Publications

Abstract

Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.

Abstract

Alphabetic orthographies show more or less ambiguous relations between spelling and sound patterns. In transparent orthographies, like Italian, the pronunciation can be predicted from the spelling and vice versa. Opaque orthographies, like English, often display unpredictable spelling–sound correspondences. In this paper we present a computational analysis of word-initial bi-directional spelling–sound correspondences for Dutch, English, French, German, and Hungarian, stated in entropy values for various grain sizes. This allows us to position the five languages on the continuum from opaque to transparent orthographies, both in spelling-to-sound and sound-to-spelling directions. The analysis is based on metrics derived from information theory, and therefore independent of any specific theory of visual word recognition as well as of any specific theoretical approach of orthography.

Abstract

Prosodic juncture concerns the compartmentalization and partitioning of syntactic entities in spoken discourse by means of prosody. It has been argued that the Intonation Unit, defined by internal criteria and prosodic boundary phenomena (e.g., final lengthening, pitch reset, pauses), encapsulates the basic structural unit of spoken Modern Hebrew.

Abstract

Fricative consonants in Hebrew can be divided into bgdkpt and sibilants (ז, ס, צ, שׁ, שׂ). Hebrew sibilants have been argued to stem from Proto-Semitic affricates, laterals, interdentals and /s/. In standard Israeli Hebrew the sibilants are pronounced as [s] (ס and שׂ), [ʃ] (שׁ), [z] (ז), [ʦ] (צ).

Abstract

The oral fluency level of an L2 speaker is often used as a measure in assessing language proficiency. The present study reports on four experiments investigating the contributions of three fluency aspects (pauses, speed and repairs) to perceived fluency. In Experiment 1 untrained raters evaluated the oral fluency of L2 Dutch speakers. Using specific acoustic measures of pause, speed and repair phenomena, linear regression analyses revealed that pause and speed measures best predicted the subjective fluency ratings, and that repair measures contributed only very little. A second research question sought to account for these results by investigating perceptual sensitivity to acoustic pause, speed and repair phenomena, possibly accounting for the results from Experiment 1. In Experiments 2–4 three new groups of untrained raters rated the same L2 speech materials from Experiment 1 on the use of pauses, speed and repairs. A comparison of the results from perceptual sensitivity (Experiments 2–4) with fluency perception (Experiment 1) showed that perceptual sensitivity alone could not account for the contributions of the three aspects to perceived fluency. We conclude that listeners weigh the importance of the perceived aspects of fluency to come to an overall judgment.

Abstract

A central motif in neuronal networks is convergence, linking several input neurons to one target neuron. In visual cortex, convergence renders target neurons responsive to complex stimuli. Yet, convergence typically sends multiple stimuli to a target, and the behaviorally relevant stimulus must be selected. We used two stimuli, activating separate electrocorticographic V1 sites, and both activating an electrocorticographic V4 site equally strongly. When one of those stimuli activated one V1 site, it gamma synchronized (60-80 Hz) to V4. When the two stimuli activated two V1 sites, primarily the relevant one gamma synchronized to V4. Frequency bands of gamma activities showed substantial overlap containing the band of interareal coherence. The relevant V1 site had its gamma peak frequency 2-3 Hz higher than the irrelevant V1 site and 4-6 Hz higher than V4. Gamma-mediated interareal influences were predominantly directed from V1 to V4. We propose that selective synchronization renders relevant input effective, thereby modulating effective connectivity.

Abstract

How are space and time represented in the human mind? Here we evaluate two theoretical proposals, one suggesting a symmetric relationship between space and time (ATOM theory) and the other an asymmetric relationship (metaphor theory). In Experiment 1, Dutch-speakers saw 7-letter nouns that named concrete objects of various spatial lengths (tr. pencil, bench, footpath) and estimated how much time they remained on the screen. In Experiment 2, participants saw nouns naming temporal events of various durations (tr. blink, party, season) and estimated the words’ spatial length. Nouns that named short objects were judged to remain on the screen for a shorter time, and nouns that named longer objects to remain for a longer time. By contrast, variations in the duration of the event nouns’ referents had no effect on judgments of the words’ spatial length. This asymmetric pattern of cross-dimensional interference supports metaphor theory and challenges ATOM.

Abstract

Why do people accommodate to each other’s linguistic behavior? Studies of natural interactions (Giles, Taylor & Bourhis, 1973) suggest that speakers accommodate to achieve interactional goals, influencing what their interlocutor thinks or feels about them. But is this the only reason speakers accommodate? In real-world conversations, interactional motivations are ubiquitous, making it difficult to assess the extent to which they drive accommodation. Do speakers still accommodate even when interactional goals cannot be achieved, for instance, when their interlocutor cannot interpret their accommodation behavior? To find out, we asked participants to enter an immersive virtual reality (VR) environment and to converse with a virtual interlocutor. Participants accommodated to the speech rate of their virtual interlocutor even though he could not interpret their linguistic behavior, and thus accommodation could not possibly help them to achieve interactional goals. Results show that accommodation does not require explicit interactional goals, and suggest other social motivations for accommodation.

Abstract

There are two competing hypotheses for the origin of the Indo-European language family. The conventional view places the homeland in the Pontic steppes about 6000 years ago. An alternative hypothesis claims that the languages spread from Anatolia with the expansion of farming 8000 to 9500 years ago. We used Bayesian phylogeographic approaches, together with basic vocabulary data from 103 ancient and contemporary Indo-European languages, to explicitly model the expansion of the family and test these hypotheses. We found decisive support for an Anatolian origin over a steppe origin. Both the inferred timing and root location of the Indo-European language trees fit with an agricultural expansion from Anatolia beginning 8000 to 9500 years ago. These results highlight the critical role that phylogeographic inference can play in resolving debates about human prehistory.

Abstract

Attempts to explain children's grammatical development often assume a close initial match between units of meaning and units of form; for example, agents are said to map to sentence-subjects and actions to verbs. The meanings themselves, according to this view, are not influenced by language, but reflect children's universal non-linguistic way of understanding the world. This paper argues that, contrary to this position, meaning as it is expressed in children's early sentences is, from the beginning, organized on the basis of experience with the grammar and lexicon of a particular language. As a case in point, children learning English and Korean are shown to express meanings having to do with directed motion according to language-specific principles of semantic and grammatical structuring from the earliest stages of word combination.

Abstract

How similar are the event concepts encoded by different languages? So far, few event domains have been investigated in any detail. The PUT project extends the systematic cross-linguistic exploration of event categorisation to a new domain, that of placement events (putting things in places and removing them from places). The goal of this task is to explore cross-linguistic universality and variability in the semantic categorisation of placement events (e.g., ‘putting a cup on the table’).

