Publications

Displaying 101 - 200 of 349
  • Harbusch, K., & Kempen, G. (2000). Complexity of linear order computation in Performance Grammar, TAG and HPSG. In Proceedings of Fifth International Workshop on Tree Adjoining Grammars and Related Formalisms (TAG+5) (pp. 101-106).

    Abstract

    This paper investigates the time and space complexity of word order computation in the psycholinguistically motivated grammar formalism of Performance Grammar (PG). In PG, the first stage of syntax assembly yields an unordered tree ('mobile') consisting of a hierarchy of lexical frames (lexically anchored elementary trees). Associated with each lexica l frame is a linearizer—a Finite-State Automaton that locally computes the left-to-right order of the branches of the frame. Linearization takes place after the promotion component may have raised certain constituents (e.g. Wh- or focused phrases) into the domain of lexical frames higher up in the syntactic mobile. We show that the worst-case time and space complexity of analyzing input strings of length n is O(n5) and O(n4), respectively. This result compares favorably with the time complexity of word-order computations in Tree Adjoining Grammar (TAG). A comparison with Head-Driven Phrase Structure Grammar (HPSG) reveals that PG yields a more declarative linearization method, provided that the FSA is rewritten as an equivalent regular expression.
  • Heeschen, V., Eibl-Eibesfeldt, I., Grammer, K., Schiefenhövel, W., & Senft, G. (1986). Sprachliches Verhalten. In Generalverwaltung der MPG (Ed.), Max-Planck-Gesellschaft Jahrbuch 1986 (pp. 394-396). Göttingen: Vandenhoeck and Ruprecht.
  • Hoppenbrouwers, G., Seuren, P. A. M., & Weijters, A. (Eds.). (1985). Meaning and the lexicon. Dordrecht: Foris.
  • Houston, D. M., Jusczyk, P. W., Kuijpers, C., Coolen, R., & Cutler, A. (2000). Cross-language word segmentation by 9-month-olds. Psychonomic Bulletin & Review, 7, 504-509.

    Abstract

    Dutch-learning and English-learning 9-month-olds were tested, using the Headturn Preference Procedure, for their ability to segment Dutch words with strong/weak stress patterns from fluent Dutch speech. This prosodic pattern is highly typical for words of both languages. The infants were familiarized with pairs of words and then tested on four passages, two that included the familiarized words and two that did not. Both the Dutch- and the English-learning infants gave evidence of segmenting the targets from the passages, to an equivalent degree. Thus, English-learning infants are able to extract words from fluent speech in a language that is phonetically different from English. We discuss the possibility that this cross-language segmentation ability is aided by the similarity of the typical rhythmic structure of Dutch and English words.
  • Indefrey, P., & Levelt, W. J. M. (2000). The neural correlates of language production. In M. S. Gazzaniga (Ed.), The new cognitive neurosciences; 2nd ed. (pp. 845-865). Cambridge, MA: MIT Press.

    Abstract

    This chapter reviews the findings of 58 word production experiments using different tasks and neuroimaging techniques. The reported cerebral activation sites are coded in a common anatomic reference system. Based on a functional model of language production, the different word production tasks are analyzed in terms of their processing components. This approach allows a distinction between the core process of word production and preceding task-specific processes (lead-in processes) such as visual or auditory stimulus recognition. The core process of word production is subserved by a left-lateralized perisylvian/thalamic language production network. Within this network there seems to be functional specialization for the processing stages of word production. In addition, this chapter includes a discussion of the available evidence on syntactic production, self-monitoring, and the time course of word production.
  • Ingvar, M., & Petersson, K. M. (2000). Functional maps and brain networks. In A. W. Toga (Ed.), Brain mapping: The systems (pp. 111-140). San Diego: Academic Press.
  • Janse, E., Sennema, A., & Slis, A. (2000). Fast speech timing in Dutch: The durational correlates of lexical stress and pitch accent. In Proceedings of the VIth International Conference on Spoken Language Processing, Vol. III (pp. 251-254).

