Publications

Abstract

Retaining detailed representations of unstressed syllables is a logical prerequisite for infants' use of probabilistic phonotactics to segment iambic words from fluent speech. The head-turn preference study was used to investigate the nature of English- learners' representations of iambic word onsets. Fifty-four 10.5-month-olds were familiarized to passages containing the nonsense iambic word forms ginome and tupong. Following familiarization, infants were either tested on familiar (ginome and tupong) or near-familiar (pinome and bupong) versus unfamiliar (kidar and mafoos) words. Infants in the familiar test group (familiar vs. unfamiliar) oriented significantly longer to familiar than unfamiliar test items, whereas infants in the near-familiar test group (near-familiar vs. unfamiliar) oriented equally long to near-familiar and unfamiliar test items. Our results provide evidence that infants retain fairly detailed representations of unstressed syllables and therefore support the hypothesis that infants use phonotactic cues to find words in fluent speech.

Abstract

Whereas it has long been assumed that most linguistic processes underlying language production happen automatically, accumulating evidence suggests that some form of attention is required. Here, we investigated the contribution of sustained attention, which is the ability to maintain alertness over time. First, the sustained attention ability of participants was measured using auditory and visual continuous performance tasks. Next, the participants described pictures using simple noun phrases while their response times (RTs) and gaze durations were measured. Earlier research has suggested that gaze duration reflects language planning processes up to and including phonological encoding. Individual differences in sustained attention ability correlated with individual differences in the magnitude of the tail of the RT distribution, reflecting the proportion of very slow responses, but not with individual differences in gaze duration. These results suggest that language production requires sustained attention, especially after phonological encoding.

Abstract

It has previously been shown that language production, performed simultaneously with a nonlinguistic task, involves sustained attention. Sustained attention concerns the ability to maintain alertness over time. Here, we aimed to replicate the previous finding by showing that individuals call upon sustained attention when they plan single noun phrases (e.g., "the carrot") and perform a manual arrow categorization task. In addition, we investigated whether speakers also recruit sustained attention when they produce conjoined noun phrases (e.g., "the carrot and the bucket") describing two pictures, that is, when both the first and second task are linguistic. We found that sustained attention correlated with the proportion of abnormally slow phrase-production responses. Individuals with poor sustained attention displayed a greater number of very slow responses than individuals with better sustained attention. Importantly, this relationship was obtained both for the production of single phrases while performing a nonlinguistic manual task, and the production of noun phrase conjunctions in referring to two spatially separated objects. Inhibition and updating abilities were also measured. These scores did not correlate with our measure of sustained attention, suggesting that sustained attention and executive control are distinct. Overall, the results suggest that planning conjoined noun phrases involves sustained attention, and that language production happens less automatically than has often been assumed.

Abstract

Recent behavioral and electrophysiological evidence has highlighted the long-term importance for language skills of an early ability to recognize words in continuous speech. We here present further tests of this long-term link in the form of follow-up studies conducted with two (separate) groups of infants who had earlier participated in speech segmentation tasks. Each study extends prior follow-up tests: Study 1 by using a novel follow-up measure that taps into online processing, Study 2 by assessing language performance relationships over a longer time span than previously tested. Results of Study 1 show that brain correlates of speech segmentation ability at 10 months are positively related to 16-month-olds’ target fixations in a looking-while-listening task. Results of Study 2 show that infant speech segmentation ability no longer directly predicts language profiles at the age of five. However, a meta-analysis across our results and those of similar studies (Study 3) reveals that age at follow-up does not moderate effect size. Together, the results suggest that infants’ ability to recognize words in speech certainly benefits early vocabulary development; further observed relationships of later language skills to early word recognition may be consequent upon this vocabulary size effect.

Abstract

Most words that infants hear occur within fluent speech. To compile a vocabulary, infants therefore need to segment words from speech contexts. This study is the first to investigate whether infants (here: 10-month-olds) can recognize words when both initial exposure and test presentation are in continuous speech. Electrophysiological evidence attests that this indeed occurs: An increased extended negativity (word recognition effect) appears for familiarized target words relative to control words. This response proved constant at the individual level: Only infants who showed this negativity at test had shown such a response, within six repetitions after first occurrence, during familiarization.

Abstract

Lateralization is an important aspect of the functional brain architecture for language and other cognitive faculties. The molecular genetic basis of human brain lateralization is unknown, and recent studies have suggested that gene expression in the cerebral cortex is bilaterally symmetrical. Here we have re-analyzed two transcriptomic datasets derived from post mortem human cerebral cortex, with a specific focus on superior temporal and auditory language cortex in adults. We applied an empirical Bayes approach to model differential left-right expression, together with gene ontology analysis and meta-analysis. There was robust and reproducible lateralization of individual genes and gene ontology groups that are likely to fine-tune the electrophysiological and neurotransmission properties of cortical circuits, most notably synaptic transmission, nervous system development and glutamate receptor activity. Our findings anchor the cerebral biology of language to the molecular genetic level. Future research in model systems may determine how these molecular signatures of neurophysiological lateralization effect fine-tuning of cerebral cortical function, differently in the two hemispheres.

Abstract

Second-language learners often experience major difficulties in producing non-native speech sounds. This paper introduces a training method that uses a real-time analysis of the acoustic properties of vowels produced by non-native speakers to provide them with immediate, trial-by-trial visual feedback about their articulation alongside that of the same vowels produced by native speakers. The Mahalanobis acoustic distance between non-native productions and target native acoustic spaces was used to assess L2 production accuracy. The experiment shows that 1 h of training per vowel improves the production of four non-native Danish vowels: the learners' productions were closer to the corresponding Danish target vowels after training. The production performance of a control group remained unchanged. Comparisons of pre- and post-training vowel discrimination performance in the experimental group showed improvements in perception. Correlational analyses of training-related changes in production and perception revealed no relationship. These results suggest, first, that this training method is effective in improving non-native vowel production. Second, training purely on production improves perception. Finally, it appears that improvements in production and perception do not systematically progress at equal rates within individuals. (C) 2015 Acoustical Society of America.

Abstract

The relocation of animals can induce stress when animals are placed in novel environmental conditions. The movement of captive animals among facilities is common, especially for non-human primates used in research. The stress response begins with the activation of the hypothalamic-pituitary-adrenal (HPA) axis which results in the release of glucocorticoid hormones (GC), which at chronic levels could lead to deleterious physiological effects. There is a substantial body of data concerning GC levels affecting reproduction, and rank and aggression in primates. However, the effect of transport has received much less attention. Fecal samples from eight (four male and four female) captive-bred cotton-top tamarins (Saguinus oedipus) were collected at four different time points (two pre-transport and two post-transport). The fecal samples were analyzed using an immunoassay to determine GC levels. A repeated measures analysis of variance (ANOVA) demonstrated that GC levels differed among transport times (p = 0.009), but not between sexes (p = 0.963). Five of the eight tamarins exhibited an increase in GC levels after transport. Seven of the eight tamarins exhibited a decrease in GC levels from three to six days post-transport to three weeks post-transport. Most values returned to pre-transport levels after three weeks. The results indicate that these tamarins experienced elevated GC levels following transport, but these increases were of short duration. This outcome would suggest that the negative effects of elevated GC levels were also of short duration.

