Publications

Displaying 401 - 418 of 418
  • Verkerk, A. (2014). The correlation between motion event encoding and path verb lexicon size in the Indo-European language family. Folia Linguistica Historica, 35, 307-358. doi:10.1515/flih.2014.009.

    Abstract

    There have been opposing views on the possibility of a relationship between motion event encoding and the size of the path verb lexicon. Özçalışkan (2004) has proposed that verb-framed and satellite-framed languages should approximately have the same number of path verbs, whereas a review of some of the literature suggests that verb-framed languages typically have a bigger path verb lexicon than satelliteframed languages. In this article I demonstrate that evidence for this correlation can be found through phylogenetic comparative analysis of parallel corpus data from twenty Indo-European languages.
  • Vernes, S. C. (2014). Genome wide identification of fruitless targets suggests a role in upregulating genes important for neural circuit formation. Scientific Reports, 4: 4412. doi:10.1038/srep04412.

    Abstract

    The fruitless gene (fru) encodes a set of transcription factors (Fru) that display sexually dimorphic gene expression in the brain of the fruit-fly;Drosophila melanogaster . Behavioural studies have demonstrated that fru isessentialforcourtshipbehaviour inthemale flyandisthoughttoact bydirectingthe development of sex-specific neural circuitry that encodes this innate behavioural response. This study reports the identification of direct regulatory targets of the sexually dimorphic isoforms of the Fru protein using an in vitro model system. Genome wide binding sites were identified for each of the isoforms using Chromatin Immunoprecipitation coupled to deep sequencing (ChIP-Seq). Putative target genes were found to be involved in processes such as neurotransmission, ion-channel signalling and neuron development. All isoforms showed asignificant bias towards genes located on the X-chromosome,which may reflect a specific role for Fru in regulating x-linked genes. Taken together with expression analysis carried out in Fru positive neurons specifically isolated from the male fly brain, it appears that the Fru protein acts as a transcriptional activator. Understanding the regulatory cascades induced by Fru will help to shed light on the molecular mechanisms that are important for specification of neural circuitry underlying complex behaviour
  • De Vos, C. (2014). Absolute spatial deixis and proto-toponyms in Kata Kolok. NUSA: Linguistic studies of languages in and around Indonesia, 56, 3-26.

    Abstract

    This paper presents an overview of spatial deictic structures in Kata Kolok, a sign language which is indigenous to a Balinese village community. Sociolinguistic surveys and lexicographic comparisons have indicated that Kata Kolok is unrelated to the signing varieties in other parts of Bali and should be considered a sign language isolate as such. Kata Kolok emerged five generations ago and has been in intimate contact with spoken Balinese from its incipience. The findings from this paper suggest that this cross-modal contact has led to an absolute construction of the signing space, which is radically different in comparison to spatial deixis in other sign languages. Furthermore, Kata Kolok does not seem to have a class of true toponyms, but rather deploys deictic proto-toponyms. The Kata Kolok system on the whole does not exhibit any related linguistic forms or direct calques from spoken Balinese, and this suggests that the conceptual overlap between these two languages may have been facilitated by shared cultural practices as well as gestural communication rather than direct borrowings. Ultimately, this analysis challenges the very notion of a sign language isolate and suggests that Kata Kolok and other emergent signing varieties should be considered in light of the broader semiotic context in which they have evolved.

    Additional information

    http://hdl.handle.net/11372/VC-1001
  • De Vries, B., Eising, E., Broos, L. A. M., Koelewijn, S. C., Todorov, B., Frants, R. R., Boer, J. M., Ferraro, M. D., Thoen, P. A. C., & Van Den Maagdenberg, A. (2014). RNA expression profiling in brains of familial hemiplegic migraine type 1 knock-in mice. Cephalalgia, 34(3), 174-182. doi:10.1177/0333102413502736.