    Abstract

    n this study we investigated the durational correlates of lexical stress and pitch accent at normal and fast speech rate in Dutch. Previous literature on English shows that durations of lexically unstressed vowels are reduced more than stressed vowels when speakers increase their speech rate. We found that the same holds for Dutch, irrespective of whether the unstressed vowel is schwa or a "full" vowel. In the same line, we expected that vowels in words without a pitch accent would be shortened relatively more than vowels in words with a pitch accent. This was not the case: if anything, the accented vowels were shortened relatively more than the unaccented vowels. We conclude that duration is an important cue for lexical stress, but not for pitch accent.
  • Janse, E. (2000). Intelligibility of time-compressed speech: Three ways of time-compression. In Proceedings of the VIth International Conference on Spoken Language Processing, vol. III (pp. 786-789).

    Abstract

    Studies on fast speech have shown that word-level timing of fast speech differs from that of normal rate speech in that unstressed syllables are shortened more than stressed syllables as speech rate increases. An earlier experiment showed that the intelligibility of time-compressed speech could not be improved by making its temporal organisation closer to natural fast speech. To test the hypothesis that segmental intelligibility is more important than prosodic timing in listening to timecompressed speech, the intelligibility of bisyllabic words was tested in three time-compression conditions: either stressed and unstressed syllable were compressed to the same degree, or the stressed syllable was compressed more than the unstressed syllable, or the reverse. As was found before, imitating wordlevel timing of fast speech did not improve intelligibility over linear compression. However, the results did not confirm the hypothesis either: there was no difference in intelligibility between the three compression conditions. We conclude that segmental intelligibility plays an important role, but further research is necessary to decide between the contributions of prosody and segmental intelligibility to the word-level intelligibility of time-compressed speech.
  • Janzen, G., Herrmann, T., Katz, S., & Schweizer, K. (2000). Oblique Angled Intersections and Barriers: Navigating through a Virtual Maze. In Spatial Cognition II (pp. 277-294). Berlin: Springer.

    Abstract

    The configuration of a spatial layout has a substantial effect on the acquisition and the representation of the environment. In four experiments, we investigated navigation difficulties arising at oblique angled intersections. In the first three studies we investigated specific arrow-fork configurations. In dependence on the branch subjects use to enter the intersection different decision latencies and numbers of errors arise. If subjects see the intersection as a fork, it is more difficult to find the correct way as if it is seen as an arrow. In a fourth study we investigated different heuristics people use while making a detour around a barrier. Detour behaviour varies with the perspective. If subjects learn and navigate through the maze in a field perspective they use a heuristic of preferring right angled paths. If they have a view from above and acquire their knowledge in an observer perspective they use oblique angled paths more often.

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  • Jaspers, D., Klooster, W., Putseys, Y., & Seuren, P. A. M. (Eds.). (1989). Sentential complementation and the lexicon: Studies in honour of Wim de Geest. Dordrecht: Foris.
  • Jesse, A., Vrignaud, N., Cohen, M. M., & Massaro, D. W. (2000). The processing of information from multiple sources in simultaneous interpreting. Interpreting, 5(2), 95-115. doi:10.1075/intp.5.2.04jes.

    Abstract

    Language processing is influenced by multiple sources of information. We examined whether the performance in simultaneous interpreting would be improved when providing two sources of information, the auditory speech as well as corresponding lip-movements, in comparison to presenting the auditory speech alone. Although there was an improvement in sentence recognition when presented with visible speech, there was no difference in performance between these two presentation conditions when bilinguals simultaneously interpreted from English to German or from English to Spanish. The reason why visual speech did not contribute to performance could be the presentation of the auditory signal without noise (Massaro, 1998). This hypothesis should be tested in the future. Furthermore, it should be investigated if an effect of visible speech can be found for other contexts, when visual information could provide cues for emotions, prosody, or syntax.
  • Johnson, E. K., Jusczyk, P. W., Cutler, A., & Norris, D. (2000). The development of word recognition: The use of the possible-word constraint by 12-month-olds. In L. Gleitman, & A. Joshi (Eds.), Proceedings of CogSci 2000 (pp. 1034). London: Erlbaum.
  • Jongen-Janner, E., Pijls, F., & Kempen, G. (1990). Intelligente programma's voor grammatica- en spellingonderwijs. In Q. De Kort, & G. Leerdam (Eds.), Computertoepassingen in de Neerlandistiek. Almere: Landelijke Vereniging van Neerlandici.
  • Kempen, G. (1986). Beyond word processing. In E. Cluff, & G. Bunting (Eds.), Information management yearbook 1986 (pp. 178-181). London: IDPM Publications.
  • Kempen, G. (1990). Een slordig gestapeld servies [Review of the book Tranen van de krokodil by Piet Vroon]. Intermediair, 26(17), 67-69.
  • Kempen, G., Schotel, H., & Hoenkamp, E. (1982). Analyse-door-synthese van Nederlandse zinnen [Abstract]. De Psycholoog, 17, 509.
  • Kempen, G. (1985). Artificiële intelligentie: Bouw, benutting, beheersing. In W. Veldkamp (Ed.), Innovatie in perspectief (pp. 42-47). Vianen: Nixdorf Computer B.V.
  • Kempen, G. (1973). [Review of the book Psycholinguïstiek by B. Tervoort et al.]. Nederlands Tijdschrift voor de Psychologie, 28, 172-174.
  • Kempen, G. (2000). Could grammatical encoding and grammatical decoding be subserved by the same processing module? Behavioral and Brain Sciences, 23, 38-39.
  • Kempen, G., & Hoenkamp, E. (1982). Incremental sentence generation: Implications for the structure of a syntactic processor. In J. Horecký (Ed.), COLING 82. Proceedings of the Ninth International Conference on Computational Linguistics, Prague, July 5-10, 1982 (pp. 151-156). Amsterdam: North-Holland.