Abstract

A comprehensive theory of language acquisition must explain how human infants can learn any one of the world’s 7000 or so languages. As such, an important part of understanding how languages are learned is to investigate acquisition across a range of diverse languages and sociocultural contexts. To this end, cross-linguistic and cross-cultural language research has been pervasive in the field of first language acquisition since the early 1980s. In groundbreaking work, Slobin (1985) noted that the study of acquisition in cross-linguistic perspective can be used to reveal both developmental universals and language-specific acquisition patterns. Since this observation there have been several waves of cross-linguistic first language acquisition research, and more recently we have seen a rise in research investigating lesser-known languages. This special issue brings together work on several such languages, spoken in minority contexts. It is the first collection of language development research dedicated to the acquisition of under-studied or little-known languages and by extension, different cultures. Why lesser-known languages, and why minority contexts? First and foremost, acquisition theories need data from different languages, language families and cultural groups across the broadest typological array possible, and yet many theories of acquisition have been developed through analyses of English and other major world languages. Thus they are likely to be skewed by sampling bias. Languages of European origin constitute a small percentage of the total number of languages spoken worldwide. The Ethnologue (2015) lists 7102 languages spoken across the world. Of these, only 286 languages are languages of European origin, a mere 4% of the total number of languages spoken across the planet, and representing approximately only 26% of the total number of language speakers alive today. Compare this to the languages of the Pacific. The Ethnologue lists 1313 languages spoken in the Pacific, constituting 18.5% of the world’s languages. Of these, very few have been described, and even fewer have child language data available. Lieven and Stoll (2010) note that only around 70–80 languages have been the focus of acquisition studies (around 1% of the world’s languages). This somewhat alarming statistic suggests that the time is now ripe for researchers working on lesser-known languages to contribute to the field’s knowledge about how children learn a range of very different languages across differing cultures, and in doing so, for this research to make a contribution to language acquisition theory. The potential benefits are many. First, decades of descriptive work in linguistic typology have culminated in strong challenges to the existence of a Universal Grammar (Evans & Levinson, 2009), a long-held axiom of formal language acquisition theory. To be sure, cross-linguistic work in acquisition has long fuelled this debate (e.g. MacWhinney & Bates, 1989), but only as we collect a greater number of data points will we move closer toward a better understanding of the initial state of the human capacity for language and the types of social and cultural contexts in which language is successfully transmitted. A focus on linguistic diversity enables the investigation and postulation of universals in language acquisition, if and in whatever form they exist. In doing so, we can determine the sorts of things that are evident in child-directed speech, in children’s language production and in adult language, teasing out the threads at the intersection of language, culture and cognition. The study and dissemination of research into lesser-known, under-described languages with small communities significantly contributes to this aim because it not only reflects the diversity of languages present in the world, but provides a better representation of the social and economic conditions under which the majority of the world’s population acquire language (Heinrich, Heins, & Norenzayan, 2010). Related to this point, the study of smaller languages has taken on intense urgency in the past few decades due to the rapid extinction of these languages (Evans, 2010). The Language Documentation movement has toiled tirelessly in the pursuit of documenting languages before they disappear, an effort to which child language researchers have much to offer. Many children acquire smaller and minority languages in rich multilingual environments, where the influence of dominant languages affects acquisition (e.g., Stoll, Zakharko, Moran, Schikowski, & Bickel, 2015). Understanding the acquisition process where systems compete and may be in flux due to language contact, while no small task, will help us understand the social and economic conditions which favour successful preservation of minority languages, which could ultimately equip communities with the tools to stem the flow of language loss. With these points in mind we now turn to the articles in this special issue.

Abstract

One of the major challenges in acquiring a language is being able to use morphology as an adult would, and thus, a considerable amount of acquisition research has focused on morphological production and comprehension. Most of this research, however, has focused on the acquisition of morphology in isolating languages, or languages (such as English) with limited inflectional morphology. The nature of the learning task is different, and potentially more challenging, when the child is learning a polysynthetic language – a language in which words are highly morphologically complex, expressing in a single word what in English takes a multi-word clause. To date, there has been no cross-linguistic survey of how children approach this puzzle and learn polysynthetic languages. This paper aims to provide such a survey, including a discussion of some of the general findings in the literature regarding the acquisition of polysynthetic systems

Abstract

Hand gestures and speech form a single integrated system of meaning during language comprehension, but is gesture processed with speech in a unique fashion? We had subjects watch multimodal videos that presented auditory (words) and visual (gestures and actions on objects) information. Half of the subjects related the audio information to a written prime presented before the video, and the other half related the visual information to the written prime. For half of the multimodal video stimuli, the audio and visual information contents were congruent, and for the other half, they were incongruent. For all subjects, stimuli in which the gestures and actions were incongruent with the speech produced more errors and longer response times than did stimuli that were congruent, but this effect was less prominent for speech-action stimuli than for speech-gesture stimuli. However, subjects focusing on visual targets were more accurate when processing actions than gestures. These results suggest that although actions may be easier to process than gestures, gestures may be more tightly tied to the processing of accompanying speech.

Abstract

We hypothesized that bone resorption acts to increase bone strength through stimulation of periosteal expansion. Hence, we examined whether bone resorption, as reflected by serum β-C-telopeptides of type I collagen (CTX), is positively associated with periosteal circumference (PC), in contrast to inverse associations with parameters related to bone remodeling such as cortical bone mineral density (BMDC ). CTX and mid-tibial peripheral quantitative computed tomography (pQCT) scans were available in 1130 adolescents (mean age 15.5 years) from the Avon Longitudinal Study of Parents and Children (ALSPAC). Analyses were adjusted for age, gender, time of sampling, tanner stage, lean mass, fat mass, and height. CTX was positively related to PC (β=0.19 [0.13, 0.24]) (coefficient=SD change per SD increase in CTX, 95% confidence interval)] but inversely associated with BMDC (β=-0.46 [-0.52,-0.40]) and cortical thickness [β=-0.11 (-0.18, -0.03)]. CTX was positively related to bone strength as reflected by the strength-strain index (SSI) (β=0.09 [0.03, 0.14]). To examine the causal nature of this relationship, we then analyzed whether single-nucleotide polymorphisms (SNPs) within key osteoclast regulatory genes, known to reduce areal/cortical BMD, conversely increase PC. Fifteen such genetic variants within or proximal to genes encoding receptor activator of NF-κB (RANK), RANK ligand (RANKL), and osteoprotegerin (OPG) were identified by literature search. Six of the 15 alleles that were inversely related to BMD were positively related to CTX (p<}0.05 cut-off) (n=2379). Subsequently, we performed a meta-analysis of associations between these SNPs and PC in ALSPAC (n=3382), Gothenburg Osteoporosis and Obesity Determinants (GOOD) (n=938), and the Young Finns Study (YFS) (n=1558). Five of the 15 alleles that were inversely related to BMD were positively related to PC (p{<0.05 cut-off). We conclude that despite having lower BMD, individuals with a genetic predisposition to higher bone resorption have greater bone size, suggesting that higher bone resorption is permissive for greater periosteal expansion.

