Publications

Displaying 1 - 100 of 933
  • Abbott, M. J., Angele, B., Ahn, D., & Rayner, K. (2015). Skipping syntactically illegal the previews: The role of predictability. Journal of Experimental Psychology: Learning, Memory, and Cognition, 41(6), 1703-1714. doi:10.1037/xlm0000142.

    Abstract

    Readers tend to skip words, particularly when they are short, frequent, or predictable. Angele and Rayner (2013) recently reported that readers are often unable to detect syntactic anomalies in parafoveal vision. In the present study, we manipulated target word predictability to assess whether contextual constraint modulates the-skipping behavior. The results provide further evidence that readers frequently skip the article the when infelicitous in context. Readers skipped predictable words more often than unpredictable words, even when the, which was syntactically illegal and unpredictable from the prior context, was presented as a parafoveal preview. The results of the experiment were simulated using E-Z Reader 10 by assuming that cloze probability can be dissociated from parafoveal visual input. It appears that when a short word is predictable in context, a decision to skip it can be made even if the information available parafoveally conflicts both visually and syntactically with those predictions.
  • Ahlsson, F., Åkerud, H., Schijven, D., Olivier, J., & Sundström-Poromaa, I. (2015). Gene expression in placentas from nondiabetic women giving birth to large for gestational age infants. Reproductive Sciences, 22(10), 1281-1288. doi:10.1177/1933719115578928.

    Abstract

    Gestational diabetes, obesity, and excessive weight gain are known independent risk factors for the birth of a large for gestational age (LGA) infant. However, only 1 of the 10 infants born LGA is born by mothers with diabetes or obesity. Thus, the aim of the present study was to compare placental gene expression between healthy, nondiabetic mothers (n = 22) giving birth to LGA infants and body mass index-matched mothers (n = 24) giving birth to appropriate for gestational age infants. In the whole gene expression analysis, only 29 genes were found to be differently expressed in LGA placentas. Top upregulated genes included insulin-like growth factor binding protein 1, aminolevulinate δ synthase 2, and prolactin, whereas top downregulated genes comprised leptin, gametocyte-specific factor 1, and collagen type XVII α 1. Two enriched gene networks were identified, namely, (1) lipid metabolism, small molecule biochemistry, and organismal development and (2) cellular development, cellular growth, proliferation, and tumor morphology.
  • Ahluwalia, T. S., Prins, B. P., Abdollahi, M., Armstrong, N. J., Aslibekyan, S., Bain, L., Jefferis, B., Baumert, J., Beekman, M., Ben-Shlomo, Y., Bis, J. C., Mitchell, B. D., De Geus, E., Delgado, G. E., Marek, D., Eriksson, J., Kajantie, E., Kanoni, S., Kemp, J. P., Lu, C. and 106 moreAhluwalia, T. S., Prins, B. P., Abdollahi, M., Armstrong, N. J., Aslibekyan, S., Bain, L., Jefferis, B., Baumert, J., Beekman, M., Ben-Shlomo, Y., Bis, J. C., Mitchell, B. D., De Geus, E., Delgado, G. E., Marek, D., Eriksson, J., Kajantie, E., Kanoni, S., Kemp, J. P., Lu, C., Marioni, R. E., McLachlan, S., Milaneschi, Y., Nolte, I. M., Petrelis, A. M., Porcu, E., Sabater-Lleal, M., Naderi, E., Seppälä, I., Shah, T., Singhal, G., Standl, M., Teumer, A., Thalamuthu, A., Thiering, E., Trompet, S., Ballantyne, C. M., Benjamin, E. J., Casas, J. P., Toben, C., Dedoussis, G., Deelen, J., Durda, P., Engmann, J., Feitosa, M. F., Grallert, H., Hammarstedt, A., Harris, S. E., Homuth, G., Hottenga, J.-J., Jalkanen, S., Jamshidi, Y., Jawahar, M. C., Jess, T., Kivimaki, M., Kleber, M. E., Lahti, J., Liu, Y., Marques-Vidal, P., Mellström, D., Mooijaart, S. P., Müller-Nurasyid, M., Penninx, B., Revez, J. A., Rossing, P., Räikkönen, K., Sattar, N., Scharnagl, H., Sennblad, B., Silveira, A., St Pourcain, B., Timpson, N. J., Trollor, J., CHARGE Inflammation Working Group, Van Dongen, J., Van Heemst, D., Visvikis-Siest, S., Vollenweider, P., Völker, U., Waldenberger, M., Willemsen, G., Zabaneh, D., Morris, R. W., Arnett, D. K., Baune, B. T., Boomsma, D. I., Chang, Y.-P.-C., Deary, I. J., Deloukas, P., Eriksson, J. G., Evans, D. M., Ferreira, M. A., Gaunt, T., Gudnason, V., Hamsten, A., Heinrich, J., Hingorani, A., Humphries, S. E., Jukema, J. W., Koenig, W., Kumari, M., Kutalik, Z., Lawlor, D. A., Lehtimäki, T., März, W., Mather, K. A., Naitza, S., Nauck, M., Ohlsson, C., Price, J. F., Raitakari, O., Rice, K., Sachdev, P. S., Slagboom, E., Sørensen, T. I. A., Spector, T., Stacey, D., Stathopoulou, M. G., Tanaka, T., Wannamethee, S. G., Whincup, P., Rotter, J. I., Dehghan, A., Boerwinkle, E., Psaty, B. M., Snieder, H., & Alizadeh, B. Z. (2021). Genome-wide association study of circulating interleukin 6 levels identifies novel loci. Human Molecular Genetics, 5(1), 393-409. doi:10.1093/hmg/ddab023.

    Abstract

    Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (Pcombined = 1.8 × 10−11), HLA-DRB1/DRB5 rs660895 on Chr6p21 (Pcombined = 1.5 × 10−10) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (Pcombined = 1.2 × 10−122). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.
  • Ahn, D., Ferreira, V. S., & Gollan, T. H. (2021). Selective activation of language specific structural representations: Evidence from extended picture-word interference. Journal of Memory and Language, 120: 104249. doi:10.1016/j.jml.2021.104249.

    Abstract

    How do bilingual speakers represent and use information that guides the assembly of the words into phrases and sentences (i.e., sentence structures) for languages that have different word orders? Cross-language syntactic priming effects provide mixed evidence on whether bilinguals access sentence structures from both languages even when speaking just one. Here, we compared English monolinguals, Korean-immersed Korean-English bilinguals, and English-immersed Korean-English bilinguals while they produced noun phrases (“the lemon below the lobster”), which have different word orders in English and Korean (the Korean translation word order is [lobster][below][lemon]). We examined when speakers plan each noun using an extended picture-word interference paradigm, by measuring articulation times for each word in the phrase with either the distractor word “apple” (which slows the planning of “lemon”) or “crab” (which slows the planning of “lobster”). Results suggest that for phrases that are different in linear word order across languages, bilinguals only access the sentence structure of the one language they are actively speaking at the time, even when switching languages between trials.
  • Alday, P. M. (2015). Be Careful When Assuming the Obvious: Commentary on “The Placement of the Head that Minimizes Online Memory: A Complex Systems Approach”. Language Dynamics and Change, 5(1), 138-146. doi:10.1163/22105832-00501008.

    Abstract

    Ferrer-i-Cancho (this volume) presents a mathematical model of both the synchronic and diachronic nature of word order based on the assumption that memory costs are a never decreasing function of distance and a few very general linguistic assumptions. However, even these minimal and seemingly obvious assumptions are not as safe as they appear in light of recent typological and psycholinguistic evidence. The interaction of word order and memory has further depths to be explored.
  • Alday, P. M., Schlesewsky, M., & Bornkessel-Schlesewsky, I. (2015). Discovering prominence and its role in language processing: An individual (differences) approach. Linguistics Vanguard, 1(1), 201-213. doi:10.1515/lingvan-2014-1013.

    Abstract

    It has been suggested that, during real time language comprehension, the human language processing system attempts to identify the argument primarily responsible for the state of affairs (the “actor”) as quickly and unambiguously as possible. However, previous work on a prominence (e.g. animacy, definiteness, case marking) based heuristic for actor identification has suffered from underspecification of the relationship between different cue hierarchies. Qualitative work has yielded a partial ordering of many features (e.g. MacWhinney et al. 1984), but a precise quantification has remained elusive due to difficulties in exploring the full feature space in a particular language. Feature pairs tend to correlate strongly in individual languages for semantic-pragmatic reasons (e.g., animate arguments tend to be actors and actors tend to be morphosyntactically privileged), and it is thus difficult to create acceptable stimuli for a fully factorial design even for binary features. Moreover, the exponential function grows extremely rapidly and a fully crossed factorial design covering the entire feature space would be prohibitively long for a purely within-subjects design. Here, we demonstrate the feasibility of parameter estimation in a short experiment. We are able to estimate parameters at a single subject level for the parameters animacy, case and number. This opens the door for research into individual differences and population variation. Moreover, the framework we introduce here can be used in the field to measure more “exotic” languages and populations, even with small sample sizes. Finally, pooled single-subject results are used to reduce the number of free parameters in previous work based on the extended Argument Dependency Model (Bornkessel-Schlesewsky and Schlesewsky 2006, 2009, 2013, in press; Alday et al. 2014).
  • Alday, P. M. (2019). How much baseline correction do we need in ERP research? Extended GLM model can replace baseline correction while lifting its limits. Psychophysiology, 56(12): e13451. doi:10.1111/psyp.13451.

    Abstract

    Baseline correction plays an important role in past and current methodological debates in ERP research (e.g., the Tanner vs. Maess debate in the Journal of Neuroscience Methods), serving as a potential alternative to strong high‐pass filtering. However, the very assumptions that underlie traditional baseline also undermine it, implying a reduction in the signal‐to‐noise ratio. In other words, traditional baseline correction is statistically unnecessary and even undesirable. Including the baseline interval as a predictor in a GLM‐based statistical approach allows the data to determine how much baseline correction is needed, including both full traditional and no baseline correction as special cases. This reduces the amount of variance in the residual error term and thus has the potential to increase statistical power.
  • Alday, P. M. (2019). M/EEG analysis of naturalistic stories: a review from speech to language processing. Language, Cognition and Neuroscience, 34(4), 457-473. doi:10.1080/23273798.2018.1546882.

    Abstract

    M/EEG research using naturally spoken stories as stimuli has focused largely on speech and not
    language processing. The temporal resolution of M/EEG is a two-edged sword, allowing for the
    study of the fine acoustic structure of speech, yet easily overwhelmed by the temporal noise of
    variation in constituent length. Recent theories on the neural encoding of linguistic structure
    require the temporal resolution of M/EEG, yet suffer from confounds when studied on traditional,
    heavily controlled stimuli. Recent methodological advances allow for synthesising naturalistic
    designs and traditional, controlled designs into effective M/EEG research on naturalistic
    language. In this review, we highlight common threads throughout the at-times distinct research
    traditions of speech and language processing. We conclude by examining the tradeoffs and
    successes of three M/EEG studies on fully naturalistic language paradigms and the future
    directions they suggest.
  • Alday, P. M., & Kretzschmar, F. (2019). Speed-accuracy tradeoffs in brain and behavior: Testing the independence of P300 and N400 related processes in behavioral responses to sentence categorization. Frontiers in Human Neuroscience, 13: 285. doi:10.3389/fnhum.2019.00285.

    Abstract

    Although the N400 was originally discovered in a paradigm designed to elicit a P300 (Kutas and Hillyard, 1980), its relationship with the P300 and how both overlapping event-related potentials (ERPs) determine behavioral profiles is still elusive. Here we conducted an ERP (N = 20) and a multiple-response speed-accuracy tradeoff (SAT) experiment (N = 16) on distinct participant samples using an antonym paradigm (The opposite of black is white/nice/yellow with acceptability judgment). We hypothesized that SAT profiles incorporate processes of task-related decision-making (P300) and stimulus-related expectation violation (N400). We replicated previous ERP results (Roehm et al., 2007): in the correct condition (white), the expected target elicits a P300, while both expectation violations engender an N400 [reduced for related (yellow) vs. unrelated targets (nice)]. Using multivariate Bayesian mixed-effects models, we modeled the P300 and N400 responses simultaneously and found that correlation between residuals and subject-level random effects of each response window was minimal, suggesting that the components are largely independent. For the SAT data, we found that antonyms and unrelated targets had a similar slope (rate of increase in accuracy over time) and an asymptote at ceiling, while related targets showed both a lower slope and a lower asymptote, reaching only approximately 80% accuracy. Using a GLMM-based approach (Davidson and Martin, 2013), we modeled these dynamics using response time and condition as predictors. Replacing the predictor for condition with the averaged P300 and N400 amplitudes from the ERP experiment, we achieved identical model performance. We then examined the piecewise contribution of the P300 and N400 amplitudes with partial effects (see Hohenstein and Kliegl, 2015). Unsurprisingly, the P300 amplitude was the strongest contributor to the SAT-curve in the antonym condition and the N400 was the strongest contributor in the unrelated condition. In brief, this is the first demonstration of how overlapping ERP responses in one sample of participants predict behavioral SAT profiles of another sample. The P300 and N400 reflect two independent but interacting processes and the competition between these processes is reflected differently in behavioral parameters of speed and accuracy.

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  • Alhama, R. G., & Zuidema, W. (2019). A review of computational models of basic rule learning: The neural-symbolic debate and beyond. Psychonomic Bulletin & Review, 26(4), 1174-1194. doi:10.3758/s13423-019-01602-z.

    Abstract

    We present a critical review of computational models of generalization of simple grammar-like rules, such as ABA and ABB. In particular, we focus on models attempting to account for the empirical results of Marcus et al. (Science, 283(5398), 77–80 1999). In that study, evidence is reported of generalization behavior by 7-month-old infants, using an Artificial Language Learning paradigm. The authors fail to replicate this behavior in neural network simulations, and claim that this failure reveals inherent limitations of a whole class of neural networks: those that do not incorporate symbolic operations. A great number of computational models were proposed in follow-up studies, fuelling a heated debate about what is required for a model to generalize. Twenty years later, this debate is still not settled. In this paper, we review a large number of the proposed models. We present a critical analysis of those models, in terms of how they contribute to answer the most relevant questions raised by the experiment. After identifying which aspects require further research, we propose a list of desiderata for advancing our understanding on generalization.
  • Ambridge, B., Kidd, E., Rowland, C. F., & Theakston, A. L. (2015). Authors' response [The ubiquity of frequency effects in first language acquisition]. Journal of Child Language, 42(2), 316-322. doi:10.1017/S0305000914000841.

    Abstract

    Our target paper argued for the ubiquity of frequency effects in acquisition, and that any comprehensive theory must take into account the multiplicity of ways that frequently occurring and co-occurring linguistic units affect the acquisition process. The commentaries on the paper provide a largely unanimous endorsement of this position, but raise additional issues likely to frame further discussion and theoretical development. Specifically, while most commentators did not deny the importance of frequency effects, all saw this as the tip of the theoretical iceberg. In this short response we discuss common themes raised in the commentaries, focusing on the broader issue of what frequency effects mean for language acquisition.

    Additional information

    Target paper
  • Ambridge, B., Bidgood, A., Twomey, K. E., Pine, J. M., Rowland, C. F., & Freudenthal, D. (2015). Preemption versus Entrenchment: Towards a Construction-General Solution to the Problem of the Retreat from Verb Argument Structure Overgeneralization. PLoS One, 10(4): e0123723. doi:10.1371/journal.pone.0123723.