    Abstract

    Human speakers often produce sentences incrementally. They can start speaking having in mind only a fragmentary idea of what they want to say, and while saying this they refine the contents underlying subsequent parts of the utterance. This capability imposes a number of constraints on the design of a syntactic processor. This paper explores these constraints and evaluates some recent computational sentence generators from the perspective of incremental production.
  • Kempen, G., & Vosse, T. (1989). Incremental syntactic tree formation in human sentence processing: A cognitive architecture based on activation decay and simulated annealing. Connection Science, 1(3), 273-290. doi:10.1080/09540098908915642.

    Abstract

    A new cognitive architecture is proposed for the syntactic aspects of human sentence processing. The architecture, called Unification Space, is biologically inspired but not based on neural nets. Instead it relies on biosynthesis as a basic metaphor. We use simulated annealing as an optimization technique which searches for the best configuration of isolated syntactic segments or subtrees in the final parse tree. The gradually decaying activation of individual syntactic nodes determines the ‘global excitation level’ of the system. This parameter serves the function of ‘computational temperature’ in simulated annealing. We have built a computer implementation of the architecture which simulates well-known sentence understanding phenomena. We report successful simulations of the psycholinguistic effects of clause embedding, minimal attachment, right association and lexical ambiguity. In addition, we simulated impaired sentence understanding as observable in agrammatic patients. Since the Unification Space allows for contextual (semantic and pragmatic) influences on the syntactic tree formation process, it belongs to the class of interactive sentence processing models.
  • Kempen, G. (1989). Informatiegedragskunde: Pijler van de moderne informatieverzorging. In A. F. Marks (Ed.), Sociaal-wetenschappelijke informatie en kennisvorming in onderzoek, onderzoeksbeleid en beroep (pp. 31-35). Amsterdam: SWIDOC.
  • Kempen, G. (1990). Microcomputers en cognitiewetenschap. SURF: Tijdschrift over Computerdienstverlening in het Hoger Onderwijs en Onderzoek, 4(3), 2.
  • Kempen, G., & Jongen-Janner, E. (1990). Naar een flexibele methode voor algoritmisch grammatica- en spellingonderwijs. Pedagogisch Tijdschrift, 15, 280-289.
  • Kempen, G. (1986). Kunstmatige intelligentie en gezond verstand. In P. Hagoort, & R. Maessen (Eds.), Geest, computer, kunst (pp. 118-123). Utrecht: Stichting Grafiet.
  • Kempen, G. (1989). Language generation systems. In I. S. Bátori, W. Lenders, & W. Putschke (Eds.), Computational linguistics: An international handbook on computer oriented language research and applications (pp. 471-480). Berlin/New York: Walter de Gruyter.
  • Kempen, G., & Kolk, H. (1986). Het voortbrengen van normale en agrammatische taal. Van Horen Zeggen, 27(2), 36-40.
  • Kempen, G. (1985). Psychologie 2000. Toegepaste psychologie in de informatiemaatschappij. Computers in de psychologie, 13-21.
  • Kempen, G., & Takens, R. (Eds.). (1986). Psychologie, informatica en informatisering. Lisse: Swets & Zeitlinger.
  • Kempen, G. (1990). Representation in memory: Volume 2, chapter 8, pp. 511–587 by David E. Rumelhart and Donald A. Norman [Book review]. Acta Psychologica, 75, 191-192. doi:10.1016/0001-6918(90)90107-Q.
  • Kempen, G. (1990). Taaltechnologie en de toekomst van tekstautomatisering. Informatie, 32, 724-727.
  • Kempen, G., Schotel, H., & Pijls, J. (1985). Taaltechnologie en taalonderwijs. In J. Heene (Ed.), Onderwijs en informatietechnologie. Den Haag: Stichting voor Onderzoek van het Onderwijs (SVO).
  • Kempen, G. (1986). RIKS: Kennistechnologisch centrum voor bedrijfsleven en wetenschap. Informatie, 28, 122-125.
  • Kilborn, K., & Weissenborn, J. (1989). Max-Planck-Institute for Psycholinguistics: Annual Report Nr.10 1989. Nijmegen: MPI for Psycholinguistics.
  • Klein, W. (2000). Changing concepts of the nature-nurture debate. In R. Hide, J. Mittelstrass, & W. Singer (Eds.), Changing concepts of nature at the turn of the millenium: Proceedings plenary session of the Pontifical academy of sciences, 26-29 October 1998 (pp. 289-299). Vatican City: Pontificia Academia Scientiarum.
  • Klein, W. (1990). A theory of language acquisition is not so easy. Studies in Second Language Acquisition, 12, 219-231. doi:10.1017/S0272263100009104.
  • Klein, W., & Rieck, B.-O. (1982). Der Erwerb der Personalpronomina im ungesteuerten Spracherwerb. Zeitschrift für Literaturwissenschaft und Linguistik, 45, 35-71.
  • Klein, W. (2000). Der Mythos vom Sprachverfall. In Berlin-Brandenburgische Akademie der Wissenschaften (Ed.), Jahrbuch 1999: Berlin-Brandenburgische Akademie der Wissenschaften (pp. 139-158). Berlin: Akademie Verlag.
  • Klein, W. (1986). Der Wahn vom Sprachverfall und andere Mythen. Zeitschrift für Literaturwissenschaft und Linguistik, 62, 11-28.
  • Klein, W. (1973). Eine Analyse der Kerne in Schillers "Räuber". In S. Marcus (Ed.), Mathematische Poetik (pp. 326-333). Frankfurt am Main: Athenäum.
  • Klein, W. (1973). Eine Analyse der Kerne in Schillers "Räuber". Cahiers de linguistique théorique et appliquée, 10, 195-200.
  • Klein, W. (1982). Einige Bemerkungen zur Frageintonation. Deutsche Sprache, 4, 289-310.

    Abstract

    In the first, critical part of this study, a small sample of simple German sentences with their empirically determined pitch contours is used to demonstrate the incorrectness of numerous currently hold views of German sentence intonation. In the second, more constructive part, several interrogative sentence types are analysed and an attempt is made to show that intonation, besides other functions, indicates the permantently changing 'thematic score' in on-going discourse as well as certain validity claims.
  • Klein, W. (1985). Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, 15(59), 7-8.
  • Klein, W. (1990). Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, 20(78), 7-8.
  • Klein, W. (1982). Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, 12, 7-8.
  • Klein, W. (1986). Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, 16(62), 9-10.
  • Klein, W. (1985). Ellipse, Fokusgliederung und thematischer Stand. In R. Meyer-Hermann, & H. Rieser (Eds.), Ellipsen und fragmentarische Ausdrücke (pp. 1-24). Tübingen: Niemeyer.
  • Klein, W., & Perdue, C. (1986). Comment résourdre une tache verbale complexe avec peu de moyens linguistiques? In A. Giacomi, & D. Véronique (Eds.), Acquisition d'une langue étrangère (pp. 306-330). Aix-en-Provence: Service des Publications de l'Universite de Provence.
  • Klein, W. (1990). Comments on the papers by Bierwisch and Zwicky. Yearbook of Morphology, 3, 217-221.
  • Klein, W. (2000). An analysis of the German perfekt. Language, 76, 358-382.