Abstract

Heritability of bone mineral density (BMD) varies across skeletal sites, reflecting different relative contributions of genetic and environmental influences. To quantify the degree to which common genetic variants tag and environmental factors influence BMD, at different sites, we estimated the genetic (rg) and residual (re) correlations between BMD measured at the upper limbs (UL-BMD), lower limbs (LL-BMD) and skull (SK-BMD), using total-body DXA scans of ∼ 4,890 participants recruited by the Avon Longitudinal Study of Parents and their Children (ALSPAC). Point estimates of rg indicated that appendicular sites have a greater proportion of shared genetic architecture (LL-/UL-BMD rg = 0.78) between them, than with the skull (UL-/SK-BMD rg = 0.58 and LL-/SK-BMD rg = 0.43). Likewise, the residual correlation between BMD at appendicular sites (r(e) = 0.55) was higher than the residual correlation between SK-BMD and BMD at appendicular sites (r(e) = 0.20-0.24). To explore the basis for the observed differences in rg and re, genome-wide association meta-analyses were performed (n ∼ 9,395), combining data from ALSPAC and the Generation R Study identifying 15 independent signals from 13 loci associated at genome-wide significant level across different skeletal regions. Results suggested that previously identified BMD-associated variants may exert site-specific effects (i.e. differ in the strength of their association and magnitude of effect across different skeletal sites). In particular, variants at CPED1 exerted a larger influence on SK-BMD and UL-BMD when compared to LL-BMD (P = 2.01 × 10(-37)), whilst variants at WNT16 influenced UL-BMD to a greater degree when compared to SK- and LL-BMD (P = 2.31 × 10(-14)). In addition, we report a novel association between RIN3 (previously associated with Paget's disease) and LL-BMD (rs754388: β = 0.13, SE = 0.02, P = 1.4 × 10(-10)). Our results suggest that BMD at different skeletal sites is under a mixture of shared and specific genetic and environmental influences. Allowing for these differences by performing genome-wide association at different skeletal sites may help uncover new genetic influences on BMD.

Abstract

This paper presents a theory of the syntactic aspects of human sentence production. An important characteristic of unprepared speech is that overt pronunciation of a sentence can be initiated before the speaker has completely worked out the meaning content he or she is going to express in that sentence. Apparently, the speaker is able to build up a syntactically coherent utterance out of a series of syntactic fragments each rendering a new part of the meaning content. This incremental, left-to-right mode of sentence production is the central capability of the proposed Incremental Procedural Grammar (IPG). Certain other properties of spontaneous speech, as derivable from speech errors, hesitations, self-repairs, and language pathology, are accounted for as well. The psychological plausibility thus gained by the grammar appears compatible with a satisfactory level of linguistic plausibility in that sentences receive structural descriptions which are in line with current theories of grammar. More importantly, an explanation for the existence of configurational conditions on transformations and other linguistics rules is proposed. The basic design feature of IPG which gives rise to these psychologically and linguistically desirable properties, is the “Procedures + Stack” concept. Sentences are built not by a central constructing agency which overlooks the whole process but by a team of syntactic procedures (modules) which work-in parallel-on small parts of the sentence, have only a limited overview, and whose sole communication channel is a stock. IPG covers object complement constructions, interrogatives, and word order in main and subordinate clauses. It handles unbounded dependencies, cross-serial dependencies and coordination phenomena such as gapping and conjunction reduction. It is also capable of generating self-repairs and elliptical answers to questions. IPG has been implemented as an incremental Dutch sentence generator written in LISP.

Abstract

A new cognitive architecture is proposed for the syntactic aspects of human sentence processing. The architecture, called Unification Space, is biologically inspired but not based on neural nets. Instead it relies on biosynthesis as a basic metaphor. We use simulated annealing as an optimization technique which searches for the best configuration of isolated syntactic segments or subtrees in the final parse tree. The gradually decaying activation of individual syntactic nodes determines the ‘global excitation level’ of the system. This parameter serves the function of ‘computational temperature’ in simulated annealing. We have built a computer implementation of the architecture which simulates well-known sentence understanding phenomena. We report successful simulations of the psycholinguistic effects of clause embedding, minimal attachment, right association and lexical ambiguity. In addition, we simulated impaired sentence understanding as observable in agrammatic patients. Since the Unification Space allows for contextual (semantic and pragmatic) influences on the syntactic tree formation process, it belongs to the class of interactive sentence processing models.

Abstract

The study develops a neurocomputational architecture for grammatical processing in language production and language comprehension (grammatical encoding and decoding, respectively). It seeks to answer two questions. First, how is online syntactic structure formation of the complexity required by natural-language grammars possible in a fixed, preexisting neural network without the need for online creation of new connections or associations? Second, is it realistic to assume that the seemingly disparate instantiations of syntactic structure formation in grammatical encoding and grammatical decoding can run on the same neural infrastructure? This issue is prompted by accumulating experimental evidence for the hypothesis that the mechanisms for grammatical decoding overlap with those for grammatical encoding to a considerable extent, thus inviting the hypothesis of a single “grammatical coder.” The paper answers both questions by providing the blueprint for a syntactic structure formation mechanism that is entirely based on prewired circuitry (except for referential processing, which relies on the rapid learning capacity of the hippocampal complex), and can subserve decoding as well as encoding tasks. The model builds on the “Unification Space” model of syntactic parsing developed by Vosse & Kempen (2000, 2008, 2009). The design includes a neurocomputational mechanism for the treatment of an important class of grammatical movement phenomena.

Abstract

A series of experiments is reported in which subjects describe simple visual scenes by means of both sentential and non-sentential responses. The data support the following statements about the lexicalization (word finding) process. (1) Words used by speakers in overt naming or sentence production responses are selected by a sequence of two lexical retrieval processes, the first yielding abstract pre-phonological items (Ll -items), the second one adding their phonological shapes (L2-items). (2) The selection of several Ll-items for a multi-word utterance can take place simultaneously. (3) A monitoring process is watching the output of Ll-lexicalization to check if it is in keeping with prevailing constraints upon utterance format. (4) Retrieval of the L2-item which corresponds with a given LI-item waits until the Ld-item has been checked by the monitor, and all other Ll-items needed for the utterance under construction have become available. A coherent picture of the lexicalization process begins to emerge when these characteristics are brought together with other empirical results in the area of naming and sentence production, e.g., picture naming reaction times (Seymour, 1979), speech errors (Garrett, 1980), and word order preferences (Bock, 1982).

Abstract

Previous work has shown that Dutch listeners use prosodic information in the speech signal to optimise morphological processing: Listeners are sensitive to prosodic differences between a noun stem realised in isolation and a noun stem realised as part of a plural form (in which the stem is followed by an unstressed syllable). The present study, employing a lexical decision task, provides an additional demonstration of listeners' sensitivity to prosodic cues in the stem. This sensitivity is shown for two languages that differ in morphological productivity: Dutch and English. The degree of morphological productivity does not correlate with listeners' sensitivity to prosodic cues in the stem, but it is reflected in differential sensitivities to the word-specific log odds ratio of encountering an unshortened stem (i.e., a stem in isolation) versus encountering a shortened stem (i.e., a stem followed by a suffix consisting of one or more unstressed syllables). In addition to being sensitive to the prosodic cues themselves, listeners are also sensitive to the probabilities of occurrence of these prosodic cues.

