Publications

Displaying 1 - 100 of 328
  • Abdel Rahman, R., Sommer, W., & Schweinberger, S. R. (2002). Brain potential evidence for the time course of access to biographical facts and names of familiar persons. Journal of Experimental Psychology: Learning, Memory, and Cognition, 28(2), 366-373. doi:10.1037//0278-7393.28.2.366.

    Abstract

    On seeing familiar persons, biographical (semantic) information is typically retrieved faster and more accurately than name information. Serial stage models explain this pattern by suggesting that access to the name follows the retrieval of semantic information. In contrast, interactive activation and competition (IAC) models hold that both processes start together but name retrieval is slower because of structural peculiarities. With a 2-choice go/no-go procedure based on a semantic and a name-related classification, the authors tested differential predictions of the 2 alternative models for reaction times (RTs) and lateralized readiness potentials (LRP). Both LRP (Experiment 1) and RT (Experiment 2) results are in line with IAC models of face identification and naming.
  • Almeida, L., Amdal, I., Beires, N., Boualem, M., Boves, L., Den Os, E., Filoche, P., Gomes, R., Knudsen, J. E., Kvale, K., Rugelbak, J., Tallec, C., & Warakagoda, N. (2002). Implementing and evaluating a multimodal tourist guide. In J. v. Kuppevelt, L. Dybkjær, & N. Bernsen (Eds.), Proceedings of the International CLASS Workshop on Natural, Intelligent and Effective Interaction in Multimodal Dialogue System (pp. 1-7). Copenhagen: Kluwer.
  • Ameka, F. K. (2002). The progressive aspect in Likpe: Its implications for aspect and word order in Kwa. In F. K. Ameka, & E. K. Osam (Eds.), New directions in Ghanaian linguistics: Essays in honor of the 3Ds (pp. 85-111). Accra: Black Mask.
  • Ameka, F. K. (1989). [Review of The case for lexicase: An outline of lexicase grammatical theory by Stanley Starosta]. Studies in Language, 13(2), 506-518.
  • Ameka, F. K. (2002). Cultural scripting of body parts for emotions: On 'jealousy' and related emotions in Ewe. Pragmatics and Cognition, 10(1-2), 27-55. doi:10.1075/pc.10.12.03ame.

    Abstract

    Different languages present a variety of ways of talking about emotional experience. Very commonly, feelings are described through the use of ‘body image constructions’ in which they are associated with processes in, or states of, specific body parts. The emotions and the body parts that are thought to be their locus and the kind of activity associated with these body parts vary cross-culturally. This study focuses on the meaning of three ‘body image constructions’ used to describe feelings similar to, but also different from, English ‘jealousy’, ‘envy’, and ‘covetousness’ in the West African language Ewe. It is demonstrated that a ‘moving body’, a pychologised eye, and red eyes are scripted for these feelings. It is argued that the expressions are not figurative and that their semantics provide good clues to understanding the cultural construction of emotions both emotions and the body.
  • Ameka, F. K. (2002). Constituent order and grammatical relations in Ewe in typological perspective. In K. Davidse, & B. Lamiroy (Eds.), The nominative & accusative and their counterparts (pp. 319-352). Amsterdam: John Benjamins.
  • Ameka, F. K., & Osam, E. K. (2002). New directions in Ghanaian linguistics: Essays in honour of the 3Ds: M.E. Kropp Dakubu, Florence Abena Dolphyne, Alan Stewart Duthie. Accra: Black Mask Ltd.
  • Bastiaansen, M. C. M., Van Berkum, J. J. A., & Hagoort, P. (2002). Syntactic processing modulates the θ rhythm of the human EEG. NeuroImage, 17, 1479-1492. doi:10.1006/nimg.2002.1275.

    Abstract

    Changes in oscillatory brain dynamics can be studied by means of induced band power (IBP) analyses, which quantify event-related changes in amplitude of frequency-specific EEG rhythms. Such analyses capture EEG phenomena that are not part of traditional event-related potential measures. The present study investigated whether IBP changes in the δ, θ, and α frequency ranges are sensitive to syntactic violations in sentences. Subjects read sentences that either were correct or contained a syntactic violation. The violations were either grammatical gender agreement violations, where a prenominal adjective was not appropriately inflected for the head noun's gender, or number agreement violations, in which a plural quantifier was combined with a singular head noun. IBP changes of the concurrently measured EEG were computed in five frequency bands of 2-Hz width, individually adjusted on the basis of subjects' α peak, ranging approximately from 2 to 12 Hz. Words constituting a syntactic violation elicited larger increases in θ power than the same words in a correct sentence context, in an interval of 300–500 ms after word onset. Of all the frequency bands studied, this was true for the θ frequency band only. The scalp topography of this effect was different for different violations: following number violations a left-hemispheric dominance was found, whereas gender violations elicited a right-hemisphere dominance of the θ power increase. Possible interpretations of this effect are considered in closing.
  • Bastiaansen, M. C. M., Posthuma, D., Groot, P. F. C., & De Geus, E. J. C. (2002). Event-related alpha and theta responses in a visuo-spatial working memory task. Clinical Neurophysiology, 113(12), 1882-1893. doi:10.1016/S1388-2457(02)00303-6.

    Abstract

    Objective: To explore the reactivity of the theta and alpha rhythms during visuo-spatial working memory. Methods: One hundred and seventy-four subjects performed a delayed response task. They had to remember the spatial location of a target stimulus on a computer screen for a 1 or a 4 s retention interval. The target either remained visible throughout the entire interval (sensory trials) or disappeared after 150 ms (memory trials). Changes in induced band power (IBP) in the electroencephalogram (EEG) were analyzed in 4 narrow, individually adjusted frequency bands between 4 and 12 Hz. Results: After presentation of the target stimulus, a phasic power increase was found, irrespective of condition and delay interval, in the lower (roughly, 4–8 Hz) frequency bands, with a posterior maximum. During the retention interval, sustained occipital–parietal alpha power increase and frontal theta power decrease were found. Most importantly, the memory trials showed larger IBP decreases in the theta band over frontal electrodes than the sensory trials. Conclusions: The phasic power increase following target onset is interpreted to reflect encoding of the target location. The sustained theta decrease, which is larger for memory trials, is tentatively interpreted to reflect visuo-spatial working memory processes.
  • Bastiaansen, M. C. M., Van Berkum, J. J. A., & Hagoort, P. (2002). Event-related theta power increases in the human EEG during online sentence processing. Neuroscience Letters, 323(1), 13-16. doi:10.1016/S0304-3940(01)02535-6.

    Abstract

    By analyzing event-related changes in induced band power in narrow frequency bands of the human electroencephalograph, the present paper explores a possible functional role of the alpha and theta rhythms during the processing of words and of sentences. The results show a phasic power increase in the theta frequency range, together with a phasic power decrease in the alpha frequency range, following the presentation of words in a sentence. These effects may be related to word processing, either lexical or in relation to sentence context. Most importantly, there is a slow and highly frequency-specific increase in theta power as a sentence unfolds, possibly related to the formation of an episodic memory trace, or to incremental verbal working memory load.
  • Bastiaansen, M. C. M., Böcker, K. B. E., & Brunia, C. H. M. (2002). ERD as an index of anticipatory attention? Effects of stimulus degradation. Psychophysiology, 39(1), 16-28. doi:10.1111/1469-8986.3910016.

