Publications

Abstract

This paper examines the verbs and other spatial vocabulary used for describing events of ‘putting’ and ‘taking’ in Tzeltal (Mayan). I discuss the semantics of different ‘put’ and ‘take’ verbs, the constructions they occur in, and the extensional patterns of verbs used in ‘put’ (Goal-oriented) vs. ‘take’ (Source-oriented) descriptions. A relatively limited role for semantically general verbs was found. Instead, Tzeltal is a ‘multiverb language’ with many different verbs usable to predicate ‘put’ and ‘take’ events, with verb choice largely determined by the shape, orientation, and resulting disposition of the Figure and Ground objects. The asymmetry that has been observed in other languages, with Goal-oriented ‘put’ verbs more finely distinguished lexically than Source-oriented ‘take’ verbs, is also apparent in Tzeltal.

Abstract

The Hmong Diaspora is one of the widest modern human migrations. Mainly localised in South-East Asia, the United States of America, and metropolitan France, a small community has also settled the Amazonian forest of French Guiana. We have biologically analysed 62 individuals of this unique Guianese population through three complementary genetic markers: mitochondrial DNA (HVS-I/II and coding region SNPs), Y-chromosome (SNPs and STRs), and the Gm allotypic system. All genetic systems showed a high conservation of the Asian gene pool (Asian ancestry: mtDNA = 100.0%; NRY = 99.1%; Gm = 96.6%), without a trace of founder effect. When compared across various Asian populations, the highest correlations were observed with Hmong-Mien groups still living in South-East Asia (Fst < 0.05; P-value < 0.05). Despite a long history punctuated by exodus, the French Guianese Hmong have maintained their original genetic diversity.

Abstract

Lexically guided perceptual learni ng refers to the use of lexical knowledge to retune sp eech categories and thereby adapt to a novel talker’s pronunciation. This adaptation has been extensively documented, but primarily for segmental-based learning in English and Dutch. In languages with lexical tone, such as Mandarin Chinese, tonal categories can also be retuned in this way, but segmental category retuning had not been studied. We report two experiment s in which Mandarin Chinese listeners were exposed to an ambiguous mixture of [f] and [s] in lexical contexts favoring an interpretation as either [f] or [s]. Listeners were subsequently more likely to identify sounds along a continuum between [f] and [s], and to interpret minimal word pairs, in a manner consistent with this exposure. Thus lexically guided perceptual learning of segmental categories had indeed taken place, consistent with suggestions that such learning may be a universally available adaptation process

Abstract

Do all humans perceive, think, and talk about tree cover ("forests") in more or less the same way? International forestry programs frequently seem to operate on the assumption that they do. However, recent advances in the language sciences show that languages vary greatly as to how the landscape domain is lexicalized and grammaticalized. Different languages segment and label the large-scale environment and its features according to astonishingly different semantic principles, often in tandem with highly culture-specific practices and ideologies. Presumed basic concepts like mountain, valley, and river cannot in fact be straightforwardly translated across languages. In this paper we describe, compare, and evaluate some of the semantic diversity observed in relation to forests. We do so on the basis of first-hand linguistic field data from a global sample of indigenous categorization systems as they are manifested in the following languages: Avatime (Ghana), Duna (Papua New Guinea), Jahai (Malay Peninsula), Lokono (the Guianas), Makalero (East Timor), and Umpila/Kuuku Ya'u (Cape York Peninsula). We show that basic linguistic categories relating to tree cover vary considerably in their principles of semantic encoding across languages, and that forest is a challenging category from the point of view of intercultural translatability. This has consequences for current global policies and programs aimed at standardizing forest definitions and measurements. It calls for greater attention to categorial diversity in designing and implementing such agendas, and for receptiveness to and understanding of local indigenous classification systems in communicating those agendas on the ground.

Abstract

This paper explores the linguistic encoding of placement and removal events in Jahai (Austroasiatic, Malay Peninsula) on the basis of descriptions from a video elicitation task. It outlines the structural characteristics of the descriptions and isolates semantically a set of situation types that find expression in lexical opposites: (1) putting/taking, (2) inserting/extracting, (3) dressing/undressing, and (4) placing/removing one’s body parts. All involve deliberate and controlled placing/removing of a solid Figure object in relation to a Ground which is not a human recipient. However, they differ as to the identity of and physical relationship between Figure and Ground. The data also provide evidence of variation in how semantic roles are mapped onto syntactic constituents: in most situation types, Agent, Figure and Ground associate with particular constituent NPs, but some placement events are described with semantically specialised verbs encoding the Figure and even the Ground.

Abstract

Nuclear receptors (NRs) form a large superfamily of transcription factors that participate in virtually every key biological process. They control development, fertility, gametogenesis and are misregulated in many cancers. Their enormous functional plasticity as transcription factors relates in part to NR-mediated interactions with hundreds of coregulatory proteins upon ligand (e.g., hormone) binding to their ligand binding domains (LBD), or following covalent modification. Some coregulator association relates to the distinct residues that shape a coactivator binding pocket termed AF-2, a surface groove that primarily determines the preference and specificity of protein–protein interactions. However, the highly conserved AF-2 pocket in the NR superfamily appears to be insufficient to account for NR subtype specificity leading to fine transcriptional modulation in certain settings. Additional protein–protein interaction surfaces, most notably on their LBD, may contribute to modulating NR function. NR coregulators and chaperones, normally much larger than the NR itself, may also bind to such interfaces. In the case of the androgen receptor (AR) LBD surface, structural and functional data highlighted the presence of another site named BF-3, which lies at a distinct but topographically adjacent surface to AF-2. AR BF-3 is a hot spot for mutations involved in prostate cancer and androgen insensitivity syndromes, and some FDA-approved drugs bind at this site. Structural studies suggested an allosteric relationship between AF-2 and BF-3, as occupancy of the latter affected coactivator recruitment to AF-2. Physiological relevant partners of AR BF-3 have not been described as yet. The newly discovered site is highly conserved among the steroid receptors subclass, but is also present in other NRs. Several missense mutations in the BF-3 regions of these human NRs are implicated in pathology and affect their function in vitro. The fact that AR BF-3 pocket is a druggable site evidences its pharmacological potential. Compounds that may affect allosterically NR function by binding to BF-3 open promising avenues to develop type-specific NR modulators.

Abstract

Background: Identifying age-related changes in cognition that contribute towards reduced driving performance is important for the development of interventions to improve older adults' driving and prolong the time that they can continue to drive. While driving, one is often required to switch from attending to events changing in time, to distribute attention spatially. Although there is extensive research into both spatial attention and temporal attention and how these change with age, the literature on switching between these modalities of attention is limited within any age group. Methods: Age groups (21-30, 40-49, 50-59, 60-69 and 70+ years) were compared on their ability to switch between detecting a target in a rapid serial visual presentation (RSVP) stream and detecting a target in a visual search display. To manipulate the cost of switching, the target in the RSVP stream was either the first item in the stream (Target 1st), towards the end of the stream (Target Mid), or absent from the stream (Distractor Only). Visual search response times and accuracy were recorded. Target 1st trials behaved as no-switch trials, as attending to the remaining stream was not necessary. Target Mid and Distractor Only trials behaved as switch trials, as attending to the stream to the end was required. Results: Visual search response times (RTs) were longer on "Target Mid" and "Distractor Only" trials in comparison to "Target 1st" trials, reflecting switch-costs. Larger switch-costs were found in both the 40-49 and 60-69 years group in comparison to the 21-30 years group when switching from the Target Mid condition. Discussion: Findings warrant further exploration as to whether there are age-related changes in the ability to switch between these modalities of attention while driving. If older adults display poor performance when switching between temporal and spatial attention while driving, then the development of an intervention to preserve and improve this ability would be beneficial. © 2017 Callaghan, Holland and Kessler.

Abstract

Word meaning processing in the brain involves ventrolateral temporal cortex, but a semantic contribution of the dorsal stream, especially frontocentral sensorimotor areas, has been controversial. We here examine brain activation during passive reading of object-related nouns from different semantic categories, notably animal, food, and tool words, matched for a range of psycholinguistic features. Results show ventral stream activation in temporal cortex along with category-specific activation patterns in both ventral and dorsal streams, including sensorimotor systems and adjacent pFC. Precentral activation reflected action-related semantic features of the word categories. Cortical regions implicated in mouth and face movements were sparked by food words, and hand area activation was seen for tool words, consistent with the actions implicated by the objects the words are used to speak about. Furthermore, tool words specifically activated the right cerebellum, and food words activated the left orbito-frontal and fusiform areas. We discuss our results in the context of category-specific semantic deficits in the processing of words and concepts, along with previous neuroimaging research, and conclude that specific dorsal and ventral areas in frontocentral and temporal cortex index visual and affective–emotional semantic attributes of object-related nouns and action-related affordances of their referent objects.

