Publications

Abstract

It is the purpose of the present paper to highlight the figure of Eubulides, a relatively unknown Greek philosopher who lived ±405–330 BC and taught at Megara, not far from Athens. He is mainly known for his four paradoxes (the Liar, the Sorites, the Electra, and the Horns), and for the mutual animosity between him and his younger contemporary Aristotle. The Megarian school of philosophy was one of the main sources of the great Stoic tradition in ancient philosophy. What has never been made explicit in the literature is the importance of the four paradoxes for the study of meaning in natural language: they summarize the whole research programme of 20th century formal or formally oriented semantics, including the problems of vague predicates (Sorites), intensional contexts (Electra), and presuppositions (Horns). One might say that modern formal or formally oriented semantics is essentially an attempt at finding linguistically tenable answers to problems arising in the context of Aristotelian thought. It is a surprising and highly significant fact that a contemporary of Aristotle already spotted the main weaknesses of the Aristotelian paradigm.

Abstract

This paper is an attempt to show that given the available observations on the behaviour of negation and presuppositions there is no simpler explanation than to assume that natural language has two distinct negation operators, the minimal negation which preserves presuppositions and the radical negation which does not. The three-valued logic emerging from this distinction, and especially its model-theory, are discussed in detail. It is, however, stressed that the logic itself is only epiphenomenal on the structures and processes involved in the interpretation of sentences. Horn (1985) brings new observations to bear, related with metalinguistic uses of negation, and proposes a “pragmatic” ambiguity in negation to the effect that in descriptive (or “straight”) use negation is the classical bivalent operator, whereas in metalinguistic use it is non-truthfunctional but only pragmatic. Van der Sandt (to appear) accepts Horn's observations but proposes a different solution: he proposes an ambiguity in the argument clause of the negation operator (which, for him, too, is classical and bivalent), according to whether the negation takes only the strictly asserted proposition or covers also the presuppositions, the (scalar) implicatures and other implications (in particular of style and register) of the sentence expressing that proposition. These theories are discussed at some length. The three-valued analysis is defended on the basis of partly new observations, which do not seem to fit either Horn's or Van der Sandt's solution. It is then placed in the context of incremental discourse semantics, where both negations are seen to do the job of keeping increments out of the discourse domain, though each does so in its own specific way. The metalinguistic character of the radical negation is accounted for in terms of the incremental apparatus. The metalinguistic use of negation in denials of implicatures or implications of style and register is regarded as a particular form of minimal negation, where the negation denies not the proposition itself but the appropriateness of the use of an expression in it. This appropriateness negation is truth-functional and not pragmatic, but it applies to a particular, independently motivated, analysis of the argument clause. The ambiguity of negation in natural language is different from the ordinary type of ambiguity found in the lexicon. Normally, lexical ambiguities are idiosyncratic, highly contingent, and unpredictable from language to language. In the case of negation, however, the two meanings are closely related, both truth-conditionally and incrementally. Moreover, the mechanism of discourse incrementation automatically selects the right meaning. These properties are taken to provide a sufficient basis for discarding the, otherwise valid, objection that negation is unlikely to be ambiguous because no known language makes a lexical distinction between the two readings.

Abstract

Dissociations in the ability to produce words of different grammatical categories are well established in neuropsychology but have not been corroborated fully with evidence from brain imaging. Here we report on a PET study designed to reveal the anatomical correlates of grammatical processes involving nouns and verbs. German-speaking subjects were asked to produce either plural and singular nouns, or first-person plural and singular verbs. Verbs, relative to nouns, activated a left frontal cortical network, while the opposite contrast (nouns–verbs) showed greater activation in temporal regions bilaterally. Similar patterns emerged when subjects performed the task with pseudowords used as nouns or as verbs. These results converge with findings from lesion studies and suggest that grammatical category is an important dimension of organization for knowledge of language in the brain.

Abstract

Positron emission tomography was used to investigate two competing hypotheses about the role of the left inferior frontal gyrus (IFG) in word generation. One proposes a domain-specific organization, with neural activation dependent on the type of information being processed, i.e., surface sound structure or semantic. The other proposes a process-specific organization, with activation dependent on processing demands, such as the amount of selection needed to decide between competing lexical alternatives. In a novel word retrieval task, word reconstruction (WR), subjects generated real words from heard non-words by the substitution of either a vowel or consonant. Both types of lexical retrieval, informed by sound structure alone, produced activation within anterior and posterior left IFG regions. Within these regions there was greater activity for consonant WR, which is more difficult and imposes greater processing demands. These results support a process-specific organization of the anterior left IFG.

Abstract

Accumulating evidence suggests that spoken word production requires different amounts of top-down control depending on the prevailing circumstances. For example, during Stroop-like tasks, the interference in response time (RT) is typically larger following congruent trials than following incongruent trials. This effect is called the Gratton effect, and has been taken to reflect top-down control adjustments based on the previous trial type. Such control adjustments have been studied extensively in Stroop and Eriksen flanker tasks (mostly using manual responses), but not in the picture-word interference (PWI) task, which is a workhorse of language production research. In one of the few studies of the Gratton effect in PWI, Van Maanen and Van Rijn (2010) examined the effect in picture naming RTs during dual-task performance. Based on PWI effect differences between dual-task conditions, they argued that the functional locus of the PWI effect differs between post-congruent trials (i.e., locus in perceptual and conceptual encoding) and post-incongruent trials (i.e., locus in word planning). However, the dual-task procedure may have contaminated the results. We therefore performed an EEG study on the Gratton effect in a regular PWI task. We observed a PWI effect in the RTs, in the N400 component of the event-related brain potentials, and in the midfrontal theta power, regardless of the previous trial type. Moreover, the RTs, N400, and theta power reflected the Gratton effect. These results provide evidence that the PWI effect arises at the word planning stage following both congruent and incongruent trials, while the amount of top-down control changes depending on the previous trial type.

Abstract

Accumulating evidence suggests that spoken word production requires different amounts of top-down control depending on the prevailing circumstances. For example, during Stroop-like tasks, the interference in response time (RT) is typically larger following congruent trials than following incongruent trials. This effect is called the Gratton effect, and has been taken to reflect top-down control adjustments based on the previous trial type. Such control adjustments have been studied extensively in Stroop and Eriksen flanker tasks (mostly using manual responses), but not in the picture–word interference (PWI) task, which is a workhorse of language production research. In one of the few studies of the Gratton effect in PWI, Van Maanen and Van Rijn (2010) examined the effect in picture naming RTs during dual-task performance. Based on PWI effect differences between dual-task conditions, they argued that the functional locus of the PWI effect differs between post-congruent trials (i.e., locus in perceptual and conceptual encoding) and post-incongruent trials (i.e., locus in word planning). However, the dual-task procedure may have contaminated the results. We therefore performed an electroencephalography (EEG) study on the Gratton effect in a regular PWI task. We observed a PWI effect in the RTs, in the N400 component of the event-related brain potentials, and in the midfrontal theta power, regardless of the previous trial type. Moreover, the RTs, N400, and theta power reflected the Gratton effect. These results provide evidence that the PWI effect arises at the word planning stage following both congruent and incongruent trials, while the amount of top-down control changes depending on the previous trial type.

Abstract

Allocation and use of central processing capacity have been associated with the P3 event-related brain potential amplitude in a large variety of non-linguistic tasks. However, little is known about the P3 in spoken language production. Moreover, the few studies that are available report opposing P3 effects when task complexity is manipulated. We investigated allocation and use of central processing capacity in a spoken phrase production task: Participants switched every second trial between describing pictures using noun phrases with one adjective (size only; simple condition, e.g., “the big desk”) or two adjectives (size and color; complex condition, e.g., “the big red desk”). Capacity allocation was manipulated by complexity, and capacity use by switching. Response time (RT) was longer for complex than for simple trials. Moreover, complexity and switching interacted: RTs were longer on switch than on repeat trials for simple phrases but shorter on switch than on repeat trials for complex phrases. P3 amplitude increased with complexity. Moreover, complexity and switching interacted: The complexity effect was larger on the switch trials than on the repeat trials. These results provide evidence that the allocation and use of central processing capacity in language production are differentially reflected in the P3 amplitude.