    Abstract

    Background Various CACNA1A missense mutations cause familial hemiplegic migraine type 1 (FHM1), a rare monogenic subtype of migraine with aura. FHM1 mutation R192Q is associated with pure hemiplegic migraine, whereas the S218L mutation causes hemiplegic migraine, cerebellar ataxia, seizures, and mild head trauma-induced brain edema. Transgenic knock-in (KI) migraine mouse models were generated that carried either the FHM1 R192Q or the S218L mutation and were shown to exhibit increased CaV2.1 channel activity. Here we investigated their cerebellar and caudal cortical transcriptome. Methods Caudal cortical and cerebellar RNA expression profiles from mutant and wild-type mice were studied using microarrays. Respective brain regions were selected based on their relevance to migraine aura and ataxia. Relevant expression changes were further investigated at RNA and protein level by quantitative polymerase chain reaction (qPCR) and/or immunohistochemistry, respectively. Results Expression differences in the cerebellum were most pronounced in S218L mice. Particularly, tyrosine hydroxylase, a marker of delayed cerebellar maturation, appeared strongly upregulated in S218L cerebella. In contrast, only minimal expression differences were observed in the caudal cortex of either mutant mice strain. Conclusion Despite pronounced consequences of migraine gene mutations at the neurobiological level, changes in cortical RNA expression in FHM1 migraine mice compared to wild-type are modest. In contrast, pronounced RNA expression changes are seen in the cerebellum of S218L mice and may explain their cerebellar ataxia phenotype
  • Ward, M. E., McMahon, G., St Pourcain, B., Evans, D. M., Rietveld, C. A., Benjamin, D. J., Koellinger, P. D., Cesarini, D., Smith, G. D., Timpson, N. J., & Consortium}, {. S. G. A. (2014). Genetic variation associated with differential educational attainment in adults has anticipated associations with school performance in children. PLoS ONE, 9(7): e100248. doi:10.1371/journal.pone.0100248.

    Abstract

    Genome-wide association study results have yielded evidence for the association of common genetic variants with crude measures of completed educational attainment in adults. Whilst informative, these results do not inform as to the mechanism of these effects or their presence at earlier ages and where educational performance is more routinely and more precisely assessed. Single nucleotide polymorphisms exhibiting genome-wide significant associations with adult educational attainment were combined to derive an unweighted allele score in 5,979 and 6,145 young participants from the Avon Longitudinal Study of Parents and Children with key stage 3 national curriculum test results (SATS results) available at age 13 to 14 years in English and mathematics respectively. Standardised (z-scored) results for English and mathematics showed an expected relationship with sex, with girls exhibiting an advantage over boys in English (0.433 SD (95%CI 0.395, 0.470), p<10-10) with more similar results (though in the opposite direction) in mathematics (0.042 SD (95%CI 0.004, 0.080), p = 0.030). Each additional adult educational attainment increasing allele was associated with 0.041 SD (95%CI 0.020, 0.063), p = 1.79×10-04 and 0.028 SD (95%CI 0.007, 0.050), p = 0.01 increases in standardised SATS score for English and mathematics respectively. Educational attainment is a complex multifactorial behavioural trait which has not had heritable contributions to it fully characterised. We were able to apply the results from a large study of adult educational attainment to a study of child exam performance marking events in the process of learning rather than realised adult end product. Our results support evidence for common, small genetic contributions to educational attainment, but also emphasise the likely lifecourse nature of this genetic effect. Results here also, by an alternative route, suggest that existing methods for child examination are able to recognise early life variation likely to be related to ultimate educational attainment.
  • Warner, N., McQueen, J. M., & Cutler, A. (2014). Tracking perception of the sounds of English. The Journal of the Acoustical Society of America, 135, 2295-3006. doi:10.1121/1.4870486.

    Abstract

    Twenty American English listeners identified gated fragments of all 2288 possible English within-word and cross-word diphones, providing a total of 538 560 phoneme categorizations. The results show orderly uptake of acoustic information in the signal and provide a view of where information about segments occurs in time. Information locus depends on each speech sound’s identity and phonological features. Affricates and diphthongs have highly localized information so that listeners’ perceptual accuracy rises during a confined time range. Stops and sonorants have more distributed and gradually appearing information. The identity and phonological features (e.g., vowel vs consonant) of the neighboring segment also influences when acoustic information about a segment is available. Stressed vowels are perceived significantly more accurately than unstressed vowels, but this effect is greater for lax vowels than for tense vowels or diphthongs. The dataset charts the availability of perceptual cues to segment identity across time for the full phoneme repertoire of English in all attested phonetic contexts.
  • Weber, A., Di Betta, A. M., & McQueen, J. M. (2014). Treack or trit: Adaptation to genuine and arbitrary foreign accents by monolingual and bilingual listeners. Journal of phonetics, 46, 34-51. doi:10.1016/j.wocn.2014.05.002.

