Publications

Displaying 1 - 100 of 512
  • Abma, R., Breeuwsma, G., & Poletiek, F. H. (2001). Toetsen in het onderwijs. De Psycholoog, 36, 638-639.
  • Acheson, D. J., & Hagoort, P. (2014). Twisting tongues to test for conflict monitoring in speech production. Frontiers in Human Neuroscience, 8: 206. doi:10.3389/fnhum.2014.00206.

    Abstract

    A number of recent studies have hypothesized that monitoring in speech production may occur via domain-general mechanisms responsible for the detection of response conflict. Outside of language, two ERP components have consistently been elicited in conflict-inducing tasks (e.g., the flanker task): the stimulus-locked N2 on correct trials, and the response-locked error-related negativity (ERN). The present investigation used these electrophysiological markers to test whether a common response conflict monitor is responsible for monitoring in speech and non-speech tasks. Electroencephalography (EEG) was recorded while participants performed a tongue twister (TT) task and a manual version of the flanker task. In the TT task, people rapidly read sequences of four nonwords arranged in TT and non-TT patterns three times. In the flanker task, people responded with a left/right button press to a center-facing arrow, and conflict was manipulated by the congruency of the flanking arrows. Behavioral results showed typical effects of both tasks, with increased error rates and slower speech onset times for TT relative to non-TT trials and for incongruent relative to congruent flanker trials. In the flanker task, stimulus-locked EEG analyses replicated previous results, with a larger N2 for incongruent relative to congruent trials, and a response-locked ERN. In the TT task, stimulus-locked analyses revealed broad, frontally-distributed differences beginning around 50 ms and lasting until just before speech initiation, with TT trials more negative than non-TT trials; response-locked analyses revealed an ERN. Correlation across these measures showed some correlations within a task, but little evidence of systematic cross-task correlation. Although the present results do not speak against conflict signals from the production system serving as cues to self-monitoring, they are not consistent with signatures of response conflict being mediated by a single, domain-general conflict monitor
  • Adank, P., Smits, R., & Van Hout, R. (2004). A comparison of vowel normalization procedures for language variation research. Journal of the Acoustical Society of America, 116(5), 3099-3109. doi:10.1121/1.1795335.

    Abstract

    An evaluation of vowel normalization procedures for the purpose of studying language variation is presented. The procedures were compared on how effectively they (a) preserve phonemic information, (b) preserve information about the talker's regional background (or sociolinguistic information), and (c) minimize anatomical/physiological variation in acoustic representations of vowels. Recordings were made for 80 female talkers and 80 male talkers of Dutch. These talkers were stratified according to their gender and regional background. The normalization procedures were applied to measurements of the fundamental frequency and the first three formant frequencies for a large set of vowel tokens. The normalization procedures were evaluated through statistical pattern analysis. The results show that normalization procedures that use information across multiple vowels ("vowel-extrinsic" information) to normalize a single vowel token performed better than those that include only information contained in the vowel token itself ("vowel-intrinsic" information). Furthermore, the results show that normalization procedures that operate on individual formants performed better than those that use information across multiple formants (e.g., "formant-extrinsic" F2-F1).
  • Adank, P., Van Hout, R., & Smits, R. (2004). An acoustic description of the vowels of Northern and Southern Standard Dutch. Journal of the Acoustical Society of America, 116(3), 1729-1738. doi:10.1121/1.1779271.
  • Agus, T., Carrion Castillo, A., Pressnitzer, D., & Ramus, F. (2014). Perceptual learning of acoustic noise by individuals with dyslexia. Journal of Speech, Language, and Hearing Research., 57, 1069-1077. doi:10.1044/1092-4388(2013/13-0020).

    Abstract

    Purpose: A phonological deficit is thought to affect most individuals with developmental dyslexia. The present study addresses whether the phonological deficit is caused by difficulties with perceptual learning of fine acoustic details. Method: A demanding test of nonverbal auditory memory, “noise learning,” was administered to both adults with dyslexia and control adult participants. On each trial, listeners had to decide whether a stimulus was a 1-s noise token or 2 abutting presentations of the same 0.5-s noise token (repeated noise). Without the listener’s knowledge, the exact same noise tokens were presented over many trials. An improved ability to perform the task for such “reference” noises reflects learning of their acoustic details. Results: Listeners with dyslexia did not differ from controls in any aspect of the task, qualitatively or quantitatively. They required the same amount of training to achieve discrimination of repeated from nonrepeated noises, and they learned the reference noises as often and as rapidly as the control group. However, they did show all the hallmarks of dyslexia, including a well-characterized phonological deficit. Conclusion: The data did not support the hypothesis that deficits in basic auditory processing or nonverbal learning and memory are the cause of the phonological deficit in dyslexia
  • Alday, P. M., Schlesewsky, M., & Bornkessel-Schlesewsky, I. (2014). Towards a Computational Model of Actor-Based Language Comprehension. Neuroinformatics, 12(1), 143-179. doi:10.1007/s12021-013-9198-x.

    Abstract

    Neurophysiological data from a range of typologically diverse languages provide evidence for a cross-linguistically valid, actor-based strategy of understanding sentence-level meaning. This strategy seeks to identify the participant primarily responsible for the state of affairs (the actor) as quickly and unambiguously as possible, thus resulting in competition for the actor role when there are multiple candidates. Due to its applicability across languages with vastly different characteristics, we have proposed that the actor strategy may derive from more basic cognitive or neurobiological organizational principles, though it is also shaped by distributional properties of the linguistic input (e.g. the morphosyntactic coding strategies for actors in a given language). Here, we describe an initial computational model of the actor strategy and how it interacts with language-specific properties. Specifically, we contrast two distance metrics derived from the output of the computational model (one weighted and one unweighted) as potential measures of the degree of competition for actorhood by testing how well they predict modulations of electrophysiological activity engendered by language processing. To this end, we present an EEG study on word order processing in German and use linear mixed-effects models to assess the effect of the various distance metrics. Our results show that a weighted metric, which takes into account the weighting of an actor-identifying feature in the language under consideration outperforms an unweighted distance measure. We conclude that actor competition effects cannot be reduced to feature overlap between multiple sentence participants and thereby to the notion of similarity-based interference, which is prominent in current memory-based models of language processing. Finally, we argue that, in addition to illuminating the underlying neurocognitive mechanisms of actor competition, the present model can form the basis for a more comprehensive, neurobiologically plausible computational model of constructing sentence-level meaning.
  • Alferink, I., & Gullberg, M. (2014). French-Dutch bilinguals do not maintain obligatory semantic distinctions: Evidence from placement verbs. Bilingualism: Language and Cognition, 17, 22-37. doi:10.1017/S136672891300028X.

    Abstract

    It is often said that bilinguals are not the sum of two monolinguals but that bilingual systems represent a third pattern. This study explores the exact nature of this pattern. We ask whether there is evidence of a merged system when one language makes an obligatory distinction that the other one does not, namely in the case of placement verbs in French and Dutch, and whether such a merged system is realised as a more general or a more specific system. The results show that in elicited descriptions Belgian French-Dutch bilinguals drop one of the categories in one of the languages, resulting in a more general semantic system in comparison with the non-contact variety. They do not uphold the obligatory distinction in the verb nor elsewhere despite its communicative relevance. This raises important questions regarding how widespread these differences are and what drives these patterns
  • Allen, G. L., Kirasic, K. C., Rashotte, M. A., & Haun, D. B. M. (2004). Aging and path integration skill: Kinesthetic and vestibular contributions to wayfinding. Perception & Psychophysics, 66(1), 170-179.

    Abstract

    In a triangle completion task designed to assess path integration skill, younger and older adults performed
    similarly after being led, while blindfolded, along the route segments on foot, which provided both kinesthetic and vestibular information about the outbound path. In contrast, older adults’ performance was impaired, relative to that of younger adults, after they were conveyed, while blindfolded,
    along the route segments in a wheelchair, which limited them principally to vestibular information.
    Correlational evidence suggested that cognitive resources were significant factors in accounting for age-related decline in path integration performance.
  • Ambridge, B., Pine, J. M., Rowland, C. F., Freudenthal, D., & Chang, F. (2014). Avoiding dative overgeneralisation errors: semantics, statistics or both? Language, Cognition and Neuroscience, 29(2), 218-243. doi:10.1080/01690965.2012.738300.

    Abstract

    How do children eventually come to avoid the production of overgeneralisation errors, in particular, those involving the dative (e.g., *I said her “no”)? The present study addressed this question by obtaining from adults and children (5–6, 9–10 years) judgements of well-formed and over-general datives with 301 different verbs (44 for children). A significant effect of pre-emption—whereby the use of a verb in the prepositional-object (PO)-dative construction constitutes evidence that double-object (DO)-dative uses are not permitted—was observed for every age group. A significant effect of entrenchment—whereby the use of a verb in any construction constitutes evidence that unattested dative uses are not permitted—was also observed for every age group, with both predictors also accounting for developmental change between ages 5–6 and 9–10 years. Adults demonstrated knowledge of a morphophonological constraint that prohibits Latinate verbs from appearing in the DO-dative construction (e.g., *I suggested her the trip). Verbs’ semantic properties (supplied by independent adult raters) explained additional variance for all groups and developmentally, with the relative influence of narrow- vs broad-range semantic properties increasing with age. We conclude by outlining an account of the formation and restriction of argument-structure generalisations designed to accommodate these findings.
  • Ameka, F. K. (1989). [Review of The case for lexicase: An outline of lexicase grammatical theory by Stanley Starosta]. Studies in Language, 13(2), 506-518.
  • Ameka, F. K., & Breedveld, A. (2004). Areal cultural scripts for social interaction in West African communities. Intercultural Pragmatics, 1(2), 167-187. doi:10.1515/iprg.2004.1.2.167.

    Abstract

    Ways of interacting and not interacting in human societies have social, cognitive and cultural dimensions. These various aspects may be reflected in particular in relation to “taboos”. They reflect the ways of thinking and the values of a society. They are recognized as part of the communicative competence of the speakers and are learned in socialization. Some salient taboos are likely to be named in the language of the relevant society, others may not have a name. Interactional taboos can be specific to a cultural linguistic group or they may be shared across different communities that belong to a ‘speech area’ (Hymes 1972). In this article we describe a number of unnamed norms of communicative conduct which are widespread in West Africa such as the taboos on the use of the left hand in social interaction and on the use of personal names in adult address, and the widespread preference for the use of intermediaries for serious communication. We also examine a named avoidance (yaage) behavior specific to the Fulbe, a nomadic cattle-herding group spread from West Africa across the Sahel as far as Sudan. We show how tacit knowledge about these taboos and other interactive norms can be captured using the cultural scripts methodology.
  • Ameka, F. K. (2004). Grammar and cultural practices: The grammaticalization of triadic communication in West African languages. The Journal of West African Languages, 30(2), 5-28.
  • Araújo, S., Faísca, L., Bramão, I., Petersson, K. M., & Reis, A. (2014). Lexical and phonological processes in dyslexic readers: Evidences from a visual lexical decision task. Dyslexia, 20, 38-53. doi:10.1002/dys.1461.