    Abstract

    Previous research has suggested that the stimulus-preceding negativity (SPN) is largely independent of stimulus modality. In contrast, the scalp topography of the event related desynchronization (ERD) related to the anticipation of stimuli providing knowledge of results (KR) is modality dependent. These findings, combined with functional SPN research, lead to the hypothesis that anticipatory ERD reflects anticipatory attention, whereas the SPN mainly depends on the affective-motivational properties of the anticipated stimulus. To further investigate the prestimulus ERD, and compare this measure with the SPN, 12 participants performed a time-estimation task, and were informed about the quality of their time estimation by an auditory or a visual stimulus providing KR. The KR stimuli could be either intact or degraded. Auditory degraded KR stimuli were less effective than other KR stimuli in guiding subsequent behavior, and were preceded by a larger SPN. There were no effects of degradation on the SPN in the visual modality. Preceding auditory KR stimuli no ERD was present, whereas preceding visual stimuli an occipital ERD was found. However, contrary to expectation, the latter was larger preceding intact than preceding degraded stimuli. It is concluded that the data largely agree with an interpretation of the pre-KR SPN as a reflection of the anticipation of the affective-motivational value of KR stimuli, and of the prestimulus ERD as a perceptual anticipatory attention process.
  • Bauer, B. L. M. (2002). Variability in word order: Adjectives and comparatives in Latin, Romance, and Germanic. Southwest Journal of Linguistics, 20, 19-50.
  • Belke, E., & Meyer, A. S. (2002). Tracking the time course of multidimensional stimulus discrimination: Analyses of viewing patterns and processing times during "same''-"different'' decisions. European Journal of Cognitive Psychology, 14(2), 237-266. doi:10.1080/09541440143000050.

    Abstract

    We investigated the time course of conjunctive ''same''-''different'' judgements for visually presented object pairs by means of combined reaction time and on-line eye movement measurements. The analyses of viewing patterns, viewing times, and reaction times showed that participants engaged in a parallel self-terminating search for differences. In addition, the results obtained for objects differing in only one dimension suggest that processing times may depend on the relative codability of the stimulus dimensions. The results are reviewed in a broader framework in view of higher-order processes. We propose that overspecifications of colour, often found in object descriptions, may have an ''early'' visual rather than a ''late'' linguistic origin. In a parallel assessment of the detection materials, participants overspecified the objects' colour substantially more often than their size. We argue that referential overspecifications of colour are largely attributable to mechanisms of visual discrimination.
  • Bock, K., & Levelt, W. J. M. (2002). Language production: Grammatical encoding. In G. T. Altmann (Ed.), Psycholinguistics: Critical concepts in psychology (pp. 405-452). London: Routledge.
  • Bohnemeyer, J. (2002). The grammar of time reference in Yukatek Maya. Munich: LINCOM.
  • Bohnemeyer, J., & Majid, A. (2002). ECOM causality revisited version 4. In S. Kita (Ed.), 2002 Supplement (version 3) for the “Manual” for the field season 2001 (pp. 35-38). Nijmegen: Max Planck Institute for Psycholinguistics.
  • Bohnemeyer, J. (2002). [Review of the book Explorations in linguistic relativity ed. by Martin Pütz and Marjolijn H. Verspoor]. Language in Society, 31(3), 452-456. doi:DOI: 10.1017.S004740502020316502020316.
  • Bohnemeyer, J., Kelly, A., & Abdel Rahman, R. (2002). Max-Planck-Institute for Psycholinguistics: Annual Report 2002. Nijmegen: MPI for Psycholinguistics.
  • Bowerman, M. (2002). Taalverwerving, cognitie en cultuur. In T. Janssen (Ed.), Taal in gebruik: Een inleiding in de taalwetenschap (pp. 27-44). The Hague: Sdu.
  • Bowerman, M., Brown, P., Eisenbeiss, S., Narasimhan, B., & Slobin, D. I. (2002). Putting things in places: Developmental consequences of linguistic typology. In E. V. Clark (Ed.), Proceedings of the 31st Stanford Child Language Research Forum. Space in language location, motion, path, and manner (pp. 1-29). Stanford: Center for the Study of Language & Information.

    Abstract

    This study explores how adults and children describe placement events (e.g., putting a book on a table) in a range of different languages (Finnish, English, German, Russian, Hindi, Tzeltal Maya, Spanish, and Turkish). Results show that the eight languages grammatically encode placement events in two main ways (Talmy, 1985, 1991), but further investigation reveals fine-grained crosslinguistic variation within each of the two groups. Children are sensitive to these finer-grained characteristics of the input language at an early age, but only when such features are perceptually salient. Our study demonstrates that a unitary notion of 'event' does not suffice to characterize complex but systematic patterns of event encoding crosslinguistically, and that children are sensitive to multiple influences, including the distributional properties of the target language, in constructing these patterns in their own speech.
  • Bowerman, M. (1985). Beyond communicative adequacy: From piecemeal knowledge to an integrated system in the child's acquisition of language. In K. Nelson (Ed.), Children's language (pp. 369-398). Hillsdale, N.J.: Lawrence Erlbaum.

    Abstract

    (From the chapter) the first section considers very briefly the kinds of processes that can be inferred to underlie errors that do not set in until after a period of correct usage acquisition often seems to be a more extended process than we have envisioned summarize a currently influential model of how linguistic forms, meaning, and communication are interrelated in the acquisition of language, point out some challenging problems for this model, and suggest that the notion of "meaning" in language must be reconceptualized before we can hope to solve these problems evidence from several types of late errors is marshalled in support of these arguments (From the preface) provides many examples of new errors that children introduce at relatively advanced stages of mastery of semantics and syntax Bowerman views these seemingly backwards steps as indications of definite steps forward by the child achieving reflective, flexible and integrated systems of semantics and syntax (
  • Bowerman, M. (1975). Cross linguistic similarities at two stages of syntactic development. In E. Lenneberg, & E. Lenneberg (Eds.), Foundations of language development: A multidisciplinary approach (pp. 267-282). New York: Academic Press.
  • Bowerman, M. (1973). Early syntactic development: A cross linguistic study with special reference to Finnish. Cambridge: Cambridge University Press.

    Abstract

    First published in 1973, this important work was the first systematic attempt to apply theoretical and methodological tools developed in America to the acquisition of a language other than English. Dr Bowerman presents and analyses data from a longitudinal investigation of the early syntactic development of two Finnish children, and compares their speech at two stages of development with that of American, Samoan and Luo children. The four language families (Finno-Ugric, Indo-European, Malayo-Polynesian and Nilotic respectively) with very different structures, and this is the first systematic comparison of the acquisition of several types of native language within a common analysis. Similarities in the linguistic behaviour of children learning these four different languages are used to evaluate hypotheses about universals of language, and to generate new proposals.
  • Bowerman, M. (1975). Commentary on L. Bloom, P. Lightbown, & L. Hood, “Structure and variation in child language”. Monographs of the Society for Research in Child Development, 40(2), 80-90. Retrieved from http://www.jstor.org/stable/1165986.
  • Bowerman, M. (1973). [Review of Lois Bloom, Language development: Form and function in emerging grammars (MIT Press 1970)]. American Scientist, 61(3), 369-370.
  • Bowerman, M. (2002). Mapping thematic roles onto syntactic functions: Are children helped by innate linking rules? [Reprint]. In Mouton Classics: From syntax to cognition, from phonology to text (vol.2) (pp. 495-531). Berlin: Mouton de Gruyter.

    Abstract

    Reprinted from: Bowerman, M. (1990). Mapping thematic roles onto syntactic functions: Are children helped by innate linking rules? Linguistics, 28, 1253-1289.
  • Bowerman, M. (1989). Learning a semantic system: What role do cognitive predispositions play? In M. L. Rice, & R. L. Schiefelbusch (Eds.), The teachability of language (pp. 133-169). Baltimore: Paul H. Brookes.
  • Bowerman, M. (1973). Structural relationships in children's utterances: Semantic or syntactic? In T. Moore (Ed.), Cognitive development and the acquisition of language (pp. 197-213). New York: Academic Press.
  • Bowerman, M. (1985). What shapes children's grammars? In D. Slobin (Ed.), The crosslinguistic study of language acquisition (pp. 1257-1319). Hillsdale, N.J.: Lawrence Erlbaum.
  • Broeder, D., Offenga, F., & Willems, D. (2002). Metadata tools supporting controlled vocabulary services. In M. Rodriguez González, & C. Paz SuárezR Araujo (Eds.), Third international conference on language resources and evaluation (pp. 1055-1059). Paris: European Language Resources Association.