Abstract

Artificial grammar learning (AGL) has been probed with forced-choice behavioral tests (active tests). Recent attempts to probe the outcomes of learning (implicitly acquired knowledge) with eye-movement responses (passive tests) have shown null results. However, these latter studies have not tested for sensitivity effects, for example, increased eye movements on a printed violation. In this study, we tested for sensitivity effects in AGL tests with (Experiment 1) and without (Experiment 2) concurrent active tests (preference- and grammaticality classification) in an eye-tracking experiment. Eye movements discriminated between sequence types in passive tests and more so in active tests. The eye-movement profile did not differ between preference and grammaticality classification, and it resembled sensitivity effects commonly observed in natural syntax processing. Our findings show that the outcomes of implicit structured sequence learning can be characterized in eye tracking. More specifically, whole trial measures (dwell time, number of fixations) showed robust AGL effects, whereas first-pass measures (first-fixation duration) did not. Furthermore, our findings strengthen the link between artificial and natural syntax processing, and they shed light on the factors that determine performance differences in preference and grammaticality classification tests

Abstract

How can we grasp the temporal structure of events? A few studies have indicated that representations of temporal structure are acquired when there is an intention to learn, but not when learning is incidental. Response-to-stimulus intervals, uncorrelated temporal structures, unpredictable ordinal information, and lack of metrical organization have been pointed out as key obstacles to incidental temporal learning, but the literature includes piecemeal demonstrations of learning under all these circumstances. We suggest that the unacknowledged effects of ordinal load may help reconcile these conflicting findings, ordinal load referring to the cost of identifying the sequence of events (e.g., tones, locations) where a temporal pattern is embedded. In a first experiment, we manipulated ordinal load into simple and complex levels. Participants learned ordinal-simple sequences, despite their uncorrelated temporal structure and lack of metrical organization. They did not learn ordinal-complex sequences, even though there were no response-to-stimulus intervals nor unpredictable ordinal information. In a second experiment, we probed learning of ordinal-complex sequences with strong metrical organization, and again there was no learning. We conclude that ordinal load is a key obstacle to incidental temporal learning. Further analyses showed that the effect of ordinal load is to mask the expression of temporal knowledge, rather than to prevent learning.

Abstract

The suitability of the Artificial Grammar Learning (AGL) paradigm to capture relevant aspects of the acquisition of linguistic structures has been empirically tested in a number of EEG studies. Some have shown a syntax-related P600 component, but it has not been ruled out that the AGL P600 effect is a response to surface features (e.g., subsequence familiarity) rather than the underlying syntax structure. Therefore, in this study, we controlled for the surface characteristics of the test sequences (associative chunk strength) and recorded the EEG before (baseline preference classification) and
after (preference and grammaticality classification) exposure to a grammar. A typical, centroparietal P600 effect was elicited by grammatical violations after exposure, suggesting that the AGL P600 effect signals a response to structural irregularities. Moreover, preference and grammaticality classification showed a qualitatively similar ERP profile, strengthening the idea that the implicit structural mere
exposure paradigm in combination with preference classification is a suitable alternative to the traditional grammaticality classification test.

Abstract

Aims and objectives: The aim was to identify which criteria children use to decide on the category membership of native and non-native vowels, and to get insight into the organization of phonological representations in the bilingual mind. Methodology: The study consisted of two cross-language mispronunciation detection tasks in which L2 vowels were inserted into L1 words and vice versa. In Experiment 1, 10- to 12-year-old Dutch-speaking children were presented with Dutch words which were either pronounced with the target Dutch vowel or with an English vowel inserted in the Dutch consonantal frame. Experiment 2 was a mirror of the first, with English words which were pronounced “correctly” or which were “mispronounced” with a Dutch vowel. Data and analysis: Analyses focused on extent to which child and adult listeners accepted substitutions of Dutch vowels by English ones, and vice versa. Findings: The results of Experiment 1 revealed that between the age of ten and twelve children have well-established phonological vowel categories in their native language. However, Experiment 2 showed that in their non-native language, children tended to accept mispronounced items which involve sounds from their native language. At the same time, though, they did not fully rely on their native phonemic inventory because the children accepted most of the correctly pronounced English items. Originality: While many studies have examined native and non-native perception by infants and adults, studies on first and second language perception of school-age children are rare. This study adds to the body of literature aimed at expanding our knowledge in this area. Implications: The study has implications for models of the organization of the bilingual mind: while proficient adult non-native listeners generally have clearly separated sets of phonological representations for their two languages, for non-proficient child learners the L1 phonology still exerts a strong influence on the L2 phonology.

Abstract

Learning to read is known to result in a reorganization of the developing cerebral cortex. In this longitudinal resting-state functional magnetic resonance imaging study in illiterate adults we show that only 6 months of literacy training can lead to neuroplastic changes in the mature brain. We observed that literacy-induced neuroplasticity is not confined to the cortex but increases the functional connectivity between the occipital lobe and subcortical areas in the midbrain and
the thalamus. Individual rates of connectivity increase were significantly related to the individualdecoding skill gains. These findings crucially complement current neurobiological concepts ofnormal and impaired literacy acquisition.

Abstract

In this paper we explore the results of a large-scale online game called ‘the Great Language Game’, in which people listen to an audio speech sample and make a forced-choice guess about the identity of the language from 2 or more alternatives. The data include 15 million guesses from 400 audio recordings of 78 languages. We investigate which languages are confused for which in the game, and if this correlates with the similarities that linguists identify between languages. This includes shared lexical items, similar sound inventories and established historical relationships. Our findings are, as expected, that players are more likely to confuse two languages that are objectively more similar. We also investigate factors that may affect players’ ability to accurately select the target language, such as how many people speak the language, how often the language is mentioned in written materials and the economic power of the target language community. We see that non-linguistic factors affect players’ ability to accurately identify the target. For example, languages with wider ‘global reach’ are more often identified correctly. This suggests that both linguistic and cultural knowledge influence the perception and recognition of languages and their similarity.

Abstract

This study investigates whether there is a universal tendency for content
interrogative words (wh-­words) within a language to sound similar in order to facilitate
pragmatic inference in conversation. Gaps between turns in conversation are very
short, meaning that listeners must begin planning their turn as soon as possible.
While previous research has shown that paralinguistic features such as prosody and
eye gaze provide cues to the pragmatic function of upcoming turns, we hypothesise
that a systematic phonetic cue that marks interrogative words would also help early
recognition of questions (allowing early preparation of answers), for instance wh-­
words sounding similar within a language. We analyzed 226 languages from 66
different language families by means of permutation tests. We found that initial
segments of wh-­words were more similar within a language than between languages,
also when controlling for language family, geographic area (stratified permutation)
and analyzability (compound phrases excluded). Random samples tests revealed that
initial segments of wh-­words were more similar than initial segments of randomly
selected word sets and conceptually related word sets (e.g., body parts, actions,
pronouns). Finally, we hypothesized that this cue would be more useful at the
beginning of a turn, so the similarity of the initial segment of wh-­words should be
greater in languages that place them at the beginning of a clause. We gathered
typological data on 110 languages, and found the predicted trend, although statistical
significance was not attained. While there may be several mechanisms that bring
about this pattern (e.g., common derivation), we suggest that the ultimate explanation
of the similarity of interrogative words is to facilitate early speech-­act recognition.
Importantly, this hypothesis can be tested empirically, and the current results provide
a sound basis for future experimental tests.

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed behavioral disorder in childhood and likely represents an extreme of normal behavior. ADHD significantly impacts learning in school-age children and leads to impaired functioning throughout the life span. There is strong evidence for a genetic etiology of the disorder, although putative alleles, principally in dopamine-related pathways suggested by candidate-gene studies, have very small effect sizes. We use affected-sib-pair analysis in 203 families to localize the first major susceptibility locus for ADHD to a 12-cM region on chromosome 16p13 (maximum LOD score 4.2; P=.000005), building upon an earlier genomewide scan of this disorder. The region overlaps that highlighted in three genome scans for autism, a disorder in which inattention and hyperactivity are common, and physically maps to a 7-Mb region on 16p13. These findings suggest that variations in a gene on 16p13 may contribute to common deficits found in both ADHD and autism.

Abstract

Ambiguity in natural language is ubiquitous, yet spoken communication is effective due to integration of information carried in the speech signal with information available in the surrounding multimodal landscape. Language mediated visual attention requires visual and linguistic information integration and has thus been used to examine properties of the architecture supporting multimodal processing during spoken language comprehension. In this paper we test predictions generated by alternative models of this multimodal system. A model (TRACE) in which multimodal information is combined at the point of the lexical representations of words generated predictions of a stronger effect of phonological rhyme relative to semantic and visual information on gaze behaviour, whereas a model in which sub-lexical information can interact across modalities (MIM) predicted a greater influence of visual and semantic information, compared to phonological rhyme. Two visual world experiments designed to test these predictions offer support for sub-lexical multimodal interaction during online language processing.

Abstract

A quantitative model of human categorization behavior is proposed, which can be applied to 4-alternative forced-choice categorization data involving two binary classifications. A number of processing dependencies between the two classifications are explicitly formulated, such as the dependence of the location, orientation, and steepness of the class boundary for one classification on the outcome of the other classification. The significance of various types of dependencies can be tested statistically. Analyses of a data set from the literature shows that interesting dependencies in human speech recognition can be uncovered using the model.

