Publications

Displaying 201 - 300 of 602
  • Hagoort, P. (2002). De koninklijke verloving tussen psychologie en neurowetenschap. De Psycholoog, 37, 107-113.
  • Hagoort, P. (2004). Er is geen behoefte aan trompetten als gordijnen. In H. Procee, H. Meijer, P. Timmerman, & R. Tuinsma (Eds.), Bij die wereld wil ik horen! Zesendertig columns en drie essays over de vorming tot academicus (pp. 78-80). Amsterdam: Boom.
  • Hagoort, P., Hald, L. A., Bastiaansen, M. C. M., & Petersson, K. M. (2004). Integration of word meaning and world knowledge in language comprehension. Science, 304(5669), 438-441. doi:10.1126/science.1095455.

    Abstract

    Although the sentences that we hear or read have meaning, this does not necessarily mean that they are also true. Relatively little is known about the critical brain structures for, and the relative time course of, establishing the meaning and truth of linguistic expressions. We present electroencephalogram data that show the rapid parallel integration of both semantic and world
    knowledge during the interpretation of a sentence. Data from functional magnetic resonance imaging revealed that the left inferior prefrontal cortex is involved in the integration of both meaning and world knowledge. Finally, oscillatory brain responses indicate that the brain keeps a record of what makes a sentence hard to interpret.
  • Hagoort, P. (2004). Het zwarte gat tussen brein en bewustzijn. In N. Korteweg (Ed.), De oorsprong: Over het ontstaan van het leven en alles eromheen (pp. 107-124). Amsterdam: Boom.
  • Hagoort, P., & Brown, C. M. (1999). Gender electrified: ERP evidence on the syntactic nature of gender processing. Journal of Psycholinguistic Research, 28(6), 715-728. doi:10.1023/A:1023277213129.

    Abstract

    The central issue of this study concerns the claim that the processing of gender agreement in online sentence comprehension is a syntactic rather than a conceptual/semantic process. This claim was tested for the grammatical gender agreement in Dutch between the definite article and the noun. Subjects read sentences in which the definite article and the noun had the same gender and sentences in which the gender agreement was violated, While subjects read these sentences, their electrophysiological activity was recorded via electrodes placed on the scalp. Earlier research has shown that semantic and syntactic processing events manifest themselves in different event-related brain potential (ERP) effects. Semantic integration modulates the amplitude of the so-called N400.The P600/SPS is an ERP effect that is more sensitive to syntactic processes. The violation of grammatical gender agreement was found to result in a P600/SPS. For violations in sentence-final position, an additional increase of the N400 amplitude was observed. This N400 effect is interpreted as resulting from the consequence of a syntactic violation for the sentence-final wrap-up. The overall pattern of results supports the claim that the on-line processing of gender agreement information is not a content driven but a syntactic-form driven process.
  • Hagoort, P. (1998). Hersenen en taal in onderzoek en praktijk. Neuropraxis, 6, 204-205.
  • Hagoort, P., & Brown, C. M. (1999). The consequences of the temporal interaction between syntactic and semantic processes for haemodynamic studies of language. NeuroImage, 9, S1024-S1024.
  • Hagoort, P., Brown, C. M., & Osterhout, L. (1999). The neurocognition of syntactic processing. In C. M. Brown, & P. Hagoort (Eds.), The neurocognition of language (pp. 273-317). Oxford: Oxford University Press.
  • Hagoort, P., Ramsey, N., Rutten, G.-J., & Van Rijen, P. (1999). The role of the left anterior temporal cortex in language processing. Brain and Language, 69, 322-325. doi:10.1006/brln.1999.2169.
  • Hagoort, P. (1998). The shadows of lexical meaning in patients with semantic impairments. In B. Stemmer, & H. Whitaker (Eds.), Handbook of neurolinguistics (pp. 235-248). New York: Academic Press.
  • Hagoort, P., Indefrey, P., Brown, C. M., Herzog, H., Steinmetz, H., & Seitz, R. J. (1999). The neural circuitry involved in the reading of german words and pseudowords: A PET study. Journal of Cognitive Neuroscience, 11(4), 383-398. doi:10.1162/089892999563490.

    Abstract

    Silent reading and reading aloud of German words and pseudowords were used in a PET study using (15O)butanol to examine the neural correlates of reading and of the phonological conversion of legal letter strings, with or without meaning.
    The results of 11 healthy, right-handed volunteers in the age range of 25 to 30 years showed activation of the lingual gyri during silent reading in comparison with viewing a fixation cross. Comparisons between the reading of words and pseudowords suggest the involvement of the middle temporal gyri in retrieving both the phonological and semantic code for words. The reading of pseudowords activates the left inferior frontal gyrus, including the ventral part of Broca’s area, to a larger extent than the reading of words. This suggests that this area might be involved in the sublexical conversion of orthographic input strings into phonological output codes. (Pre)motor areas were found to be activated during both silent reading and reading aloud. On the basis of the obtained activation patterns, it is hypothesized that the articulation of high-frequency syllables requires the retrieval of their concomitant articulatory gestures from the SMA and that the articulation of lowfrequency syllables recruits the left medial premotor cortex.
  • Hagoort, P. (1999). The uniquely human capacity for language communication: from 'pope' to [po:p] in half a second. In J. Russell, M. Murphy, T. Meyering, & M. Arbib (Eds.), Neuroscience and the person: Scientific perspectives on divine action (pp. 45-56). California: Berkeley.
  • Hagoort, P. (1992). Vertraagde lexicale integratie bij afatisch taalverstaan. Stem, Spraak- en Taalpathologie, 1, 5-23.
  • Härle, M., Dobel, C., Cohen, R., & Rockstroh, B. (2002). Brain activity during syntactic and semantic processing - a magnetoencephalographic study. Brain Topography, 15(1), 3-11. doi:10.1023/A:1020070521429.

