Displaying 1 - 19 of 19
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Alagöz, G., Molz, B., Eising, E., Schijven, D., Francks, C., Stein, J. L., & Fisher, S. E. (2022). Using neuroimaging genomics to investigate the evolution of human brain structure. Poster presented at the Reconstructing the human past: Using ancient and modern genomics symposium (EMBL), Heidelberg, Germany.
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Amelink, J., Postema, M., Kong, X., Sha, Z., Schijven, D., Molz, B., Joliot, M., Fisher, S. E., & Francks, C. (2022). Genetic correlates of intra- and interhemispheric resting state functional language connectivity. Poster presented at the IMPRS Conference 2022, Nijmegen, the Netherlands.
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Amelink, J., Postema, M., Kong, X., Sha, Z., Schijven, D., Molz, B., Joliot, M., Fisher, S. E., & Francks, C. (2022). Genetic correlates of intra- and interhemispheric resting state functional language connectivity. Talk presented at the Neuromatch Conference (NMC 2022). online. 2022-09-27 - 2022-09-28.
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Gunz, P., Molz, B., Eising, E., Alagöz, G., Schijven, D., Francks, C., & Fisher, S. E. (2022). Scratching the surface: The genetic bases of brain globularity. Talk presented at the European Society for the study of Human Evolution meeting (ESHE 2022). Tübingen, Germany. 2022-09-21 - 2022-09-25.
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Molz, B., Gunz, P., Eising, E., Alagöz, G., Schijven, D., Francks, C., & Fisher, S. E. (2022). Deciphering the underlying biological mechanisms of modern human brain shape. Talk presented at the IMPRS Conference 2022. Nijmegen, the Netherlands. 2022-06-01 - 2022-06-03.
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Molz, B., Gunz, P., Eising, E., Alagöz, G., Schijven, D., Francks, C., & Fisher, S. E. (2022). Insights into the biological bases of modern human brain shape. Poster presented at the 28th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2022), Glasgow, Scotland.
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Schijven, D., Postema, M., ENIGMA-Schizophrenia Working Group, Fisher, S. E., Franke, B., Glahn, D. C., Gur, R. C., Hashimoto, R., Jahanshad, N., Luders, E., Medland, S. E., Thompson, P. M., Turner, J. A., Van Erp, T. G. M., & Francks, C. (2022). Large-scale analysis of brain structural asymmetries in schizophrenia via the ENIGMA Consortium. Poster presented at the 28th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2022), Glasgow, Scotland.
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Sha, Z., Schijven, D., Fisher, S. E., & Francks, C. (2022). Genetic architecture of the white matter connectome of the human brain. Talk presented at the Annual Meeting of International Behavioural and Neural Genetics Society. Memphis, TN, USA. 2022-05-24 - 2022-05-27.
Abstract
White matter tracts form the structural basis of large-scale functional networks in the human brain. We applied brain-wide tractography to diffusion images from 30,810 adult participants (UK Biobank), and found significant heritability for 90 regional connectivity measures and 851 fiber tracts. Multivariate genome-wide association analyses identified 355 independently associated lead SNPs across the genome, of which 77% were not previously associated with human brain metrics. Enrichment analyses implicated neurodevelopmental processes including neurogenesis, neural differentiation, neural migration, neural projection guidance, and axon development, as well as prenatal brain expression especially in stem cells, astrocytes, microglia and neurons. We used the multivariate association profiles of lead SNPs to identify 26 genomic loci implicated in structural connectivity between core regions of the left-hemisphere language network, and also identified 6 loci associated with hemispheric left-right asymmetry of structural connectivity. Polygenic scores for schizophrenia, bipolar disorder, autism spectrum disorder, attention-deficit hyperactivity disorder, reading ability, left-handedness, Alzheimer’s disease, amyotrophic lateral sclerosis, and epilepsy showed significant multivariate associations with structural connectivity, each implicating specific sets of brain regions with trait-relevant functional profiles. This large-scale mapping study revealed common genetic contributions to the human brain's structural connectome in the general adult population, and its links with polygenic disposition to brain disorders and behavioral traits. -
Sha, Z., Schijven, D., Fisher, S. E., & Francks, C. (2022). Genetic architecture of the white matter connectome of the human brain. Talk presented at the World Congress of Psychiatric Genetics (WCPG 2022). Florence, Italy. 2022-09-13 - 2022-09-17.