Abstract

Language comprehension engages a distributed network of frontotemporal, parietal, and sensorimotor regions, but it is still unclear how meaning of words and their semantic relationships are represented and processed within these regions and to which degrees lexico-semantic representations differ between regions and semantic types. We used fMRI and representational similarity analysis to relate word-elicited multivoxel patterns to semantic similarity between action and object words. In left inferior frontal (BA 44-45-47), left posterior middle temporal and left precentral cortex, the similarity of brain response patterns reflected semantic similarity among action-related verbs, as well as across lexical classes-between action verbs and tool-related nouns and, to a degree, between action verbs and food nouns, but not between action verbs and animal nouns. Instead, posterior inferior temporal cortex exhibited a reverse response pattern, which reflected the semantic similarity among object-related nouns, but not action-related words. These results show that semantic similarity is encoded by a range of cortical areas, including multimodal association (e.g., anterior inferior frontal, posterior middle temporal) and modality-preferential (premotor) cortex and that the representational geometries in these regions are partly dependent on semantic type, with semantic similarity among action-related words crossing lexical-semantic category boundaries.

Abstract

Dyslexia is a common specific learning disability with a substantive genetic component. Several candidate genes have been proposed to be implicated in dyslexia susceptibility, such as DYX1C1, ROBO1, KIAA0319, and DCDC2. Associations with variants in these genes have also been reported with a variety of psychometric measures tapping into the underlying processes that might be impaired in dyslexic people. In this study, we first conducted a literature review to select single nucleotide polymorphisms (SNPs) in dyslexia candidate genes that had been repeatedly implicated across studies. We then assessed the SNPs for association in the richly phenotyped longitudinal data set from the Dutch Dyslexia Program. We tested for association with several quantitative traits, including word and nonword reading fluency, rapid naming, phoneme deletion, and nonword repetition. In this, we took advantage of the longitudinal nature of the sample to examine if associations were stable across four educational time-points (from 7 to 12 years). Two SNPs in the KIAA0319 gene were nominally associated with rapid naming, and these associations were stable across different ages. Genetic association analysis with complex cognitive traits can be enriched through the use of longitudinal information on trait development.

Abstract

Although the typological contrast between Romance and Germanic languages as verb-framed versus satellite-framed (Talmy 1985) forms the background for many empirical studies on L2 acquisition, the inconclusive picture to date calls for more differentiated, fine-grained analyses. The present study goes beyond explanations based on this typological contrast and takes into account the sources from which spatial concepts are mainly derived in order to shape the trajectory traced by the entity in motion when moving through space: the entity in V-languages versus features of the ground in S-languages. It investigates why advanced French learners of English and German have difficulty acquiring the use of spatial concepts typical of the L2s to shape the trajectory, although relevant concepts can be expressed in their L1. The analysis compares motion event descriptions, based on the same sets of video clips, of L1 speakers of the three languages to L1 French-L2 English and L1 French-L2 German speakers, showing that the learners do not fully acquire the use of L2-specific spatial concepts. We argue that encoded concepts derived from the entity in motion vs. the ground lead to a focus on different aspects of motion events, in accordance with their compatibility with these sources, and are difficult to restructure in L2 acquisition.

Abstract

Can children’s handedness influence how they represent abstract concepts like kindness and intelligence? Here we show that from an early age, right-handers associate rightward space more strongly with positive ideas and leftward space with negative ideas, but the opposite is true for left-handers. In one experiment, children indicated where on a diagram a preferred toy and a dispreferred toy should go. Right-handers tended to assign the preferred toy to a box on the right and the dispreferred toy to a box on the left. Left-handers showed the opposite pattern. In a second experiment, children judged which of two cartoon animals looked smarter (or dumber) or nicer (or meaner). Right-handers attributed more positive qualities to animals on the right, but left-handers to animals on the left. These contrasting associations between space and valence cannot be explained by exposure to language or cultural conventions, which consistently link right with good. Rather, right- and left-handers implicitly associated positive valence more strongly with the side of space on which they can act more fluently with their dominant hands. Results support the body-specificity hypothesis (Casasanto, 2009), showing that children with different kinds of bodies think differently in corresponding ways.

Abstract

Introduction
The Sapir-Whorf hypothesis (a.k.a. the Whorfian hypothesis) concerns the relationship between language and thought. Neither the anthropological linguist Edward Sapir (b. 1884–d. 1939) nor his student Benjamin Whorf (b. 1897–d. 1941) ever formally stated any single hypothesis about the influence of language on nonlinguistic cognition and perception. On the basis of their writings, however, two proposals emerged, generating decades of controversy among anthropologists, linguists, philosophers, and psychologists. According to the more radical proposal, linguistic determinism, the languages that people speak rigidly determine the way they perceive and understand the world. On the more moderate proposal, linguistic relativity, habits of using language influence habits of thinking. As a result, people who speak different languages think differently in predictable ways. During the latter half of the 20th century, the Sapir-Whorf hypothesis was widely regarded as false. Around the turn of the 21st century, however, experimental evidence reopened debate about the extent to which language shapes nonlinguistic cognition and perception. Scientific tests of linguistic determinism and linguistic relativity help to clarify what is universal in the human mind and what depends on the particulars of people’s physical and social experience.
General Overviews and Foundational Texts

Writing on the relationship between language and thought predates Sapir and Whorf, and extends beyond the academy. The 19th-century German philosopher Wilhelm von Humboldt argued that language constrains people’s worldview, foreshadowing the idea of linguistic determinism later articulated in Sapir 1929 and Whorf 1956 (Humboldt 1988). The intuition that language radically determines thought has been explored in works of fiction such as Orwell’s dystopian fantasy 1984 (Orwell 1949). Although there is little empirical support for radical linguistic determinism, more moderate forms of linguistic relativity continue to generate influential research, reviewed from an anthropologist’s perspective in Lucy 1997, from a psychologist’s perspective in Hunt and Agnoli 1991, and discussed from multidisciplinary perspectives in Gumperz and Levinson 1996 and Gentner and Goldin-Meadow 2003.

Abstract

Interoperable annotation formats are fundamental to the utility, expansion, and sustainability of collective data repositories.In language development research, shared annotation schemes have been critical to facilitating the transition from raw acoustic data to searchable, structured corpora. Current schemes typically require comprehensive and manual annotation of utterance boundaries and orthographic speech content, with an additional, optional range of tags of interest. These schemes have been enormously successful for datasets on the scale of dozens of recording hours but are untenable for long-format recording corpora, which routinely contain hundreds to thousands of audio hours. Long-format corpora would benefit greatly from (semi-)automated analyses, both on the earliest steps of annotation—voice activity detection, utterance segmentation, and speaker diarization—as well as later steps—e.g., classification-based codes such as child-vs-adult-directed speech, and speech recognition to produce phonetic/orthographic representations. We present an annotation workflow specifically designed for long-format corpora which can be tailored by individual researchers and which interfaces with the current dominant scheme for short-format recordings. The workflow allows semi-automated annotation and analyses at higher linguistic levels. We give one example of how the workflow has been successfully implemented in a large cross-database project.

Abstract

Conversational turns often proceed with very brief pauses between speakers. In order to maintain “no gap, no overlap” turntaking, we must be able to anticipate when an ongoing utterance will end, tracking the current speaker for upcoming points of potential floor exchange. The precise set of cues that listeners use for turn-end boundary anticipation is not yet established. We used an eyetracking paradigm to measure adults’ and children’s online turn processing as they watched videos of conversations in their native language (English) and a range of other languages they did not speak. Both adults and children anticipated speaker transitions effectively. In addition, we observed evidence of turn-boundary anticipation for questions even in languages that were unknown to participants, suggesting that listeners’ success in turn-end anticipation does not rely solely on lexical information.

Abstract

Children begin developing turn-taking skills in infancy but take several years to fluidly integrate their growing knowledge of language into their turn-taking behavior. In two eye-tracking experiments, we measured children’s anticipatory gaze to upcoming responders while controlling linguistic cues to turn structure. In Experiment 1, we showed English and non-English conversations to English-speaking adults and children. In Experiment 2, we phonetically controlled lexicosyntactic and prosodic cues in English-only speech. Children spontaneously made anticipatory gaze switches by age two and continued improving through age six. In both experiments, children and adults made more anticipatory switches after hearing questions. Consistent with prior findings on adult turn prediction, prosodic information alone did not increase children’s anticipatory gaze shifts. But, unlike prior work with adults, lexical information alone was not sucient either—children’s performance was best overall with lexicosyntax and prosody together. Our findings support an account in which turn tracking and turn prediction emerge in infancy and then gradually become integrated with children’s online linguistic processing.

Abstract

Child-directed speech is argued to facilitate language development, and is found cross-linguistically and cross-culturally to varying degrees. However, previous research has generally focused on short samples of child-caregiver interaction, often in the lab or with experimenters present. We test the generalizability of this phenomenon with an initial descriptive analysis of the speech heard by young children in a large, unique collection of naturalistic, daylong home recordings. Trained annotators coded automatically-detected adult speech 'utterances' from 61 homes across 4 North American cities, gathered from children (age 2-24 months) wearing audio recorders during a typical day. Coders marked the speaker gender (male/female) and intended addressee (child/adult), yielding 10,886 addressee and gender tags from 2,523 minutes of audio (cf. HB-CHAAC Interspeech ComParE challenge; Schuller et al., in press). Automated speaker-diarization (LENA) incorrectly gender-tagged 30% of male adult utterances, compared to manually-coded consensus. Furthermore, we find effects of SES and gender on child-directed and overall speech, increasing child-directed speech with child age, and interactions of speaker gender, child gender, and child age: female caretakers increased their child-directed speech more with age than male caretakers did, but only for male infants. Implications for language acquisition and existing classification algorithms are discussed.