    Abstract

    Drawings of objects were presented in series of 54 each to 14 German speaking subjects with the tasks to indicate by button presses a) whether the grammatical gender of an object name was masculine ("der") or feminine ("die") and b) whether the depicted object was man-made or nature-made. The magnetoencephalogram (MEG) was recorded with a whole-head neuromagnetometer and task-specific patterns of brain activity were determined in the source space (Minimum Norm Estimates, MNE). A left-temporal focus of activity 150-275 ms after stimulus onset in the gender decision compared to the semantic classification task was discussed as indicating the retrieval of syntactic information, while a more expanded left hemispheric activity in the gender relative to the semantic task 300-625 ms after stimulus onset was discussed as indicating phonological encoding. A predominance of activity in the semantic task was observed over right fronto-central region 150-225 ms after stimulus-onset, suggesting that semantic and syntactic processes are prominent in this stage of lexical selection.
  • Hayano, K. (2004). Kaiwa ni okeru ninshikiteki ken’i no koushou: Shuujoshi yo, ne, odoroki hyouji no bunpu to kinou [Negotiation of Epistemic Authority in Conversation: on the use of final particles yo, ne and surprise markers]. Studies in Pragmatics, 6, 17-28.
  • Heritage, J., & Stivers, T. (1999). Online commentary in acute medical visits: A method of shaping patient expectations. Social Science and Medicine, 49(11), 1501-1517. doi:10.1016/S0277-9536(99)00219-1.
  • Hoeks, J. C. J., Vonk, W., & Schriefers, H. (2002). Processing coordinated structures in context: The effect of topic-structure on ambiguity resolution. Journal of Memory and Language, 46(1), 99-119. doi:10.1006/jmla.2001.2800.

    Abstract

    When a sentence such as The model embraced the designer and the photographer laughed is read, the noun phrase the photographer is temporarily ambiguous: It can be either one of the objects of embraced (NP-coordination) or the subject of a new, conjoined sentence (S-coordination). It has been shown for a number of languages, including Dutch (the language used in this study), that readers prefer NP-coordination over S-coordination, at least in isolated sentences. In the present paper, it will be suggested that NP-coordination is preferred because it is the simpler of the two options in terms of topic-structure; in NP-coordinations there is only one topic, whereas S-coordinations contain two. Results from off-line (sentence completion) and online studies (a self-paced reading and an eye tracking experiment) support this topic-structure explanation. The processing difficulty associated with S-coordinated sentences disappeared when these sentences followed contexts favoring a two-topic continuation. This finding establishes topic-structure as an important factor in online sentence processing.
  • Hoiting, N., & Slobin, D. I. (2002). Transcription as a tool for understanding: The Berkeley Transcription System for sign language research (BTS). In G. Morgan, & B. Woll (Eds.), Directions in sign language acquisition (pp. 55-75). Amsterdam: John Benjamins.
  • Hoiting, N., & Slobin, D. I. (2002). What a deaf child needs to see: Advantages of a natural sign language over a sign system. In R. Schulmeister, & H. Reinitzer (Eds.), Progress in sign language research. In honor of Siegmund Prillwitz / Fortschritte in der Gebärdensprach-forschung. Festschrift für Siegmund Prillwitz (pp. 267-277). Hamburg: Signum.
  • Holler, J., & Beattie, G. (2002). A micro-analytic investigation of how iconic gestures and speech represent core semantic features in talk. Semiotica, 142, 31-69.
  • Holler, J., & Beattie, G. (2004). The interaction of iconic gesture and speech. In A. Cammurri, & G. Volpe (Eds.), Lecture Notes in Computer Science, 5th International Gesture Workshop, Genova, Italy, 2003; Selected Revised Papers (pp. 63-69). Heidelberg: Springer Verlag.
  • Horemans, I., & Schiller, N. O. (2004). Form-priming effects in nonword naming. Brain and Language, 90(1-3), 465-469. doi:10.1016/S0093-934X(03)00457-7.

    Abstract

    Form-priming effects from sublexical (syllabic or segmental) primes in masked priming can be accounted for in two ways. One is the sublexical pre-activation view according to which segments are pre-activated by the prime, and at the time the form-related target is to be produced, retrieval/assembly of those pre-activated segments is faster compared to an unrelated situation. However, it has also been argued that form-priming effects from sublexical primes might be due to lexical pre-activation. When the sublexical prime is presented, it activates all form-related words (i.e., cohorts) in the lexicon, necessarily including the form-related target, which—as a consequence—is produced faster than in the unrelated case. Note, however, that this lexical pre-activation account makes previous pre-lexical activation of segments necessary. This study reports a nonword naming experiment to investigate whether or not sublexical pre-activation is involved in masked form priming with sublexical primes. The results demonstrated a priming effect suggesting a nonlexical effect. However, this does not exclude an additional lexical component in form priming.
  • Hoymann, G. (2004). [Review of the book Botswana: The future of the minority languages ed. by Herman M. Batibo and Birgit Smieja]. Journal of African Languages and Linguistics, 25(2), 171-173. doi:10.1515/jall.2004.25.2.171.
  • Huettig, F., & Altmann, G. T. M. (2004). The online processing of ambiguous and unambiguous words in context: Evidence from head-mounted eye-tracking. In M. Carreiras, & C. Clifton (Eds.), The on-line study of sentence comprehension: Eyetracking, ERP and beyond (pp. 187-207). New York: Psychology Press.
  • Indefrey, P., & Cutler, A. (2004). Prelexical and lexical processing in listening. In M. Gazzaniga (Ed.), The cognitive neurosciences III. (pp. 759-774). Cambridge, MA: MIT Press.

    Abstract

    This paper presents a meta-analysis of hemodynamic studies on passive auditory language processing. We assess the overlap of hemodynamic activation areas and activation maxima reported in experiments involving the presentation of sentences, words, pseudowords, or sublexical or non-linguistic auditory stimuli. Areas that have been reliably replicated are identified. The results of the meta-analysis are compared to electrophysiological, magnetencephalic (MEG), and clinical findings. It is concluded that auditory language input is processed in a left posterior frontal and bilateral temporal cortical network. Within this network, no processing leve l is related to a single cortical area. The temporal lobes seem to differ with respect to their involvement in post-lexical processing, in that the left temporal lobe has greater involvement than the right, and also in the degree of anatomical specialization for phonological, lexical, and sentence -level processing, with greater overlap on the right contrasting with a higher degree of differentiation on the left.
  • Indefrey, P., & Levelt, W. J. M. (2004). The spatial and temporal signatures of word production components. Cognition, 92(1-2), 101-144. doi:10.1016/j.cognition.2002.06.001.

