Publications

Displaying 901 - 949 of 949
  • Weber, A., & Cutler, A. (2004). Lexical competition in non-native spoken-word recognition. Journal of Memory and Language, 50(1), 1-25. doi:10.1016/S0749-596X(03)00105-0.

    Abstract

    Four eye-tracking experiments examined lexical competition in non-native spoken-word recognition. Dutch listeners hearing English fixated longer on distractor pictures with names containing vowels that Dutch listeners are likely to confuse with vowels in a target picture name (pencil, given target panda) than on less confusable distractors (beetle, given target bottle). English listeners showed no such viewing time difference. The confusability was asymmetric: given pencil as target, panda did not distract more than distinct competitors. Distractors with Dutch names phonologically related to English target names (deksel, ‘lid,’ given target desk) also received longer fixations than distractors with phonologically unrelated names. Again, English listeners showed no differential effect. With the materials translated into Dutch, Dutch listeners showed no activation of the English words (desk, given target deksel). The results motivate two conclusions: native phonemic categories capture second-language input even when stored representations maintain a second-language distinction; and lexical competition is greater for non-native than for native listeners.
  • Weber, K., & Indefrey, P. (2009). Syntactic priming in German–English bilinguals during sentence comprehension. Neuroimage, 46, 1164-1172. doi:10.1016/j.neuroimage.2009.03.040.

    Abstract

    A longstanding question in bilingualism is whether syntactic information is shared between the two language processing systems. We used an fMRI repetition suppression paradigm to investigate syntactic priming in reading comprehension in German–English late-acquisition bilinguals. In comparison to conventional subtraction analyses in bilingual experiments, repetition suppression has the advantage of being able to detect neuronal populations that are sensitive to properties that are shared by consecutive stimuli. In this study, we manipulated the syntactic structure between prime and target sentences. A sentence with a passive sentence structure in English was preceded either by a passive or by an active sentence in English or German. We looked for repetition suppression effects in left inferior frontal, left precentral and left middle temporal regions of interest. These regions were defined by a contrast of all non-target sentences in German and English versus the baseline of sentence-format consonant strings. We found decreases in activity (repetition suppression effects) in these regions of interest following the repetition of syntactic structure from the first to the second language and within the second language.
    Moreover, a separate behavioural experiment using a word-by-word reading paradigm similar to the fMRI experiment showed faster reading times for primed compared to unprimed English target sentences regardless of whether they were preceded by an English or a German sentence of the same structure.
    We conclude that there is interaction between the language processing systems and that at least some syntactic information is shared between a bilingual's languages with similar syntactic structures.

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  • Weber, A., & Paris, G. (2004). The origin of the linguistic gender effect in spoken-word recognition: Evidence from non-native listening. In K. Forbus, D. Gentner, & T. Tegier (Eds.), Proceedings of the 26th Annual Meeting of the Cognitive Science Society. Mahwah, NJ: Erlbaum.

    Abstract

    Two eye-tracking experiments examined linguistic gender effects in non-native spoken-word recognition. French participants, who knew German well, followed spoken instructions in German to click on pictures on a computer screen (e.g., Wo befindet sich die Perle, “where is the pearl”) while their eye movements were monitored. The name of the target picture was preceded by a gender-marked article in the instructions. When a target and a competitor picture (with phonologically similar names) were of the same gender in both German and French, French participants fixated competitor pictures more than unrelated pictures. However, when target and competitor were of the same gender in German but of different gender in French, early fixations to the competitor picture were reduced. Competitor activation in the non-native language was seemingly constrained by native gender information. German listeners showed no such viewing time difference. The results speak against a form-based account of the linguistic gender effect. They rather support the notion that the effect originates from the grammatical level of language processing.
  • Weber, A. (2009). The role of linguistic experience in lexical recognition [Abstract]. Journal of the Acoustical Society of America, 125, 2759.