    Abstract

    The aim of the present study was to investigate whether reading failure in the context of an orthography of intermediate consistency is linked to inefficient use of the lexical orthographic reading procedure. The performance of typically developing and dyslexic Portuguese-speaking children was examined in a lexical decision task, where the stimulus lexicality, word frequency and length were manipulated. Both lexicality and length effects were larger in the dyslexic group than in controls, although the interaction between group and frequency disappeared when the data were transformed to control for general performance factors. Children with dyslexia were influenced in lexical decision making by the stimulus length of words and pseudowords, whereas age-matched controls were influenced by the length of pseudowords only. These findings suggest that non-impaired readers rely mainly on lexical orthographic information, but children with dyslexia preferentially use the phonological decoding procedure—albeit poorly—most likely because they struggle to process orthographic inputs as a whole such as controls do. Accordingly, dyslexic children showed significantly poorer performance than controls for all types of stimuli, including words that could be considered over-learned, such as high-frequency words. This suggests that their orthographic lexical entries are less established in the orthographic lexicon
  • Bakker, I., Takashima, A., van Hell, J. G., Janzen, G., & McQueen, J. M. (2014). Competition from unseen or unheard novel words: Lexical consolidation across modalities. Journal of Memory and Language, 73, 116-139. doi:10.1016/j.jml.2014.03.002.

    Abstract

    In four experiments we investigated the formation of novel word memories across modalities, using competition between novel words and their existing phonological/orthographic neighbours as a test of lexical integration. Auditorily acquired novel words entered into competition both in the spoken modality (Experiment 1) and in the written modality (Experiment 4) after a consolidation period of 24 h. Words acquired from print, on the other hand, showed competition effects after 24 h in a visual word recognition task (Experiment 3) but required additional training and a consolidation period of a week before entering into spoken-word competition (Experiment 2). These cross-modal effects support the hypothesis that lexicalised rather than episodic representations underlie post-consolidation competition effects. We suggest that sublexical phoneme–grapheme conversion during novel word encoding and/or offline consolidation enables the formation of modality-specific lexemes in the untrained modality, which subsequently undergo the same cortical integration process as explicitly perceived word forms in the trained modality. Although conversion takes place in both directions, speech input showed an advantage over print both in terms of lexicalisation and explicit memory performance. In conclusion, the brain is able to integrate and consolidate internally generated lexical information as well as external perceptual input.
  • Barendse, M. T., Albers, C. J., Oort, F. J., & Timmerman, M. E. (2014). Measurement bias detection through Bayesian factor analysis. Frontiers in Psychology, 5: 1087. doi:10.3389/fpsyg.2014.01087.

    Abstract

    Measurement bias has been defined as a violation of measurement invariance. Potential violators—variables that possibly violate measurement invariance—can be investigated through restricted factor analysis (RFA). The purpose of the present paper is to investigate a Bayesian approach to estimate RFA models with interaction effects, in order to detect uniform and nonuniform measurement bias. Because modeling nonuniform bias requires an interaction term, it is more complicated than modeling uniform bias. The Bayesian approach seems especially suited for such complex models. In a simulation study we vary the type of bias (uniform, nonuniform), the type of violator (observed continuous, observed dichotomous, latent continuous), and the correlation between the trait and the violator (0.0, 0.5). For each condition, 100 sets of data are generated and analyzed. We examine the accuracy of the parameter estimates and the performance of two bias detection procedures, based on the DIC fit statistic, in Bayesian RFA. Results show that the accuracy of the estimated parameters is satisfactory. Bias detection rates are high in all conditions with an observed violator, and still satisfactory in all other conditions.
  • Baron-Cohen, S., Murphy, L., Chakrabarti, B., Craig, I., Mallya, U., Lakatosova, S., Rehnstrom, K., Peltonen, L., Wheelwright, S., Allison, C., Fisher, S. E., & Warrier, V. (2014). A genome wide association study of mathematical ability reveals an association at chromosome 3q29, a locus associated with autism and learning difficulties: A preliminary study. PLoS One, 9(5): e96374. doi:10.1371/journal.pone.0096374.

    Abstract

    Mathematical ability is heritable, but few studies have directly investigated its molecular genetic basis. Here we aimed to identify specific genetic contributions to variation in mathematical ability. We carried out a genome wide association scan using pooled DNA in two groups of U.K. samples, based on end of secondary/high school national academic exam achievement: high (n = 419) versus low (n = 183) mathematical ability while controlling for their verbal ability. Significant differences in allele frequencies between these groups were searched for in 906,600 SNPs using the Affymetrix GeneChip Human Mapping version 6.0 array. After meeting a threshold of p<1.5×10−5, 12 SNPs from the pooled association analysis were individually genotyped in 542 of the participants and analyzed to validate the initial associations (lowest p-value 1.14 ×10−6). In this analysis, one of the SNPs (rs789859) showed significant association after Bonferroni correction, and four (rs10873824, rs4144887, rs12130910 rs2809115) were nominally significant (lowest p-value 3.278 × 10−4). Three of the SNPs of interest are located within, or near to, known genes (FAM43A, SFT2D1, C14orf64). The SNP that showed the strongest association, rs789859, is located in a region on chromosome 3q29 that has been previously linked to learning difficulties and autism. rs789859 lies 1.3 kbp downstream of LSG1, and 700 bp upstream of FAM43A, mapping within the potential promoter/regulatory region of the latter. To our knowledge, this is only the second study to investigate the association of genetic variants with mathematical ability, and it highlights a number of interesting markers for future study.
  • Basnakova, J., Weber, K., Petersson, K. M., Van Berkum, J. J. A., & Hagoort, P. (2014). Beyond the language given: The neural correlates of inferring speaker meaning. Cerebral Cortex, 24(10), 2572-2578. doi:10.1093/cercor/bht112.

    Abstract

    Even though language allows us to say exactly what we mean, we often use language to say things indirectly, in a way that depends on the specific communicative context. For example, we can use an apparently straightforward sentence like "It is hard to give a good presentation" to convey deeper meanings, like "Your talk was a mess!" One of the big puzzles in language science is how listeners work out what speakers really mean, which is a skill absolutely central to communication. However, most neuroimaging studies of language comprehension have focused on the arguably much simpler, context-independent process of understanding direct utterances. To examine the neural systems involved in getting at contextually constrained indirect meaning, we used functional magnetic resonance imaging as people listened to indirect replies in spoken dialog. Relative to direct control utterances, indirect replies engaged dorsomedial prefrontal cortex, right temporo-parietal junction and insula, as well as bilateral inferior frontal gyrus and right medial temporal gyrus. This suggests that listeners take the speaker's perspective on both cognitive (theory of mind) and affective (empathy-like) levels. In line with classic pragmatic theories, our results also indicate that currently popular "simulationist" accounts of language comprehension fail to explain how listeners understand the speaker's intended message.
  • Bastiaansen, M. C. M., Böcker, K. B. E., Brunia, C. H. M., De Munck, J. C., & Spekreijse, H. (2001). Desynchronization during anticipatory attention for an upcoming stimulus: A comparative EEG/MEG study. Clinical Neurophysiology, 112, 393-403.

    Abstract

    Objectives: Our neurophysiological model of anticipatory behaviour (e.g. Acta Psychol 101 (1999) 213; Bastiaansen et al., 1999a) predicts an activation of (primary) sensory cortex during anticipatory attention for an upcoming stimulus. In this paper we attempt to demonstrate this by means of event-related desynchronization (ERD). Methods: Five subjects performed a time estimation task, and were informed about the quality of their time estimation by either visual or auditory stimuli providing Knowledge of Results (KR). EEG and MEG were recorded in separate sessions, and ERD was computed in the 8± 10 and 10±12 Hz frequency bands for both datasets. Results: Both in the EEG and the MEG we found an occipitally maximal ERD preceding the visual KR for all subjects. Preceding the auditory KR, no ERD was present in the EEG, whereas in the MEG we found an ERD over the temporal cortex in two of the 5 subjects. These subjects were also found to have higher levels of absolute power over temporal recording sites in the MEG than the other subjects, which we consider to be an indication of the presence of a `tau' rhythm (e.g. Neurosci Lett 222 (1997) 111). Conclusions: It is concluded that the results are in line with the predictions of our neurophysiological model.
  • Bastiaansen, M. C. M., & Brunia, C. H. M. (2001). Anticipatory attention: An event-related desynchronization approach. International Journal of Psychophysiology, 43, 91-107.

    Abstract

    This paper addresses the question of whether anticipatory attention - i.e. attention directed towards an upcoming stimulus in order to facilitate its processing - is realized at the neurophysiological level by a pre-stimulus desynchronization of the sensory cortex corresponding to the modality of the anticipated stimulus, reflecting then opening of a thalamocortical gate in the relevant sensory modality. It is argued that a technique called Event-Related Desynchronization (ERD) of rhythmic 10-Hz activity is well suited to study the thalamocortical processes that are thought to mediate anticipatory attention. In a series of experiments, ERD was computed on EEG and MEG data, recorded while subjects performed a time estimation task and were informed about the quality of their time estimation by stimuli providing Knowledge of Results (KR). The modality of the KR stimuli (auditory, visual, or somatosensory) was manipulated both within and between experiments. The results indicate to varying degrees that preceding the presentation of the KR stimuli, ERD is present over the sensory cortex, which corresponds to the modality of the KR stimulus. The general pattern of results supports the notion that a thalamocortical gating mechanism forms the neurophysiological basis of anticipatory attention. Furthermore, the results support the notion that Event-Related Potential(ERP) and ERD measures reflect fundamentally different neurophysiological processes.
  • Bauer, B. L. M. (2004). Vigesimal numerals in Romance: An Indo-European perspective. General Linguistics, 41, 21-46.
  • Bauer, B. L. M. (2004). [Review of the book Pre-Indo-European by Winfred P. Lehmann]. Journal of Indo-European Studies, 32, 146-155.
  • Baumann, H., Dirksmeyer, R., & Wittenburg, P. (2004). Long-term archiving. Language Archive Newsletter, 1(2), 3-3.
  • Bavin, E. L., Kidd, E., Prendergast, L., Baker, E., Dissanayake, C., & Prior, M. (2014). Severity of autism is related to children's language processing. Autism Research, 7(6), 687-694. doi:10.1002/aur.1410.

    Abstract

    Problems in language processing have been associated with autism spectrum disorder (ASD), with some research attributing the problems to overall language skills rather than a diagnosis of ASD. Lexical access was assessed in a looking-while-listening task in three groups of 5- to 7-year-old children; two had high-functioning ASD (HFA), an ASD severe (ASD-S) group (n = 16) and an ASD moderate (ASD-M) group (n = 21). The third group were typically developing (TD) (n = 48). Participants heard sentences of the form “Where's the x?” and their eye movements to targets (e.g., train), phonological competitors (e.g., tree), and distractors were recorded. Proportions of looking time at target were analyzed within 200 ms intervals. Significant group differences were found between the ASD-S and TD groups only, at time intervals 1000–1200 and 1200–1400 ms postonset. The TD group was more likely to be fixated on target. These differences were maintained after adjusting for language, verbal and nonverbal IQ, and attention scores. An analysis using parent report of autistic-like behaviors showed higher scores to be associated with lower proportions of looking time at target, regardless of group. Further analysis showed fixation for the TD group to be significantly faster than for the ASD-S. In addition, incremental processing was found for all groups. The study findings suggest that severity of autistic behaviors will impact significantly on children's language processing in real life situations when exposed to syntactically complex material. They also show the value of using online methods for understanding how young children with ASD process language. Autism Res 2014, 7: 687–694.
  • Benazzo, S., Dimroth, C., Perdue, C., & Watorek, M. (2004). Le rôle des particules additives dans la construction de la cohésion discursive en langue maternelle et en langue étrangère. Langages, 155, 76-106.