Abstract

Reprinted from Bowerman, M. (1973). Structural relationships in children's utterances: Semantic or syntactic? In T. Moore (Ed.), Cognitive development and the acquisition of language (pp. 197 213). New York: Academic Press

Abstract

Selected spontaneous errors of word choice made between the ages of about 2 and 5 by 2 children whose language development has been followed longitudinally were analyzed for clues to semantic development. The errors involved the children's occasional replacement of a contextually required word by a semantically similar word after weeks or months of using both words appropriately. Because the errors were not present from the beginning and because correct usage prevailed most of the time, the errors cannot be explained by existing accounts of semantic development, which ascribe children's word-choice errors to initial linguistic immaturity. A plausible alternative account likens the errors to adult "slips of the tongue" in which the speaker, in the process of constructing a sentence to express a given meaning, chooses incorrectly among competing semantically related words. Interpreted in this way, the errors indicate that the process of drawing words into structured semantic systems based on shared meaning components begins much earlier than experimental studies have suggested. They also provide evidence for certain differences between children and adults in the planning and monitoring of speech.

Abstract

This study considers the role of verbal working memory in sentence comprehension in typically developing English-speaking children. Fifty-six (N = 56) children aged 4;0–6;6 completed a test of language comprehension that contained sentences which varied in complexity, standardized tests of vocabulary and nonverbal intelligence, and three tests of memory that measured the three verbal components of Baddeley's model of Working Memory (WM): the phonological loop, the episodic buffer, and the central executive. The results showed that children experienced most difficulty comprehending sentences that contained noncanonical word order (passives and object relative clauses). A series of linear mixed effects models were run to analyze the contribution of each component of WM to sentence comprehension. In contrast to most previous studies, the measure of the central executive did not predict comprehension accuracy. A canonicity by episodic buffer interaction showed that the episodic buffer measure was positively associated with better performance on the noncanonical sentences. The results are discussed with reference to capacity-limit and experience-dependent approaches to language comprehension.

Abstract

To clarify whether the neural pathways concerning color processing are the same for natural objects, for artifacts objects and for non-sense objects we examined functional magnetic resonance imaging (FMRI) responses during a covert naming task including the factors color (color vs. black&white (B&W)) and stimulus type (natural vs. artifacts vs. non-sense objects). Our results indicate that the superior parietal lobule and precuneus (BA 7) bilaterally, the right hippocampus and the right fusifom gyrus (V4) make part of a network responsible for color processing both for natural and artifacts objects, but not for non-sense objects. The recognition of non-sense colored objects compared to the recognition of color objects activated the posterior cingulate/precuneus (BA 7/23/31), suggesting that color attribute induces the mental operation of trying to associate a non-sense composition with a familiar objects. When color objects (both natural and artifacts) were contrasted with color nonobjects we observed activations in the right parahippocampal gyrus (BA 35/36), the superior parietal lobule (BA 7) bilaterally, the left inferior middle temporal region (BA 20/21) and the inferior and superior frontal regions (BA 10/11/47). These additional activations suggest that colored objects recruit brain regions that are related to visual semantic information/retrieval and brain regions related to visuo-spatial processing. Overall, the results suggest that color information is an attribute that improve object recognition (based on behavioral results) and activate a specific neural network related to visual semantic information that is more extensive than for B&W objects during object recognition

Abstract

In this study, we investigated the level of visual processing at which surface colour information improves the naming of colour diagnostic and noncolour diagnostic objects. Continuous electroencephalograms were recorded while participants performed a visual object naming task in which coloured and black-and-white versions of both types of objects were presented. The black-and-white and the colour presentations were compared in two groups of event-related potentials (ERPs): (1) The P1 and N1 components, indexing early visual processing; and (2) the N300 and N400 components, which index late visual processing. A colour effect was observed in the P1 and N1 components, for both colour and noncolour diagnostic objects. In addition, for colour diagnostic objects, a colour effect was observed in the N400 component. These results suggest that colour information is important for the naming of colour and noncolour diagnostic objects at different levels of visual processing. It thus appears that the visual system uses colour information, during naming of both object types, at early visual stages; however, for the colour diagnostic objects naming, colour information is also recruited during the late visual processing stages.

Abstract

The cognitive processes involved in object recognition remain a mystery to the cognitive
sciences. We know that the visual system recognizes objects via multiple features, including
shape, color, texture, and motion characteristics. However, the way these features are
combined to recognize objects is still an open question. The purpose of this contribution is to
review the research about the specific role of color information in object recognition. Given
that the human brain incorporates specialized mechanisms to handle color perception in the
visual environment, it is a fair question to ask what functional role color might play in
everyday vision.

Abstract

In order to clarify whether the influence of color knowledge information in object recognition depends on the presence of the appropriate surface color, we designed a name—object verification task. The relationship between color and shape information provided by the name and by the object photo was manipulated in order to assess color interference independently of shape interference. We tested three different versions for each object: typically colored, black and white, and nontypically colored. The response times on the nonmatching trials were used to measure the interference between the name and the photo. We predicted that the more similar the name and the photo are, the longer it would take to respond. Overall, the color similarity effect disappeared in the black-and-white and nontypical color conditions, suggesting that the influence of color knowledge on object recognition depends on the presence of the appropriate surface color information.

Abstract

In this study, we used event-related potentials (ERPs) to evaluate the contribution of surface color and color knowledge information in object identification. We constructed two color-object verification tasks – a surface and a knowledge verification task – using high color diagnostic objects; both typical and atypical color versions of the same object were presented. Continuous electroencephalogram was recorded from 26 subjects. A cluster randomization procedure was used to explore the differences between typical and atypical color objects in each task. In the color knowledge task, we found two significant clusters that were consistent with the N350 and late positive complex (LPC) effects. Atypical color objects elicited more negative ERPs compared to typical color objects. The color effect found in the N350 time window suggests that surface color is an important cue that facilitates the selection of a stored object representation from long-term memory. Moreover, the observed LPC effect suggests that surface color activates associated semantic knowledge about the object, including color knowledge representations. We did not find any significant differences between typical and atypical color objects in the surface color verification task, which indicates that there is little contribution of color knowledge to resolve the surface color verification. Our main results suggest that surface color is an important visual cue that triggers color knowledge, thereby facilitating object identification.

Abstract

Humans display structural and functional asymmetries in brain organization, strikingly with respect to language and handedness. The molecular basis of these asymmetries is unknown. We report a genome-wide association study meta-analysis for a quantitative measure of relative hand skill in individuals with dyslexia [reading disability (RD)] (n = 728). The most strongly associated variant, rs7182874 (P = 8.68×10−9), is located in PCSK6, further supporting an association we previously reported. We also confirmed the specificity of this association in individuals with RD; the same locus was not associated with relative hand skill in a general population cohort (n = 2,666). As PCSK6 is known to regulate NODAL in the development of left/right (LR) asymmetry in mice, we developed a novel approach to GWAS pathway analysis, using gene-set enrichment to test for an over-representation of highly associated variants within the orthologs of genes whose disruption in mice yields LR asymmetry phenotypes. Four out of 15 LR asymmetry phenotypes showed an over-representation (FDR≤5%). We replicated three of these phenotypes; situs inversus, heterotaxia, and double outlet right ventricle, in the general population cohort (FDR≤5%). Our findings lead us to propose that handedness is a polygenic trait controlled in part by the molecular mechanisms that establish LR body asymmetry early in development.

