Publications

Displaying 101 - 200 of 365
  • Hagoort, P. (1990). [Review of the book Neurolinguistics and linguistic aphasiology: An introduction by David Caplan]. Linguistics, 5, 1069-1073.
  • Hagoort, P. (1989). Processing of lexical ambiguities: a comment on Milberg, Blumstein, and Dworetzky (1987). Brain and Language, 36, 335-348. doi:10.1016/0093-934X(89)90070-9.

    Abstract

    In a study by Milberg, Blumstein, and Dworetzky (1987), normal control subjects and Wernicke's and Broca's aphasics performed a lexical decision task on the third element of auditorily presented triplets of words with either a word or a nonword as target. In three of the four types of word triplets, the first and the third words were related to one or both meanings of the second word, which was semantically ambiguous. The fourth type of word triplet consisted of three unrelated, unambiguous words, functioning as baseline. Milberg et al. (1987) claim that the results for their control subjects are similar to those reported by Schvaneveldt, Meyer, and Becker's original study (1976) with the same prime types, and so interpret these as evidence for a selective lexical access of the different meanings of ambiguous words. It is argued here that Milberg et al. only partially replicate the Schvaneveldt et al. results. Moreover, the results of Milberg et al. are not fully in line with the selective access hypothesis adopted. Replication of the Milberg et al. (1987) study with Dutch materials, using both a design without and a design with repetition of the same target words for the same subjects led to the original pattern as reported by Schvaneveldt et al. (1976). In the design with four separate presentations of the same target word, a strong repetition effect was found. It is therefore argued that the discrepancy between the Milberg et al. results on the one hand, and the Schvaneveldt et al. results on the other, might be due to the absence of a control for repetition effects in the within-subject design used by Milberg et al. It is concluded that this makes the results for both normal and aphasic subjects in the latter study difficult to interpret in terms of a selective access model for normal processing.
  • Hellwig, F. M., & Lüpke, F. (2001). Caused positions. In S. C. Levinson, & N. J. Enfield (Eds.), Manual for the field season 2001 (pp. 126-128). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.874644.

    Abstract

    What kinds of resources to languages have for describing location and position? For some languages, verbs have an important role to play in describing different kinds of situations (e.g., whether a bottle is standing or lying on the table). This task is designed to examine the use of positional verbs in locative constructions, with respect to the presence or absence of a human “positioner”. Participants are asked to describe video clips showing locative states that occur spontaneously, or because of active interference from a person. The task follows on from two earlier tools for the elicitation of static locative descriptions (BowPed and the Ameka picture book task). A number of additional variables (e.g. canonical v. non-canonical orientation of the figure) are also targeted in the stimuli set.

    Additional information

    2001_Caused_positions.zip
  • Hoppenbrouwers, G., Seuren, P. A. M., & Weijters, A. (Eds.). (1985). Meaning and the lexicon. Dordrecht: Foris.
  • Indefrey, P., Brown, C. M., Hellwig, F. M., Amunts, K., Herzog, H., Seitz, R. J., & Hagoort, P. (2001). A neural correlate of syntactic encoding during speech production. Proceedings of the National Academy of Sciences of the United States of America, 98, 5933-5936. doi:10.1073/pnas.101118098.

    Abstract

    Spoken language is one of the most compact and structured ways to convey information. The linguistic ability to structure individual words into larger sentence units permits speakers to express a nearly unlimited range of meanings. This ability is rooted in speakers’ knowledge of syntax and in the corresponding process of syntactic encoding. Syntactic encoding is highly automatized, operates largely outside of conscious awareness, and overlaps closely in time with several other processes of language production. With the use of positron emission tomography we investigated the cortical activations during spoken language production that are related to the syntactic encoding process. In the paradigm of restrictive scene description, utterances varying in complexity of syntactic encoding were elicited. Results provided evidence that the left Rolandic operculum, caudally adjacent to Broca’s area, is involved in both sentence-level and local (phrase-level) syntactic encoding during speaking.
  • Indefrey, P., Hagoort, P., Herzog, H., Seitz, R. J., & Brown, C. M. (2001). Syntactic processing in left prefrontal cortex is independent of lexical meaning. Neuroimage, 14, 546-555. doi:10.1006/nimg.2001.0867.