    Abstract

    We compare the use of additive particles such as aussi ('also'), encore ('again, still'), and their 'translation équivalents', in a narrative task based on a séries of piclures performed by groups of children aged 4 years, 7 years and 10 years using their first language (L1 French, German, Polish), and by adult Polish and German learners of French as a second language (L2). From the cross-sectional analysis we propose developmental patterns which show remarkable similarities for ail types of learner, but which stem from différent determining factors. For the children, the patterns can best be explained by the development of their capacity to use available items in appropriate discourse contexts; for the adults, the limitations of their linguistic répertoire at différent levels of achievement détermines the possibility of incorporating thèse items into their utterance structure. Fïnally, we discuss to what extent thèse gênerai tendencies are influenced by the specificities of the différent languages used.
  • Benyamin, B., St Pourcain, B., Davis, O. S., Davies, G., Hansell, N. K., Brion, M.-J., Kirkpatrick, R. M., Cents, R. A. M., Franić, S., Miller, M. B., Haworth, C. M. A., Meaburn, E., Price, T. S., Evans, D. M., Timpson, N., Kemp, J., Ring, S., McArdle, W., Medland, S. E., Yang, J. and 23 moreBenyamin, B., St Pourcain, B., Davis, O. S., Davies, G., Hansell, N. K., Brion, M.-J., Kirkpatrick, R. M., Cents, R. A. M., Franić, S., Miller, M. B., Haworth, C. M. A., Meaburn, E., Price, T. S., Evans, D. M., Timpson, N., Kemp, J., Ring, S., McArdle, W., Medland, S. E., Yang, J., Harris, S. E., Liewald, D. C., Scheet, P., Xiao, X., Hudziak, J. J., de Geus, E. J. C., Jaddoe, V. W. V., Starr, J. M., Verhulst, F. C., Pennell, C., Tiemeier, H., Iacono, W. G., Palmer, L. J., Montgomery, G. W., Martin, N. G., Boomsma, D. I., Posthuma, D., McGue, M., Wright, M. J., Davey Smith, G., Deary, I. J., Plomin, R., & Visscher, P. M. (2014). Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Molecular Psychiatry, 19(2), 253-258. doi:10.1038/mp.2012.184.

    Abstract

    Intelligence in childhood, as measured by psychometric cognitive tests, is a strong predictor of many important life outcomes, including educational attainment, income, health and lifespan. Results from twin, family and adoption studies are consistent with general intelligence being highly heritable and genetically stable throughout the life course. No robustly associated genetic loci or variants for childhood intelligence have been reported. Here, we report the first genome-wide association study (GWAS) on childhood intelligence (age range 6–18 years) from 17 989 individuals in six discovery and three replication samples. Although no individual single-nucleotide polymorphisms (SNPs) were detected with genome-wide significance, we show that the aggregate effects of common SNPs explain 22–46% of phenotypic variation in childhood intelligence in the three largest cohorts (P=3.9 × 10−15, 0.014 and 0.028). FNBP1L, previously reported to be the most significantly associated gene for adult intelligence, was also significantly associated with childhood intelligence (P=0.003). Polygenic prediction analyses resulted in a significant correlation between predictor and outcome in all replication cohorts. The proportion of childhood intelligence explained by the predictor reached 1.2% (P=6 × 10−5), 3.5% (P=10−3) and 0.5% (P=6 × 10−5) in three independent validation cohorts. Given the sample sizes, these genetic prediction results are consistent with expectations if the genetic architecture of childhood intelligence is like that of body mass index or height. Our study provides molecular support for the heritability and polygenic nature of childhood intelligence. Larger sample sizes will be required to detect individual variants with genome-wide significance.
  • Bercelli, F., Viaro, M., & Rossano, F. (2004). Attività in alcuni generi di psicoterapia. Rivista di psicolinguistica applicata, IV (2/3), 111-127. doi:10.1400/19208.

    Abstract

    The main aim of our paper is to contribute to the outline of a general inventory of activities in psychotherapy, as a step towards a description of overall conversational organizations of diff erent therapeutic approaches. From the perspective of Conversation Analysis, we describe some activities commonly occurrring in a corpus of sessions conducted by cognitive and relational-systemic therapists. Two activities appear to be basic: (a) inquiry: therapists elicit information from patients on their problems and circumstances; (b) reworking: therapists say something designed as an elaboration of what patients have previously said, or as something that can be grounded on it; and patients are induced to confi rm/disprove and contribute to the elaboration. Furthermore, we describe other activities, which turn out to be auxiliary to the basic ones: storytelling, procedural arrangement, recalling, noticing, teaching. We fi nally show some ways in which these activities can be integrated through conversational interaction.
  • Besharati, S., Forkel, S. J., Kopelman, M., Solms, M., Jenkinson, P. M., & Fotopoulou, A. (2014). The affective modulation of motor awareness in anosognosia for hemiplegia: Behavioural and lesion evidence. Cortex, 61, 127-140. doi:10.1016/j.cortex.2014.08.016.

    Abstract

    The possible role of emotion in anosognosia for hemiplegia (i.e., denial of motor deficits contralateral to a brain lesion), has long been debated between psychodynamic and neurocognitive theories. However, there are only a handful of case studies focussing on this topic, and the precise role of emotion in anosognosia for hemiplegia requires empirical investigation. In the present study, we aimed to investigate how negative and positive emotions influence motor awareness in anosognosia. Positive and negative emotions were induced under carefully-controlled experimental conditions in right-hemisphere stroke patients with anosognosia for hemiplegia (n = 11) and controls with clinically normal awareness (n = 10). Only the negative, emotion induction condition resulted in a significant improvement of motor awareness in anosognosic patients compared to controls; the positive emotion induction did not. Using lesion overlay and voxel-based lesion-symptom mapping approaches, we also investigated the brain lesions associated with the diagnosis of anosognosia, as well as with performance on the experimental task. Anatomical areas that are commonly damaged in AHP included the right-hemisphere motor and sensory cortices, the inferior frontal cortex, and the insula. Additionally, the insula, putamen and anterior periventricular white matter were associated with less awareness change following the negative emotion induction. This study suggests that motor unawareness and the observed lack of negative emotions about one's disabilities cannot be adequately explained by either purely motivational or neurocognitive accounts. Instead, we propose an integrative account in which insular and striatal lesions result in weak interoceptive and motivational signals. These deficits lead to faulty inferences about the self, involving a difficulty to personalise new sensorimotor information, and an abnormal adherence to premorbid beliefs about the body.

    Additional information

    supplementary file
  • Bidgood, A., Ambridge, B., Pine, J. M., & Rowland, C. F. (2014). The retreat from locative overgeneralisation errors: A novel verb grammaticality judgment study. PLoS One, 9(5): e97634. doi:10.1371/journal.pone.0097634.

    Abstract

    Whilst some locative verbs alternate between the ground- and figure-locative constructions (e.g. Lisa sprayed the flowers with water/Lisa sprayed water onto the flowers), others are restricted to one construction or the other (e.g. *Lisa filled water into the cup/*Lisa poured the cup with water). The present study investigated two proposals for how learners (aged 5–6, 9–10 and adults) acquire this restriction, using a novel-verb-learning grammaticality-judgment paradigm. In support of the semantic verb class hypothesis, participants in all age groups used the semantic properties of novel verbs to determine the locative constructions (ground/figure/both) in which they could and could not appear. In support of the frequency hypothesis, participants' tolerance of overgeneralisation errors decreased with each increasing level of verb frequency (novel/low/high). These results underline the need to develop an integrated account of the roles of semantics and frequency in the retreat from argument structure overgeneralisation.
  • Bock, K., Eberhard, K. M., Cutting, J. C., Meyer, A. S., & Schriefers, H. (2001). Some attractions of verb agreement. Cognitive Psychology, 43(2), 83-128. doi:10.1006/cogp.2001.0753.

    Abstract

    In English, words like scissors are grammatically plural but conceptually singular, while words like suds are both grammatically and conceptually plural. Words like army can be construed plurally, despite being grammatically singular. To explore whether and how congruence between grammatical and conceptual number affected the production of subject-verb number agreement in English, we elicited sentence completions for complex subject noun phrases like The advertisement for the scissors. In these phrases, singular subject nouns were followed by distractor words whose grammatical and conceptual numbers varied. The incidence of plural attraction (the use of plural verbs after plural distractors) increased only when distractors were grammatically plural, and revealed no influence from the distractors' number meanings. Companion experiments in Dutch offered converging support for this account and suggested that similar agreement processes operate in that language. The findings argue for a component of agreement that is sensitive primarily to the grammatical reflections of number. Together with other results, the evidence indicates that the implementation of agreement in languages like English and Dutch involves separable processes of number marking and number morphing, in which number meaning plays different parts.

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  • Böckler, A., Hömke, P., & Sebanz, N. (2014). Invisible Man: Exclusion from shared attention affects gaze behavior and self-reports. Social Psychological and Personality Science, 5(2), 140-148. doi:10.1177/1948550613488951.

    Abstract

    Social exclusion results in lowered satisfaction of basic needs and shapes behavior in subsequent social situations. We investigated
    participants’ immediate behavioral response during exclusion from an interaction that consisted of establishing eye contact. A
    newly developed eye-tracker-based ‘‘looking game’’ was employed; participants exchanged looks with two virtual partners in an
    exchange where the player who had just been looked at chose whom to look at next. While some participants received as many
    looks as the virtual players (included), others were ignored after two initial looks (excluded). Excluded participants reported lower
    basic need satisfaction, lower evaluation of the interaction, and devaluated their interaction partners more than included
    participants, demonstrating that people are sensitive to epistemic ostracism. In line with William’s need-threat model,
    eye-tracking results revealed that excluded participants did not withdraw from the unfavorable interaction, but increased the
    number of looks to the player who could potentially reintegrate them.
  • De Boer, B., & Perlman, M. (2014). Physical mechanisms may be as important as brain mechanisms in evolution of speech [Commentary on Ackerman, Hage, & Ziegler. Brain Mechanisms of acoustic communication in humans and nonhuman primates: an evolutionary perspective]. Behavioral and Brain Sciences, 37(6), 552-553. doi:10.1017/S0140525X13004007.

    Abstract

    We present two arguments why physical adaptations for vocalization may be as important as neural adaptations. First, fine control over vocalization is not easy for physical reasons, and modern humans may be exceptional. Second, we present an example of a gorilla that shows rudimentary voluntary control over vocalization, indicating that some neural control is already shared with great apes.
  • Bolton, J. L., Hayward, C., Direk, N., Lewis, J. G., Hammond, G. L., Hill, L. A., Anderson, A., Huffman, J., Wilson, J. F., Campbell, H., Rudan, I., Wright, A., Hastie, N., Wild, S. H., Velders, F. P., Hofman, A., Uitterlinden, A. G., Lahti, J., Räikkönen, K., Kajantie, E. and 37 moreBolton, J. L., Hayward, C., Direk, N., Lewis, J. G., Hammond, G. L., Hill, L. A., Anderson, A., Huffman, J., Wilson, J. F., Campbell, H., Rudan, I., Wright, A., Hastie, N., Wild, S. H., Velders, F. P., Hofman, A., Uitterlinden, A. G., Lahti, J., Räikkönen, K., Kajantie, E., Widen, E., Palotie, A., Eriksson, J. G., Kaakinen, M., Järvelin, M.-R., Timpson, N. J., Davey Smith, G., Ring, S. M., Evans, D. M., St Pourcain, B., Tanaka, T., Milaneschi, Y., Bandinelli, S., Ferrucci, L., van der Harst, P., Rosmalen, J. G. M., Bakker, S. J. L., Verweij, N., Dullaart, R. P. F., Mahajan, A., Lindgren, C. M., Morris, A., Lind, L., Ingelsson, E., Anderson, L. N., Pennell, C. E., Lye, S. J., Matthews, S. G., Eriksson, J., Mellstrom, D., Ohlsson, C., Price, J. F., Strachan, M. W. J., Reynolds, R. M., Tiemeier, H., Walker, B. R., & CORtisol NETwork (CORNET) Consortium (2014). Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin. PLoS Genetics, 10(7): e1004474. doi:10.1371/journal.pgen.1004474.