    Abstract

    Participants aged 5;2-6;8, 9;2-10;6 and 18;1-22;2 (72 at each age) rated verb argument structure overgeneralization errors (e.g., *Daddy giggled the baby) using a five-point scale. The study was designed to investigate the feasibility of two proposed construction-general solutions to the question of how children retreat from, or avoid, such errors. No support was found for the prediction of the preemption hypothesis that the greater the frequency of the verb in the single most nearly synonymous construction (for this example, the periphrastic causative; e.g., Daddy made the baby giggle), the lower the acceptability of the error. Support was found, however, for the prediction of the entrenchment hypothesis that the greater the overall frequency of the verb, regardless of construction, the lower the acceptability of the error, at least for the two older groups. Thus while entrenchment appears to be a robust solution to the problem of the retreat from error, and one that generalizes across different error types, we did not find evidence that this is the case for preemption. The implication is that the solution to the retreat from error lies not with specialized mechanisms, but rather in a probabilistic process of construction competition.
  • Ambridge, B., Kidd, E., Rowland, C. F., & Theakston, A. L. (2015). The ubiquity of frequency effects in first language acquisition. Journal of Child Language, 42(2), 239-273. doi:10.1017/S030500091400049X.

    Abstract

    This review article presents evidence for the claim that frequency effects are pervasive in children's first language acquisition, and hence constitute a phenomenon that any successful account must explain. The article is organized around four key domains of research: children's acquisition of single words, inflectional morphology, simple syntactic constructions, and more advanced constructions. In presenting this evidence, we develop five theses. (i) There exist different types of frequency effect, from effects at the level of concrete lexical strings to effects at the level of abstract cues to thematic-role assignment, as well as effects of both token and type, and absolute and relative, frequency. High-frequency forms are (ii) early acquired and (iii) prevent errors in contexts where they are the target, but also (iv) cause errors in contexts in which a competing lower-frequency form is the target. (v) Frequency effects interact with other factors (e.g. serial position, utterance length), and the patterning of these interactions is generally informative with regard to the nature of the learning mechanism. We conclude by arguing that any successful account of language acquisition, from whatever theoretical standpoint, must be frequency sensitive to the extent that it can explain the effects documented in this review, and outline some types of account that do and do not meet this criterion.

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  • Ameka, F. K. (1995). The linguistic construction of space in Ewe. Cognitive Linguistics, 6(2/3), 139-182. doi:10.1515/cogl.1995.6.2-3.139.

    Abstract

    This paper presents the linguistic means of describing spatial relations in Ewe with particular emphasis on the grammar and meaning of adpositions. Ewe ( N iger-Congo ) has two sets of adpositions: prepositions, which have evolvedfrom verbs, and postpositions which have evolvedfrom nouns. The postpositions create places and are treated äs intrinsic parts or regions of the reference object in a spatial description. The prepositions provide the general orientation of a Figure (located object). It is demonstrated (hat spaiial relations, such äs those encapsulated in "the basic topological prepositions at, in and on" in English (Herskovits 1986: 9), are not encoded in single linguistic elements in Ewe, but are distributed over members of dijferent form classes in a syntagmatic string, The paper explores the r öle of compositionality andits interaction with pragmatics to yield understandings of spatial configurations in such a language where spatial meanings cannot he simply read off one form. The study also examines the diversity among languages in terms of the nature and obligatoriness of the coding of relational and ground Information in spatial constructions. It is argued that the ränge and type of distinctions discussed in the paper must be accountedfor in semantic typology and in the cross-linguistic investigation of spatial language and conceptualisation.
  • Araújo, S., Huettig, F., & Meyer, A. S. (2021). What underlies the deficit in rapid automatized naming (RAN) in adults with dyslexia? Evidence from eye movements. Scientific Studies of Reading, 25(6), 534-549. doi:10.1080/10888438.2020.1867863.

    Abstract

    This eye-tracking study explored how phonological encoding and speech production planning for successive words are coordinated in adult readers with dyslexia (N = 22) and control readers (N = 25) during rapid automatized naming (RAN). Using an object-RAN task, we orthogonally manipulated the word-form frequency and phonological neighborhood density of the object names and assessed the effects on speech and eye movements and their temporal coordination. In both groups, there was a significant interaction between word frequency and neighborhood density: shorter fixations for dense than for sparse neighborhoods were observed for low-, but not for high-frequency words. This finding does not suggest a specific difficulty in lexical phonological access in dyslexia. However, in readers with dyslexia only, these lexical effects percolated to the late processing stages, indicated by longer offset eye-speech lags. We close by discussing potential reasons for this finding, including suboptimal specification of phonological representations and deficits in attention control or in multi-item coordination.
  • Araújo, S., Fernandes, T., & Huettig, F. (2019). Learning to read facilitates retrieval of phonological representations in rapid automatized naming: Evidence from unschooled illiterate, ex-illiterate, and schooled literate adults. Developmental Science, 22(4): e12783. doi:10.1111/desc.12783.

    Abstract

    Rapid automatized naming (RAN) of visual items is a powerful predictor of reading skills. However, the direction and locus of the association between RAN and reading is still largely unclear. Here we investigated whether literacy acquisition directly bolsters RAN efficiency for objects, adopting a strong methodological design, by testing three groups of adults matched in age and socioeconomic variables, who differed only in literacy/schooling: unschooled illiterate and ex-illiterate, and schooled literate adults. To investigate in a fine-grained manner whether and how literacy facilitates lexical retrieval, we orthogonally manipulated the word-form frequency (high vs. low) and phonological neighborhood density (dense vs. spare) of the objects’ names. We observed that literacy experience enhances the automaticity with which visual stimuli (e.g., objects) can be retrieved and named: relative to readers (ex-illiterate and literate), illiterate adults performed worse on RAN. Crucially, the group difference was exacerbated and significant only for those items that were of low frequency and from sparse neighborhoods. These results thus suggest that, regardless of schooling and age at which literacy was acquired, learning to read facilitates the access to and retrieval of phonological representations, especially of difficult lexical items.
  • Araújo, S., Faísca, L., Bramão, I., Reis, A., & Petersson, K. M. (2015). Lexical and sublexical orthographic processing: An ERP study with skilled and dyslexic adult readers. Brain and Language, 141, 16-27. doi:10.1016/j.bandl.2014.11.007.

    Abstract

    This ERP study investigated the cognitive nature of the P1–N1 components during orthographic processing. We used an implicit reading task with various types of stimuli involving different amounts of sublexical or lexical orthographic processing (words, pseudohomophones, pseudowords, nonwords, and symbols), and tested average and dyslexic readers. An orthographic regularity effect (pseudowords– nonwords contrast) was observed in the average but not in the dyslexic group. This suggests an early sensitivity to the dependencies among letters in word-forms that reflect orthographic structure, while the dyslexic brain apparently fails to be appropriately sensitive to these complex features. Moreover, in the adults the N1-response may already reflect lexical access: (i) the N1 was sensitive to the familiar vs. less familiar orthographic sequence contrast; (ii) and early effects of the phonological form (words-pseudohomophones contrast) were also found. Finally, the later N320 component was attenuated in the dyslexics, suggesting suboptimal processing in later stages of phonological analysis.
  • Araújo, S., Reis, A., Petersson, K. M., & Faísca, L. (2015). Rapid automatized naming and reading performance: A meta-analysis. Journal of Educational Psychology, 107(3), 868-883. doi:10.1037/edu0000006.

    Abstract

    Evidence that rapid naming skill is associated with reading ability has become increasingly prevalent in recent years. However, there is considerable variation in the literature concerning the magnitude of this relationship. The objective of the present study was to provide a comprehensive analysis of the evidence on the relationship between rapid automatized naming (RAN) and reading performance. To this end, we conducted a meta-analysis of the correlational relationship between these 2 constructs to (a) determine the overall strength of the RAN–reading association and (b) identify variables that systematically moderate this relationship. A random-effects model analysis of data from 137 studies (857 effect sizes; 28,826 participants) indicated a moderate-to-strong relationship between RAN and reading performance (r = .43, I2 = 68.40). Further analyses revealed that RAN contributes to the 4 measures of reading (word reading, text reading, non-word reading, and reading comprehension), but higher coefficients emerged in favor of real word reading and text reading. RAN stimulus type and type of reading score were the factors with the greatest moderator effect on the magnitude of the RAN–reading relationship. The consistency of orthography and the subjects’ grade level were also found to impact this relationship, although the effect was contingent on reading outcome. It was less evident whether the subjects’ reading proficiency played a role in the relationship. Implications for future studies are discussed.
  • Armeni, K., Willems, R. M., Van den Bosch, A., & Schoffelen, J.-M. (2019). Frequency-specific brain dynamics related to prediction during language comprehension. NeuroImage, 198, 283-295. doi:10.1016/j.neuroimage.2019.04.083.

    Abstract

    The brain's remarkable capacity to process spoken language virtually in real time requires fast and efficient information processing machinery. In this study, we investigated how frequency-specific brain dynamics relate to models of probabilistic language prediction during auditory narrative comprehension. We recorded MEG activity while participants were listening to auditory stories in Dutch. Using trigram statistical language models, we estimated for every word in a story its conditional probability of occurrence. On the basis of word probabilities, we computed how unexpected the current word is given its context (word perplexity) and how (un)predictable the current linguistic context is (word entropy). We then evaluated whether source-reconstructed MEG oscillations at different frequency bands are modulated as a function of these language processing metrics. We show that theta-band source dynamics are increased in high relative to low entropy states, likely reflecting lexical computations. Beta-band dynamics are increased in situations of low word entropy and perplexity possibly reflecting maintenance of ongoing cognitive context. These findings lend support to the idea that the brain engages in the active generation and evaluation of predicted language based on the statistical properties of the input signal.

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  • Arunkumar, M., Van Paridon, J., Ostarek, M., & Huettig, F. (2021). Do illiterates have illusions? A conceptual (non)replication of Luria (1976). Journal of Cultural Cognitive Science, 5, 143-158. doi:10.1007/s41809-021-00080-x.

    Abstract

    Luria (1976) famously observed that people who never learnt to read and write do not perceive visual illusions. We conducted a conceptual replication of the Luria study of the effect of literacy on the processing of visual illusions. We designed two carefully controlled experiments with 161 participants with varying literacy levels ranging from complete illiterates to high literates in Chennai, India. Accuracy and reaction time in the identification of two types of visual shape and color illusions and the identification of appropriate control images were measured. Separate statistical analyses of Experiments 1 and 2 as well as pooled analyses of both experiments do not provide any support for the notion that literacy effects the perception of visual illusions. Our large sample, carefully controlled study strongly suggests that literacy does not meaningfully affect the identification of visual illusions and raises some questions about other reports about cultural effects on illusion perception.
  • Asaridou, S. S., Hagoort, P., & McQueen, J. M. (2015). Effects of early bilingual experience with a tone and a non-tone language on speech-music. PLoS One, 10(12): e0144225. doi:10.1371/journal.pone.0144225.

    Abstract

    We investigated music and language processing in a group of early bilinguals who spoke a tone language and a non-tone language (Cantonese and Dutch). We assessed online speech-music processing interactions, that is, interactions that occur when speech and music are processed simultaneously in songs, with a speeded classification task. In this task, participants judged sung pseudowords either musically (based on the direction of the musical interval) or phonologically (based on the identity of the sung vowel). We also assessed longer-term effects of linguistic experience on musical ability, that is, the influence of extensive prior experience with language when processing music. These effects were assessed with a task in which participants had to learn to identify musical intervals and with four pitch-perception tasks. Our hypothesis was that due to their experience in two different languages using lexical versus intonational tone, the early Cantonese-Dutch bilinguals would outperform the Dutch control participants. In online processing, the Cantonese-Dutch bilinguals processed speech and music more holistically than controls. This effect seems to be driven by experience with a tone language, in which integration of segmental and pitch information is fundamental. Regarding longer-term effects of linguistic experience, we found no evidence for a bilingual advantage in either the music-interval learning task or the pitch-perception tasks. Together, these results suggest that being a Cantonese-Dutch bilingual does not have any measurable longer-term effects on pitch and music processing, but does have consequences for how speech and music are processed jointly.

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  • Athanasopoulos, P., Bylund, E., Montero-Melis, G., Damjanovic, L., Schartner, A., Kibbe, A., Riches, N., & Thierry, G. (2015). Two languages, two minds: Flexible cognitive processing driven by language of operation. Psychological Science, 26(4), 518-526. doi:10.1177/0956797614567509.

    Abstract

    People make sense of objects and events around them by classifying them into identifiable categories. The extent to which language affects this process has been the focus of a long-standing debate: Do different languages cause their speakers to behave differently? Here, we show that fluent German-English bilinguals categorize motion events according to the grammatical constraints of the language in which they operate. First, as predicted from cross-linguistic differences in motion encoding, bilingual participants functioning in a German testing context prefer to match events on the basis of motion completion to a greater extent than do bilingual participants in an English context. Second, when bilingual participants experience verbal interference in English, their categorization behavior is congruent with that predicted for German; when bilingual participants experience verbal interference in German, their categorization becomes congruent with that predicted for English. These findings show that language effects on cognition are context-bound and transient, revealing unprecedented levels of malleability in human cognition.

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  • Azar, Z., & Ozyurek, A. (2015). Discourse Management: Reference tracking in speech and gesture in Turkish narratives. Dutch Journal of Applied Linguistics, 4(2), 222-240. doi:10.1075/dujal.4.2.06aza.

    Abstract

    Speakers achieve coherence in discourse by alternating between differential lexical forms e.g. noun phrase, pronoun, and null form in accordance with the accessibility of the entities they refer to, i.e. whether they introduce an entity into discourse for the first time or continue referring to an entity they already mentioned before. Moreover, tracking of entities in discourse is a multimodal phenomenon. Studies show that speakers are sensitive to the informational structure of discourse and use fuller forms (e.g. full noun phrases) in speech and gesture more when re-introducing an entity while they use attenuated forms (e.g. pronouns) in speech and gesture less when maintaining a referent. However, those studies focus mainly on non-pro-drop languages (e.g. English, German and French). The present study investigates whether the same pattern holds for pro-drop languages. It draws data from adult native speakers of Turkish using elicited narratives. We find that Turkish speakers mostly use fuller forms to code subject referents in re-introduction context and the null form in maintenance context and they point to gesture space for referents more in re-introduction context compared maintained context. Hence we provide supportive evidence for the reverse correlation between the accessibility of a discourse referent and its coding in speech and gesture. We also find that, as a novel contribution, third person pronoun is used in re-introduction context only when the referent was previously mentioned as the object argument of the immediately preceding clause.
  • Azar, Z., Backus, A., & Ozyurek, A. (2019). General and language specific factors influence reference tracking in speech and gesture in discourse. Discourse Processes, 56(7), 553-574. doi:10.1080/0163853X.2018.1519368.

    Abstract

    Referent accessibility influences expressions in speech and gestures in similar ways. Speakers mostly use richer forms as noun phrases (NPs) in speech and gesture more when referents have low accessibility, whereas they use reduced forms such as pronouns more often and gesture less when referents have high accessibility. We investigated the relationships between speech and gesture during reference tracking in a pro-drop language—Turkish. Overt pronouns were not strongly associated with accessibility but with pragmatic context (i.e., marking similarity, contrast). Nevertheless, speakers gestured more when referents were re-introduced versus maintained and when referents were expressed with NPs versus pronouns. Pragmatic context did not influence gestures. Further, pronouns in low-accessibility contexts were accompanied with gestures—possibly for reference disambiguation—more often than previously found for non-pro-drop languages in such contexts. These findings enhance our understanding of the relationships between speech and gesture at the discourse level.
  • Baayen, H., & Lieber, R. (1991). Productivity and English derivation: A corpus-based study. Linguistics, 29(5), 801-843. doi:10.1515/ling.1991.29.5.801.

    Abstract

    The notion of productivity is one which is central to the study of morphology.
    It is a notion about which linguists frequently have intuitions. But it is a notion which still
    remains somewhat problematic in the
    literature on generative morphology some
    15 years after Aronoff raised the issue in his (1976) monograph. In this paper we will review some of the definitions and measures of productivity discussed in the generative and pregenerative literature.
    We will adopt the definition of productivity suggested by Schultink (1961) and propose
    a number of statistical measures of productivity whose results, when
    applied to a fixed corpus, accord nicely with our intuitive estimates of productivity, and which shed light on the quantitative weight of linguistic restrictions on word formation rules. Part of our
    purpose here is also a very
    simple one: to make
    available a substantial
    set of empirical data concerning
    the productivity of
    some of the major derivational
    affixes of English.