    Abstract

    Lexical recognition is typically slower in L2 than in L1. Part of the difficulty comes from a not precise enough processing of L2 phonemes. Consequently, L2 listeners fail to eliminate candidate words that L1 listeners can exclude from competing for recognition. For instance, the inability to distinguish /r/ from /l/ in rocket and locker makes for Japanese listeners both words possible candidates when hearing their onset (e.g., Cutler, Weber, and Otake, 2006). The L2 disadvantage can, however, be dispelled: For L2 listeners, but not L1 listeners, L2 speech from a non-native talker with the same language background is known to be as intelligible as L2 speech from a native talker (e.g., Bent and Bradlow, 2003). A reason for this may be that L2 listeners have ample experience with segmental deviations that are characteristic for their own accent. On this account, only phonemic deviations that are typical for the listeners’ own accent will cause spurious lexical activation in L2 listening (e.g., English magic pronounced as megic for Dutch listeners). In this talk, I will present evidence from cross-modal priming studies with a variety of L2 listener groups, showing how the processing of phonemic deviations is accent-specific but withstands fine phonetic differences.
  • Weber, A., & Mueller, K. (2004). Word order variation in German main clauses: A corpus analysis. In Proceedings of the 20th International Conference on Computational Linguistics.

    Abstract

    In this paper, we present empirical data from a corpus study on the linear order of subjects and objects in German main clauses. The aim was to establish the validity of three well-known ordering constraints: given complements tend to occur before new complements, definite before indefinite, and pronoun before full noun phrase complements. Frequencies of occurrences were derived for subject-first and object-first sentences from the German Negra corpus. While all three constraints held on subject-first sentences, results for object-first sentences varied. Our findings suggest an influence of grammatical functions on the ordering of verb complements.
  • De Weert, C., & Levelt, W. J. M. (1976). Comparison of normal and dichoptic colour mixing. Vision Research, 16, 59-70. doi:10.1016/0042-6989(76)90077-8.

    Abstract

    Dichoptic mixtures of equiluminous components of different wavelengths were matched with a binocularly presented "monocular" mixture of appropriate chosen amounts of the same colour components. Stimuli were chosen from the region of 490-630 nm. Although satisfactory colour matches could be obtained, dichoptic mixtures differed from normal mixtures to a considerable extent. Midspectral stimuli tended to be more dominant in the dichoptic mixtures than either short or long wavelength stimuli. An attempt was made to describe the relation between monocular and dichoptic mixtures with one function containing a wavelength variable and an eye dominance parameter.
  • De Weert, C., & Levelt, W. J. M. (1976). Dichoptic brightness combinations for unequally coloured lights. Vision Research, 16, 1077-1086.
  • Wegener, C. (2005). Major word classes in Savosavo. Grazer Linguistische Studien, 64, 29-52.
  • Wells, J. B., Christiansen, M. H., Race, D. S., Acheson, D. J., & MacDonald, M. C. (2009). Experience and sentence processing: Statistical learning and relative clause comprehension. Cognitive Psychology, 58(2), 250-271. doi:10.1016/j.cogpsych.2008.08.002.

    Abstract

    Many explanations of the difficulties associated with interpreting object relative clauses appeal to the demands that object relatives make on working memory. MacDonald and Christiansen [MacDonald, M. C., & Christiansen, M. H. (2002). Reassessing working memory: Comment on Just and Carpenter (1992) and Waters and Caplan (1996). Psychological Review, 109, 35-54] pointed to variations in reading experience as a source of differences, arguing that the unique word order of object relatives makes their processing more difficult and more sensitive to the effects of previous experience than the processing of subject relatives. This hypothesis was tested in a large-scale study manipulating reading experiences of adults over several weeks. The group receiving relative clause experience increased reading speeds for object relatives more than for subject relatives, whereas a control experience group did not. The reading time data were compared to performance of a computational model given different amounts of experience. The results support claims for experience-based individual differences and an important role for statistical learning in sentence comprehension processes.
  • Wheeldon, L. R., & Levelt, W. J. M. (1995). Monitoring the time course of phonological encoding. Journal of Memory and Language, 34(3), 311-334. doi:10.1006/jmla.1995.1014.