    Abstract

    Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated at 30-60% but no common genetic contribution has been identified. The CORtisol NETwork (CORNET) consortium undertook genome wide association meta-analysis for plasma cortisol in 12,597 Caucasian participants, replicated in 2,795 participants. The results indicate that <1% of variance in plasma cortisol is accounted for by genetic variation in a single region of chromosome 14. This locus spans SERPINA6, encoding corticosteroid binding globulin (CBG, the major cortisol-binding protein in plasma), and SERPINA1, encoding α1-antitrypsin (which inhibits cleavage of the reactive centre loop that releases cortisol from CBG). Three partially independent signals were identified within the region, represented by common SNPs; detailed biochemical investigation in a nested sub-cohort showed all these SNPs were associated with variation in total cortisol binding activity in plasma, but some variants influenced total CBG concentrations while the top hit (rs12589136) influenced the immunoreactivity of the reactive centre loop of CBG. Exome chip and 1000 Genomes imputation analysis of this locus in the CROATIA-Korcula cohort identified missense mutations in SERPINA6 and SERPINA1 that did not account for the effects of common variants. These findings reveal a novel common genetic source of variation in binding of cortisol by CBG, and reinforce the key role of CBG in determining plasma cortisol levels. In turn this genetic variation may contribute to cortisol-associated degenerative diseases.
  • Borgwaldt, S. R., Hellwig, F. M., & De Groot, A. M. B. (2004). Word-initial entropy in five langauges: Letter to sound, and sound to letter. Written Language & Literacy, 7(2), 165-184.

    Abstract

    Alphabetic orthographies show more or less ambiguous relations between spelling and sound patterns. In transparent orthographies, like Italian, the pronunciation can be predicted from the spelling and vice versa. Opaque orthographies, like English, often display unpredictable spelling–sound correspondences. In this paper we present a computational analysis of word-initial bi-directional spelling–sound correspondences for Dutch, English, French, German, and Hungarian, stated in entropy values for various grain sizes. This allows us to position the five languages on the continuum from opaque to transparent orthographies, both in spelling-to-sound and sound-to-spelling directions. The analysis is based on metrics derived from information theory, and therefore independent of any specific theory of visual word recognition as well as of any specific theoretical approach of orthography.
  • Bosker, H. R., Quené, H., Sanders, T. J. M., & de Jong, N. H. (2014). Native 'um's elicit prediction of low-frequency referents, but non-native 'um's do not. Journal of Memory and Language, 75, 104-116. doi:10.1016/j.jml.2014.05.004.

    Abstract

    Speech comprehension involves extensive use of prediction. Linguistic prediction may be guided by the semantics or syntax, but also by the performance characteristics of the speech signal, such as disfluency. Previous studies have shown that listeners, when presented with the filler uh, exhibit a disfluency bias for discourse-new or unknown referents, drawing inferences about the source of the disfluency. The goal of the present study is to study the contrast between native and non-native disfluencies in speech comprehension. Experiment 1 presented listeners with pictures of high-frequency (e.g., a hand) and low-frequency objects (e.g., a sewing machine) and with fluent and disfluent instructions. Listeners were found to anticipate reference to low-frequency objects when encountering disfluency, thus attributing disfluency to speaker trouble in lexical retrieval. Experiment 2 showed that, when participants listened to disfluent non-native speech, no anticipation of low-frequency referents was observed. We conclude that listeners can adapt their predictive strategies to the (non-native) speaker at hand, extending our understanding of the role of speaker identity in speech comprehension.
  • Bosker, H. R., Quené, H., Sanders, T. J. M., & de Jong, N. H. (2014). The perception of fluency in native and non-native speech. Language Learning, 64, 579-614. doi:10.1111/lang.12067.

    Abstract

    Where native speakers supposedly are fluent by default, non-native speakers often have to strive hard to achieve a native-like fluency level. However, disfluencies (such as pauses, fillers, repairs, etc.) occur in both native and non-native speech and it is as yet unclear ow luency raters weigh the fluency characteristics of native and non-native speech. Two rating experiments compared the way raters assess the luency of native and non-native speech. The fluency characteristics of native and non- native speech were controlled by using phonetic anipulations in pause (Experiment 1) and speed characteristics (Experiment 2). The results show that the ratings on manipulated native and on-native speech were affected in a similar fashion. This suggests that there is no difference in the way listeners weigh the fluency haracteristics of native and non-native speakers.
  • Bowerman, M. (1976). Commentary on M.D.S. Braine, “Children's first word combinations”. Monographs of the Society for Research in Child Development, 41(1), 98-104. Retrieved from http://www.jstor.org/stable/1165959.
  • Broeder, D., & Lannom, L. (2014). Data Type Registries: A Research Data Alliance Working Group. D-Lib Magazine, 20, 1. doi:10.1045/january2014-broeder.

    Abstract

    Automated processing of large amounts of scientific data, especially across domains, requires that the data can be selected and parsed without human intervention. Precise characterization of that data, as in typing, is needed once the processing goes beyond the realm of domain specific or local research group assumptions. The Research Data Alliance (RDA) Data Type Registries Working Group (DTR-WG) was assembled to address this issue through the creation of a Data Type Registry methodology, data model, and prototype. The WG was approved by the RDA Council during March of 2013 and will complete its work in mid-2014, in between the third and fourth RDA Plenaries.
  • Broeder, D. (2004). 40,000 IMDI sessions. Language Archive Newsletter, 1(4), 12-12.
  • Broeder, D., & Offenga, F. (2004). IMDI Metadata Set 3.0. Language Archive Newsletter, 1(2), 3-3.
  • Broersma, M., & De Bot, K. (2001). De triggertheorie voor codewisseling: De oorspronkelijke en een aangepaste versie (‘The trigger theory for codeswitching: The original and an adjusted version’). Toegepaste Taalwetenschap in Artikelen, 65(1), 41-54.
  • Brouwer, S., & Bradlow, A. R. (2014). Contextual variability during speech-in-speech recognition. The Journal of the Acoustical Society of America, 136(1), EL26-EL32. doi:10.1121/1.4881322.

    Abstract

    This study examined the influence of background language variation on speech recognition. English listeners performed an English sentence recognition task in either “pure” background conditions in which all trials had either English or Dutch background babble or in mixed background conditions in which the background language varied across trials (i.e., a mix of English and Dutch or one of these background languages mixed with quiet trials). This design allowed the authors to compare performance on identical trials across pure and mixed conditions. The data reveal that speech-in-speech recognition is sensitive to contextual variation in terms of the target-background language (mis)match depending on the relative ease/difficulty of the test trials in relation to the surrounding trials.
  • Brown, P. (1989). [Review of the book Language, gender, and sex in comparative perspective ed. by Susan U. Philips, Susan Steeleand Christine Tanz]. Man, 24(1), 192.
  • Brown, P. (1976). Women and politeness: A new perspective on language and society. Reviews in Anthropology, 3, 240-249.
  • Brucato, N., DeLisi, L. E., Fisher, S. E., & Francks, C. (2014). Hypomethylation of the paternally inherited LRRTM1 promoter linked to schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 165(7), 555-563. doi:10.1002/ajmg.b.32258.

    Abstract

    Epigenetic effects on psychiatric traits remain relatively under-studied, and it remains unclear what the sizes of individual epigenetic effects may be, or how they vary between different clinical populations. The gene LRRTM1 (chromosome 2p12) has previously been linked and associated with schizophrenia in a parent-of-origin manner in a set of affected siblings (LOD = 4.72), indirectly suggesting a disruption of paternal imprinting at this locus in these families. From the same set of siblings that originally showed strong linkage at this locus, we analyzed 99 individuals using 454-bisulfite sequencing, from whole blood DNA, to measure the level of DNA methylation in the promoter region of LRRTM1. We also assessed seven additional loci that would be informative to compare. Paternal identity-by-descent sharing at LRRTM1, within sibling pairs, was linked to their similarity of methylation at the gene's promoter. Reduced methylation at the promoter showed a significant association with schizophrenia. Sibling pairs concordant for schizophrenia showed more similar methylation levels at the LRRTM1 promoter than diagnostically discordant pairs. The alleles of common SNPs spanning the locus did not explain this epigenetic linkage, which can therefore be considered as largely independent of DNA sequence variation and would not be detected in standard genetic association analysis. Our data suggest that hypomethylation at the LRRTM1 promoter, particularly of the paternally inherited allele, was a risk factor for the development of schizophrenia in this set of siblings affected with familial schizophrenia, and that had previously showed linkage at this locus in an affected-sib-pair context.
  • Brugman, H. (2004). ELAN 2.2 now available. Language Archive Newsletter, 1(3), 13-14.
  • Brugman, H., Sloetjes, H., Russel, A., & Klassmann, A. (2004). ELAN 2.3 available. Language Archive Newsletter, 1(4), 13-13.
  • Brugman, H. (2004). ELAN Releases 2.0.2 and 2.1. Language Archive Newsletter, 1(2), 4-4.
  • Burenhult, N. (2004). Landscape terms and toponyms in Jahai: A field report. Lund Working Papers, 51, 17-29.
  • Cai, D., Fonteijn, H. M., Guadalupe, T., Zwiers, M., Wittfeld, K., Teumer, A., Hoogman, M., Arias Vásquez, A., Yang, Y., Buitelaar, J., Fernández, G., Brunner, H. G., Van Bokhoven, H., Franke, B., Hegenscheid, K., Homuth, G., Fisher, S. E., Grabe, H. J., Francks, C., & Hagoort, P. (2014). A genome wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. Genes, Brain and Behavior, 13, 675-685. doi:10.1111/gbb.12157.

    Abstract

    Heschl's gyrus (HG) is a core region of the auditory cortex whose morphology is highly variable across individuals. This variability has been linked to sound perception ability in both speech and music domains. Previous studies show that variations in morphological features of HG, such as cortical surface area and thickness, are heritable. To identify genetic variants that affect HG morphology, we conducted a genome-wide association scan (GWAS) meta-analysis in 3054 healthy individuals using HG surface area and thickness as quantitative traits. None of the single nucleotide polymorphisms (SNPs) showed association P values that would survive correction for multiple testing over the genome. The most significant association was found between right HG area and SNP rs72932726 close to gene DCBLD2 (3q12.1; P=2.77x10(-7)). This SNP was also associated with other regions involved in speech processing. The SNP rs333332 within gene KALRN (3q21.2; P=2.27x10(-6)) and rs143000161 near gene COBLL1 (2q24.3; P=2.40x10(-6)) were associated with the area and thickness of left HG, respectively. Both genes are involved in the development of the nervous system. The SNP rs7062395 close to the X-linked deafness gene POU3F4 was associated with right HG thickness (Xq21.1; P=2.38x10(-6)). This is the first molecular genetic analysis of variability in HG morphology
  • Capilla, A., Schoffelen, J.-M., Paterson, G., Thut, G., & Gross, J. (2014). Dissociated α-band modulations in the dorsal and ventral visual pathways in visuospatial attention and perception. Cerebral Cortex., 24(2), 550-561. doi:10.1093/cercor/bhs343.