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  • Baggio, G., van Lambalgen, M., & Hagoort, P. (2015). Logic as Marr's computational level: Four case studies. Topics in Cognitive Science, 7, 287-298. doi:10.1111/tops.12125.

    Abstract

    We sketch four applications of Marr's levels-of-analysis methodology to the relations between logic and experimental data in the cognitive neuroscience of language and reasoning. The first part of the paper illustrates the explanatory power of computational level theories based on logic. We show that a Bayesian treatment of the suppression task in reasoning with conditionals is ruled out by EEG data, supporting instead an analysis based on defeasible logic. Further, we describe how results from an EEG study on temporal prepositions can be reanalyzed using formal semantics, addressing a potential confound. The second part of the article demonstrates the predictive power of logical theories drawing on EEG data on processing progressive constructions and on behavioral data on conditional reasoning in people with autism. Logical theories can constrain processing hypotheses all the way down to neurophysiology, and conversely neuroscience data can guide the selection of alternative computational level models of cognition.
  • Bakker, I., Takashima, A., Van Hall, J. G., & McQueen, J. M. (2015). Changes in theta and beta oscillations as signatures of novel word consolidation. Journal of cognitive neuroscience, 27(7), 1286-1297. doi:10.1162/jocn_a_00801.

    Abstract

    The complementary learning systems account of word learning states that novel words, like other types of memories, undergo an offline consolidation process during which they are gradually integrated into the neocortical memory network. A fundamental change in the neural representation of a novel word should therefore occur in the hours after learning. The present EEG study tested this hypothesis by investigating whether novel words learned before a 24-hr consolidation period elicited more word-like oscillatory responses than novel words learned immediately before testing. In line with previous studies indicating that theta synchronization reflects lexical access, unfamiliar novel words elicited lower power in the theta band (4–8 Hz) than existing words. Recently learned words still showed a marginally lower theta increase than existing words, but theta responses to novel words that had been acquired 24 hr earlier were indistinguishable from responses to existing words. Consistent with evidence that beta desynchronization (16–21 Hz) is related to lexical-semantic processing, we found that both unfamiliar and recently learned novel words elicited less beta desynchronization than existing words. In contrast, no difference was found between novel words learned 24 hr earlier and existing words. These data therefore suggest that an offline consolidation period enables novel words to acquire lexically integrated, word-like neural representations.
  • Bakker, I., Takashima, A., van Hell, J. G., Janzen, G., & McQueen, J. M. (2015). Tracking lexical consolidation with ERPs: Lexical and semantic-priming effects on N400 and LPC responses to newly-learned words. Neuropsychologia, 79, 33-41. doi:10.1016/j.neuropsychologia.2015.10.020.
  • Bakker-Marshall, I., Takashima, A., Fernandez, C. B., Janzen, G., McQueen, J. M., & Van Hell, J. G. (2021). Overlapping and distinct neural networks supporting novel word learning in bilinguals and monolinguals. Bilingualism: Language and Cognition, 24(3), 524-536. doi:10.1017/S1366728920000589.

    Abstract

    This study investigated how bilingual experience alters neural mechanisms supporting novel word learning. We hypothesised that novel words elicit increased semantic activation in the larger bilingual lexicon, potentially stimulating stronger memory integration than in monolinguals. English monolinguals and Spanish–English bilinguals were trained on two sets of written Swahili–English word pairs, one set on each of two consecutive days, and performed a recognition task in the MRI-scanner. Lexical integration was measured through visual primed lexical decision. Surprisingly, no group difference emerged in explicit word memory, and priming occurred only in the monolingual group. This difference in lexical integration may indicate an increased need for slow neocortical interleaving of old and new information in the denser bilingual lexicon. The fMRI data were consistent with increased use of cognitive control networks in monolinguals and of articulatory motor processes in bilinguals, providing further evidence for experience-induced neural changes: monolinguals and bilinguals reached largely comparable behavioural performance levels in novel word learning, but did so by recruiting partially overlapping but non-identical neural systems to acquire novel words.
  • Balakrishnan, B., Verheijen, J., Lupo, A., Raymond, K., Turgeon, C., Yang, Y., Carter, K. L., Whitehead, K. J., Kozicz, T., Morava, E., & Lai, K. (2019). A novel phosphoglucomutase-deficient mouse model reveals aberrant glycosylation and early embryonic lethality. Journal of Inherited Metabolic Disease, 42(5), 998-1007. doi:10.1002/jimd.12110.

    Abstract

    Patients with phosphoglucomutase (PGM1) deficiency, a congenital disorder of glycosylation (CDG) suffer from multiple disease phenotypes. Midline cleft defects are present at birth. Overtime, additional clinical phenotypes, which include severe hypoglycemia, hepatopathy, growth retardation, hormonal deficiencies, hemostatic anomalies, frequently lethal, early-onset of dilated cardiomyopathy and myopathy emerge, reflecting the central roles of the enzyme in (glycogen) metabolism and glycosylation. To delineate the pathophysiology of the tissue-specific disease phenotypes, we constructed a constitutive Pgm2 (mouse ortholog of human PGM1)-knockout (KO) mouse model using CRISPR-Cas9 technology. After multiple crosses between heterozygous parents, we were unable to identify homozygous life births in 78 newborn pups (P = 1.59897E-06), suggesting an embryonic lethality phenotype in the homozygotes. Ultrasound studies of the course of pregnancy confirmed Pgm2-deficient pups succumb before E9.5. Oral galactose supplementation (9 mg/mL drinking water) did not rescue the lethality. Biochemical studies of tissues and skin fibroblasts harvested from heterozygous animals confirmed reduced Pgm2 enzyme activity and abundance, but no change in glycogen content. However, glycomics analyses in serum revealed an abnormal glycosylation pattern in the Pgm2(+/-) animals, similar to that seen in PGM1-CDG.
  • Bank, R., Crasborn, O., & Van Hout, R. (2015). Alignment of two languages: The spreading of mouthings in Sign Language of the Netherlands. International Journal of Bilingualism, 19, 40-55. doi:10.1177/1367006913484991.

    Abstract

    Mouthings and mouth gestures are omnipresent in Sign Language of the Netherlands (NGT). Mouthings in NGT are mouth actions that have their origin in spoken Dutch, and are usually time aligned with the signs they co-occur with. Frequently, however, they spread over one or more adjacent signs, so that one mouthing co-occurs with multiple manual signs. We conducted a corpus study to explore how frequently this occurs in NGT and whether there is any sociolinguistic variation in the use of spreading. Further, we looked at the circumstances under which spreading occurs. Answers to these questions may give us insight into the prosodic structure of sign languages. We investigated a sample of the Corpus NGT containing 5929 mouthings by 46 participants. We found that spreading over an adjacent sign is independent of social factors. Further, mouthings that spread are longer than non-spreading mouthings, whether measured in syllables or in milliseconds. By using a relatively large amount of natural data, we succeeded in gaining more insight into the way mouth actions are utilised in sign languages
  • Baranova, J. (2015). Other-initiated repair in Russian. Open linguistics, 1(1), 555-577. doi:10.1515/opli-2015-0019.

    Abstract

    This article describes the interactional patterns and linguistic structures associated with otherinitiated repair, as observed in a corpus of video-recorded conversations in Russian. In the discussion of various repair cases special attention is given to the modifications that the trouble source turn undergoes in response to an open versus a restricted repair initiation. Speakers often modify their problematic turn in multiple ways at ones when responding to an open repair initiation. They can alter the word order of the problematic turn, change prosodic contour of the utterance, omit redundant elements and add more specific ones. By contrast, restricted repair initiations usually receive specific repair solutions that target only one problem at a time
  • Barendse, M. T., Oort, F. J., & Timmerman, M. E. (2015). Using exploratory factor analysis to determine the dimensionality of discrete responses. Structural Equation Modeling: A Multidisciplinary Journal, 22(1), 87-101. doi:10.1080/10705511.2014.934850.

    Abstract

    Exploratory factor analysis (EFA) is commonly used to determine the dimensionality of continuous data. In a simulation study we investigate its usefulness with discrete data. We vary response scales (continuous, dichotomous, polytomous), factor loadings (medium, high), sample size (small, large), and factor structure (simple, complex). For each condition, we generate 1,000 data sets and apply EFA with 5 estimation methods (maximum likelihood [ML] of covariances, ML of polychoric correlations, robust ML, weighted least squares [WLS], and robust WLS) and 3 fit criteria (chi-square test, root mean square error of approximation, and root mean square residual). The various EFA procedures recover more factors when sample size is large, factor loadings are high, factor structure is simple, and response scales have more options. Robust WLS of polychoric correlations is the preferred method, as it is theoretically justified and shows fewer convergence problems than the other estimation methods.
  • Barlas, P., Kyriakou, K., Guest, O., Kleanthous, S., & Otterbacher, J. (2021). To "see" is to stereotype: Image tagging algorithms, gender recognition, and the accuracy-fairness trade-off. Proceedings of the ACM on Human Computer Interaction, 4(CSCW3): 32. doi:10.1145/3432931.

    Abstract

    Machine-learned computer vision algorithms for tagging images are increasingly used by developers and researchers, having become popularized as easy-to-use "cognitive services." Yet these tools struggle with gender recognition, particularly when processing images of women, people of color and non-binary individuals. Socio-technical researchers have cited data bias as a key problem; training datasets often over-represent images of people and contexts that convey social stereotypes. The social psychology literature explains that people learn social stereotypes, in part, by observing others in particular roles and contexts, and can inadvertently learn to associate gender with scenes, occupations and activities. Thus, we study the extent to which image tagging algorithms mimic this phenomenon. We design a controlled experiment, to examine the interdependence between algorithmic recognition of context and the depicted person's gender. In the spirit of auditing to understand machine behaviors, we create a highly controlled dataset of people images, imposed on gender-stereotyped backgrounds. Our methodology is reproducible and our code publicly available. Evaluating five proprietary algorithms, we find that in three, gender inference is hindered when a background is introduced. Of the two that "see" both backgrounds and gender, it is the one whose output is most consistent with human stereotyping processes that is superior in recognizing gender. We discuss the accuracy--fairness trade-off, as well as the importance of auditing black boxes in better understanding this double-edged sword.
  • Barthel, M., & Sauppe, S. (2019). Speech planning at turn transitions in dialogue is associated with increased processing load. Cognitive Science, 43(7): e12768. doi:10.1111/cogs.12768.

    Abstract

    Speech planning is a sophisticated process. In dialog, it regularly starts in overlap with an incoming turn by a conversation partner. We show that planning spoken responses in overlap with incoming turns is associated with higher processing load than planning in silence. In a dialogic experiment, participants took turns with a confederate describing lists of objects. The confederate’s utterances (to which participants responded) were pre‐recorded and varied in whether they ended in a verb or an object noun and whether this ending was predictable or not. We found that response planning in overlap with sentence‐final verbs evokes larger task‐evoked pupillary responses, while end predictability had no effect. This finding indicates that planning in overlap leads to higher processing load for next speakers in dialog and that next speakers do not proactively modulate the time course of their response planning based on their predictions of turn endings. The turn‐taking system exerts pressure on the language processing system by pushing speakers to plan in overlap despite the ensuing increase in processing load.
  • Bartolozzi, F., Jongman, S. R., & Meyer, A. S. (2021). Concurrent speech planning does not eliminate repetition priming from spoken words: Evidence from linguistic dual-tasking. Journal of Experimental Psychology: Learning, Memory, and Cognition, 47(3), 466-480. doi:10.1037/xlm0000944.

    Abstract

    In conversation, production and comprehension processes may overlap, causing interference. In 3 experiments, we investigated whether repetition priming can work as a supporting device, reducing costs associated with linguistic dual-tasking. Experiment 1 established the rate of decay of repetition priming from spoken words to picture naming for primes embedded in sentences. Experiments 2 and 3 investigated whether the rate of decay was faster when participants comprehended the prime while planning to name unrelated pictures. In all experiments, the primed picture followed the sentences featuring the prime on the same trial, or 10 or 50 trials later. The results of the 3 experiments were strikingly similar: robust repetition priming was observed when the primed picture followed the prime sentence. Thus, repetition priming was observed even when the primes were processed while the participants prepared an unrelated spoken utterance. Priming might, therefore, support utterance planning in conversation, where speakers routinely listen while planning their utterances.

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  • Bašnákova, J., Van Berkum, J. J. A., Weber, K., & Hagoort, P. (2015). A job interview in the MRI scanner: How does indirectness affect addressees and overhearers? Neuropsychologia, 76, 79-91. doi:10.1016/j.neuropsychologia.2015.03.030.

    Abstract

    In using language, people not only exchange information, but also navigate their social world – for example, they can express themselves indirectly to avoid losing face. In this functional magnetic resonance imaging study, we investigated the neural correlates of interpreting face-saving indirect replies, in a situation where participants only overheard the replies as part of a conversation between two other people, as well as in a situation where the participants were directly addressed themselves. We created a fictional job interview context where indirect replies serve as a natural communicative strategy to attenuate one’s shortcomings, and asked fMRI participants to either pose scripted questions and receive answers from three putative job candidates (addressee condition) or to listen to someone else interview the same candidates (overhearer condition). In both cases, the need to evaluate the candidate ensured that participants had an active interest in comprehending the replies. Relative to direct replies, face-saving indirect replies increased activation in medial prefrontal cortex, bilateral temporo-parietal junction (TPJ), bilateral inferior frontal gyrus and bilateral middle temporal gyrus, in active overhearers and active addressees alike, with similar effect size, and comparable to findings obtained in an earlier passive listening study (Bašnáková et al., 2013). In contrast, indirectness effects in bilateral anterior insula and pregenual ACC, two regions implicated in emotional salience and empathy, were reliably stronger in addressees than in active overhearers. Our findings indicate that understanding face-saving indirect language requires additional cognitive perspective-taking and other discourse-relevant cognitive processing, to a comparable extent in active overhearers and addressees. Furthermore, they indicate that face-saving indirect language draws upon affective systems more in addressees than in overhearers, presumably because the addressee is the one being managed by a face-saving reply. In all, face-saving indirectness provides a window on the cognitive as well as affect-related neural systems involved in human communication.
  • Bastiaansen, M. C. M., & Hagoort, P. (2015). Frequency-based segregation of syntactic and semantic unification during online sentence level language comprehension. Journal of Cognitive Neuroscience, 27(11), 2095-2107. doi:10.1162/jocn_a_00829.

    Abstract

    During sentence level language comprehension, semantic and syntactic unification are functionally distinct operations. Nevertheless, both recruit roughly the same brain areas (spatially overlapping networks in the left frontotemporal cortex) and happen at the same time (in the first few hundred milliseconds after word onset). We tested the hypothesis that semantic and syntactic unification are segregated by means of neuronal synchronization of the functionally relevant networks in different frequency ranges: gamma (40 Hz and up) for semantic unification and lower beta (10–20 Hz) for syntactic unification. EEG power changes were quantified as participants read either correct sentences, syntactically correct though meaningless sentences (syntactic prose), or sentences that did not contain any syntactic structure (random word lists). Other sentences contained either a semantic anomaly or a syntactic violation at a critical word in the sentence. Larger EEG gamma-band power was observed for semantically coherent than for semantically anomalous sentences. Similarly, beta-band power was larger for syntactically correct sentences than for incorrect ones. These results confirm the existence of a functional dissociation in EEG oscillatory dynamics during sentence level language comprehension that is compatible with the notion of a frequency-based segregation of syntactic and semantic unification.
  • Bastos, A. M., Vezoli, J., Bosman, C. A., Schoffelen, J.-M., Oostenveld, R., Dowdall, J. R., De Weerd, P., Kennedy, H., & Fries, P. (2015). Visual areas exert feedforward and feedback influences through distinct frequency channels. Neuron, 85(2), 390-401. doi:10.1016/j.neuron.2014.12.018.