    Abstract

    The German Perfekt has two quite different temporal readings, as illustrated by the two possible continuations of the sentence Peter hat gearbeitet in i, ii, respectively: (i) Peter hat gearbeitet und ist müde. Peter has worked and is tired. (ii) Peter hat gearbeitet und wollte nicht gestört werden. Peter has worked and wanted not to be disturbed. The first reading essentially corresponds to the English present perfect; the second can take a temporal adverbial with past time reference ('yesterday at five', 'when the phone rang', and so on), and an English translation would require a past tense ('Peter worked/was working'). This article shows that the Perfekt has a uniform temporal meaning that results systematically from the interaction of its three components-finiteness marking, auxiliary and past participle-and that the two readings are the consequence of a structural ambiguity. This analysis also predicts the properties of other participle constructions, in particular the passive in German.
  • Klein, W. (1985). Argumentationsanalyse: Ein Begriffsrahmen und ein Beispiel. In W. Kopperschmidt, & H. Schanze (Eds.), Argumente - Argumentationen (pp. 208-260). München: Fink.
  • Klein, W., Li, P., & Hendriks, H. (2000). Aspect and assertion in Mandarin Chinese. Natural Language & Linguistic Theory, 18, 723-770. doi:10.1023/A:1006411825993.

    Abstract

    Chinese has a number of particles such as le, guo, zai and zhe that add a particular aspectual value to the verb to which they are attached. There have been many characterisations of this value in the literature. In this paper, we review several existing influential accounts of these particles, including those in Li and Thompson (1981), Smith (1991), and Mangione and Li (1993). We argue that all these characterisations are intuitively plausible, but none of them is precise.We propose that these particles serve to mark which part of the sentence''s descriptive content is asserted, and that their aspectual value is a consequence of this function. We provide a simple and precise definition of the meanings of le, guo, zai and zhe in terms of the relationship between topic time and time of situation, and show the consequences of their interaction with different verb expressions within thisnew framework of interpretation.
  • Klein, W. (1973). Dialekt und Einheitssprache im Fremdsprachenunterricht. In Beiträge zu den Sommerkursen des Goethe-Instituts München (pp. 53-60).
  • Klein, W. (2000). Fatale Traditionen. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, (120), 11-40.
  • Klein, W. (1985). Gesprochene Sprache - geschriebene Sprache. Zeitschrift für Literaturwissenschaft und Linguistik, 59, 9-35.
  • Klein, W. (Ed.). (1989). Kindersprache [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (73).
  • Klein, W. (1989). L'Acquisition de langue étrangère. Paris: Armand Colin.
  • Klein, W. (1989). La variation linguistique. In P. Cadiot, & N. Dittmar (Eds.), La sociolinguistique en pays de langue allemande (pp. 101-124). Lille: Presses Universitaires de Lille.
  • Klein, W. (1990). Language acquisition. In M. Piattelli Palmarini (Ed.), Cognitive science in Europe: Issues and trends: Golem monograph series, 1 (pp. 65-77). Ivrea: Golem.
  • Klein, W., & Weissenborn, J. (Eds.). (1982). Here and there: Cross-linguistic studies on deixis and demonstration. Amsterdam: Benjamins.
  • Klein, W. (1982). Local deixis in route directions. In R. Jarvella, & W. Klein (Eds.), Speech, place, and action: Studies in deixis and related topics (pp. 161-182). New York: Wiley.
  • Klein, W., & Von Stechow, A. (1982). Intonation und Bedeutung von Fokus. Konstanz: Universität Konstanz.