Abstract

Learning a specific skill during childhood may partly determine the functional organization of the adult brain. This hypothesis led us to study oral language processing in illiterate subjects who, for social reasons, had never entered school and had no knowledge of reading or writing. In a brain activation study using PET and statistical parametric mapping, we compared word and pseudoword repetition in literate and illiterate subjects. Our study confirms behavioural evidence of different phonological processing in illiterate subjects. During repetition of real words, the two groups performed similarly and activated similar areas of the brain. In contrast, illiterate subjects had more difficulty repeating pseudowords correctly and did not activate the same neural structures as literates. These results are consistent with the hypothesis that learning the written form of language (orthography) interacts with the function of oral language. Our results indicate that learning to read and write during childhood influences the functional organization of the adult human brain.

Abstract

Last year was the 150th anniversary of Paul Broca's landmark case report on speech disorder that paved the way for subsequent studies of cortical localization of higher cognitive functions. However, many complex functions rely on the activity of distributed networks rather than single cortical areas. Hence, it is important to understand how brain regions are linked within large-scale networks and to map lesions onto connecting white matter tracts. To facilitate this network approach we provide a synopsis of classical neurological syndromes associated with frontal, parietal, occipital, temporal and limbic lesions. A review of tractography studies in a variety of neuropsychiatric disorders is also included. The synopsis is accompanied by a new atlas of the human white matter connections based on diffusion tensor tractography freely downloadable on http://www.natbrainlab.com. Clinicians can use the maps to accurately identify the tract affected by lesions visible on conventional CT or MRI. The atlas will also assist researchers to interpret their group analysis results. We hope that the synopsis and the atlas by allowing a precise localization of white matter lesions and associated symptoms will facilitate future work on the functional correlates of human neural networks as derived from the study of clinical populations. Our goal is to stimulate clinicians to develop a critical approach to clinico-anatomical correlative studies and broaden their view of clinical anatomy beyond the cortical surface in order to encompass the dysfunction related to connecting pathways.

Abstract

The parietal lobe has a unique place in the human brain. Anatomically, it is at the crossroad between the frontal, occipital, and temporal lobes, thus providing a middle ground for multimodal sensory integration. Functionally, it supports higher cognitive functions that are characteristic of the human species, such as mathematical cognition, semantic and pragmatic aspects of language, and abstract thinking. Despite its importance, a comprehensive comparison of human and simian intraparietal networks is missing.

In this study, we used diffusion imaging tractography to reconstruct the major intralobar parietal tracts in twenty-one datasets acquired in vivo from healthy human subjects and eleven ex vivo datasets from five vervet and six macaque monkeys. Three regions of interest (postcentral gyrus, superior parietal lobule and inferior parietal lobule) were used to identify the tracts. Surface projections were reconstructed for both species and results compared to identify similarities or differences in tract anatomy (i.e., trajectories and cortical projections). In addition, post-mortem dissections were performed in a human brain.

The largest tract identified in both human and monkey brains is a vertical pathway between the superior and inferior parietal lobules. This tract can be divided into an anterior (supramarginal gyrus) and a posterior (angular gyrus) component in both humans and monkey brains. The second prominent intraparietal tract connects the postcentral gyrus to both supramarginal and angular gyri of the inferior parietal lobule in humans but only to the supramarginal gyrus in the monkey brain. The third tract connects the postcentral gyrus to the anterior region of the superior parietal lobule and is more prominent in monkeys compared to humans. Finally, short U-shaped fibres in the medial and lateral aspects of the parietal lobe were identified in both species. A tract connecting the medial parietal cortex to the lateral inferior parietal cortex was observed in the monkey brain only.

Our findings suggest a consistent pattern of intralobar parietal connections between humans and monkeys with some differences for those areas that have cytoarchitectonically distinct features in humans. The overall pattern of intraparietal connectivity supports the special role of the inferior parietal lobule in cognitive functions characteristic of humans.

Abstract

Linguistic adaptation is a phenomenon where language representations change in response to linguistic input. Adaptation can occur on multiple linguistic levels such as phonology (tuning of phonotactic constraints), words (repetition priming), and syntax (structural priming). The persistent nature of these adaptations suggests that they may be a form of implicit learning and connectionist models have been developed which instantiate this hypothesis. Research on implicit learning, however, has also produced evidence that explicit chunk knowledge is involved in the performance of these tasks. In this review, we examine how these interacting implicit and explicit processes may change our understanding of language learning and processing.

Abstract

Messenger ribonucleic acids (RNAs) contain a large number of cis-regulatory RNA elements that function in many types of post-transcriptional regulation. These cis-regulatory elements are often characterized by conserved structures and/or sequences. Although some classes are well known, given the wide range of RNA-interacting proteins in eukaryotes, it is likely that many new classes of cis-regulatory elements are yet to be discovered. An approach to this is to use computational methods that have the advantage of analysing genomic data, particularly comparative data on a large scale. In this study, a set of structural discovery algorithms was applied followed by support vector machine (SVM) classification. We trained a new classification model (CisRNA-SVM) on a set of known structured cis-regulatory elements from 3′-untranslated regions (UTRs) and successfully distinguished these and groups of cis-regulatory elements not been strained on from control genomic and shuffled sequences. The new method outperformed previous methods in classification of cis-regulatory RNA elements. This model was then used to predict new elements from cross-species conserved regions of human 3′-UTRs. Clustering of these elements identified new classes of potential cis-regulatory elements. The model, training and testing sets and novel human predictions are available at: http://mRNA.otago.ac.nz/CisRNA-SVM.

Abstract

This paper investigates the lexical semantics of placement verbs in Mandarin. The majority of Mandarin placement verbs are directional verb compounds (e.g., na2-xia4-lai2 ‘take-descend-come’). They are composed of two or three verbs in a fixed order, each encoding certain semantic components of placement events. The first verb usually conveys object manipulation and the second and the third verbs indicate the Path of motion, including Deixis. The first verb, typically encoding object manipulation, can be semantically general or specific: two general verbs, fang4 ‘put’ and na2 ‘take’, have large but constrained extensional categories, and a number of specific verbs are used based on the Manner of manipulation of the Figure object, the relationship between and the physical properties of Figure and Ground, intentionality of the Agent, and the type of instrument.

Abstract

A significant proportion of children have unexplained problems acquiring proficient linguistic skills despite adequate intelligence and opportunity. Developmental language disorders are highly heritable with substantial societal impact. Molecular studies have begun to identify candidate loci, but much of the underlying genetic architecture remains undetermined. We performed whole-exome sequencing of 43 unrelated probands affected by severe specific language impairment, followed by independent validations with Sanger sequencing, and analyses of segregation patterns in parents and siblings, to shed new light on aetiology. By first focusing on a pre-defined set of known candidates from the literature, we identified potentially pathogenic variants in genes already implicated in diverse language-related syndromes, including ERC1, GRIN2A, and SRPX2. Complementary analyses suggested novel putative candidates carrying validated variants which were predicted to have functional effects, such as OXR1, SCN9A and KMT2D. We also searched for potential “multiple-hit” cases; one proband carried a rare AUTS2 variant in combination with a rare inherited haplotype affecting STARD9, while another carried a novel nonsynonymous variant in SEMA6D together with a rare stop-gain in SYNPR. On broadening scope to all rare and novel variants throughout the exomes, we identified biological themes that were enriched for such variants, including microtubule transport and cytoskeletal regulation.

Abstract

Children adopted early in life into another linguistic community typically forget their birth language but retain, unaware, relevant linguistic knowledge that may facilitate (re)learning of birth-language patterns. Understanding the nature of this knowledge can shed light on how language is acquired. Here, international adoptees from Korea with Dutch as their current language, and matched Dutch-native controls, provided speech production data on a Korean consonantal distinction unlike any Dutch distinctions, at the outset and end of an intensive perceptual training. The productions, elicited in a repetition task, were identified and rated by Korean listeners. Adoptees' production scores improved significantly more across the training period than control participants' scores, and, for adoptees only, relative production success correlated significantly with the rate of learning in perception (which had, as predicted, also surpassed that of the controls). Of the adoptee group, half had been adopted at 17 months or older (when talking would have begun), while half had been prelinguistic (under six months). The former group, with production experience, showed no advantage over the group without. Thus the adoptees' retained knowledge of Korean transferred from perception to production and appears to be abstract in nature rather than dependent on the amount of experience.

Abstract

Until at least 6 mo of age, infants show good discrimination for familiar phonetic contrasts (i.e., those heard in the environmental language) and contrasts that are unfamiliar. Adult-like discrimination (significantly worse for nonnative than for native contrasts) appears only later, by 9–10 mo. This has been interpreted as indicating that infants have no knowledge of phonology until vocabulary development begins, after 6 mo of age. Recently, however, word recognition has been observed before age 6 mo, apparently decoupling the vocabulary and phonology acquisition processes. Here we show that phonological acquisition is also in progress before 6 mo of age. The evidence comes from retention of birth-language knowledge in international adoptees. In the largest ever such study, we recruited 29 adult Dutch speakers who had been adopted from Korea when young and had no conscious knowledge of Korean language at all. Half were adopted at age 3–5 mo (before native-specific discrimination develops) and half at 17 mo or older (after word learning has begun). In a short intensive training program, we observe that adoptees (compared with 29 matched controls) more rapidly learn tripartite Korean consonant distinctions without counterparts in their later-acquired Dutch, suggesting that the adoptees retained phonological knowledge about the Korean distinction. The advantage is equivalent for the younger-adopted and the older-adopted groups, and both groups not only acquire the tripartite distinction for the trained consonants but also generalize it to untrained consonants. Although infants younger than 6 mo can still discriminate unfamiliar phonetic distinctions, this finding indicates that native-language phonological knowledge is nonetheless being acquired at that age.