    Abstract

    Visual cortical areas subserve cognitive functions by interacting in both feedforward and feedback directions. While feedforward influences convey sensory signals, feedback influences modulate feedforward signaling according to the current behavioral context. We investigated whether these interareal influences are subserved differentially by rhythmic synchronization. We correlated frequency-specific directed influences among 28 pairs of visual areas with anatomical metrics of the feedforward or feedback character of the respective interareal projections. This revealed that in the primate visual system, feedforward influences are carried by theta-band ( approximately 4 Hz) and gamma-band ( approximately 60-80 Hz) synchronization, and feedback influences by beta-band ( approximately 14-18 Hz) synchronization. The functional directed influences constrain a functional hierarchy similar to the anatomical hierarchy, but exhibiting task-dependent dynamic changes in particular with regard to the hierarchical positions of frontal areas. Our results demonstrate that feedforward and feedback signaling use distinct frequency channels, suggesting that they subserve differential communication requirements.
  • Bauer, B. L. M. (2019). Language contact and language borrowing? Compound verb forms in the Old French translation of the Gospel of St. Mark. Belgian Journal of Linguistics, 33, 210-250. doi:10.1075/bjl.00028.bau.

    Abstract

    This study investigates the potential influence of Latin syntax on the development of analytic verb forms in a well-defined and concrete instance of language contact, the Old French translation of a Latin Gospel. The data show that the formation of verb forms in the Old French was remarkably independent from the Latin original. While the Old French text closely follows the narrative of the Latin Gospel, its usage of compound verb forms is not dictated by the source text, as reflected e.g. in the quasi-omnipresence of the relative sequence finite verb + pp, which – with a few exceptions – all trace back to a different structure in the Latin text. Engels (VerenigdeStaten) Another important innovative difference in the Old French is the widespread use of aveir ‘have’ as an auxiliary, unknown in Latin. The article examines in detail the relation between the verbal forms in the two texts, showing that the translation is in line with of grammar. The usage of compound verb forms in the Old French Gospel is therefore autonomous rather than contact stimulated, let alone contact induced. The results challenge Blatt’s (1957) assumption identifying compound verb forms as a shared feature in European languages that should be ascribed to Latin influence.

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  • Bauer, B. L. M. (2015). Origins of grammatical forms and evidence from Latin. Journal of Indo-European studies, 43, 201-235.

    Abstract

    This article submits that the instances of incipient grammaticalization that are found in the later stages of Latin and that resulted in new grammatical forms in Romance, reflect a major linguistic innovation. While the new grammatical forms are created out of lexical or mildly grammatical autonomous elements, earlier processes seem to primarily involve particles with a certain semantic value and freezing. This fundamental difference explains why the attempts of early Indo-Europeanists such as Franz Bopp at tracing the lexical origins of Indo-European inflected forms were unsuccessful and strongly criticized by the Neo-Grammarians.
  • Becker, M., Devanna, P., Fisher, S. E., & Vernes, S. C. (2015). A chromosomal rearrangement in a child with severe speech and language disorder separates FOXP2 from a functional enhancer. Molecular Cytogenetics, 8: 69. doi:10.1186/s13039-015-0173-0.

    Abstract

    Mutations of FOXP2 in 7q31 cause a rare disorder involving speech apraxia, accompanied by expressive and receptive language impairments. A recent report described a child with speech and language deficits, and a genomic rearrangement affecting chromosomes 7 and 11. One breakpoint mapped to 7q31 and, although outside its coding region, was hypothesised to disrupt FOXP2 expression. We identified an element 2 kb downstream of this breakpoint with epigenetic characteristics of an enhancer. We show that this element drives reporter gene expression in human cell-lines. Thus, displacement of this element by translocation may disturb gene expression, contributing to the observed language phenotype.
  • Bekemeier, N., Brenner, D., Klepp, A., Biermann-Ruben, K., & Indefrey, P. (2019). Electrophysiological correlates of concept type shifts. PLoS One, 14(3): e0212624. doi:10.1371/journal.pone.0212624.

    Abstract

    A recent semantic theory of nominal concepts by Löbner [1] posits that–due to their inherent uniqueness and relationality properties–noun concepts can be classified into four concept types (CTs): sortal, individual, relational, functional. For sortal nouns the default determination is indefinite (a stone), for individual nouns it is definite (the sun), for relational and functional nouns it is possessive (his ear, his father). Incongruent determination leads to a concept type shift: his father (functional concept: unique, relational)–a father (sortal concept: non-unique, non-relational). Behavioral studies on CT shifts have demonstrated a CT congruence effect, with congruent determiners triggering faster lexical decision times on the subsequent noun than incongruent ones [2, 3]. The present ERP study investigated electrophysiological correlates of congruent and incongruent determination in German noun phrases, and specifically, whether the CT congruence effect could be indexed by such classic ERP components as N400, LAN or P600. If incongruent determination affects the lexical retrieval or semantic integration of the noun, it should be reflected in the amplitude of the N400 component. If, however, CT congruence is processed by the same neuronal mechanisms that underlie morphosyntactic processing, incongruent determination should trigger LAN or/and P600. These predictions were tested in two ERP studies. In Experiment 1, participants just listened to noun phrases. In Experiment 2, they performed a wellformedness judgment task. The processing of (in)congruent CTs (his sun vs. the sun) was compared to the processing of morphosyntactic and semantic violations in control conditions. Whereas the control conditions elicited classic electrophysiological violation responses (N400, LAN, & P600), CT-incongruences did not. Instead they showed novel concept-type specific response patterns. The absence of the classic ERP components suggests that CT-incongruent determination is not perceived as a violation of the semantic or morphosyntactic structure of the noun phrase.

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  • Benetti, S., Zonca, J., Ferrari, A., Rezk, M., Rabini, G., & Collignon, O. (2021). Visual motion processing recruits regions selective for auditory motion in early deaf individuals. NeuroImage, 230: 117816. doi:10.1016/j.neuroimage.2021.117816.

    Abstract

    In early deaf individuals, the auditory deprived temporal brain regions become engaged in visual processing. In our study we tested further the hypothesis that intrinsic functional specialization guides the expression of cross-modal responses in the deprived auditory cortex. We used functional MRI to characterize the brain response to horizontal, radial and stochastic visual motion in early deaf and hearing individuals matched for the use of oral or sign language. Visual motion showed enhanced response in the ‘deaf’ mid-lateral planum temporale, a region selective to auditory motion as demonstrated by a separate auditory motion localizer in hearing people. Moreover, multivariate pattern analysis revealed that this reorganized temporal region showed enhanced decoding of motion categories in the deaf group, while visual motion-selective region hMT+/V5 showed reduced decoding when compared to hearing people. Dynamic Causal Modelling revealed that the ‘deaf’ motion-selective temporal region shows a specific increase of its functional interactions with hMT+/V5 and is now part of a large-scale visual motion selective network. In addition, we observed preferential responses to radial, compared to horizontal, visual motion in the ‘deaf’ right superior temporal cortex region that also show preferential response to approaching/receding sounds in the hearing brain. Overall, our results suggest that the early experience of auditory deprivation interacts with intrinsic constraints and triggers a large-scale reallocation of computational load between auditory and visual brain regions that typically support the multisensory processing of motion information.

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  • Bentum, M., Ten Bosch, L., Van den Bosch, A., & Ernestus, M. (2019). Do speech registers differ in the predictability of words? International Journal of Corpus Linguistics, 24(1), 98-130. doi:10.1075/ijcl.17062.ben.

    Abstract

    Previous research has demonstrated that language use can vary depending on the context of situation. The present paper extends this finding by comparing word predictability differences between 14 speech registers ranging from highly informal conversations to read-aloud books. We trained 14 statistical language models to compute register-specific word predictability and trained a register classifier on the perplexity score vector of the language models. The classifier distinguishes perfectly between samples from all speech registers and this result generalizes to unseen materials. We show that differences in vocabulary and sentence length cannot explain the speech register classifier’s performance. The combined results show that speech registers differ in word predictability.
  • Bergelson*, E., Casillas*, M., Soderstrom, M., Seidl, A., Warlaumont, A. S., & Amatuni, A. (2019). What Do North American Babies Hear? A large-scale cross-corpus analysis. Developmental Science, 22(1): e12724. doi:10.1111/desc.12724.

    Abstract

    - * indicates joint first authorship - Abstract: A range of demographic variables influence how much speech young children hear. However, because studies have used vastly different sampling methods, quantitative comparison of interlocking demographic effects has been nearly impossible, across or within studies. We harnessed a unique collection of existing naturalistic, day-long recordings from 61 homes across four North American cities to examine language input as a function of age, gender, and maternal education. We analyzed adult speech heard by 3- to 20-month-olds who wore audio recorders for an entire day. We annotated speaker gender and speech register (child-directed or adult-directed) for 10,861 utterances from female and male adults in these recordings. Examining age, gender, and maternal education collectively in this ecologically-valid dataset, we find several key results. First, the speaker gender imbalance in the input is striking: children heard 2--3x more speech from females than males. Second, children in higher-maternal-education homes heard more child-directed speech than those in lower-maternal education homes. Finally, our analyses revealed a previously unreported effect: the proportion of child-directed speech in the input increases with age, due to a decrease in adult-directed speech with age. This large-scale analysis is an important step forward in collectively examining demographic variables that influence early development, made possible by pooled, comparable, day-long recordings of children's language environments. The audio recordings, annotations, and annotation software are readily available for re-use and re-analysis by other researchers.

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  • Berghuis, B., De Kovel, C. G. F., van Iterson, L., Lamberts, R. J., Sander, J. W., Lindhout, D., & Koeleman, B. P. C. (2015). Complex SCN8A DNA-abnormalities in an individual with therapy resistant absence epilepsy. Epilepsy Research, 115, 141-144. doi:10.1016/j.eplepsyres.2015.06.007.

    Abstract

    Background De novo SCN8A missense mutations have been identified as a rare dominant cause of epileptic encephalopathy. We described a person with epileptic encephalopathy associated with a mosaic deletion of the SCN8A gene. Methods Array comparative genome hybridization was used to identify chromosomal abnormalities. Next Generation Sequencing was used to screen for variants in known and candidate epilepsy genes. A single nucleotide polymorphism array was used to test whether the SCN8A variants were in cis or in trans. Results We identified a de novo mosaic deletion of exons 2–14 of SCN8A, and a rare maternally inherited missense variant on the other allele in a woman presenting with absence seizures, challenging behavior, intellectual disability and QRS-fragmentation on the ECG. We also found a variant in SCN5A. Conclusions The combination of a rare missense variant with a de novo mosaic deletion of a large part of the SCN8A gene suggests that other possible mechanisms for SCN8A mutations may cause epilepsy; loss of function, genetic modifiers and cellular interference may play a role. This case expands the phenotype associated with SCN8A mutations, with absence epilepsy and regression in language and memory skills.
  • Bergmann, C., Bosch, L. t., Fikkert, P., & Boves, L. (2015). Modelling the Noise-Robustness of Infants’ Word Representations: The Impact of Previous Experience. PLoS One, 10(7): e0132245. doi:10.1371/journal.pone.0132245.

    Abstract

    During language acquisition, infants frequently encounter ambient noise. We present a computational model to address whether specific acoustic processing abilities are necessary to detect known words in moderate noise—an ability attested experimentally in infants. The model implements a general purpose speech encoding and word detection procedure. Importantly, the model contains no dedicated processes for removing or cancelling out ambient noise, and it can replicate the patterns of results obtained in several infant experiments. In addition to noise, we also addressed the role of previous experience with particular target words: does the frequency of a word matter, and does it play a role whether that word has been spoken by one or multiple speakers? The simulation results show that both factors affect noise robustness. We also investigated how robust word detection is to changes in speaker identity by comparing words spoken by known versus unknown speakers during the simulated test. This factor interacted with both noise level and past experience, showing that an increase in exposure is only helpful when a familiar speaker provides the test material. Added variability proved helpful only when encountering an unknown speaker. Finally, we addressed whether infants need to recognise specific words, or whether a more parsimonious explanation of infant behaviour, which we refer to as matching, is sufficient. Recognition involves a focus of attention on a specific target word, while matching only requires finding the best correspondence of acoustic input to a known pattern in the memory. Attending to a specific target word proves to be more noise robust, but a general word matching procedure can be sufficient to simulate experimental data stemming from young infants. A change from acoustic matching to targeted recognition provides an explanation of the improvements observed in infants around their first birthday. In summary, we present a computational model incorporating only the processes infants might employ when hearing words in noise. Our findings show that a parsimonious interpretation of behaviour is sufficient and we offer a formal account of emerging abilities.
  • Bertamini, M., Rampone, G., Makin, A. D. J., & Jessop, A. (2019). Symmetry preference in shapes, faces, flowers and landscapes. PeerJ, 7: e7078. doi:10.7717/peerj.7078.

    Abstract

    Most people like symmetry, and symmetry has been extensively used in visual art and architecture. In this study, we compared preference for images of abstract and familiar objects in the original format or when containing perfect bilateral symmetry. We created pairs of images for different categories: male faces, female faces, polygons, smoothed version of the polygons, flowers, and landscapes. This design allows us to compare symmetry preference in different domains. Each observer saw all categories randomly interleaved but saw only one of the two images in a pair. After recording preference, we recorded a rating of how salient the symmetry was for each image, and measured how quickly observers could decide which of the two images in a pair was symmetrical. Results reveal a general preference for symmetry in the case of shapes and faces. For landscapes, natural (no perfect symmetry) images were preferred. Correlations with judgments of saliency were present but generally low, and for landscapes the salience of symmetry was negatively related to preference. However, even within the category where symmetry was not liked (landscapes), the separate analysis of original and modified stimuli showed an interesting pattern: Salience of symmetry was correlated positively (artificial) or negatively (original) with preference, suggesting different effects of symmetry within the same class of stimuli based on context and categorization.

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  • Bidgood, A., Pine, J., Rowland, C. F., Sala, G., Freudenthal, D., & Ambridge, B. (2021). Verb argument structure overgeneralisations for the English intransitive and transitive constructions: Grammaticality judgments and production priming. Language and Cognition, 13(3), 397-437. doi:10.1017/langcog.2021.8.

    Abstract

    We used a multi-method approach to investigate how children avoid (or retreat from) argument structure overgeneralisation errors (e.g., *You giggled me). Experiment 1 investigated how semantic and statistical constraints (preemption and entrenchment) influence children’s and adults’ judgments of the grammatical acceptability of 120 verbs in transitive and intransitive sentences. Experiment 2 used syntactic priming to elicit overgeneralisation errors from children (aged 5–6) to investigate whether the same constraints operate in production. For judgments, the data showed effects of preemption, entrenchment, and semantics for all ages. For production, only an effect of preemption was observed, and only for transitivisation errors with intransitive-only verbs (e.g., *The man laughed the girl). We conclude that preemption, entrenchment, and semantic effects are real, but are obscured by particular features of the present production task.

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    supplementary material
  • Bielczyk, N. Z., Piskała, K., Płomecka, M., Radziński, P., Todorova, L., & Foryś, U. (2019). Time-delay model of perceptual decision making in cortical networks. PLoS One, 14: e0211885. doi:10.1371/journal.pone.0211885.

    Abstract

    It is known that cortical networks operate on the edge of instability, in which oscillations can appear. However, the influence of this dynamic regime on performance in decision making, is not well understood. In this work, we propose a population model of decision making based on a winner-take-all mechanism. Using this model, we demonstrate that local slow inhibition within the competing neuronal populations can lead to Hopf bifurcation. At the edge of instability, the system exhibits ambiguity in the decision making, which can account for the perceptual switches observed in human experiments. We further validate this model with fMRI datasets from an experiment on semantic priming in perception of ambivalent (male versus female) faces. We demonstrate that the model can correctly predict the drop in the variance of the BOLD within the Superior Parietal Area and Inferior Parietal Area while watching ambiguous visual stimuli.

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  • Birhane, A., & Guest, O. (2021). Towards decolonising computational sciences. Kvinder, Køn & Forskning, 29(2), 60-73. doi:10.7146/kkf.v29i2.124899.