    Abstract

    Within the ISLE Metadata Initiative (IMDI) project a user-friendly editor to enter metadata descriptions and a browser operating on the linked metadata descriptions were developed. Both tools support the usage of Controlled Vocabulary (CV) repositories by means of the specification of an URL where the formal CV definition data is available.
  • Broeder, D., Wittenburg, P., Declerck, T., & Romary, L. (2002). LREP: A language repository exchange protocol. In M. Rodriguez González, & C. Paz Suárez Araujo (Eds.), Third international conference on language resources and evaluation (pp. 1302-1305). Paris: European Language Resources Association.

    Abstract

    The recent increase in the number and complexity of the language resources available on the Internet is followed by a similar increase of available tools for linguistic analysis. Ideally the user does not need to be confronted with the question in how to match tools with resources. If resource repositories and tool repositories offer adequate metadata information and a suitable exchange protocol is developed this matching process could be performed (semi-) automatically.
  • Broersma, M. (2002). Comprehension of non-native speech: Inaccurate phoneme processing and activation of lexical competitors. In ICSLP-2002 (pp. 261-264). Denver: Center for Spoken Language Research, U. of Colorado Boulder.

    Abstract

    Native speakers of Dutch with English as a second language and native speakers of English participated in an English lexical decision experiment. Phonemes in real words were replaced by others from which they are hard to distinguish for Dutch listeners. Non-native listeners judged the resulting near-words more often as a word than native listeners. This not only happened when the phonemes that were exchanged did not exist as separate phonemes in the native language Dutch, but also when phoneme pairs that do exist in Dutch were used in word-final position, where they are not distinctive in Dutch. In an English bimodal priming experiment with similar groups of participants, word pairs were used which differed in one phoneme. These phonemes were hard to distinguish for the non-native listeners. Whereas in native listening both words inhibited each other, in non-native listening presentation of one word led to unresolved competition between both words. The results suggest that inaccurate phoneme processing by non-native listeners leads to the activation of spurious lexical competitors.
  • Brown, C. M., & Hagoort, P. (1989). De LAT-relatie tussen lichaam en geest: Over de implicaties van neurowetenschap voor onze kennis van cognitie. In C. Brown, P. Hagoort, & T. Meijering (Eds.), Vensters op de geest: Cognitie op het snijvlak van filosofie en psychologie (pp. 50-81). Utrecht: Grafiet.
  • Brown, P. (1989). [Review of the book Language, gender, and sex in comparative perspective ed. by Susan U. Philips, Susan Steeleand Christine Tanz]. Man, 24(1), 192.
  • Brown, P. (2002). Everyone has to lie in Tzeltal. In S. Blum-Kulka, & C. E. Snow (Eds.), Talking to adults: The contribution of multiparty discourse to language acquisition (pp. 241-275). Mahwah, NJ: Erlbaum.

    Abstract

    In a famous paper Harvey Sacks (1974) argued that the sequential properties of greeting conventions, as well as those governing the flow of information, mean that 'everyone has to lie'. In this paper I show this dictum to be equally true in the Tzeltal Mayan community of Tenejapa, in southern Mexico, but for somewhat different reasons. The phenomenon of interest is the practice of routine fearsome threats to small children. Based on a longitudinal corpus of videotaped and tape-recorded naturally-occurring interaction between caregivers and children in five Tzeltal families, the study examines sequences of Tzeltal caregivers' speech aimed at controlling the children's behaviour and analyzes the children's developing pragmatic skills in handling such controlling utterances, from prelinguistic infants to age five and over. Infants in this society are considered to be vulnerable, easily scared or shocked into losing their 'souls', and therefore at all costs to be protected and hidden from outsiders and other dangers. Nonetheless, the chief form of control (aside from physically removing a child from danger) is to threaten, saying things like "Don't do that, or I'll take you to the clinic for an injection," These overt scare-threats - rarely actually realized - lead Tzeltal children by the age of 2;6 to 3;0 to the understanding that speech does not necessarily convey true propositions, and to a sensitivity to the underlying motivations for utterances distinct from their literal meaning. By age 4;0 children perform the same role to their younger siblings;they also begin to use more subtle non-true (e.g. ironic) utterances. The caretaker practice described here is related to adult norms of social lying, to the sociocultural context of constraints on information flow, social control through gossip, and the different notion of 'truth' that arises in the context of non-verifiability characteristic of a small-scale nonliterate society.
  • Brown, P. (2002). Language as a model for culture: Lessons from the cognitive sciences. In R. G. Fox, & B. J. King (Eds.), Anthropology beyond culture (pp. 169-192). Oxford: Berg.

    Abstract

    This paper surveys the concept of culture as used in recent work in cognitive science, assessing the very different (and sometimes minimal) role 'culture' plays in different branches and schools of linguistics: generative approaches, descriptive/comparative linguistics, typology, cognitive linguistics, semantics, pragmatics, psycholinguistics, linguistic and cognitive anthropology. The paper then describes research on one specific topic, spatial language and conceptualization, describes a methodology for studying it cross-linguistically and cross-culturally. Finally, it considers the implications of results in this area for how we can fruitfully conceptualize 'culture', arguing for an approach which shifts back and forth between individual mind and collective representations, between universals and particulars, and ties 'culture' to our biological roots.
  • Brugman, H., Levinson, S. C., Skiba, R., & Wittenburg, P. (2002). The DOBES archive: It's purpose and implementation. In P. Austin, H. Dry, & P. Wittenburg (Eds.), Proceedings of the international LREC workshop on resources and tools in field linguistics (pp. 11-11). Paris: European Language Resources Association.
  • Brugman, H., Spenke, H., Kramer, M., & Klassmann, A. (2002). Multimedia annotation with multilingual input methods and search support.
  • Brugman, H., Wittenburg, P., Levinson, S. C., & Kita, S. (2002). Multimodal annotations in gesture and sign language studies. In M. Rodriguez González, & C. Paz Suárez Araujo (Eds.), Third international conference on language resources and evaluation (pp. 176-182). Paris: European Language Resources Association.

    Abstract

    For multimodal annotations an exhaustive encoding system for gestures was developed to facilitate research. The structural requirements of multimodal annotations were analyzed to develop an Abstract Corpus Model which is the basis for a powerful annotation and exploitation tool for multimedia recordings and the definition of the XML-based EUDICO Annotation Format. Finally, a metadata-based data management environment has been setup to facilitate resource discovery and especially corpus management. Bt means of an appropriate digitization policy and their online availability researchers have been able to build up a large corpus covering gesture and sign language data.
  • Cablitz, G. (2002). The acquisition of an absolute system: learning to talk about space in Marquesan (Oceanic, French Polynesia). In E. V. Clark (Ed.), Space in language location, motion, path, and manner (pp. 40-49). Stanford: Center for the Study of Language & Information (Electronic proceedings.
  • Cablitz, G. (2002). Marquesan: A grammar of space. PhD Thesis, Christian Albrechts U., Kiel.
  • Chen, A., Gussenhoven, C., & Rietveld, T. (2002). Language-specific uses of the effort code. In B. Bel, & I. Marlien (Eds.), Proceedings of the 1st Conference on Speech Prosody (pp. 215-218). Aix=en-Provence: Université de Provence.

