. Proceedings of the National Academy of Sciences of the United States of America, 100(23), 13728-13733. doi:10.1073/pnas.1735487100.

    Abstract

    Cognitive studies show that both younger and older adults can increase their memory performance after training in using a visuospatial mnemonic, although age-related memory deficits tend to be magnified rather than reduced after training. Little is known about the changes in functional brain activity that accompany training-induced memory enhancement, and whether age-related activity changes are associated with the size of training-related gains. Here, we demonstrate that younger adults show increased activity during memory encoding in occipito-parietal and frontal brain regions after learning the mnemonic. Older adults did not show increased frontal activity, and only those elderly persons who benefited from the mnemonic showed increased occipitoparietal activity. These findings suggest that age-related differences in cognitive reserve capacity may reflect both a frontal processing deficiency and a posterior production deficiency.
  • Ogdie, M. N., MacPhie, I. L., Minassian, S. L., Yang, M., Fisher, S. E., Francks, C., Cantor, R. M., McCracken, J. T., McGough, J. J., Nelson, S. F., Monaco, A. P., & Smalley, S. L. (2003). A genomewide scan for Attention-Deficit/Hyperactivity Disorder in an extended sample: Suggestive linkage on 17p11. American Journal of Human Genetics, 72(5), 1268-1279. doi:10.1086/375139.

    Abstract

    Attention-deficit/hyperactivity disorder (ADHD [MIM 143465]) is a common, highly heritable neurobehavioral disorder of childhood onset, characterized by hyperactivity, impulsivity, and/or inattention. As part of an ongoing study of the genetic etiology of ADHD, we have performed a genomewide linkage scan in 204 nuclear families comprising 853 individuals and 270 affected sibling pairs (ASPs). Previously, we reported genomewide linkage analysis of a “first wave” of these families composed of 126 ASPs. A follow-up investigation of one region on 16p yielded significant linkage in an extended sample. The current study extends the original sample of 126 ASPs to 270 ASPs and provides linkage analyses of the entire sample, using polymorphic microsatellite markers that define an ∼10-cM map across the genome. Maximum LOD score (MLS) analysis identified suggestive linkage for 17p11 (MLS=2.98) and four nominal regions with MLS values >1.0, including 5p13, 6q14, 11q25, and 20q13. These data, taken together with the fine mapping on 16p13, suggest two regions as highly likely to harbor risk genes for ADHD: 16p13 and 17p11. Interestingly, both regions, as well as 5p13, have been highlighted in genomewide scans for autism.
  • Otake, T., Yoneyama, K., Cutler, A., & van der Lugt, A. (1996). The representation of Japanese moraic nasals. Journal of the Acoustical Society of America, 100, 3831-3842. doi:10.1121/1.417239.

    Abstract

    Nasal consonants in syllabic coda position in Japanese assimilate to the place of articulation of a following consonant. The resulting forms may be perceived as different realizations of a single underlying unit, and indeed the kana orthographies represent them with a single character. In the present study, Japanese listeners' response time to detect nasal consonants was measured. Nasals in coda position, i.e., moraic nasals, were detected faster and more accurately than nonmoraic nasals, as reported in previous studies. The place of articulation with which moraic nasals were realized affected neither response time nor accuracy. Non-native subjects who knew no Japanese, given the same materials with the same instructions, simply failed to respond to moraic nasals which were realized bilabially. When the nasals were cross-spliced across place of articulation contexts the Japanese listeners still showed no significant place of articulation effects, although responses were faster and more accurate to unspliced than to cross-spliced nasals. When asked to detect the phoneme following the (cross-spliced) moraic nasal, Japanese listeners showed effects of mismatch between nasal and context, but non-native listeners did not. Together, these results suggest that Japanese listeners are capable of very rapid abstraction from phonetic realization to a unitary representation of moraic nasals; but they can also use the phonetic realization of a moraic nasal effectively to obtain anticipatory information about following phonemes.
  • Ozyurek, A. (1996). How children talk about a conversation. Journal of Child Language, 23(3), 693-714. doi:10.1017/S0305000900009004.