    Abstract

    Modulations of occipito-parietal α-band (8–14 Hz) power that are opposite in direction (α-enhancement vs. α-suppression) and origin of generation (ipsilateral vs. contralateral to the locus of attention) are a robust correlate of anticipatory visuospatial attention. Yet, the neural generators of these α-band modulations, their interdependence across homotopic areas, and their respective contribution to subsequent perception remain unclear. To shed light on these questions, we employed magnetoencephalography, while human volunteers performed a spatially cued detection task. Replicating previous findings, we found α-power enhancement ipsilateral to the attended hemifield and contralateral α-suppression over occipitoparietal sensors. Source localization (beamforming) analysis showed that α-enhancement and suppression were generated in 2 distinct brain regions, located in the dorsal and ventral visual streams, respectively. Moreover, α-enhancement and suppression showed different dynamics and contribution to perception. In contrast to the initial and transient dorsal α-enhancement, α-suppression in ventro-lateral occipital cortex was sustained and influenced subsequent target detection. This anticipatory biasing of ventrolateral extrastriate α-activity probably reflects increased receptivity in the brain region specialized in processing upcoming target features. Our results add to current models on the role of α-oscillations in attention orienting by showing that α-enhancement and suppression can be dissociated in time, space, and perceptual relevance.

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  • Carlsson, K., Petersson, K. M., Lundqvist, D., Karlsson, A., Ingvar, M., & Öhman, A. (2004). Fear and the amygdala: manipulation of awareness generates differential cerebral responses to phobic and fear-relevant (but nonfeared) stimuli. Emotion, 4(4), 340-353. doi:10.1037/1528-3542.4.4.340.

    Abstract

    Rapid response to danger holds an evolutionary advantage. In this positron emission tomography study, phobics were exposed to masked visual stimuli with timings that either allowed awareness or not of either phobic, fear-relevant (e.g., spiders to snake phobics), or neutral images. When the timing did not permit awareness, the amygdala responded to both phobic and fear-relevant stimuli. With time for more elaborate processing, phobic stimuli resulted in an addition of an affective processing network to the amygdala activity, whereas no activity was found in response to fear-relevant stimuli. Also, right prefrontal areas appeared deactivated, comparing aware phobic and fear-relevant conditions. Thus, a shift from top-down control to an affectively driven system optimized for speed was observed in phobic relative to fear-relevant aware processing.
  • Ceroni, F., Simpson, N. H., Francks, C., Baird, G., Conti-Ramsden, G., Clark, A., Bolton, P. F., Hennessy, E. R., Donnelly, P., Bentley, D. R., Martin, H., IMGSAC, SLI Consortium, WGS500 Consortium, Parr, J., Pagnamenta, A. T., Maestrini, E., Bacchelli, E., Fisher, S. E., & Newbury, D. F. (2014). Homozygous microdeletion of exon 5 in ZNF277 in a girl with specific language impairment. European Journal of Human Genetics, 22, 1165-1171. doi:10.1038/ejhg.2014.4.

    Abstract

    Specific language impairment (SLI), an unexpected failure to develop appropriate language skills despite adequate non-verbal intelligence, is a heterogeneous multifactorial disorder with a complex genetic basis. We identified a homozygous microdeletion of 21,379 bp in the ZNF277 gene (NM_021994.2), encompassing exon 5, in an individual with severe receptive and expressive language impairment. The microdeletion was not found in the proband’s affected sister or her brother who had mild language impairment. However, it was inherited from both parents, each of whom carries a heterozygous microdeletion and has a history of language problems. The microdeletion falls within the AUTS1 locus, a region linked to autistic spectrum disorders (ASDs). Moreover, ZNF277 is adjacent to the DOCK4 and IMMP2L genes, which have been implicated in ASD. We screened for the presence of ZNF277 microdeletions in cohorts of children with SLI or ASD and panels of control subjects. ZNF277 microdeletions were at an increased allelic frequency in SLI probands (1.1%) compared with both ASD family members (0.3%) and independent controls (0.4%). We performed quantitative RT-PCR analyses of the expression of IMMP2L, DOCK4 and ZNF277 in individuals carrying either an IMMP2L_DOCK4 microdeletion or a ZNF277 microdeletion. Although ZNF277 microdeletions reduce the expression of ZNF277, they do not alter the levels of DOCK4 or IMMP2L transcripts. Conversely, IMMP2L_DOCK4 microdeletions do not affect the expression levels of ZNF277. We postulate that ZNF277 microdeletions may contribute to the risk of language impairments in a manner that is independent of the autism risk loci previously described in this region.
  • Chen, A., Gussenhoven, C., & Rietveld, T. (2004). Language specificity in perception of paralinguistic intonational meaning. Language and Speech, 47(4), 311-349.

    Abstract

    This study examines the perception of paralinguistic intonational meanings deriving from Ohala’s Frequency Code (Experiment 1) and Gussenhoven’s Effort Code (Experiment 2) in British English and Dutch. Native speakers of British English and Dutch listened to a number of stimuli in their native language and judged each stimulus on four semantic scales deriving from these two codes: SELF-CONFIDENT versus NOT SELF-CONFIDENT, FRIENDLY versus NOT FRIENDLY (Frequency Code); SURPRISED versus NOT SURPRISED, and EMPHATIC versus NOT EMPHATIC (Effort Code). The stimuli, which were lexically equivalent across the two languages, differed in pitch contour, pitch register and pitch span in Experiment 1, and in pitch register, peak height, peak alignment and end pitch in Experiment 2. Contrary to the traditional view that the paralinguistic usage of intonation is similar across languages, it was found that British English and Dutch listeners differed considerably in the perception of “confident,” “friendly,” “emphatic,” and “surprised.” The present findings support a theory of paralinguistic meaning based on the universality of biological codes, which however acknowledges a languagespecific component in the implementation of these codes.
  • Cho, T. (2004). Prosodically conditioned strengthening and vowel-to-vowel coarticulation in English. Journal of Phonetics, 32(2), 141-176. doi:10.1016/S0095-4470(03)00043-3.

    Abstract

    The goal of this study is to examine how the degree of vowel-to-vowel coarticulation varies as a function of prosodic factors such as nuclear-pitch accent (accented vs. unaccented), level of prosodic boundary (Prosodic Word vs. Intermediate Phrase vs. Intonational Phrase), and position-in-prosodic-domain (initial vs. final). It is hypothesized that vowels in prosodically stronger locations (e.g., in accented syllables and at a higher prosodic boundary) are not only coarticulated less with their neighboring vowels, but they also exert a stronger influence on their neighbors. Measurements of tongue position for English /a i/ over time were obtained with Carsten’s electromagnetic articulography. Results showed that vowels in prosodically stronger locations are coarticulated less with neighboring vowels, but do not exert a stronger influence on the articulation of neighboring vowels. An examination of the relationship between coarticulation and duration revealed that (a) accent-induced coarticulatory variation cannot be attributed to a duration factor and (b) some of the data with respect to boundary effects may be accounted for by the duration factor. This suggests that to the extent that prosodically conditioned coarticulatory variation is duration-independent, there is no absolute causal relationship from duration to coarticulation. It is proposed that prosodically conditioned V-to-V coarticulatory reduction is another type of strengthening that occurs in prosodically strong locations. The prosodically driven coarticulatory patterning is taken to be part of the phonetic signatures of the hierarchically nested structure of prosody.
  • Cholin, J., Schiller, N. O., & Levelt, W. J. M. (2004). The preparation of syllables in speech production. Journal of Memory and Language, 50(1), 47-61. doi:10.1016/j.jml.2003.08.003.

    Abstract

    Models of speech production assume that syllables play a functional role in the process of word-form encoding in speech production. In this study, we investigate this claim and specifically provide evidence about the level at which syllables come into play. We report two studies using an odd-man-out variant of the implicit priming paradigm to examine the role of the syllable during the process of word formation. Our results show that this modified version of the implicit priming paradigm can trace the emergence of syllabic structure during spoken word generation. Comparing these results to prior syllable priming studies, we conclude that syllables emerge at the interface between phonological and phonetic encoding. The results are discussed in terms of the WEAVER++ model of lexical access.
  • Chu, M., Meyer, A. S., Foulkes, L., & Kita, S. (2014). Individual differences in frequency and saliency of speech-accompanying gestures: The role of cognitive abilities and empathy. Journal of Experimental Psychology: General, 143, 694-709. doi:10.1037/a0033861.

    Abstract

    The present study concerns individual differences in gesture production. We used correlational and multiple regression analyses to examine the relationship between individuals’ cognitive abilities and empathy levels and their gesture frequency and saliency. We chose predictor variables according to experimental evidence of the functions of gesture in speech production and communication. We examined 3 types of gestures: representational gestures, conduit gestures, and palm-revealing gestures. Higher frequency of representational gestures was related to poorer visual and spatial working memory, spatial transformation ability, and conceptualization ability; higher frequency of conduit gestures was related to poorer visual working memory, conceptualization ability, and higher levels of empathy; and higher frequency of palm-revealing gestures was related to higher levels of empathy. The saliency of all gestures was positively related to level of empathy. These results demonstrate that cognitive abilities and empathy levels are related to individual differences in gesture frequency and saliency
  • Chu, M., & Hagoort, P. (2014). Synchronization of speech and gesture: Evidence for interaction in action. Journal of Experimental Psychology: General, 143(4), 1726-1741. doi:10.1037/a0036281.

    Abstract

    Language and action systems are highly interlinked. A critical piece of evidence is that speech and its accompanying gestures are tightly synchronized. Five experiments were conducted to test 2 hypotheses about the synchronization of speech and gesture. According to the interactive view, there is continuous information exchange between the gesture and speech systems, during both their planning and execution phases. According to the ballistic view, information exchange occurs only during the planning phases of gesture and speech, but the 2 systems become independent once their execution has been initiated. In all experiments, participants were required to point to and/or name a light that had just lit up. Virtual reality and motion tracking technologies were used to disrupt their gesture or speech execution. Participants delayed their speech onset when their gesture was disrupted. They did so even when their gesture was disrupted at its late phase and even when they received only the kinesthetic feedback of their gesture. Also, participants prolonged their gestures when their speech was disrupted. These findings support the interactive view and add new constraints on models of speech and gesture production
  • Clahsen, H., Eisenbeiss, S., Hadler, M., & Sonnenstuhl, I. (2001). The Mental Representation of Inflected Words: An Experimental Study of Adjectives and Verbs in German. Language, 77(3), 510-534. doi:10.1353/lan.2001.0140.