    Abstract

    Two groups of listeners with Dutch and British English language backgrounds judged Dutch and British English utterances, respectively, which varied in the intonation contour on the scales EMPHATIC vs. NOT EMPHATIC and SURPRISED vs. NOT SURPRISED, two meanings derived from the Effort Code. The stimuli, which differed in sentence mode but were otherwise lexically equivalent, were varied in peak height, peak alignment, end pitch, and overall register. In both languages, there are positive correlations between peak height and degree of emphasis, between peak height and degree of surprise, between peak alignment and degree of surprise, and between pitch register and degree of surprise. However, in all these cases, Dutch stimuli lead to larger perceived meaning differences than the British English stimuli. This difference in the extent to which increased pitch height triggers increases in perceived emphasis and surprise is argued to be due to the difference in the standard pitch ranges between Dutch and British English. In addition, we found a positive correlation between pitch register and the degree of emphasis in Dutch, but a negative correlation in British English. This is an unexpected difference, which illustrates a case of ambiguity in the meaning of pitch.
  • Cho, T. (2002). The effects of prosody on articulation in English. New York: Routledge.
  • Cho, T., Jun, S.-A., & Ladefoged, P. (2002). Acoustic and aerodynamic correlates of Korean stops and fricatives. Journal of Phonetics, 30(2), 193-228. doi:10.1006/jpho.2001.0153.

    Abstract

    This study examines acoustic and aerodynamic characteristics of consonants in standard Korean and in Cheju, an endangered Korean language. The focus is on the well-known three-way distinction among voiceless stops (i.e., lenis, fortis, aspirated) and the two-way distinction between the voiceless fricatives /s/ and /s*/. While such a typologically unusual contrast among voiceless stops has long drawn the attention of phoneticians and phonologists, there is no single work in the literature that discusses a body of data representing a relatively large number of speakers. This study reports a variety of acoustic and aerodynamic measures obtained from 12 Korean speakers (four speakers of Seoul Korean and eight speakers of Cheju). Results show that, in addition to findings similar to those reported by others, there are three crucial points worth noting. Firstly, lenis, fortis, and aspirated stops are systematically differentiated from each other by the voice quality of the following vowel. Secondly, these stops are also differentiated by aerodynamic mechanisms. The aspirated and fortis stops are similar in supralaryngeal articulation, but employ a different relation between intraoral pressure and flow. Thirdly, our study suggests that the fricative /s/ is better categorized as “lenis” rather than “aspirated”. The paper concludes with a discussion of the implications of Korean data for theories of the voicing contrast and their phonological representations.
  • Clahsen, H., Prüfert, P., Eisenbeiss, S., & Cholin, J. (2002). Strong stems in the German mental lexicon: Evidence from child language acquisition and adult processing. In I. Kaufmann, & B. Stiebels (Eds.), More than words. Festschrift for Dieter Wunderlich (pp. 91-112). Berlin: Akadamie Verlag.
  • Cooper, N., Cutler, A., & Wales, R. (2002). Constraints of lexical stress on lexical access in English: Evidence from native and non-native listeners. Language and Speech, 45(3), 207-228.

    Abstract

    Four cross-modal priming experiments and two forced-choice identification experiments investigated the use of suprasegmental cues to stress in the recognition of spoken English words, by native (English-speaking) and non- native (Dutch) listeners. Previous results had indicated that suprasegmental information was exploited in lexical access by Dutch but not by English listeners. For both listener groups, recognition of visually presented target words was faster, in comparison to a control condition, after stress-matching spoken primes, either monosyllabic (mus- from MUsic /muSEum) or bisyl labic (admi- from ADmiral/admiRAtion). For native listeners, the effect of stress-mismatching bisyllabic primes was not different from that of control primes, but mismatching monosyllabic primes produced partial facilitation. For non-native listeners, both bisyllabic and monosyllabic stress-mismatching primes produced partial facilitation. Native English listeners thus can exploit suprasegmental information in spoken-word recognition, but information from two syllables is used more effectively than information from one syllable. Dutch listeners are less proficient at using suprasegmental information in English than in their native language, but, as in their native language, use mono- and bisyllabic information to an equal extent. In forced-choice identification, Dutch listeners outperformed native listeners at correctly assigning a monosyllabic fragment (e.g., mus-) to one of two words differing in stress.
  • Cox, S., Rösler, D., & Skiba, R. (1989). A tailor-made database for language teaching material. Literary & Linguistic Computing, 4(4), 260-264.
  • Cutler, A. (2002). Phonological processing: Comments on Pierrehumbert, Moates et al., Kubozono, Peperkamp & Dupoux, and Bradlow. In C. Gussenhoven, & N. Warner (Eds.), Papers in Laboratory Phonology VII (pp. 275-296). Berlin: Mouton de Gruyter.
  • Cutler, A., & Otake, T. (2002). Rhythmic categories in spoken-word recognition. Journal of Memory and Language, 46(2), 296-322. doi:10.1006/jmla.2001.2814.

    Abstract

    Rhythmic categories such as morae in Japanese or stress units in English play a role in the perception of spoken
    language. We examined this role in Japanese, since recent evidence suggests that morae may intervene as
    structural units in word recognition. First, we found that traditional puns more often substituted part of a mora
    than a whole mora. Second, when listeners reconstructed distorted words, e.g. panorama from panozema, responses
    were faster and more accurate when only a phoneme was distorted (panozama, panorema) than when a
    whole CV mora was distorted (panozema). Third, lexical decisions on the same nonwords were better predicted
    by duration and number of phonemes from nonword uniqueness point to word end than by number of morae. Our
    results indicate no role for morae in early spoken-word processing; we propose that rhythmic categories constrain
    not initial lexical activation but subsequent processes of speech segmentation and selection among word candidates.
  • Cutler, A., & Norris, D. (2002). The role of strong syllables in segmentation for lexical access. In G. T. Altmann (Ed.), Psycholinguistics: Critical concepts in psychology (pp. 157-177). London: Routledge.
  • Cutler, A., Mehler, J., Norris, D., & Segui, J. (2002). The syllable's differing role in the segmentation of French and English. In G. T. Altmann (Ed.), Psycholinguistics: Critical concepts in psychology (pp. 115-135). London: Routledge.

    Abstract

    Speech segmentation procedures may differ in speakers of different languages. Earlier work based on French speakers listening to French words suggested that the syllable functions as a segmentation unit in speech processing. However, while French has relatively regular and clearly bounded syllables, other languages, such as English, do not. No trace of syllabifying segmentation was found in English listeners listening to English words, French words, or nonsense words. French listeners, however, showed evidence of syllabification even when they were listening to English words. We conclude that alternative segmentation routines are available to the human language processor. In some cases speech segmentation may involve the operation of more than one procedure.
  • Cutler, A., McQueen, J. M., Jansonius, M., & Bayerl, S. (2002). The lexical statistics of competitor activation in spoken-word recognition. In C. Bow (Ed.), Proceedings of the 9th Australian International Conference on Speech Science and Technology (pp. 40-45). Canberra: Australian Speech Science and Technology Association (ASSTA).

    Abstract

    The Possible Word Constraint is a proposed mechanism whereby listeners avoid recognising words spuriously embedded in other words. It applies to words leaving a vowelless residue between their edge and the nearest known word or syllable boundary. The present study tests the usefulness of this constraint via lexical statistics of both English and Dutch. The analyses demonstrate that the constraint removes a clear majority of embedded words in speech, and thus can contribute significantly to the efficiency of human speech recognition
  • Cutler, A., Demuth, K., & McQueen, J. M. (2002). Universality versus language-specificity in listening to running speech. Psychological Science, 13(3), 258-262. doi:10.1111/1467-9280.00447.