    Abstract

    In language comprehension a syntactic representation is built up even when the input is semantically uninterpretable. We report data on brain activation during syntactic processing, from an experiment on the detection of grammatical errors in meaningless sentences. The experimental paradigm was such that the syntactic processing was distinguished from other cognitive and linguistic functions. The data reveal that in syntactic error detection an area of the left dorsolateral prefrontal cortex, adjacent to Broca’s area, is specifically involved in the syntactic processing aspects, whereas other prefrontal areas subserve general error detection processes.
  • Janse, E. (2001). Comparing word-level intelligibility after linear vs. non-linear time-compression. In Proceedings of the VIIth European Conference on Speech Communication and Technology Eurospeech (pp. 1407-1410).
  • Jaspers, D., Klooster, W., Putseys, Y., & Seuren, P. A. M. (Eds.). (1989). Sentential complementation and the lexicon: Studies in honour of Wim de Geest. Dordrecht: Foris.
  • Jongen-Janner, E., Pijls, F., & Kempen, G. (1990). Intelligente programma's voor grammatica- en spellingonderwijs. In Q. De Kort, & G. Leerdam (Eds.), Computertoepassingen in de Neerlandistiek. Almere: Landelijke Vereniging van Neerlandici.
  • Jordan, F., & Gray, R. D. (2001). Comment on Terrell, Kelly and Rainbird. Current Anthropology, 42(1), 114-115.
  • Kelly, A., & Melinger, A. (2001). Max-Planck-Institute for Psycholinguistics: Annual Report 2001. Nijmegen: MPI for Psycholinguistics.
  • Kempen, G. (1979). A study of syntactic bookkeeping during sentence production. In H. Ueckert, & D. Rhenius (Eds.), Komplexe menschliche Informationsverarbeitung (pp. 361-368). Bern: Hans Huber.

    Abstract

    It is an important feature of the human sentence production system that semantic and syntactic processes may overlap in time and do not proceed strictly serially. That is, the process of building the syntactic form of an utterance does not always wait until the complete semantic content for that utterance has been decided upon. On the contrary, speakers will often start pronouncing the first words of a sentence while still working on further details of its semantic content. An important advantage is memory economy. Semantic and syntactic fragments do not have to occupy working memory until complete semantic and syntactic structures for an utterance have been computed. Instead, each semantic and syntactic fragment is processed as soon as possible and is kept in working memory for a minimum period of time. This raises the question of how the sentence production system can maintain syntactic coherence across syntactic fragments. Presumably there are processes of "syntactic bookkeeping" which (1) store in working memory those syntactic properties of a fragmentary sentence which are needed to eliminate ungrammatical continuations, and (2) check whether a prospective continuation is indeed compatible with the sentence constructed so far. In reaction time experiments where subjects described, under time pressure, simple static pictures of an action performed by an actor, the second aspect of syntactic bookkeeping could be demonstrated. This evidence is used for modelling bookkeeping processes as part of a computational sentence generator which aims at simulating the syntactic operations people carry out during spontaneous speech.
  • Kempen, G. (1990). Een slordig gestapeld servies [Review of the book Tranen van de krokodil by Piet Vroon]. Intermediair, 26(17), 67-69.
  • Kempen, G., Schotel, H., & Hoenkamp, E. (1982). Analyse-door-synthese van Nederlandse zinnen [Abstract]. De Psycholoog, 17, 509.
  • Kempen, G. (1985). Artificiële intelligentie: Bouw, benutting, beheersing. In W. Veldkamp (Ed.), Innovatie in perspectief (pp. 42-47). Vianen: Nixdorf Computer B.V.
  • Kempen, G. (1973). [Review of the book Psycholinguïstiek by B. Tervoort et al.]. Nederlands Tijdschrift voor de Psychologie, 28, 172-174.
  • Kempen, G., & Hoenkamp, E. (1982). Incremental sentence generation: Implications for the structure of a syntactic processor. In J. Horecký (Ed.), COLING 82. Proceedings of the Ninth International Conference on Computational Linguistics, Prague, July 5-10, 1982 (pp. 151-156). Amsterdam: North-Holland.