    Abstract

    Three experiments examined the time course of phonological encoding in speech production. A new methodology is introduced in which subjects are required to monitor their internal speech production for prespecified target segments and syllables. Experiment 1 demonstrated that word initial target segments are monitored significantly faster than second syllable initial target segments. The addition of a concurrent articulation task (Experiment 1b) had a limited effect on performance, excluding the possibility that subjects are monitoring a subvocal articulation of the carrier word. Moreover, no relationship was observed between the pattern of monitoring latencies and the timing of the targets in subjects′ overt speech. Subjects are not, therefore, monitoring an internal phonetic representation of the carrier word. Experiment 2 used the production monitoring task to replicate the syllable monitoring effect observed in speech perception experiments: responses to targets were faster when they corresponded to the initial syllable of the carrier word than when they did not. We conclude that subjects are monitoring their internal generation of a syllabified phonological representation. Experiment 3 provides more detailed evidence concerning the time course of the generation of this representation by comparing monitoring latencies to targets within, as well as between, syllables. Some amendments to current models of phonological encoding are suggested in light of these results.
  • Widlok, T. (2004). Ethnography in language Documentation. Language Archive Newsletter, 1(3), 4-6.
  • Wilkins, D. (1995). Towards a Socio-Cultural Profile of the Communities We Work With. In D. Wilkins (Ed.), Extensions of space and beyond: manual for field elicitation for the 1995 field season (pp. 70-79). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.3513481.

    Abstract

    Field data are drawn from a particular speech community at a certain place and time. The intent of this survey is to enrich understanding of the various socio-cultural contexts in which linguistic and “cognitive” data may have been collected, so that we can explore the role which societal, cultural and contextual factors may play in this material. The questionnaire gives guidelines concerning types of ethnographic information that are important to cross-cultural and cross-linguistic enquiry, and will be especially useful to researchers who do not have specialised training in anthropology.
  • Wilkins, D., Pederson, E., & Levinson, S. C. (1995). Background questions for the "enter"/"exit" research. In D. Wilkins (Ed.), Extensions of space and beyond: manual for field elicitation for the 1995 field season (pp. 14-16). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.3003935.

    Abstract

    How do languages encode different kinds of movement, and what features do people pay attention to when describing motion events? This document outlines topics concerning the investigation of “enter” and “exit” events. It helps contextualise research tasks that examine this domain (see 'Motion Elicitation' and 'Enter/Exit animation') and gives some pointers about what other questions can be explored.
  • Wilkins, D. (1995). Motion elicitation: "moving 'in(to)'" and "moving 'out (of)'". In D. Wilkins (Ed.), Extensions of space and beyond: manual for field elicitation for the 1995 field season (pp. 4-12). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.3003391.

    Abstract

    How do languages encode different kinds of movement, and what features do people pay attention to when describing motion events? This task investigates the expression of “enter” and “exit” activities, that is, events involving motion in(to) and motion out (of) container-like items. The researcher first uses particular stimuli (a ball, a cup, rice, etc.) to elicit descriptions of enter/exit events from one consultant, and then asks another consultant to demonstrate the event based on these descriptions. See also the related entries Enter/Exit Animation and Background Questions for Enter/Exit Research.
  • Wilkins, D. P., & Hill, D. (1995). When "go" means "come": Questioning the basicness of basic motion verbs. Cognitive Linguistics, 6, 209-260. doi:10.1515/cogl.1995.6.2-3.209.