Abstract

Multivariate pattern classification methods are increasingly applied to neuroimaging data in the context of both fundamental research and in brain-computer interfacing approaches. Such methods provide a framework for interpreting measurements made at the single-trial level with respect to a set of two or more distinct mental states. Here, we define an approach in which the output of a binary classifier trained on data from an auditory mismatch paradigm can be used for online tracking of perception and as a neurofeedback signal. The auditory mismatch paradigm is known to induce distinct perceptual states related to the presentation of high- and low-probability stimuli, which are reflected in event-related potential (ERP) components such as the mismatch negativity (MMN). The first part of this paper illustrates how pattern classification methods can be applied to data collected in an MMN paradigm, including discussion of the optimization of preprocessing steps, the interpretation of features and how the performance of these methods generalizes across individual participants and measurement sessions. We then go on to show that the output of these decoding methods can be used in online settings as a continuous index of single-trial brain activation underlying perceptual discrimination. We conclude by discussing several potential domains of application, including neurofeedback, cognitive monitoring and passive brain-computer interfaces

Abstract

Brain-computer interfaces (BCIs) are systems that use real-time analysis of neuroimaging data to determine the mental state of their user for purposes such as providing neurofeedback. Here, we investigate the feasibility of a BCI based on speech perception. Multivariate pattern classification methods were applied to single-trial EEG data collected during speech perception by native and non-native speakers. Two principal questions were asked: 1) Can differences in the perceived categories of pairs of phonemes be decoded at the single-trial level? 2) Can these same categorical differences be decoded across participants, within or between native-language groups? Results indicated that classification performance progressively increased with respect to the categorical status (within, boundary or across) of the stimulus contrast, and was also influenced by the native language of individual participants. Classifier performance showed strong relationships with traditional event-related potential measures and behavioral responses. The results of the cross-participant analysis indicated an overall increase in average classifier performance when trained on data from all participants (native and non-native). A second cross-participant classifier trained only on data from native speakers led to an overall improvement in performance for native speakers, but a reduction in performance for non-native speakers. We also found that the native language of a given participant could be decoded on the basis of EEG data with accuracy above 80%. These results indicate that electrophysiological responses underlying speech perception can be decoded at the single-trial level, and that decoding performance systematically reflects graded changes in the responses related to the phonological status of the stimuli. This approach could be used in extensions of the BCI paradigm to support perceptual learning during second language acquisition

Abstract

The present study used electrophysiological and behavioral measures to investigate the perception of an English stop consonant contrast by native English listeners and by native Dutch listeners who were highly proficient in English. A /ba/-/pa/ continuum was created from a naturally produced /pa/ token by removing successive periods of aspiration, thus reducing the voice onset time. Although aspiration is a relevant cue for distinguishing voiced and unvoiced labial stop consonants (/b/ and /p/) in English, prevoicing is the primary cue used to distinguish between these categories in Dutch. In the electrophysiological experiment, participants listened to oddball sequences containing the standard /pa/ stimulus and one of three deviant stimuli while the mismatch-negativity response was measured. Participants then completed an identification task on the same stimuli. The results showed that native English participants were more sensitive to reductions in aspiration than native Dutch participants, as indicated by shifts in the category boundary, by differing within-group patterns of mismatch-negativity responses, and by larger mean evoked potential amplitudes in the native English group for two of the three deviant stimuli. This between-group difference in the sensorineural processing of aspiration cues indicates that native language experience alters the way in which the acoustic features of speech are processed in the auditory brain, even following extensive second-language training.

Abstract

The adverb now in English (nu in Dutch) can draw listeners’ attention to an upcoming contrast (e.g., ‘Put X in Y. Now put X in Z’). In Dutch, but not English, the position of this sequential adverb may disambiguate which constituent is contrasted. We investigated whether and how the intonational realization of now/nu is varied to signal different scopes and whether it interacts with word order. Three contrast conditions (contrast in object, location, or both) were produced by eight Dutch and eight English speakers. Results showed no consistent use of word order for scope disambiguation in Dutch. Importantly, independent of language, an unaccented now/nu signaled a contrasting object while an accented now/nu signaled a contrast in the location. Since these intonational patterns were independent of word order, we interpreted the results in the framework of grammatical saliency: now/nu appears to be unmarked when the contrast lies in a salient constituent (the object) but marked with a prominent rise when a less salient constituent is contrasted (the location).

Abstract

INTRODUCTION It is nowadays well established that spoken sentence processing is achieved in an incremental manner. As a sentence unfolds over time, listeners rapidly process incoming information to eliminate local ambiguity and make predictions on the most plausible interpretation of the sentence. Previous research has shown that these predictions are based on all kinds of linguistic information, explicitly or implicitly in combination with world knowledge.1 A substantial amount of evidence comes from studies on online referential processing conducted in the visual-world paradigm (Cooper 1974; Eberhard, Spivey-Knowlton, Sedivy, and Tanenhaus 1995; Tanenhaus, Sedivy- Knowlton, Eberhard, and Sedivy 1995; Sedivy, Tanenhaus, Chambers, Carlson 1999).

Abstract

Sentences with a contrastive intonation contour are usually produced when the speaker entertains alternatives to the accented words. However, such contrastive sentences are frequently produced without making the alternatives explicit for the listener. In two cross-modal associative priming experiments we tested in Dutch whether such contextual alternatives become available to listeners upon hearing a sentence with a contrastive intonation contour compared with a sentence with a non-contrastive one. The first experiment tested the recognition of contrastive associates (contextual alternatives to the sentence-final primes), the second one the recognition of non-contrastive associates (generic associates which are not alternatives). Results showed that contrastive associates were facilitated when the primes occurred in sentences with a contrastive intonation contour but not in sentences with a non-contrastive intonation. Non-contrastive associates were weakly facilitated independent of intonation. Possibly, contrastive contours trigger an accommodation mechanism by which listeners retrieve the contrast available for the speaker.

Abstract

Sentences with a contrastive intonation contour are usually produced when the speaker entertains alternatives to the accented words. However, such contrastive sentences are frequently produced without making the alternatives explicit for the listener. In two cross-modal associative priming experiments we tested in Dutch whether such contextual alternatives become available to listeners upon hearing a sentence with a contrastive intonation contour compared with a sentence with a non-contrastive one. The first experiment tested the recognition of contrastive associates (contextual alternatives to the sentence-final primes), the second one the recognition of non-contrastive associates (generic associates which are not alternatives). Results showed that contrastive associates were facilitated when the primes occurred in sentences with a contrastive intonation contour but not in sentences with a non-contrastive intonation. Non-contrastive associates were weakly facilitated independent of intonation. Possibly, contrastive contours trigger an accommodation mechanism by which listeners retrieve the contrast available for the speaker.

Abstract

Both notional and grammatical number affect agreement during language production. To explore their workings, we investigated how semantic integration, a type of conceptual relatedness, produces variations in agreement (Solomon & Pearlmutter, 2004). These agreement variations are open to competing notional and lexical–grammatical number accounts. The notional hypothesis is that changes in number agreement reflect differences in referential coherence: More coherence yields more singularity. The lexical–grammatical hypothesis is that changes in agreement arise from competition between nouns differing in grammatical number: More competition yields more plurality. These hypotheses make opposing predictions about semantic integration. On the notional hypothesis, semantic integration promotes singular agreement. On the lexical–grammatical hypothesis, semantic integration promotes plural agreement. We tested these hypotheses with agreement elicitation tasks in two experiments. Both experiments supported the notional hypothesis, with semantic integration creating faster and more frequent singular agreement. This implies that referential coherence mediates the effect of semantic integration on number agreement.