Abstract

It has recently been shown that listeners use systematic differences in vowel length and intonation to resolve ambiguities between onset-matched simple words (Davis, Marslen-Wilson, & Gaskell, 2002; Salverda, Dahan, & McQueen, 2003). The present study shows that listeners also use prosodic information in the speech signal to optimize morphological processing. The precise acoustic realization of the stem provides crucial information to the listener about the morphological context in which the stem appears and attenuates the competition between stored inflectional variants. We argue that listeners are able to make use of prosodic information, even though the speech signal is highly variable within and between speakers, by virtue of the relative invariance of the duration of the onset. This provides listeners with a baseline against which the durational cues in a vowel and a coda can be evaluated. Furthermore, our experiments provide evidence for item-specific prosodic effects.

Abstract

The practices of other-initiation of repair provide speakers with a set of solutions to one of the most basic problems in conversation: troubles of speaking, hearing, and understanding. Based on a collection of 227 cases systematically identified in a corpus of English conversation, this article describes the formats and practices of other-initiations of repair attested in the corpus and reports their quantitative distribution. In addition to straight other-initiations of repair, the identification of all possible cases also yielded a substantial proportion in which speakers use other-initiations to perform other actions, including non-serious actions, such as jokes and teases, preliminaries to dispreferred responses, and displays of surprise and disbelief. A distinction is made between other-initiations that perform additional actions concurrently and those that formally resemble straight other-initiations but analyzably do not initiate repair as an action.

Abstract

The transitions between turns at talk in conversation tend to occur quickly, with only a slight gap of approximately 100 to 300 ms between them. This estimate of central tendency, however, hides a wealth of complex variation, as a number of factors, such as the type of turns involved, have been shown to influence the timing of turn transitions. This article considers one specific type of turn that does not conform to the statistical trend, namely turns that deal with troubles of speaking, hearing, and understanding, known as other-initiations of repair. The results of a quantitative analysis of 169 other-initiations of repair in face-to-face conversation reveal that the most frequent cases occur after gaps of approximately 700 ms. Furthermore, other-initiations of repair that locate a source of trouble in a prior turn specifically tend to occur after shorter gaps than those that do not, and those that correct errors in a prior turn, while rare, tend to occur without delay. An analysis of the transitions before other-initiations of repair, using methods of conversation analysis, suggests that speakers use the extra time (i) to search for a late recognition of the problematic turn, (ii) to provide an opportunity for the speaker of the problematic turn to resolve the trouble independently, (iii) and to produce visual signals, such as facial gestures. In light of these results, it is argued that other-initiations of repair take priority over other turns at talk in conversation and therefore are not subject to the same rules and constraints that motivate fast turn transitions in general

Abstract

Conversation-analytic research has argued that the timing and construction of preferred responding actions (e.g., acceptances) differ from that of dispreferred responding actions (e.g., rejections), potentially enabling early response prediction by recipients. We examined 195 preferred and dispreferred responding actions in telephone corpora and found that the timing of the most frequent cases of each type did not differ systematically. Only for turn transitions of 700 ms or more was the proportion of dispreferred responding actions clearly greater than that of preferreds. In contrast, an analysis of the timing that included turn formats (i.e., those with or without qualification) revealed clearer differences. Small departures from a normal gap duration decrease the likelihood of a preferred action in a preferred turn format (e.g., a simple “yes”). We propose that the timing of a response is best understood as a turn-constructional feature, the first virtual component of a preferred or dispreferred turn format.

Abstract

For real-time and embedded systems, limiting the consumption of time and memory resources is often an important part of the requirements. Being able to predict bounds on the consumption of such resources during the development process of the code can be of great value. In this paper, we focus mainly on memory-related bounds. Recent research results have advanced the state of the art of resource consumption analysis. In this paper, we present a toolset that makes it possible to apply these research results in practice for (real-time) systems enabling JAVA developers to analyse symbolic loop bounds, symbolic bounds on heap size and both symbolic and numeric bounds on stack size. We describe which theoretical additions were needed in order to achieve this. We give an overview of the capabilities of the RESANA (Radboud University Nijmegen, The Netherlands) toolset that is the result of this effort. The toolset can not only perform generally applicable analyses, but it also contains a part of the analysis that is dedicated to the developers' (real-time) virtual machine, such that the results apply directly to the actual development environment that is used in practice

Abstract

In Dutch, high-frequency words with the suffix -lijk are often highly reduced in spontaneous unscripted speech. This study addressed socio-geographic variation in the reduction of such words against the backdrop of the variation in their use in written and spoken Dutch. Multivariate analyses of the frequencies with which the words were used in a factorially contrasted set of subcorpora revealed signi ficant variation involving the speaker's country, sex, and education level for spoken Dutch, and involving country and register for written Dutch. Acoustic analyses revealed that Dutch men reduced most often, while Flemish highly educated women reduced least. Two linguistic context effects emerged, one prosodic, and the other pertaining to the flow of information. Words in sentence final position showed less reduction, while words that were better predictable from the preceding word in the sentence(based on mutual information) tended to be reduced more often. The increased probability of reduction for forms that are more predictable in context, combined with the loss of the suffix in the more extremely reduced forms, suggests that highfrequency words in -lijk are undergoing a process of erosion that causes them to gravitate towards monomorphemic function words.

Abstract

The current study investigated the role of cross-linguistic influence in Cantonese–English bilingual children's comprehension of subject- and object-extracted relative clauses (RCs). Twenty simultaneous Cantonese–English bilingual children (Mage = 8;11, SD = 2;6) and 20 vocabulary-matched Cantonese monolingual children (Mage = 6;4, SD = 1;3) completed a test of Cantonese RC comprehension. The bilingual children also completed a test of English RC comprehension. The results showed that, whereas the monolingual children were equally competent on subject and object RCs, the bilingual children performed significantly better on subject RCs. Error analyses suggested that the bilingual children were most often correctly assigning thematic roles in object RCs, but were incorrectly choosing the RC subject as the head referent. This pervasive error was interpreted to be due to the fact that both Cantonese and English have canonical SVO word order, which creates competition with structures that compete with an object RC analysis.