Abstract

When solving spatial problems, people often spontaneously produce hand gestures. Recent research has shown that our knowledge is shaped by the interaction between our body and the environment. In this article, we review and discuss evidence on: 1) how spontaneous gesture can reveal the development of problem solving strategies when people solve spatial problems; 2) whether producing gestures can enhance spatial problem solving performance. We argue that when solving novel spatial problems, adults go through deagentivization and internalization processes, which are analogous to young children’s cognitive development processes. Furthermore, gesture enhances spatial problem solving performance. The beneficial effect of gesturing can be extended to non-gesturing trials and can be generalized to a different spatial task that shares similar spatial transformation processes.

Abstract

Spontaneous gestures play an important role in spatial problem solving. We investigated the functional role and underlying mechanism of spontaneous gestures in spatial problem solving. In Experiment 1, 132 participants were required to solve a mental rotation task (see Figure 1) without speaking. Participants gestured more frequently in difficult trials than in easy trials. In Experiment 2, 66 new participants were given two identical sets of mental rotation tasks problems, as the one used in experiment 1. Participants who were encouraged to gesture in the first set of mental rotation task problemssolved more problems correctly than those who were allowed to gesture or those who were prohibited from gesturing both in the first set and in the second set in which all participants were prohibited from gesturing. The gestures produced by the gestureencouraged group and the gesture-allowed group were not qualitatively different. In Experiment 3, 32 new participants were first given a set of mental rotation problems and then a second set of nongesturing paper folding problems. The gesture-encouraged group solved more problems correctly in the first set of mental rotation problems and the second set of non-gesturing paper folding problems. We concluded that gesture improves spatial problem solving. Furthermore, gesture has a lasting beneficial effect even when gesture is not available and the beneficial effect is problem-general.We suggested that gesture enhances spatial problem solving by provide a rich sensori-motor representation of the physical world and pick up information that is less readily available to visuo-spatial processes.

Abstract

Koriat (1981) demonstrated that an association from the target to a preceding prime, in the absence of an association from the prime to the target, facilitates lexical decision and referred to this effect as "backward priming". Backward priming is of relevance, because it can provide information about the mechanism underlying semantic priming effects. Following Neely (1991), we distinguish three mechanisms of priming: spreading activation, expectancy, and semantic matching/integration. The goal was to determine which of these mechanisms causes backward priming, by assessing effects of backward priming on a language-relevant ERP component, the N400, and reaction time (RT). Based on previous work, we propose that the N400 priming effect reflects expectancy and semantic matching/integration, but in contrast with RT does not reflect spreading activation. Experiment 1 shows a backward priming effect that is qualitatively similar for the N400 and RT in a lexical decision task. This effect was not modulated by an ISI manipulation. Experiment 2 clarifies that the N400 backward priming effect reflects genuine changes in N400 amplitude and cannot be ascribed to other factors. We will argue that these backward priming effects cannot be due to expectancy but are best accounted for in terms of semantic matching/integration.

Abstract

Expectancy mechanisms are routinely used by the cognitive system in stimulus processing and in anticipation of appropriate responses. Electrophysiology research has documented negative shifts of brain activity when expectancies are violated within a local stimulus context (e.g., reading an implausible word in a sentence) or more globally between consecutive stimuli (e.g., a narrative of images with an incongruent end). In this EEG study, we examine the interaction between expectancies operating at the level of stimulus plausibility and at more global level of contextual congruency to provide evidence for, or against, a disassociation of the underlying processing mechanisms. We asked participants to verify the congruency of pairs of cross-modal stimuli (a sentence and a scene), which varied in plausibility. ANOVAs on ERP amplitudes in selected windows of interest show that congruency violation has longer-lasting (from 100 to 500 ms) and more widespread effects than plausibility violation (from 200 to 400 ms). We also observed critical interactions between these factors, whereby incongruent and implausible pairs elicited stronger negative shifts than their congruent counterpart, both early on (100–200 ms) and between 400–500 ms. Our results suggest that the integration mechanisms are sensitive to both global and local effects of expectancy in a modality independent manner. Overall, we provide novel insights into the interdependence of expectancy during meaning integration of cross-modal stimuli in a verification task

Abstract

Recent game-theoretic simulation and analytical models have demonstrated that cooperative strategies mediated by indicators of cooperative potential, or “tags,” can invade, spread, and resist invasion by noncooperators across a range of population-structure and cost-benefit scenarios. The plausibility of these models is potentially relevant for human evolutionary accounts insofar as humans possess some phenotypic trait that could serve as a reliable tag. Linguistic markers, such as accent and dialect, have frequently been either cursorily defended or promptly dismissed as satisfying the criteria of a reliable and evolutionarily viable tag. This paper integrates evidence from a range of disciplines to develop and assess the claim that speech accent mediated the evolution of tag-based cooperation in humans. Existing evidence warrants the preliminary conclusion that accent markers meet the demands of an evolutionarily viable tag and potentially afforded a cost-effective solution to the challenges of maintaining viable cooperative relationships in diffuse, regional social networks.

Abstract

Common wisdom has it that Buddhism enhances compassion and self-other integration. We put this assumption to empirical test by comparing practicing Taiwanese Buddhists with well-matched atheists. Buddhists showed more evidence of self-other integration in the social Simon task, which assesses the degree to which people co-represent the actions of a coactor. This suggests that self-other integration and task co-representation vary as a function of religious practice.

Abstract

The nature of the connection between musical and spatial processing is controversial. While pitch may be described in spatial terms such as “high” or “low”, it is unclear whether pitch and space are associated but separate dimensions or whether they share representational and processing resources. In the present study, we asked participants to judge whether a target vocal note was the same as (or different from) a preceding cue note. Importantly, target trials were presented as video clips where a singer sometimes gestured upward or downward while singing that target note, thus providing an alternative, concurrent source of spatial information. Our results show that pitch discrimination was significantly biased by the spatial movement in gesture. These effects were eliminated by spatial memory load but preserved under verbal memory load conditions. Together, our findings suggest that pitch and space have a shared representation such that the mental representation of pitch is audiospatial in nature.

Abstract

Past events like fluctuations in population size and post-glacial colonization processes may influence the relative importance of genetic drift, migration and selection when determining the present day patterns of genetic variation. We disentangle how drift, selection and migration shape neutral and adaptive genetic variation in 12 moor frog populations along a 1700 km latitudinal gradient. We studied genetic differentiation and variation at a MHC exon II locus and a set of 18 microsatellites.
Results

Using outlier analyses, we identified the MHC II exon 2 (corresponding to the β-2 domain) locus and one microsatellite locus (RCO8640) to be subject to diversifying selection, while five microsatellite loci showed signals of stabilizing selection among populations. STRUCTURE and DAPC analyses on the neutral microsatellites assigned populations to a northern and a southern cluster, reflecting two different post-glacial colonization routes found in previous studies. Genetic variation overall was lower in the northern cluster. The signature of selection on MHC exon II was weaker in the northern cluster, possibly as a consequence of smaller and more fragmented populations.
Conclusion

Our results show that historical demographic processes combined with selection and drift have led to a complex pattern of differentiation along the gradient where some loci are more divergent among populations than predicted from drift expectations due to diversifying selection, while other loci are more uniform among populations due to stabilizing selection. Importantly, both overall and MHC genetic variation are lower at northern latitudes. Due to lower evolutionary potential, the low genetic variation in northern populations may increase the risk of extinction when confronted with emerging pathogens and climate change.

Abstract

In three experiments, listeners detected vowel or consonant targets in lists of CV syllables constructed from five vowels and five consonants. Responses were faster in a predictable context (e.g., listening for a vowel target in a list of syllables all beginning with the same consonant) than in an unpredictable context (e.g., listening for a vowel target in a list of syllables beginning with different consonants). In Experiment 1, the listeners’ native language was Dutch, in which vowel and consonant repertoires are similar in size. The difference between predictable and unpredictable contexts was comparable for vowel and consonant targets. In Experiments 2 and 3, the listeners’ native language was Spanish, which has four times as many consonants as vowels; here effects of an unpredictable consonant context on vowel detection were significantly greater than effects of an unpredictable vowel context on consonant detection. This finding suggests that listeners’ processing of phonemes takes into account the constitution of their language’s phonemic repertoire and the implications that this has for contextual variability.

Abstract

As the creation of signed language resources is gaining speed world-wide, the need for standards in this field becomes more acute. This paper discusses the state of the field of signed language resources, their metadata descriptions, and annotations that are typically made. It then describes the role that ISOcat may play in this process and how it can stimulate standardisation without imposing standards. Finally, it makes some initial proposals for the thematic domain ‘sign language’ that was introduced in 2011.

Abstract

publication expected April 2012

Abstract

In most of the world, people have regular exposure to multiple accents. Therefore, learning to quickly process accented speech is a prerequisite to successful communication. In this paper, we examine work on the perception of accented speech across the lifespan, from early infancy to late adulthood. Unfamiliar accents initially impair linguistic processing by infants, children, younger adults, and older adults, but listeners of all ages come to adapt to accented speech. Emergent research also goes beyond these perceptual abilities, by assessing links with production and the relative contributions of linguistic knowledge and general cognitive skills. We conclude by underlining points of convergence across ages, and the gaps left to face in future work.