    Abstract

    The purpose of this paper is to question some of the basic assumpiions concerning motion verbs. In particular, it examines the assumption that "come" and "go" are lexical universals which manifest a universal deictic Opposition. Against the background offive working hypotheses about the nature of'come" and ''go", this study presents a comparative investigation of t wo unrelated languages—Mparntwe Arrernte (Pama-Nyungan, Australian) and Longgu (Oceanic, Austronesian). Although the pragmatic and deictic "suppositional" complexity of"come" and "go" expressions has long been recognized, we argue that in any given language the analysis of these expressions is much more semantically and systemically complex than has been assumed in the literature. Languages vary at the lexical semantic level äs t o what is entailed by these expressions, äs well äs differing äs t o what constitutes the prototype and categorial structure for such expressions. The data also strongly suggest that, ifthere is a lexical universal "go", then this cannof be an inherently deictic expression. However, due to systemic Opposition with "come", non-deictic "go" expressions often take on a deictic Interpretation through pragmatic attribution. Thus, this crosslinguistic investigation of "come" and "go" highlights the need to consider semantics and pragmatics äs modularly separate.
  • Willems, R. M., Toni, I., Hagoort, P., & Casasanto, D. (2009). Body-specific motor imagery of hand actions: Neural evidence from right- and left-handers. Frontiers in Human Neuroscience, 3: 39, pp. 39. doi:10.3389/neuro.09.039.2009.

    Abstract

    If motor imagery uses neural structures involved in action execution, then the neural correlates of imagining an action should differ between individuals who tend to execute the action differently. Here we report fMRI data showing that motor imagery is influenced by the way people habitually perform motor actions with their particular bodies; that is, motor imagery is ‘body-specific’ (Casasanto, 2009). During mental imagery for complex hand actions, activation of cortical areas involved in motor planning and execution was left-lateralized in right-handers but right-lateralized in left-handers. We conclude that motor imagery involves the generation of an action plan that is grounded in the participant’s motor habits, not just an abstract representation at the level of the action’s goal. People with different patterns of motor experience form correspondingly different neurocognitive representations of imagined actions.
  • Willems, R. M., & Hagoort, P. (2009). Broca's region: Battles are not won by ignoring half of the facts. Trends in Cognitive Sciences, 13(3), 101. doi:10.1016/j.tics.2008.12.001.
  • Willems, R. M., Ozyurek, A., & Hagoort, P. (2009). Differential roles for left inferior frontal and superior temporal cortex in multimodal integration of action and language. Neuroimage, 47, 1992-2004. doi:10.1016/j.neuroimage.2009.05.066.

    Abstract

    Several studies indicate that both posterior superior temporal sulcus/middle temporal gyrus (pSTS/MTG) and left inferior frontal gyrus (LIFG) are involved in integrating information from different modalities. Here we investigated the respective roles of these two areas in integration of action and language information. We exploited the fact that the semantic relationship between language and different forms of action (i.e. co-speech gestures and pantomimes) is radically different. Speech and co-speech gestures are always produced together, and gestures are not unambiguously understood without speech. On the contrary, pantomimes are not necessarily produced together with speech and can be easily understood without speech. We presented speech together with these two types of communicative hand actions in matching or mismatching combinations to manipulate semantic integration load. Left and right pSTS/MTG were only involved in semantic integration of speech and pantomimes. Left IFG on the other hand was involved in integration of speech and co-speech gestures as well as of speech and pantomimes. Effective connectivity analyses showed that depending upon the semantic relationship between language and action, LIFG modulates activation levels in left pSTS.

    This suggests that integration in pSTS/MTG involves the matching of two input streams for which there is a relatively stable common object representation, whereas integration in LIFG is better characterized as the on-line construction of a new and unified representation of the input streams. In conclusion, pSTS/MTG and LIFG are differentially involved in multimodal integration, crucially depending upon the semantic relationship between the input streams.

    Additional information

    Supplementary table S1
  • Willems, R. M., & Hagoort, P. (2009). Hand preference influences neural correlates of action observation. Brain Research, 1269, 90-104. doi:10.1016/j.brainres.2009.02.057.