    Abstract

    Human speakers often produce sentences incrementally. They can start speaking having in mind only a fragmentary idea of what they want to say, and while saying this they refine the contents underlying subsequent parts of the utterance. This capability imposes a number of constraints on the design of a syntactic processor. This paper explores these constraints and evaluates some recent computational sentence generators from the perspective of incremental production.
  • Kempen, G., & Vosse, T. (1989). Incremental syntactic tree formation in human sentence processing: A cognitive architecture based on activation decay and simulated annealing. Connection Science, 1(3), 273-290. doi:10.1080/09540098908915642.

    Abstract

    A new cognitive architecture is proposed for the syntactic aspects of human sentence processing. The architecture, called Unification Space, is biologically inspired but not based on neural nets. Instead it relies on biosynthesis as a basic metaphor. We use simulated annealing as an optimization technique which searches for the best configuration of isolated syntactic segments or subtrees in the final parse tree. The gradually decaying activation of individual syntactic nodes determines the ‘global excitation level’ of the system. This parameter serves the function of ‘computational temperature’ in simulated annealing. We have built a computer implementation of the architecture which simulates well-known sentence understanding phenomena. We report successful simulations of the psycholinguistic effects of clause embedding, minimal attachment, right association and lexical ambiguity. In addition, we simulated impaired sentence understanding as observable in agrammatic patients. Since the Unification Space allows for contextual (semantic and pragmatic) influences on the syntactic tree formation process, it belongs to the class of interactive sentence processing models.
  • Kempen, G. (1989). Informatiegedragskunde: Pijler van de moderne informatieverzorging. In A. F. Marks (Ed.), Sociaal-wetenschappelijke informatie en kennisvorming in onderzoek, onderzoeksbeleid en beroep (pp. 31-35). Amsterdam: SWIDOC.
  • Kempen, G. (1990). Microcomputers en cognitiewetenschap. SURF: Tijdschrift over Computerdienstverlening in het Hoger Onderwijs en Onderzoek, 4(3), 2.
  • Kempen, G., & Jongen-Janner, E. (1990). Naar een flexibele methode voor algoritmisch grammatica- en spellingonderwijs. Pedagogisch Tijdschrift, 15, 280-289.
  • Kempen, G. (1979). La mise en paroles, aspects psychologiques de l'expression orale. Études de Linguistique Appliquée, 33, 19-28.

    Abstract

    Remarques sur les facteurs intervenant dans le processus de formulation des énoncés.
  • Kempen, G. (1989). Language generation systems. In I. S. Bátori, W. Lenders, & W. Putschke (Eds.), Computational linguistics: An international handbook on computer oriented language research and applications (pp. 471-480). Berlin/New York: Walter de Gruyter.
  • Kempen, G. (1985). Psychologie 2000. Toegepaste psychologie in de informatiemaatschappij. Computers in de psychologie, 13-21.
  • Kempen, G. (1979). Psychologie van de zinsbouw: Een Wundtiaanse inleiding. Nederlands Tijdschrift voor de Psychologie, 34, 533-551.