Abstract

This paper reports on an investigation of children's (aged 3;5–9;8) comprehension of sentences containing ambiguity of prepositional phrase (PP) attachment. Results from a picture selection study (N=90) showed that children use verb semantics and preposition type to resolve the ambiguity, with older children also showing sensitivity to the definiteness of the object NP as a cue to interpretation. Study 2 investigated three- and five-year-old children's (N=47) ability to override an instrumental interpretation of ambiguous PPs in order to process attributes of the referential scene. The results showed that while five-year-olds are capable of incorporating aspects of the referential scene into their interpretations, three-year-olds are not as successful. Overall, the results suggest that children are attuned very early to the lexico-semantic co-occurrences that have been shown to aid ambiguity resolution in adults, but that more diffuse cues to interpretation are used only later in development

Abstract

Although there is strong evidence for shared abstract grammatical structure in bilingual speakers from studies of sentence production, comparable evidence from studies of comprehension is lacking. Twenty-seven (N = 27) English-German bilingual adults participated in a structural priming study where unambiguous English subject and object relative clause (RC) structures were used to prime corresponding subject and object RC interpretations of structurally ambiguous German RCs. The results showed that English object RCs primed significantly greater object RC interpretations in German in comparison to baseline and subject RC prime conditions, but that English subject RC primes did not change the participants’ baseline preferences. This is the first study to report abstract crosslinguistic priming in comprehension. The results specifically suggest that word order overlap supports the integration of syntactic structures from different languages in bilingual speakers, and that these shared representations are used in comprehension as well as production

Abstract

Since Battison (1978), it has been noted in many signed languages that the Symmetry Condition constrains the form of two-handed signs in which two hands move independently. The Condition states that the form features (e.g., the handshapes and movements) of the two hands are 'symmetrical'. The Symmetry Condition has been regarded in the literature as a part of signed language phonology. In this study, we examine the linguistic status of the Symmetry Condition by comparing the degree of symmetry in signs from Sign Language of the Netherlands and speech-accompanying representational gestures produced by Dutch speakers. Like signed language, such gestures use hand movements to express concepts, but they do not constitute a linguistic system in their own right. We found that the Symmetry Condition holds equally well for signs and spontaneous gestures. This indicates that this condition is a general cognitive constraint, rather than a constraint specific to language. We suggest that the Symmetry Condition is a manifestation of the mind having one active 'mental articulator' when expressing a concept with hand movements

Abstract

Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neuropsychiatric disorder with a complex genetic background. The G protein-coupled receptor kinase interacting ArfGAP 1 (GIT1) gene was previously associated with ADHD. We aimed at replicating the association of GIT1 with ADHD and investigated its role in cognitive and brain phenotypes. Gene-wide and single variant association analyses for GIT1 were performed for three cohorts: (1) the ADHD meta-analysis data set of the Psychiatric Genomics Consortium (PGC, N=19,210), (2) the Dutch cohort of the International Multicentre persistent ADHD CollaboraTion (IMpACT-NL, N=225), and (3) the Brain Imaging Genetics cohort (BIG, N=1,300). Furthermore, functionality of the rs550818 variant as an expression quantitative trait locus (eQTL) for GIT1 was assessed in human blood samples. By using Drosophila melanogaster as a biological model system, we manipulated Git expression according to the outcome of the expression result and studied the effect of Git knockdown on neuronal morphology and locomotor activity. Association of rs550818 with ADHD was not confirmed, nor did a combination of variants in GIT1 show association with ADHD or any related measures in either of the investigated cohorts. However, the rs550818 risk-genotype did reduce GIT1 expression level. Git knockdown in Drosophila caused abnormal synapse and dendrite morphology, but did not affect locomotor activity. In summary, we could not confirm GIT1 as an ADHD candidate gene, while rs550818 was found to be an eQTL for GIT1. Despite GIT1's regulation of neuronal morphology, alterations in gene expression do not appear to have ADHD-related behavioral consequences

Abstract

Tense is traditionally assumed to express temporal relations between the time of the event and the moment of speech, whereas aspect expresses various views on one and the same event. In Klein (1994), it was argued that the intuitions which underlie this viewing metaphor can be made precise by a time-relational analysis as well. In his article “Aspect vs. relative tense: the case reopened”, Jürgen Bohnemeyer challenges one important point of this analysis, the equation of aspect and relative tense in the English perfect and in temporal forms of few other languages. In the present comment, it is argued that this is indeed a simplification, which does not speak, however, against a time-relational analysis of aspect in general. The main lines of such an analysis for the English perfect are sketched. It is shown that it naturally accounts for differences between the simple past and the present perfect, as well as for the oddity of constructions such as Einstein has visited Princeton or Ira has left yesterday at five.

Abstract

The vocal development of cranes (Gruidae) has attracted scientific interest due to a
special stage, so-called voice breaking. During voice breaking, chicks produce both
adult low-frequency and juvenile high-frequency vocalizations. The triggers that affect voice breaking are unknown. For the first time, we study the vocal development of the Demoiselle Crane (Anthropoides virgo). We describe the age and possible drivers of
the onset of voice breaking. We analyse the calls of 21 Demoiselle Crane chicks, and
compare them with the calls of six adult birds, noting the day when adult low-frequency calls are first recorded as the day when voice breaking begins. The age of voice
breaking onset does not depend on hatching date, clutch order or chick body mass. Thus, there is no correlation between body growth and the onset of voice breaking for individual Demoiselle Crane chicks. However, there is a strong relationship between body mass and voice breaking among different crane species. Demoiselle Cranes stop intense body growth at the age of 2 months and start voice breaking at 70 ^ 46 days. By way of comparison, Red-crowned Cranes finish the period of intense body growth at the age of 7 months and start voice breaking at 211 ^ 60 days. Thus, we show that the Demoiselle Crane has a sudden vocal development, similar to other crane species, and we suggest that the end of intense body growth is the trigger for the onset of voice breaking in cranes.

Abstract

The direction of object enumeration reflects children’s enculturation but previous work on the development of such spatial preferences has been inconsistent. Therefore, we documented directional preferences in finger counting, object counting, and picture naming for children (4 groups from 3 to 6 years, N = 104) and adults (N = 56). We found a right-side preference for finger counting in 3- to 6-year-olds and a left-side preference for counting objects and naming pictures by 6 years of age. Children were consistent in their special preferences when comparing object counting and picture naming, but not in other task pairings. Finally, spatial preferences were not related to cardinality comprehension. These results, together with other recent work, suggest a gradual development of spatial-numerical associations from early non-directional mappings into culturally constrained directional mappings.

Abstract

Recent studies indicate that Arabic digit knowledge rather than non-symbolic number knowledge is a key foundation for arithmetic proficiency at the start of a child’s mathematical career. We document the developmental trajectory of 4- to 7-year-olds’ proficiency in accessing magnitude information from Arabic digits in five tasks differing in magnitude manipulation requirements. Results showed that children from 5 years onwards accessed magnitude information implicitly and explicitly, but that 5-year-olds failed to access magnitude information explicitly when numerical magnitude was contrasted with physical magnitude. Performance across tasks revealed a clear developmental trajectory: children traverse from first knowing the cardinal values of number words to recognizing Arabic digits to knowing their cardinal values and, concurrently, their ordinal position. Correlational analyses showed a strong within-child consistency, demonstrating that this pattern is not only reflected in group differences but also in individual performance.

Abstract

Diffusion-weighted Magnetic Resonance Imaging (DW-MRI) has emerged as the most popular neuroimaging technique used to depict the biological microstructural properties of human brain white matter. However, like other MRI techniques, traditional DW-MRI data remains subject to head motion artifacts during scanning. For example, previous studies have indicated that, with traditional DW-MRI data, head motion artifacts significantly affect the evaluation of diffusion metrics. Actually, DW-MRI data scanned with higher sampling rate are important for accurately evaluating diffusion metrics because it allows for full-brain coverage through the acquisition of multiple slices simultaneously and more gradient directions. Here, we employed a publicly available multiband DW-MRI dataset to investigate the association between motion and diffusion metrics with the standard pipeline, tract-based spatial statistics (TBSS). The diffusion metrics used in this study included not only the commonly used metrics (i.e., FA and MD) in DW-MRI studies, but also newly proposed inter-voxel metric, local diffusion homogeneity (LDH). We found that the motion effects in FA and MD seems to be mitigated to some extent, but the effect on MD still exists. Furthermore, the effect in LDH is much more pronounced. These results indicate that researchers shall be cautious when conducting data analysis and interpretation. Finally, the motion-diffusion association is discussed.