    Abstract

    This article sets out our perspective on how to begin the journey of decolonising computational fi elds, such as data and cognitive sciences. We see this struggle as requiring two basic steps: a) realisation that the present-day system has inherited, and still enacts, hostile, conservative, and oppressive behaviours and principles towards women of colour; and b) rejection of the idea that centring individual people is a solution to system-level problems. The longer we ignore these two steps, the more “our” academic system maintains its toxic structure, excludes, and harms Black women and other minoritised groups. This also keeps the door open to discredited pseudoscience, like eugenics and physiognomy. We propose that grappling with our fi elds’ histories and heritage holds the key to avoiding mistakes of the past. In contrast to, for example, initiatives such as “diversity boards”, which can be harmful because they superfi cially appear reformatory but nonetheless center whiteness and maintain the status quo. Building on the work of many women of colour, we hope to advance the dialogue required to build both a grass-roots and a top-down re-imagining of computational sciences — including but not limited to psychology, neuroscience, cognitive science, computer science, data science, statistics, machine learning, and artifi cial intelligence. We aspire to progress away from
    these fi elds’ stagnant, sexist, and racist shared past into an ecosystem that welcomes and nurtures
    demographically diverse researchers and ideas that critically challenge the status quo.
  • Blackwell, N. L., Perlman, M., & Fox Tree, J. E. (2015). Quotation as a multimodal construction. Journal of Pragmatics, 81, 1-7. doi:10.1016/j.pragma.2015.03.004.

    Abstract

    Quotations are a means to report a broad range of events in addition to speech, and often involve both vocal and bodily demonstration. The present study examined the use of quotation to report a variety of multisensory events (i.e., containing salient visible and audible elements) as participants watched and then described a set of video clips including human speech and animal vocalizations. We examined the relationship between demonstrations conveyed through the vocal versus bodily modality, comparing them across four common quotation devices (be like, go, say, and zero quotatives), as well as across direct and non-direct quotations and retellings. We found that direct quotations involved high levels of both vocal and bodily demonstration, while non-direct quotations involved lower levels in both these channels. In addition, there was a strong positive correlation between vocal and bodily demonstration for direct quotation. This result supports a Multimodal Hypothesis where information from the two channels arises from one central concept.
  • Blair, H. J., Ho, M., Monaco, A. P., Fisher, S. E., Craig, I. W., & Boyd, Y. (1995). High-resolution comparative mapping of the proximal region of the mouse X chromosome. Genomics, 28(2), 305-310. doi:10.1006/geno.1995.1146.

    Abstract

    The murine homologues of the loci for McLeod syndrome (XK), Dent's disease (CICN5), and synaptophysin (SYP) have been mapped to the proximal region of the mouse X chromosome and positioned with respect to other conserved loci in this region using a total of 948 progeny from two separate Mus musculus x Mus spretus backcrosses. In the mouse, the order of loci and evolutionary breakpoints (EB) has been established as centromere-(DXWas70, DXHXF34h)-EB-Clcn5-(Syp, DXMit55, DXMit26)-Tfe3-Gata1-EB-Xk-Cybb-telomere. In the proximal region of the human X chromosome short arm, the position of evolutionary breakpoints with respect to key loci has been established as DMD-EB-XK-PFC-EB-GATA1-C1CN5-EB-DXS1272E-ALAS2-E B-DXF34-centromere. These data have enabled us to construct a high-resolution genetic map for the approximately 3-cM interval between DXWas70 and Cybb on the mouse X chromosome, which encompasses 10 loci. This detailed map demonstrates the power of high-resolution genetic mapping in the mouse as a means of determining locus order in a small chromosomal region and of providing an accurate framework for the construction of physical maps.
  • Blasi, D. E., Moran, S., Moisik, S. R., Widmer, P., Dediu, D., & Bickel, B. (2019). Human sound systems are shaped by post-Neolithic changes in bite configuration. Science, 363(6432): eaav3218. doi:10.1126/science.aav3218.

    Abstract

    Linguistic diversity, now and in the past, is widely regarded to be independent of biological changes that took place after the emergence of Homo sapiens. We show converging evidence from paleoanthropology, speech biomechanics, ethnography, and historical linguistics that labiodental sounds (such as “f” and “v”) were innovated after the Neolithic. Changes in diet attributable to food-processing technologies modified the human bite from an edge-to-edge configuration to one that preserves adolescent overbite and overjet into adulthood. This change favored the emergence and maintenance of labiodentals. Our findings suggest that language is shaped not only by the contingencies of its history, but also by culturally induced changes in human biology.

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  • De Bleser, R., Willmes, K., Graetz, P., & Hagoort, P. (1991). De Akense Afasie Test. Logopedie en Foniatrie, 63, 207-217.
  • Bluijs, S., Dera, J., & Peeters, D. (2021). Waarom digitale literatuur in het literatuuronderwijs thuishoort. Tijdschrift voor Nederlandse Taal- en Letterkunde, 137(2), 150-163. doi:10.5117/TNTL2021.2.003.BLUI.
  • Blythe, J. (2015). Other-initiated repair in Murrinh-Patha. Open Linguistics, 1, 283-308. doi:10.1515/opli-2015-0003.

    Abstract

    The range of linguistic structures and interactional practices associated with other-initiated repair (OIR) is surveyed for the Northern Australian language Murrinh-Patha. By drawing on a video corpus of informal Murrinh- Patha conversation, the OIR formats are compared in terms of their utility and versatility. Certain “restricted” formats have semantic properties that point to prior trouble source items. While these make the restricted repair initiators more specialised, the “open” formats are less well resourced semantically, which makes them more versatile. They tend to be used when the prior talk is potentially problematic in more ways than one. The open formats (especially thangku, “what?”) tend to solicit repair operations on each potential source of trouble, such that the resultant repair solution improves upon the troublesource turn in several ways
  • Bocanegra, B. R., Poletiek, F. H., Ftitache, B., & Clark, A. (2019). Intelligent problem-solvers externalize cognitive operations. Nature Human Behaviour, 3, 136-142. doi:10.1038/s41562-018-0509-y.

    Abstract

    Humans are nature’s most intelligent and prolific users of external props and aids (such as written texts, slide-rules and software packages). Here we introduce a method for investigating how people make active use of their task environment during problem-solving and apply this approach to the non-verbal Raven Advanced Progressive Matrices test for fluid intelligence. We designed a click-and-drag version of the Raven test in which participants could create different external spatial configurations while solving the puzzles. In our first study, we observed that the click-and-drag test was better than the conventional static test at predicting academic achievement of university students. This pattern of results was partially replicated in a novel sample. Importantly, environment-altering actions were clustered in between periods of apparent inactivity, suggesting that problem-solvers were delicately balancing the execution of internal and external cognitive operations. We observed a systematic relationship between this critical phasic temporal signature and improved test performance. Our approach is widely applicable and offers an opportunity to quantitatively assess a powerful, although understudied, feature of human intelligence: our ability to use external objects, props and aids to solve complex problems.
  • Bode, S., Feuerriegel, D., Bennett, D., & Alday, P. M. (2019). The Decision Decoding ToolBOX (DDTBOX) -- A Multivariate Pattern Analysis Toolbox for Event-Related Potentials. Neuroinformatics, 17(1), 27-42. doi:10.1007/s12021-018-9375-z.

    Abstract

    In recent years, neuroimaging research in cognitive neuroscience has increasingly used multivariate pattern analysis (MVPA) to investigate higher cognitive functions. Here we present DDTBOX, an open-source MVPA toolbox for electroencephalography (EEG) data. DDTBOX runs under MATLAB and is well integrated with the EEGLAB/ERPLAB and Fieldtrip toolboxes (Delorme and Makeig 2004; Lopez-Calderon and Luck 2014; Oostenveld et al. 2011). It trains support vector machines (SVMs) on patterns of event-related potential (ERP) amplitude data, following or preceding an event of interest, for classification or regression of experimental variables. These amplitude patterns can be extracted across space/electrodes (spatial decoding), time (temporal decoding), or both (spatiotemporal decoding). DDTBOX can also extract SVM feature weights, generate empirical chance distributions based on shuffled-labels decoding for group-level statistical testing, provide estimates of the prevalence of decodable information in the population, and perform a variety of corrections for multiple comparisons. It also includes plotting functions for single subject and group results. DDTBOX complements conventional analyses of ERP components, as subtle multivariate patterns can be detected that would be overlooked in standard analyses. It further allows for a more explorative search for information when no ERP component is known to be specifically linked to a cognitive process of interest. In summary, DDTBOX is an easy-to-use and open-source toolbox that allows for characterising the time-course of information related to various perceptual and cognitive processes. It can be applied to data from a large number of experimental paradigms and could therefore be a valuable tool for the neuroimaging community.
  • Bögels, S., & Torreira, F. (2021). Turn-end estimation in conversational turn-taking: The roles of context and prosody. Discourse Processes, 58(10), 903-924. doi:10.1080/0163853X.2021.1986664.

    Abstract

    This study investigated the role of contextual and prosodic information in turn-end estimation by means of a button-press task. We presented participants with turns extracted from a corpus of telephone calls visually (i.e., in transcribed form, word-by-word) and auditorily, and asked them to anticipate turn ends by pressing a button. The availability of the previous conversational context was generally helpful for turn-end estimation in short turns only, and more clearly so in the visual task than in the auditory task. To investigate the role of prosody, we examined whether participants in the auditory task pressed the button close to turn-medial points likely to constitute turn ends based on lexico-syntactic information alone. We observed that the vast majority of such button presses occurred in the presence of an intonational boundary rather than in its absence. These results are consistent with the view that prosodic cues in the proximity of turn ends play a relevant role in turn-end estimation.
  • Bögels, S., Barr, D., Garrod, S., & Kessler, K. (2015). Conversational interaction in the scanner: Mentalizing during language processing as revealed by MEG. Cerebral Cortex, 25(9), 3219-3234. doi:10.1093/cercor/bhu116.

    Abstract

    Humans are especially good at taking another’s perspective — representing what others might be thinking or experiencing. This “mentalizing” capacity is apparent in everyday human interactions and conversations. We investigated its neural basis using magnetoencephalography. We focused on whether mentalizing was engaged spontaneously and routinely to understand an utterance’s meaning or largely on-demand, to restore "common ground" when expectations were violated. Participants conversed with 1 of 2 confederate speakers and established tacit agreements about objects’ names. In a subsequent “test” phase, some of these agreements were violated by either the same or a different speaker. Our analysis of the neural processing of test phase utterances revealed recruitment of neural circuits associated with language (temporal cortex), episodic memory (e.g., medial temporal lobe), and mentalizing (temporo-parietal junction and ventro-medial prefrontal cortex). Theta oscillations (3 - 7 Hz) were modulated most prominently, and we observed phase coupling between functionally distinct neural circuits. The episodic memory and language circuits were recruited in anticipation of upcoming referring expressions, suggesting that context-sensitive predictions were spontaneously generated. In contrast, the mentalizing areas were recruited on-demand, as a means for detecting and resolving perceived pragmatic anomalies, with little evidence they were activated to make partner-specific predictions about upcoming linguistic utterances.
  • Bögels, S., & Torreira, F. (2015). Listeners use intonational phrase boundaries to project turn ends in spoken interaction. Journal of phonetics, 52, 46-57. doi:10.1016/j.wocn.2015.04.004.

    Abstract

    In conversation, turn transitions between speakers often occur smoothly, usually within a time window of a few hundred milliseconds. It has been argued, on the basis of a button-press experiment [De Ruiter, J. P., Mitterer, H., & Enfield, N. J. (2006). Projecting the end of a speaker's turn: A cognitive cornerstone of conversation. Language, 82(3):515–535], that participants in conversation rely mainly on lexico-syntactic information when timing and producing their turns, and that they do not need to make use of intonational cues to achieve smooth transitions and avoid overlaps. In contrast to this view, but in line with previous observational studies, our results from a dialogue task and a button-press task involving questions and answers indicate that the identification of the end of intonational phrases is necessary for smooth turn-taking. In both tasks, participants never responded to questions (i.e., gave an answer or pressed a button to indicate a turn end) at turn-internal points of syntactic completion in the absence of an intonational phrase boundary. Moreover, in the button-press task, they often pressed the button at the same point of syntactic completion when the final word of an intonational phrase was cross-spliced at that location. Furthermore, truncated stimuli ending in a syntactic completion point but lacking an intonational phrase boundary led to significantly delayed button presses. In light of these results, we argue that earlier claims that intonation is not necessary for correct turn-end projection are misguided, and that research on turn-taking should continue to consider intonation as a source of turn-end cues along with other linguistic and communicative phenomena.
  • Bögels, S., Magyari, L., & Levinson, S. C. (2015). Neural signatures of response planning occur midway through an incoming question in conversation. Scientific Reports, 5: 12881. doi:10.1038/srep12881.

    Abstract

    A striking puzzle about language use in everyday conversation is that turn-taking latencies are usually very short, whereas planning language production takes much longer. This implies overlap between language comprehension and production processes, but the nature and extent of such overlap has never been studied directly. Combining an interactive quiz paradigm with EEG measurements in an innovative way, we show that production planning processes start as soon as possible, that is, within half a second after the answer to a question can be retrieved (up to several seconds before the end of the question). Localization of ERP data shows early activation even of brain areas related to late stages of production planning (e.g., syllabification). Finally, oscillation results suggest an attention switch from comprehension to production around the same time frame. This perspective from interactive language use throws new light on the performance characteristics that language competence involves.
  • Bögels, S., Kendrick, K. H., & Levinson, S. C. (2015). Never say no… How the brain interprets the pregnant pause in conversation. PLoS One, 10(12): e0145474. doi:10.1371/journal.pone.0145474.

    Abstract

    In conversation, negative responses to invitations, requests, offers, and the like are more likely to occur with a delay – conversation analysts talk of them as dispreferred. Here we examine the contrastive cognitive load ‘yes’ and ‘no’ responses make, either when relatively fast (300 ms after question offset) or delayed (1000 ms). Participants heard short dialogues contrasting in speed and valence of response while having their EEG recorded. We found that a fast ‘no’ evokes an N400-effect relative to a fast ‘yes’; however this contrast disappeared in the delayed responses. 'No' responses however elicited a late frontal positivity both if they were fast and if they were delayed. We interpret these results as follows: a fast ‘no’ evoked an N400 because an immediate response is expected to be positive – this effect disappears as the response time lengthens because now in ordinary conversation the probability of a ‘no’ has increased. However, regardless of the latency of response, a ‘no’ response is associated with a late positivity, since a negative response is always dispreferred. Together these results show that negative responses to social actions exact a higher cognitive load, but especially when least expected, in immediate response.

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  • Boland, J. E., & Cutler, A. (1995). Interaction with autonomy: Defining multiple output models in psycholinguistic theory. Working Papers in Linguistic, 45, 1-10. Retrieved from http://hdl.handle.net/2066/15768.

    Abstract

    There are currently a number of psycholinguistic models in which processing at a particular level of representation is characterized by the generation of multiple outputs, with resolution involving the use of information from higher levels of processing. Surprisingly, models with this architecture have been characterized as autonomous within the domain of word recognition and as interactive within the domain of sentence processing. We suggest that the apparent internal confusion is not, as might be assumed, due to fundamental differences between lexical and syntactic processing. Rather, we believe that the labels in each domain were chosen in order to obtain maximal contrast between a new model and the model or models that were currently dominating the field.
  • Boland, J. E., & Cutler, A. (1995). Interaction with autonomy: Multiple Output models and the inadequacy of the Great Divide. Cognition, 58, 309-320. doi:10.1016/0010-0277(95)00684-2.