  • Klein, W. (1986). Intonation und Satzmodalität in einfachen Fällen: Einige Beobachtungen. In E. Slembek (Ed.), Miteinander sprechen und handeln: Festschrift für Hellmut Geissner (pp. 161-177). Königstein Ts.: Scriptor.
  • Klein, W. (1989). Introspection into what? Review of C. Faerch & G. Kaspar (Eds.) Introspection in second language research 1987. Contemporary Psychology, 34(12), 1119-1120.
  • Klein, W. (1982). Pronoms personnels et formes d'acquisition. Encrages, 8/9, 42-46.
  • Klein, W. (2000). Prozesse des Zweitspracherwerbs. In H. Grimm (Ed.), Enzyklopädie der Psychologie: Vol. 3 (pp. 538-570). Göttingen: Hogrefe.
  • Klein, W. (Ed.). (1982). Speech, place, and action: Studies of language in context. New York: Wiley.
  • Klein, W. (Ed.). (2000). Sprache des Rechts [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (118).
  • Klein, W., & Berliner Arbeitsgruppe (2000). Sprache des Rechts: Vermitteln, Verstehen, Verwechseln. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, (118), 7-33.
  • Klein, W. (Ed.). (1990). Sprache und Raum [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (78).
  • Klein, W. (1990). Sprachverfall. In Ruprecht-Karls-Universität Heidelberg (Ed.), Sprache: Vorträge im Sommersemester (pp. 101-114). Heidelberg: Ruprecht-Karls-Universität.
  • Klein, W. (Ed.). (1986). Sprachverfall [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (62).
  • Klein, W. (1989). Sprechen lernen - das Selbstverständlichste von der Welt: Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik, 73, 7-17.
  • Klein, W. (1989). Schreiben oder Lesen, aber nicht beides, oder: Vorschlag zur Wiedereinführung der Keilschrift mittels Hammer und Meißel. Zeitschrift für Literaturwissenschaft und Linguistik, 74, 116-119.
  • Klein, W. (Ed.). (1985). Schriftlichkeit [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (59).
  • Klein, W. (1985). Sechs Grundgrößen des Spracherwerbs. In R. Eppeneder (Ed.), Lernersprache: Thesen zum Erwerb einer Fremdsprache (pp. 67-106). München: Goethe Institut.
  • Klein, W., & Extra, G. (1982). Second language acquisition by adult immigrants: A European Science Foundation project. In R. E. V. Stuip, & W. Zwanenburg (Eds.), Handelingen van het zevenendertigste Nederlandse Filologencongres (pp. 127-136). Amsterdam: APA-Holland Universiteitspers.
  • Klein, W., & Perdue, C. (1989). The learner's problem of arranging words. In B. MacWhinney, & E. Bates (Eds.), The crosslinguistic study of sentence processing (pp. 292-327). Cambridge: Cambridge University Press.
  • Klein, W. (2000). Was uns die Sprache des Rechts über die Sprache sagt. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, (118), 115-149.
  • Klein, W., & Schlieben-Lange, B. (Eds.). (1990). Zukunft der Sprache [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (79).
  • Klein, W. (Ed.). (1982). Zweitspracherwerb [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (45).
  • Klein, W. (1986). Über Ansehen und Wirkung der deutschen Sprachwissenschaft heute. Linguistische Berichte, 100, 511-520.
  • Klein, W. (1990). Überall und nirgendwo: Subjektive und objektive Momente in der Raumreferenz. Zeitschrift für Literaturwissenschaft und Linguistik, 78, 9-42.
  • Krämer, I. (2000). Interpreting indefinites: An experimental study of children's language comprehension. PhD Thesis, University of Utrecht, Utrecht. doi:10.17617/2.2057626.
  • Lai, C. S. L., Fisher, S. E., Hurst, J. A., Levy, E. R., Hodgson, S., Fox, M., Jeremiah, S., Povey, S., Jamison, D. C., Green, E. D., Vargha-Khadem, F., & Monaco, A. P. (2000). The SPCH1 region on human 7q31: Genomic characterization of the critical interval and localization of translocations associated with speech and language disorder. American Journal of Human Genetics, 67(2), 357-368. doi:10.1086/303011.