    Abstract

    Recognizing spoken language involves automatic activation of multiple candidate words. The process of selection between candidates is made more efficient by inhibition of embedded words (like egg in beg) that leave a portion of the input stranded (here, b). Results from European languages suggest that this inhibition occurs when consonants are stranded but not when syllables are stranded. The reason why leftover syllables do not lead to inhibition could be that in principle they might themselves be words; in European languages, a syllable can be a word. In Sesotho (a Bantu language), however, a single syllable cannot be a word. We report that in Sesotho, word recognition is inhibited by stranded consonants, but stranded monosyllables produce no more difficulty than stranded bisyllables (which could be Sesotho words). This finding suggests that the viability constraint which inhibits spurious embedded word candidates is not sensitive to language-specific word structure, but is universal.
  • Cutler, A. (1989). Auditory lexical access: Where do we start? In W. Marslen-Wilson (Ed.), Lexical representation and process (pp. 342-356). Cambridge, MA: MIT Press.

    Abstract

    The lexicon, considered as a component of the process of recognizing speech, is a device that accepts a sound image as input and outputs meaning. Lexical access is the process of formulating an appropriate input and mapping it onto an entry in the lexicon's store of sound images matched with their meanings. This chapter addresses the problems of auditory lexical access from continuous speech. The central argument to be proposed is that utterance prosody plays a crucial role in the access process. Continuous listening faces problems that are not present in visual recognition (reading) or in noncontinuous recognition (understanding isolated words). Aspects of utterance prosody offer a solution to these particular problems.
  • Cutler, A. (1985). Cross-language psycholinguistics. Linguistics, 23, 659-667.
  • Cutler, A. (2002). Lexical access. In L. Nadel (Ed.), Encyclopedia of cognitive science (pp. 858-864). London: Nature Publishing Group.
  • Cutler, A., McQueen, J. M., Norris, D., & Somejuan, A. (2002). Le rôle de la syllable. In E. Dupoux (Ed.), Les langages du cerveau: Textes en l’honneur de Jacques Mehler (pp. 185-197). Paris: Odile Jacob.
  • Cutler, A. (2002). Native listeners. European Review, 10(1), 27-41. doi:10.1017/S1062798702000030.

    Abstract

    Becoming a native listener is the necessary precursor to becoming a native speaker. Babies in the first year of life undertake a remarkable amount of work; by the time they begin to speak, they have perceptually mastered the phonological repertoire and phoneme co-occurrence probabilities of the native language, and they can locate familiar word-forms in novel continuous-speech contexts. The skills acquired at this early stage form a necessary part of adult listening. However, the same native listening skills also underlie problems in listening to a late-acquired non-native language, accounting for why in such a case listening (an innate ability) is sometimes paradoxically more difficult than, for instance, reading (a learned ability).
  • Cutler, A., Howard, D., & Patterson, K. E. (1989). Misplaced stress on prosody: A reply to Black and Byng. Cognitive Neuropsychology, 6, 67-83.

    Abstract

    The recent claim by Black and Byng (1986) that lexical access in reading is subject to prosodic constraints is examined and found to be unsupported. The evidence from impaired reading which Black and Byng report is based on poorly controlled stimulus materials and is inadequately analysed and reported. An alternative explanation of their findings is proposed, and new data are reported for which this alternative explanation can account but their model cannot. Finally, their proposal is shown to be theoretically unmotivated and in conflict with evidence from normal reading.
  • Cutler, A., & Butterfield, S. (1989). Natural speech cues to word segmentation under difficult listening conditions. In J. Tubach, & J. Mariani (Eds.), Proceedings of Eurospeech 89: European Conference on Speech Communication and Technology: Vol. 2 (pp. 372-375). Edinburgh: CEP Consultants.

    Abstract

    One of a listener's major tasks in understanding continuous speech is segmenting the speech signal into separate words. When listening conditions are difficult, speakers can help listeners by deliberately speaking more clearly. In three experiments, we examined how word boundaries are produced in deliberately clear speech. We found that speakers do indeed attempt to mark word boundaries; moreover, they differentiate between word boundaries in a way which suggests they are sensitive to listener needs. Application of heuristic segmentation strategies makes word boundaries before strong syllables easiest for listeners to perceive; but under difficult listening conditions speakers pay more attention to marking word boundaries before weak syllables, i.e. they mark those boundaries which are otherwise particularly hard to perceive.
  • Cutler, A., & Pearson, M. (1985). On the analysis of prosodic turn-taking cues. In C. Johns-Lewis (Ed.), Intonation in discourse (pp. 139-155). London: Croom Helm.
  • Cutler, A. (1985). Performance measures of lexical complexity. In G. Hoppenbrouwers, P. A. Seuren, & A. Weijters (Eds.), Meaning and the lexicon (pp. 75). Dordrecht: Foris.
  • Cutler, A. (1975). Sentence stress and sentence comprehension. PhD Thesis, University of Texas, Austin.
  • Cutler, A. (1989). Straw modules [Commentary/Massaro: Speech perception]. Behavioral and Brain Sciences, 12, 760-762.
  • Cutler, A. (1989). The new Victorians. New Scientist, (1663), 66.
  • Cutler, A., Hawkins, J. A., & Gilligan, G. (1985). The suffixing preference: A processing explanation. Linguistics, 23, 723-758.
  • Cutler, A., & Fay, D. (1975). You have a Dictionary in your Head, not a Thesaurus. Texas Linguistic Forum, 1, 27-40.
  • Dahan, D., Tanenhaus, M. K., & Chambers, C. G. (2002). Accent and reference resolution in spoken-language comprehension. Journal of Memory and Language, 47(2), 292-314. doi:10.1016/S0749-596X(02)00001-3.

    Abstract

    The role of accent in reference resolution was investigated by monitoring eye fixations to lexical competitors (e.g., candy and candle ) as participants followed prerecorded instructions to move objects above or below fixed geometric shapes using a computer mouse. In Experiment 1, the first utterance instructed participants to move one object above or below a shape (e.g., “Put the candle/candy below the triangle”) and the second utterance contained an accented or deaccented definite noun phrase which referred to the same object or introduced a new entity (e.g., “Now put the CANDLE above the square” vs. “Now put the candle ABOVE THE SQUARE”). Fixations to the competitor (e.g., candy ) demonstrated a bias to interpret deaccented nouns as anaphoric and accented nouns as nonanaphoric. Experiment 2 used only accented nouns in the second instruction, varying whether the referent of this second instruction was the Theme of the first instruction (e.g., “Put the candle below the triangle”) or the Goal of the first instruction (e.g., “Put the necklace below the candle”). Participants preferred to interpret accented noun phrases as referring to a previously mentioned nonfocused entity (the Goal) rather than as introducing a new unmentioned entity.
  • Den Os, E., & Boves, L. (2002). BabelWeb project develops multilingual guidelines. Multilingual Computing and Technologies, 13(1), 33-36.

    Abstract

    European cooperative effort seeks best practices architecture and procedures for international sites
  • Deutsch, W., & Frauenfelder, U. (1985). Max-Planck-Institute for Psycholinguistics: Annual Report Nr.6 1985. Nijmegen: MPI for Psycholinguistics.
  • Dimroth, C. (2002). Topics, assertions and additive words: How L2 learners get from information structure to target-language syntax. Linguistics, 40(4), 891-923. doi:10.1515/ling.2002.033.