    Abstract

    There are currently a number of psycholinguistic models in which processing at a particular level of representation is characterized by the generation of multiple outputs, with resolution - but not generation - involving the use of information from higher levels of processing. Surprisingly, models with this architecture have been characterized as autonomous within the domain of word recognition but as interactive within the domain of sentence processing. We suggest that the apparent confusion is not, as might be assumed, due to fundamental differences between lexical and syntactic processing. Rather, we believe that the labels in each domain were chosen in order to obtain maximal contrast between a new model and the model or models that were currently dominating the field. The contradiction serves to highlight the inadequacy of a simple autonomy/interaction dichotomy for characterizing the architectures of current processing models.
  • Bornkessel-Schlesewsky, I., Alday, P. M., Kretzschmar, F., Grewe, T., Gumpert, M., Schumacher, P. B., & Schlesewsky, M. (2015). Age-related changes in predictive capacity versus internal model adaptability: Electrophysiological evidence that individual differences outweigh effects of age. Frontiers in Aging Neuroscience, 7: 217. doi:10.3389/fnagi.2015.00217.

    Abstract

    Hierarchical predictive coding has been identified as a possible unifying principle of brain function, and recent work in cognitive neuroscience has examined how it may be affected by age–related changes. Using language comprehension as a test case, the present study aimed to dissociate age-related changes in prediction generation versus internal model adaptation following a prediction error. Event-related brain potentials (ERPs) were measured in a group of older adults (60–81 years; n = 40) as they read sentences of the form “The opposite of black is white/yellow/nice.” Replicating previous work in young adults, results showed a target-related P300 for the expected antonym (“white”; an effect assumed to reflect a prediction match), and a graded N400 effect for the two incongruous conditions (i.e. a larger N400 amplitude for the incongruous continuation not related to the expected antonym, “nice,” versus the incongruous associated condition, “yellow”). These effects were followed by a late positivity, again with a larger amplitude in the incongruous non-associated versus incongruous associated condition. Analyses using linear mixed-effects models showed that the target-related P300 effect and the N400 effect for the incongruous non-associated condition were both modulated by age, thus suggesting that age-related changes affect both prediction generation and model adaptation. However, effects of age were outweighed by the interindividual variability of ERP responses, as reflected in the high proportion of variance captured by the inclusion of by-condition random slopes for participants and items. We thus argue that – at both a neurophysiological and a functional level – the notion of general differences between language processing in young and older adults may only be of limited use, and that future research should seek to better understand the causes of interindividual variability in the ERP responses of older adults and its relation to cognitive performance.
  • Bosker, H. R. (2021). Using fuzzy string matching for automated assessment of listener transcripts in speech intelligibility studies. Behavior Research Methods, 53(5), 1945-1953. doi:10.3758/s13428-021-01542-4.

    Abstract

    Many studies of speech perception assess the intelligibility of spoken sentence stimuli by means
    of transcription tasks (‘type out what you hear’). The intelligibility of a given stimulus is then often
    expressed in terms of percentage of words correctly reported from the target sentence. Yet scoring
    the participants’ raw responses for words correctly identified from the target sentence is a time-
    consuming task, and hence resource-intensive. Moreover, there is no consensus among speech
    scientists about what specific protocol to use for the human scoring, limiting the reliability of
    human scores. The present paper evaluates various forms of fuzzy string matching between
    participants’ responses and target sentences, as automated metrics of listener transcript accuracy.
    We demonstrate that one particular metric, the Token Sort Ratio, is a consistent, highly efficient,
    and accurate metric for automated assessment of listener transcripts, as evidenced by high
    correlations with human-generated scores (best correlation: r = 0.940) and a strong relationship to
    acoustic markers of speech intelligibility. Thus, fuzzy string matching provides a practical tool for
    assessment of listener transcript accuracy in large-scale speech intelligibility studies. See
    https://tokensortratio.netlify.app for an online implementation.
  • Bosker, H. R., Badaya, E., & Corley, M. (2021). Discourse markers activate their, like, cohort competitors. Discourse Processes, 58(9), 837-851. doi:10.1080/0163853X.2021.1924000.

    Abstract

    Speech in everyday conversations is riddled with discourse markers (DMs), such as well, you know, and like. However, in many lab-based studies of speech comprehension, such DMs are typically absent from the carefully articulated and highly controlled speech stimuli. As such, little is known about how these DMs influence online word recognition. The present study specifically investigated the online processing of DM like and how it influences the activation of words in the mental lexicon. We specifically targeted the cohort competitor (CC) effect in the Visual World Paradigm: Upon hearing spoken instructions to “pick up the beaker,” human listeners also typically fixate—next to the target object—referents that overlap phonologically with the target word (cohort competitors such as beetle; CCs). However, several studies have argued that CC effects are constrained by syntactic, semantic, pragmatic, and discourse constraints. Therefore, the present study investigated whether DM like influences online word recognition by activating its cohort competitors (e.g., lightbulb). In an eye-tracking experiment using the Visual World Paradigm, we demonstrate that when participants heard spoken instructions such as “Now press the button for the, like … unicycle,” they showed anticipatory looks to the CC referent (lightbulb)well before hearing the target. This CC effect was sustained for a relatively long period of time, even despite hearing disambiguating information (i.e., the /k/ in like). Analysis of the reaction times also showed that participants were significantly faster to select CC targets (lightbulb) when preceded by DM like. These findings suggest that seemingly trivial DMs, such as like, activate their CCs, impacting online word recognition. Thus, we advocate a more holistic perspective on spoken language comprehension in naturalistic communication, including the processing of DMs.
  • Bosker, H. R., & Peeters, D. (2021). Beat gestures influence which speech sounds you hear. Proceedings of the Royal Society B: Biological Sciences, 288: 20202419. doi:10.1098/rspb.2020.2419.

    Abstract

    Beat gestures—spontaneously produced biphasic movements of the hand—
    are among the most frequently encountered co-speech gestures in human
    communication. They are closely temporally aligned to the prosodic charac-
    teristics of the speech signal, typically occurring on lexically stressed
    syllables. Despite their prevalence across speakers of the world’s languages,
    how beat gestures impact spoken word recognition is unclear. Can these
    simple ‘flicks of the hand’ influence speech perception? Across a range
    of experiments, we demonstrate that beat gestures influence the explicit
    and implicit perception of lexical stress (e.g. distinguishing OBject from
    obJECT), and in turn can influence what vowels listeners hear. Thus, we pro-
    vide converging evidence for a manual McGurk effect: relatively simple and
    widely occurring hand movements influence which speech sounds we hear

    Additional information

    example stimuli and experimental data
  • Bosker, H. R., Van Os, M., Does, R., & Van Bergen, G. (2019). Counting 'uhm's: how tracking the distribution of native and non-native disfluencies influences online language comprehension. Journal of Memory and Language, 106, 189-202. doi:10.1016/j.jml.2019.02.006.

    Abstract

    Disfluencies, like 'uh', have been shown to help listeners anticipate reference to low-frequency words. The associative account of this 'disfluency bias' proposes that listeners learn to associate disfluency with low-frequency referents based on prior exposure to non-arbitrary disfluency distributions (i.e., greater probability of low-frequency words after disfluencies). However, there is limited evidence for listeners actually tracking disfluency distributions online. The present experiments are the first to show that adult listeners, exposed to a typical or more atypical disfluency distribution (i.e., hearing a talker unexpectedly say uh before high-frequency words), flexibly adjust their predictive strategies to the disfluency distribution at hand (e.g., learn to predict high-frequency referents after disfluency). However, when listeners were presented with the same atypical disfluency distribution but produced by a non-native speaker, no adjustment was observed. This suggests pragmatic inferences can modulate distributional learning, revealing the flexibility of, and constraints on, distributional learning in incremental language comprehension.
  • Braden, R. O., Amor, D. J., Fisher, S. E., Mei, C., Myers, C. T., Mefford, H., Gill, D., Srivastava, S., Swanson, L. C., Goel, H., Scheffer, I. E., & Morgan, A. T. (2021). Severe speech impairment is a distinguishing feature of FOXP1-related disorder. Developmental Medicine & Child Neurology, 63(12), 1417-1426. doi:10.1111/dmcn.14955.

    Abstract

    Aim
    To delineate the speech and language phenotype of a cohort of individuals with FOXP1-related disorder.

    Method
    We administered a standardized test battery to examine speech and oral motor function, receptive and expressive language, non-verbal cognition, and adaptive behaviour. Clinical history and cognitive assessments were analysed together with speech and language findings.

    Results
    Twenty-nine patients (17 females, 12 males; mean age 9y 6mo; median age 8y [range 2y 7mo–33y]; SD 6y 5mo) with pathogenic FOXP1 variants (14 truncating, three missense, three splice site, one in-frame deletion, eight cytogenic deletions; 28 out of 29 were de novo variants) were studied. All had atypical speech, with 21 being verbal and eight minimally verbal. All verbal patients had dysarthric and apraxic features, with phonological deficits in most (14 out of 16). Language scores were low overall. In the 21 individuals who carried truncating or splice site variants and small deletions, expressive abilities were relatively preserved compared with comprehension.

    Interpretation
    FOXP1-related disorder is characterized by a complex speech and language phenotype with prominent dysarthria, broader motor planning and programming deficits, and linguistic-based phonological errors. Diagnosis of the speech phenotype associated with FOXP1-related dysfunction will inform early targeted therapy.

    Additional information

    figure S1 table S1
  • Brand, S., & Ernestus, M. (2021). Reduction of word-final obstruent-liquid-schwa clusters in Parisian French. Corpus Linguistics and Linguistic Theory, 17(1), 249-285. doi:10.1515/cllt-2017-0067.

    Abstract

    This corpus study investigated pronunciation variants of word-final obstruent-liquid-schwa (OLS) clusters in nouns in casual Parisian French. Results showed that at least one phoneme was absent in 80.7% of the 291 noun tokens in the dataset, and that the whole cluster was absent (e.g., [mis] for ministre) in no less than 15.5% of the tokens. We demonstrate that phonemes are not always completely absent, but that they may leave traces on neighbouring phonemes. Further, the clusters display undocumented voice assimilation patterns. Statistical modelling showed that a phoneme is most likely to be absent if the following phoneme is also absent. The durations of the phonemes are conditioned particularly by the position of the word in the prosodic phrase. We argue, on the basis of three different types of evidence, that in French word-final OLS clusters, the absence of obstruents is mainly due to gradient reduction processes, whereas the absence of schwa and liquids may also be due to categorical deletion processes.
  • Brascamp, J., Klink, P., & Levelt, W. J. M. (2015). The ‘laws’ of binocular rivalry: 50 years of Levelt’s propositions. Vision Research, 109, 20-37. doi:10.1016/j.visres.2015.02.019.

    Abstract

    It has been fifty years since Levelt’s monograph On Binocular Rivalry (1965) was published, but its four propositions that describe the relation between stimulus strength and the phenomenology of binocular rivalry remain a benchmark for theorists and experimentalists even today. In this review, we will revisit the original conception of the four propositions and the scientific landscape in which this happened. We will also provide a brief update concerning distributions of dominance durations, another aspect of Levelt’s monograph that has maintained a prominent presence in the field. In a critical evaluation of Levelt’s propositions against current knowledge of binocular rivalry we will then demonstrate that the original propositions are not completely compatible with what is known today, but that they can, in a straightforward way, be modified to encapsulate the progress that has been made over the past fifty years. The resulting modified, propositions are shown to apply to a broad range of bistable perceptual phenomena, not just binocular rivalry, and they allow important inferences about the underlying neural systems. We argue that these inferences reflect canonical neural properties that play a role in visual perception in general, and we discuss ways in which future research can build on the work reviewed here to attain a better understanding of these properties
  • Brehm, L., & Meyer, A. S. (2021). Planning when to say: Dissociating cue use in utterance initiation using cross-validation. Journal of Experimental Psychology: General, 150(9), 1772-1799. doi:10.1037/xge0001012.

    Abstract

    In conversation, turns follow each other with minimal gaps. To achieve this, speakers must launch their utterances shortly before the predicted end of the partner’s turn. We examined the relative importance of cues to partner utterance content and partner utterance length for launching coordinated speech. In three experiments, Dutch adult participants had to produce prepared utterances (e.g., vier, “four”) immediately after a recording of a confederate’s utterance (zeven, “seven”). To assess the role of corepresenting content versus attending to speech cues in launching coordinated utterances, we varied whether the participant could see the stimulus being named by the confederate, the confederate prompt’s length, and whether within a block of trials, the confederate prompt’s length was predictable. We measured how these factors affected the gap between turns and the participants’ allocation of visual attention while preparing to speak. Using a machine-learning technique, model selection by k-fold cross-validation, we found that gaps were most strongly predicted by cues from the confederate speech signal, though some benefit was also conferred by seeing the confederate’s stimulus. This shows that, at least in a simple laboratory task, speakers rely more on cues in the partner’s speech than corepresentation of their utterance content.
  • Brehm, L., Jackson, C. N., & Miller, K. L. (2021). Probabilistic online processing of sentence anomalies. Language, Cognition and Neuroscience, 36(8), 959-983. doi:10.1080/23273798.2021.1900579.

    Abstract

    Listeners can successfully interpret the intended meaning of an utterance even when it contains errors or other unexpected anomalies. The present work combines an online measure of attention to sentence referents (visual world eye-tracking) with offline judgments of sentence meaning to disclose how the interpretation of anomalous sentences unfolds over time in order to explore mechanisms of non-literal processing. We use a metalinguistic judgment in Experiment 1 and an elicited imitation task in Experiment 2. In both experiments, we focus on one morphosyntactic anomaly (Subject-verb agreement; The key to the cabinets literally *were … ) and one semantic anomaly (Without; Lulu went to the gym without her hat ?off) and show that non-literal referents to each are considered upon hearing the anomalous region of the sentence. This shows that listeners understand anomalies by overwriting or adding to an initial interpretation and that this occurs incrementally and adaptively as the sentence unfolds.
  • Brehm, L., Taschenberger, L., & Meyer, A. S. (2019). Mental representations of partner task cause interference in picture naming. Acta Psychologica, 199: 102888. doi:10.1016/j.actpsy.2019.102888.

    Abstract

    Interference in picture naming occurs from representing a partner's preparations to speak (Gambi, van de Cavey, & Pickering, 2015). We tested the origins of this interference using a simple non-communicative joint naming task based on Gambi et al. (2015), where response latencies indexed interference from partner task and partner speech content, and eye fixations to partner objects indexed overt attention. Experiment 1 contrasted a partner-present condition with a control partner-absent condition to establish the role of the partner in eliciting interference. For latencies, we observed interference from the partner's task and speech content, with interference increasing due to partner task in the partner-present condition. Eye-tracking measures showed that interference in naming was not due to overt attention to partner stimuli but to broad expectations about likely utterances. Experiment 2 examined whether an equivalent non-verbal task also elicited interference, as predicted from a language as joint action framework. We replicated the finding of interference due to partner task and again found no relationship between overt attention and interference. These results support Gambi et al. (2015). Individuals co-represent a partner's task while speaking, and doing so does not require overt attention to partner stimuli.
  • Brehm, L., Jackson, C. N., & Miller, K. L. (2019). Speaker-specific processing of anomalous utterances. Quarterly Journal of Experimental Psychology, 72(4), 764-778. doi:10.1177/1747021818765547.

    Abstract

    Existing work shows that readers often interpret grammatical errors (e.g., The key to the cabinets *were shiny) and sentence-level blends (“without-blend”: Claudia left without her headphones *off) in a non-literal fashion, inferring that a more frequent or more canonical utterance was intended instead. This work examines how interlocutor identity affects the processing and interpretation of anomalous sentences. We presented anomalies in the context of “emails” attributed to various writers in a self-paced reading paradigm and used comprehension questions to probe how sentence interpretation changed based upon properties of the item and properties of the “speaker.” Experiment 1 compared standardised American English speakers to L2 English speakers; Experiment 2 compared the same standardised English speakers to speakers of a non-Standardised American English dialect. Agreement errors and without-blends both led to more non-literal responses than comparable canonical items. For agreement errors, more non-literal interpretations also occurred when sentences were attributed to speakers of Standardised American English than either non-Standardised group. These data suggest that understanding sentences relies on expectations and heuristics about which utterances are likely. These are based upon experience with language, with speaker-specific differences, and upon more general cognitive biases.

    Additional information

    Supplementary material
  • Brennan, J. R., & Martin, A. E. (2019). Phase synchronization varies systematically with linguistic structure composition. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences, 375(1791): 20190305. doi:10.1098/rstb.2019.0305.