    Abstract

    This paper presents the results of a comprehensive meta-analysis of the relevant imaging literature on word production (82 experiments). In addition to the spatial overlap of activated regions, we also analyzed the available data on the time course of activations. The analysis specified regions and time windows of activation for the core processes of word production: lexical selection, phonological code retrieval, syllabification, and phonetic/articulatory preparation. A comparison of the word production results with studies on auditory word/non-word perception and reading showed that the time course of activations in word production is, on the whole, compatible with the temporal constraints that perception processes impose on the production processes they affect in picture/word interference paradigms.
  • Indefrey, P., & Levelt, W. J. M. (1999). A meta-analysis of neuroimaging experiments on word production. Neuroimage, 7, 1028.
  • Indefrey, P. (1998). De neurale architectuur van taal: Welke hersengebieden zijn betrokken bij het spreken. Neuropraxis, 2(6), 230-237.
  • Indefrey, P. (2004). Hirnaktivierungen bei syntaktischer Sprachverarbeitung: Eine Meta-Analyse. In H. Müller, & G. Rickheit (Eds.), Neurokognition der Sprache (pp. 31-50). Tübingen: Stauffenburg.
  • Indefrey, P., Hellwig, F. M., Herzog, H., Seitz, R. J., & Hagoort, P. (2004). Neural responses to the production and comprehension of syntax in identical utterances. Brain and Language, 89(2), 312-319. doi:10.1016/S0093-934X(03)00352-3.

    Abstract

    Following up on an earlier positron emission tomography (PET) experiment (Indefrey et al., 2001), we used a scene description paradigm to investigate whether a posterior inferior frontal region subserving syntactic encoding for speaking is also involved in syntactic parsing during listening. In the language production part of the experiment, subjects described visually presented scenes
    using either sentences, sequences of noun phrases, or sequences of syntactically unrelated words. In the language comprehension part of the experiment, subjects were auditorily presented with the same kinds of utterances and judged whether they matched the visual scenes. We were able to replicate the previous finding of a region in caudal Broca s area that is sensitive to the complexity of
    syntactic encoding in language production. In language comprehension, no hemodynamic activation differences due to syntactic complexity were found. Given that correct performance in the judgment task did not require syntactic processing of the auditory stimuli, the results suggest that the degree to which listeners recruit syntactic processing resources in language comprehension may be a function of the syntactic demands of the task or the stimulus material.
  • Indefrey, P., Gruber, O., Brown, C. M., Hagoort, P., Posse, S., & Kleinschmidt, A. (1998). Lexicality and not syllable frequency determine lateralized premotor activation during the pronunciation of word-like stimuli: An fMRI study. NeuroImage, 7, S4.
  • Indefrey, P. (1999). Some problems with the lexical status of nondefault inflection. Behavioral and Brain Sciences, 22(6), 1025. doi:10.1017/S0140525X99342229.

    Abstract

    Clahsen's characterization of nondefault inflection as based exclusively on lexical entries does not capture the full range of empirical data on German inflection. In the verb system differential effects of lexical frequency seem to be input-related rather than affecting morphological production. In the noun system, the generalization properties of -n and -e plurals exceed mere analogy-based productivity.
  • Ischebeck, A., Indefrey, P., Usui, N., Nose, I., Hellwig, F. M., & Taira, M. (2004). Reading in a regular orthography: An fMRI study investigating the role of visual familiarity. Journal of Cognitive Neuroscience, 16(5), 727-741. doi:10.1162/089892904970708.

    Abstract

    In order to separate the cognitive processes associated with phonological encoding and the use of a visual word form lexicon in reading, it is desirable to compare the processing of words presented in a visually familiar form with words in a visually unfamiliar form. Japanese Kana orthography offers this possibility. Two phonologically equivalent but visually dissimilar syllabaries allow the writing of, for example, foreign loanwords in two ways, only one of which is visually familiar. Familiarly written words, unfamiliarly written words, and pseudowords were presented in both Kana syllabaries (yielding six conditions in total) to participants during an fMRI measurement with a silent articulation task (Experiment 1) and a phonological lexical decision task (Experiment 2) using an event-related design. Consistent over two experimental tasks, the three different stimulus types (familiar, unfamiliar, and pseudoword) were found to activate selectively different brain regions previously associated with phonological encoding and word retrieval or meaning. Compatible with the predictions of the dual-route model for reading, pseudowords and visually unfamiliar words, which have to be read using phonological assembly, caused an increase in brain activity in left inferior frontal regions (BA 44/47), as compared to visually familiar words. Visually familiar and unfamiliar words were found to activate a range of areas associated with lexico-semantic processing more strongly than pseudowords, such as the left and right temporo-parietal region (BA 39/40), a region in the left middle/inferior temporal gyrus (BA 20/21), and the posterior cingulate (BA 31).
  • Janse, E., & Klitsch, J. (2004). Auditieve perceptie bij gezonde sprekers en bij sprekers met verworven taalstoornissen. Afasiologie, 26(1), 2-6.
  • Janse, E. (2004). Word perception in fast speech: Artificially time-compressed vs. naturally produced fast speech. Speech Communication, 42, 155-173. doi:10.1016/j.specom.2003.07.001.

    Abstract

    Natural fast speech differs from normal-rate speech with respect to its temporal pattern. Previous results showed that word intelligibility of heavily artificially time-compressed speech could not be improved by making its temporal pattern more similar to that of natural fast speech. This might have been due to the extrapolation of timing rules for natural fast speech to rates that are much faster than can be attained by human speakers. The present study investigates whether, at a speech rate that human speakers can attain, artificially time-compressed speech is easier to process if its timing pattern is similar to that of naturally produced fast speech. Our first experiment suggests, however, that word processing speed was slowed down, relative to linear compression. In a second experiment, word processing of artificially time-compressed speech was compared with processing of naturally produced fast speech. Even when naturally produced fast speech is perfectly intelligible, its less careful articulation, combined with the changed timing pattern, slows down processing, relative to linearly time-compressed speech. Furthermore, listeners preferred artificially time-compressed speech over naturally produced fast speech. These results suggest that linearly time-compressed speech has both a temporal and a segmental advantage over natural fast speech.
  • Jansma, B. M., & Schiller, N. O. (2004). Monitoring syllable boundaries during speech production. Brain and Language, 90(1-3), 311-317. doi:10.1016/S0093-934X(03)00443-7.

    Abstract

    This study investigated the encoding of syllable boundary information during speech production in Dutch. Based on Levelt's model of phonological encoding, we hypothesized segments and syllable boundaries to be encoded in an incremental way. In a selfmonitoring experiment, decisions about the syllable affiliation (first or second syllable) of a pre-specified consonant, which was the third phoneme in a word, were required (e.g., ka.No canoe vs. kaN.sel pulpit ; capital letters indicate pivotal consonants, dots mark syllable boundaries). First syllable responses were faster than second syllable responses, indicating the incremental nature of segmental encoding and syllabification during speech production planning. The results of the experiment are discussed in the context of Levelt 's model of phonological encoding.
  • Janssen, D. P., Roelofs, A., & Levelt, W. J. M. (2004). Stem complexity and inflectional encoding in language production. Journal of Psycholinguistic Research, 33(5), 365-381. doi:10.1023/B:JOPR.0000039546.60121.a8.