    Abstract

    The KE family is a large three-generation pedigree in which half the members are affected with a severe speech and language disorder that is transmitted as an autosomal dominant monogenic trait. In previously published work, we localized the gene responsible (SPCH1) to a 5.6-cM region of 7q31 between D7S2459 and D7S643. In the present study, we have employed bioinformatic analyses to assemble a detailed BAC-/PAC-based sequence map of this interval, containing 152 sequence tagged sites (STSs), 20 known genes, and >7.75 Mb of completed genomic sequence. We screened the affected chromosome 7 from the KE family with 120 of these STSs (average spacing <100 kb), but we did not detect any evidence of a microdeletion. Novel polymorphic markers were generated from the sequence and were used to further localize critical recombination breakpoints in the KE family. This allowed refinement of the SPCH1 interval to a region between new markers 013A and 330B, containing ∼6.1 Mb of completed sequence. In addition, we have studied two unrelated patients with a similar speech and language disorder, who have de novo translocations involving 7q31. Fluorescence in situ hybridization analyses with BACs/PACs from the sequence map localized the t(5;7)(q22;q31.2) breakpoint in the first patient (CS) to a single clone within the newly refined SPCH1 interval. This clone contains the CAGH44 gene, which encodes a brain-expressed protein containing a large polyglutamine stretch. However, we found that the t(2;7)(p23;q31.3) breakpoint in the second patient (BRD) resides within a BAC clone mapping >3.7 Mb distal to this, outside the current SPCH1 critical interval. Finally, we investigated the CAGH44 gene in affected individuals of the KE family, but we found no mutations in the currently known coding sequence. These studies represent further steps toward the isolation of the first gene to be implicated in the development of speech and language.
  • Lansner, A., Sandberg, A., Petersson, K. M., & Ingvar, M. (2000). On forgetful attractor network memories. In H. Malmgren, M. Borga, & L. Niklasson (Eds.), Artificial neural networks in medicine and biology: Proceedings of the ANNIMAB-1 Conference, Göteborg, Sweden, 13-16 May 2000 (pp. 54-62). Heidelberg: Springer Verlag.