    Abstract

    Computation in neuronal assemblies is putatively reflected in the excitatory and inhibitory cycles of activation distributed throughout the brain. In speech and language processing, coordination of these cycles resulting in phase synchronization has been argued to reflect the integration of information on different timescales (e.g. segmenting acoustics signals to phonemic and syllabic representations; (Giraud and Poeppel 2012 Nat. Neurosci.15, 511 (doi:10.1038/nn.3063)). A natural extension of this claim is that phase synchronization functions similarly to support the inference of more abstract higher-level linguistic structures (Martin 2016 Front. Psychol.7, 120; Martin and Doumas 2017 PLoS Biol. 15, e2000663 (doi:10.1371/journal.pbio.2000663); Martin and Doumas. 2019 Curr. Opin. Behav. Sci.29, 77–83 (doi:10.1016/j.cobeha.2019.04.008)). Hale et al. (Hale et al. 2018 Finding syntax in human encephalography with beam search. arXiv 1806.04127 (http://arxiv.org/abs/1806.04127)) showed that syntactically driven parsing decisions predict electroencephalography (EEG) responses in the time domain; here we ask whether phase synchronization in the form of either inter-trial phrase coherence or cross-frequency coupling (CFC) between high-frequency (i.e. gamma) bursts and lower-frequency carrier signals (i.e. delta, theta), changes as the linguistic structures of compositional meaning (viz., bracket completions, as denoted by the onset of words that complete phrases) accrue. We use a naturalistic story-listening EEG dataset from Hale et al. to assess the relationship between linguistic structure and phase alignment. We observe increased phase synchronization as a function of phrase counts in the delta, theta, and gamma bands, especially for function words. A more complex pattern emerged for CFC as phrase count changed, possibly related to the lack of a one-to-one mapping between ‘size’ of linguistic structure and frequency band—an assumption that is tacit in recent frameworks. These results emphasize the important role that phase synchronization, desynchronization, and thus, inhibition, play in the construction of compositional meaning by distributed neural networks in the brain.
  • Brouwer, S., & Bradlow, A. R. (2015). The temporal dynamics of spoken word recognition in adverse listening conditions. Journal of Psycholinguistic Research. Advanced online publication. doi:10.1007/s10936-015-9396-9.

    Abstract

    This study examined the temporal dynamics of spoken word recognition in noise and background speech. In two visual-world experiments, English participants listened to target words while looking at four pictures on the screen: a target (e.g. candle), an onset competitor (e.g. candy), a rhyme competitor (e.g. sandal), and an unrelated distractor (e.g. lemon). Target words were presented in quiet, mixed with broadband noise, or mixed with background speech. Results showed that lexical competition changes throughout the observation window as a function of what is presented in the background. These findings suggest that, rather than being strictly sequential, stream segregation and lexical competition interact during spoken word recognition
  • Brown, P., Sicoli, M. A., & Le Guen, O. (2021). Cross-speaker repetition and epistemic stance in Tzeltal, Yucatec, and Zapotec conversations. Journal of Pragmatics, 183, 256-272. doi:10.1016/j.pragma.2021.07.005.

    Abstract

    As a turn-design strategy, repeating another has been described for English as a fairly restricted way of constructing a response, which, through re-saying what another speaker just said, is exploitable for claiming epistemic primacy, and thus avoided when a second speaker has no direct experience. Conversations in Mesoamerican languages present a challenge to the generality of this claim. This paper examines the epistemics of dialogic repetition in video-recordings of conversations in three Indigenous languages of Mexico: Tzeltal and Yucatec Maya, both spoken in southeastern Mexico, and Lachixío Zapotec, spoken in Oaxaca. We develop a typology of repetition in different sequential environments. We show that while the functions of repeats in Mesoamerica overlap with the range of repeat functions described for English, there is an additional epistemic environment in the Mesoamerican routine of repeating for affirmation: a responding speaker can repeat to affirm something introduced by another speaker of which s/he has no prior knowledge. We argue that, while dialogic repetition is a universally available turn-design strategy that makes epistemics potentially relevant, cross-cultural comparison reveals that cultural preferences intervene such that, in Mesoamerican conversations, repetition co-constructs knowledge as collective process over which no individual participant has final authority or ownership.

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  • Brown, A. R., Pouw, W., Brentari, D., & Goldin-Meadow, S. (2021). People are less susceptible to illusion when they use their hands to communicate rather than estimate. Psychological Science, 32, 1227-1237. doi:10.1177/0956797621991552.

    Abstract

    When we use our hands to estimate the length of a stick in the Müller-Lyer illusion, we are highly susceptible to the illusion. But when we prepare to act on sticks under the same conditions, we are significantly less susceptible. Here, we asked whether people are susceptible to illusion when they use their hands not to act on objects but to describe them in spontaneous co-speech gestures or conventional sign languages of the deaf. Thirty-two English speakers and 13 American Sign Language signers used their hands to act on, estimate the length of, and describe sticks eliciting the Müller-Lyer illusion. For both gesture and sign, the magnitude of illusion in the description task was smaller than the magnitude of illusion in the estimation task and not different from the magnitude of illusion in the action task. The mechanisms responsible for producing gesture in speech and sign thus appear to operate not on percepts involved in estimation but on percepts derived from the way we act on objects.

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    supplementary material data via OSF
  • Brown-Schmidt, S., & Konopka, A. E. (2015). Processes of incremental message planning during conversation. Psychonomic Bulletin & Review, 22, 833-843. doi:10.3758/s13423-014-0714-2.

    Abstract

    Speaking begins with the formulation of an intended preverbal message and linguistic encoding of this information. The transition from thought to speech occurs incrementally, with cascading planning at subsequent levels of production. In this article, we aim to specify the mechanisms that support incremental message preparation. We contrast two hypotheses about the mechanisms responsible for incorporating message-level information into a linguistic plan. According to the Initial Preparation view, messages can be encoded as fluent utterances if all information is ready before speaking begins. By contrast, on the Continuous Incrementality view, messages can be continually prepared and updated throughout the production process, allowing for fluent production even if new information is added to the message while speaking is underway. Testing these hypotheses, eye-tracked speakers in two experiments produced unscripted, conjoined noun phrases with modifiers. Both experiments showed that new message elements can be incrementally incorporated into the utterance even after articulation begins, consistent with a Continuous Incrementality view of message planning, in which messages percolate to linguistic encoding immediately as that information becomes available in the mind of the speaker. We conclude by discussing the functional role of incremental message planning in conversational speech and the situations in which this continuous incremental planning would be most likely to be observed
  • Brucato, N., Guadalupe, T., Franke, B., Fisher, S. E., & Francks, C. (2015). A schizophrenia-associated HLA locus affects thalamus volume and asymmetry. Brain, Behavior, and Immunity, 46, 311-318. doi:10.1016/j.bbi.2015.02.021.

    Abstract

    Genes of the Major Histocompatibility Complex (MHC) have recently been shown to have neuronal functions in the thalamus and hippocampus. Common genetic variants in the Human Leukocyte Antigens (HLA) region, human homologue of the MHC locus, are associated with small effects on susceptibility to schizophrenia, while volumetric changes of the thalamus and hippocampus have also been linked to schizophrenia. We therefore investigated whether common variants of the HLA would affect volumetric variation of the thalamus and hippocampus. We analyzed thalamus and hippocampus volumes, as measured using structural magnetic resonance imaging, in 1.265 healthy participants. These participants had also been genotyped using genome-wide single nucleotide polymorphism (SNP) arrays. We imputed genotypes for single nucleotide polymorphisms at high density across the HLA locus, as well as HLA allotypes and HLA amino acids, by use of a reference population dataset that was specifically targeted to the HLA region. We detected a significant association of the SNP rs17194174 with thalamus volume (nominal P=0.0000017, corrected P=0.0039), as well as additional SNPs within the same region of linkage disequilibrium. This effect was largely lateralized to the left thalamus and is localized within a genomic region previously associated with schizophrenia. The associated SNPs are also clustered within a potential regulatory element, and a region of linkage disequilibrium that spans genes expressed in the thalamus, including HLA-A. Our data indicate that genetic variation within the HLA region influences the volume and asymmetry of the human thalamus. The molecular mechanisms underlying this association may relate to HLA influences on susceptibility to schizophrenia
  • Bull, L. E., Oliver, C., Callaghan, E., & Woodcock, K. A. (2015). Increased Exposure to Rigid Routines can Lead to Increased Challenging Behavior Following Changes to Those Routines. Journal of Autism and Developmental Disorders, 45(6), 1569-1578. doi:10.1007/s10803-014-2308-2.

    Abstract

    Several neurodevelopmental disorders are associated with preference for routine and challenging behavior following changes to routines. We examine individuals with Prader–Willi syndrome, who show elevated levels of this behavior, to better understand how previous experience of a routine can affect challenging behavior elicited by disruption to that routine. Play based challenges exposed 16 participants to routines, which were either adhered to or changed. Temper outburst behaviors, heart rate and movement were measured. As participants were exposed to routines for longer before a change (between 10 and 80 min; within participants), more temper outburst behaviors were elicited by changes. Increased emotional arousal was also elicited, which was indexed by heart rate increases not driven by movement. Further study will be important to understand whether current intervention approaches that limit exposure to changes, may benefit from the structured integration of flexibility to ensure that the opportunity for routine establishment is also limited.

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    10803_2014_2308_MOESM1_ESM.docx
  • Burgers, N., Ettema, D. F., Hooimeijer, P., & Barendse, M. T. (2021). The effects of neighbours on sport club membership. European Journal for Sport and Society, 18(4), 310-325. doi:10.1080/16138171.2020.1840710.

    Abstract

    Neighbours have been found to influence each other’s behaviour (contagion effect). However, little is known about the influence on sport club membership. This while increasing interest has risen for the social role of sport clubs. Sport clubs could bring people from different backgrounds together. A mixed composition is a key element in this social role. Individual characteristics are strong predictors of sport club membership. Western high educated men are more likely to be members. In contrast to people with a non-Western migration background. The neighbourhood is a more fixed meeting place, which provides unique opportunities for people from different backgrounds to interact. This study aims to gain more insight into the influence of neighbours on sport club membership. This research looks especially at the composition of neighbour’s migration background, since they tend to be more or less likely to be members and therefore could encourage of inhibit each other. A population database including the only registry data of all Dutch inhabitants was merged with data of 11 sport unions. The results show a cross-level effect of neighbours on sport club membership. We find a contagion effect of neighbours’ migration background; having a larger proportion of neighbours with a migration background from a non-Western country reduces the odds, as expected. However, this contagion effect was not found for people with a Moroccan or Turkish background.
  • Burra, N., Hervais-Adelman, A., Celeghin, A., de Gelder, B., & Pegna, A. J. (2019). Affective blindsight relies on low spatial frequencies. Neuropsychologia, 128, 44-49. doi:10.1016/j.neuropsychologia.2017.10.009.

    Abstract

    The human brain can process facial expressions of emotions rapidly and without awareness. Several studies in patients with damage to their primary visual cortices have shown that they may be able to guess the emotional expression on a face despite their cortical blindness. This non-conscious processing, called affective blindsight, may arise through an intact subcortical visual route that leads from the superior colliculus to the pulvinar, and thence to the amygdala. This pathway is thought to process the crude visual information conveyed by the low spatial frequencies of the stimuli.

    In order to investigate whether this is the case, we studied a patient (TN) with bilateral cortical blindness and affective blindsight. An fMRI paradigm was performed in which fearful and neutral expressions were presented using faces that were either unfiltered, or filtered to remove high or low spatial frequencies. Unfiltered fearful faces produced right amygdala activation although the patient was unaware of the presence of the stimuli. More importantly, the low spatial frequency components of fearful faces continued to produce right amygdala activity while the high spatial frequency components did not. Our findings thus confirm that the visual information present in the low spatial frequencies is sufficient to produce affective blindsight, further suggesting that its existence could rely on the subcortical colliculo-pulvino-amygdalar pathway.
  • Byers-Heinlein, K., Tsui, A. S. M., Bergmann, C., Black, A. K., Brown, A., Carbajal, M. J., Durrant, S., Fennell, C. T., Fiévet, A.-C., Frank, M. C., Gampe, A., Gervain, J., Gonzalez-Gomez, N., Hamlin, J. K., Havron, N., Hernik, M., Kerr, S., Killam, H., Klassen, K., Kosie, J. and 18 moreByers-Heinlein, K., Tsui, A. S. M., Bergmann, C., Black, A. K., Brown, A., Carbajal, M. J., Durrant, S., Fennell, C. T., Fiévet, A.-C., Frank, M. C., Gampe, A., Gervain, J., Gonzalez-Gomez, N., Hamlin, J. K., Havron, N., Hernik, M., Kerr, S., Killam, H., Klassen, K., Kosie, J., Kovács, Á. M., Lew-Williams, C., Liu, L., Mani, N., Marino, C., Mastroberardino, M., Mateu, V., Noble, C., Orena, A. J., Polka, L., Potter, C. E., Schreiner, M., Singh, L., Soderstrom, M., Sundara, M., Waddell, C., Werker, J. F., & Wermelinger, S. (2021). A multilab study of bilingual infants: Exploring the preference for infant-directed speech. Advances in Methods and Practices in Psychological Science, 4(1), 1-30. doi:10.1177/2515245920974622.

    Abstract

    From the earliest months of life, infants prefer listening to and learn better from infant-directed speech (IDS) than adult-directed speech (ADS). Yet, IDS differs within communities, across languages, and across cultures, both in form and in prevalence. This large-scale, multi-site study used the diversity of bilingual infant experiences to explore the impact of different types of linguistic experience on infants’ IDS preference. As part of the multi-lab ManyBabies project, we compared lab-matched samples of 333 bilingual and 385 monolingual infants’ preference for North-American English IDS (cf. ManyBabies Consortium, in press (MB1)), tested in 17 labs in 7 countries. Those infants were tested in two age groups: 6–9 months (the younger sample) and 12–15 months (the older sample). We found that bilingual and monolingual infants both preferred IDS to ADS, and did not differ in terms of the overall magnitude of this preference. However, amongst bilingual infants who were acquiring North-American English (NAE) as a native language, greater exposure to NAE was associated with a stronger IDS preference, extending the previous finding from MB1 that monolinguals learning NAE as a native language showed a stronger preference than infants unexposed to NAE. Together, our findings indicate that IDS preference likely makes a similar contribution to monolingual and bilingual development, and that infants are exquisitely sensitive to the nature and frequency of different types of language input in their early environments.
  • Caldwell-Harris, C. L., Lancaster, A., Ladd, D. R., Dediu, D., & Christiansen, M. H. (2015). Factors influencing sensitivity to lexical tone in an artificial language: Implications for second language learning. Studies in Second Language Acquisition, 37(2), 335-357. doi:10.1017/S0272263114000849.

    Abstract

    This study examined whether musical training, ethnicity, and experience with a natural tone language influenced sensitivity to tone while listening to an artificial tone language. The language was designed with three tones, modeled after level-tone African languages. Participants listened to a 15-min random concatenation of six 3-syllable words. Sensitivity to tone was assessed using minimal pairs differing only in one syllable (nonword task: e.g., to-kà-su compared to ca-fí-to) or only in tone (tone task: e.g., to-kà-su compared to to-ká-su). Proficiency in an East Asian heritage language was the strongest predictor of success on the tone task. Asians without tone language experience were no better than other ethnic groups. We conclude by considering implications for research on second language learning, especially as approached through artificial language learning.
  • Calkoen, F., Vervat, C., van Pel, M., de Haas, V., Vijfhuizen, L., Eising, E., Kroes, W., Hoen, P., van den Heuvel-Eibrink, M., Egeler, R., Van Tol, M., & Ball, L. (2015). Despite differential gene expression profiles pediatric MDS derived mesenchymal stromal cells display functionality in vitro. Stem Cell Research, 14(2), 198-210. doi:10.1016/j.scr.2015.01.006.