    Abstract

    Three experiments are reported that examined whether stem complexity plays a role in inflecting polymorphemic words in language production. Experiment 1 showed that preparation effects for words with polymorphemic stems are larger when they are produced among words with constant inflectional structures compared to words with variable inflectional structures and simple stems. This replicates earlier findings for words with monomorphemic stems (Janssen et al., 2002). Experiments 2 and 3 showed that when inflectional structure is held constant, the preparation effects are equally large with simple and compound stems, and with compound and complex adjectival stems. These results indicate that inflectional encoding is blind to the complexity of the stem, which suggests that specific inflectional rather than generic morphological frames guide the generation of inflected forms in speaking words.
  • Janssen, D. P., Roelofs, A., & Levelt, W. J. M. (2002). Inflectional frames in language production. Language and Cognitive Processes, 17(3), 209-236. doi:10.1006/jmla.2001.2800.

    Abstract

    The authors report six implicit priming experiments that examined the production of inflected forms. Participants produced words out of small sets in response to prompts. The words differed in form or shared word-initial segments, which allowed for preparation. In constant inflectional sets, the words had the same number of inflectional suffixes, whereas in variable sets the number of suffixes differed. In the experiments, preparation effects were obtained, which were larger in the constant than in the variable sets. Control experiments showed that this difference in effect was not due to syntactic class or phonological form per se. The results are interpreted in terms of a slot-and-filler model of word production, in which inflectional frames, on the one hand, and stems and affixes, on the other hand, are independently spelled out on the basis of an abstract morpho-syntactic specification of the word, which is followed by morpheme-to-frame association.
  • Janzen, G., & Van Turennout, M. (2004). Selective neural representation of objects relevant for navigation. Nature Neuroscience, 7(6), 673-677. doi:10.1038/nn1257.

    Abstract

    As people find their way through their environment, objects at navigationally relevant locations can serve as crucial landmarks. The parahippocampal gyrus has previously been shown to be involved in object and scene recognition. In the present study, we investigated the neural representation of navigationally relevant locations. Healthy human adults viewed a route through a virtual museum with objects placed at intersections (decision points) or at simple turns (non-decision points). Event-related functional magnetic resonance imaging (fMRI) data were acquired during subsequent recognition of the objects in isolation. Neural activity in the parahippocampal gyrus reflected the navigational relevance of an object's location in the museum. Parahippocampal responses were selectively increased for objects that occurred at decision points, independent of attentional demands. This increase occurred for forgotten as well as remembered objects, showing implicit retrieval of navigational information. The automatic storage of relevant object location in the parahippocampal gyrus provides a part of the neural mechanism underlying successful navigation.
  • De Jong, N. H., Feldman, L. B., Schreuder, R., Pastizzo, M., & Baayen, R. H. (2002). The processing and representation of Dutch and English compounds: Peripheral morphological, and central orthographic effects. Brain and Language, 81(1-3), 555-567. doi:10.1006/brln.2001.2547.

    Abstract

    In this study, we use the association between various measures of the morphological family and decision latencies to reveal the way in which the components of Dutch and English compounds are processed. The results show that for constituents of concatenated compounds in both languages, a position-related token count of the morphological family plays a role, whereas English open compounds show an effect of a type count, similar to the effect of family size for simplex words. When Dutch compounds are written with an artificial space, they reveal no effect of type count, which shows that the differential effect for the English open compounds is not superficial. The final experiment provides converging evidence for the lexical consequences of the space in English compounds. Decision latencies for English simplex words are better predicted from counts of the morphological family that include concatenated and hyphenated but not open family members.
  • Jordens, P. (2004). Systematiek en dynamiek bij de verwerving van Finietheid. Toegepaste Taalwetenschap in Artikelen, 71, 9-22.

    Abstract

    In early Dutch learner varieties, there is no evidence of finiteness being a functional category. There is no V2nd: no correlation between inflectional morphology and movement. Initially, learners express the illocutive function of finiteness through the use of illocutive markers, with the non-use of an illocutive marker expressing the default illocutive function of assertion. Illocutive markers are functioning as adjuncts with scope over the predicate. Illocutive markers become re-analysed as functional elements.The driving force is the acquisition of the auxiliary verbs that occur with past participles. It leads to a reanalysis of illocutive markers as two separate elements: an auxiliary verb and a scope adverb. The (modal) auxiliary carries illocutive function. Lexical verb-argument structure (including the external argument) occurs within the domain of the auxiliary verb. The predicate as the focus constituent occurs within the domain of a scope adverb. This reanalysis establishes a position for the external argument within the domain of AUX. The acquisition of AUX causes the acquisition of a (hierarchical) structure with a complement as a constituent which represents an underlying verb-argument structure, a predicate as the domain of elements that are in focus, and an external (specifier) position as a landing site for elements with topic function.
  • Jordens, P. (1998). Defaultformen des Präteritums. Zum Erwerb der Vergangenheitsmorphologie im Niederlänidischen. In H. Wegener (Ed.), Eine zweite Sprache lernen (pp. 61-88). Tübingen, Germany: Verlag Gunter Narr.
  • Jordens, P. (2002). Finiteness in early child Dutch. Linguistics, 40(4), 687-765. doi:10.1515/ling.2002.029.
  • Jordens, P. (2004). Morphology in Second Language Acquisition. In G. Booij (Ed.), Morphologie: Ein internationales Handbuch zur Flexion und Wortbildung (pp. 1806-1816). Berlin: Walter de Gruyter.
  • Kempen, G. (2004). Terug naar Wundt: Pleidooi voor integraal onderzoek van taal, taalkennis en taalgedrag. In Koninklijke Nederlandse Akademie van Wetenschappen (Ed.), Gij letterdames en gij letterheren': Nieuwe mogelijkheden voor taalkundig en letterkundig onderzoek in Nederland. (pp. 174-188). Amsterdam: Koninklijke Nederlandse Akademie van Wetenschappen.
  • Kempen, G., & Harbusch, K. (2002). Performance Grammar: A declarative definition. In A. Nijholt, M. Theune, & H. Hondorp (Eds.), Computational linguistics in the Netherlands 2001: Selected papers from the Twelfth CLIN Meeting (pp. 148-162). Amsterdam: Rodopi.