    Abstract

    The psychology of language as developed by Wilhelm Wundt in his fundamental work Die Sprache (1900) has a strongly mentalistic character. The dominating positions held by behaviorism in psychology and structuralism in linguistics have overruled Wundt’s language theory to the effect that it has remained relatively unknown. This situation has changed recently under the influence of transformational linguistics and cognitive psychology. The paper discusses how Wundt applied the basic psychological concepts of apperception and association to language behavior, in particular to the construction and production of sentences during unprepared speech. The final part of the paper is devoted to the work, published in 1917, of the Dutch linguistic scholar Jacques van Ginneken, who elaborated Wundt’s ideas towards an explanation of some syntactic phenomena during the language acquisition of children.
  • Kempen, G. (1990). Representation in memory: Volume 2, chapter 8, pp. 511–587 by David E. Rumelhart and Donald A. Norman [Book review]. Acta Psychologica, 75, 191-192. doi:10.1016/0001-6918(90)90107-Q.
  • Kempen, G. (1990). Taaltechnologie en de toekomst van tekstautomatisering. Informatie, 32, 724-727.
  • Kempen, G., Schotel, H., & Pijls, J. (1985). Taaltechnologie en taalonderwijs. In J. Heene (Ed.), Onderwijs en informatietechnologie. Den Haag: Stichting voor Onderzoek van het Onderwijs (SVO).
  • Kempen, G. (1979). Woordwaarde. De Psycholoog, 14, 577.
  • Kidd, E., Bavin, E. L., & Rhodes, B. (2001). Two-year-olds' knowledge of verbs and argument structures. In M. Almgren, A. Barreña, M.-J. Ezeuzabarrena, I. Idiazabal, & B. MacWhinney (Eds.), Research on child language acquisition: Proceedings of the 8th Conference of the International Association for the Study of Child language (pp. 1368-1382). Sommerville: Cascadilla Press.
  • Kilborn, K., & Weissenborn, J. (1989). Max-Planck-Institute for Psycholinguistics: Annual Report Nr.10 1989. Nijmegen: MPI for Psycholinguistics.
  • Kita, S., Danziger, E., & Stolz, C. (2001). Cultural specificity of spatial schemas, as manifested in spontaneous gestures. In M. Gattis (Ed.), Spatial Schemas and Abstract Thought (pp. 115-146). Cambridge, MA, USA: MIT Press.
  • Kita, S. (2001). Locally-anchored spatial gestures, version 2: Historical description of the local environment as a gesture elicitation task. In S. C. Levinson, & N. J. Enfield (Eds.), Manual for the field season 2001 (pp. 132-135). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.874647.

    Abstract

    Gesture is an integral part of face-to-face communication, and provides a rich area for cross-cultural comparison. “Locally-anchored spatial gestures” are gestures that are roughly oriented to the actual geographical direction of referents. For example, such gestures may point to a location or a thing, trace the shape of a path, or indicate the direction of a particular area. The goal of this task is to elicit locally-anchored spatial gestures across different cultures. The task follows an interview format, where one participant prompts another to talk in detail about a specific area that the main speaker knows well. The data can be used for additional purposes such as the investigation of demonstratives.
  • Kita, S. (2001). Recording recommendations for gesture studies. In S. C. Levinson, & N. J. Enfield (Eds.), Manual for the field season 2001 (pp. 130-131). Nijmegen: Max Planck Institute for Psycholinguistics.
  • Klein, W. (1990). A theory of language acquisition is not so easy. Studies in Second Language Acquisition, 12, 219-231. doi:10.1017/S0272263100009104.
  • Klein, W. (2001). Das Ende vor Augen: Deutsch als Wissenschaftssprache. In F. Debus, F. Kollmann, & U. Pörken (Eds.), Deutsch als Wissenschaftssprache im 20. Jahrhundert (pp. 289-293). Mainz: Akademie der Wissenschaften und der Literatur.
  • Klein, W. (2001). Deiktische Orientierung. In M. Haspelmath, E. König, W. Oesterreicher, & W. Raible (Eds.), Sprachtypologie und sprachliche Universalien: Vol. 1/1 (pp. 575-590). Berlin: de Gruyter.
  • Klein, W., & Rieck, B.-O. (1982). Der Erwerb der Personalpronomina im ungesteuerten Spracherwerb. Zeitschrift für Literaturwissenschaft und Linguistik, 45, 35-71.
  • Klein, W. (2001). Ein Gemeinwesen, in dem das Volk herrscht, darf nicht von Gesetzen beherrscht werden, die das Volk nicht versteht. Rechtshistorisches Journal, 20, 621-628.
  • Klein, W. (1973). Eine Analyse der Kerne in Schillers "Räuber". In S. Marcus (Ed.), Mathematische Poetik (pp. 326-333). Frankfurt am Main: Athenäum.
  • Klein, W. (1973). Eine Analyse der Kerne in Schillers "Räuber". Cahiers de linguistique théorique et appliquée, 10, 195-200.
  • Klein, W. (1982). Einige Bemerkungen zur Frageintonation. Deutsche Sprache, 4, 289-310.