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Sha, Z., Schijven, D., Fisher, S. E., & Francks, C. (2022). Genetic architecture of the white matter connectome of the human brain. Poster presented at the FENS Forum 2022, Paris, France.
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Sha, Z., Schijven, D., Fisher, S. E., & Francks, C. (2022). Genetic architecture of the white matter connectome of the human brain. Talk presented at Theme Discussion (RadboudUMC). online. 2022-10-21.
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Alagöz, G., Molz, B., Eising, E., Schijven, D., Francks, C., Stein, J., & Fisher, S. E. (2021). Common DNA variants associated with neuroanatomy of language-related cortical regions are enriched in human gained enhancers. Poster presented at the Wellcome Trust conference Human Evolution - From Fossils to Ancient and Modern Genomes, online.
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Den Hoed, J., Van der Spek, J., Snijders Blok, L., Dingemans, A. J. M., Schijven, D., Barakat, T. S., Bebin, E. M., Beck-Wödl, S., Beunders, G., Brown, N. J., Brunet, T., Brunner, H. G., Campeau, P. M., Čuturilo, G., Gilissen, C., Haack, T. B., Husain, R. A., Kamien, B., Lim, S. C., Magg, J. and 16 moreDen Hoed, J., Van der Spek, J., Snijders Blok, L., Dingemans, A. J. M., Schijven, D., Barakat, T. S., Bebin, E. M., Beck-Wödl, S., Beunders, G., Brown, N. J., Brunet, T., Brunner, H. G., Campeau, P. M., Čuturilo, G., Gilissen, C., Haack, T. B., Husain, R. A., Kamien, B., Lim, S. C., Magg, J., Maver, A., Monteil, D. C., Ockeloen, C. W., Richmond, C., Riess, A., Schwaibold, E. M. C., Simon, M. E. H., Spranger, S., Tan, T. Y., Thompson, M. L., De Vries, B. B., Wilkins, E. J., Willemsen, M. H., Vissers, L. E. L. M., Fisher, S. E., & Kleefstra, T. (2021). Inherited variants in CHD3 demonstrate variable expressivity in Snijders Blok-Campeau syndrome. Poster presented at the ASHG 2021 Annual Meeting, online.
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Molz, B., Alagöz, G., Schijven, D., Francks, C., Stein, J., & Fisher, S. E. (2021). Cortical surface area is influenced by genetic variation in enhancers gained during human evolution. Poster presented at the 27th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2021), online.
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Molz, B., Gunz, P., Schijven, D., Francks, C., & Fisher, S. E. (2021). Deciphering the biological bases of endocranial globularity in modern humans. Talk presented at the Wellcome Trust conference Human Evolution - From Fossils to Ancient and Modern Genomes. online. 2021-11-02 - 2021-11-04.
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Schijven, D., Fisher, S. E., Franke, B., Glahn, D. C., Gur, R. C., Hashimoto, R., Jahanshad, N., Medland, S. E., Thompson, P. M., Van Erp, T. G. M., Turner, J. A., Francks, C., & ENIGMA-Schizophrenia working group (2021). Large-scale ENIGMA Consortium analysis of brain anatomical asymmetries in schizophrenia. Poster presented at the 2021 Society of Biological Psychiatry (SOBP) Annual Meeting, online.
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Sha, Z., Schijven, D., & Francks, C. (2021). Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain masculinization. Poster presented at the 51st Annual Meeting of the Behavior Genetics Association, Online.
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Sha, Z., Schijven, D., & Francks, C. (2021). Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain masculinization. Talk presented at 22nd Annual Genes, Brain & Behavior Meeting. Online. 2021-05-10 - 2021-05-15.
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Sha, Z., Schijven, D., & Francks, C. (2021). Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain masculinization. Talk presented at the World Congress of Psychiatric Genetics (WCPG 2021). Online. 2021-10-11 - 2021-10-15.
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