    Abstract

    In this paper we present a definition of Performance Grammar (PG), a psycholinguistically motivated syntax formalism, in declarative terms. PG aims not only at describing and explaining intuitive judgments and other data concerning the well–formedness of sentences of a language, but also at contributing to accounts of syntactic processing phenomena observable in language comprehension and language production. We highlight two general properties of human sentence generation, incrementality and late linearization,which make special demands on the design of grammar formalisms claiming psychological plausibility. In order to meet these demands, PG generates syntactic structures in a two-stage process. In the first and most important ‘hierarchical’ stage, unordered hierarchical structures (‘mobiles’) are assembled out of lexical building blocks. The key operation at work here is typed feature unification, which also delimits the positional options of the syntactic constituents in terms of so-called topological features. The second, much simpler stage takes care of arranging the branches of the mobile from left to right by ‘reading–out’ one positional option of every constituent. In this paper we concentrate on the structure assembly formalism in PG’s hierarchical component. We provide a declarative definition couched in an HPSG–style notation based on typed feature unification. Our emphasis throughout is on linear order constraints.
  • Kempen, G., & Vosse, T. (1992). A language-sensitive text editor for Dutch. In P. O’Brian Holt, & N. Williams (Eds.), Computers and writing: State of the art (pp. 68-77). Dordrecht: Kluwer Academic Publishers.

    Abstract

    Modern word processors begin to offer a range of facilities for spelling, grammar and style checking in English. For the Dutch language hardly anything is available as yet. Many commercial word processing packages do include a hyphenation routine and a lexicon-based spelling checker but the practical usefulness of these tools is limited due to certain properties of Dutch orthography, as we will explain below. In this chapter we describe a text editor which incorporates a great deal of lexical, morphological and syntactic knowledge of Dutch and monitors the orthographical quality of Dutch texts. Section 1 deals with those aspects of Dutch orthography which pose problems to human authors as well as to computational language sensitive text editing tools. In section 2 we describe the design and the implementation of the text editor we have built. Section 3 is mainly devoted to a provisional evaluation of the system.
  • Kempen, G. (1998). Comparing and explaining the trajectories of first and second language acquisition: In search of the right mix of psychological and linguistic factors [Commentory]. Bilingualism: Language and Cognition, 1, 29-30. doi:10.1017/S1366728998000066.

    Abstract

    When you compare the behavior of two different age groups which are trying to master the same sensori-motor or cognitive skill, you are likely to discover varying learning routes: different stages, different intervals between stages, or even different orderings of stages. Such heterogeneous learning trajectories may be caused by at least six different types of factors: (1) Initial state: the kinds and levels of skills the learners have available at the onset of the learning episode. (2) Learning mechanisms: rule-based, inductive, connectionist, parameter setting, and so on. (3) Input and feedback characteristics: learning stimuli, information about success and failure. (4) Information processing mechanisms: capacity limitations, attentional biases, response preferences. (5) Energetic variables: motivation, emotional reactions. (6) Final state: the fine-structure of kinds and levels of subskills at the end of the learning episode. This applies to language acquisition as well. First and second language learners probably differ on all six factors. Nevertheless, the debate between advocates and opponents of the Fundamental Difference Hypothesis concerning L1 and L2 acquisition have looked almost exclusively at the first two factors. Those who believe that L1 learners have access to Universal Grammar whereas L2 learners rely on language processing strategies, postulate different learning mechanisms (UG parameter setting in L1, more general inductive strategies in L2 learning). Pienemann opposes this view and, based on his Processability Theory, argues that L1 and L2 learners start out from different initial states: they come to the grammar learning task with different structural hypotheses (SOV versus SVO as basic word order of German).
  • Kempen, G., & Harbusch, K. (2004). A corpus study into word order variation in German subordinate clauses: Animacy affects linearization independently of grammatical function assignment. In T. Pechmann, & C. Habel (Eds.), Multidisciplinary approaches to language production (pp. 173-181). Berlin: Mouton de Gruyter.
  • Kempen, G., & Harbusch, K. (2004). Generating natural word orders in a semi-free word order language: Treebank-based linearization preferences for German. In A. Gelbukh (Ed.), Computational Linguistics and Intelligent Text Processing (pp. 350-354). Berlin: Springer.

    Abstract

    We outline an algorithm capable of generating varied but natural sounding sequences of argument NPs in subordinate clauses of German, a semi-free word order language. In order to attain the right level of output flexibility, the algorithm considers (1) the relevant lexical properties of the head verb (not only transitivity type but also reflexivity, thematic relations expressed by the NPs, etc.), and (2) the animacy and definiteness values of the arguments, and their length. The relevant statistical data were extracted from the NEGRA–II treebank and from hand-coded features for animacy and definiteness. The algorithm maps the relevant properties onto “primary” versus “secondary” placement options in the generator. The algorithm is restricted in that it does not take into account linear order determinants related to the sentence’s information structure and its discourse context (e.g. contrastiveness). These factors may modulate the above preferences or license “tertiary” linear orders beyond the primary and secondary options considered here.
  • Kempen, G. (1999). Fiets en (centri)fuge. Onze Taal, 68, 88.
  • Kempen, G. (1992). Generation. In W. Bright (Ed.), International encyclopedia of linguistics (pp. 59-61). New York: Oxford University Press.
  • Kempen, G. (1970). Ideaalbeelden van de Europese jeugd: Weerwoord op methodologische kritiek. Dux, 37, 54-56.
  • Kempen, G. (1992). Language technology and language instruction: Computational diagnosis of word level errors. In M. Swartz, & M. Yazdani (Eds.), Intelligent tutoring systems for foreign language learning: The bridge to international communication (pp. 191-198). Berlin: Springer.
  • Kempen, G. (1992). Grammar based text processing. Document Management: Nieuwsbrief voor Documentaire Informatiekunde, 1(2), 8-10.
  • Kempen, G. (1998). Sentence parsing. In A. D. Friederici (Ed.), Language comprehension: A biological perspective (pp. 213-228). Berlin: Springer.
  • Kempen, G. (1992). Second language acquisition as a hybrid learning process. In F. Engel, D. Bouwhuis, T. Bösser, & G. d'Ydewalle (Eds.), Cognitive modelling and interactive environments in language learning (pp. 139-144). Berlin: Springer.
  • Kempen, G. (1999). Visual Grammar: Multimedia for grammar and spelling instruction in primary education. In K. Cameron (Ed.), CALL: Media, design, and applications (pp. 223-238). Lisse: Swets & Zeitlinger.
  • Kemps, R. J. J. K., Ernestus, M., Schreuder, R., & Baayen, R. H. (2004). Processing reduced word forms: The suffix restoration effect. Brain and Language, 90(1-3), 117-127. doi:10.1016/S0093-934X(03)00425-5.