    Abstract

    It has been argued that we map observed actions onto our own motor system. Here we added to this issue by investigating whether hand preference influences the neural correlates of action observation of simple, essentially meaningless hand actions. Such an influence would argue for an intricate neural coupling between action production and action observation, which goes beyond effects of motor repertoire or explicit motor training, as has been suggested before. Indeed, parts of the human motor system exhibited a close coupling between action production and action observation. Ventral premotor and inferior and superior parietal cortices showed differential activation for left- and right-handers that was similar during action production as well as during action observation. This suggests that mapping observed actions onto the observer's own motor system is a core feature of action observation - at least for actions that do not have a clear goal or meaning. Basic differences in the way we act upon the world are not only reflected in neural correlates of action production, but can also influence the brain basis of action observation.
  • Willems, R. M. (2009). Neural reflections of meaning in gesture, language, and action. PhD Thesis, Radboud University Nijmegen, Nijmegen.
  • Wittenburg, P., Skiba, R., & Trilsbeek, P. (2004). Technology and Tools for Language Documentation. Language Archive Newsletter, 1(4), 3-4.
  • Wittenburg, P. (2004). The IMDI metadata concept. In S. F. Ferreira (Ed.), Workingmaterial on Building the LR&E Roadmap: Joint COCOSDA and ICCWLRE Meeting, (LREC2004). Paris: ELRA - European Language Resources Association.
  • Wittenburg, P., Skiba, R., & Trilsbeek, P. (2005). The language archive at the MPI: Contents, tools, and technologies. Language Archives Newsletter, 5, 7-9.
  • Wittenburg, P. (2004). Training Course in Lithuania. Language Archive Newsletter, 1(2), 6-6.
  • Wittenburg, P., Brugman, H., Broeder, D., & Russel, A. (2004). XML-based language archiving. In Workshop Proceedings on XML-based Richly Annotaded Corpora (LREC2004) (pp. 63-69). Paris: ELRA - European Language Resources Association.
  • Wittenburg, P., Gulrajani, G., Broeder, D., & Uneson, M. (2004). Cross-disciplinary integration of metadata descriptions. In M. Lino, M. Xavier, F. Ferreira, R. Costa, & R. Silva (Eds.), Proceedings of the 4th International Conference on Language Resources and Evaluation (LREC2004) (pp. 113-116). Paris: ELRA - European Language Resources Association.
  • Wittenburg, P., Dirksmeyer, R., Brugman, H., & Klaas, G. (2004). Digital formats for images, audio and video. Language Archive Newsletter, 1(1), 3-6.
  • Wittenburg, P., Johnson, H., Buchhorn, M., Brugman, H., & Broeder, D. (2004). Architecture for distributed language resource management and archiving. In M. Lino, M. Xavier, F. Ferreira, R. Costa, & R. Silva (Eds.), Proceedings of the 4th International Conference on Language Resources and Evaluation (LREC2004) (pp. 361-364). Paris: ELRA - European Language Resources Association.
  • Wittenburg, P. (2004). International Expert Meeting on Access Management for Distributed Language Archives. Language Archive Newsletter, 1(3), 12-12.
  • Wittenburg, P. (2004). Final review of INTERA. Language Archive Newsletter, 1(4), 11-12.
  • Wittenburg, P. (2004). LinguaPax Forum on Language Diversity, Sustainability, and Peace. Language Archive Newsletter, 1(3), 13-13.
  • Wittenburg, P. (2004). LREC conference 2004. Language Archive Newsletter, 1(3), 12-13.
  • Wittenburg, P. (2004). News from the Archive of the Max Planck Institute for Psycholinguistics. Language Archive Newsletter, 1(4), 12-12.
  • Wohlgemuth, J., & Dirksmeyer, T. (Eds.). (2005). Bedrohte Vielfalt. Aspekte des Sprach(en)tods – Aspects of language death. Berlin: Weißensee.