Abstract

We describe our computer-supported framework to overcome the rule of metadata schism. It combines the use of controlled vocabularies, managed by a data category registry, with a component-based approach, where the categories can be combined to yield complex metadata structures. A metadata scheme devised in this way will thus be grounded in its use of categories. Schema designers will profit from existing prefabricated larger building blocks, motivating re-use at a larger scale. The common base of any two metadata schemes within this framework will solve, at least to a good extent, the semantic interoperability problem, and consequently, further promote systematic use of metadata for existing resources and tools to be shared.

Abstract

Although the possibility of referring or citing on-line data from publications is seen at least theoretically as an important means to provide immediate testable proof or simple illustration of a line of reasoning, the practice has not been wide-spread yet and no extensive experience has been gained about the possibilities and problems of referring to raw data-sets. This paper makes a case to investigate the possibility and need of persistent data visualization services that facilitate the inspection and evaluation of the cited data.

Abstract

This paper describes the status of the standardization efforts of a Component Metadata approach for describing Language Resources with metadata. Different linguistic and Language & Technology communities as CLARIN, META-SHARE and NaLiDa use this component approach and see its standardization of as a matter for cooperation that has the possibility to create a large interoperable domain of joint metadata. Starting with an overview of the component metadata approach together with the related semantic interoperability tools and services as the ISOcat data category registry and the relation registry we explain the standardization plan and efforts for component metadata within ISO TC37/SC4. Finally, we present information about uptake and plans of the use of component metadata within the three mentioned linguistic and L&T communities.

Abstract

This study investigates how inaccurate phoneme processing affects recognition of partially onset-overlapping pairs like DAFFOdil-DEFIcit and of minimal pairs like flash-flesh in second-language listening. Two cross-modal priming experiments examined differences between native (L1) and second-language (L2) listeners at two stages of lexical processing: first, the activation of intended and mismatching lexical representations and second, the competition between those lexical representations. Experiment 1 shows that truncated primes like daffo- and defi- activated lexical representations of mismatching words (either deficit or daffodil) more for L2 listeners than for L1 listeners. Experiment 2 shows that for minimal pairs, matching primes (prime: flash, target: FLASH) facilitated recognition of visual targets for L1 and L2 listeners alike, whereas mismatching primes (flesh, FLASH) inhibited recognition consistently for L1 listeners but only in a minority of cases for L2 listeners; in most cases, for them, primes facilitated recognition of both words equally strongly. Thus, L1 and L2 listeners' results differed both at the stages of lexical activation and competition. First, perceptually difficult phonemes activated mismatching words more for L2 listeners than for L1 listeners, and second, lexical competition led to efficient inhibition of mismatching competitors for L1 listeners but in most cases not for L2 listeners.

Abstract

Unlike most of the world's languages, Korean distinguishes three types of voiceless stops, namely lenis, fortis, and aspirated stops. All occur at three places of articulation. In previous work, acoustic measurements are mostly collapsed over the three places of articulation. This study therefore provides acoustic measurements of Korean lenis, fortis, and aspirated stops at all three places of articulation separately. Clear differences are found among the acoustic characteristics of the stops at the different places of articulation

Abstract

This study investigates the lexical representation of second-language words that contain difficult to distinguish phonemes. Dutch and English listeners' perception of partially onset-overlapping word pairs like DAFFOdil-DEFIcit and minimal pairs like flash-flesh, was assessed with two cross-modal priming experiments, examining two stages of lexical processing: activation of intended and mismatching lexical representations (Exp.1) and competition between those lexical representations (Exp.2). Exp.1 shows that truncated primes like daffo- and defi- activated lexical representations of mismatching words (either deficit or daffodil) more for L2 than L1 listeners. Exp.2 shows that for minimal pairs, matching primes (prime: flash, target: FLASH) facilitated recognition of visual targets for L1 and L2 listeners alike, whereas mismatching primes (flesh, FLASH) inhibited recognition consistently for L1 listeners but only in a minority of cases for L2 listeners; in most cases, for them, primes facilitated recognition of both words equally strongly. Importantly, all listeners experienced a combination of facilitation and inhibition (and all items sometimes caused facilitation and sometimes inhibition). These results suggest that for all participants, some of the minimal pairs were represented with separate, native-like lexical representations, whereas other pairs were stored as homophones. The nature of the L2 lexical representations thus varied strongly even within listeners.

Abstract

This paper shows that the effect of different types of noise on recognition of different phonemes by native versus non-native listeners is highly variable, even within classes of phonemes with the same manner or place of articulation. In a phoneme identification experiment, English and Dutch listeners heard all 24 English consonants in VCV stimuli in quiet and in three types of noise: competing talker, speech-shaped noise, and modulated speech-shaped noise (all with SNRs of −6 dB). Differential effects of noise type for English and Dutch listeners were found for eight consonants (/p t k g m n ŋ r/) but not for the other 16 consonants. For those eight consonants, effects were again highly variable: each noise type hindered non-native listeners more than native listeners for some of the target sounds, but none of the noise types did so for all of the target sounds, not even for phonemes with the same manner or place of articulation. The results imply that the noise types employed will strongly affect the outcomes of any study of native and non-native speech perception in noise.

Abstract

We investigated the extent to which emotionally valenced words automatically cue spatio-motor representations. Participants made speeded button presses, moving their hand upward or downward while viewing words with positive or negative valence. Only the color of the words was relevant to the response; on target trials, there was no requirement to read the words or process their meaning. In Experiment 1, upward responses were faster for positive words, and downward for negative words. This effect was extinguished, however, when words were repeated. In Experiment 2, participants performed the same primary task with the addition of distractor trials. Distractors either oriented attention toward the words’ meaning or toward their color. Congruity effects were increased with orientation to meaning, but eliminated with orientation to color. When people read words with emotional valence, vertical spatio-motor representations are activated highly automatically, but this automaticity is modulated by repetition and by attentional orientation to the words’ form or meaning.

Abstract

Background: According to decades of research on affective motivation in the human brain, approach motivational states are supported primarily by the left hemisphere and avoidance states by the right hemisphere. The underlying cause of this specialization, however, has remained unknown. Here we conducted a first test of the Sword and Shield Hypothesis (SSH), according to which the hemispheric laterality of affective motivation depends on the laterality of motor control for the dominant hand (i.e., the "sword hand," used preferentially to perform approach actions) and the nondominant hand (i.e., the "shield hand," used preferentially to perform avoidance actions). Methodology/Principal Findings: To determine whether the laterality of approach motivation varies with handedness, we measured alpha-band power (an inverse index of neural activity) in right- and left-handers during resting-state electroencephalography and analyzed hemispheric alpha-power asymmetries as a function of the participants' trait approach motivational tendencies. Stronger approach motivation was associated with more left-hemisphere activity in right-handers, but with more right-hemisphere activity in left-handers. Conclusions: The hemispheric correlates of approach motivation reversed between right- and left-handers, consistent with the way they typically use their dominant and nondominant hands to perform approach and avoidance actions. In both right- and left-handers, approach motivation was lateralized to the same hemisphere that controls the dominant hand. This covariation between neural systems for action and emotion provides initial support for the SSH

Abstract

This study examined whether listeners align to reduced speech. Participants were asked to shadow sentences from a casual speech corpus containing canonical and reduced targets. Participants' productions showed alignment: durations of canonical targets were longer than durations of reduced targets; and participants often imitated the segment types (canonical versus reduced) in both targets. The effect sizes were similar to previous work on alignment. In addition, shadowed productions were overall longer in duration than the original stimuli and this effect was larger for reduced than canonical targets. A possible explanation for this finding is that listeners reconstruct canonical forms from reduced forms.