    Abstract

    The article compares the integration of topic-related additive words at different stages of untutored L2 acquisition. Data stem from an ‘‘additive-elicitation task’’ that was designed in order to capture topic-related additive words in a context that is at the same time controlled for the underlying information structure and nondeviant from other kinds of narrative discourse. We relate the distinction between stressed and nonstressed forms of the German scope particles and adverbials auch ‘also’, noch ‘another’, wieder ‘again’, and immer noch ‘still’ to a uniform, information-structure-based principle: the stressed variants have scope over the topic information of the relevant utterances. It is then the common function of these additive words to express the additive link between the topic of the present utterance and some previous topic for which the same state of affairs is claimed to hold. This phenomenon has often been referred to as ‘‘contrastive topic,’’ but contrary to what this term suggests, these topic elements are by no means deviant from the default in coherent discourse. In the underlying information structure, the validity of some given state of affairs for the present topic must be under discussion. Topic-related additive words then express that the state of affairs indeed applies to this topic, their function therefore coming close to the function of assertion marking. While this functional correspondence goes along with the formal organization of the basic stages of untutored second-language acquisition, its expression brings linguistic constraints into conflict when the acquisition of finiteness pushes learners to reorganize their utterances according to target-language syntax.
  • Dimroth, C., & Lasser, I. (Eds.). (2002). Finite options: How L1 and L2 learners cope with the acquisition of finiteness [Special Issue]. Linguistics, 40(4).
  • Dimroth, C., & Lasser, I. (2002). Finite options: How L1 and L2 learners cope with the acquisition of finiteness. Linguistics, 40(4), 647-651. doi:10.1515/ling.2002.027.
  • Dittmar, N., & Klein, W. (1975). Untersuchungen zum Pidgin-Deutsch spanischer und italienischer Arbeiter in der Bundesrepublik: Ein Arbeitsbericht. In A. Wierlacher (Ed.), Jahrbuch Deutsch als Fremdsprache (pp. 170-194). Heidelberg: Groos.
  • Drolet, M., & Kempen, G. (1985). IPG: A cognitive approach to sentence generation. CCAI: The Journal for the Integrated Study of Artificial Intelligence, Cognitive Science and Applied Epistemology, 2, 37-61.
  • Drude, S. (2002). Fala masculina e feminina em Awetí. In A. D. Rodrigues, & A. S. A. C. Cabral (Eds.), Línguas indígenas Brasileiras: Fonologia, gramática e história. (Atas do I Encontro Internacional do Grupo de Trabalho sobre Línguas Indígenas da ANPOLL). vol. 1 (pp. 177-190). Belém: EDUFPA.
  • Dunn, M., Reesink, G., & Terrill, A. (2002). The East Papuan languages: A preliminary typological appraisal. Oceanic Linguistics, 41(1), 28-62.

    Abstract

    This paper examines the Papuan languages of Island Melanesia, with a view to considering their typological similarities and differences. The East Papuan languages are thought to be the descendants of the languages spoken by the original inhabitants of Island Melanesia, who arrived in the area up to 50,000 years ago. The Oceanic Austronesian languages are thought to have come into the area with the Lapita peoples 3,500 years ago. With this historical backdrop in view, our paper seeks to investigate the linguistic relationships between the scattered Papuan languages of Island Melanesia. To do this, we survey various structural features, including syntactic patterns such as constituent order in clauses and noun phrases and other features of clause structure, paradigmatic structures of pronouns, and the structure of verbal morphology. In particular, we seek to discern similarities between the languages that might call for closer investigation, with a view to establishing genetic relatedness between some or all of the languages. In addition, in examining structural relationships between languages, we aim to discover whether it is possible to distinguish between original Papuan elements and diffused Austronesian elements of these languages. As this is a vast task, our paper aims merely to lay the groundwork for investigation into these and related questions.
  • Enard, W., Przeworski, M., Fisher, S. E., Lai, C. S. L., Wiebe, V., Kitano, T., Pääbo, S., & Monaco, A. P. (2002). Molecular evolution of FOXP2, a gene involved in speech and language [Letters to Nature]. Nature, 418, 869-872. doi:10.1038/nature01025.

    Abstract

    Language is a uniquely human trait likely to have been a prerequisite for the development of human culture. The ability to develop articulate speech relies on capabilities, such as fine control of the larynx and mouth, that are absent in chimpanzees and other great apes. FOXP2 is the first gene relevant to the human ability to develop language. A point mutation in FOXP2 co-segregates with a disorder in a family in which half of the members have severe articulation difficulties accompanied by linguistic and grammatical impairment. This gene is disrupted by translocation in an unrelated individual who has a similar disorder. Thus, two functional copies of FOXP2 seem to be required for acquisition of normal spoken language. We sequenced the complementary DNAs that encode the FOXP2 protein in the chimpanzee, gorilla, orang-utan, rhesus macaque and mouse, and compared them with the human cDNA. We also investigated intraspecific variation of the human FOXP2 gene. Here we show that human FOXP2 contains changes in amino-acid coding and a pattern of nucleotide polymorphism, which strongly suggest that this gene has been the target of selection during recent human evolution.
  • Enfield, N. J. (2002). Semantic analysis of body parts in emotion terminology: Avoiding the exoticisms of 'obstinate monosemy' and 'online extension'. Pragmatics and Cognition, 10(1), 85-106. doi:10.1075/pc.10.12.05enf.

    Abstract

    Investigation of the emotions entails reference to words and expressions conventionally used for the description of emotion experience. Important methodological issues arise for emotion researchers, and the issues are of similarly central concern in linguistic semantics more generally. I argue that superficial and/or inconsistent description of linguistic meaning can have seriously misleading results. This paper is firstly a critique of standards in emotion research for its tendency to underrate and ill-understand linguistic semantics. It is secondly a critique of standards in some approaches to linguistic semantics itself. Two major problems occur. The first is failure to distinguish between conceptually distinct meanings of single words, neglecting the well-established fact that a single phonological string can signify more than one conceptual category (i.e., that words can be polysemous). The second error involves failure to distinguish between two kinds of secondary uses of words: (1) those which are truly active “online” extensions, and (2) those which are conventionalised secondary meanings and not active (qua “extensions”) at all. These semantic considerations are crucial to conclusions one may draw about cognition and conceptualisation based on linguistic evidence.
  • Enfield, N. J. (2002). Semantics and combinatorics of 'sit', 'stand', and 'lie' in Lao. In J. Newman (Ed.), The linguistics of sitting, standing, and lying (pp. 25-41). Amsterdam: Benjamins.
  • Enfield, N. J. (2002). Parallel innovation and 'coincidence' in linguistic areas: On a bi-clausal extent/result constructions of mainland Southeast Asia. In P. Chew (Ed.), Proceedings of the 28th meeting of the Berkeley Linguistics Society. Special session on Tibeto-Burman and Southeast Asian linguistics (pp. 121-128). Berkeley: Berkeley Linguistics Society.
  • Enfield, N. J. (2002). Body 2002. In S. Kita (Ed.), 2002 Supplement (version 3) for the “Manual” for the field season 2001 (pp. 19-32). Nijmegen: Max Planck Institute for Psycholinguistics.
  • Enfield, N. J. (2002). “Fish trap” task. In S. Kita (Ed.), 2002 Supplement (version 3) for the “Manual” for the field season 2001 (pp. 61). Nijmegen: Max Planck Institute for Psycholinguistics.
  • Enfield, N. J. (2002). Cultural logic and syntactic productivity: Associated posture constructions in Lao. In N. Enfield (Ed.), Ethnosyntax: Explorations in culture and grammar (pp. 231-258). Oxford: Oxford University Press.
  • Enfield, N. J. (2002). Ethnosyntax: Introduction. In N. Enfield (Ed.), Ethnosyntax: Explorations in culture and grammar (pp. 1-30). Oxford: Oxford University Press.
  • Enfield, N. J. (2002). Combinatoric properties of natural semantic metalanguage expressions in Lao. In C. Goddard, & A. Wierzbicka (Eds.), Meaning and universal grammar: Theory and empirical findings (pp. 145-256). Amsterdam: John Benjamins.
  • Enfield, N. J. (2002). Functions of 'give' and 'take' in Lao complex predicates. In R. S. Bauer (Ed.), Collected papers on Southeast Asian and Pacific languages (pp. 13-36). Canberra: Pacific Linguistics.
  • Enfield, N. J. (2002). How to define 'Lao', 'Thai', and 'Isan' language? A view from linguistic science. Tai Culture, 7(1), 62-67.