    Abstract

    The authors investigate how morphological relationships between inflected word forms are represented in the mental lexicon, focusing on paradigmatic relations between regularly inflected word forms and relationships between different stem forms of the same lexeme. We present results from a series of psycholinguistic experiments investigating German adjectives (which are inflected for case, number, and gender) and the so-called strong verbs of German, which have different stem forms when inflected for person, number, tense, or mood. Evidence from three lexical-decision experiments indicates that regular affixes are stripped off from their stems for processing purposes. It will be shown that this holds for both unmarked and marked stem forms. Another set of experiments revealed priming effects between different paradigmatically related affixes and between different stem forms of the same lexeme. We will show that associative models of inflection do not capture these findings, and we explain our results in terms of combinatorial models of inflection in which regular affixes are represented in inflectional paradigms and stem variants are represented in structured lexical entries. We will also argue that the morphosyntactic features of stems and affixes form abstract underspecified entries. The experimental results indicate that the human language processor makes use of these representations.

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  • Claus, A. (2004). Access management system. Language Archive Newsletter, 1(2), 5.
  • Cooper, R. P., & Guest, O. (2014). Implementations are not specifications: Specification, replication and experimentation in computational cognitive modeling. Cognitive Systems Research, 27, 42-49. doi:10.1016/j.cogsys.2013.05.001.

    Abstract

    Contemporary methods of computational cognitive modeling have recently been criticized by Addyman and French (2012) on the grounds that they have not kept up with developments in computer technology and human–computer interaction. They present a manifesto for change according to which, it is argued, modelers should devote more effort to making their models accessible, both to non-modelers (with an appropriate easy-to-use user interface) and modelers alike. We agree that models, like data, should be freely available according to the normal standards of science, but caution against confusing implementations with specifications. Models may embody theories, but they generally also include implementation assumptions. Cognitive modeling methodology needs to be sensitive to this. We argue that specification, replication and experimentation are methodological approaches that can address this issue.
  • Cousijn, H., Eissing, M., Fernández, G., Fisher, S. E., Franke, B., Zwers, M., Harrison, P. J., & Arias-Vasquez, A. (2014). No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure. Schizophrenia Research, 159, 329-332. doi:10.1016/j.schres.2014.08.007.

    Abstract

    Single nucleotide polymorphisms (SNPs) within the MIR137, TCF4, and ZNF804A genes show genome-wide association to schizophrenia. However, the biological basis for the associations is unknown. Here, we tested the effects of these genes on brain structure in 1300 healthy adults. Using volumetry and voxel-based morphometry, neither gene-wide effects—including the combined effect of the genes—nor single SNP effects—including specific psychosis risk SNPs—were found on total brain volume, grey matter, white matter, or hippocampal volume. These results suggest that the associations between these risk genes and schizophrenia are unlikely to be mediated via effects on macroscopic brain structure.
  • Cox, S., Rösler, D., & Skiba, R. (1989). A tailor-made database for language teaching material. Literary & Linguistic Computing, 4(4), 260-264.
  • Cristia, A., Minagawa-Kawai, Y., Egorova, N., Gervain, J., Filippin, L., Cabrol, D., & Dupoux, E. (2014). Neural correlates of infant accent discrimination: An fNIRS study. Developmental Science, 17(4), 628-635. doi:10.1111/desc.12160.

    Abstract

    The present study investigated the neural correlates of infant discrimination of very similar linguistic varieties (Quebecois and Parisian French) using functional Near InfraRed Spectroscopy. In line with previous behavioral and electrophysiological data, there was no evidence that 3-month-olds discriminated the two regional accents, whereas 5-month-olds did, with the locus of discrimination in left anterior perisylvian regions. These neuroimaging results suggest that a developing language network relying crucially on left perisylvian cortices sustains infants' discrimination of similar linguistic varieties within this early period of infancy.

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  • Cristia, A., Seidl, A., Junge, C., Soderstrom, M., & Hagoort, P. (2014). Predicting individual variation in language from infant speech perception measures. Child development, 85(4), 1330-1345. doi:10.1111/cdev.12193.

    Abstract

    There are increasing reports that individual variation in behavioral and neurophysiological measures of infant speech processing predicts later language outcomes, and specifically concurrent or subsequent vocabulary size. If such findings are held up under scrutiny, they could both illuminate theoretical models of language development and contribute to the prediction of communicative disorders. A qualitative, systematic review of this emergent literature illustrated the variety of approaches that have been used and highlighted some conceptual problems regarding the measurements. A quantitative analysis of the same data established that the bivariate relation was significant, with correlations of similar strength to those found for well-established nonlinguistic predictors of language. Further exploration of infant speech perception predictors, particularly from a methodological perspective, is recommended.
  • Cristia, A., & Seidl, A. (2014). The hyperarticulation hypothesis of infant-directed speech. Journal of Child Language, 41(4), 913-934. doi:10.1017/S0305000912000669.

    Abstract

    Typically, the point vowels [i,ɑ,u] are acoustically more peripheral in infant-directed speech (IDS) compared to adult-directed speech (ADS). If caregivers seek to highlight lexically relevant contrasts in IDS, then two sounds that are contrastive should become more distinct, whereas two sounds that are surface realizations of the same underlying sound category should not. To test this prediction, vowels that are phonemically contrastive ([i-ɪ] and [eɪ-ε]), vowels that map onto the same underlying category ([æ- ] and [ε- ]), and the point vowels [i,ɑ,u] were elicited in IDS and ADS by American English mothers of two age groups of infants (four- and eleven-month-olds). As in other work, point vowels were produced in more peripheral positions in IDS compared to ADS. However, there was little evidence of hyperarticulation per se (e.g. [i-ɪ] was hypoarticulated). We suggest that across-the-board lexically based hyperarticulation is not a necessary feature of IDS.

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  • Cronin, K. A., Pieper, B., Van Leeuwen, E. J. C., Mundry, R., & Haun, D. B. M. (2014). Problem solving in the presence of others: How rank and relationship quality impact resource acquisition in chimpanzees (Pan troglodytes). PLoS One, 9(4): e93204. doi:10.1371/journal.pone.0093204.

    Abstract

    In the wild, chimpanzees (Pan troglodytes) are often faced with clumped food resources that they may know how to access but abstain from doing so due to social pressures. To better understand how social settings influence resource acquisition, we tested fifteen semi-wild chimpanzees from two social groups alone and in the presence of others. We investigated how resource acquisition was affected by relative social dominance, whether collaborative problem solving or (active or passive) sharing occurred amongst any of the dyads, and whether these outcomes were related to relationship quality as determined from six months of observational data. Results indicated that chimpanzees, regardless of rank, obtained fewer rewards when tested in the presence of others compared to when they were tested alone. Chimpanzees demonstrated behavioral inhibition; chimpanzees who showed proficient skill when alone often abstained from solving the task when in the presence of others. Finally, individuals with close social relationships spent more time together in the problem solving space, but collaboration and sharing were infrequent and sessions in which collaboration or sharing did occur contained more instances of aggression. Group living provides benefits and imposes costs, and these findings highlight that one cost of group living may be diminishing productive individual behaviors.
  • Cronin, K. A., Van Leeuwen, E. J. C., Vreeman, V., & Haun, D. B. M. (2014). Population-level variability in the social climates of four chimpanzee societies. Evolution and Human Behavior, 35(5), 389-396. doi:10.1016/j.evolhumbehav.2014.05.004.

    Abstract

    Recent debates have questioned the extent to which culturally-transmitted norms drive behavioral variation in resource sharing across human populations. We shed new light on this discussion by examining the group-level variation in the social dynamics and resource sharing of chimpanzees, a species that is highly social and forms long-term community associations but differs from humans in the extent to which cultural norms are adopted and enforced. We rely on theory developed in primate socioecology to guide our investigation in four neighboring chimpanzee groups at a sanctuary in Zambia. We used a combination of experimental and observational approaches to assess the distribution of resource holding potential in each group. In the first assessment, we measured the proportion of the population that gathered in a resource-rich zone, in the second we assessed naturally occurring social spacing via social network analysis, and in the third we assessed the degree to which benefits were equally distributed within the group. We report significant, stable group-level variation across these multiple measures, indicating that group-level variation in resource sharing and social tolerance is not necessarily reliant upon human-like cultural norms.
  • Cutler, A., Weber, A., Smits, R., & Cooper, N. (2004). Patterns of English phoneme confusions by native and non-native listeners. Journal of the Acoustical Society of America, 116(6), 3668-3678. doi:10.1121/1.1810292.

    Abstract

    Native American English and non-native(Dutch)listeners identified either the consonant or the vowel in all possible American English CV and VC syllables. The syllables were embedded in multispeaker babble at three signal-to-noise ratios(0, 8, and 16 dB). The phoneme identification
    performance of the non-native listeners was less accurate than that of the native listeners. All listeners were adversely affected by noise. With these isolated syllables, initial segments were harder to identify than final segments. Crucially, the effects of language background and noise did not interact; the performance asymmetry between the native and non-native groups was not significantly different across signal-to-noise ratios. It is concluded that the frequently reported disproportionate difficulty of non-native listening under disadvantageous conditions is not due to a disproportionate increase in phoneme misidentifications.
  • Cutler, A. (2004). On spoken-word recognition in a second language. Newsletter, American Association of Teachers of Slavic and East European Languages, 47, 15-15.
  • Cutler, A. (2014). In thrall to the vocabulary. Acoustics Australia, 42, 84-89.

    Abstract

    Vocabularies contain hundreds of thousands of words built from only a handful of phonemes; longer words inevitably tend to contain shorter ones. Recognising speech thus requires distinguishing intended words from accidentally present ones. Acoustic information in speech is used wherever it contributes significantly to this process; but as this review shows, its contribution differs across languages, with the consequences of this including: identical and equivalently present information distinguishing the same phonemes being used in Polish but not in German, or in English but not in Italian; identical stress cues being used in Dutch but not in English; expectations about likely embedding patterns differing across English, French, Japanese.
  • Cutler, A., Howard, D., & Patterson, K. E. (1989). Misplaced stress on prosody: A reply to Black and Byng. Cognitive Neuropsychology, 6, 67-83.

    Abstract

    The recent claim by Black and Byng (1986) that lexical access in reading is subject to prosodic constraints is examined and found to be unsupported. The evidence from impaired reading which Black and Byng report is based on poorly controlled stimulus materials and is inadequately analysed and reported. An alternative explanation of their findings is proposed, and new data are reported for which this alternative explanation can account but their model cannot. Finally, their proposal is shown to be theoretically unmotivated and in conflict with evidence from normal reading.
  • Cutler, A. (1976). High-stress words are easier to perceive than low-stress words, even when they are equally stressed. Texas Linguistic Forum, 2, 53-57.
  • Cutler, A. (2001). Listening to a second language through the ears of a first. Interpreting, 5, 1-23.
  • Cutler, A. (1976). Phoneme-monitoring reaction time as a function of preceding intonation contour. Perception and Psychophysics, 20, 55-60. Retrieved from http://www.psychonomic.org/search/view.cgi?id=18194.

    Abstract

    An acoustically invariant one-word segment occurred in two versions of one syntactic context. In one version, the preceding intonation contour indicated that a stress would fall at the point where this word occurred. In the other version, the preceding contour predicted reduced stress at that point. Reaction time to the initial phoneme of the word was faster in the former case, despite the fact that no acoustic correlates of stress were present. It is concluded that a part of the sentence comprehension process is the prediction of upcoming sentence accents.
  • Cutler, A. (1989). Straw modules [Commentary/Massaro: Speech perception]. Behavioral and Brain Sciences, 12, 760-762.
  • Cutler, A. (1989). The new Victorians. New Scientist, (1663), 66.
  • Cutler, A., & Van Donselaar, W. (2001). Voornaam is not a homophone: Lexical prosody and lexical access in Dutch. Language and Speech, 44, 171-195. doi:10.1177/00238309010440020301.

