Publications

Abstract

nfants start learning words, the building blocks of language, at least by 6 months. To do so, they must be able to extract the phonological form of words from running speech. A rich literature has investigated this process, termed word segmentation. We addressed the fundamental question of how infants of different ages segment words from their native language using a meta-analytic approach. Based on previous popular theoretical and experimental work, we expected infants to display familiarity preferences early on, with a switch to novelty preferences as infants become more proficient at processing and segmenting native speech. We also considered the possibility that this switch may occur at different points in time as a function of infants' native language and took into account the impact of various task- and stimulus-related factors that might affect difficulty. The combined results from 168 experiments reporting on data gathered from 3774 infants revealed a persistent familiarity preference across all ages. There was no significant effect of additional factors, including native language and experiment design. Further analyses revealed no sign of selective data collection or reporting. We conclude that models of infant information processing that are frequently cited in this domain may not, in fact, apply in the case of segmenting words from native speech.

Abstract

How does a naive language learner deal with speaker variation irrelevant to distinguishing word meanings? Experimental data is contradictory, and incompatible models have been proposed. Here, we examine basic assumptions regarding the acoustic signal the learner deals with: Is speaker variability a hurdle in discriminating sounds or can it easily be ignored? To this end, we summarize existing infant data. We then present machine-based discriminability scores of sound pairs obtained without any language knowledge. Our results show that speaker variability decreases sound contrast discriminability, and that some contrasts are affected more than others. However, chance performance is rare; most contrasts remain discriminable in the face of speaker variation. We take our results to mean that speaker variation is not a uniform hurdle to discriminating sound contrasts, and careful examination is necessary when planning and interpreting studies testing whether and to what extent infants (and adults) are sensitive to speaker differences.

Abstract

During language acquisition, infants frequently encounter ambient noise. We present a computational model to address whether specific acoustic processing abilities are necessary to detect known words in moderate noise—an ability attested experimentally in infants. The model implements a general purpose speech encoding and word detection procedure. Importantly, the model contains no dedicated processes for removing or cancelling out ambient noise, and it can replicate the patterns of results obtained in several infant experiments. In addition to noise, we also addressed the role of previous experience with particular target words: does the frequency of a word matter, and does it play a role whether that word has been spoken by one or multiple speakers? The simulation results show that both factors affect noise robustness. We also investigated how robust word detection is to changes in speaker identity by comparing words spoken by known versus unknown speakers during the simulated test. This factor interacted with both noise level and past experience, showing that an increase in exposure is only helpful when a familiar speaker provides the test material. Added variability proved helpful only when encountering an unknown speaker. Finally, we addressed whether infants need to recognise specific words, or whether a more parsimonious explanation of infant behaviour, which we refer to as matching, is sufficient. Recognition involves a focus of attention on a specific target word, while matching only requires finding the best correspondence of acoustic input to a known pattern in the memory. Attending to a specific target word proves to be more noise robust, but a general word matching procedure can be sufficient to simulate experimental data stemming from young infants. A change from acoustic matching to targeted recognition provides an explanation of the improvements observed in infants around their first birthday. In summary, we present a computational model incorporating only the processes infants might employ when hearing words in noise. Our findings show that a parsimonious interpretation of behaviour is sufficient and we offer a formal account of emerging abilities.

Abstract

Most people like symmetry, and symmetry has been extensively used in visual art and architecture. In this study, we compared preference for images of abstract and familiar objects in the original format or when containing perfect bilateral symmetry. We created pairs of images for different categories: male faces, female faces, polygons, smoothed version of the polygons, flowers, and landscapes. This design allows us to compare symmetry preference in different domains. Each observer saw all categories randomly interleaved but saw only one of the two images in a pair. After recording preference, we recorded a rating of how salient the symmetry was for each image, and measured how quickly observers could decide which of the two images in a pair was symmetrical. Results reveal a general preference for symmetry in the case of shapes and faces. For landscapes, natural (no perfect symmetry) images were preferred. Correlations with judgments of saliency were present but generally low, and for landscapes the salience of symmetry was negatively related to preference. However, even within the category where symmetry was not liked (landscapes), the separate analysis of original and modified stimuli showed an interesting pattern: Salience of symmetry was correlated positively (artificial) or negatively (original) with preference, suggesting different effects of symmetry within the same class of stimuli based on context and categorization.