    Abstract

    Two cross-modal priming experiments examined two questions about word recognition in foreign-accented speech: Does accent adaptation occur only for genuine accents markers, and does adaptation depend on language experience? We compared recognition of words spoken with canonical, genuinely-accented and arbitrarily-accented vowels. In Experiment 1, an Italian speaker pronounced vowels in English prime words canonically, or by lengthening /ɪ/ as in a genuine Italian accent (*/tri:k/ for trick), or by arbitrarily shortening /i:/ (*/trɪt/ for treat). Lexical-decision times to subsequent visual target words showed different priming effects in three listener groups. Monolingual native English listeners recognized variants with lengthened but not shortened vowels. Bilingual nonnative Italian-English listeners, who could not reliably distinguish vowel length, recognized both variants. Bilingual nonnative Dutch-English listeners also recognized both variants. In Experiment 2, bilingual Dutch-English listeners recognized Dutch words with genuinely- and arbitrarily-accented vowels (spoken by a native Italian with lengthened and shortened vowels respectively), but recognized words with canonical vowels more easily than words with accented vowels. These results suggest that adaptation to genuine accent markers arises for monolingual and bilingual listeners alike and can occur in native and nonnative languages, but that bilinguals can adapt to arbitrary accent markers better than monolinguals.
  • Wegman, J., Fonteijn, H. M., van Ekert, J., Tyborowska, A., Jansen, C., & Janzen, G. (2014). Gray and white matter correlates of navigational ability in humans. Human Brain Mapping, 35(6), 2561-2572. doi:10.1002/hbm.22349.

    Abstract

    Humans differ widely in their navigational abilities. Studies have shown that self-reports on navigational abilities are good predictors of performance on navigation tasks in real and virtual environments. The caudate nucleus and medial temporal lobe regions have been suggested to subserve different navigational strategies. The ability to use different strategies might underlie navigational ability differences. This study examines the anatomical correlates of self-reported navigational ability in both gray and white matter. Local gray matter volume was compared between a group (N = 134) of good and bad navigators using voxel-based morphometry (VBM), as well as regional volumes. To compare between good and bad navigators, we also measured white matter anatomy using diffusion tensor imaging (DTI) and looked at fractional anisotropy (FA) values. We observed a trend toward higher local GM volume in right anterior parahippocampal/rhinal cortex for good versus bad navigators. Good male navigators showed significantly higher local GM volume in right hippocampus than bad male navigators. Conversely, bad navigators showed increased FA values in the internal capsule, the white matter bundle closest to the caudate nucleus and a trend toward higher local GM volume in the caudate nucleus. Furthermore, caudate nucleus regional volume correlated negatively with navigational ability. These convergent findings across imaging modalities are in line with findings showing that the caudate nucleus and the medial temporal lobes are involved in different wayfinding strategies. Our study is the first to show a link between self-reported large-scale navigational abilities and different measures of brain anatomy.
  • Whitmarsh, S., Barendregt, H., Schoffelen, J.-M., & Jensen, O. (2014). Metacognitive awareness of covert somatosensory attention corresponds to contralateral alpha power. NeuroImage, 85(2), 803-809. doi:10.1016/j.neuroimage.2013.07.031.

    Abstract

    Studies on metacognition have shown that participants can report on their performance on a wide range of perceptual, memory and behavioral tasks. We know little, however, about the ability to report on one's attentional focus. The degree and direction of somatosensory attention can, however, be readily discerned through suppression of alpha band frequencies in EEG/MEG produced by the somatosensory cortex. Such top-down attentional modulations of cortical excitability have been shown to result in better discrimination performance and decreased response times. In this study we asked whether the degree of attentional focus is also accessible for subjective report, and whether such evaluations correspond to the amount of somatosensory alpha activity. In response to auditory cues participants maintained somatosensory attention to either their left or right hand for intervals varying randomly between 5 and 32seconds, while their brain activity was recorded with MEG. Trials were terminated by a probe sound, to which they reported their level of attention on the cued hand right before probe-onset. Using a beamformer approach, we quantified the alpha activity in left and right somatosensory regions, one second before the probe. Alpha activity from contra- and ipsilateral somatosensory cortices for high versus low attention trials were compared. As predicted, the contralateral somatosensory alpha depression correlated with higher reported attentional focus. Finally, alpha activity two to three seconds before the probe-onset was correlated with attentional focus. We conclude that somatosensory attention is indeed accessible to metacognitive awareness.
  • Widlok, T., & Burenhult, N. (2014). Sehen, riechen, orientieren. Spektrum der Wissenschaft, June 2014, 76-81.
  • Willems, R. M., Van der Haegen, L., Fisher, S. E., & Francks, C. (2014). On the other hand: Including left-handers in cognitive neuroscience and neurogenetics. Nature Reviews Neuroscience, 15, 193-201. doi:10.1038/nrn3679.