Abstract

The closely related paralogues FOXP2 and FOXP1 encode transcription factors with shared functions in the development of many tissues, including the brain. However, while mutations in FOXP2 lead to a speech/language disorder characterized by childhood apraxia of speech (CAS), the clinical profile of FOXP1 variants includes a broader neurodevelopmental phenotype with global developmental delay, intellectual disability and speech/language impairment. Using clinical whole-exome sequencing, we report an identical de novo missense FOXP1 variant identified in three unrelated patients. The variant, p.R514H, is located in the forkhead-box DNA-binding domain and is equivalent to the well-studied p.R553H FOXP2 variant that co-segregates with CAS in a large UK family. We present here for the first time a direct comparison of the molecular and clinical consequences of the same mutation affecting the equivalent residue in FOXP1 and FOXP2. Detailed functional characterization of the two variants in cell model systems revealed very similar molecular consequences, including aberrant subcellular localization, disruption of transcription factor activity and deleterious effects on protein interactions. Nonetheless, clinical manifestations were broader and more severe in the three cases carrying the p.R514H FOXP1 variant than in individuals with the p.R553H variant related to CAS, highlighting divergent roles of FOXP2 and FOXP1 in neurodevelopment.

Abstract

Women are known to have stronger prosocial preferences than men, but it remains an open question as to how these behavioural differences arise from differences in brain functioning. Here, we provide a neurobiological account for the hypothesized gender difference. In a pharmacological study and an independent neuroimaging study, we tested the hypothesis that the neural reward system encodes the value of sharing money with others more strongly in women than in men. In the pharmacological study, we reduced receptor type-specific actions of dopamine, a neurotransmitter related to reward processing, which resulted in more selfish decisions in women and more prosocial decisions in men. Converging findings from an independent neuroimaging study revealed gender-related activity in neural reward circuits during prosocial decisions. Thus, the neural reward system appears to be more sensitive to prosocial rewards in women than in men, providing a neurobiological account for why women often behave more prosocially than men.

A large body of evidence suggests that women are often more prosocial (for example, generous, altruistic and inequality averse) than men, at least when other factors such as reputation and strategic considerations are excluded1,2,3. This dissociation could result from cultural expectations and gender stereotypes, because in Western societies women are more strongly expected to be prosocial4,5,6 and sensitive to variations in social context than men1. It remains an open question, however, whether and how on a neurobiological level the social preferences of women and men arise from differences in brain functioning. The assumption of gender differences in social preferences predicts that the neural reward system’s sensitivity to prosocial and selfish rewards should differ between women and men. Specifically, the hypothesis would be that the neural reward system is more sensitive to prosocial than selfish rewards in women and more sensitive to selfish than prosocial rewards in men. The goal of the current study was to test in two independent experiments for the hypothesized gender differences on both a pharmacological and a haemodynamic level. In particular, we examined the functions of the neurotransmitter dopamine using a dopamine receptor antagonist, and the role of the striatum (a brain region strongly innervated by dopamine neurons) during social decision-making in women and men using neuroimaging.

The neurotransmitter dopamine is thought to play a key role in neural reward processing7,8. Recent evidence suggests that dopaminergic activity is sensitive not only to rewards for oneself but to rewards for others as well9. The assumption that dopamine is sensitive to both self- and other-related outcomes is consistent with the finding that the striatum shows activation for both selfish and shared rewards10,11,12,13,14,15. The dopaminergic response may represent a net signal encoding the difference between the value of preferred and unpreferred rewards8. Regarding the hypothesized gender differences in social preferences, this account makes the following predictions. If women prefer shared (prosocial) outcomes2, women’s dopaminergic signals to shared rewards will be stronger than to non-shared (selfish) rewards, so reducing dopaminergic activity should bias women to make more selfish decisions. In line with this hypothesis, a functional imaging study reported enhanced striatal activation in female participants during charitable donations11. In contrast, if men prefer selfish over prosocial rewards, dopaminergic activity should be enhanced to selfish compared to prosocial rewards. In line with this view, upregulating dopaminergic activity in a sample of exclusively male participants increased selfish behaviour in a bargaining game16. Thus, contrary to the hypothesized effect in women, reducing dopaminergic neurotransmission should render men more prosocial. Taken together, the current study tested the following three predictions: we expected the dopaminergic reward system (1) to be more sensitive to prosocial than selfish rewards in women and (2) to be more sensitive to selfish than prosocial rewards in men. As a consequence of these two predictions, we also predicted (3) dopaminoceptive regions such as the striatum to show stronger activation to prosocial relative to selfish rewards in women than in men.

To test these predictions, we conducted a pharmacological study in which we reduced dopaminergic neurotransmission with amisulpride. Amisulpride is a dopamine antagonist that is highly specific for dopaminergic D2/D3 receptors17. After receiving amisulpride or placebo, participants performed an interpersonal decision task18,19,20, in which they made choices between a monetary reward only for themselves (selfish reward option) and sharing money with others (prosocial reward option). We expected that blocking dopaminergic neurotransmission with amisulpride, relative to placebo, would result in fewer prosocial choices in women and more prosocial choices in men. To investigate whether potential gender-related effects of dopamine are selective for social decision-making, we also tested the effects of amisulpride on time preferences in a non-social control task that was matched to the interpersonal decision task in terms of choice structure.

In addition, because dopaminergic neurotransmission plays a crucial role in brain regions involved in value processing, such as the striatum21, a gender-related role of dopaminergic activity for social decision-making should also be reflected by dissociable activity patterns in the striatum. Therefore, to further test our hypothesis, we investigated the neural correlates of social decision-making in a functional imaging study. In line with our predictions for the pharmacological study, we expected to find stronger striatum activity during prosocial relative to selfish decisions in women, whereas men should show enhanced activity in the striatum for selfish relative to prosocial choices.

Abstract

Perceptual information is important for the meaning of nouns. We present modality exclusivity norms for 485 Dutch nouns rated on visual, auditory, haptic, gustatory, and olfactory associations. We found these nouns are highly multimodal. They were rated most dominant in vision, and least in olfaction. A factor analysis identified two main dimensions: one loaded strongly on olfaction and gustation (reflecting joint involvement in flavor), and a second loaded strongly on vision and touch (reflecting joint involvement in manipulable objects). In a second study, we validated the ratings with similarity judgments. As expected, words from the same dominant modality were rated more similar than words from different dominant modalities; but – more importantly – this effect was enhanced when word pairs had high modality strength ratings. We further demonstrated the utility of our ratings by investigating whether perceptual modalities are differentially experienced in space, in a third study. Nouns were categorized into their dominant modality and used in a lexical decision experiment where the spatial position of words was either in proximal or distal space. We found words dominant in olfaction were processed faster in proximal than distal space compared to the other modalities, suggesting olfactory information is mentally simulated as “close” to the body. Finally, we collected ratings of emotion (valence, dominance, and arousal) to assess its role in perceptual space simulation, but the valence did not explain the data. So, words are processed differently depending on their perceptual associations, and strength of association is captured by modality exclusivity ratings.

Abstract

Spoken word recognition involves automatic activation of lexical candidates compatible with the perceived input. In running speech, words abut one another without intervening gaps, and syllable boundaries can mismatch with word boundaries. For instance, liaison in ’petit agneau’ creates a syllable beginning with a consonant although ’agneau’ begins with a vowel. In two cross-modal priming experiments we investigate how French listeners recognise words in liaison environments. These results suggest that the resolution of liaison in part depends on acoustic cues which distinguish liaison from non-liaison consonants, and in part on the availability of lexical support for a liaison interpretation.

Abstract

Background: Children with a diagnosis of attention-deficit hyperactivity disorder (ADHD) have lower cognitive ability and are at risk of adverse educational outcomes; ADHD genetic risks have been found to predict childhood cognitive ability and other neurodevelopmental traits in the general population; thus genetic risks might plausibly also contribute to cognitive ability later in development and to educational underachievement.

Methods: We generated ADHD polygenic risk scores in the Avon Longitudinal Study of Parents and Children participants (maximum N: 6928 children and 7280 mothers) based on the results of a discovery clinical sample, a genome-wide association study of 727 cases with ADHD diagnosis and 5081 controls. We tested if ADHD polygenic risk scores were associated with educational outcomes and IQ in adolescents and their mothers.

Results: High ADHD polygenic scores in adolescents were associated with worse educational outcomes at Key Stage 3 [national tests conducted at age 13–14 years; β = −1.4 (−2.0 to −0.8), P = 2.3 × 10−6), at General Certificate of Secondary Education exams at age 15–16 years (β = −4.0 (−6.1 to −1.9), P = 1.8 × 10−4], reduced odds of sitting Key Stage 5 examinations at age 16–18 years [odds ratio (OR) = 0.90 (0.88 to 0.97), P = 0.001] and lower IQ scores at age 15.5 [β = −0.8 (−1.2 to −0.4), P = 2.4 × 10−4]. Moreover, maternal ADHD polygenic scores were associated with lower maternal educational achievement [β = −0.09 (−0.10 to −0.06), P = 0.005] and lower maternal IQ [β = −0.6 (−1.2 to −0.1), P = 0.03].