    Abstract

    Four experiments examined Dutch listeners’ use of suprasegmental information in spoken-word recognition. Isolated syllables excised from minimal stress pairs such as VOORnaam/voorNAAM could be reliably assigned to their source words. In lexical decision, no priming was observed from one member of minimal stress pairs to the other, suggesting that the pairs’ segmental ambiguity was removed by suprasegmental information.Words embedded in nonsense strings were harder to detect if the nonsense string itself formed the beginning of a competing word, but a suprasegmental mismatch to the competing word significantly reduced this inhibition. The same nonsense strings facilitated recognition of the longer words of which they constituted the beginning, butagain the facilitation was significantly reduced by suprasegmental mismatch. Together these results indicate that Dutch listeners effectively exploit suprasegmental cues in recognizing spoken words. Nonetheless, suprasegmental mismatch appears to be somewhat less effective in constraining activation than segmental mismatch.
  • Dahan, D., & Tanenhaus, M. K. (2004). Continuous mapping from sound to meaning in spoken-language comprehension: Immediate effects of verb-based thematic constraints. Journal of Experimental Psychology: Learning, Memory, and Cognition, 30(2), 498-513. doi:10.1037/0278-7393.30.2.498.

    Abstract

    The authors used 2 “visual-world” eye-tracking experiments to examine lexical access using Dutch constructions in which the verb did or did not place semantic constraints on its subsequent subject noun phrase. In Experiment 1, fixations to the picture of a cohort competitor (overlapping with the onset of the referent’s name, the subject) did not differ from fixations to a distractor in the constraining-verb condition. In Experiment 2, cross-splicing introduced phonetic information that temporarily biased the input toward the cohort competitor. Fixations to the cohort competitor temporarily increased in both the neutral and constraining conditions. These results favor models in which mapping from the input onto meaning is continuous over models in which contextual effects follow access of an initial form-based competitor set.
  • Damian, M. F., Vigliocco, G., & Levelt, W. J. M. (2001). Effects of semantic context in the naming of pictures and words. Cognition, 81, B77-B86. doi:10.1016/S0010-0277(01)00135-4.

    Abstract

    Two experiments investigated whether lexical retrieval for speaking can be characterized as a competitive process by assessing the effects of semantic context on picture and word naming in German. In Experiment 1 we demonstrated that pictures are named slower in the context of same-category items than in the context of items from various semantic categories, replicating findings by Kroll and Stewart (Journal of Memory and Language, 33 (1994) 149). In Experiment 2 we used words instead of pictures. Participants either named the words in the context of same- or different-category items, or produced the words together with their corresponding determiner. While in the former condition words were named faster in the context of samecategory items than of different-category items, the opposite pattern was obtained for the latter condition. These findings confirm the claim that the interfering effect of semantic context reflects competition in the retrieval of lexical entries in speaking.
  • Dautriche, I., Cristia, A., Brusini, P., Yuan, S., Fisher, C., & Christophe, A. (2014). Toddlers default to canonical surface-to-meaning mapping when learning verbs. Child Development, 85(3), 1168-1180. doi:10.1111/cdev.12183.

    Abstract

    This work was supported by grants from the French Agence Nationale de la Recherche (ANR-2010-BLAN-1901) and from French Fondation de France to Anne Christophe, from the National Institute of Child Health and Human Development (HD054448) to Cynthia Fisher, Fondation Fyssen and Ecole de Neurosciences de Paris to Alex Cristia, and a PhD fellowship from the Direction Générale de l'Armement (DGA, France) supported by the PhD program FdV (Frontières du Vivant) to Isabelle Dautriche. We thank Isabelle Brunet for the recruitment, Michel Dutat for the technical support, and Hernan Anllo for his puppet mastery skill. We are grateful to the families that participated in this study. We also thank two anonymous reviewers for their comments on an earlier draft of this manuscript.
  • Defina, R. (2014). Arbil: Free tool for creating, editing and searching metadata. Language Documentation and Conservation, 8, 307-314.
  • Deriziotis, P., O'Roak, B. J., Graham, S. A., Estruch, S. B., Dimitropoulou, D., Bernier, R. A., Gerdts, J., Shendure, J., Eichler, E. E., & Fisher, S. E. (2014). De novo TBR1 mutations in sporadic autism disrupt protein functions. Nature Communications, 5: 4954. doi:10.1038/ncomms5954.

    Abstract

    Next-generation sequencing recently revealed that recurrent disruptive mutations in a few genes may account for 1% of sporadic autism cases. Coupling these novel genetic data to empirical assays of protein function can illuminate crucial molecular networks. Here we demonstrate the power of the approach, performing the first functional analyses of TBR1 variants identified in sporadic autism. De novo truncating and missense mutations disrupt multiple aspects of TBR1 function, including subcellular localization, interactions with co-regulators and transcriptional repression. Missense mutations inherited from unaffected parents did not disturb function in our assays. We show that TBR1 homodimerizes, that it interacts with FOXP2, a transcription factor implicated in speech/language disorders, and that this interaction is disrupted by pathogenic mutations affecting either protein. These findings support the hypothesis that de novo mutations in sporadic autism have severe functional consequences. Moreover, they uncover neurogenetic mechanisms that bridge different neurodevelopmental disorders involving language deficits.
  • Deriziotis, P., Graham, S. A., Estruch, S. B., & Fisher, S. E. (2014). Investigating protein-protein interactions in live cells using Bioluminescence Resonance Energy Transfer. Journal of visualized experiments, 87: e51438. doi:10.3791/51438.

    Abstract

    Assays based on Bioluminescence Resonance Energy Transfer (BRET) provide a sensitive and reliable means to monitor protein-protein interactions in live cells. BRET is the non-radiative transfer of energy from a ‘donor’ luciferase enzyme to an ‘acceptor’ fluorescent protein. In the most common configuration of this assay, the donor is Renilla reniformis luciferase and the acceptor is Yellow Fluorescent Protein (YFP). Because the efficiency of energy transfer is strongly distance-dependent, observation of the BRET phenomenon requires that the donor and acceptor be in close proximity. To test for an interaction between two proteins of interest in cultured mammalian cells, one protein is expressed as a fusion with luciferase and the second as a fusion with YFP. An interaction between the two proteins of interest may bring the donor and acceptor sufficiently close for energy transfer to occur. Compared to other techniques for investigating protein-protein interactions, the BRET assay is sensitive, requires little hands-on time and few reagents, and is able to detect interactions which are weak, transient, or dependent on the biochemical environment found within a live cell. It is therefore an ideal approach for confirming putative interactions suggested by yeast two-hybrid or mass spectrometry proteomics studies, and in addition it is well-suited for mapping interacting regions, assessing the effect of post-translational modifications on protein-protein interactions, and evaluating the impact of mutations identified in patient DNA.

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  • Devanna, P., & Vernes, S. C. (2014). A direct molecular link between the autism candidate gene RORa and the schizophrenia candidate MIR137. Scientific Reports, 4: 3994. doi:10.1038/srep03994.

    Abstract

    Retinoic acid-related orphan receptor alpha gene (RORa) and the microRNA MIR137 have both recently been identified as novel candidate genes for neuropsychiatric disorders. RORa encodes a ligand-dependent orphan nuclear receptor that acts as a transcriptional regulator and miR-137 is a brain enriched small non-coding RNA that interacts with gene transcripts to control protein levels. Given the mounting evidence for RORa in autism spectrum disorders (ASD) and MIR137 in schizophrenia and ASD, we investigated if there was a functional biological relationship between these two genes. Herein, we demonstrate that miR-137 targets the 3'UTR of RORa in a site specific manner. We also provide further support for MIR137 as an autism candidate by showing that a large number of previously implicated autism genes are also putatively targeted by miR-137. This work supports the role of MIR137 as an ASD candidate and demonstrates a direct biological link between these previously unrelated autism candidate genes
  • Devanna, P., Middelbeek, J., & Vernes, S. C. (2014). FOXP2 drives neuronal differentiation by interacting with retinoic acid signaling pathways. Frontiers in Cellular Neuroscience, 8: 305. doi:10.3389/fncel.2014.00305.

    Abstract

    FOXP2 was the first gene shown to cause a Mendelian form of speech and language disorder. Although developmentally expressed in many organs, loss of a single copy of FOXP2 leads to a phenotype that is largely restricted to orofacial impairment during articulation and linguistic processing deficits. Why perturbed FOXP2 function affects specific aspects of the developing brain remains elusive. We investigated the role of FOXP2 in neuronal differentiation and found that FOXP2 drives molecular changes consistent with neuronal differentiation in a human model system. We identified a network of FOXP2 regulated genes related to retinoic acid signaling and neuronal differentiation. FOXP2 also produced phenotypic changes associated with neuronal differentiation including increased neurite outgrowth and reduced migration. Crucially, cells expressing FOXP2 displayed increased sensitivity to retinoic acid exposure. This suggests a mechanism by which FOXP2 may be able to increase the cellular differentiation response to environmental retinoic acid cues for specific subsets of neurons in the brain. These data demonstrate that FOXP2 promotes neuronal differentiation by interacting with the retinoic acid signaling pathway and regulates key processes required for normal circuit formation such as neuronal migration and neurite outgrowth. In this way, FOXP2, which is found only in specific subpopulations of neurons in the brain, may drive precise neuronal differentiation patterns and/or control localization and connectivity of these FOXP2 positive cells
  • Dingemanse, M., & Enfield, N. J. (2014). Ongeschreven regels van de taal. Psyche en Brein, 6, 6-11.

    Abstract

    Als je wereldwijd gesprekken beluistert, merk je dat de menselijke dialoog universele regels volgt. Die sturen en verrijken onze sociale interactie.
  • Dingemanse, M., Blythe, J., & Dirksmeyer, T. (2014). Formats for other-initiation of repair across languages: An exercise in pragmatic typology. Studies in Language, 38, 5-43. doi:10.1075/sl.38.1.01din.

    Abstract

    In conversation, people have to deal with problems of speaking, hearing, and understanding. We report on a cross-linguistic investigation of the conversational structure of other-initiated repair (also known as collaborative repair, feedback, requests for clarification, or grounding sequences). We take stock of formats for initiating repair across languages (comparable to English huh?, who?, y’mean X?, etc.) and find that different languages make available a wide but remarkably similar range of linguistic resources for this function. We exploit the patterned variation as evidence for several underlying concerns addressed by repair initiation: characterising trouble, managing responsibility, and handling knowledge. The concerns do not always point in the same direction and thus provide participants in interaction with alternative principles for selecting one format over possible others. By comparing conversational structures across languages, this paper contributes to pragmatic typology: the typology of systems of language use and the principles that shape them
  • Dingemanse, M. (2014). Making new ideophones in Siwu: Creative depiction in conversation. Pragmatics and Society, 5(3), 384-405. doi:10.1075/ps.5.3.04din.