Abstract

Definition Prosocial behavior is any behavior performed by one individual that results in a benefit for another individual. Prosocial motivations, prosocial preferences, or other-regarding preferences refer to the psychological predisposition to behave in the best interest of another individual. A behavior need not be costly to the actor to be considered prosocial, thus the concept is distinct from altruistic behavior which requires that the actor incurs some cost when providing a benefit to another.

Abstract

Researchers have struggled to obtain a clear account of the evolution of prosocial behaviour despite a great deal of recent effort. The aim of this review is to take a brief step back from addressing the question of evolutionary origins of prosocial behaviour in order to identify contextual factors that are contributing to variation in the expression of prosocial behaviour and hindering progress towards identifying phylogenetic patterns. Most available data come from the Primate Order, and the choice of contextual factors to consider was informed by theory and practice, including the nature of the relationship between the potential donor and recipient, the communicative behaviour of the recipients, and features of the prosocial task including whether rewards are visible and whether the prosocial choice creates an inequity between actors. Conclusions are drawn about the facilitating or inhibiting impact of each of these factors on the expression of prosocial behaviour, and areas for future research are highlighted. Acknowledging the impact of these contextual features on the expression of prosocial behaviours should stimulate new research into the proximate mechanisms that drive these effects, yield experimental designs that better control for potential influences on prosocial expression, and ultimately allow progress towards reconstructing the evolutionary origins of prosocial behaviour.

Abstract

The social factors that influence cooperation have remained largely uninvestigated but have the potential to explain much of the variation in cooperative behavior observed in the natural world. We show here that certain dimensions of the social environment, namely the size of the social group, the degree of social tolerance expressed, the structure of the dominance hierarchy, and the patterns of dispersal, may influence the emergence and stability of cooperation in predictable ways. Furthermore, the social environment experienced by a species over evolutionary time will have shaped their cognition to provide certain strengths and strategies that are beneficial in their species‟ social world. These cognitive adaptations will in turn impact the likelihood of cooperating in a given social environment. Experiments with one primate species, the cottontop tamarin, illustrate how social dynamics may influence emergence and stability of cooperative behavior in this species. We then take a more general viewpoint and argue that the hypotheses presented here require further experimental work and the addition of quantitative modeling to obtain a better understanding of how social dynamics influence the emergence and stability of cooperative behavior in complex systems. We conclude by pointing out subsequent specific directions for models and experiments that will allow relevant advances in the understanding of the emergence of cooperation.

Abstract

This study is a comprehensive description of the nominal demonstratives in Dalabon, a severely endangered Gunwinyguan non-Pama-Nyungan language of southwestern Arnhem Land, northern Australia. Demonstratives are attested in the basic vocabulary of every language, yet remain heretofore underdescribed in Australian languages. Traditional definitions of demonstratives as primarily making spatial reference have recently evolved at a great pace, with close analyses of demonstratives-in-use revealing that their use in spatial reference, in narrative discourse, and in interaction is significantly more complex than previously assumed, and that definitions of demonstrative forms are best developed after consideration of their use across these contexts. The present study reinforces findings of complexity in demonstrative use, and the significance of a multidimensional characterization of demonstrative forms. This study is therefore a contribution to the description of Dalabon, to the analysis of demonstratives in Australian languages, and to the theory and typology of demonstratives cross-linguistically. In this study, I present a multi-dimensional analysis of Dalabon demonstratives, using a variety of theoretical frameworks and research tools including descriptive linguistics, lexical-functional grammar, discourse analysis, gesture studies and pragmatics. Using data from personal narratives, improvised interactions and elicitation sessions to investigate the demonstratives, this study takes into account their morphosyntactic distribution, uses in the speech situation, interactional factors, discourse phenomena, concurrent gesture, and uses in personal narratives. I conclude with a unified account of the intenstional and extensional semantics of each form surveyed. The Dalabon demonstrative paradigm divides into two types, those which are spatially-specific and those which are non-spatial. The spatially-specific demonstratives nunda ‘this (in the here-space)’ and djakih ‘that (in the there-space)’ are shown not to encode the location of the referent per se, rather its relative position to dynamic physical and social elements of the speech situation such as the speaker’s engagement area and here-space. Both forms are also used as spatial adverbs to mean ‘here’ and ‘there’ respectively, while only nunda is also used as a temporal adverb ‘now, today’. The spatially-specific demonstratives are limited to situational use in narratives. The non-spatial demonstratives kanh/kanunh ‘that (identifiable)’ and nunh ‘that (unfamiliar, contrastive)’ are used in both the speech situation and personal narratives to index referents as ‘identifiable’ or ‘unfamiliar’ respectively. Their use in the speech situation can conversationally implicate that the referent is distal. The non-spatial demonstratives display the greatest diversity of use in narratives, each specializing for certain uses, yet their wide distribution across discourse usage types can be described on account of their intensional semantics. The findings of greatest typological interest in this study are that speakers’ choice of demonstrative in the speech situation is influenced by multiple simultaneous deictic parameters (including gesture); that oppositions in the Dalabon demonstrative paradigm are not equal, nor exclusively semantic; that the form nunh ‘that (unfamiliar, contrastive)’ is used to index a referent as somewhat inaccessible or unexpected; that the ‘recognitional’ form kanh/kanunh is instead described as ‘identifiable’; and that speakers use demonstratives to index emotional deixis to a referent, or to their addressee.

Abstract

Assimilation of place of articulation across a nasal and a following stop consonant is obligatory in Japanese, but not in Dutch. In four experiments the processing of assimilated forms by speakers of Japanese and Dutch was compared, using a task in which listeners blended pseudo-word pairs such as ranga-serupa. An assimilated blend of this pair would be rampa, an unassimilated blend rangpa. Japanese listeners produced significantly more assimilated than unassimilated forms, both with pseudo-Japanese and pseudo-Dutch materials, while Dutch listeners produced significantly more unassimilated than assimilated forms in each materials set. This suggests that Japanese listeners, whose native-language phonology involves obligatory assimilation constraints, represent the assimilated nasals in nasal-stop sequences as unmarked for place of articulation, while Dutch listeners, who are accustomed to hearing unassimilated forms, represent the same nasal segments as marked for place of articulation.

Abstract

The perceptual processing of speech is a constant interplay of multiple competing albeit convergent processes: acoustic input vs. higher-level representations, universal mechanisms vs. language-specific, veridical traces of speech experience vs. construction and activation of abstract representations. The present summary concerns the third of these issues. The ability to generalise across experience and to deal with resulting abstractions is the hallmark of human cognition, visible even in early infancy. In speech processing, abstract representations play a necessary role in both production and perception. New sorts of evidence are now informing our understanding of the breadth of this role.

Abstract

Rede uitgesproken bij het afscheid als hoogleraar Vergelijkende taalpsychologie aan de Faculteit der Sociale Wetenschappen van de Radboud Universiteit Nijmegen op donderdag 20 september 2012

Abstract

To examine whether lexically stored knowledge about spelling influences phoneme evaluation, we conducted three experiments with a low-level phonetic judgement task: phoneme goodness rating. In each experiment, listeners heard phonetic tokens varying along a continuum centred on /s/, occurring finally in isolated word or nonword tokens. An effect of spelling appeared in Experiment 1: Native English speakers’ goodness ratings for the best /s/ tokens were significantly higher in words spelled with S (e.g., bless) than in words spelled with C (e.g., voice). No such difference appeared when nonnative speakers rated the same materials in Experiment 2, indicating that the difference could not be due to acoustic characteristics of the S- versus C-words. In Experiment 3, nonwords with lexical neighbours consistently spelled with S (e.g., pless) versus with C (e.g., floice) failed to elicit orthographic neighbourhood effects; no significant difference appeared in native English speakers’ ratings for the S-consistent versus the C-consistent sets. Obligatory influence of lexical knowledge on phonemic processing would have predicted such neighbourhood effects; the findings are thus better accommodated by models in which phonemic decisions draw strategically upon lexical information.

Abstract

In English and Dutch, listeners entrain to prosodic contours to predict where focus will fall in an utterance. However, is this strategy universally available, even in languages with different phonological systems? In a phoneme detection experiment, we examined whether prosodic entrainment is also found in Mandarin Chinese, a tone language, where in principle the use of pitch for lexical identity may take precedence over the use of pitch cues to salience. Consistent with the results from Germanic languages, response times were facilitated when preceding intonation predicted accent on the target-bearing word. Acoustic analyses revealed greater F0 range in the preceding intonation of the predicted-accent sentences. These findings have implications for how universal and language-specific mechanisms interact in the processing of salience.

Abstract

Languages contain tens of thousands of words, but these are constructed from a tiny handful of phonetic elements. Consequently, words resemble one another, or can be embedded within one another, a coup stick snot with standing. me process of spoken-word recognition by human listeners involves activation of multiple word candidates consistent with the input, and direct competition between activated candidate words. Further, human listeners are sensitive, at an early, prelexical, stage of speeeh processing, to constraints on what could potentially be a word of the language.