Conclusions: ADHD diagnosis risk alleles impact on functional outcomes in two generations (mother and child) and likely have intergenerational environmental effects.

Abstract

Background: Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) symptoms and
autism spectrum disorder (ASD) symptoms have been reported. Cross-trait genetic relationships are, however,
subject to dynamic changes during development. We investigated the continuity of genetic overlap between ASD
and ADHD symptoms in a general population sample during childhood and adolescence. We also studied uni- and
cross-dimensional trait-disorder links with respect to genetic ADHD and ASD risk.
Methods: Social-communication difficulties (N ≤ 5551, Social and Communication Disorders Checklist, SCDC) and
combined hyperactive-impulsive/inattentive ADHD symptoms (N ≤ 5678, Strengths and Difficulties Questionnaire,
SDQ-ADHD) were repeatedly measured in a UK birth cohort (ALSPAC, age 7 to 17 years). Genome-wide summary
statistics on clinical ASD (5305 cases; 5305 pseudo-controls) and ADHD (4163 cases; 12,040 controls/pseudo-controls)
were available from the Psychiatric Genomics Consortium. Genetic trait variances and genetic overlap between
phenotypes were estimated using genome-wide data.
Results: In the general population, genetic influences for SCDC and SDQ-ADHD scores were shared throughout
development. Genetic correlations across traits reached a similar strength and magnitude (cross-trait rg ≤ 1,
pmin = 3 × 10−4) as those between repeated measures of the same trait (within-trait rg ≤ 0.94, pmin = 7 × 10−4).
Shared genetic influences between traits, especially during later adolescence, may implicate variants in K-RAS signalling
upregulated genes (p-meta = 6.4 × 10−4).
Uni-dimensionally, each population-based trait mapped to the expected behavioural continuum: risk-increasing alleles
for clinical ADHD were persistently associated with SDQ-ADHD scores throughout development (marginal regression
R2 = 0.084%). An age-specific genetic overlap between clinical ASD and social-communication difficulties during
childhood was also shown, as per previous reports. Cross-dimensionally, however, neither SCDC nor SDQ-ADHD scores
were linked to genetic risk for disorder.
Conclusions: In the general population, genetic aetiologies between social-communication difficulties and ADHD
symptoms are shared throughout child and adolescent development and may implicate similar biological pathways
that co-vary during development. Within both the ASD and the ADHD dimension, population-based traits are also linked
to clinical disorder, although much larger clinical discovery samples are required to reliably detect cross-dimensional
trait-disorder relationships.

Abstract

This article examines pediatrician-parent interaction in the context of acute pediatric encounters for children with upper respiratory infections. Parents and physicians orient to treatment recommendations as normatively requiring parent acceptance for physicians to close the activity. Through acceptance, withholding of acceptance, or active resistance, parents have resources with which to negotiate for a treatment outcome that is in line with their own wants. This article offers evidence that even in acute care, shared decision making not only occurs but, through normative constraints, is mandated for parents and physicians to reach accord in the treatment decision.

Abstract

In this article I examine one practice speakers have for confirming when confirmation was not otherwise relevant. The practice involves a speaker repeating an assertion previously made by another speaker in modified form with stress on the copula/auxiliary. I argue that these modified repeats work to undermine the first speaker's default ownership and rights over the claim and instead assert the primacy of the second speaker's rights to make the statement. Two types of modified repeats are identified: partial and full. Although both involve competing for primacy of the claim, they occur in distinct sequential environments: The former are generally positioned after a first claim was epistemically downgraded, whereas the latter are positioned following initial claims that were offered straightforwardly, without downgrading.

Abstract

That human social interaction involves the intertwined cooperation of different modalities is uncontroversial. Researchers in several allied fields have, however, only recently begun to document the precise ways in which talk, gesture, gaze, and aspects of the material surround are brought together to form coherent courses of action. The papers in this volume are attempts to develop this line of inquiry. Although the authors draw on a range of analytic, theoretical, and methodological traditions (conversation analysis, ethnography, distributed cognition, and workplace studies), all are concerned to explore and illuminate the inherently multimodal character of social interaction. Recent studies, including those collected in this volume, suggest that different modalities work together not only to elaborate the semantic content of talk but also to constitute coherent courses of action. In this introduction we present evidence for this position. We begin by reviewing some select literature focusing primarily on communicative functions and interactive organizations of specific modalities before turning to consider the integration of distinct modalities in interaction.

Abstract

This study draws on a database of 570 community-based acute pediatric encounters in the USA and uses conversation analysis as a methodology to identify two formats physicians use to recommend non-antibiotic treatment in acute pediatric care (using a subset of 309 cases): recommendations for particular treatment (e.g., “I’m gonna give her some cough medicine.”) and recommendations against particular treatment (e.g., “She doesn’t need any antibiotics.”). The findings are that the presentation of a specific affirmative recommendation for treatment is less likely to engender parent resistance to a non-antibiotic treatment recommendation than a recommendation against particular treatment even if the physician later offers a recommendation for particular treatment. It is suggested that physicians who provide a specific positive treatment recommendation followed by a negative recommendation are most likely to attain parent alignment and acceptance when recommending a non-antibiotic treatment for a viral upper respiratory illness.

Abstract

Speech of late bilinguals has frequently been described in terms of cross-linguistic influence (CLI) from the native language (L1) to the second language (L2), but CLI from the L2 to the L1 has received relatively little attention. This article addresses L2 attainment and L1 attrition in voicing systems through measures of voice onset time (VOT) in two groups of Dutch–German late bilinguals in the Netherlands. One group comprises native speakers of Dutch and the other group comprises native speakers of German, and the two groups further differ in their degree of L2 immersion. The L1-German–L2-Dutch bilinguals (N = 23) are exposed to their L2 at home and outside the home, and the L1-Dutch–L2-German bilinguals (N = 18) are only exposed to their L2 at home. We tested L2 attainment by comparing the bilinguals’ L2 to the other bilinguals’ L1, and L1 attrition by comparing the bilinguals’ L1 to Dutch monolinguals (N = 29) and German monolinguals (N = 27). Our findings indicate that complete L2 immersion may be advantageous in L2 acquisition, but at the same time it may cause L1 phonetic attrition. We discuss how the results match the predictions made by Flege’s Speech Learning Model and explore how far bilinguals’ success in acquiring L2 VOT and maintaining L1 VOT depends on the immersion context, articulatory constraints and the risk of sounding foreign accented.

Abstract

Listeners interpret utterances by integrating information from multiple sources including word level semantics and world knowledge. When the semantics of an expression is inconsistent with his or her knowledge about the world, the listener may have to search through the conceptual space for alternative possible world scenarios that can make the expression more acceptable. Such cognitive exploration requires considerable computational resources and might depend on motivational factors. This study explores whether and how oxytocin, a neuropeptide known to influence socialmotivation by reducing social anxiety and enhancing affiliative tendencies, can modulate the integration of world knowledge and sentence meanings. The study used a betweenparticipant double-blind randomized placebo-controlled design. Semantic integration, indexed with magnetoencephalography through the N400m marker, was quantified while 45 healthymale participants listened to sentences that were either congruent or incongruent with facts of the world, after receiving intranasally delivered oxytocin or placebo. Compared with congruent sentences, world knowledge incongruent sentences elicited a stronger N400m signal from the left inferior frontal and anterior temporal regions and medial pFC (the N400m effect) in the placebo group. Oxytocin administration significantly attenuated the N400meffect at both sensor and cortical source levels throughout the experiment, in a state-like manner. Additional electrophysiological markers suggest that the absence of the N400m effect in the oxytocin group is unlikely due to the lack of early sensory or semantic processing or a general downregulation of attention. These findings suggest that oxytocin drives listeners to resolve challenges of semantic integration, possibly by promoting the cognitive exploration of alternative possible world scenarios.