    Abstract

    In the first, critical part of this study, a small sample of simple German sentences with their empirically determined pitch contours is used to demonstrate the incorrectness of numerous currently hold views of German sentence intonation. In the second, more constructive part, several interrogative sentence types are analysed and an attempt is made to show that intonation, besides other functions, indicates the permantently changing 'thematic score' in on-going discourse as well as certain validity claims.
  • Klein, W. (1985). Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, 15(59), 7-8.
  • Klein, W. (1990). Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, 20(78), 7-8.
  • Klein, W. (1982). Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, 12, 7-8.
  • Klein, W. (1979). Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, 9(33), 7-8.
  • Klein, W. (2001). Elementary forms of linguistic organisation. In S. Ward, & J. Trabant (Eds.), The origins of language (pp. 81-102). Berlin: Mouton de Gruyter.
  • Klein, W. (1985). Ellipse, Fokusgliederung und thematischer Stand. In R. Meyer-Hermann, & H. Rieser (Eds.), Ellipsen und fragmentarische Ausdrücke (pp. 1-24). Tübingen: Niemeyer.
  • Klein, W., & Dittmar, N. (1979). Developing grammars. Berlin: Springer.
  • Klein, W. (2001). Die Linguistik ist anders geworden. In S. Anschütz, S. Kanngießer, & G. Rickheit (Eds.), A Festschrift for Manfred Briegel: Spektren der Linguistik (pp. 51-72). Wiesbaden: Deutscher Universitätsverlag.
  • Klein, W. (1990). Comments on the papers by Bierwisch and Zwicky. Yearbook of Morphology, 3, 217-221.
  • Klein, W. (1985). Argumentationsanalyse: Ein Begriffsrahmen und ein Beispiel. In W. Kopperschmidt, & H. Schanze (Eds.), Argumente - Argumentationen (pp. 208-260). München: Fink.
  • Klein, W. (1979). Die Geschichte eines Tores. In R. Baum, F. J. Hausmann, & I. Monreal-Wickert (Eds.), Sprache in Unterricht und Forschung: Schwerpunkt Romanistik (pp. 175-194). Tübingen: Narr.
  • Klein, W. (1973). Dialekt und Einheitssprache im Fremdsprachenunterricht. In Beiträge zu den Sommerkursen des Goethe-Instituts München (pp. 53-60).
  • Klein, W. (1985). Gesprochene Sprache - geschriebene Sprache. Zeitschrift für Literaturwissenschaft und Linguistik, 59, 9-35.
  • Klein, W. (Ed.). (1989). Kindersprache [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (73).
  • Klein, W. (1989). L'Acquisition de langue étrangère. Paris: Armand Colin.
  • Klein, W. (1989). La variation linguistique. In P. Cadiot, & N. Dittmar (Eds.), La sociolinguistique en pays de langue allemande (pp. 101-124). Lille: Presses Universitaires de Lille.
  • Klein, W. (1990). Language acquisition. In M. Piattelli Palmarini (Ed.), Cognitive science in Europe: Issues and trends: Golem monograph series, 1 (pp. 65-77). Ivrea: Golem.
  • Klein, W., & Weissenborn, J. (Eds.). (1982). Here and there: Cross-linguistic studies on deixis and demonstration. Amsterdam: Benjamins.
  • Klein, W. (2001). Lexicology and lexicography. In N. Smelser, & P. Baltes (Eds.), International encyclopedia of the social & behavioral sciences: Vol. 13 (pp. 8764-8768). Amsterdam: Elsevier Science.
  • Klein, W. (1982). Local deixis in route directions. In R. Jarvella, & W. Klein (Eds.), Speech, place, and action: Studies in deixis and related topics (pp. 161-182). New York: Wiley.
  • Klein, W., & Von Stechow, A. (1982). Intonation und Bedeutung von Fokus. Konstanz: Universität Konstanz.