    Abstract

    Ideophones are found in many of the world’s languages. Though they are a major word class on a par with nouns and verbs, their origins are ill-understood, and the question of ideophone creation has been a source of controversy. This paper studies ideophone creation in naturally occurring speech. New, unconventionalised ideophones are identified using native speaker judgements, and are studied in context to understand the rules and regularities underlying their production and interpretation. People produce and interpret new ideophones with the help of the semiotic infrastructure that underlies the use of existing ideophones: foregrounding frames certain stretches of speech as depictive enactments of sensory imagery, and various types of iconicity link forms and meanings. As with any creative use of linguistic resources, context and common ground also play an important role in supporting rapid ‘good enough’ interpretations of new material. The making of new ideophones is a special case of a more general phenomenon of creative depiction: the art of presenting verbal material in such a way that the interlocutor recognises and interprets it as a depiction.
  • Dingemanse, M., & Enfield, N. J. (2014). Let's talk: Universal social rules underlie languages. Scientific American Mind, 25, 64-69. doi:10.1038/scientificamericanmind0914-64.

    Abstract

    Recent developments in the science of language signal the emergence of a new paradigm for language study: a social approach to the fundamental questions of what language is like, how much languages really have in common, and why only our species has it. The key to these developments is a new appreciation of the need to study everyday spoken language, with all its complications and ‘imperfections’, in a systematic way. The work reviewed in this article —on turn-taking, timing, and other-initiated repair in languages around the world— has important implications for our understanding of human sociality and sheds new light on the social shape of language. For the first time in the history of linguistics, we are no longer tied to what can be written down or thought up. Rather, we look at language as a biologist would: as it occurs in nature.
  • Dobel, C., Pulvermüller, F., Härle, M., Cohen, R., Köbbel, P., Schönle, P. W., & Rockstroh, B. (2001). Syntactic and semantic processing in the healthy and aphasic human brain. Experimental Brain Research, 140(1), 77-85. doi:10.1007/s002210100794.

    Abstract

    A syntactic and a semantic task were per-formed by German-speaking healthy subjects and apha-sics with lesions in the dominant left hemisphere. In both
    tasks, pictures of objects were presented that had to be classified by pressing buttons. The classification was into grammatical gender in the syntactic task (masculine or feminine gender?) and into semantic category in the se-
    mantic task (man- or nature made?). Behavioral data revealed a significant Group by Task interaction, with
    aphasics showing most pronounced problems with syn-
    tax. Brain event-related potentials 300–600 ms following picture onset showed different task-dependent laterality
    patterns in the two groups. In controls, the syntax task
    induced a left-lateralized negative ERP, whereas the semantic task produced more symmetric responses over the hemispheres. The opposite was the case in the patients, where, paradoxically, stronger laterality of physio-logical brain responses emerged in the semantic task than in the syntactic task. We interpret these data based on neuro-psycholinguistic models of word processing and current theories about the roles of the hemispheres in language recovery.
  • Dolscheid, S., Hunnius, S., Casasanto, D., & Majid, A. (2014). Prelinguistic infants are sensitive to space-pitch associations found across cultures. Psychological Science, 25(6), 1256-1261. doi:10.1177/0956797614528521.

    Abstract

    People often talk about musical pitch using spatial metaphors. In English, for instance, pitches can be “high” or “low” (i.e., height-pitch association), whereas in other languages, pitches are described as “thin” or “thick” (i.e., thickness-pitch association). According to results from psychophysical studies, metaphors in language can shape people’s nonlinguistic space-pitch representations. But does language establish mappings between space and pitch in the first place, or does it only modify preexisting associations? To find out, we tested 4-month-old Dutch infants’ sensitivity to height-pitch and thickness-pitch mappings using a preferential-looking paradigm. The infants looked significantly longer at cross-modally congruent stimuli for both space-pitch mappings, which indicates that infants are sensitive to these associations before language acquisition. The early presence of space-pitch mappings means that these associations do not originate from language. Instead, language builds on preexisting mappings, changing them gradually via competitive associative learning. Space-pitch mappings that are language-specific in adults develop from mappings that may be universal in infants.
  • Dronkers, N. F., Wilkins, D. P., Van Valin Jr., R. D., Redfern, B. B., & Jaeger, J. J. (2004). Lesion analysis of the brain areas involved in language comprehension. Cognition, 92, 145-177. doi:10.1016/j.cognition.2003.11.002.

    Abstract

    The cortical regions of the brain traditionally associated with the comprehension of language are Wernicke's area and Broca's area. However, recent evidence suggests that other brain regions might also be involved in this complex process. This paper describes the opportunity to evaluate a large number of brain-injured patients to determine which lesioned brain areas might affect language comprehension. Sixty-four chronic left hemisphere stroke patients were evaluated on 11 subtests of the Curtiss–Yamada Comprehensive Language Evaluation – Receptive (CYCLE-R; Curtiss, S., & Yamada, J. (1988). Curtiss–Yamada Comprehensive Language Evaluation. Unpublished test, UCLA). Eight right hemisphere stroke patients and 15 neurologically normal older controls also participated. Patients were required to select a single line drawing from an array of three or four choices that best depicted the content of an auditorily-presented sentence. Patients' lesions obtained from structural neuroimaging were reconstructed onto templates and entered into a voxel-based lesion-symptom mapping (VLSM; Bates, E., Wilson, S., Saygin, A. P., Dick, F., Sereno, M., Knight, R. T., & Dronkers, N. F. (2003). Voxel-based lesion-symptom mapping. Nature Neuroscience, 6(5), 448–450.) analysis along with the behavioral data. VLSM is a brain–behavior mapping technique that evaluates the relationships between areas of injury and behavioral performance in all patients on a voxel-by-voxel basis, similar to the analysis of functional neuroimaging data. Results indicated that lesions to five left hemisphere brain regions affected performance on the CYCLE-R, including the posterior middle temporal gyrus and underlying white matter, the anterior superior temporal gyrus, the superior temporal sulcus and angular gyrus, mid-frontal cortex in Brodmann's area 46, and Brodmann's area 47 of the inferior frontal gyrus. Lesions to Broca's and Wernicke's areas were not found to significantly alter language comprehension on this particular measure. Further analysis suggested that the middle temporal gyrus may be more important for comprehension at the word level, while the other regions may play a greater role at the level of the sentence. These results are consistent with those seen in recent functional neuroimaging studies and offer complementary data in the effort to understand the brain areas underlying language comprehension.
  • Drude, S. (2001). Entschlüsselung einer unbekannten Indianersprache: Ein Projekt zur Dokumentation der bedrohten brasilianischen Indianersprache Awetí. Fundiert: Das Wissenschaftsmagazin der Freien Universität Berlin, 2, 112-121. Retrieved from http://www.elfenbeinturm.net/archiv/2001/lust3.html.

    Abstract

    Die Awetí sind ein kleiner Indianerstamm in Zentralbrasilien, der bislang nur wenig Kontakt mit Weißen hatte. Im Zuge eines Programms der Volkswagenstiftung zur Dokumentation bedrohter Sprachen wird unser Autor die Awetí erneut besuchen und berichtet als „jüngerer Bruder des Häuptlings“ über seine Bemühungen, die Sprache der Awetí für künftige Generationen festzuhalten.
  • Drude, S., Broeder, D., & Trilsbeek, P. (2014). The Language Archive and its solutions for sustainable endangered languages corpora. Book 2.0, 4, 5-20. doi:10.1386/btwo.4.1-2.5_1.

    Abstract

    Since the late 1990s, the technical group at the Max-Planck-Institute for Psycholinguistics has worked on solutions for important challenges in building sustainable data archives, in particular, how to guarantee long-time-availability of digital research data for future research. The support for the well-known DOBES (Documentation of Endangered Languages) programme has greatly inspired and advanced this work, and lead to the ongoing development of a whole suite of tools for annotating, cataloguing and archiving multi-media data. At the core of the LAT (Language Archiving Technology) tools is the IMDI metadata schema, now being integrated into a larger network of digital resources in the European CLARIN project. The multi-media annotator ELAN (with its web-based cousin ANNEX) is now well known not only among documentary linguists. We aim at presenting an overview of the solutions, both achieved and in development, for creating and exploiting sustainable digital data, in particular in the area of documenting languages and cultures, and their interfaces with related other developments
  • Dunn, M. (2014). [Review of the book Evolutionary Linguistics by April McMahon and Robert McMahon]. American Anthropologist, 116(3), 690-691.
  • Eaves, L. J., St Pourcain, B., Smith, G. D., York, T. P., & Evans, D. M. (2014). Resolving the Effects of Maternal and Offspring Genotype on Dyadic Outcomes in Genome Wide Complex Trait Analysis (“M-GCTA”). Behavior Genetics, 44(5), 445-455. doi:10.1007/s10519-014-9666-6.

    Abstract

    Genome wide complex trait analysis (GCTA) is extended to include environmental effects of the maternal genotype on offspring phenotype (“maternal effects”, M-GCTA). The model includes parameters for the direct effects of the offspring genotype, maternal effects and the covariance between direct and maternal effects. Analysis of simulated data, conducted in OpenMx, confirmed that model parameters could be recovered by full information maximum likelihood (FIML) and evaluated the biases that arise in conventional GCTA when indirect genetic effects are ignored. Estimates derived from FIML in OpenMx showed very close agreement to those obtained by restricted maximum likelihood using the published algorithm for GCTA. The method was also applied to illustrative perinatal phenotypes from ~4,000 mother-offspring pairs from the Avon Longitudinal Study of Parents and Children. The relative merits of extended GCTA in contrast to quantitative genetic approaches based on analyzing the phenotypic covariance structure of kinships are considered.
  • Enfield, N. J. (2004). On linear segmentation and combinatorics in co-speech gesture: A symmetry-dominance construction in Lao fish trap descriptions. Semiotica, 149(1/4), 57-123. doi:10.1515/semi.2004.038.
  • Enfield, N. J. (2001). ‘Lip-pointing’: A discussion of form and function with reference to data from Laos. Gesture, 1(2), 185-211. doi:10.1075/gest.1.2.06enf.

    Abstract

    ‘Lip-pointing’ is a widespread but little-documented form of deictic gesture, which may involve not just protruding one or both lips, but also raising the head, sticking out the chin, lifting the eyebrows, among other things. This paper discusses form and function of lip-pointing with reference to a set of examples collected on video in Laos. There are various parameters with respect to which the conventional form of a lip-pointing gesture may vary. There is also a range of ways in which lip-pointing gestures can be coordinated with other kinds of deictic gesture such as various forms of hand pointing. The attested coordinating/sequencing possibilities can be related to specific functional properties of lip-pointing among Lao speakers, particularly in the context of other forms of deictic gesture, which have different functional properties. It is argued that the ‘vector’ of lip-pointing is in fact defined by gaze, and that the lip-pointing action itself (like other kinds of ‘pointing’ involving the head area) is a ‘gaze-switch’, i.e. it indicates that the speaker is now pointing out something with his or her gaze. Finally, I consider the position of lip-pointing in the broader deictic gesture system of Lao speakers, firstly as a ‘lower register’ form, and secondly as a form of deictic gesture which may contrast with forms of hand pointing.
  • Enfield, N. J. (2004). Nominal classification in Lao: A sketch. Sprachtypologie und Universalienforschung, 57(2/3), 117-143.
  • Enfield, N. J. (2001). Remarks on John Haiman, 1999. ‘Auxiliation in Khmer: the case of baan.’ Studies in Language 23:1. Studies in Language, 25(1), 115-124. doi:10.1075/sl.25.1.05enf.

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