Abstract

Thirty-eight 3-, 6-, and 9-month-old infants interacted in a face to face situation with a female stranger who disrupted the on-going interaction with 30 s Happy and Neutral still face episodes. Three- and 6-month-olds manifested a robust still face response for gazing and smiling. For smiling, 9-month-olds manifested a floor effect such that no still face effect could be shown. For gazing, 9-month-olds' still face response was modulated by the context of interaction such that it was less pronounced if a happy still face was presented first. The findings point to a developmental transition by the end of the first year, whereby infants' still face response becomes increasingly influenced by the context of social interaction. (C) 2004 Published by Elsevier Inc. [References: 35]

Abstract

This study investigates whether spoken sentence comprehension deficits in Broca's aphasics results from their inability to access the subordinate meaning of ambiguous words (e.g. bank), or alternatively, from a delay in their selection of the contextually appropriate meaning. Twelve Broca's aphasics and twelve elderly controls were presented with lexical ambiguities in three context conditions, each followed by the same target words. In the concordant condition, the sentence context biased the meaning of the sentence final ambiguous word that was related to the target. In the discordant condition, the sentence context biased the meaning of the sentence final ambiguous word that was incompatible with the target.In the unrelated condition, the sentence-final word was unambiguous and unrelated to the target. The task of the subjects was to listen attentively to the stimuli The activational status of the ambiguous sentence-final words was inferred from the amplitude of the N399 to the targets at two inter-stimulus intervals (ISIs) (100 ms and 1250 ms). At the short ISI, the Broca's aphasics showed clear evidence of activation of the subordinate meaning. In contrast to elderly controls, however, the Broca's aphasics were not successful at selecting the appropriate meaning of the ambiguity in the short ISI version of the experiment. But at the long ISI, in accordance with the performance of the elderly controls, the patients were able to successfully complete the contextual selection process. These results indicate that Broca's aphasics are delayed in the process of contextual selection. It is argued that this finding of delayed selection is compatible with the idea that comprehension deficits in Broca's aphasia result from a delay in the process of integrating lexical information.

Abstract

This volume on Inuit speech follows the evolution of a native language of the North American Arctic, from its historical roots to its present-day linguistic structure and patterns of use from Alaska to Greenland. Drawing on a wide range of research from the fields of linguistics, anthropology, and sociology, Dorais integrates these diverse perspectives in a comprehensive view of native language development, maintenance, and use under conditions of marginalization due to social transition.

Abstract

Three experiments tested young children's efficiency in recognizing words in speech referring to absent objects. Seventy-two 24-month-olds heard sentences containing target words denoting objects that were or were not present in a visual display. Children's eye movements were monitored as they heard the sentences. Three distinct patterns of response were shown. Children hearing a familiar word that was an appropriate label for the currently fixated picture maintained their gaze. Children hearing a familiar word that could not apply to the currently fixated picture rapidly shifted their gaze to the alternative picture, whether that alternative was the named target or not, and then continued to search for an appropriate referent. Finally, children hearing an unfamiliar word shifted their gaze slowly and irregularly. This set of outcomes is interpreted as evidence that by 24 months, rapid activation in word recognition does not depend on the presence of the words' referents. Rather, very young children are capable of quickly and efficiently interpreting words in the absence of visual supporting context.

Abstract

Infants parse speech into word-sized units according to biases that develop in the first year. One bias, present before the age of 7 months, is to cluster syllables that tend to co-occur. The present computational research demonstrates that this statistical clustering bias could lead to the extraction of speech sequences that are actual words, rather than missegmentations. In English and Dutch, these word-forms exhibit the strong–weak (trochaic) pattern that guides lexical segmentation after 8 months, suggesting that the trochaic parsing bias is learned as a generalization from statistically extracted bisyllables, and not via attention to short utterances or to high-frequency bisyllables. Extracted word-forms come from various syntactic classes, and exhibit distributional characteristics enabling rudimentary sorting of words into syntactic categories. The results highlight the importance of infants’ first year in language learning: though they may know the meanings of very few words, infants are well on their way to building a vocabulary.

Abstract

During the first year of life, infants' perception of speech becomes tuned to the phonology of the native language, as revealed in laboratory discrimination and categorization tasks using syllable stimuli. However, the implications of these results for the development of the early vocabulary remain controversial, with some results suggesting that infants retain only vague, sketchy phonological representations of words. Five experiments using a preferential listening procedure tested Dutch 11-month-olds' responses to word, nonword and mispronounced-word stimuli. Infants listened longer to words than nonwords, but did not exhibit this response when words were mispronounced at onset or at offset. In addition, infants preferred correct pronunciations to onset mispronunciations. The results suggest that infants' encoding of familiar words includes substantial phonological detail.

Abstract

The degree to which infants represent phonetic detail in words has been a source of controversy in phonology and developmental psychology. One prominent hypothesis holds that infants store words in a vague or inaccurate form until the learning of similar–sounding neighbors forces attention to subtle phonetic distinctions. In the experiment reported here, we used a visual fixation task to assess word recognition. We present the first evidence indicating that, in fact, the lexical representations of 14– and 15–month–olds are encoded in fine detail, even when this detail is not functionally necessary for distinguishing similar words in the infant’s vocabulary. Exposure to words is sufficient for well–specified lexical representations, even well before the vocabulary spurt. These results suggest developmental continuity in infants’ representations of speech: As infants begin to build a vocabulary and learn word meanings, they use the perceptual abilities previously demonstrated in tasks testing the discrimination and categorization of meaningless syllables.

Abstract

Deep sequence-based imputation can enhance the discovery power of genome-wide association studies by assessing previously unexplored variation across the common- and low-frequency spectra. We applied a hybrid whole-genome sequencing (WGS) and deep imputation approach to examine the broader allelic architecture of 12 anthropometric traits associated with height, body mass, and fat distribution in up to 267,616 individuals. We report 106 genome-wide significant signals that have not been previously identified, including 9 low-frequency variants pointing to functional candidates. Of the 106 signals, 6 are in genomic regions that have not been implicated with related traits before, 28 are independent signals at previously reported regions, and 72 represent previously reported signals for a different anthropometric trait. 71% of signals reside within genes and fine mapping resolves 23 signals to one or two likely causal variants. We confirm genetic overlap between human monogenic and polygenic anthropometric traits and find signal enrichment in cis expression QTLs in relevant tissues. Our results highlight the potential of WGS strategies to enhance biologically relevant discoveries across the frequency spectrum.

Abstract

When a novel word is learned, its memory representation is thought to undergo a process of consolidation and integration. In this study, we tested whether the neural representations of novel words change as a function of consolidation by observing brain activation patterns just after learning and again after a delay of one week. Words learned with meanings were remembered better than those learned without meanings. Both episodic (hippocampus-dependent) and semantic (dependent on distributed neocortical areas) memory systems were utilised during recognition of the novel words. The extent to which the two systems were involved changed as a function of time and the amount of associated information, with more involvement of both systems for the meaningful words than for the form-only words after the one-week delay. These results suggest that the reason the meaningful words were remembered better is that their retrieval can benefit more from these two complementary memory systems

Abstract

Most experimental research making use of the Japanese language has involved the 1945 officially standardized kanji (Japanese logographic characters) in the Joyo kanji list (originally announced by the Japanese government in 1981). However, this list was extensively modified in 2010: five kanji were removed and 196 kanji were added; the latest revision of the list now has a total of 2136 kanji. Using an up-to-date corpus consisting of 11 years' worth of articles printed in the Mainichi Newspaper (2000-2010), we have constructed two novel databases that can be used in psychological research using the Japanese language: (1) a database containing a wide variety of properties on the latest 2136 Joyo kanji, and (2) a novel database containing 27,950 two-kanji compound words (or jukugo). Based on these two databases, we have created an interactive website (www.kanjidatabase.com) to retrieve and store linguistic information to be used in psychological and linguistic experiments. The present paper reports the most important characteristics for the new databases, as well as their value for experimental psychological and linguistic research.

Abstract

This study investigated the nature of the underlying working memory system supporting sentence processing through examining individual differences in sensitivity to retrieval interference effects during sentence comprehension. Interference effects occur when readers incorrectly retrieve sentence constituents which are similar to those required during integrative processes. We examined interference arising from a partial match between distracting constituents and syntactic and semantic cues, and related these interference effects to performance on working memory, short-term memory (STM), vocabulary, and executive function tasks. For online sentence comprehension, as measured by self-paced reading, the magnitude of individuals' syntactic interference effects was predicted by general WM capacity and the relation remained significant when partialling out vocabulary, indicating that the effects were not due to verbal knowledge. For offline sentence comprehension, as measured by responses to comprehension questions, both general WM capacity and vocabulary knowledge interacted with semantic interference for comprehension accuracy, suggesting that both general WM capacity and the quality of semantic representations played a role in determining how well interference was resolved offline. For comprehension question reaction times, a measure of semantic STM capacity interacted with semantic but not syntactic interference. However, a measure of phonological capacity (digit span) and a general measure of resistance to response interference (Stroop effect) did not predict individuals' interference resolution abilities in either online or offline sentence comprehension. The results are discussed in relation to the multiple capacities account of working memory (e.g., Martin and Romani, 1994; Martin and He, 2004), and the cue-based retrieval parsing approach (e.g., Lewis et al., 2006; Van Dyke et al., 2014). While neither approach was fully supported, a possible means of reconciling the two approaches and directions for future research are proposed.