Abstract

Three eye-tracking experiments investigated how phonological reductions (e.g., ‘‘puter’’ for ‘‘computer’’) modulate phonological competition. Participants listened to sentences extracted from a pontaneous speech corpus and saw four printed words: a target (e.g., ‘‘computer’’), a competitor similar to the canonical form (e.g., ‘‘companion’’), one similar to the reduced form (e.g.,
‘‘pupil’’), and an unrelated distractor. In Experiment 1, we presented canonical and reduced forms in a syllabic and in a sentence context. Listeners directed
their attention to a similar degree to both competitors independent of the
target’s spoken form. In Experiment 2, we excluded reduced forms and
presented canonical forms only. In such a listening situation, participants
showed a clear preference for the ‘‘canonical form’’ competitor. In Experiment 3, we presented canonical forms intermixed with reduced forms in a sentence context and replicated the competition pattern of Experiment 1. These data suggest that listeners penalize acoustic mismatches less strongly when listeningto reduced speech than when listening to fully articulated speech. We conclude
that flexibility to adjust to speech-intrinsic factors is a key feature of the spoken word recognition system.

Abstract

Previous research has shown that talker variability affects recognition memory for spoken words (Palmeri et al., 1993). This study examines whether additive noise is similarly retained in memory for spoken words. In a continuous recognition memory task, participants listened to a list of spoken words mixed with noise consisting of a pure tone or of high-pass filtered white noise. The noise and speech were in non-overlapping frequency bands. In Experiment 1, listeners indicated whether each spoken word in the list was OLD (heard before in the list) or NEW. Results showed that listeners were as accurate and as fast at recognizing a word as old if it was repeated with the same or different noise. In Experiment 2, listeners also indicated whether words judged as OLD were repeated with the same or with a different type of noise. Results showed that listeners benefitted from hearing words presented with the same versus different noise. These data suggest that spoken words and temporally-overlapping but spectrally non-overlapping noise are retained or reconstructed together for explicit, but not for implicit recognition memory. This indicates that the extent to which noise variability is retained seems to depend on the depth of processing

Abstract

In two eye-tracking experiments we examined whether wider discourse information helps
the recognition of reduced pronunciations (e.g., 'puter') more than the recognition of
canonical pronunciations of spoken words (e.g., 'computer'). Dutch participants listened to
sentences from a casual speech corpus containing canonical and reduced target words. Target
word recognition was assessed by measuring eye fixation proportions to four printed words
on a visual display: the target, a "reduced form" competitor, a "canonical form" competitor
and an unrelated distractor. Target sentences were presented in isolation or with a wider
discourse context. Experiment 1 revealed that target recognition was facilitated by wider
discourse information. Importantly, the recognition of reduced forms improved significantly
when preceded by strongly rather than by weakly supportive discourse contexts. This was not
the case for canonical forms: listeners' target word recognition was not dependent on the
degree of supportive context. Experiment 2 showed that the differential context effects in
Experiment 1 were not due to an additional amount of speaker information. Thus, these data
suggest that in natural settings a strongly supportive discourse context is more important for
the recognition of reduced forms than the recognition of canonical forms.

Abstract

In listeners' daily communicative exchanges, they most often hear casual speech, in which words are often produced with fewer segments, rather than the careful speech used in most psycholinguistic experiments. Three experiments examined phonological competition during the recognition of reduced forms such as [pjutər] for computer using a target-absent variant of the visual world paradigm. Listeners' eye movements were tracked upon hearing canonical and reduced forms as they looked at displays of four printed words. One of the words was phonologically similar to the canonical pronunciation of the target word, one word was similar to the reduced pronunciation, and two words served as unrelated distractors. When spoken targets were presented in isolation (Experiment 1) and in sentential contexts (Experiment 2), competition was modulated as a function of the target word form. When reduced targets were presented in sentential contexts, listeners were probabilistically more likely to first fixate reduced-form competitors before shifting their eye gaze to canonical-form competitors. Experiment 3, in which the original /p/ from [pjutər] was replaced with a “real” onset /p/, showed an effect of cross-splicing in the late time window. We conjecture that these results fit best with the notion that speech reductions initially activate competitors that are similar to the phonological surface form of the reduction, but that listeners nevertheless can exploit fine phonetic detail to reconstruct strongly reduced forms to their canonical counterparts.

Abstract

In traditional theories of language comprehension, syntactic and semantic processing are inextricably linked. This assumption has been challenged by the ‘Semantic Illusion Effect’ found in studies using Event Related brain Potentials. Semantically anomalous sentences did not produce the expected increase in N400 amplitude but rather one in P600 amplitude. To explain these findings, complex models have been devised in which an independent semantic processing stream can arrive at a sentence interpretation that may differ from the interpretation prescribed by the syntactic structure of the sentence. We review five such multi-stream models and argue that they do not account for the full range of relevant results because they assume that the amplitude of the N400 indexes some form of semantic integration. Based on recent evidence we argue that N400 amplitude might reflect the retrieval of lexical information from memory. On this view, the absence of an N400-effect in Semantic Illusion sentences can be explained in terms of priming. Furthermore, we suggest that semantic integration, which has previously been linked to the N400 component, might be reflected in the P600 instead. When combined, these functional interpretations result in a single-stream account of language processing that can explain all of the Semantic Illusion data.

Abstract

This paper investigates whether surprisal theory can account for differential processing difficulty in the NP-/S-coordination ambiguity in Dutch. Surprisal is estimated using a Probabilistic Context-Free Grammar (PCFG), which is induced from an automatically annotated corpus. We find that our lexicalized surprisal model can account for the reading time data from a classic experiment on this ambiguity by Frazier (1987). We argue that syntactic and lexical probabilities, as specified in a PCFG, are sufficient to account for what is commonly referred to as an NP-coordination preference.