    Abstract

    Listeners cannot recognize highly reduced word forms in isolation, but they can do so when these forms are presented in context (Ernestus, Baayen, & Schreuder, 2002). This suggests that not all possible surface forms of words have equal status in the mental lexicon. The present study shows that the reduced forms are linked to the canonical representations in the mental lexicon, and that these latter representations induce reconstruction processes. Listeners restore suffixes that are partly or completely missing in reduced word forms. A series of phoneme-monitoring experiments reveals the nature of this restoration: the basis for suffix restoration is mainly phonological in nature, but orthography has an influence as well.
  • Kidd, E., & Bavin, E. L. (2002). English-speaking children's comprehension of relative clauses: Evidence for general-cognitive and language-specific constraints on development. Journal of Psycholinguistic Research, 31(6), 599-617. doi:10.1023/A:1021265021141.

    Abstract

    Children must possess some ability to process input in a meaningful manner to acquire language. The present study reports on data from an experiment investigating 3- to 5-year-old English-speaking children's understanding of restrictive relative clauses manipulated for embeddedness and focus. The results of the study showed that English-speaking children acquire right-branching before center-embedded structures. Comparisons made with data from Portuguese-speaking children suggest general-cognitive and language-specific constraints on development, and with respect to English, a “clause expansion” approach to processing in development
  • Kidd, E. (2004). Grammars, parsers, and language acquisition. Journal of Child Language, 31(2), 480-483. doi:10.1017/S0305000904006117.

    Abstract

    Drozd's critique of Crain & Thornton's (C&T) (1998) book Investigations in Universal Grammar (IUG) raises many issues concerning theory and experimental design within generative approaches to language acquisition. I focus here on one of the strongest theoretical claims of the Modularity Matching Model (MMM): continuity of processing. For reasons different to Drozd, I argue that the assumption is tenuous. Furthermore, I argue that the focus of the MMM and the methodological prescriptions contained in IUG are too narrow to capture language acquisition.
  • Kircher, T. T. J., Brammer, M. J., Levelt, W. J. M., Bartels, M., & McGuire, P. K. (2004). Pausing for thought: Engagement of left temporal cortex during pauses in speech. NeuroImage, 21(1), 84-90. doi:10.1016/j.neuroimage.2003.09.041.

    Abstract

    Pauses during continuous speech, particularly those that occur within clauses, are thought to reflect the planning of forthcoming verbal output. We used functional Magnetic Resonance Imaging (fMRI) to examine their neural correlates. Six volunteers were scanned while describing seven Rorschach inkblots, producing 3 min of speech per inkblot. In an event-related design, the level of blood oxygenation level dependent (BOLD) contrast during brief speech pauses (mean duration 1.3 s, SD 0.3 s) during overt speech was contrasted with that during intervening periods of articulation. We then examined activity associated with pauses that occurred within clauses and pauses that occurred between grammatical junctions. Relative to articulation during speech, pauses were associated with activation in the banks of the left superior temporal sulcus (BA 39/22), at the temporoparietal junction. Continuous speech was associated with greater activation bilaterally in the inferior frontal (BA 44/45), middle frontal (BA 8) and anterior cingulate (BA 24) gyri, the middle temporal sulcus (BA 21/22), the occipital cortex and the cerebellum. Left temporal activation was evident during pauses that occurred within clauses but not during pauses at grammatical junctions. In summary, articulation during continuous speech involved frontal, temporal and cerebellar areas, while pausing was associated with activity in the left temporal cortex, especially when this occurred within a clause. The latter finding is consistent with evidence that within-clause pauses are a correlate of speech planning and in particular lexical retrieval.
  • Kirsch, K., & Dittmar, N. (2002). [Review of the book Russlanddeutsche Sprachbiografien: Untersuchungen zur sprachlichen Integration von Aussiedlerfamilien by Katharina Meng]. Zeitschrift für Sprachwissenschaft, 21, 295-296.
  • Kita, S., & Ozyurek, A. (1999). Semantische Koordination zwischen Sprache und spontanen ikonischen Gesten: Eine sprachvergleichende Untersuchung. In Max-Planck-Gesellschaft (Ed.), Jahrbuch 1998 (pp. 388-391). Göttingen: Vandenhoeck & Ruprecht.
  • Kita, S. (2002). Preface and priorities. In S. Kita (Ed.), 2002 Supplement (version 3) for the “Manual” for the field season 2001 (pp. 3-4). Nijmegen: Max Planck Institute for Psycholinguistics.
  • Klein, W., & Von Stutterheim, C. (2002). Quaestio and L-perspectivation. In C. F. Graumann, & W. Kallmeyer (Eds.), Perspective and perspectivation in discourse (pp. 59-88). Amsterdam: Benjamins.
  • Klein, W. (2002). The argument-time structure of recipient constructions in German. In W. Abraham, & J.-W. Zwart (Eds.), Issues in formal german(ic) typology (pp. 141-178). Amsterdam: Benjamins.