Abstract

The great apes produce gestures intentionally and flexibly, and sometimes they combine their gestures into sequences, producing two or more gestures in close succession. We reevaluate previous findings related to ape gesture sequences and present qualitative analysis of videotaped gorilla interaction. We present evidence that gorillas produce at least two different kinds of gesture sequences: some sequences are largely composed of gestures that depict motion in an iconic manner, typically requesting particular action by the partner; others are multimodal and contain gestures – often percussive in nature – that are performed in situations of play or display. Display sequences seem to primarily exhibit the performer’s emotional state and physical fitness but have no immediate functional goal. Analysis reveals that some gorilla play and display sequences can be 1) organized hierarchically into longer bouts and repetitions; 2) innovative and individualized, incorporating objects and environmental features; and 3) highly interactive between partners. It is illuminating to look beyond ‘meaning’ in the conventional linguistic sense and look at the possibility that characteristics of music and dance, as well as those of language, are included in the gesturing of apes.

Abstract

Many environmental stimuli contain temporal regularities, a feature that can help predict forthcoming input. Phase locking (entrainment) of ongoing low-frequency neuronal oscillations to rhythmic stimuli is proposed as a potential mechanism for enhancing neuronal responses and perceptual sensitivity, by aligning high-excitability phases to events within a stimulus stream. Previous experiments show that rhythmic structure has a behavioral benefit even when the rhythm itself is below perceptual detection thresholds (ten Oever et al., 2014). It is not known whether this "inaudible" rhythmic sound stream also induces entrainment. Here we tested this hypothesis using magnetoencephalography and electrocorticography in humans to record changes in neuronal activity as subthreshold rhythmic stimuli gradually became audible. We found that significant phase locking to the rhythmic sounds preceded participants' detection of them. Moreover, no significant auditory-evoked responses accompanied this prethreshold entrainment. These auditory-evoked responses, distinguished by robust, broad-band increases in intertrial coherence, only appeared after sounds were reported as audible. Taken together with the reduced perceptual thresholds observed for rhythmic sequences, these findings support the proposition that entrainment of low-frequency oscillations serves a mechanistic role in enhancing perceptual sensitivity for temporally predictive sounds. This framework has broad implications for understanding the neural mechanisms involved in generating temporal predictions and their relevance for perception, attention, and awareness.

Abstract

This paper presents electrophysiological evidence of an impairment in the on-line processing of word class information in patients with Broca’s aphasia with agrammatic comprehension. Event-related brain potentials (ERPs) were recorded from the scalp while Broca patients and non-aphasic control subjects read open- and closed-class words that appeared one at a time on a PC screen. Separate waveforms were computed for open- and closed-class words. The non-aphasic control subjects showed a modulation of an early left anterior negativity in the 210–325 ms as a function of vocabulary class (VC), and a late left anterior negative shift to closed-class words in the 400–700 ms epoch. An N400 effect was present in both control subjects and Broca patients. We have taken the early electrophysiological differences to reflect the first availability of word-category information from the mental lexicon. The late differences can be related to post-lexical processing. In contrast to the control subjects, the Broca patients showed no early VC effect and no late anterior shift to closed-class words. The results support the view that an incomplete and/or delayed availability of word-class information might be an important factor in Broca’s agrammatic comprehension.

Abstract

The existence of nominal classification systems has long been thought of as one of the defining features of the Papuan languages of island New Guinea. However, while almost all of these languages do have nominal classification systems, they are, in fact, extremely divergent from each other. This paper examines these systems in the East Papuan languages in order to examine the question of the relationship between these Papuan outliers. Nominal classification systems are often archaic, preserving older features lost elsewhere in a language. Also, evidence shows that they are not easily borrowed into languages (although they can be). For these reasons, it is useful to consider nominal classification systems as a tool for exploring ancient historical relationships between languages. This paper finds little evidence of relationship between the nominal classification systems of the East Papuan languages as a whole. It argues that the mere existence of nominal classification systems cannot be used as evidence that the East Papuan languages form a genetic family. The simplest hypothesis is that either the systems were inherited so long ago as to obscure the genetic evidence, or else the appearance of nominal classification systems in these languages arose through borrowing of grammatical systems rather than of morphological forms.

Abstract

This paper explores the issue of documenting an endangered language from the perspective of a community with low levels of literacy, I first discuss the background of the language community with whom I work, the Lavukal people of Solomon Islands, and discuss whether, and to what extent, Lavukaleve is an endangered language. I then go on to discuss the documentation project. My main point is that while low literacy levels and a nonreading culture would seem to make documentation a strange choice as a tool for language maintenance, in fact both serve as powerful cultural symbols of the importance and prestige of Lavukaleve. It is well known that a common reason for language death is that speakers choose not to transmit their language to the next generation (e.g. Winter 1993). Lavukaleve is particularly vulnerable in this respect. By utilizing cultural symbols of status and prestige, the standing of Lavukaleve can be enhanced, thus helping to ensure the transmission of Lavukaleve to future generations.

Abstract

This study investigated different accounts of early argument structure acquisition and verb paradigm building through the detailed examination of the acquisition of the verb Go. Data from 11 children followed longitudinally between the ages of 2;0 and 3;0 were examined. Children's uses of the different forms of Go were compared with respect to syntactic structure and the semantics encoded. The data are compatible with the suggestion that the children were not operating with a single verb representation that differentiated between different forms of Go but rather that their knowledge of the relationship between the different forms of Go varied depending on the structure produced and the meaning encoded. However, a good predictor of the children's use of different forms of Go in particular structures and to express particular meanings was the frequency of use of those structures and meanings with particular forms of Go in the input. The implications of these findings for theories of syntactic category formation and abstract rule-based descriptions of grammar are discussed.

Abstract

This study examined patterns of auxiliary provision and omission for the auxiliaries BE and HAVE in a longitudinal data set from 11 children between the ages of two and three years. Four possible explanations for auxiliary omission—a lack of lexical knowledge, performance limitations in production, the Optional Infinitive hypothesis, and patterns of auxiliary use in the input—were examined. The data suggest that although none of these accounts provides a full explanation for the pattern of auxiliary use and nonuse observed in children's early speech, integrating input-based and lexical learning-based accounts of early language acquisition within a constructivist approach appears to provide a possible framework in which to understand the patterns of auxiliary use found in the children's speech. The implications of these findings for models of children's early language acquisition are discussed.

Abstract

Mendelian randomization (MR) requires strong assumptions about the genetic instruments, of which the most difficult to justify relate to pleiotropy. In a two-sample MR, different methods of analysis are available if we are able to assume, M1: no pleiotropy (fixed effects meta-analysis), M2: that there may be pleiotropy but that the average pleiotropic effect is zero (random effects meta-analysis), and M3: that the average pleiotropic effect is nonzero (MR-Egger). In the latter 2 cases, we also require that the size of the pleiotropy is independent of the size of the effect on the exposure. Selecting one of these models without good reason would run the risk of misrepresenting the evidence for causality. The most conservative strategy would be to use M3 in all analyses as this makes the weakest assumptions, but such an analysis gives much less precise estimates and so should be avoided whenever stronger assumptions are credible. We consider the situation of a two-sample design when we are unsure which of these 3 pleiotropy models is appropriate. The analysis is placed within a Bayesian framework and Bayesian model averaging is used. We demonstrate that even large samples of the scale used in genome-wide meta-analysis may be insufficient to distinguish the pleiotropy models based on the data alone. Our simulations show that Bayesian model averaging provides a reasonable trade-off between bias and precision. Bayesian model averaging is recommended whenever there is uncertainty about the nature of the pleiotropy

Abstract

In the current paper we report on a study of priming of variable Spanish 1sg subject expression in spontaneous Spanish–English bilingual speech (based on the New Mexico Spanish–English Bilingual corpus, Torres Cacoullos & Travis, in preparation). We show both within- and cross-language Coreferential Subject Priming; however, cross-language priming from English to Spanish is weaker and shorter lived than within-language Spanish-to-Spanish priming, a finding that appears not to be attributable to lexical boost. Instead, interactions with subject continuity and verb type show that the strength of priming depends on co-occurring contextual features and particular [pronoun + verb] constructions, from the more lexically specific to the more schematically general. Quantitative patterns in speech thus offer insights unavailable from experimental work into the scope and locus of priming effects, suggesting that priming in bilingual discourse can serve to gauge degrees of strength of within- and cross-language associations between usage-based constructions.

Abstract

This study investigates the convergent accommodating behaviour of Andalusian speakers (Southern Spain) relocated in Asturias (Northern Spain), a context of dialect contact, in terms of intonation. We aim to address three research questions: (1) is there evidence for accommodation? (2) Do social factors determine accommodation? And (3) does salience predict which prosodic features are more likely to be adopted by relocated speakers? We elaborated a corpus of spontaneous speech including an experimental group of Andalusian speakers in Asturias and two control groups of Asturian and Andalusian people. The relocated Andalusians were interviewed by a speaker of Andalusian Spanish and a speaker of Amestáu (hybrid variety between Asturian and Spanish), and their intonation patterns were compared to the ones found in the control populations. During the interviews, we also gathered data about how integrated these relocated speakers were in Asturias. We found that all participants show a tendency towards convergent accommodation to the Amestáu interlocutor, producing late falling pitch contours in nuclear position in declaratives and final falling contours in absolute interrogatives. The most integrated speakers in the Asturian community are the ones showing more features of the varieties spoken in the area. Finally, the most salient features to an Andalusian ear—the presence of final falls in Asturian, Asturian Spanish and Amestáu absolute interrogatives as opposed to final rises in Andalusian and Standard Peninsular Spanish—were the ones showing the highest percentages of adoption in relocated speakers. We could conclude, then, that the most salient prosodic features are acquired more easily by the most integrated relocated speakers.