    Abstract

    This article argues that it is not possible to establish distinctions between 'Lao', 'Thai', and 'Isan' as seperate languages or dialects by appealing to objective criteria. 'Lao', 'Thai', and 'Isan' are conceived linguistics varieties, and the ground-level reality reveals a great deal of variation, much of it not coinciding with the geographical boundaries of the 'Laos', 'Isan', and 'non-Isan Thailand' areas. Those who promote 'Lao', 'Thai', and/or 'Isan' as distinct linguistic varieties have subjective (e.g. political and/or sentimental) reasons for doing so. Objective linguistic criteria are not sufficient
  • Enfield, N. J., & Wierzbicka, A. (2002). Introduction: The body in description of emotion. Pragmatics and Cognition, 10(1), 1-24. doi:10.1075/pc.10.12.02enf.

    Abstract

    Anthropologists and linguists have long been aware that the body is explicitly referred to in conventional description of emotion in languages around the world. There is abundant linguistic data showing expression of emotions in terms of their imagined ‘locus’ in the physical body. The most important methodological issue in the study of emotions is language, for the ways people talk give us access to ‘folk descriptions’ of the emotions. ‘Technical terminology’, whether based on English or otherwise, is not excluded from this ‘folk’ status. It may appear to be safely ‘scientific’ and thus culturally neutral, but in fact it is not: technical English is a variety of English and reflects, to some extent, culture-specific ways of thinking (and categorising) associated with the English language. People — as researchers studying other people, or as people in real-life social association — cannot directly access the emotional experience of others, and language is the usual mode of ‘packaging’ one’s experience so it may be accessible to others. Careful description of linguistic data from as broad as possible a cross-linguistic base is thus an important part of emotion research. All people experience biological events and processes associated with certain thoughts (or, as psychologists say, ‘appraisals’), but there is more to ‘emotion’ than just these physiological phenomena. Speakers of some languages talk about their emotional experiences as if they are located in some internal organ such as ‘the liver’, yet they cannot localise feeling in this physical organ. This phenomenon needs to be understood better, and one of the problems is finding a method of comparison that allows us to compare descriptions from different languages which show apparently great formal and semantic variation. Some simple concepts including feel and body are universal or near-universal, and as such are good candidates for terms of description which may help to eradicate confusion and exoticism from cross-linguistic comparison and semantic typology. Semantic analysis reveals great variation in concepts of emotion across languages and cultures — but such analysis requires a sound and well-founded methodology. While leaving room for different approaches to the task, we suggest that such a methodology can be based on empirically established linguistic universal (or near-universal) concepts, and on ‘cognitive scenarios’ articulated in terms of these concepts. Also, we warn against the danger of exoticism involved in taking all body part references ‘literally’. Above all, we argue that what is needed is a combination of empirical cross-linguistic investigations and a theoretical and methodological awareness, recognising the impossibility of exploring other people’s emotions without keeping language in focus: both as an object and as a tool of study.
  • Ernestus, M., Baayen, R. H., & Schreuder, R. (2002). The recognition of reduced word forms. Brain and Language, 81(1-3), 162-173. doi:10.1006/brln.2001.2514.

    Abstract

    This article addresses the recognition of reduced word forms, which are frequent in casual speech. We describe two experiments on Dutch showing that listeners only recognize highly reduced forms well when these forms are presented in their full context and that the probability that a listener recognizes a word form in limited context is strongly correlated with the degree of reduction of the form. Moreover, we show that the effect of degree of reduction can only partly be interpreted as the effect of the intelligibility of the acoustic signal, which is negatively correlated with degree of reduction. We discuss the consequences of our findings for models of spoken word recognition and especially for the role that storage plays in these models.
  • Faller, M. (2002). Remarks on evidential hierarchies. In D. I. Beaver, L. D. C. Martinez, B. Z. Clark., & S. Kaufmann (Eds.), The construction of meaning (pp. 89-111). Stanford: CSLI Publications.
  • Faller, M. (2002). The evidential and validational licensing conditions for the Cusco Quechua enclitic-mi. Belgian Journal of Linguistics, 16, 7-21. doi:10.1075/bjl.16.02fa.
  • Fisher, S. E., Francks, C., McCracken, J. T., McGough, J. J., Marlow, A. J., MacPhie, I. L., Newbury, D. F., Crawford, L. R., Palmer, C. G. S., Woodward, J. A., Del’Homme, M., Cantwell, D. P., Nelson, S. F., Monaco, A. P., & Smalley, S. L. (2002). A genomewide scan for loci involved in Attention-Deficit/Hyperactivity Disorder. American Journal of Human Genetics, 70(5), 1183-1196. doi:10.1086/340112.

    Abstract

    Attention deficit/hyperactivity disorder (ADHD) is a common heritable disorder with a childhood onset. Molecular genetic studies of ADHD have previously focused on examining the roles of specific candidate genes, primarily those involved in dopaminergic pathways. We have performed the first systematic genomewide linkage scan for loci influencing ADHD in 126 affected sib pairs, using a ∼10-cM grid of microsatellite markers. Allele-sharing linkage methods enabled us to exclude any loci with a λs of ⩾3 from 96% of the genome and those with a λs of ⩾2.5 from 91%, indicating that there is unlikely to be a major gene involved in ADHD susceptibility in our sample. Under a strict diagnostic scheme we could exclude all screened regions of the X chromosome for a locus-specific λs of ⩾2 in brother-brother pairs, demonstrating that the excess of affected males with ADHD is probably not attributable to a major X-linked effect. Qualitative trait maximum LOD score analyses pointed to a number of chromosomal sites that may contain genetic risk factors of moderate effect. None exceeded genomewide significance thresholds, but LOD scores were >1.5 for regions on 5p12, 10q26, 12q23, and 16p13. Quantitative-trait analysis of ADHD symptom counts implicated a region on 12p13 (maximum LOD 2.6) that also yielded a LOD >1 when qualitative methods were used. A survey of regions containing 36 genes that have been proposed as candidates for ADHD indicated that 29 of these genes, including DRD4 and DAT1, could be excluded for a λs of 2. Only three of the candidates—DRD5, 5HTT, and CALCYON—coincided with sites of positive linkage identified by our screen. Two of the regions highlighted in the present study, 2q24 and 16p13, coincided with the top linkage peaks reported by a recent genome-scan study of autistic sib pairs.
  • Fisher, S. E., & DeFries, J. C. (2002). Developmental dyslexia: Genetic dissection of a complex cognitive trait. Nature Reviews Neuroscience, 3, 767-780. doi:10.1038/nrn936.

    Abstract

    Developmental dyslexia, a specific impairment of reading ability despite adequate intelligence and educational opportunity, is one of the most frequent childhood disorders. Since the first documented cases at the beginning of the last century, it has become increasingly apparent that the reading problems of people with dyslexia form part of a heritable neurobiological syndrome. As for most cognitive and behavioural traits, phenotypic definition is fraught with difficulties and the genetic basis is complex, making the isolation of genetic risk factors a formidable challenge. Against such a background, it is notable that several recent studies have reported the localization of genes that influence dyslexia and other language-related traits. These investigations exploit novel research approaches that are relevant to many areas of human neurogenetics.
  • Fisher, S. E., Francks, C., Marlow, A. J., MacPhie, I. L., Newbury, D. F., Cardon, L. R., Ishikawa-Brush, Y., Richardson, A. J., Talcott, J. B., Gayán, J., Olson, R. K., Pennington, B. F., Smith, S. D., DeFries, J. C., Stein, J. F., & Monaco, A. P. (2002). Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia. Nature Genetics, 30(1), 86-91. doi:10.1038/ng792.