    Abstract

    It is generally assumed that verbs have an ‘argument structure’, which imposes various constraints on the noun phrases that can or must go with the verb, and an ‘event structure’, which characterises the particular temporal characteristics of the ‘event’ which the verb relates to: this event may be a state, a process, an activity, an ‘event in the narrow sense’, and others. In this paper, it is argued that that argument structure and event structure should be brought together. The lexical content of a verb assigns descriptive properties to one or more arguments at one or more times, hence verbs have an ‘argument time-structure’ (AT-structure). Numerous morphological and syntactical operations, such as participle formation or complex verb constructions, modify this AT-structure. This is illustrated with German recipient constructions such as ein Buch geschenkt bekommen or das Fenster geöffnet kriegen.
  • Klein, W. (2004). Vom Wörterbuch zum digitalen lexikalischen System. Zeitschrift für Literaturwissenschaft und Linguistik, 136, 10-55.
  • Klein, W. (2002). Why case marking? In I. Kaufmann, & B. Stiebels (Eds.), More than words: Festschrift for Dieter Wunderlich (pp. 251-273). Berlin: Akademie Verlag.
  • Klein, W. (1992). Der Fall Horten gegen Delius, oder: Der Laie, der Fachmann und das Recht. In G. Grewendorf (Ed.), Rechtskultur als Sprachkultur: Zur forensischen Funktion der Sprachanalyse (pp. 284-313). Frankfurt am Main: Suhrkamp.
  • Klein, W. (1998). Ein Blick zurück auf die Varietätengrammatik. In U. Ammon, K. Mattheier, & P. Nelde (Eds.), Sociolinguistica: Internationales Jahrbuch für europäische Soziolinguistik (pp. 22-38). Tübingen: Niemeyer.
  • Klein, W. (1992). Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, 22(86), 7-8.
  • Klein, W. (1999). Die Lehren des Zweitspracherwerbs. In N. Dittmar, & A. Ramat (Eds.), Grammatik und Diskurs: Studien zum Erwerb des Deutschen und des Italienischen (pp. 279-290). Tübingen: Stauffenberg.
  • Klein, W. (1998). Assertion and finiteness. In N. Dittmar, & Z. Penner (Eds.), Issues in the theory of language acquisition: Essays in honor of Jürgen Weissenborn (pp. 225-245). Bern: Peter Lang.
  • Klein, W. (2004). Das Digitale Wörterbuch der deutschen Sprache des 20. Jahrhunderts (DWDS). In J. Scharnhorst (Ed.), Sprachkultur und Lexikographie (pp. 281-311). Berlin: Peter Lang.
  • Klein, W. (1970). Eine Analysegrammatik. Linguistische Berichte, (10), 13-16.
  • Klein, W., & Jungbluth, K. (2002). Einleitung - Introduction. Zeitschrift für Literaturwissenschaft und Linguistik, 125, 5-9.
  • Klein, W. (2004). Auf der Suche nach den Prinzipien, oder: Warum die Geisteswissenschaften auf dem Rückzug sind. Zeitschrift für Literaturwissenschaft und Linguistik, 134, 19-44.
  • Klein, W., & Musan, R. (2002). (A)Symmetry in language: seit and bis, and others. In C. Maienborn (Ed.), (A)Symmetrien - (A)Symmetry. Beiträge zu Ehren von Ewald Lang - Papers in Honor of Ewald Lang (pp. 283-295). Tübingen: Stauffenburg.
  • Klein, W. (2004). Im Lauf der Jahre. Linguistische Berichte, 200, 397-407.
  • Klein, W., & Perdue, C. (1992). Framework. In W. Klein, & C. Perdue (Eds.), Utterance structure: Developing grammars again (pp. 11-59). Amsterdam: Benjamins.
  • Klein, W. (1992). Tempus, Aspekt und Zeitadverbien. Kognitionswissenschaft, 2, 107-118.
  • Klein, W., & Von Stutterheim, C. (1992). Textstruktur und referentielle Bewegung. Zeitschrift für Literaturwissenschaft und Linguistik, 86, 67-92.
  • Klein, W., & Carroll, M. (1992). The acquisition of German. In W. Klein, & C. Perdue (Eds.), Utterance structure: Developing grammars again (pp. 123-188). Amsterdam: Benjamins.
  • Klein, W. (1998). The contribution of second language acquisition research. Language Learning, 48, 527-550. doi:10.1111/0023-8333.00057.

    Abstract

    During the last 25 years, second language acquisition (SLA) research hasmade considerable progress, but is still far from proving a solid basis for foreign language teaching, or from a general theory of SLA. In addition, its status within the linguistic disciplines is still very low. I argue this has not much to do with low empirical or theoretical standards in the field—in this regard, SLA research is fully competitive—but with a particular perspective on the acquisition process: SLA researches learners' utterances as deviations from a certain target, instead of genuine manifestations of underlying language capacity; it analyses them in terms of what they are not rather than what they are. For some purposes such a "target deviation perspective" makes sense, but it will not help SLA researchers to substantially and independently contribute to a deeper understanding of the structure and function of the human language faculty. Therefore, these findings will remain of limited interest to other scientists until SLA researchers consider learner varieties a normal, in fact typical, manifestation of this unique human capacity.
  • Klein, W., & Vater, H. (1998). The perfect in English and German. In L. Kulikov, & H. Vater (Eds.), Typology of verbal categories: Papers presented to Vladimir Nedjalkov on the occasion of his 70th birthday (pp. 215-235). Tübingen: Niemeyer.
  • Klein, W. (1992). The present perfect puzzle. Language, 68, 525-552.

    Abstract

    In John has left London, it is clear that the event in question, John's leaving London, has occurred in the past, for example yesterday at ten. Why is it impossible, then, to make this the event time more explicit by such an adverbial, as in Yesterday at ten, John has left London? Any solution of this puzzle crucially hinges on the meaning assigned to the perfect, and the present perfect in particular. Two such solutions, a scope solution and the 'current relevance'-solution, are discussed and shown to be inadequate. A new, strictly compositional analysis of the English perfect is suggested, and it is argued that the imcompatibility of the present perfect and most past tense adverbials has neither syntactic nor semantic reasons but follows from a simple pragmatical constraint, called here the 'position-definiteness constraint'. It is the very same constraint, which also makes an utterance such as At ten, John had left at nine pragmatically odd, even if John indeed had left at nine, and hence the utterance is true.
  • Klein, W. (2004). Was die Geisteswissenschaften leider noch von den Naturwissenschaften unterscheidet. Gegenworte, 13, 79-84.
  • Klein, W. (1999). Wie sich das deutsche Perfekt zusammensetzt. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, (113), 52-85.
  • Klein, W., & Zimmermann, H. (1970). Trakl. Versuche zur maschinellen Analyse von Dichtersprache. Sprachkunst, 1(1/2), 122-139.
  • Klein, W. (1998). Von der einfältigen Wißbegierde. Zeitschrift für Literaturwissenschaft und Linguistik, 112, 6-13.
  • Knosche, T. R., & Bastiaansen, M. C. M. (2002). On the time resolution of event-related desynchronization: A simulation study. Clinical Neurophysiology, 113(5), 754-763. doi:10.1016/S1388-2457(02)00055-X.

    Abstract

    Objectives: To investigate the time resolution of different methods for the computation of event-related desynchronization/synchronization (ERD/ERS), including one based on Hilbert transform. Methods: In order to better understand the time resolution of ERD/ERS, which is a function of factors such as the exact computation method, the frequency under study, the number of trials, and the sampling frequency, we simulated sudden changes in oscillation amplitude as well as very short and closely spaced events. Results: Hilbert-based ERD yields very similar results to ERD integrated over predefined time intervals (block ERD), if the block length is half the period length of the studied frequency. ERD predicts the onset of a change in oscillation amplitude with an error margin of only 10–30 ms. On the other hand, the time the ERD response needs to climb to its full height after a sudden change in oscillation amplitude is quite long, i.e. between 200 and 500 ms. With respect to sensitivity to short oscillatory events, the ratio between sampling frequency and electroencephalographic frequency band plays a major role. Conclusions: (1) The optimal time interval for the computation of block ERD is half a period of the frequency under investigation. (2) Due to the slow impulse response, amplitude effects in the ERD may in reality be caused by duration differences. (3) Although ERD based on the Hilbert transform does not yield any significant advantages over classical ERD in terms of time resolution, it has some important practical advantages.
  • Köster, O., Hess, M. M., Schiller, N. O., & Künzel, H. J. (1998). The correlation between auditory speech sensitivity and speaker recognition ability. Forensic Linguistics: The international Journal of Speech, Language and the Law, 5, 22-32.