Abstract

A central assumption in the perceptual attunement literature holds that exposure to a speech sound contrast leads to improvement in native speech sound processing. However, whether the amount of exposure matters for this process has not been put to a direct test. We elucidated indicators of frequency-dependent perceptual attunement by comparing 5–8-month-old Dutch infants’ discrimination of tokens containing a highly frequent [hɪt-he:t] and a highly infrequent [hʏt-hø:t] native vowel contrast as well as a non-native [hɛt-hæt] vowel contrast in a behavioral visual habituation paradigm (Experiment 1). Infants discriminated both native contrasts similarly well, but did not discriminate the non-native contrast. We sought further evidence for subtle differences in the processing of the two native contrasts using near-infrared spectroscopy and a within-participant design (Experiment 2). The neuroimaging data did not provide additional evidence that responses to native contrasts are modulated by frequency of exposure. These results suggest that even large differences in exposure to a native contrast may not directly translate to behavioral and neural indicators of perceptual attunement, raising the possibility that frequency of exposure does not influence improvements in discriminating native contrasts.

Abstract

Non-adjacent dependencies are challenging for the language learning machinery and are acquired later than adjacent dependencies. In this transcranial magnetic stimulation (TMS) study, we show that participants successfully discriminated between grammatical and non-grammatical sequences after having implicitly acquired an artificial language with crossed non-adjacent dependencies. Subsequent to transcranial magnetic stimulation of Broca’s region, discrimination was impaired compared to when a language-irrelevant control region (vertex) was stimulated. These results support the view that Broca’s region is engaged in structured sequence processing and extend previous functional neuroimaging results on artificial grammar learning (AGL) in two directions: first, the results establish that Broca’s region is a causal component in the processing of non-adjacent dependencies, and second, they show that implicit processing of non-adjacent dependencies engages Broca’s region. Since patients with lesions in Broca’s region do not always show grammatical processing difficulties, the result that Broca’s region is causally linked to processing of non-adjacent dependencies is a step towards clarification of the exact nature of syntactic deficits caused by lesions or perturbation to Broca’s region. Our findings are consistent with previous results and support a role for Broca’s region in general structured sequence processing, rather than a specific role for the processing of hierarchically organized sentence structure.

Abstract

The CNTNAP2 gene encodes a cell-adhesion molecule that influences the properties of neural networks and the morphology and density of neurons and glial cells. Previous studies have shown association of CNTNAP2 variants with language-related phenotypes in health and disease. Here, we report associations of a common CNTNAP2 polymorphism (rs7794745) with variation in grey matter in a region in the dorsal visual stream. We tried to replicate an earlier study on 314 subjects by Tan and colleagues (2010), but now in a substantially larger group of more than 1700 subjects. Carriers of the T allele showed reduced grey matter volume in left superior occipital gyrus, while we did not replicate associations with grey matter volume in other regions identified by Tan et al (2010). Our work illustrates the importance of independent replication in neuroimaging genetic studies of language-related candidate genes.

Abstract

Previous work has shown that novel morphologically complex words (henceforth neologisms) leave traces in memory after just one encounter. This study addressed the question whether these traces are abstract in nature or exemplars. In three experiments, neologisms were either primed by themselves or by their stems. The primes occurred in the visual modality whereas the targets were presented in the auditory modality (Experiment 1) or vice versa (Experiments 2 and 3). The primes were presented in sentences in a selfpaced reading task (Experiment 1) or in stories in a listening comprehension task (Experiments 2 and 3). The targets were incorporated in lexical decision tasks, auditory or visual (Experiment 1 and Experiment 2, respectively), or in stories in a self-paced reading task (Experiment 3). The experimental part containing the targets immediately followed the familiarization phase with the primes (Experiment 1), or after a one week delay (Experiments 2 and 3). In all experiments, participants recognized neologisms faster if they had encountered them before (identity priming) than if the familiarization phase only contained the neologisms’ stems (stem priming). These results show that the priming effects are robust despite substantial differences between the primes and the targets. This suggests that the traces novel morphologically complex words leave in memory after just one encounter are abstract in nature.

Abstract

People appear to have systematic associations between odors and colors. Previous research has emphasized the perceptual nature of these associations, but little attention has been paid to what role language might play. It is possible odor–color associations arise through a process of labeling; that is, participants select a descriptor for an odor and then choose a color accordingly (e.g., banana odor → “banana” label → yellow). If correct, this would predict odor–color associations would differ as odor descriptions differ. We compared speakers of Dutch (who overwhelmingly describe odors by referring to the source; e.g., smells like banana) with speakers of Maniq and Thai (who also describe odors with dedicated, abstract smell vocabulary; e.g., musty), and tested whether the type of descriptor mattered for odor–color associations. Participants were asked to select a color that they associated with an odor on two separate occasions (to test for consistency), and finally to label the odors. We found the hunter-gatherer Maniq showed few, if any, consistent or accurate odor–color associations. More importantly, we found the types of descriptors used to name the smells were related to the odor–color associations. When people used abstract smell terms to describe odors, they were less likely to choose a color match, but when they described an odor with a source-based term, their color choices more accurately reflected the odor source, particularly when the odor source was named correctly (e.g., banana odor → yellow). This suggests language is an important factor in odor–color cross-modal associations

Abstract

In normal conversation, speakers translate thoughts into words at high speed. To enable this speed, the retrieval of distinct types of linguistic knowledge has to be orchestrated with millisecond precision. The nature of this orchestration is still largely unknown. This report presents dynamic measures of the real-time activation of two basic types of linguistic knowledge, syntax and phonology. Electrophysiological data demonstrate that during noun-phrase production speakers retrieve the syntactic gender of a noun before its abstract phonological properties. This two-step process operates at high speed: the data show that phonological information is already available 40 milliseconds after syntactic properties have been retrieved.

Abstract

Social learning is predicted to evolve in socially living animals provided the learning process is not random but biased by certain socio-ecological factors. One bias of particular interest for the emergence of (cumulative) culture is the tendency to forgo personal behaviour in favour of relatively better variants observed in others, also known as the “copy-if-better” strategy. We investigated whether chimpanzees employ copy-if-better in a simple token-exchange paradigm controlling for individual and random social learning. After being trained on one token-type, subjects were confronted with a conspecific demonstrator who either received the same food reward as the subject (control condition) or a higher value food reward than the subject (test condition) for exchanging another token-type. In general, the chimpanzees persisted in exchanging the token-type they were trained on individually, indicating a form of conservatism consistent with previous studies. However, the chimpanzees were more inclined to copy the demonstrator in the test compared to the control condition, indicating a tendency to employ a copy-if-better strategy. We discuss the validity of our results by considering alternative explanations and relate our findings to the emergence of cumulative culture.

Abstract

An introductory study of the perception of stochastically specified events is reported. The initial problem was to determine whether the perceiver can split visual input data of this kind into random and determined components. The inability of subjects to do so with the stimulus material used (a filmlike sequence of dot patterns), led to the more general question of how subjects code this kind of visual material. To meet the difficulty of defining the subjects' responses, two experiments were designed. In both, patterns were presented as a rapid sequence of dots on a screen. The patterns were more or less disturbed by “noise,” i.e. the dots did not appear exactly at their proper places. In the first experiment the response was a rating on a semantic scale, in the second an identification from among a set of alternative patterns. The results of these experiments give some insight in the coding systems adopted by the subjects. First, noise appears to be detrimental to pattern recognition, especially to patterns with little spread. Second, this shows connections with the factors obtained from analysis of the semantic ratings, e.g. easily disturbed patterns show a large drop in the semantic regularity factor, when only a little noise is added.

Abstract

The ‘grooming handclasp’ is one of the most well-established cultural traditions in chimpanzees. A recent study by Wrangham et al. [1] reduced the cultural scope of grooming-handclasp behavior by showing that grooming-handclasp style convergence is “explained by matrilineal relationship rather than conformity” [1]. Given that we previously reported cultural differences in grooming-handclasp style preferences in captive chimpanzees [2], we tested the alternative view posed by Wrangham et al. [1] in the chimpanzee populations that our original results were based on. Using the same outcome variable as Wrangham et al. [1] — the proportion of high-arm grooming featuring palm-to-palm clasping — we found that matrilineal relationships explained neither within-group homogeneity nor between-group heterogeneity, thereby corroborating our original conclusion that grooming-handclasp behavior can represent a group-level cultural tradition in chimpanzees.