    Abstract

    This study investigates how children of different ages talk about a conversation that they have witnessed. 48 Turkish children, five, nine and thirteen years in age, saw a televised dialogue between two Sesame Street characters (Bert and Ernie). Afterward, they narrated what they had seen and heard. Their reports were analysed for the development of linguistic devices used to orient their listeners to the relevant properties of a conversational exchange. Each utterance in the child's narrative was analysed as to its conversational role: (1) whether the child used direct or indirect quotation frames; (2) whether the child marked the boundaries of conversational turns using speakers' names and (3) whether the child used a marker for pairing of utterances made by different speakers (agreement-disagreement, request-refusal, questioning-answering). Within pairings, children's use of (a) the temporal and evaluative connectivity markers and (b) the kind of verb of saying were identified. The data indicate that there is a developmental change in children's ability to use appropriate linguistic means to orient their listeners to the different properties of a conversation. The development and use of these linguistic means enable the child to establish different social roles in a narrative interaction. The findings are interpreted in terms of the child's social-communicative development from being a ' character' to becoming a ' narrator' and ' author' of the reported conversation in the narrative situation.
  • Ozyurek, A., & Trabasso, T. (1997). Evaluation during the understanding of narratives. Discourse Processes, 23(3), 305-337. Retrieved from http://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=12673020&site=ehost-live.

    Abstract

    Evaluation plays a role in the telling and understanding of narratives, in communicative interaction, emotional understanding, and in psychological well-being. This article reports a study of evaluation by describing how readers monitor the concerns of characters over the course of a narrative. The main hypothesis is that readers tract the well-being via the expression of a character's internal states. Reader evaluations were revealed in think aloud protocols obtained during reading of narrative texts, one sentence at a time. Five kinds of evaluative inferences were found: appraisals (good versus bad), preferences (like versus don't like), emotions (happy versus frustrated), goals (want versus don't want), or purposes (to attain or maintain X versus to prevent or avoid X). Readers evaluated all sentences. The mean rate of evaluation per sentence was 0.55. Positive and negative evaluations over the course of the story indicated that things initially went badly for characters, improved with the formulation and execution of goal plans, declined with goal failure, and improved as characters formulated new goals and succeeded. The kind of evaluation made depended upon the episodic category of the event and the event's temporal location in the story. Evaluations also served to explain or predict events. In making evaluations, readers stayed within the frame of the story and perspectives of the character or narrator. They also moved out of the narrative frame and addressed evaluations towards the experimenter in a communicative context.
  • Paterson, K. B., Liversedge, S. P., Rowland, C. F., & Filik, R. (2003). Children's comprehension of sentences with focus particles. Cognition, 89(3), 263-294. doi:10.1016/S0010-0277(03)00126-4.

    Abstract

    We report three studies investigating children's and adults' comprehension of sentences containing the focus particle only. In Experiments 1 and 2, four groups of participants (6–7 years, 8–10 years, 11–12 years and adult) compared sentences with only in different syntactic positions against pictures that matched or mismatched events described by the sentence. Contrary to previous findings (Crain, S., Ni, W., & Conway, L. (1994). Learning, parsing and modularity. In C. Clifton, L. Frazier, & K. Rayner (Eds.), Perspectives on sentence processing. Hillsdale, NJ: Lawrence Erlbaum; Philip, W., & Lynch, E. (1999). Felicity, relevance, and acquisition of the grammar of every and only. In S. C. Howell, S. A. Fish, & T. Keith-Lucas (Eds.), Proceedings of the 24th annual Boston University conference on language development. Somerville, MA: Cascadilla Press) we found that young children predominantly made errors by failing to process contrast information rather than errors in which they failed to use syntactic information to restrict the scope of the particle. Experiment 3 replicated these findings with pre-schoolers.
  • Perdue, C., & Klein, W. (1992). Why does the production of some learners not grammaticalize? Studies in Second Language Acquisition, 14, 259-272. doi:10.1017/S0272263100011116.

    Abstract

    In this paper we follow two beginning learners of English, Andrea and Santo, over a period of 2 years as they develop means to structure the declarative utterances they produce in various production tasks, and then we look at the following problem: In the early stages of acquisition, both learners develop a common learner variety; during these stages, we see a picture of two learner varieties developing similar regularities determined by the minimal requirements of the tasks we examine. Andrea subsequently develops further morphosyntactic means to achieve greater cohesion in his discourse. But Santo does not. Although we can identify contexts where the grammaticalization of Andrea's production allows him to go beyond the initial constraints of his variety, it is much more difficult to ascertain why Santo, faced with the same constraints in the same contexts, does not follow this path. Some lines of investigation into this problem are then suggested.
  • Petersson, K. M., Elfgren, C., & Ingvar, M. (1997). A dynamic role of the medial temporal lobe during retrieval of declarative memory in man. NeuroImage, 6, 1-11.