    Abstract

    A recurrently connected attractor neural network with a Hebbian learning rule is currently our best ANN analogy for a piece cortex. Functionally biological memory operates on a spectrum of time scales with regard to induction and retention, and it is modulated in complex ways by sub-cortical neuromodulatory systems. Moreover, biological memory networks are commonly believed to be highly distributed and engage many co-operating cortical areas. Here we focus on the temporal aspects of induction and retention of memory in a connectionist type attractor memory model of a piece of cortex. A continuous time, forgetful Bayesian-Hebbian learning rule is described and compared to the characteristics of LTP and LTD seen experimentally. More generally, an attractor network implementing this learning rule can operate as a long-term, intermediate-term, or short-term memory. Modulation of the print-now signal of the learning rule replicates some experimental memory phenomena, like e.g. the von Restorff effect.
  • Levelt, W. J. M. (2000). Uit talloos veel miljoenen. Natuur & Techniek, 68(11), 90.
  • Levelt, W. J. M. (1989). Speaking: From intention to articulation. Cambridge: The MIT Press.
  • Levelt, W. J. M. (1990). De connectionistische mode. In P. Van Hoogstraten (Ed.), Belofte en werkelijkheid: Sociale wetenschappen en informatisering (pp. 39-68). Lisse: Swets & Zeitlinger.
  • Levelt, W. J. M. (1989). De connectionistische mode: Symbolische en subsymbolische modellen van het menselijk gedrag. In C. M. Brown, P. Hagoort, & T. Meijering (Eds.), Vensters op de geest: Cognitie op het snijvlak van filosofie en psychologie (pp. 202-219). Utrecht: Stichting Grafiet.
  • Levelt, W. J. M. (2000). Dyslexie. Natuur & Techniek, 68(4), 64.
  • Levelt, W. J. M. (1982). Cognitive styles in the use of spatial direction terms. In R. Jarvella, & W. Klein (Eds.), Speech, place, and action: Studies in deixis and related topics (pp. 251-268). Chichester: Wiley.
  • Levelt, W. J. M. (1990). Are multilayer feedforward networks effectively turing machines? Psychological Research, 52, 153-157.
  • Levelt, W. J. M. (1973). Formele grammatica's in linguistiek en taalpsychologie (Vols. I-III). Deventer: Van Loghem Slaterus.
  • Levelt, W. J. M. (2000). Met twee woorden spreken [Simon Dik Lezing 2000]. Amsterdam: Vossiuspers AUP.
  • Levelt, W. J. M. (1962). Motion breaking and the perception of causality. In A. Michotte (Ed.), Causalité, permanence et réalité phénoménales: Etudes de psychologie expérimentale (pp. 244-258). Louvain: Publications Universitaires.
  • Levelt, W. J. M., & Plomp, R. (1962). Musical consonance and critical bandwidth. In Proceedings of the 4th International Congress Acoustics (pp. 55-55).
  • Levelt, W. J. M. (1986). Herdenking van Joseph Maria Franciscus Jaspars (16 maart 1934 - 31 juli 1985). In Jaarboek 1986 Koninklijke Nederlandse Akademie van Wetenschappen (pp. 187-189). Amsterdam: North Holland.
  • Levelt, W. J. M. (1982). Het lineariseringsprobleem van de spreker. Tijdschrift voor Taal- en Tekstwetenschap (TTT), 2(1), 1-15.
  • Levelt, W. J. M. (1989). Hochleistung in Millisekunden: Sprechen und Sprache verstehen. Universitas, 44(511), 56-68.

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