Abstract

This study examined whether speech-on-speech masking is sensitive to variation in the degree of similarity between the target and the masker speech. Three experiments investigated whether speech-in-speech recognition varies across different background speech languages (English vs Dutch) for both English and Dutch targets, as well as across variation in the semantic content of the background speech (meaningful vs semantically anomalous sentences), and across variation in listener status vis-à-vis the target and masker languages (native, non-native, or unfamiliar). The results showed that the more similar the target speech is to the masker speech (e.g., same vs different language, same vs different levels of semantic content), the greater the interference on speech recognition accuracy. Moreover, the listener’s knowledge of the target and the background language modulate the size of the release from masking. These factors had an especially strong effect on masking effectiveness in highly unfavorable listening conditions. Overall this research provided evidence that that the degree of target-masker similarity plays a significant role in speech-in-speech recognition. The results also give insight into how listeners assign their resources differently depending on whether they are listening to their first or second language

Abstract

How are events framed in narrative? Speakers of English (a 'satellite-framed' language), when 'reading' Mercer Mayer's wordless picture book 'Frog, Where Are You?', find the story self-evident: a boy has a dog and a pet frog; the frog escapes and runs away; the boy and dog look for it across hill and dale, through woods and over a cliff, until they find it and return home with a baby frog child of the original pet frog. In Tzeltal, as spoken in a Mayan community in southern Mexico, the story is somewhat different, because the language structures event descriptions differently. Tzeltal is in part a 'verb-framed' language with a set of Path-encoding motion verbs, so that the bare bones of the Frog story can consist of verbs translating as 'go'/'pass by'/'ascend'/ 'descend'/ 'arrive'/'return'. But Tzeltal also has satellite-framing adverbials, grammaticized from the same set of motion verbs, which encode the direction of motion or the orientation of static arrays. Furthermore, motion is not generally encoded barebones, but vivid pictorial detail is provided by positional verbs which can describe the position of the Figure as an outcome of a motion event; motion and stasis are thereby combined in a single event description. (For example: jipot jawal "he has been thrown (by the deer) lying¬_face_upwards_spread-eagled". This paper compares the use of these three linguistic resources in frog narratives from 14 Tzeltal adults and 21 children, looks at their development in the narratives of children between the ages of 4-12, and considers the results in relation to those from Berman and Slobin's (1996) comparative study of adult and child Frog stories.

Abstract

Languages vary typologically in their lexicalization of Path of motion (Talmy 1991). Furthermore, lexicalization patterns are argued to affect syntactic packaging at the level of the clause (e.g. Slobin 1996b) and tend to transfer from a first (L1) to a second language (L2) in second language acquisition (e.g. Cadierno 2004). From this crosslinguistic and developmental evidence, typological preferences for Path expression appear highly robust features of a first language. The current study examines the extent to which preferences for Path encoding really are as enduring as they seem by investigating (1) whether Japanese follows patterns identified for other verb-framed languages like Spanish, and (2) whether patterns established in one’s first language can change after acquisition of a second language. L1 performance of native speakers of Japanese with intermediate-level knowledge of English was compared to that of monolingual speakers of Japanese and English. Results showed that monolingual Japanese speakers followed basic lexicalization patterns typical of other verb-framed languages, but with different realizations of Path packaging within the clause. Moreover, non-monolingual Japanese speakers displayed both English- and Japanese-like patterns for lexicalization with significantly more Path information per clause than either group of monolinguals. Implications for typology and second language acquisition are discussed.

Abstract

This is an encyclopedia entry surveying anthropological approaches to cognition and culture.

Abstract

This is a reprint of the Brown and Levinson 2000 article.

Abstract

This task has two parts: (i) video-taped elicitation of the range of possibilities for referring to persons and places, and (ii) observations of (first) references to persons and places in video-taped natural interaction. The goal of this task is to establish the repertoires of referential terms (and other practices) used for referring to persons and to places in particular languages and cultures, and provide examples of situated use of these kinds of referential practices in natural conversation. This data will form the basis for cross-language comparison, and for formulating hypotheses about general principles underlying the deployment of such referential terms in natural language usage.

Abstract

This work was supported by the Max Planck Institute for Psycholinguistics and the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO; MPI 56-384, The Dynamics of Multilingual Processing, awarded to M Gullberg and P Indefrey).

Abstract

Interaction, for all that it has an ethological base, is culturally constituted, and how new social members are enculturated into the interactional practices of the society is of critical interest to our understanding of interaction – how much is learned, how variable is it across cultures – as well as to our understanding of the role of culture in children’s social-cognitive development. The goal of this task is to document the nature of caregiver infant interaction in different cultures, especially during the critical age of 9-15 months when children come to have an understanding of others’ intentions. This is of interest to all students of interaction; it does not require specialist knowledge of children.

Abstract

This research received technical and financial support from Syracuse University, the Max Planck Institute for Psycholinguistics, and the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO; MPI 56-384, The Dynamics of Multilingual Processing, awarded to Marianne Gullberg and Peter Indefrey).

Abstract

This is a translation of the Brown 1998 article in Journal of Linguistic Anthropology, 'Conversational structure and language acquisition: The role of repetition in Tzeltal adult and child speech'.

Abstract

This paper reports the results of a study of Tzeltal questions and their responses, based on a collection of 419 question/response sequences drawn from video recordings of ‘maximally casual’ naturally occurring face-to-face interactions in a Tzeltal (Mayan) community. I describe the lexical and grammatical resources for formulating content and polar questions in Tzeltal, the different kinds of social actions that questions can be used to perform and their relative frequency in the data, and the characteristic properties of responses to questions. This is part of a large-scale comparative study of questions in 10 different languages, and we find that Tzeltal is like most others in making much more use of polar than of content questions, and in the strong tendency for confirming answers to polar questions. Tzeltal is however unusual in three respects: in the comparatively minimal use of gaze to select next speaker, in the frequency with which answers take the form of repeats, and in the complete absence of visible-only responses (e.g., nods or head-shakes). There are also some language-specific properties of question–answer sequences that reveal cultural shaping of sequencing in conversation.

Abstract

This paper presents results of a comparative project documenting the development of verbal agreement inflections in children learning four different Mayan languages: K’iche’, Tzeltal, Tzotzil, and Yukatek. These languages have similar inflectional paradigms: they have a generally agglutinative morphology, with transitive verbs obligatorily marked with separate cross-referencing inflections for the two core arguments (‘ergative’ and ‘absolutive’). Verbs are also inflected for aspect and mood, and they carry a ‘status suffix’ which generally marks verb transitivity and mood. At a more detailed level, the four languages differ strikingly in the realization of cross-reference marking. For each language, we examined longitudinal language production data from two children at around 2;0, 2;6, 3;0, and 3;6 years of age. We relate differences in the acquisition patterns of verbal morphology in the languages to 1) the placement of affixes, 2) phonological and prosodic prominence, 3) language-specific constraints on the various forms of the affixes, and 4) consistent vs. split ergativity, and conclude that prosodic salience accounts provide th ebest explanation for the acquisition patterns in these four languages.

Abstract

In this paper I take up the idea that human thinking is systematically biased in the direction of interactive thinking (E. Goody's anticipatory interactive planning), that is, that humans are peculiarly good at, and inordinately prone to, attributing intentions and goals to one other (as well as to non-humans), and that they routinely orient to presumptions about each other's intentions in what they say and do. I explore the implications of that idea for an understanding of politeness in interaction, taking as a starting point the Brown and Levinson (1987) model of politeness, which assumes interactive thinking, a notion implicit in the formulation of politeness as strategic orientation to face. Drawing on an analysis of the phenomenon of conventionalized ‘irony’ in Tzeltal, I emphasize that politeness does not inhere in linguistic form per se but is a matter of conveying a polite intention, and argue that Tzeltal irony provides a prime example of one way in which humans' highly-developed intellectual machinery for inferring alter's intentions is put to the service of social relationships.