    Abstract

    Understanding the role of the medial temporal lobe (MTL) in learning and memory is an important problem in cognitive neuroscience. Memory and learning processes that depend on the function of the MTL and related diencephalic structures (e.g., the anterior and mediodorsal thalamic nuclei) are defined as declarative. We have studied the MTL activity as indicated by regional cerebral blood flow with positron emission tomography and statistical parametric mapping during recall of abstract designs in a less practiced memory state as well as in a well-practiced (well-encoded) memory state. The results showed an increased activity of the MTL bilaterally (including parahippocampal gyrus extending into hippocampus proper, as well as anterior lingual and anterior fusiform gyri) during retrieval in the less practiced memory state compared to the well-practiced memory state, indicating a dynamic role of the MTL in retrieval during the learning processes. The results also showed that the activation of the MTL decreases as the subjects learn to draw abstract designs from memory, indicating a changing role of the MTL during recall in the earlier stages of acquisition compared to the well-encoded declarative memory state.
  • Petersson, K. M., Sandblom, J., Elfgren, C., & Ingvar, M. (2003). Instruction-specific brain activations during episodic encoding: A generalized level of processing effect. Neuroimage, 20, 1795-1810. doi:10.1016/S1053-8119(03)00414-2.

    Abstract

    In a within-subject design we investigated the levels-of-processing (LOP) effect using visual material in a behavioral and a corresponding PET study. In the behavioral study we characterize a generalized LOP effect, using pleasantness and graphical quality judgments in the encoding situation, with two types of visual material, figurative and nonfigurative line drawings. In the PET study we investigate the related pattern of brain activations along these two dimensions. The behavioral results indicate that instruction and material contribute independently to the level of recognition performance. Therefore the LOP effect appears to stem both from the relative relevance of the stimuli (encoding opportunity) and an altered processing of stimuli brought about by the explicit instruction (encoding mode). In the PET study, encoding of visual material under the pleasantness (deep) instruction yielded left lateralized frontoparietal and anterior temporal activations while surface-based perceptually oriented processing (shallow instruction) yielded right lateralized frontoparietal, posterior temporal, and occipitotemporal activations. The result that deep encoding was related to the left prefrontal cortex while shallow encoding was related to the right prefrontal cortex, holding the material constant, is not consistent with the HERA model. In addition, we suggest that the anterior medial superior frontal region is related to aspects of self-referential semantic processing and that the inferior parts of the anterior cingulate as well as the medial orbitofrontal cortex is related to affective processing, in this case pleasantness evaluation of the stimuli regardless of explicit semantic content. Finally, the left medial temporal lobe appears more actively engaged by elaborate meaning-based processing and the complex response pattern observed in different subregions of the MTL lends support to the suggestion that this region is functionally segregated.
  • Pijls, F., & Kempen, G. (1986). Een psycholinguïstisch model voor grammatische samentrekking. De Nieuwe Taalgids, 79, 217-234.
  • Pine, J. M., Lieven, E. V., & Rowland, C. F. (1996). Observational and checklist measures of vocabulary composition: What do they mean? Journal of Child Language, 23(3), 573-590. doi:10.1017/S0305000900008953.

    Abstract

    Observational and checklist measures of vocabulary composition have both recently been used to look at the absolute proportion of nouns in children's early vocabularies. However, they have tended to generate rather different results. The present study is an attempt to investigate the relationship between such measures in a sample of 26 children between 1;1 and 2;1 at approximately 50 and 100 words. The results show that although observational and checklist measures are significantly correlated, there are also systematic quantitative differences between them which seem to reflect a combination of checklist, maternal-report and observational sampling biases. This suggests that, although both kinds of measure may represent good indices of differences in vocabulary size and composition across children and hence be useful as dependent variables in correlational research, neither may be ideal for estimating the absolute proportion of nouns in children's vocabularies. The implication is that questions which rely on information about the absolute proportion of particular kinds of words in children's vocabularies can only be properly addressed by detailed longitudinal studies in which an attempt is made to collect more comprehensive vocabulary records for individual children.
  • Pine, J. M., Lieven, E. V., & Rowland, C. F. (1997). Stylistic variation at the “single-word” stage: Relations between maternal speech characteristics and children's vocabulary composition and usage. Child Development, 68(5), 807-819. doi:10.1111/j.1467-8624.1997.tb01963.x.