    Abstract

    Left-handers are often excluded from study cohorts in neuroscience and neurogenetics in order to reduce variance in the data. However, recent investigations have shown that the inclusion or targeted recruitment of left-handers can be informative in studies on a range of topics, such as cerebral lateralization and the genetic underpinning of asymmetrical brain development. Left-handed individuals represent a substantial portion of the human population and therefore left-handedness falls within the normal range of human diversity; thus, it is important to account for this variation in our understanding of brain functioning. We call for neuroscientists and neurogeneticists to recognize the potential of studying this often-discarded group of research subjects.
  • Willems, R. M., & Francks, C. (2014). Your left-handed brain. Frontiers for Young Minds, 2: 13. doi:10.3389/frym.2014.00013.

    Abstract

    While most people prefer to use their right hand to brush their teeth, throw a ball, or hold a tennis racket, left-handers prefer to use their left hand. This is the case for around 10 per cent of all people. There was a time (not so long ago) when left-handers were stigmatized in Western (and other) communities: it was considered a bad sign if you were left-handed, and left-handed children were often forced to write with their right hand. This is nonsensical: there is nothing wrong with being left-handed, and trying to write with the non-preferred hand is frustrating for almost everybody. As a matter of fact, science can learn from left-handers, and in this paper, we discuss how this may be the case. We review why some people are left-handed and others are not, how left-handers' brains differ from right-handers’, and why scientists study left-handedness in the first place
  • Witteman, M. J., Weber, A., & McQueen, J. M. (2014). Tolerance for inconsistency in foreign-accented speech. Psychonomic Bulletin & Review, 21, 512-519. doi:10.3758/s13423-013-0519-8.

    Abstract

    Are listeners able to adapt to a foreign-accented speaker who has, as is often the case, an inconsistent accent? Two groups of native Dutch listeners participated in a cross-modal priming experiment, either in a consistent-accent condition (German-accented items only) or in an inconsistent-accent condition (German-accented and nativelike pronunciations intermixed). The experimental words were identical for both groups (words with vowel substitutions characteristic of German-accented speech); additional contextual words differed in accentedness (German-accented or nativelike words). All items were spoken by the same speaker: a German native who could produce the accented forms but could also pass for a Dutch native speaker. Listeners in the consistent-accent group were able to adapt quickly to the speaker (i.e., showed facilitatory priming for words with vocalic substitutions). Listeners in the inconsistent-accent condition showed adaptation to words with vocalic substitutions only in the second half of the experiment. These results indicate that adaptation to foreign-accented speech is rapid. Accent inconsistency slows listeners down initially, but a short period of additional exposure is enough for them to adapt to the speaker. Listeners can therefore tolerate inconsistency in foreign-accented speech.
  • Wnuk, E., & Burenhult, N. (2014). Contact and isolation in hunter-gatherer language dynamics: Evidence from Maniq phonology (Aslian, Malay Peninsula). Studies in Language, 38(4), 956-981. doi:10.1075/sl.38.4.06wnu.
  • Wnuk, E., & Majid, A. (2014). Revisiting the limits of language: The odor lexicon of Maniq. Cognition, 131, 125-138. doi:10.1016/j.cognition.2013.12.008.