    Abstract

    About 5,000 languages are spoken in the world today. More than half of them have less than 10,000 speakers, a quarter of them even fewer than 1,000. The majority of these “small” languages will not live to see the end of this century; some estimates predict that no more than a dozen languages will still be spoken by the turn of the next millennium. This collection of papers approaches the subject of language extinction through five major topics: general aspects of language death, case studies, endangered subsystems, language protection and revitalization, language ecology. In 24 articles, the authors address the causes, manifestations, and consequences of language endangerment and extinction as well as the linguistic and social changes associated with it, drawing examples from a large number of languages.
  • Won, S.-O., Hu, I., Kim, M.-Y., Bae, J.-M., Kim, Y.-M., & Byun, K.-S. (2009). Theory and practice of Sign Language interpretation. Pyeongtaek: Korea National College of Rehabilitation & Welfare.
  • Wood, N. (2009). Field recording for dummies. In A. Majid (Ed.), Field manual volume 12 (pp. V). Nijmegen: Max Planck Institute for Psycholinguistics.
  • Xiao, M., Kong, X., Liu, J., & Ning, J. (2009). TMBF: Bloom filter algorithms of time-dependent multi bit-strings for incremental set. In Proceedings of the 2009 International Conference on Ultra Modern Telecommunications & Workshops.

    Abstract

    Set is widely used as a kind of basic data structure. However, when it is used for large scale data set the cost of storage, search and transport is overhead. The bloom filter uses a fixed size bit string to represent elements in a static set, which can reduce storage space and search cost that is a fixed constant. The time-space efficiency is achieved at the cost of a small probability of false positive in membership query. However, for many applications the space savings and locating time constantly outweigh this drawback. Dynamic bloom filter (DBF) can support concisely representation and approximate membership queries of dynamic set instead of static set. It has been proved that DBF not only possess the advantage of standard bloom filter, but also has better features when dealing with dynamic set. This paper proposes a time-dependent multiple bit-strings bloom filter (TMBF) which roots in the DBF and targets on dynamic incremental set. TMBF uses multiple bit-strings in time order to present a dynamic increasing set and uses backward searching to test whether an element is in a set. Based on the system logs from a real P2P file sharing system, the evaluation shows a 20% reduction in searching cost compared to DBF.
  • Zeshan, U. (2005). Sign languages. In M. Haspelmath, M. S. Dryer, D. Gil, & B. Comrie (Eds.), The world atlas of language structures (pp. 558-559). Oxford: Oxford University Press.
  • Zeshan, U. (2005). Question particles in sign languages. In M. Haspelmath, M. S. Dryer, D. Gil, & B. Comrie (Eds.), The world atlas of language structures (pp. 564-567). Oxford: Oxford University Press.
  • Zeshan, U., & Panda, S. (2005). Professional course in Indian sign language. Mumbai: Ali Yavar Jung National Institute for the Hearing Handicapped.
  • Zeshan, U., Pfau, R., & Aboh, E. (2005). When a wh-word is not a wh-word: the case of Indian sign language. In B. Tanmoy (Ed.), Yearbook of South Asian languages and linguistics 2005 (pp. 11-43). Berlin: Mouton de Gruyter.
  • Zeshan, U. (2004). Basic English course taught in Indian Sign Language (Ali Yavar Young National Institute for Hearing Handicapped, Ed.). National Institute for the Hearing Handicapped: Mumbai.
  • Zeshan, U. (2004). Interrogative constructions in sign languages - Cross-linguistic perspectives. Language, 80(1), 7-39.

    Abstract

    This article reports on results from a broad crosslinguistic study based on data from thirty-five signed languages around the world. The study is the first of its kind, and the typological generalizations presented here cover the domain of interrogative structures as they appear across a wide range of geographically and genetically distinct signed languages. Manual and nonmanual ways of marking basic types of questions in signed languages are investigated. As a result, it becomes clear that the range of crosslinguistic variation is extensive for some subparameters, such as the structure of question-word paradigms, while other parameters, such as the use of nonmanual expressions in questions, show more similarities across signed languages. Finally, it is instructive to compare the findings from signed language typology to relevant data from spoken languages at a more abstract, crossmodality level.
  • Zeshan, U., Vasishta, M. N., & Sethna, M. (2005). Implementation of Indian Sign Language in educational settings. Asia Pacific Disability Rehabilitation Journal, 16(1), 16-40.