    Abstract

    Pediatric myelodysplastic syndrome (MDS) is a heterogeneous disease covering a spectrum ranging from aplasia (RCC) to myeloproliferation (RAEB(t)). In adult-type MDS there is increasing evidence for abnormal function of the bone-marrow microenvironment. Here, we extensively studied the mesenchymal stromal cells (MSCs) derived from children with MDS. MSCs were expanded from the bone-marrow of 17 MDS patients (RCC: n = 10 and advanced MDS: n = 7) and pediatric controls (n = 10). No differences were observed with respect to phenotype, differentiation capacity, immunomodulatory capacity or hematopoietic support. mRNA expression analysis by Deep-SAGE revealed increased IL-6 expression in RCC- and RAEB(t)-MDS. RCC-MDS MSC expressed increased levels of DKK3, a protein associated with decreased apoptosis. RAEB(t)-MDS revealed increased CRLF1 and decreased DAPK1 expressions. This pattern has been associated with transformation in hematopoietic malignancies. Genes reported to be differentially expressed in adult MDS-MSC did not differ between MSC of pediatric MDS and controls. An altered mRNA expression profile, associated with cell survival and malignant transformation, of MSC derived from children with MDS strengthens the hypothesis that the micro-environment is of importance in this disease. Our data support the understanding that pediatric and adult MDS are two different diseases. Further evaluation of the pathways involved might reveal additional therapy targets.
  • Calkoen, F. G., Vervat, C., Eising, E., Vijfhuizen, L. S., 't Hoen, P.-B.-A., van den Heuvel-Eibrink, M. M., & Egeler, R. M. (2015). Gene-expression and in vitro function of mesenchymal stromal cells are affected in juvenile myelomonocytic leukemia. Haematologica, 100(11), 1434-1441. doi:10.3324/haematol.2015.126938.

    Abstract

    An aberrant interaction between hematopoietic stem cells and mesenchymal stromal cells has been linked to disease and shown to contribute to the pathophysiology of hematologic malignancies in murine models. Juvenile myelomonocytic leukemia is an aggressive malignant disease affecting young infants. Here we investigated the impact of juvenile myelomonocytic leukemia on mesenchymal stromal cells. Mesenchymal stromal cells were expanded from bone marrow samples of patients at diagnosis (n=9) and after hematopoietic stem cell transplantation (n=7; from 5 patients) and from healthy children (n=10). Cells were characterized by phenotyping, differentiation, gene expression analysis (of controls and samples obtained at diagnosis) and in vitro functional studies assessing immunomodulation and hematopoietic support. Mesenchymal stromal cells from patients did not differ from controls in differentiation capacity nor did they differ in their capacity to support in vitro hematopoiesis. Deep-SAGE sequencing revealed differential mRNA expression in patient-derived samples, including genes encoding proteins involved in immunomodulation and cell-cell interaction. Selected gene expression normalized during remission after successful hematopoietic stem cell transplantation. Whereas natural killer cell activation and peripheral blood mononuclear cell proliferation were not differentially affected, the suppressive effect on monocyte to dendritic cell differentiation was increased by mesenchymal stromal cells obtained at diagnosis, but not at time of remission. This study shows that active juvenile myelomonocytic leukemia affects the immune response-related gene expression and function of mesenchymal stromal cells. In contrast, the differential gene expression of hematopoiesis-related genes could not be supported by functional data. Decreased immune surveillance might contribute to the therapy resistance and progression in juvenile myelomonocytic leukemia.
  • Carota, F., Nili, H., Pulvermüller, F., & Kriegeskorte, N. (2021). Distinct fronto-temporal substrates of distributional and taxonomic similarity among words: Evidence from RSA of BOLD signals. NeuroImage, 224: 117408. doi:10.1016/j.neuroimage.2020.117408.

    Abstract

    A class of semantic theories defines concepts in terms of statistical distributions of lexical items, basing meaning on vectors of word co-occurrence frequencies. A different approach emphasizes abstract hierarchical taxonomic relationships among concepts. However, the functional relevance of these different accounts and how they capture information-encoding of meaning in the brain still remains elusive.

    We investigated to what extent distributional and taxonomic models explained word-elicited neural responses using cross-validated representational similarity analysis (RSA) of functional magnetic resonance imaging (fMRI) and novel model comparisons.

    Our findings show that the brain encodes both types of semantic similarities, but in distinct cortical regions. Posterior middle temporal regions reflected word links based on hierarchical taxonomies, along with the action-relatedness of the semantic word categories. In contrast, distributional semantics best predicted the representational patterns in left inferior frontal gyrus (LIFG, BA 47). Both representations coexisted in angular gyrus supporting semantic binding and integration. These results reveal that neuronal networks with distinct cortical distributions across higher-order association cortex encode different representational properties of word meanings. Taxonomy may shape long-term lexical-semantic representations in memory consistently with sensorimotor details of semantic categories, whilst distributional knowledge in the LIFG (BA 47) enable semantic combinatorics in the context of language use.

    Our approach helps to elucidate the nature of semantic representations essential for understanding human language.
  • Carrion Castillo, A., Estruch, S. B., Maassen, B., Franke, B., Francks, C., & Fisher, S. E. (2021). Whole-genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family. Human Genetics, 140, 1183-1200. doi:10.1007/s00439-021-02289-w.

    Abstract

    Dyslexia is a common heritable developmental disorder involving impaired reading abilities. Its genetic underpinnings are thought to be complex and heterogeneous, involving common and rare genetic variation. Multigenerational families segregating apparent monogenic forms of language-related disorders can provide useful entrypoints into biological pathways. In the present study, we performed a genome-wide linkage scan in a three-generational family in which dyslexia affects 14 of its 30 members and seems to be transmitted with an autosomal dominant pattern of inheritance. We identified a locus on chromosome 7q21.11 which cosegregated with dyslexia status, with the exception of two cases of phenocopy (LOD = 2.83). Whole-genome sequencing of key individuals enabled the assessment of coding and noncoding variation in the family. Two rare single-nucleotide variants (rs144517871 and rs143835534) within the first intron of the SEMA3C gene cosegregated with the 7q21.11 risk haplotype. In silico characterization of these two variants predicted effects on gene regulation, which we functionally validated for rs144517871 in human cell lines using luciferase reporter assays. SEMA3C encodes a secreted protein that acts as a guidance cue in several processes, including cortical neuronal migration and cellular polarization. We hypothesize that these intronic variants could have a cis-regulatory effect on SEMA3C expression, making a contribution to dyslexia susceptibility in this family.
  • Carrion Castillo, A., Van der Haegen, L., Tzourio-Mazoyer, N., Kavaklioglu, T., Badillo, S., Chavent, M., Saracco, J., Brysbaert, M., Fisher, S. E., Mazoyer, B., & Francks, C. (2019). Genome sequencing for rightward hemispheric language dominance. Genes, Brain and Behavior, 18(5): e12572. doi:10.1111/gbb.12572.

    Abstract

    Most people have left‐hemisphere dominance for various aspects of language processing, but only roughly 1% of the adult population has atypically reversed, rightward hemispheric language dominance (RHLD). The genetic‐developmental program that underlies leftward language laterality is unknown, as are the causes of atypical variation. We performed an exploratory whole‐genome‐sequencing study, with the hypothesis that strongly penetrant, rare genetic mutations might sometimes be involved in RHLD. This was by analogy with situs inversus of the visceral organs (left‐right mirror reversal of the heart, lungs and so on), which is sometimes due to monogenic mutations. The genomes of 33 subjects with RHLD were sequenced and analyzed with reference to large population‐genetic data sets, as well as 34 subjects (14 left‐handed) with typical language laterality. The sample was powered to detect rare, highly penetrant, monogenic effects if they would be present in at least 10 of the 33 RHLD cases and no controls, but no individual genes had mutations in more than five RHLD cases while being un‐mutated in controls. A hypothesis derived from invertebrate mechanisms of left‐right axis formation led to the detection of an increased mutation load, in RHLD subjects, within genes involved with the actin cytoskeleton. The latter finding offers a first, tentative insight into molecular genetic influences on hemispheric language dominance.

    Additional information

    gbb12572-sup-0001-AppendixS1.docx
  • Casillas, M., Brown, P., & Levinson, S. C. (2021). Early language experience in a Papuan community. Journal of Child Language, 48(4), 792-814. doi:10.1017/S0305000920000549.

    Abstract

    The rate at which young children are directly spoken to varies due to many factors, including (a) caregiver ideas about children as conversational partners and (b) the organization of everyday life. Prior work suggests cross-cultural variation in rates of child-directed speech is due to the former factor, but has been fraught with confounds in comparing postindustrial and subsistence farming communities. We investigate the daylong language environments of children (0;0–3;0) on Rossel Island, Papua New Guinea, a small-scale traditional community where prior ethnographic study demonstrated contingency-seeking child interaction styles. In fact, children were infrequently directly addressed and linguistic input rate was primarily affected by situational factors, though children’s vocalization maturity showed no developmental delay. We compare the input characteristics between this community and a Tseltal Mayan one in which near-parallel methods produced comparable results, then briefly discuss the models and mechanisms for learning best supported by our findings.
  • Casillas, M., & Cristia, A. (2019). A step-by-step guide to collecting and analyzing long-format speech environment (LFSE) recordings. Collabra, 5(1): 24. doi:10.1525/collabra.209.

    Abstract

    Recent years have seen rapid technological development of devices that can record communicative behavior as participants go about daily life. This paper is intended as an end-to-end methodological guidebook for potential users of these technologies, including researchers who want to study children’s or adults’ communicative behavior in everyday contexts. We explain how long-format speech environment (LFSE) recordings provide a unique view on language use and how they can be used to complement other measures at the individual and group level. We aim to help potential users of these technologies make informed decisions regarding research design, hardware, software, and archiving. We also provide information regarding ethics and implementation, issues that are difficult to navigate for those new to this technology, and on which little or no resources are available. This guidebook offers a concise summary of information for new users and points to sources of more detailed information for more advanced users. Links to discussion groups and community-augmented databases are also provided to help readers stay up-to-date on the latest developments.
  • Casillas, M., Rafiee, A., & Majid, A. (2019). Iranian herbalists, but not cooks, are better at naming odors than laypeople. Cognitive Science, 43(6): e12763. doi:10.1111/cogs.12763.

    Abstract

    Odor naming is enhanced in communities where communication about odors is a central part of daily life (e.g., wine experts, flavorists, and some hunter‐gatherer groups). In this study, we investigated how expert knowledge and daily experience affect the ability to name odors in a group of experts that has not previously been investigated in this context—Iranian herbalists; also called attars—as well as cooks and laypeople. We assessed naming accuracy and consistency for 16 herb and spice odors, collected judgments of odor perception, and evaluated participants' odor meta‐awareness. Participants' responses were overall more consistent and accurate for more frequent and familiar odors. Moreover, attars were more accurate than both cooks and laypeople at naming odors, although cooks did not perform significantly better than laypeople. Attars' perceptual ratings of odors and their overall odor meta‐awareness suggest they are also more attuned to odors than the other two groups. To conclude, Iranian attars—but not cooks—are better odor namers than laypeople. They also have greater meta‐awareness and differential perceptual responses to odors. These findings further highlight the critical role that expertise and type of experience have on olfactory functions.

    Additional information

    Supplementary Materials
  • Castells-Nobau, A., Eidhof, I., Fenckova, M., Brenman-Suttner, D. B., Scheffer-de Gooyert, J. M., Christine, S., Schellevis, R. L., Van der Laan, K., Quentin, C., Van Ninhuijs, L., Hofmann, F., Ejsmont, R., Fisher, S. E., Kramer, J. M., Sigrist, S. J., Simon, A. F., & Schenck, A. (2019). Conserved regulation of neurodevelopmental processes and behavior by FoxP in Drosophila. PLoS One, 14(2): e211652. doi:10.1371/journal.pone.0211652.

    Abstract

    FOXP proteins form a subfamily of evolutionarily conserved transcription factors involved in the development and functioning of several tissues, including the central nervous system. In humans, mutations in FOXP1 and FOXP2 have been implicated in cognitive deficits including intellectual disability and speech disorders. Drosophila exhibits a single ortholog, called FoxP, but due to a lack of characterized mutants, our understanding of the gene remains poor. Here we show that the dimerization property required for mammalian FOXP function is conserved in Drosophila. In flies, FoxP is enriched in the adult brain, showing strong expression in ~1000 neurons of cholinergic, glutamatergic and GABAergic nature. We generate Drosophila loss-of-function mutants and UAS-FoxP transgenic lines for ectopic expression, and use them to characterize FoxP function in the nervous system. At the cellular level, we demonstrate that Drosophila FoxP is required in larvae for synaptic morphogenesis at axonal terminals of the neuromuscular junction and for dendrite development of dorsal multidendritic sensory neurons. In the developing brain, we find that FoxP plays important roles in α-lobe mushroom body formation. Finally, at a behavioral level, we show that Drosophila FoxP is important for locomotion, habituation learning and social space behavior of adult flies. Our work shows that Drosophila FoxP is important for regulating several neurodevelopmental processes and behaviors that are related to human disease or vertebrate disease model phenotypes. This suggests a high degree of functional conservation with vertebrate FOXP orthologues and established flies as a model system for understanding FOXP related pathologies.
  • Cathomas, F., Azzinnari, D., Bergamini, G., Sigrist, H., Buerge, M., Hoop, V., Wicki, B., Goetze, L., Soares, S. M. P., Kukelova, D., Seifritz, E., Goebbels, S., Nave, K.-A., Ghandour, M. S., Seoighe, C., Hildebrandt, T., Leparc, G., Klein, H., Stupka, E., Hengerer, B. and 1 moreCathomas, F., Azzinnari, D., Bergamini, G., Sigrist, H., Buerge, M., Hoop, V., Wicki, B., Goetze, L., Soares, S. M. P., Kukelova, D., Seifritz, E., Goebbels, S., Nave, K.-A., Ghandour, M. S., Seoighe, C., Hildebrandt, T., Leparc, G., Klein, H., Stupka, E., Hengerer, B., & Pryce, C. R. (2019). Oligodendrocyte gene expression is reduced by and influences effects of chronic social stress in mice. Genes, Brain and Behavior, 18(1): e12475. doi:10.1111/gbb.12475.

    Abstract

    Oligodendrocyte gene expression is downregulated in stress-related neuropsychiatric disorders,
    including depression. In mice, chronic social stress (CSS) leads to depression-relevant changes
    in brain and emotional behavior, and the present study shows the involvement of oligodendrocytes in this model. In C57BL/6 (BL/6) mice, RNA-sequencing (RNA-Seq) was conducted with
    prefrontal cortex, amygdala and hippocampus from CSS and controls; a gene enrichment database for neurons, astrocytes and oligodendrocytes was used to identify cell origin of deregulated genes, and cell deconvolution was applied. To assess the potential causal contribution of
    reduced oligodendrocyte gene expression to CSS effects, mice heterozygous for the oligodendrocyte gene cyclic nucleotide phosphodiesterase (Cnp1) on a BL/6 background were studied;
    a 2 genotype (wildtype, Cnp1+/−
    ) × 2 environment (control, CSS) design was used to investigate
    effects on emotional behavior and amygdala microglia. In BL/6 mice, in prefrontal cortex and
    amygdala tissue comprising gray and white matter, CSS downregulated expression of multiple
    oligodendroycte genes encoding myelin and myelin-axon-integrity proteins, and cell deconvolution identified a lower proportion of oligodendrocytes in amygdala. Quantification of oligodendrocyte proteins in amygdala gray matter did not yield evidence for reduced translation,
    suggesting that CSS impacts primarily on white matter oligodendrocytes or the myelin transcriptome. In Cnp1 mice, social interaction was reduced by CSS in Cnp1+/− mice specifically;
    using ionized calcium-binding adaptor molecule 1 (IBA1) expression, microglia activity was
    increased additively by Cnp1+/− and CSS in amygdala gray and white matter. This study provides back-translational evidence that oligodendrocyte changes are relevant to the pathophysiology and potentially the treatment of stress-related neuropsychiatric disorders.

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