    Abstract

    It is widely believed that human languages cannot encode odors. While this is true for English,
    and other related languages, data from some non-Western languages challenge this
    view. Maniq, a language spoken by a small population of nomadic hunter–gatherers in
    southern Thailand, is such a language. It has a lexicon of over a dozen terms dedicated
    to smell. We examined the semantics of these smell terms in 3 experiments (exemplar
    listing, similarity judgment and off-line rating). The exemplar listing task confirmed that
    Maniq smell terms have complex meanings encoding smell qualities. Analyses of the
    similarity data revealed that the odor lexicon is coherently structured by two dimensions.
    The underlying dimensions are pleasantness and dangerousness, as verified by the off-line
    rating study. Ethnographic data illustrate that smell terms have detailed semantics tapping
    into broader cultural constructs. Contrary to the widespread view that languages cannot
    encode odors, the Maniq data show odor can be a coherent semantic domain, thus shedding
    new light on the limits of language.
  • Yang, Y., Dai, B., Howell, P., Wang, X., Li, K., & Lu, C. (2014). White and Grey Matter Changes in the Language Network during Healthy Aging. PLoS One, 9(9): e108077. doi: 10.1371/journal.pone.0108077.

    Abstract

    Neural structures change with age but there is no consensus on the exact processes involved. This study tested the hypothesis that white and grey matter in the language network changes during aging according to a “last in, first out” process. The fractional anisotropy (FA) of white matter and cortical thickness of grey matter were measured in 36 participants whose ages ranged from 55 to 79 years. Within the language network, the dorsal pathway connecting the mid-to-posterior superior temporal cortex (STC) and the inferior frontal cortex (IFC) was affected more by aging in both FA and thickness than the other dorsal pathway connecting the STC with the premotor cortex and the ventral pathway connecting the mid-to-anterior STC with the ventral IFC. These results were independently validated in a second group of 20 participants whose ages ranged from 50 to 73 years. The pathway that is most affected during aging matures later than the other two pathways (which are present at birth). The results are interpreted as showing that the neural structures which mature later are affected more than those that mature earlier, supporting the “last in, first out” theory.
  • De Zubicaray, G. I., Hartsuiker, R. J., & Acheson, D. J. (2014). Mind what you say—general and specific mechanisms for monitoring in speech production. Frontiers in Human Neuroscience, 8: 514. doi:10.3389%2Ffnhum.2014.00514.

    Abstract

    For most people, speech production is relatively effortless and error-free. Yet it has long been recognized that we need some type of control over what we are currently saying and what we plan to say. Precisely how we monitor our internal and external speech has been a topic of research interest for several decades. The predominant approach in psycholinguistics has assumed monitoring of both is accomplished via systems responsible for comprehending others' speech.

    This special topic aimed to broaden the field, firstly by examining proposals that speech production might also engage more general systems, such as those involved in action monitoring. A second aim was to examine proposals for a production-specific, internal monitor. Both aims require that we also specify the nature of the representations subject to monitoring.
  • Zumer, J. M., Scheeringa, R., Schoffelen, J.-M., Norris, D. G., & Jensen, O. (2014). Occipital alpha activity during stimulus processing gates the information flow to object-selective cortex. PLoS Biology, 12(10): e1001965. doi:10.1371/journal.pbio.1001965.

    Abstract

    Given the limited processing capabilities of the sensory system, it is essential that attended information is gated to downstream areas, whereas unattended information is blocked. While it has been proposed that alpha band (8–13 Hz) activity serves to route information to downstream regions by inhibiting neuronal processing in task-irrelevant regions, this hypothesis remains untested. Here we investigate how neuronal oscillations detected by electroencephalography in visual areas during working memory encoding serve to gate information reflected in the simultaneously recorded blood-oxygenation-level-dependent (BOLD) signals recorded by functional magnetic resonance imaging in downstream ventral regions. We used a paradigm in which 16 participants were presented with faces and landscapes in the right and left hemifields; one hemifield was attended and the other unattended. We observed that decreased alpha power contralateral to the attended object predicted the BOLD signal representing the attended object in ventral object-selective regions. Furthermore, increased alpha power ipsilateral to the attended object predicted a decrease in the BOLD signal representing the unattended object. We also found that the BOLD signal in the dorsal attention network inversely correlated with visual alpha power. This is the first demonstration, to our knowledge, that oscillations in the alpha band are implicated in the gating of information from the visual cortex to the ventral stream, as reflected in the representationally specific BOLD signal. This link of sensory alpha to downstream activity provides a neurophysiological substrate for the mechanism of selective attention during stimulus processing, which not only boosts the attended information but also suppresses distraction. Although previous studies have shown a relation between the BOLD signal from the dorsal attention network and the alpha band at rest, we demonstrate such a relation during a visuospatial task, indicating that the dorsal attention network exercises top-down control of visual alpha activity.

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