Abstract

Understanding speech in our native tongue seems natural and effortless; listening to speech in a nonnative language is a different experience. In this book, Anne Cutler argues that listening to speech is a process of native listening because so much of it is exquisitely tailored to the requirements of the native language. Her cross-linguistic study (drawing on experimental work in languages that range from English and Dutch to Chinese and Japanese) documents what is universal and what is language specific in the way we listen to spoken language. Cutler describes the formidable range of mental tasks we carry out, all at once, with astonishing speed and accuracy, when we listen. These include evaluating probabilities arising from the structure of the native vocabulary, tracking information to locate the boundaries between words, paying attention to the way the words are pronounced, and assessing not only the sounds of speech but prosodic information that spans sequences of sounds. She describes infant speech perception, the consequences of language-specific specialization for listening to other languages, the flexibility and adaptability of listening (to our native languages), and how language-specificity and universality fit together in our language processing system. Drawing on her four decades of work as a psycholinguist, Cutler documents the recent growth in our knowledge about how spoken-word recognition works and the role of language structure in this process. Her book is a significant contribution to a vibrant and rapidly developing field.

Abstract

The way we listen to spoken language is tailored to the specific benefit of native-language speech input. Listening to speech in non-native languages can be significantly hindered by this native bias. Is it possible to determine the degree to which a listener is listening in a native-like manner? Promising indications of how this question may be tackled are provided by new research findings concerning the great flexibility that characterises listening to the L1, in online adjustment of phonetic category boundaries for adaptation across talkers, and in modulation of lexical dynamics for adjustment across listening conditions. This flexibility pays off in many dimensions, including listening in noise, adaptation across dialects, and identification of voices. These findings further illuminate the robustness and flexibility of native listening, and potentially point to ways in which we might begin to assess degrees of ‘native-likeness’ in this skill.

Abstract

The phoneme detection task is widely used in spoken word recognition research. Alphabetically literate participants, however, are more used to explicit representations of letters than of phonemes. The present study explored whether phoneme detection is sensitive to how target phonemes are, or may be, orthographically realised. Listeners detected the target sounds [b,m,t,f,s,k] in word-initial position in sequences of isolated English words. Response times were faster to the targets [b,m,t], which have consistent word-initial spelling, than to the targets [f,s,k], which are inconsistently spelled, but only when listeners’ attention was drawn to spelling by the presence in the experiment of many irregularly spelled fillers. Within the inconsistent targets [f,s,k], there was no significant difference between responses to targets in words with majority and minority spellings. We conclude that performance in the phoneme detection task is not necessarily sensitive to orthographic effects, but that salient orthographic manipulation can induce such sensitivity.

Abstract

Studies of spoken-word recognition have revealed that competition from embedded words differs in strength as a function of where in the carrier word the embedded word is found and have further shown embedding patterns to be skewed such that embeddings in initial position in carriers outnumber embeddings in final position. Lexico-statistical analyses show that this skew is highly attenuated in Japanese, a noninflectional language. Comparison of the extent of the asymmetry in the three Germanic languages English, Dutch, and German allows the source to be traced to a combination of suffixal morphology and vowel reduction in unstressed syllables.

Abstract

We show that Atkinson’s (Reports, 15 April 2011, p. 346) intriguing proposal—that global
linguistic diversity supports a single language origin in Africa—is an artifact of using suboptimal
data, biased methodology, and unjustified assumptions. We criticize his approach using more
suitable data, and we additionally provide new results suggesting a more complex scenario for the
emergence of global linguistic diversity.

Abstract

Evidence from certain geographical areas links lymphomas of the ocular adnexa marginal zone B-cell lymphomas (OAMZL) with Chlamydophila psittaci (Cp) infection, suggesting that lymphoma development is dependent upon chronic stimulation by persistent infections. Notwithstanding that, the actual immunopathogenetical mechanisms have not yet been elucidated. As in other B-cell lymphomas, insight into this issue, especially with regard to potential selecting ligands, could be provided by analysis of the immunoglobulin (IG) receptors of the malignant clones. To this end, we studied the molecular features of IGs in 44 patients with OAMZL (40% Cp-positive), identifying features suggestive of a pathogenic mechanism of autoreactivity. Herein, we show that lymphoma cells express a distinctive IG repertoire, with electropositive antigen (Ag)-binding sites, reminiscent of autoantibodies (auto-Abs) recognizing DNA. Additionally, five (11%) cases of OAMZL expressed IGs homologous with autoreactive Abs or IGs of patients with chronic lymphocytic leukemia, a disease known for the expression of autoreactive IGs by neoplastic cells. In contrast, no similarity with known anti-Chlamydophila Abs was found. Taken together, these results strongly indicate that OAMZL may originate from B cells selected for their capability to bind Ags and, in particular, auto-Ags. In OAMZL associated with Cp infection, the pathogen likely acts indirectly on the malignant B cells, promoting the development of an inflammatory milieu, where auto-Ags could be exposed and presented, driving proliferation and expansion of self-reactive B cells.

Abstract

Speech-in-speech perception can be challenging because the processing of competing acoustic and linguistic information leads to informational masking. Here, a method is proposed to isolate the linguistic component of informational masking while keeping the distractor's acoustic information unchanged. Participants performed a dichotic listening cocktail-party task before and after training on 4-band noise-vocoded sentences that became intelligible through the training. Distracting noise-vocoded speech interfered more with target speech comprehension after training (i.e., when intelligible) than before training (i.e., when unintelligible) at −3 dB SNR. These findings confirm that linguistic and acoustic information have distinct masking effects during speech-in‐speech comprehension

Abstract

The Battery for the Assessment of Auditory Sensorimotor and Timing Abilities (BAASTA) is a new tool for the systematic assessment of perceptual and sensorimotor timing skills. It spans a broad range of timing skills aimed at differentiating individual timing profiles. BAASTA consists of sensitive time perception and production tasks. Perceptual tasks include duration discrimination, anisochrony detection (with tones and music), and a version of the Beat Alignment Task. Perceptual thresholds for duration discrimination and anisochrony detection are estimated with a maximum likelihood procedure (MLP) algorithm. Production tasks use finger tapping and include unpaced and paced tapping (with tones and music), synchronization-continuation, and adaptive tapping to a sequence with a tempo change. BAASTA was tested in a proof-of-concept study with 20 non-musicians (Experiment 1). To validate the results of the MLP procedure, less widespread than standard staircase methods, three perceptual tasks of the battery (duration discrimination, anisochrony detection with tones, and with music) were further tested in a second group of non-musicians using 2 down / 1 up and 3 down / 1 up staircase paradigms (n = 24) (Experiment 2). The results show that the timing profiles provided by BAASTA allow to detect cases of timing/rhythm disorders. In addition, perceptual thresholds yielded by the MLP algorithm, although generally comparable to the results provided by standard staircase, tend to be slightly lower. In sum, BAASTA provides a comprehensive battery to test perceptual and sensorimotor timing skills, and to detect timing/rhythm deficits.

Abstract

The morphosyntactic paradigm of an inflected word can influence isolated word recognition, but its role in multiple-word phrasal integration is less clear. We examined the electrophysiological response to adjectives in short German prepositional phrases to evaluate whether strong and weak forms of the adjective show a differential response, and whether paradigm variables are related to this response. Twenty native German speakers classified serially presented phrases as grammatically correct or not while the electroencephalogram (EEG) was recorded. A functional mixed effects model of the response to grammatically correct trials revealed a differential response to strong and weak forms of the adjectives. This response difference depended on whether the preceding preposition imposed accusative or dative case. The lexically conditioned information content of the adjectives modulated a later interval of the response. The results indicate that grammatical context modulates the response to morphosyntactic information content, and lends support to the role of paradigm structure in integrative phrasal processing.

Abstract

Language is the best example of a cultural evolutionary system, able to retain a phylogenetic signal over many thousands of years. The temporal stability (conservatism) of basic vocabulary is relatively well understood, but the stability of the structural properties of language (phonology, morphology, syntax) is still unclear. Here we report an extensive Bayesian phylogenetic investigation of the structural stability of numerous features across many language families and we introduce a novel method for analyzing the relationships between the “stability profiles” of language families. We found that there is a strong universal component across language families, suggesting the existence of universal linguistic, cognitive and genetic constraints. Against this background, however, each language family has a distinct stability profile, and these profiles cluster by geographic area and likely deep genealogical relationships. These stability profiles reveal, for example, the ancient historical relationships between the Siberian and American language families, presumed to be separated by at least 12,000 years. Thus, such higher-level properties of language seen as an evolutionary system might allow the investigation of ancient connections between languages and shed light on the peopling of the world.

Abstract

Commentary on Cohen, E. (2012). The evolution of tag-based cooperation in humans: The case for accent. Current Anthropology, 53, 588-616. doi:10.1086/667654.

