Publications

Abstract

This study investigates the time-course of information processing in both visual as well as in the auditory speech as used for word identification in face-to-face communication. It extends the limited previous research on this topic and provides a valuable database for future research in audiovisual speech perception. An evaluation of models of speech perception by ear and eye in their ability to account for the audiovisual gating data shows a superior role of the fuzzy logical model of perception (FLMP) [1] over additive models of perception. A new dynamic version of the FLMP seems to be a promising model to account for the complex interplay of perceptual and cognitive information in audiovisual spoken word recognition.

Abstract

Mutations of the epidermal growth factor receptor (EGFR) gene are found at a relatively high frequency in glioma, with the most common being the de2-7 EGFR (or EGFRvIII). This mutation arises from an in-frame deletion of exons 2–7, which removes 267 amino acids from the extracellular domain of the receptor. Despite being unable to bind ligand, the de2-7 EGFR is constitutively active at a low level. Transfection of human glioma cells with the de2-7 EGFR has little effect in vitro, but when grown as tumor xenografts this mutated receptor imparts a dramatic growth advantage. We have now mapped the phosphorylation pattern of de2-7 EGFR, both in vivo and in vitro, using a panel of antibodies unique to the different phosphorylated tyrosine residues. Phosphorylation of de2-7 EGFR was detected constitutively at all tyrosine sites surveyed both in vitro and in vivo, including tyrosine 845, a known target in the wild-type EGFR for src kinase. There was a substantial upregulation of phosphorylation at every tyrosine residue of the de2-7 EGFR when cells were grown in vivo compared to the receptor isolated from cells cultured in vitro. Upregulation of phosphorylation could be mimicked in vitro by the addition of specifi c components of the ECM such as collagen via an integrin-dependent mechanism. Since this increase in in vivo phosphorylation enhances de2-7 EGFR signaling, this observation explains why the growth enhancement mediated by de2-7 EGFR is largely restricted to the in vivo environment. In a second set of experiments we analyzed the interaction between EGFRvIII and ErbB2. Co-expression of these proteins in NR6 cells, a mouse fi broblast line devoid of ErbB family members, dramatically enhanced in vivo tumorigenicity of these cells compared to cells expressing either protein alone. Detailed analysis of these xenografts demonstrated that EGFRvIII could heterodimerize and transphosphorylate the ErbB2. Since both EGFRvIII and ErbB2 are commonly expressed at gliomas, this data suggests that the co-expression of these two proteins may enhance glioma tumorigenicity.

Abstract

Day-to-day interpretations of “space” are enmeshed in specific cultural and linguistic practices. For example, many cultures have an association between vertical height and social standing; more powerful people may be placed literally higher than others at social gatherings, and be spoken of as having higher status. This questionnaire is a guide for exploring relationships between space, language, and social structure. The goal is to better understand how space is organised in the focus community, and to investigate the extent to which space is used as a model for reproducing social forms.

Abstract

This task investigates the expression of “enter” and “exit” events, and is a supplement to the Motion Elicitation task (https://doi.org/10.17617/2.3003391). Consultants are asked to describe a series of animated clips where a man moves into or out of a house. The clips focus on contrasts to do with perspective (e.g., whether the man appears to move away or towards the viewer) and transitional movement (e.g., whether the man walks or “teleports” into his new location).

Abstract

Do our hands 'speak the same language' across cultures? Gesture is the silent partner of spoken languages in face-to-face interaction, but we still have a lot to learn about gesture practices in different speech communities. The primary purpose of this task is to collect data in naturalistic settings that can be used to investigate the linguistic and cultural relativity of gesture performance, especially spatially indicative gestures. It involves video-recording pairs of speakers in both free conversation and more structured communication tasks (e.g., describing film plots).

Please note: the stimuli mentioned in this entry are available elsewhere: 'The Pear Story', a short film made at the University of California at Berkeley; "Frog, where are you?" from the original Mayer (1969) book, as published in the Appendix of Berman & Slobin (1994).

Abstract

This paper examines the language-specific aspect of the TIME PASSING IS MOTION metaphor and suggests that the temporal construal of time can be influenced by a person's second language. Ahrens and Huang (2002) have analyzed the source domain of MOTION for the TIME metaphor into two special cases. In the special case one, TIME PASSING is an object that moves towards an ego. For example, qimuokao kuai dao le "the final exam is approaching." In the special case two, TIME PASSING is a point (that a plural ego is attached to) that moves across a landscape. For example, women kuai dao qimuokao le "we are approaching the final exam." In addition, in English, the ego in the special case one faces the future while in Chinese, the ego faces the past. The current experiment hypothesizes that English influences the choice of the orientation of the ego in native Chinese speakers who speak English as the second language. 54 subjects are asked to switch the clock time one hour forward. Results show that native Chinese speakers living in the Chinese speaking country tend to move the clock one hour forward to the past (92%) while native Chinese speakers living in an English speaking country are less likely to do so (60%). This implies that the experience of English influences the conceptualization of time in Mandarin Chinese.