Abstract

Linguistic expressions of time often draw on spatial language, which raises the question of whether cultural specificity in spatial language and cognition is reflected in thinking about time. In the Mayan language Tzeltal, spatial language relies heavily on an absolute frame of reference utilizing the overall slope of the land, distinguishing an “uphill/downhill” axis oriented from south to north, and an orthogonal “crossways” axis (sunrise-set) on the basis of which objects at all scales are located. Does this absolute system for calculating spa-tial relations carry over into construals of temporal relations? This question was explored in a study where Tzeltal consultants produced temporal expressions and performed two different non-linguistic temporal ordering tasks. The results show that at least five distinct schemata for conceptualizing time underlie Tzeltal linguistic expressions: (i) deictic ego-centered time, (ii) time as an ordered sequence (e.g., “first”/“later”), (iii) cyclic time (times of the day, seasons), (iv) time as spatial extension or location (e.g., “entering/exiting July”), and (v) a time vector extending uphillwards into the future. The non-linguistic task results showed that the “time moves uphillwards” metaphor, based on the absolute frame of reference prevalent in Tzeltal spatial language and thinking and important as well in the linguistic expressions for time, is not strongly reflected in responses on these tasks. It is argued that systematic and consistent use of spatial language in an absolute frame of reference does not necessarily transfer to consistent absolute time conceptualization in non-linguistic tasks; time appears to be more open to alternative construals.

Abstract

This paper examines the verbs and other spatial vocabulary used for describing events of ‘putting’ and ‘taking’ in Tzeltal (Mayan). I discuss the semantics of different ‘put’ and ‘take’ verbs, the constructions they occur in, and the extensional patterns of verbs used in ‘put’ (Goal-oriented) vs. ‘take’ (Source-oriented) descriptions. A relatively limited role for semantically general verbs was found. Instead, Tzeltal is a ‘multiverb language’ with many different verbs usable to predicate ‘put’ and ‘take’ events, with verb choice largely determined by the shape, orientation, and resulting disposition of the Figure and Ground objects. The asymmetry that has been observed in other languages, with Goal-oriented ‘put’ verbs more finely distinguished lexically than Source-oriented ‘take’ verbs, is also apparent in Tzeltal.

Abstract

This is a Spanish translation of Brown 2002, 'Everyone has to lie in Tzeltal'. Translated by B. E. Alvaraz Klein

Abstract

This study is about the principles for constructing polite speech. We describe and account for some remarkable parallelisms in the linguistic construction of utterances with which people express themselves in different languges and cultures. A motive for these parallels is isolated - politeness, broadly defined to include both polite friendliness and polite formality - and a universal model is constructed outlining the abstract principles underlying polite usages. This is based on the detailed study of three unrelated languages and cultures: the Tamil of south India, the Tzeltal spoken by Mayan Indians in Chiapas, Mexico, and the English of the USA and England, supplemented by examples from other cultures. Of general interest is the point that underneaath the apparent diversity of polite behaviour in different societies lie some general pan-human principles of social interaction, and the model of politenss provides a tool for analysing the quality of social relations in any society.

Abstract

The Hmong Diaspora is one of the widest modern human migrations. Mainly localised in South-East Asia, the United States of America, and metropolitan France, a small community has also settled the Amazonian forest of French Guiana. We have biologically analysed 62 individuals of this unique Guianese population through three complementary genetic markers: mitochondrial DNA (HVS-I/II and coding region SNPs), Y-chromosome (SNPs and STRs), and the Gm allotypic system. All genetic systems showed a high conservation of the Asian gene pool (Asian ancestry: mtDNA = 100.0%; NRY = 99.1%; Gm = 96.6%), without a trace of founder effect. When compared across various Asian populations, the highest correlations were observed with Hmong-Mien groups still living in South-East Asia (Fst < 0.05; P-value < 0.05). Despite a long history punctuated by exodus, the French Guianese Hmong have maintained their original genetic diversity.

Abstract

Background Retracing the genetic histories of the descendant populations of the Slave Trade (16th-19th centuries) is particularly challenging due to the diversity of African ethnic groups involved and the different hybridisation processes with Europeans and Amerindians, which have blurred their original genetic inheritances. The Noir Marron in French Guiana are the direct descendants of maroons who escaped from Dutch plantations in the current day Surinam. They represent an original ethnic group with a highly blended culture. Uniparental markers (mtDNA and NRY) coupled with HTLV-1 sequences (env and LTR) were studied to establish the genetic relationships linking them to African American and African populations. Results All genetic systems presented a high conservation of the African gene pool (African ancestry: mtDNA = 99.3%; NRY = 97.6%; HTLV-1 env = 20/23; HTLV-1 LTR = 6/8). Neither founder effect nor genetic drift was detected and the genetic diversity is within a range commonly observed in Africa. Higher genetic similarities were observed with the populations inhabiting the Bight of Benin (from Ivory Coast to Benin). Other ancestries were identified but they presented an interesting sex-bias. Whilst male origins spread throughout the north of the bight (from Benin to Senegal), female origins were spread throughout the south (from the Ivory Coast to Angola). Conclusions The Noir Marron are unique in having conserved their African genetic ancestry, despite major cultural exchanges with Amerindians and Europeans through inhabiting the same region for four centuries. Their maroon identity and the important number of slaves deported in this region have maintained the original African diversity. All these characteristics permit to identify a major origin located in the former region of the Gold Coast and the Bight of Benin; regions highly impacted by slavery, from which goes a sex-biased longitudinal gradient of ancestry.

Abstract

We investigated localization performance of simple targets in patient TN, who suffered bilateral damage of his primary visual cortex and shows complete cortical blindness. Using a two-alternative forced-choice paradigm, TN was asked to guess the position of left-right targets with goal-directed and discrete manual responses. The results indicate a clear dissociation between goal-directed and discrete responses. TN pointed toward the correct target location in approximately 75% of the trials but was at chance level with discrete responses. This indicates that the residual ability to localize an unseen stimulus depends critically on the possibility to translate a visual signal into a goal-directed motor output at least in certain forms of blindsight.