Abstract

Language is not a purely cultural phenomenon somehow isolated from its wider environment, and we may only understand its origins and evolution by seriously considering its embedding in this environment as well as its multimodal nature. By environment here we understand other aspects of culture (such as communication technology, attitudes towards language contact, etc.), of the physical environment (ultraviolet light incidence, air humidity, etc.), and of the biological infrastructure for language and speech. We are specifically concerned in this paper with the latter, in the form of the biases, constraints and affordances that the anatomy and physiology of the vocal tract create on speech and language. In a nutshell, our argument is that (a) there is an under-appreciated amount of inter-individual variation in vocal tract (VT) anatomy and physiology, (b) variation that is non-randomly distributed across populations, and that (c) results in systematic differences in phonetics and phonology between languages. Relevant differences in VT anatomy include the overall shape of the hard palate, the shape of the alveolar ridge, the relationship between the lower and upper jaw, to mention just a few, and our data offer a new way to systematically explore such differences and their potential impact on speech. These differences generate very small biases that nevertheless can be amplified by the repeated use and transmission of language, affecting language diachrony and resulting in cross-linguistic synchronic differences. Moreover, the same type of biases and processes might have played an essential role in the emergence and evolution of language, and might allow us a glimpse into the speech and language of extinct humans by, for example, reconstructing the anatomy of parts of their vocal tract from the fossil record and extrapolating the biases we find in present-day humans.

Abstract

People automatically chunk ongoing dynamic events into discrete units. This paper investigates whether linguistic structure is a factor in this process. We test the claim that describing an event with a serial verb construction will influence a speaker’s conceptual event structure. The grammar of Avatime (a Kwa language spoken in Ghana)requires its speakers to describe some, but not all, placement events using a serial verb construction which also encodes the preceding taking event. We tested Avatime and English speakers’ recognition memory for putting and taking events. Avatime speakers were more likely to falsely recognize putting and taking events from episodes associated with takeput serial verb constructions than from episodes associated with other constructions. English speakers showed no difference in false recognitions between episode types. This demonstrates that memory for episodes is related to the type of language used; and, moreover, across languages different conceptual representations are formed for the same physical episode, paralleling habitual linguistic practices

Abstract

Speakers choose a particular expression based on many factors, including availability of the referent in the perceptual context. We examined whether, when expressing referents, monolingual English- and Turkish-speaking children: (1) are sensitive to perceptual context, (2) express this sensitivity in language-specific ways, and (3) use co-speech gestures to specify referents that are underspecified. We also explored the mechanisms underlying children's sensitivity to perceptual context. Children described short vignettes to an experimenter under two conditions: The characters in the vignettes were present in the perceptual context (perceptual context); the characters were absent (no perceptual context). Children routinely used nouns in the no perceptual context condition, but shifted to pronouns (English-speaking children) or omitted arguments (Turkish-speaking children) in the perceptual context condition. Turkish-speaking children used underspecified referents more frequently than English-speaking children in the perceptual context condition; however, they compensated for the difference by using gesture to specify the forms. Gesture thus gives children learning structurally different languages a way to achieve comparable levels of specification while at the same time adhering to the referential expressions dictated by their language.

Abstract

Abnormal prosody is a striking feature of the speech of those with Autism Spectrum Disorder (ASD), but previous reports suggest large variability among those with ASD. Here we show that part of this heterogeneity can be explained by level of language functioning. We recorded semi-spontaneous but controlled conversations in adults with and without Autism Spectrum Disorder and measured features related to pitch and duration to determine (1) general use of prosodic features, (2) prosodic use in relation to marking information structure, specifically, the emphasis of new information in a sentence (focus) as opposed to information already given in the conversational context (topic), and (3) the relation between prosodic use and level of language function. We found that, compared to typical adults, those with ASD with high language functioning generally used a larger pitch range than controls but did not mark information structure, whereas those with moderate language functioning generally used a smaller pitch range than controls but marked information structure appropriately to a large extent. Both impaired general prosodic use and impaired marking of information structure would be expected to seriously impact social communication and thereby lead to increased difficulty in personal domains, such as making and keeping friendships, and in professional domains, such as competing for employment opportunities.

Abstract

Investigation of the biological basis of human speech and language is being transformed by developments in molecular technologies, including high-throughput genotyping and next-generation sequencing of whole genomes. These advances are shedding new light on the genetic architecture underlying language-related disorders (speech apraxia, specific language impairment, developmental dyslexia) as well as that contributing to variation in relevant skills in the general population. We discuss how state-of-the-art methods are uncovering a range of genetic mechanisms, from rare mutations of large effect to common polymorphisms that increase risk in a subtle way, while converging on neurogenetic pathways that are shared between distinct disorders. We consider the future of the field, highlighting the unusual challenges and opportunities associated with studying genomics of language-related traits.

Abstract

Background: Human fibroblasts can be directly converted to several subtypes of neurons, but cortical projection neurons have not been generated. Methods: Here we screened for transcription factor combinations that could potentially convert human fibroblasts to functional excitatory cortical neurons. The induced cortical (iCtx) cells were analyzed for cortical neuronal identity using immunocytochemistry, single-cell quantitative polymerase chain reaction (qPCR), electrophysiology, and their ability to integrate into human neural networks in vitro and ex vivo using electrophysiology and rabies virus tracing. Results: We show that a combination of three ranscription fact ors, BRN2, MYT1L, and FEZF2, have the ability to directly convert human fibroblasts to functional excitatory cortical neurons. The conversion efficiency was increased to about 16% by treatment with small molecules and microRNAs. The iCtx cells exhibited electrophysiological properties of functional neurons, had pyramidal-like cell morphology, and expressed key cortical projection neuronal markers. Single-cell analysis of iCtx cells revealed a complex gene expression profile, a subpopulation of them displaying a molecular signature closely resembling that of human fetal primary cortical neurons. The iCtx cells received synaptic inputs from co-cultured human fetal primary cortical neurons, contained spines, and expressed the postsyna ptic excitatory scaffold protein PSD95. When transplanted ex vivo to organotypic cultures of adult human cerebral cortex, the iCtx cells exhibited morphological and electrophysiological properties of mature neurons, integrated structurally into the cortical tissue, and received synaptic inputs from adult human neurons. Conclusions: Our findings indicate that functional excitatory cortical neurons, generated here for the first time by direct conversion of human somatic cells, have the capacity for synaptic integration into adult human cortex.

Abstract

Developmental dyslexia, a severe and persistent reading and spelling impairment, is characterized by difficulties in processing speech sounds (i.e., phonemes). Here, we test the hypothesis that these phonological difficulties are associated with a dysfunction of the auditory sensory thalamus, the medial geniculate body (MGB). By using functional MRI, we found that, in dyslexic adults, the MGB responded abnormally when the task required attending to phonemes compared with other speech features. No other structure in the auditory pathway showed distinct functional neural patterns between the two tasks for dyslexic and control participants. Furthermore, MGB activity correlated with dyslexia diagnostic scores, indicating that the task modulation of the MGB is critical for performance in dyslexics. These results suggest that deficits in dyslexia are associated with a failure of the neural mechanism that dynamically tunes MGB according to predictions from cortical areas to optimize speech processing. This view on task-related MGB dysfunction in dyslexics has the potential to reconcile influential theories of dyslexia within a predictive coding framework of brain function.

Abstract

The extent to which the phonetic system of a second language is mastered varies across individuals. The present study evaluates the pattern of individual differences in late bilinguals across different phonological processes. Fifty-five late Dutch-English bilinguals were tested on their ability to perceive a difficult L2 speech contrast (the English /æ/-/ε/ contrast) in three different tasks: A categorization task, a word identification task and a lexical decision task. As a group, L2 listeners were less accurate than native listeners. However, at the individual level, almost half of the L2 listeners scored within the native range in the categorization task whereas a small percentage scored within the native range in the identification and lexical decision tasks. These results show that L2 listeners' performance crucially depends on the nature of the task, with higher L2 listener accuracy on an acoustic-phonetic analysis task than on tasks involving lexical processes. These findings parallel previous results for early bilinguals, where the pattern of performance was consistent with the processing hierarchy proposed by different models of speech perception. The results indicate that the analysis of patterns of non-native performance can provide important insights concerning the architecture of the speech perception system and the issue of language learnability.

Abstract

Prosody, particularly accent, aids comprehension by drawing attention to important elements such as the information that answers a question. A study using ERP registration investigated how the brain deals with the interpretation of prosodic prominence. Sentences were embedded in short dialogues and contained accented elements that were congruous or incongruous with respect to a preceding question. In contrast to previous studies, no explicit prosodic judgment task was added. Robust effects of accentuation were evident in the form of an “accent positivity” (200–500 msec) for accented elements irrespective of their congruity. Our results show that incongruously accented elements, that is, superfluous accents, activate a specific set of neural systems that is inactive in case of incongruously unaccented elements, that is, missing accents. Superfluous accents triggered an early positivity around 100 msec poststimulus, followed by a right-lateralized negative effect (N400). This response suggests that redundant information is identified immediately and leads to the activation of a neural system that is associated with semantic processing (N400). No such effects were found when contextually expected accents were missing. In a later time window, both missing and superfluous accents triggered a late positivity on midline electrodes, presumably related to making sense of both kinds of mismatching stimuli. These results challenge previous findings of greater processing for missing accents and suggest that the natural processing of prosody involves a set of distinct, temporally organized neural systems.