Abstract

Magnetic resonance imaging (MRI) provides valuable data for understanding the human mind and brain disorders, but in-scanner head motion introduces systematic and spurious biases. For example, differences in MRI measures (e.g., network strength, white matter integrity) between patient and control groups may be due to the differences in their head motion. To determine whether head motion is an important variable in itself, or just simply a confounding variable, we explored individual differences in psychological traits that may predispose some people to move more than others during an MRI scan. In the first two studies, we demonstrated in both children (N  =  245) and adults (N  =  581) that head motion, estimated from resting-state functional MRI and diffusion tensor imaging, was reliably correlated with impulsivity scores. Further, the difference in head motion between children with attention deficit hyperactivity disorder (ADHD) and typically developing children was largely due to differences in impulsivity. Finally, in the third study, we confirmed the observation that the regression approach, which aims to deal with motion issues by regressing out motion in the group analysis, would underestimate the effect of interest. Taken together, the present findings provide empirical evidence that links in-scanner head motion to psychological traits.

Abstract

Representing brain morphology as a network has the advantage that the regional morphology of ‘isolated’ structures can be described statistically based on graph theory. However, very few studies have investigated brain morphology from the holistic perspective of complex networks, particularly in individual brains. We proposed a new network framework for individual brain morphology. Technically, in the new network, nodes are defined as regions based on a brain atlas, and edges are estimated using our newly-developed inter-regional relation measure based on regional morphological distributions. This implementation allows nodes in the brain network to be functionally/anatomically homogeneous but different with respect to shape and size. We first demonstrated the new network framework in a healthy sample. Thereafter, we studied the graph-theoretical properties of the networks obtained and compared the results with previous morphological, anatomical, and functional networks. The robustness of the method was assessed via measurement of the reliability of the network metrics using a test-retest dataset. Finally, to illustrate potential applications, the networks were used to measure age-related changes in commonly used network metrics. Results suggest that the proposed method could provide a concise description of brain organization at a network level and be used to investigate interindividual variability in brain morphology from the perspective of complex networks. Furthermore, the method could open a new window into modeling the complexly distributed brain and facilitate the emerging field of human connectomics.

Abstract

Background Although local features of brain morphology have been widely investigated in neuroscience, the inter-regional relations in brain morphology have rarely been investigated, especially not for individual participants. New method In this paper, we proposed a novel framework for investigating this relation based on an individual's magnetic resonance imaging (MRI) data. The key idea was to estimate the probability density function (PDF) of local morphological features within a brain region to provide a global description of this region. Then, the inter-regional relations were quantified by calculating the similarity of the PDFs for pairs of regions based on the Kullback–Leibler (KL) divergence. Results For illustration, we applied this approach to a pre-post intervention study to investigate the longitudinal changes in morphological relations after long-term sleep deprivation. The results suggest the potential application of this new method for studies on individual differences in brain structure. Comparison with existing methods The current method can be employed to estimate individual morphological relations between regions, which have been largely ignored by previous studies. Conclusions Our morphological relation metric, as a novel quantitative biomarker, can be used to investigate normal individual variability and even within-individual alterations/abnormalities in brain structure.

Abstract

Sentence production requires mapping preverbal messages onto linguistic structures. Because sentences are normally built incrementally, the information encoded in a sentence-initial increment is critical for explaining how the mapping process starts and for predicting its timecourse. Two experiments tested whether and when speakers prioritize encoding of different types of information at the outset of formulation by comparing production of descriptions of transitive events (e.g., A dog is chasing the mailman) that differed on two dimensions: the ease of naming individual characters and the ease of apprehending the event gist (i.e., encoding the relational structure of the event). To additionally manipulate ease of encoding, speakers described the target events after receiving lexical primes (facilitating naming; Experiment 1) or structural primes (facilitating generation of a linguistic structure; Experiment 2). Both properties of the pictured events and both types of primes influenced the form of target descriptions and the timecourse of formulation: character-specific variables increased the probability of speakers encoding one character with priority at the outset of formulation, while the ease of encoding event gist and of generating a syntactic structure increased the likelihood of early encoding of information about both characters. The results show that formulation is flexible and highlight some of the conditions under which speakers might employ different planning strategies.

Abstract

Children begin to talk at about age one. The vocabulary they need to do so must be built on perceptual evidence and, indeed, infants begin to recognize spoken words long before they talk. Most of the utterances infants hear, however, are continuous, without pauses between words, so constructing a vocabulary requires them to decompose continuous speech in order to extract the individual words. Here, we present electrophysiological evidence that 10-month-old infants recognize two-syllable words they have previously heard only in isolation when these words are presented anew in continuous speech. Moreover, they only need roughly the first syllable of the word to begin doing this. Thus, prelinguistic infants command a highly efficient procedure for segmentation and recognition of spoken words in the absence of an existing vocabulary, allowing them to tackle effectively the problem of bootstrapping a lexicon out of the highly variable, continuous speech signals in their environment.

Abstract

ime perception is a critical component of conscious experience. To be in synchrony with the environment, the brain must deal not only with differences in the speed of light and sound but also with its computational and neural transmission delays. Here, we asked whether the brain could actively compensate for temporal delays by changing its processing time. Specifically, can changes in neural timing or in the phase of neural oscillation index perceived timing? For this, a lag-adaptation paradigm was used to manipulate participants' perceived audiovisual (AV) simultaneity of events while they were recorded with magnetoencephalography (MEG). Desynchronized AV stimuli were presented rhythmically to elicit a robust 1 Hz frequency-tagging of auditory and visual cortical responses. As participants' perception of AV simultaneity shifted, systematic changes in the phase of entrained neural oscillations were observed. This suggests that neural entrainment is not a passive response and that the entrained neural oscillation shifts in time. Crucially, our results indicate that shifts in neural timing in auditory cortices linearly map participants' perceived AV simultaneity. To our knowledge, these results provide the first mechanistic evidence for active neural compensation in the encoding of sensory event timing in support of the emergence of time awareness.

Abstract

Objective Recently, de novo SCN8A missense mutations have been identified as a rare dominant cause of epileptic encephalopathies. Functional studies on the first described case demonstrated gain-of-function effects of the mutation. We describe a novel de novo mutation of SCN8A in a patient with epileptic encephalopathy, and functional characterization of the mutant protein. Design Whole exome sequencing was used to discover the variant. We generated a mutant cDNA, transfected HEK293 cells, and performed Western blotting to assess protein stability. To study channel functional properties, patch-clamp experiments were carried out in transfected neuronal ND7/23 cells. Results The proband exhibited seizure onset at 6 months of age, diffuse brain atrophy, and more profound developmental impairment than the original case. The mutation p.Arg233Gly in the voltage sensing transmembrane segment D1S4 was present in the proband and absent in both parents. This mutation results in a temperature-sensitive reduction in protein expression as well as reduced sodium current amplitude and density and a relative increased response to a slow ramp stimulus, though this did not result in an absolute increased current at physiological temperatures. Conclusion The new de novo SCN8A mutation is clearly deleterious, resulting in an unstable protein with reduced channel activity. This differs from the gain-of-function attributes of the first SCN8A mutation in epileptic encephalopathy, pointing to heterogeneity of mechanisms. Since Nav1.6 is expressed in both excitatory and inhibitory neurons, a differential effect of a loss-of-function of Nav1.6 Arg223Gly on inhibitory interneurons may underlie the epilepsy phenotype in this patient.