Abstract

The recently disclosed plasticity properties of adult-derived stem cells, their ability to be reprogrammed by defined factors into pluripotent stem cells and the comprehension of “epi”-genetic mechanisms underlying stem cells differentiation process has opened unexpected avenues to attempt regeneration of tissues affected by degenerative disorders and prompted the birth of the new “regenerative medicine” concept. Regeneration of the vascular and myocardial tissues is considered a primary endpoint to limit the consequences of acute and chronic ischemic heart disorders. Cellular therapy of the ischemic heart has been attempted in more than 1000 patients worldwide and the results of the first meta-analysis studies have been recently made available. In several cases, the results did not fulfill the expectations. In fact, they unpredictably indicated modest, yet significant, clinical benefits in patients compared to the outstanding results using stem cells in animal models of ischemic heart and peripheral disease. Several interpretations have been raised to explain these discrepancies. These include lifestyle and risk factor-associated modifications of the stem cell biological activity, but also procedural problems in the translation of cells from bench to bedside. The present review will cover light and shaded areas in the cardiovascular cellular therapy field, and will discuss about recent advances and related patents designed to enhance efficiency of stem cell therapy in patients with cardiovascular disease. These advancements will be discussed in the light of the most advanced issues that have been introduced worldwide by Regulatory Agencies. - See more at: http://www.eurekaselect.com/85525/article#sthash.lEuaE1A5.dpuf

Abstract

This paper explores the linguistic encoding of placement and removal events in Jahai (Austroasiatic, Malay Peninsula) on the basis of descriptions from a video elicitation task. It outlines the structural characteristics of the descriptions and isolates semantically a set of situation types that find expression in lexical opposites: (1) putting/taking, (2) inserting/extracting, (3) dressing/undressing, and (4) placing/removing one’s body parts. All involve deliberate and controlled placing/removing of a solid Figure object in relation to a Ground which is not a human recipient. However, they differ as to the identity of and physical relationship between Figure and Ground. The data also provide evidence of variation in how semantic roles are mapped onto syntactic constituents: in most situation types, Agent, Figure and Ground associate with particular constituent NPs, but some placement events are described with semantically specialised verbs encoding the Figure and even the Ground.

Abstract

This study examines whether the production of words with two phonological variants involves single or multiple lexical phonological representations. Three production experiments investigated the roles of the relative frequencies of the two pronunciation variants of French words with schwa: the schwa variant (e.g., Image ) and the reduced variant (e.g., Image ). In two naming tasks and in a symbol–word association learning task, variants with higher relative frequencies were produced faster. This suggests that the production lexicon keeps a frequency count for each variant and hence that schwa words are represented in the production lexicon with two different lexemes. In addition, the advantage for schwa variants over reduced variants in the naming tasks but not in the learning task and the absence of a variant relative frequency effect for schwa variants produced in isolation support the hypothesis that context affects the variants’ lexical activation and modulates the effect of variant relative frequency.

Abstract

Cortical blindness refers to the loss of vision that occurs after destruction of the primary visual cortex. Although there is no sensory cortex and hence no conscious vision, some cortically blind patients show amygdala activation in response to facial or bodily expressions of emotion. Here we investigated whether direction of gaze could also be processed in the absence of any functional visual cortex. A well-known patient with bilateral destruction of his visual cortex and subsequent cortical blindness was investigated in an fMRI paradigm during which blocks of faces were presented either with their gaze directed toward or away from the viewer. Increased right amygdala activation was found in response to directed compared with averted gaze. Activity in this region was further found to be functionally connected to a larger network associated with face and gaze processing. The present study demonstrates that, in human subjects, the amygdala response to eye contact does not require an intact primary visual cortex.

Abstract

Nuclear receptors (NRs) form a large superfamily of transcription factors that participate in virtually every key biological process. They control development, fertility, gametogenesis and are misregulated in many cancers. Their enormous functional plasticity as transcription factors relates in part to NR-mediated interactions with hundreds of coregulatory proteins upon ligand (e.g., hormone) binding to their ligand binding domains (LBD), or following covalent modification. Some coregulator association relates to the distinct residues that shape a coactivator binding pocket termed AF-2, a surface groove that primarily determines the preference and specificity of protein–protein interactions. However, the highly conserved AF-2 pocket in the NR superfamily appears to be insufficient to account for NR subtype specificity leading to fine transcriptional modulation in certain settings. Additional protein–protein interaction surfaces, most notably on their LBD, may contribute to modulating NR function. NR coregulators and chaperones, normally much larger than the NR itself, may also bind to such interfaces. In the case of the androgen receptor (AR) LBD surface, structural and functional data highlighted the presence of another site named BF-3, which lies at a distinct but topographically adjacent surface to AF-2. AR BF-3 is a hot spot for mutations involved in prostate cancer and androgen insensitivity syndromes, and some FDA-approved drugs bind at this site. Structural studies suggested an allosteric relationship between AF-2 and BF-3, as occupancy of the latter affected coactivator recruitment to AF-2. Physiological relevant partners of AR BF-3 have not been described as yet. The newly discovered site is highly conserved among the steroid receptors subclass, but is also present in other NRs. Several missense mutations in the BF-3 regions of these human NRs are implicated in pathology and affect their function in vitro. The fact that AR BF-3 pocket is a druggable site evidences its pharmacological potential. Compounds that may affect allosterically NR function by binding to BF-3 open promising avenues to develop type-specific NR modulators.

Abstract

Much evidence has suggested that people conceive of time as flowing directionally in transverse space (e.g., from left to right for English speakers). However, this phenomenon has never been tested in a fully nonlinguistic paradigm where neither stimuli nor task use linguistic labels, which raises the possibility that time is directional only when reading/writing direction has been evoked. In the present study, English-speaking participants viewed a video where an actor sang a note while gesturing and reproduced the duration of the sung note by pressing a button. Results showed that the perceived duration of the note was increased by a long-distance gesture, relative to a short-distance gesture. This effect was equally strong for gestures moving from left to right and from right to left and was not dependent on gestures depicting movement through space; a weaker version of the effect emerged with static gestures depicting spatial distance. Since both our gesture stimuli and temporal reproduction task were nonlinguistic, we conclude that the spatial representation of time is nondirectional: Movement contributes, but is not necessary, to the representation of temporal information in a transverse timeline.

Abstract

Purpose: To investigate masking release for speech maskers for linguistically and phonetically close (English and Dutch) and distant (English and Mandarin) language pairs. Method: Thirty-two monolingual speakers of English with normal audiometric thresholds participated in the study. Data are reported for an English sentence recognition task in English and for Dutch and Mandarin competing speech maskers (Experiment 1) and noise maskers (Experiment 2) that were matched either to the long-term average speech spectra or to the temporal modulations of the speech maskers from Experiment 1. Results: Listener performance increased as the target-tomasker linguistic distance increased (English-in-English < English-in-Dutch < English-in-Mandarin). Conclusion: Spectral differences between maskers can account for some, but not all, of the variation in performance between maskers; however, temporal differences did not seem to play a significant role.

Abstract

Humans are the only species that uses communication to teach new knowledge to novices, usually to children (Tomasello, 1999 and Csibra and Gergely, 2006). This context of communication can employ “demonstrations” and it takes place with or without the help of objects (Clark, 1996). Previous research has focused on understanding the nature of demonstrations for very young children and with objects involved. However, little is known about the strategies used in demonstrating an action to an older child in comparison to another adult and without the use of objects, i.e., with gestures only. We tested if during demonstration of an action speakers use different degrees of iconicity in gestures for a child compared to an adult. 18 Italian subjects described to a camera how to make coffee imagining the listener as a 12-year-old child, a novice or an expert adult. While speech was found more informative both for the novice adult and for the child compared to the expert adult, the rate of iconic gestures increased and they were more informative and bigger only for the child compared to both of the adult conditions. Iconicity in gestures can be a powerful communicative strategy in teaching new knowledge to children in demonstrations and this is in line with claims that it can be used as a scaffolding device in grounding knowledge in experience (Perniss et al., 2010).