Abstract

The present dissertation investigates what neurocognitive processes are activated in the brain when listeners comprehend spoken language and in particular the melody and rhythm of speech, also referred to as prosody. The findings of several electrophysiological studies show that prosody influences the early and late stages of spoken language processing. When words are accented, listeners consider them important, and the brain responds to accentuation already 200 milliseconds after stimulus onset. The processing of prosodic prominence occurs whether or not a context is present and whether or not accent is congruent with context, although the responses to accentuation may be modified by either of these factors and by the focus particle only. Listeners are sensitive not only to the presence of prosodic prominence but also to the type of accents speakers use: corrective prosody activates additional interpretation mechanisms related to the construction of corrective meaning. The parallel between accents across clauses impacts the disambiguation of sentences with verb ellipsis. By interpreting prosodically parallel elements as syntactically parallel, listeners arrive at less preferred interpretations of conjoined clauses. The research indentifies early correlates of incongruous prosody in strongly predictive contexts as well as late integration processes for prosody comprehension, which are related to the processing of structural complexity in isolated and ambiguous sentences. The dissertation provides evidence that the brain is sensitive to differences in prosody even in the absence of prosodic judgment. However, by changing the task, one modulates the neural mechanisms of prosody processing.

Abstract

Brain-to-brain interfaces, in which brains are physically connected without the intervention of language, promise new ways of collaboration and communication between humans. I examine the narrow view of language implicit in current conceptions of brain-to-brain interfaces and put forward a constructive alternative, stressing the role of language in organising joint agency. Two features of language stand out as crucial: its selectivity, which provides people with much-needed filters between public words and private worlds; and its negotiability, which provides people with systematic opportunities for calibrating understanding and expressing consent and dissent. Without these checks and balances, brain-to-brain interfaces run the risk of reducing people to the level of amoeba in a slime mold; with them, they may mature to become useful extensions of human agency

Abstract

We present a new transcription mode for the annotation tool ELAN. This mode is designed to speed up the process of creating transcriptions of primary linguistic data (video and/or audio recordings of linguistic behaviour). We survey the basic transcription workflow of some commonly used tools (Transcriber, BlitzScribe, and ELAN) and describe how the new transcription interface improves on these existing implementations. We describe the design of the transcription interface and explore some further possibilities for improvement in the areas of segmentation and computational enrichment of annotations.

Abstract

Ideophones are marked words that depict sensory imagery found in many of the world’s languages. They are noted for their special forms, distinct grammatical behaviour, rich sensory meanings, and interactional uses related to experience and evidentiality. This review surveys recent developments in ideophone research. Work on the semiotics of ideophones helps explain why they are marked and how they realise the depictive potential of speech. A true semantic typology of ideophone systems is coming within reach through a combination of language-internal analyses and language-independent elicitation tools. Documentation of ideophones in a wide variety of genres as well as sequential analysis of ideophone use in natural discourse leads to new insights about their interactional uses and about their relation to other linguistic devices like reported speech and grammatical evidentials. As the study of ideophones is coming of age, it sheds new light on what is possible and probable in human language.

Abstract

Words and phrases may differ in the extent to which they are susceptible to prosodic foregrounding and expressive morphology: their expressiveness. They may also differ in the degree to which they are integrated in the morphosyntactic structure of the utterance: their grammatical integration. We describe an inverse relation that holds across widely varied languages, such that more expressiveness goes together with less grammatical integration, and vice versa. We review typological evidence for this inverse relation in 10 languages, then quantify and explain it using Japanese corpus data. We do this by tracking ideophones —vivid sensory words also known as mimetics or expressives— across different morphosyntactic contexts and measuring their expressiveness in terms of intonation, phonation and expressive morphology. We find that as expressiveness increases, grammatical integration decreases. Using gesture as a measure independent of the speech signal, we find that the most expressive ideophones are most likely to come together with iconic gestures. We argue that the ultimate cause is the encounter of two distinct and partly incommensurable modes of representation: the gradient, iconic, depictive system represented by ideophones and iconic gestures and the discrete, arbitrary, descriptive system represented by ordinary words. The study shows how people combine modes of representation in speech and demonstrates the value of integrating description and depiction into the scientific vision of language.

Abstract

Mensen groeien op in verschillende omgevingen, met verschillende ervaringen en verschillende talen. Betekent dat ook dat ze verschillend denken? En als er invloed is van taal op denken, hoe ver reikt die dan? Wordt ons denken begrensd door woorden, of is de invloed meer gematigd en kunnen we er soms zelfs aan ontkomen?

Abstract

Ideophones are often described as words that are highly expressive and morphosyntactically marginal. A study of ideophones in everyday conversations in Siwu (Kwa, eastern Ghana) reveals a landscape of variation and change that sheds light on some larger questions in the morphosyntactic typology of ideophones. The article documents a trade-off between expressiveness and morphosyntactic integration, with high expressiveness linked to low integration and vice versa. It also describes a pathway for deideophonisation and finds that frequency of use is a factor that influences the degree to which ideophones can come to be more like ordinary words. The findings have implications for processes of (de)ideophonisation, ideophone borrowing, and ideophone typology. A key point is that the internal diversity we find in naturally occurring data, far from being mere noise, is patterned variation that can help us to get a handle on the factors shaping ideophone systems within and across languages.

Abstract

Linguistic discovery is viewpoint-dependent, just like our ideas about what is marginal and what is central in language. In this essay I consider two supposed marginalia —ideophones and interjections— which provide some useful pointers for widening our field of view. Ideophones challenge us to take a fresh look at language and consider how it is that our communication system combines multiple modes of representation. Interjections challenge us to extend linguistic inquiry beyond sentence level, and remind us that language is social-interactive at core. Marginalia, then, are not the obscure, exotic phenomena that can be safely ignored: they represent opportunities for innovation and invite us to keep pushing the edges of linguistic inquiry.

Abstract

People often begin stories in conversation by referring to person, time, and place. We study story beginnings in three societies and find place reference is recurrently used to (i) set the stage, foreshadowing the type of story and the kind of response due, and to (ii) make the story cohere, anchoring elements of the developing story. Recipients orient to these interactional affordances of place reference by responding in ways that attend to the relevance of place for the story and by requesting clarification when references are incongruent or noticeably absent. The findings are based on 108 story beginnings in three unrelated languages: Cha’palaa, a Barbacoan language of Ecuador; Northern Italian, a Romance language of Italy; and Siwu, a Kwa language of Ghana. The commonalities suggest we have identified generic affordances of place reference, and that storytelling in conversation offers a robust sequential environment for systematic comparative research on conversational structures.

Abstract

The widespread occurrence of ideophones, large classes of words specialized in evoking sensory imagery, is little known outside linguistics and anthropology. Ideophones are a common feature in many of the world’s languages but are underdeveloped in English and other Indo-European languages. Here we study the meanings of ideophones in Siwu (a Kwa language from Ghana) using a pile-sorting task. The goal was to uncover the underlying structure of the lexical space and to examine the claimed link between ideophones and perception. We found that Siwu ideophones are principally organized around fine-grained aspects of sensory perception, and map onto salient psychophysical dimensions identified in sensory science. The results ratify ideophones as dedicated sensory vocabulary and underline the relevance of ideophones for research on language and perception.

Abstract

People often talk about musical pitch in terms of spatial metaphors. In English, for instance, pitches can be high or low, whereas in other languages pitches are described as thick or thin. According to psychophysical studies, metaphors in language can also shape people’s nonlinguistic space-pitch representations. But does language establish mappings between space and pitch in the first place or does it modify preexisting associations? Here we tested 4-month-old Dutch infants’ sensitivity to height-pitch and thickness-pitch mappings in two preferential looking tasks. Dutch infants looked significantly longer at cross-modally congruent stimuli in both experiments, indicating that infants are sensitive to space-pitch associations prior to language. This early presence of space-pitch mappings suggests that these associations do not originate from language. Rather, language may build upon pre-existing mappings and change them gradually via some form of competitive associative learning.

Abstract

Responding to similarity, difference, and relative magnitude (SDM) is ubiquitous in the animal kingdom. However, humans seem unique in the ability to represent relative magnitude (‘more’/‘less’) and similarity (‘same’/‘different’) as abstract relations that take arguments (e.g., greater-than (x,y)). While many models use structured relational representations of magnitude and similarity, little progress has been made on how these representations arise. Models that developuse these representations assume access to computations of similarity and magnitude a priori, either encoded as features or as output of evaluation operators. We detail a mechanism for producing invariant responses to “same”, “different”, “more”, and “less” which can be exploited to compute similarity and magnitude as an evaluation operator. Using DORA (Doumas, Hummel, & Sandhofer, 2008), these invariant responses can serve be used to learn structured relational representations of relative magnitude and similarity from pixel images of simple shapes

Abstract

Purpose This study investigated whether and to what extent iconic co-speech gestures contribute to information from visible speech to enhance degraded speech comprehension at different levels of noise-vocoding. Previous studies of the contributions of these 2 visual articulators to speech comprehension have only been performed separately.

Method Twenty participants watched videos of an actress uttering an action verb and completed a free-recall task. The videos were presented in 3 speech conditions (2-band noise-vocoding, 6-band noise-vocoding, clear), 3 multimodal conditions (speech + lips blurred, speech + visible speech, speech + visible speech + gesture), and 2 visual-only conditions (visible speech, visible speech + gesture).

Results Accuracy levels were higher when both visual articulators were present compared with 1 or none. The enhancement effects of (a) visible speech, (b) gestural information on top of visible speech, and (c) both visible speech and iconic gestures were larger in 6-band than 2-band noise-vocoding or visual-only conditions. Gestural enhancement in 2-band noise-vocoding did not differ from gestural enhancement in visual-only conditions.

Abstract

This paper summarizes the results of a descriptive syntactic category analysis of child English no which reveals that young children use and represent no as a determiner and negatives like no pen as NPs, contra standard analyses.