Abstract

Mental imagery is a cognitive process crucial to human reasoning. Numerous studies have characterized specific
instances of this cognitive ability, as evoked by visual imagery (VI) or motor imagery (MI) tasks. However, it
remains unclear which neural resources are shared between VI and MI, and which are exclusively related to MI.
To address this issue, we have used fMRI to measure human brain activity during performance of VI and MI
tasks. Crucially, we have modulated the imagery process by manipulating the degree of mental rotation necessary
to solve the tasks. We focused our analysis on changes in neural signal as a function of the degree of mental
rotation in each task.

Abstract

In this paper we report on four experiments in which we attempted to prime the stress position of Dutch bisyllabic target nouns. These nouns, picture names, had stress on either the first or the second syllable. Auditory prime words had either the same stress as the target or a different stress (e.g., WORtel – MOtor vs. koSTUUM – MOtor; capital letters indicate stressed syllables in prime – target pairs). Furthermore, half of the prime words were semantically related, the other half were unrelated. In none of the experiments a stress priming effect was found. This could mean that stress is not stored in the lexicon. An additional finding was that targets with initial stress had a faster response than targets with a final stress. We hypothesize that bisyllabic words with final stress take longer to be encoded because this stress pattern is irregular with respect to the lexical distribution of bisyllabic stress patterns, even though it can be regular in terms of the metrical stress rules of Dutch.

Abstract

It has been hypothesised that human reasoning has a non-linguistic foundation, but is nevertheless influenced by the formal means available in a language. For example, Western logic is transparently related to European sentential connectives (e.g., and, if … then, or, not), some of which cannot be unambiguously expressed in other languages. The questionnaire explores reasoning tools and practices through investigating translation equivalents of English sentential connectives and collecting examples of “reasoned arguments”.

Abstract

Recent research suggests that 12-month-old infants in German cultural settings have the motive of sharing their attention to and interest in various events with a social interlocutor. To do so, these preverbal infants predominantly use the pointing gesture (in this case the extended arm with or without extended index finger) as a means to direct another person’s attention. This task systematically investigates different types of motives underlying infants’ pointing. The occurrence of a protodeclarative (as opposed to protoimperative) motive is of particular interest because it requires an understanding of the recipient’s psychological states, such as attention and interest, that can be directed and accessed.

Abstract

There are three main strands of research which have investigated people’s intuitive knowledge of objects in motion. (1) Knowledge of the trajectories of objects in motion; (2) knowledge of the causes of motion; and (3) the categorisation of motion as to whether it has been produced by something animate or inanimate. We provide a brief introduction to each of these areas. We then point to some linguistic and cultural differences which may have consequences for people’s knowledge of objects in motion. Finally, we describe two experimental tasks and an ethnographic task that will allow us to collect data in order to establish whether, indeed, there are interesting cross-linguistic/cross-cultural differences in lay theories of objects in motion.

Abstract

Words are fundamental to reading and yet over a century of research has not masked the controversies around how words are recognized. We review some old and new research that disproves simple ideas such as words are read as wholes or are simply mapped directly to spoken language. We also review theory and research relevant to the question of sublexical influences in word recognition. We describe orthography and phonology, how they are related to each other and describe a series of new experiments on how these sources of information are processed. Tasks include lexical decision, perceptual identification, and naming. Dependent measures are reaction time, accuracy of performance, and a new measure, initial phoneme duration, that refers to the duration of the first phoneme when the target word is pronounced. Important factors in resolving the controversies include the realization that reading has multiple determinants, as well as evaluating the type of task, proper controls such as familiarity of the test items and accuracy of measurement of the response. We also address potential limitations with measures related to the mapping between orthography and phonology, and show that the existence of a sound-to-spelling consistency effect does not require interactive activation, but can be explained and predicted by a feedforward model, the Fuzzy logical model of perception.

Abstract

Japanese, British English and American English listeners were presented with spoken words in their native language, and asked to mark on a written transcript of each word the first natural division point in the word. The results showed clear and strong patterns of consensus, indicating that listeners have available to them conscious representations of within-word structure. Orthography did not play a strongly deciding role in the results. The patterns of response were at variance with results from on-line studies of speech segmentation, suggesting that the present task taps not those representations used in on-line listening, but levels of representation which may involve much richer knowledge of word-internal structure.

Abstract

In this paper we describe a general scheme for internationalization of our talking head, Baldi, to speak other languages. We describe the modular structure of the auditory/visual synthesis software. As an example, we have created a synthetic Arabic talker, which is evaluated using a noisy word recognition task comparing this talker with a natural one.