    Abstract

    In various applications of forensic phonetics the question arises as to how far aural-perceptual speaker recognition performance is reliable. Therefore, it is necessary to examine the relationship between speaker recognition results and human perception/production abilities like musicality or speech sensitivity. In this study, performance in a speaker recognition experiment and a speech sensitivity test are correlated. The results show a moderately significant positive correlation between the two tasks. Generally, performance in the speaker recognition task was better than in the speech sensitivity test. Professionals in speech and singing yielded a more homogeneous correlation than non-experts. Training in speech as well as choir-singing seems to have a positive effect on performance in speaker recognition. It may be concluded, firstly, that in cases where the reliability of voice line-up results or the credibility of a testimony have to be considered, the speech sensitivity test could be a useful indicator. Secondly, the speech sensitivity test might be integrated into the canon of possible procedures for the accreditation of forensic phoneticians. Both tests may also be used in combination.
  • Krämer, I. (1998). Children's interpretations of indefinite object noun phrases. Linguistics in the Netherlands, 1998, 163-174. doi:10.1075/avt.15.15kra.
  • Krott, A., Hagoort, P., & Baayen, R. H. (2004). Sublexical units and supralexical combinatories in the processing of interfixed Dutch compounds. Language and Cognitive Processes, 19(3), 453-471. doi:10.1080/769813936.

    Abstract

    This study addresses the supralexical inferential processes underlying wellformedness judgements and latencies for a specic sublexical unit that appears in Dutch compounds, the interfix. Production studies have shown that the selection of interfixes in novel Dutch compounds and the speed of
    this selection is primarily determined by the distribution of interfixes in existing compounds that share the left constituent with the target compound, i.e. the ‘‘left constituent family’’. In this paper, we consider the question whether constituent families also affect wellformedness decisions of novel as well as existing Dutch compounds in comprehension. We visually presented compounds containing interfixes that were either in line with the bias of the left constituent family or not. In the case of existing compounds, we also presented variants with replaced interfixes. As in production, the bias of the left constituent family emerged as a crucial predictor for both acceptance rates and response latencies. This result supports the hypothesis that, as in production, constituent families are (co-)activated in comprehension. We argue that this co-activation is part of a supralexical inferential process, and we discuss how our data might be interpreted within sublexical and supralexical theories of morphological processing.
  • Krott, A., Libben, G., Jarema, G., Dressler, W., Schreuder, R., & Baayen, R. H. (2004). Probability in the grammar of German and Dutch: Interfixation in triconstituent compounds. Language and Speech, 47(1), 83-106.

    Abstract

    This study addresses the possibility that interfixes in multiconstituent nominal compounds in German and Dutch are functional as markers of immediate constituent structure.We report a lexical statistical survey of interfixation in the lexicons of German and Dutch which shows that all interfixes of German and one interfix of Dutch are significantly more likely to appear at the major constituent boundary than expected under chance conditions. A series of experiments provides evidence that speakers of German and Dutch are sensitive to the probabilistic cues to constituent structure provided by the interfixes. Thus, our data provide evidence that probability is part and parcel of grammatical competence.
  • Krott, A., Schreuder, R., & Baayen, R. H. (2002). Analogical hierarchy: Exemplar-based modeling of linkers in Dutch noun-noun compounds. In R. Skousen (Ed.), Analogical modeling: An exemplar-based approach to language (pp. 181-206). Amsterdam: Benjamins.
  • Kuijpers, C. T., Coolen, R., Houston, D., & Cutler, A. (1998). Using the head-turning technique to explore cross-linguistic performance differences. In C. Rovee-Collier, L. Lipsitt, & H. Hayne (Eds.), Advances in infancy research: Vol. 12 (pp. 205-220). Stamford: Ablex.
  • Küntay, A. C., & Slobin, D. I. (2002). Putting interaction back into child language: Examples from Turkish. Psychology of Language and Communication, 6(1): 14.

    Abstract

    As in the case of other non-English languages, the study of the acquisition of Turkish has mostly focused on aspects of grammatical morphology and syntax, largely neglecting the study of the effect of interactional factors on child morphosyntax. This paper reviews indications from past research that studying input and adult-child discourse can facilitate the study of the acquisition of morphosyntax in the Turkish language. It also provides some recent studies of Turkish child language on the relationship of child-directed speech to the early acquisition of morphosyntax, and on the pragmatic features of a certain kind of discourse form in child-directed speech called variation sets.
  • De Lange, F. P., Kalkman, J. S., Bleijenberg, G., Hagoort, P., Van der Werf, S. P., Van der Meer, J. W. M., & Toni, I. (2004). Neural correlates of the chronic fatigue syndrom: An fMRI study. Brain, 127(9), 1948-1957. doi:10.1093/brain/awh225.

    Abstract

    Chronic fatigue syndrome (CFS) is characterized by a debilitating fatigue of unknown aetiology. Patients who suffer from CFS report a variety of physical complaints as well as neuropsychological complaints. Therefore, it is conceivable that the CNS plays a role in the pathophysiology of CFS. The purpose of this study was to investigate neural correlates of CFS, and specifically whether there exists a linkage between disturbances in the motor system and CFS. We measured behavioural performance and cerebral activity using rapid event-related functional MRI in 16 CFS patients and 16 matched healthy controls while they were engaged in a motor imagery task and a control visual imagery task. CFS patients were considerably slower on performance of both tasks, but the increase in reaction time with increasing task load was similar between the groups. Both groups used largely overlapping neural resources. However, during the motor imagery task, CFS patients evoked stronger responses in visually related structures. Furthermore, there was a marked between-groups difference during erroneous performance. In both groups, dorsal anterior cingulate cortex was specifically activated during error trials. Conversely, ventral anterior cingulate cortex was active when healthy controls made an error, but remained inactive when CFS patients made an error. Our results support the notion that CFS may be associated with dysfunctional motor planning. Furthermore, the between-groups differences observed during erroneous performance point to motivational disturbances as a crucial component of CFS.

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