  • Klein, W. (1989). Introspection into what? Review of C. Faerch & G. Kaspar (Eds.) Introspection in second language research 1987. Contemporary Psychology, 34(12), 1119-1120.
  • Klein, W. (1982). Pronoms personnels et formes d'acquisition. Encrages, 8/9, 42-46.
  • Klein, W. (Ed.). (1982). Speech, place, and action: Studies of language in context. New York: Wiley.
  • Klein, W. (Ed.). (1979). Sprache und Kontext [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (33).
  • Klein, W. (Ed.). (1990). Sprache und Raum [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (78).
  • Klein, W. (1990). Sprachverfall. In Ruprecht-Karls-Universität Heidelberg (Ed.), Sprache: Vorträge im Sommersemester (pp. 101-114). Heidelberg: Ruprecht-Karls-Universität.
  • Klein, W. (1989). Sprechen lernen - das Selbstverständlichste von der Welt: Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik, 73, 7-17.
  • Klein, W. (1989). Schreiben oder Lesen, aber nicht beides, oder: Vorschlag zur Wiedereinführung der Keilschrift mittels Hammer und Meißel. Zeitschrift für Literaturwissenschaft und Linguistik, 74, 116-119.
  • Klein, W. (Ed.). (1985). Schriftlichkeit [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (59).
  • Klein, W. (1985). Sechs Grundgrößen des Spracherwerbs. In R. Eppeneder (Ed.), Lernersprache: Thesen zum Erwerb einer Fremdsprache (pp. 67-106). München: Goethe Institut.
  • Klein, W. (2001). Second language acquisition. In N. Smelser, & P. Baltes (Eds.), International encyclopedia of the social & behavioral sciences: Vol. 20 (pp. 13768-13771). Amsterdam: Elsevier science.
  • Klein, W., & Extra, G. (1982). Second language acquisition by adult immigrants: A European Science Foundation project. In R. E. V. Stuip, & W. Zwanenburg (Eds.), Handelingen van het zevenendertigste Nederlandse Filologencongres (pp. 127-136). Amsterdam: APA-Holland Universiteitspers.
  • Klein, W., & Perdue, C. (1989). The learner's problem of arranging words. In B. MacWhinney, & E. Bates (Eds.), The crosslinguistic study of sentence processing (pp. 292-327). Cambridge: Cambridge University Press.
  • Klein, W. (1979). Wegauskünfte. Zeitschrift für Literaturwissenschaft und Linguistik, 33, 9-57.
  • Klein, W. (2001). Time and again. In C. Féry, & W. Sternefeld (Eds.), Audiatur vox sapientiae: A festschrift for Arnim von Stechow (pp. 267-286). Berlin: Akademie Verlag.
  • Klein, W., & Schlieben-Lange, B. (Eds.). (1990). Zukunft der Sprache [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (79).
  • Klein, W. (Ed.). (1982). Zweitspracherwerb [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (45).
  • Klein, W. (2001). Typen und Konzepte des Spracherwerbs. In L. Götze, G. Helbig, G. Henrici, & H. Krumm (Eds.), Deutsch als Fremdsprache (pp. 604-616). Berlin: de Gruyter.
  • Klein, W. (1990). Überall und nirgendwo: Subjektive und objektive Momente in der Raumreferenz. Zeitschrift für Literaturwissenschaft und Linguistik, 78, 9-42.
  • Knösche, T. R., & Bastiaansen, M. C. M. (2001). Does the Hilbert transform improve accuracy and time resolution of ERD/ERS? Biomedizinische Technik, 46(2), 106-108.
  • Krott, A. (2001). Analogy in morphology: The selection of linking elements in Dutch compounds. PhD Thesis, Radboud University Nijmegen, Nijmegen. doi:10.17617/2.2057602.
  • Lai, C. S. L., Fisher, S. E., Hurst, J. A., Vargha-Khadem, F., & Monaco, A. P. (2001). A forkhead-domain gene is mutated in a severe speech and language disorder[Letters to Nature]. Nature, 413, 519-523. doi:10.1038/35097076.