    Abstract

    This article reports on several sub-projects of research and development related to the use of Indian Sign Language in educational settings. In many countries around the world, sign languages are now recognised as the legitimate, full-fledged languages of the deaf communities that use them. In India, the development of sign language resources and their application in educational contexts, is still in its initial stages. The work reported on here, is the first principled and comprehensive effort of establishing educational programmes in Indian Sign Language at a national level. Programmes are of several types: a) Indian Sign Language instruction for hearing people; b) sign language teacher training programmes for deaf people; and c) educational materials for use in schools for the Deaf. The conceptual approach used in the programmes for deaf students is known as bilingual education, which emphasises the acquisition of a first language, Indian Sign Language, alongside the acquisition of spoken languages, primarily in their written form.
  • Zeshan, U. (2004). Hand, head and face - negative constructions in sign languages. Linguistic Typology, 8(1), 1-58. doi:10.1515/lity.2004.003.

    Abstract

    This article presents a typology of negative constructions across a substantial number of sign languages from around the globe. After situating the topic within the wider context of linguistic typology, the main negation strategies found across sign languages are described. Nonmanual negation includes the use of head movements and facial expressions for negation and is of great importance in sign languages as well as particularly interesting from a typological point of view. As far as manual signs are concerned, independent negative particles represent the dominant strategy, but there are also instances of irregular negation in most sign languages. Irregular negatives may take the form of suppletion, cliticisation, affixing, or internal modification of a sign. The results of the study lead to interesting generalisations about similarities and differences between negatives in signed and spoken languages.
  • Zeshan, U. (2005). Irregular negatives in sign languages. In M. Haspelmath, M. S. Dryer, D. Gil, & B. Comrie (Eds.), The world atlas of language structures (pp. 560-563). Oxford: Oxford University Press.
  • Zhang, J., Bao, S., Furumai, R., Kucera, K. S., Ali, A., Dean, N. M., & Wang, X.-F. (2005). Protein phosphatase 5 is required for ATR-mediated checkpoint activation. Molecular and Cellular Biology, 25, 9910-9919. doi:10.1128/​MCB.25.22.9910-9919.2005.

    Abstract

    In response to DNA damage or replication stress, the protein kinase ATR is activated and subsequently transduces genotoxic signals to cell cycle control and DNA repair machinery through phosphorylation of a number of downstream substrates. Very little is known about the molecular mechanism by which ATR is activated in response to genotoxic insults. In this report, we demonstrate that protein phosphatase 5 (PP5) is required for the ATR-mediated checkpoint activation. PP5 forms a complex with ATR in a genotoxic stress-inducible manner. Interference with the expression or the activity of PP5 leads to impairment of the ATR-mediated phosphorylation of hRad17 and Chk1 after UV or hydroxyurea treatment. Similar results are obtained in ATM-deficient cells, suggesting that the observed defect in checkpoint signaling is the consequence of impaired functional interaction between ATR and PP5. In cells exposed to UV irradiation, PP5 is required to elicit an appropriate S-phase checkpoint response. In addition, loss of PP5 leads to premature mitosis after hydroxyurea treatment. Interestingly, reduced PP5 activity exerts differential effects on the formation of intranuclear foci by ATR and replication protein A, implicating a functional role for PP5 in a specific stage of the checkpoint signaling pathway. Taken together, our results suggest that PP5 plays a critical role in the ATR-mediated checkpoint activation.
  • Zwitserlood, I. (2009). Het Corpus NGT. Levende Talen Magazine, 6, 44-45.

    Abstract

    The Corpus NGT
  • Zwitserlood, I. (2009). Het Corpus NGT en de dagelijkse lespraktijk (1). Levende Talen Magazine, 8, 40-41.

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