Abstract

Instrumental music and language are both syntactic systems, employing complex, hierarchically-structured sequences built using implicit structural norms. This organization allows listeners to understand the role of individual words or tones in the context of an unfolding sentence or melody. Previous studies suggest that the brain mechanisms of syntactic processing may be partly shared between music and language. However, functional neuroimaging evidence for anatomical overlap of brain activity involved in linguistic and musical syntactic processing has been lacking. In the present study we used functional magnetic resonance imaging (fMRI) in conjunction with an interference paradigm based on sung sentences. We show that the processing demands of musical syntax (harmony) and language syntax interact in Broca’s area in the left inferior frontal gyrus (without leading to music and language main effects). A language main effect in Broca’s area only emerged in the complex music harmony condition, suggesting that (with our stimuli and tasks) a language effect only becomes visible under conditions of increased demands on shared neural resources. In contrast to previous studies, our design allows us to rule out that the observed neural interaction is due to: (1) general attention mechanisms, as a psychoacoustic auditory anomaly behaved unlike the harmonic manipulation, (2) error processing, as the language and the music stimuli contained no structural errors. The current results thus suggest that two different cognitive domains—music and language—might draw on the same high level syntactic integration resources in Broca’s area.

Abstract

Developmental dyslexia is often characterized by a dual deficit in both word recognition accuracy and general processing speed. While previous research into dyslexic word recognition may have suffered from speed-accuracy trade-off, the present study employed a novel eye-tracking task that is less prone to such confounds. Participants (10 dyslexics and 12 controls) were asked to look at real word stimuli, and to ignore simultaneously presented non-word stimuli, while their eye-movements were recorded. Improvements in word recognition accuracy over time were modeled in terms of a continuous non-linear function. The words' rhyme consistency and the non-words' lexicality (unpronounceable, pronounceable, pseudohomophone) were manipulated within-subjects. Speed-related measures derived from the model fits confirmed generally slower processing in dyslexics, and showed a rhyme consistency effect in both dyslexics and controls. In terms of overall error rate, dyslexics (but not controls) performed less accurately on rhyme-inconsistent words, suggesting a representational deficit for such words in dyslexics. Interestingly, neither group showed a pseudohomophone effect in speed or accuracy, which might call the task-independent pervasiveness of this effect into question. The present results illustrate the importance of distinguishing between speed- vs. accuracy-related effects for our understanding of dyslexic word recognition

Abstract

This study investigates the adult grammars of French simultaneous bilingual speakers (2L1s) whose other language is German. Apart from providing an example of French as heritage language in Europe, the goals of this paper are (i) to compare the acquisition of French in a minority and majority language context, (ii) to identify the relative vulnerability of individual domains, and (iii) to investigate whether 2L1s are vulnerable to language attrition when moving to their heritage country during adulthood. We include two groups of German-French 2L1s: One group grew up predominantly in France, but moved to Germany during adulthood; the other group grew up predominantly in Germany and stayed there. Performance is compared in different domains, including adjective placement, gender marking, articles, prepositions, foreign accent and voice onset time. Results indicate that differences between the two groups are minimal in morpho-syntax, but more prominent in pronunciation.

Abstract

We review a number of recent studies that have identified either correlations between different linguistic features (e.g., implicational universals) or correlations between linguistic features and nonlinguistic properties of speakers or their environment (e.g., effects of geography on vocabulary). We compare large-scale quantitative studies with more traditional theoretical and historical linguistic research and identify divergent assumptions and methods that have led linguists to be skeptical of correlational work. We also attempt to demystify statistical techniques and point out the importance of informed critiques of the validity of statistical approaches. Finally, we describe various methods used in recent correlational studies to deal with the fact that, because of contact and historical relatedness, individual languages in a sample rarely represent independent data points, and we show how these methods may allow us to explore linguistic prehistory to a greater time depth than is possible with orthodox comparative reconstruction.

Abstract

In spontaneous conversations between adults, words are often pronounced with fewer segments or syllables than their citation forms. The question arises whether infant-directed speech also contains phonetic reduction. If so, infants would be presented with speech input that enables them to acquire reduced variants from an early age. This study compared speech directed at 11- and 12-month-old infants with adult-directed conversational speech and adult-directed read speech. In an acoustic study, 216 tokens of the Dutch words allemaal and helemaal from speech corpora were analyzed for duration, number of syllables, and vowel quality. In a perception study, adult participants rated these same materials for reduction and provided phonetic transcriptions. The results show that these two words are frequently reduced in infant-directed speech, and that their degree of reduction is comparable with conversational adult-directed speech. These findings suggest that lexical representations for reduced pronunciation variants can be acquired early in linguistic development

Abstract

The role of the two hemispheres in processing metaphoric language is controversial. While some studies have reported a special role of the right hemisphere (RH) in processing metaphors, others indicate no difference in laterality relative to literal language. Some studies have found a role of the RH for novel/unfamiliar metaphors, but not
conventional/familiar metaphors. It is not clear, however, whether the role of the RH
is specific to metaphor novelty, or whether it reflects processing, reinterpretation or
reanalysis of novel/unfamiliar language in general. Here we used functional magnetic
resonance imaging (fMRI) to examine the effects of familiarity in both metaphoric and
non-metaphoric sentences. A left lateralized network containing the middle and inferior
frontal gyri, posterior temporal regions in the left hemisphere (LH), and inferior frontal
regions in the RH, was engaged across both metaphoric and non-metaphoric sentences;
engagement of this network decreased as familiarity decreased. No region was engaged
selectively for greater metaphoric unfamiliarity. An analysis of laterality, however, showed that the contribution of the RH relative to that of LH does increase in a metaphorspecific manner as familiarity decreases. These results show that RH regions, taken by themselves, including commonly reported regions such as the right inferior frontal gyrus (IFG), are responsive to increased cognitive demands of processing unfamiliar stimuli, rather than being metaphor-selective. The division of labor between the two hemispheres, however, does shift towards the right for metaphoric processing. The shift results not because the RH contributes more to metaphoric processing. Rather, relative to
its contribution for processing literals, the LH contributes less.

Abstract

This study investigated the brain regions for the comprehension of implied emotion in sentences. Participants read negative sentences without negative words, for example, “The boy fell asleep and never woke up again,” and their neutral counterparts “The boy stood up and grabbed his bag.” This kind of negative sentence allows us to examine implied emotion derived at the sentence level, without associative emotion coming from word retrieval. We found that implied emotion in sentences, relative to neutral sentences, led to activation in some emotion-related areas, including the medial prefrontal cortex, the amygdala, and the insula, as well as certain language-related areas, including the inferior frontal gyrus, which has been implicated in combinatorial processing. These results suggest that the emotional network involved in implied emotion is intricately related to the network for combinatorial processing in language, supporting the view that sentence meaning is more than simply concatenating the meanings of its lexical building blocks.