Abstract

Computer simulations in an instructional context can be characterized according to four aspects (themes): simulation models, learning goals, learning processes and learner activity. The present paper provides an outline of these four themes. The main classification criterion for simulation models is quantitative vs. qualitative models. For quantitative models a further subdivision can be made by classifying the independent and dependent variables as continuous or discrete. A second criterion is whether one of the independent variables is time, thus distinguishing dynamic and static models. Qualitative models on the other hand use propositions about non-quantitative properties of a system or they describe quantitative aspects in a qualitative way. Related to the underlying model is the interaction with it. When this interaction has a normative counterpart in the real world we call it a procedure. The second theme of learning with computer simulation concerns learning goals. A learning goal is principally classified along three dimensions, which specify different aspects of the knowledge involved. The first dimension, knowledge category, indicates that a learning goal can address principles, concepts and/or facts (conceptual knowledge) or procedures (performance sequences). The second dimension, knowledge representation, captures the fact that knowledge can be represented in a more declarative (articulate, explicit), or in a more compiled (implicit) format, each one having its own advantages and drawbacks. The third dimension, knowledge scope, involves the learning goal's relation with the simulation domain; knowledge can be specific to a particular domain, or generalizable over classes of domains (generic). A more or less separate type of learning goal refers to knowledge acquisition skills that are pertinent to learning in an exploratory environment. Learning processes constitute the third theme. Learning processes are defined as cognitive actions of the learner. Learning processes can be classified using a multilevel scheme. The first (highest) of these levels gives four main categories: orientation, hypothesis generation, testing and evaluation. Examples of more specific processes are model exploration and output interpretation. The fourth theme of learning with computer simulations is learner activity. Learner activity is defined as the ‘physical’ interaction of the learner with the simulations (as opposed to the mental interaction that was described in the learning processes). Five main categories of learner activity are distinguished: defining experimental settings (variables, parameters etc.), interaction process choices (deciding a next step), collecting data, choice of data presentation and metacontrol over the simulation.

Abstract

Three cross-modal priming experiments examined the role of suprasegmental information in the processing of spoken words. All primes consisted of truncated spoken Dutch words. Recognition of visually presented word targets was facilitated by prior auditory presentation of the first two syllables of the same words as primes, but only if they were appropriately stressed (e.g., OKTOBER preceded by okTO-); inappropriate stress, compatible with another word (e.g., OKTOBER preceded by OCto-, the beginning of octopus), produced inhibition. Monosyllabic fragments (e.g., OC-) also produced facilitation when appropriately stressed; if inappropriately stressed, they produced neither facilitation nor inhibition. The bisyllabic fragments that were compatible with only one word produced facilitation to semantically associated words, but inappropriate stress caused no inhibition of associates. The results are explained within a model of spoken-word recognition involving competition between simultaneously activated phonological representations followed by activation of separate conceptual representations for strongly supported lexical candidates; at the level of the phonological representations, activation is modulated by both segmental and suprasegmental information.

Abstract

The authors examined whether people can use their knowledge of the wider discourse rapidly enough to anticipate specific upcoming words as a sentence is unfolding. In an event-related brain potential (ERP) experiment, subjects heard Dutch stories that supported the prediction of a specific noun. To probe whether this noun was anticipated at a preceding indefinite article, stories were continued with a gender-marked adjective whose suffix mismatched the upcoming noun's syntactic gender. Prediction-inconsistent adjectives elicited a differential ERP effect, which disappeared in a no-discourse control experiment. Furthermore, in self-paced reading, prediction-inconsistent adjectives slowed readers down before the noun. These findings suggest that people can indeed predict upcoming words in fluent discourse and, moreover, that these predicted words can immediately begin to participate in incremental parsing operations.

Abstract

Earlier research has shown that established authors can be distinguished by measuring specific properties of their writings, their stylome as it were. Here, we examine writings of less experienced authors. We succeed in distinguishing between these authors with a very high probability, which implies that a stylome exists even in the general population. However, the number of traits needed for so successful a distinction is an order of magnitude larger than assumed so far. Furthermore, traits referring to syntactic patterns prove less distinctive than traits referring to vocabulary, but much more distinctive than expected on the basis of current generativist theories of language learning.

Abstract

This study examines whether heritage speakers of Turkish in the Netherlands interpret focus in written Dutch sentences differently from L1 speakers of Dutch (controls). Where most previous studies examined effects from the dominant L2 on the heritage language, we investigated whether there are effects from the weaker heritage language on the dominant L2. Dutch and Turkish differ in focus marking. Dutch primarily uses prosody to encode focus, whereas Turkish uses prosody and syntax, with a preverbal area for focused information and a postverbal area for background information. In written sentences no explicit prosody is available, which possibly enhances the role of syntactic cues in interpreting focus. An eye-tracking experiment suggests that, unlike the controls, the bilinguals associate the preverbal area with focus and the postverbal area with background information. These findings are in line with transfer from the weaker L1 to the dominant L2 at the syntax–discourse interface.

Abstract

Studies on heritage speakers generally reveal effects from the dominant L2 on the weaker L1, but it is less clear whether cross-linguistic transfer also occurs in the other direction: from the L1 to the dominant L2. This study explores whether the Dutch prosody of heritage speakers of Turkish in the Netherlands differs from that of L1 speakers of Dutch who do not speak Turkish, and whether observed differences could be attributed to an effect of Turkish. The experiment elicited semi-spontaneous sentences in broad and contrastive focus. The analysis included f0 movements, peak alignment, and duration. Although both participant groups used prosody to mark focus (e.g., time-compressed f0 movements for contrastive focus), there were also differences between the groups. For instance, while the L1 speakers of Dutch showed declination, the bilinguals remained at the same pitch level throughout the sentence. Ipek (2015) and Kamalı (2011) also noted a limited pitch range in the prenuclear area in Turkish. We argue that the prosodic differences could be due to an effect of Turkish on Dutch prosody, suggesting that the weaker L1 in Turkish heritage speakers may affect the dominant L2 in the prosodic domain.

Abstract

The use of computer simulations in education and training can have substantial advantages over other approaches. In comparison with alternatives such as textbooks, lectures, and tutorial courseware, a simulation-based approach offers the opportunity to learn in a relatively realistic problem-solving context, to practise task performance without stress, to systematically explore both realistic and hypothetical situations, to change the time-scale of events, and to interact with simplified versions of the process or system being simulated. However, learners are often unable to cope with the freedom offered by, and the complexity of, a simulation. As a result many of them resort to an unsystematic, unproductive mode of exploration. There is evidence that simulation-based learning can be improved if the learner is supported while working with the simulation. Constructing such an instructional environment around simulations seems to run counter to the freedom the learner is allowed to in ‘stand alone’ simulations. The present article explores instructional measures that allow for an optimal freedom for the learner. An extensive discussion of learning goals brings two main types of learning goals to the fore: conceptual knowledge and operational knowledge. A third type of learning goal refers to the knowledge acquisition (exploratory learning) process. Cognitive theory has implications for the design of instructional environments around simulations. Most of these implications are quite general, but they can also be related to the three types of learning goals. For conceptual knowledge the sequence and choice of models and problems is important, as is providing the learner with explanations and minimization of error. For operational knowledge cognitive theory recommends learning to take place in a problem solving context, the explicit tracing of the behaviour of the learner, providing immediate feedback and minimization of working memory load. For knowledge acquisition goals, it is recommended that the tutor takes the role of a model and coach, and that learning takes place together with a companion. A second source of inspiration for designing instructional environments can be found in Instructional Design Theories. Reviewing these shows that interacting with a simulation can be a part of a more comprehensive instructional strategy, in which for example also prerequisite knowledge is taught. Moreover, information present in a simulation can also be represented in a more structural or static way and these two forms of presentation provoked to perform specific learning processes and learner activities by tutor controlled variations in the simulation, and by tutor initiated prodding techniques. And finally, instructional design theories showed that complex models and procedures can be taught by starting with central and simple elements of these models and procedures and subsequently presenting more complex models and procedures. Most of the recent simulation-based intelligent tutoring systems involve troubleshooting of complex technical systems. Learners are supposed to acquire knowledge of particular system principles, of troubleshooting procedures, or of both. Commonly encountered instructional features include (a) the sequencing of increasingly complex problems to be solved, (b) the availability of a range of help information on request, (c) the presence of an expert troubleshooting module which can step in to provide criticism on learner performance, hints on the problem nature, or suggestions on how to proceed, (d) the option of having the expert module demonstrate optimal performance afterwards, and (e) the use of different ways of depicting the simulated system. A selection of findings is summarized by placing them under the four themes we think to be characteristic of learning with computer simulations (see de Jong, this volume).