    Abstract

    Developmental dyslexia is defined as a specific and significant impairment in reading ability that cannot be explained by deficits in intelligence, learning opportunity, motivation or sensory acuity. It is one of the most frequently diagnosed disorders in childhood, representing a major educational and social problem. It is well established that dyslexia is a significantly heritable trait with a neurobiological basis. The etiological mechanisms remain elusive, however, despite being the focus of intensive multidisciplinary research. All attempts to map quantitative-trait loci (QTLs) influencing dyslexia susceptibility have targeted specific chromosomal regions, so that inferences regarding genetic etiology have been made on the basis of very limited information. Here we present the first two complete QTL-based genome-wide scans for this trait, in large samples of families from the United Kingdom and United States. Using single-point analysis, linkage to marker D18S53 was independently identified as being one of the most significant results of the genome in each scan (P< or =0.0004 for single word-reading ability in each family sample). Multipoint analysis gave increased evidence of 18p11.2 linkage for single-word reading, yielding top empirical P values of 0.00001 (UK) and 0.0004 (US). Measures related to phonological and orthographic processing also showed linkage at this locus. We replicated linkage to 18p11.2 in a third independent sample of families (from the UK), in which the strongest evidence came from a phoneme-awareness measure (most significant P value=0.00004). A combined analysis of all UK families confirmed that this newly discovered 18p QTL is probably a general risk factor for dyslexia, influencing several reading-related processes. This is the first report of QTL-based genome-wide scanning for a human cognitive trait.
  • Fisher, S. E. (2002). Isolation of the genetic factors underlying speech and language disorders. In R. Plomin, J. C. DeFries, I. W. Craig, & P. McGuffin (Eds.), Behavioral genetics in the postgenomic era (pp. 205-226). Washington, DC: American Psychological Association.

    Abstract

    This chapter highlights the research in isolating genetic factors underlying specific language impairment (SLI), or developmental dysphasia, which exploits newly developed genotyping technology, novel statistical methodology, and DNA sequence data generated by the Human Genome Project. The author begins with an overview of results from family, twin, and adoption studies supporting genetic involvement and then goes on to outline progress in a number of genetic mapping efforts that have been recently completed or are currently under way. It has been possible for genetic researchers to pinpoint the specific mutation responsible for some speech and language disorders, providing an example of how the availability of human genomic sequence data can greatly accelerate the pace of disease gene discovery. Finally, the author discusses future prospects on how molecular genetics may offer new insight into the etiology underlying speech and language disorders, leading to improvements in diagnosis and treatment.
  • Francks, C., Fisher, S. E., MacPhie, I. L., Richardson, A. J., Marlow, A. J., Stein, J. F., & Monaco, A. P. (2002). A genomewide linkage screen for relative hand skill in sibling pairs. American Journal of Human Genetics, 70(3), 800-805. doi:10.1086/339249.

    Abstract

    Genomewide quantitative-trait locus (QTL) linkage analysis was performed using a continuous measure of relative hand skill (PegQ) in a sample of 195 reading-disabled sibling pairs from the United Kingdom. This was the first genomewide screen for any measure related to handedness. The mean PegQ in the sample was equivalent to that of normative data, and PegQ was not correlated with tests of reading ability (correlations between −0.13 and 0.05). Relative hand skill could therefore be considered normal within the sample. A QTL on chromosome 2p11.2-12 yielded strong evidence for linkage to PegQ (empirical P=.00007), and another suggestive QTL on 17p11-q23 was also identified (empirical P=.002). The 2p11.2-12 locus was further analyzed in an independent sample of 143 reading-disabled sibling pairs, and this analysis yielded an empirical P=.13. Relative hand skill therefore is probably a complex multifactorial phenotype with a heterogeneous background, but nevertheless is amenable to QTL-based gene-mapping approaches.
  • Francks, C., Fisher, S. E., Olson, R. K., Pennington, B. F., Smith, S. D., DeFries, J. C., & Monaco, A. P. (2002). Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: Quantitative association analysis and positional candidate genes SEMA4F and OTX1. Psychiatric Genetics, 12(1), 35-41.

    Abstract

    A locus on chromosome 2p12-16 has been implicated in dyslexia susceptibility by two independent linkage studies, including our own study of 119 nuclear twin-based families, each with at least one reading-disabled child. Nonetheless, no variant of any gene has been reported to show association with dyslexia, and no consistent clinical evidence exists to identify candidate genes with any strong a priori logic. We used 21 microsatellite markers spanning 2p12-16 to refine our 1-LOD unit linkage support interval to 12cM between D2S337 and D2S286. Then, in quantitative association analysis, two microsatellites yielded P values<0.05 across a range of reading-related measures (D2S2378 and D2S2114). The exon/intron borders of two positional candidate genes within the region were characterized, and the exons were screened for polymorphisms. The genes were Semaphorin4F (SEMA4F), which encodes a protein involved in axonal growth cone guidance, and OTX1, encoding a homeodomain transcription factor involved in forebrain development. Two non-synonymous single nucleotide polymorphisms were found in SEMA4F, each with a heterozygosity of 0.03. One intronic single nucleotide polymorphism between exons 12 and 13 of SEMA4F was tested for quantitative association, but no significant association was found. Only one single nucleotide polymorphism was found in OTX1, which was exonic but silent. Our data therefore suggest that linkage with reading disability at 2p12-16 is not caused by coding variants of SEMA4F or OTX1. Our study outlines the approach necessary for the identification of genetic variants causing dyslexia susceptibility in an epidemiological population of dyslexics.
  • Francks, C., MacPhie, I. L., & Monaco, A. P. (2002). The genetic basis of dyslexia. The Lancet Neurology, 1(8), 483-490. doi:10.1016/S1474-4422(02)00221-1.

    Abstract

    Dyslexia, a disorder of reading and spelling, is a heterogeneous neurological syndrome with a complex genetic and environmental aetiology. People with dyslexia differ in their individual profiles across a range of cognitive, physiological, and behavioural measures related to reading disability. Some or all of the subtypes of dyslexia might have partly or wholly distinct genetic causes. An understanding of the role of genetics in dyslexia could help to diagnose and treat susceptible children more effectively and rapidly than is currently possible and in ways that account for their individual disabilities. This knowledge will also give new insights into the neurobiology of reading and language cognition. Genetic linkage analysis has identified regions of the genome that might harbour inherited variants that cause reading disability. In particular, loci on chromosomes 6 and 18 have shown strong and replicable effects on reading abilities. These genomic regions contain tens or hundreds of candidate genes, and studies aimed at the identification of the specific causal genetic variants are underway.
  • Fransson, P., Merboldt, K.-D., Petersson, K. M., Ingvar, M., & Frahm, J. (2002). On the effects of spatial filtering — A comparative fMRI study of episodic memory encoding at high and low resolution. NeuroImage, 16(4), 977-984. doi:10.1006/nimg.2002.1079.

    Abstract

    Theeffects of spatial filtering in functional magnetic resonance imaging were investigated by reevaluating the data of a previous study of episodic memory encoding at 2 × 2 × 4-mm3 resolution with use of a SPM99 analysis involving a Gaussian kernel of 8-mm full width at half maximum. In addition, a multisubject analysis of activated regions was performed by normalizing the functional images to an approximate Talairach brain atlas. In individual subjects, spatial filtering merged activations in anatomically separated brain regions. Moreover, small foci of activated pixels which originated from veins became blurred and hence indistinguishable from parenchymal responses. The multisubject analysis resulted in activation of the hippocampus proper, a finding which could not be confirmed by the activation maps obtained at high resolution. It is concluded that the validity of multisubject fMRI analyses can be considerably improved by first analyzing individual data sets at optimum resolution to assess the effects of spatial filtering and minimize the risk of signal contamination by macroscopically visible vessels.

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