Abstract

When speakers describe motion events using different languages, they subsequently classify those events in language-specific ways (Gennari, Sloman, Malt & Fitch, 2002). Here we ask if bilingual speakers flexibly shift their event classification preferences based on the language in which they verbally encode those events. English–Spanish bilinguals and monolingual controls described motion events in either Spanish or English. Subsequently they judged the similarity of the motion events in a triad task. Bilinguals tested in Spanish and Spanish monolinguals were more likely to make similarity judgments based on the path of motion versus bilinguals tested in English and English monolinguals. The effect is modulated in bilinguals by the age of acquisition of the second language. Late bilinguals based their judgments on path more often when Spanish was used to describe the motion events versus English. Early bilinguals had a path preference independent of the language in use. These findings support “thinking-for-speaking” (Slobin, 1996) in late bilinguals.

Abstract

Embodied theories of language postulate that language meaning is stored in modality-specific brain areas generally involved in perception and action in the real world. However, the temporal dynamics of the interaction between modality-specific information and lexical-semantic processing remain unclear. We investigated the relative timing at which two types of modality-specific information (action-based and visual-form information) contribute to lexical-semantic comprehension. To this end, we applied a behavioral priming paradigm in which prime and target words were related with respect to (1) action features, (2) visual features, or (3) semantically associative information. Using a Go/No-Go lexical decision task, priming effects were measured across four different inter-stimulus intervals (ISI = 100, 250, 400, and 1000 ms) to determine the relative time course of the different features. Notably, action priming effects were found in ISIs of 100, 250, and 1000 ms whereas a visual priming effect was seen only in the ISI of 1000 ms. Importantly, our data suggest that features follow different time courses of activation during word recognition. In this regard, feature activation is dynamic, measurable in specific time windows but not in others. Thus the current study (1) demonstrates how multiple ISIs can be used within an experiment to help chart the time course of feature activation and (2) provides new evidence for embodied theories of language.

Abstract

The chronic fatigue syndrome (CFS) is a disabling disorder of unknown etiology. The symptomatology of CFS (central fatigue, impaired concentration, attention and memory) suggests that this disorder could be related to alterations at the level of the central nervous system. In this study, we have used an automated and unbiased morphometric technique to test whether CFS patients display structural cerebral abnormalities. We mapped structural cerebral morphology and volume in two cohorts of CFS patients (in total 28 patients) and healthy controls (in total 28 controls) from high-resolution structural magnetic resonance images, using voxel-based morphometry. Additionally, we recorded physical activity levels to explore the relation between severity of CFS symptoms and cerebral abnormalities. We observed significant reductions in global gray matter volume in both cohorts of CFS patients, as compared to matched control participants. Moreover, the decline in gray matter volume was linked to the reduction in physical activity, a core aspect of CFS. These findings suggest that the central nervous system plays a key role in the pathophysiology of CFS and point to a new objective and quantitative tool for clinical diagnosis of this disabling disorder.

Abstract

We have used implicit motor imagery to investigate the neural correlates of motor planning independently from actual movements. Subjects were presented with drawings of left or right hands and asked to judge the hand laterality, regardless of the stimulus rotation from its upright orientation. We paired this task with a visual imagery control task, in which subjects were presented with typographical characters and asked to report whether they saw a canonical letter or its mirror image, regardless of its rotation. We measured neurovascular activity with fast event-related fMRI, distinguishing responses parametrically related to motor imagery from responses evoked by visual imagery and other task-related phenomena. By quantifying behavioral and neurovascular correlates of imagery on a trial-by-trial basis, we could discriminate between stimulusrelated, mental rotation-related, and response-related neural activity. We found that specific portions of the posterior parietal and precentral cortex increased their activity as a function of mental rotation only during the motor imagery task. Within these regions, the parietal cortex was visually responsive, whereas the dorsal precentral cortex was not. Response- but not rotation-related activity was found around the left central sulcus (putative primary motor cortex) during both imagery tasks. Our study provides novel evidence on the topography and content of movement representations in the human brain. During intended action, the posterior parietal cortex combines somatosensory and visuomotor information, whereas the dorsal premotor cortex generates the actual motor plan, and the primary motor cortex deals with movement execution. We discuss the relevance of these results in the context of current models of action planning.

Abstract

This study investigated processing of emotion words in autism spectrum disorders (ASD) using reaction times and event-related potentials (ERP). Adults with (n = 21) and without (n = 20) ASD performed a lexical decision task on emotion and neutral words while their brain activity was recorded. Both groups showed faster responses to emotion words compared to neutral, suggesting intact early processing of emotion in ASD. In the ERPs, the control group showed a typical late positive component (LPC) at 400-600 ms for emotion words compared to neutral, while the ASD group showed no LPC. The between-group difference in LPC amplitude was significant, suggesting that emotion words were processed differently by individuals with ASD, although their behavioral performance was similar to that of typical individuals

Abstract

In his first description of Autism Spectrum Disorders (ASD), Kanner emphasized emotional impairments by characterizing children with ASD as indifferent to other people, self-absorbed, emotionally cold, distanced, and retracted. Thereafter, emotional impairments became regarded as part of the social impairments of ASD, and research mostly focused on understanding how individuals with ASD recognize visual expressions of emotions from faces and body postures. However, it still remains unclear how emotions are processed outside of the visual domain. This systematic review aims to fill this gap by focusing on impairments of emotional language processing in ASD.
We systematically searched PubMed for papers published between 1990 and 2013 using standardized search terms. Studies show that people with ASD are able to correctly classify emotional language stimuli as emotionally positive or negative. However, processing of emotional language stimuli in ASD is associated with atypical patterns of attention and memory performance, as well as abnormal physiological and neural activity. Particularly, younger children with ASD have difficulties in acquiring and developing emotional concepts, and avoid using these in discourse. These emotional language impairments were not consistently associated with age, IQ, or level of development of language skills.
We discuss how emotional language impairments fit with existing cognitive theories of ASD, such as central coherence, executive dysfunction, and weak Theory of Mind. We conclude that emotional impairments in ASD may be broader than just a mere consequence of social impairments, and should receive more attention in future research

Abstract

The ability to map locations in the surrounding environment is crucial for any navigating animal. Decades of research on mammalian spatial representations suggest that environmental boundaries play a major role in both navigation behavior and hippocampal place coding. Although the capacity for spatial mapping is shared among vertebrates, including birds and fish, it is not yet clear whether such similarities in competence reflect common underlying mechanisms. The present study tests cue specificity in spatial mapping in zebrafish, by probing their use of various visual cues to encode the location of a nearby conspecific. The results suggest that untrained zebrafish, like other vertebrates tested so far, rely primarily on environmental boundaries to compute spatial relationships and, at the same time, use other visible features such as surface markings and freestanding objects as local cues to goal locations. We propose that the pattern of specificity in spontaneous spatial mapping behavior across vertebrates reveals cross-species commonalities in its underlying neural representations.