    Abstract

    In this study we test a number of different claims about the nature of stylistic variation at the “single-word” stage by examining the relation between variation in early vocabulary composition, variation in early language use, and variation in the structural and functional propreties of mothers' child-directed speech. Maternal-report and observational data were collected for 26 children at 10, 50, and 100 words, These were then correlated with a variety of different measures of maternal speech at 10 words, The results show substantial variation in the percentage of common nouns and unanalyzed phrases in children's vocabularies, and singficant relations between this variation and the way in which language is used by the child. They also reveal singficant relations between the way in whch mothers use language at 10 words and the way in chich their children use language at 50 words and between certain formal properties of mothers speech at 10 words and the percentage of common nouns and unanalyzed phrases in children's early vocabularies, However, most of these relations desappear when an attempt is made to control for ossible effects of the child on the mother at Time 1. The exception is a singficant negative correlation between mothers tendency to produce speech that illustrates word boundaries and the percentage of unanalyzed phrases at 50 and 100 words. This suggests that mothers whose sprech provides the child with information about where new words begin and end tend to have children with few unanalyzed. phrases in their early vocabularies.
  • Poletiek, F. H. (1997). De wet 'bijzondere opnemingen in psychiatrische ziekenhuizen' aan de cijfers getoetst. Maandblad voor Geestelijke Volksgezondheid, 4, 349-361.
  • Poletiek, F. H. (in preparation). Inside the juror: The psychology of juror decision-making [Bespreking van De geest van de jury (1997)].
  • Poletiek, F. H. (1996). Paradoxes of falsification. Quarterly Journal of Experimental Psychology Section A: Human Experimental Psychology, 49(2), 447-462. doi:10.1080/713755628.
  • Praamstra, P., Meyer, A. S., Cools, A. R., Horstink, M. W. I. M., & Stegeman, D. F. (1996). Movement preparation in Parkinson's disease: Time course and distribution of movement-related potentials in a movement precueing task. Brain, 119, 1689-1704. doi:10.1093/brain/119.5.1689.

    Abstract

    Investigations of the effects of advance information on movement preparation in Parkinson's disease using reaction time (RT) measures have yielded contradictory results. In order to obtain direct information regarding the time course of movement preparation, we combined RT measurements in a movement precueing task with multi-channel recordings of movement-related potentials in the present study. Movements of the index and middle fingers of the left and right hand were either precued or not by advance information regarding the side (left or right hand) of the required response. Reaction times were slower for patients than for control subjects. Both groups benefited equally from informative precues, indicating that patients utilized the advance information as effectively as control subjects. Lateralization of the movement-preceding cerebral activity [i.e. the lateralized readiness potential (LRP)] confirmed that patients used the available partial information to prepare their responses and started this process no later than controls. In conjunction with EMG onset times, the LRP onset measures allowed for a fractionation of the RTs, which provided clues to the stages where the slowness of Parkinson's disease patients might arise. No definite abnormalities of temporal parameters were found, but differences in the distribution of the lateralized movement-preceding activity between patients and controls suggested differences in the cortical organization of movement preparation. Differences in amplitude of the contingent negative variation (CNV) and differences in the way in which the CNV was modulated by the information given by the precue pointed in the same direction. A difference in amplitude of the P300 between patients and controls suggested that preprogramming a response required more effort from. patients than from control subjects.
  • Praamstra, P., Hagoort, P., Maassen, B., & Crul, T. (1991). Word deafness and auditory cortical function: A case history and hypothesis. Brain, 114, 1197-1225. doi:10.1093/brain/114.3.1197.

    Abstract

    A patient who already had Wernick's aphasia due to a left temporal lobe lesion suffered a severe deterioration specifically of auditory language comprehension, subsequent to right temporal lobe infarction. A detailed comparison of his new condition with his language status before the second stroke revealed that the newly acquired deficit was limited to tasks related to auditory input. Further investigations demonstrated a speech perceptual disorder, which we analysed as due to deficits both at the level of general auditory processes and at the level of phonetic analysis. We discuss some arguments related to hemisphere specialization of phonetic processing and to the disconnection explanation of word deafness that support the hypothesis of word deafness being generally caused by mixed deficits.
  • Radeau, M., & Van Berkum, J. J. A. (1996). Gender decision. Language and Cognitive Processes, 11(6), 605-610. doi:10.1080/016909696387006.

    Abstract

    In languages in which nouns have a grammatical gender, word recognition can be estimated by gender decision response times. Although gender decision has yet to be used extensively, it has proved sensitive to several factors that have been shown to affect lexical access. The task is not restricted to spoken language but can be used with linguistic information from other sensory modalities.

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