    Abstract

    Individuals affected with developmental disorders of speech and language have substantial difficulty acquiring expressive and/or receptive language in the absence of any profound sensory or neurological impairment and despite adequate intelligence and opportunity. Although studies of twins consistently indicate that a significant genetic component is involved, most families segregating speech and language deficits show complex patterns of inheritance, and a gene that predisposes individuals to such disorders has not been identified. We have studied a unique three-generation pedigree, KE, in which a severe speech and language disorder is transmitted as an autosomal-dominant monogenic trait. Our previous work mapped the locus responsible, SPCH1, to a 5.6-cM interval of region 7q31 on chromosome 7 (ref. 5). We also identified an unrelated individual, CS, in whom speech and language impairment is associated with a chromosomal translocation involving the SPCH1 interval. Here we show that the gene FOXP2, which encodes a putative transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain, is directly disrupted by the translocation breakpoint in CS. In addition, we identify a point mutation in affected members of the KE family that alters an invariant amino-acid residue in the forkhead domain. Our findings suggest that FOXP2 is involved in the developmental process that culminates in speech and language
  • Lausberg, H., & Kita, S. (2001). Hemispheric specialization in nonverbal gesticulation investigated in patients with callosal disconnection. In C. Cavé, I. Guaïtella, & S. Santi (Eds.), Oralité et gestualité: Interactions et comportements multimodaux dans la communication. Actes du colloque ORAGE 2001 (pp. 266-270). Paris, France: Éditions L'Harmattan.
  • Ledberg, A., Fransson, P., Larsson, J., & Petersson, K. M. (2001). A 4D approach to the analysis of functional brain images: Application to fMRI data. Human Brain Mapping, 13, 185-198. doi:10.1002/hbm.1032.

    Abstract

    This paper presents a new approach to functional magnetic resonance imaging (FMRI) data analysis. The main difference lies in the view of what comprises an observation. Here we treat the data from one scanning session (comprising t volumes, say) as one observation. This is contrary to the conventional way of looking at the data where each session is treated as t different observations. Thus instead of viewing the v voxels comprising the 3D volume of the brain as the variables, we suggest the usage of the vt hypervoxels comprising the 4D volume of the brain-over-session as the variables. A linear model is fitted to the 4D volumes originating from different sessions. Parameter estimation and hypothesis testing in this model can be performed with standard techniques. The hypothesis testing generates 4D statistical images (SIs) to which any relevant test statistic can be applied. In this paper we describe two test statistics, one voxel based and one cluster based, that can be used to test a range of hypotheses. There are several benefits in treating the data from each session as one observation, two of which are: (i) the temporal characteristics of the signal can be investigated without an explicit model for the blood oxygenation level dependent (BOLD) contrast response function, and (ii) the observations (sessions) can be assumed to be independent and hence inference on the 4D SI can be made by nonparametric or Monte Carlo methods. The suggested 4D approach is applied to FMRI data and is shown to accurately detect the expected signal
  • Levelt, W. J. M. (2001). The architecture of normal spoken language use. In G. Gupta (Ed.), Cognitive science: Issues and perspectives (pp. 457-473). New Delhi: Icon Publications.
  • Levelt, W. J. M. (1989). Speaking: From intention to articulation. Cambridge: The MIT Press.
  • Levelt, W. J. M. (1990). De connectionistische mode. In P. Van Hoogstraten (Ed.), Belofte en werkelijkheid: Sociale wetenschappen en informatisering (pp. 39-68). Lisse: Swets & Zeitlinger.
  • Levelt, W. J. M. (1989). De connectionistische mode: Symbolische en subsymbolische modellen van het menselijk gedrag. In C. M. Brown, P. Hagoort, & T. Meijering (Eds.), Vensters op de geest: Cognitie op het snijvlak van filosofie en psychologie (pp. 202-219). Utrecht: Stichting Grafiet.
  • Levelt, W. J. M. (2001). De vlieger die (onverwacht) wel opgaat. Natuur & Techniek, 69(6), 60.
  • Levelt, W. J. M. (2001). Defining dyslexia. Science, 292, 1300-1301.
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    Abstract

    The topic of this paper is the way in which speakers order information in discourse. I will refer to this issue with the term "linearization", and will begin with two types of general remarks. The first one concerns the scope and relevance of the problem with reference to some existing literature. The second set of general remarks will be about the place of linearization in a theory of the speaker. The following, and main part of this paper, will be a summary report of research of linearization in a limited, but well-defined domain of discourse, namely the description of spatial networks.

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