Abstract

Following right-hemisphere damage, a specific disorder of motor awareness can occur called anosognosia for hemiplegia, i.e. the denial of motor deficits contralateral to a brain lesion. The study of anosognosia can offer unique insights into the neurocognitive basis of awareness. Typically, however, awareness is assessed as a first person judgement and the ability of patients to think about their bodies in more ‘objective’ (third person) terms is not directly assessed. This may be important as right-hemisphere spatial abilities may underlie our ability to take third person perspectives. This possibility was assessed for the first time in the present study. We investigated third person perspective taking using both visuospatial and verbal tasks in right-hemisphere stroke patients with anosognosia ( n = 15) and without anosognosia ( n = 15), as well as neurologically healthy control subjects ( n = 15). The anosognosic group performed worse than both control groups when having to perform the tasks from a third versus a first person perspective. Individual analysis further revealed a classical dissociation between most anosognosic patients and control subjects in mental (but not visuospatial) third person perspective taking abilities. Finally, the severity of unawareness in anosognosia patients was correlated to greater impairments in such third person, mental perspective taking abilities (but not visuospatial perspective taking). In voxel-based lesion mapping we also identified the lesion sites linked with such deficits, including some brain areas previously associated with inhibition, perspective taking and mentalizing, such as the inferior and middle frontal gyri, as well as the supramarginal and superior temporal gyri. These results suggest that neurocognitive deficits in mental perspective taking may contribute to anosognosia and provide novel insights regarding the relation between self-awareness and social cognition.

Abstract

It is known that cortical networks operate on the edge of instability, in which oscillations can appear. However, the influence of this dynamic regime on performance in decision making, is not well understood. In this work, we propose a population model of decision making based on a winner-take-all mechanism. Using this model, we demonstrate that local slow inhibition within the competing neuronal populations can lead to Hopf bifurcation. At the edge of instability, the system exhibits ambiguity in the decision making, which can account for the perceptual switches observed in human experiments. We further validate this model with fMRI datasets from an experiment on semantic priming in perception of ambivalent (male versus female) faces. We demonstrate that the model can correctly predict the drop in the variance of the BOLD within the Superior Parietal Area and Inferior Parietal Area while watching ambiguous visual stimuli.

Abstract

The Chapacuran language family, with three extant members and nine historically attested lects, has yet to be classified following modern standards in historical linguistics. This paper presents an internal classification of these languages by combining both the traditional comparative method (CM) and Bayesian phylogenetic inference (BPI). We identify multiple systematic sound correspondences and 285 cognate sets of basic vocabulary using the available documentation. These allow us to reconstruct a large portion of the Proto-Chapacuran phonemic inventory and identify tentative major subgroupings. The cognate sets form the input for the BPI analysis, which uses a stochastic Continuous-Time Markov Chain to model the change of these cognate sets over time. We test various models of lexical substitution and evolutionary clocks, and use ethnohistorical information and data collection dates to calibrate the resulting trees. The CM and BPI analyses produce largely congruent results, suggesting a division of the family into three different clades.

Abstract

Quotations are a means to report a broad range of events in addition to speech, and often involve both vocal and bodily demonstration. The present study examined the use of quotation to report a variety of multisensory events (i.e., containing salient visible and audible elements) as participants watched and then described a set of video clips including human speech and animal vocalizations. We examined the relationship between demonstrations conveyed through the vocal versus bodily modality, comparing them across four common quotation devices (be like, go, say, and zero quotatives), as well as across direct and non-direct quotations and retellings. We found that direct quotations involved high levels of both vocal and bodily demonstration, while non-direct quotations involved lower levels in both these channels. In addition, there was a strong positive correlation between vocal and bodily demonstration for direct quotation. This result supports a Multimodal Hypothesis where information from the two channels arises from one central concept.

Abstract

Linguistic diversity, now and in the past, is widely regarded to be independent of biological changes that took place after the emergence of Homo sapiens. We show converging evidence from paleoanthropology, speech biomechanics, ethnography, and historical linguistics that labiodental sounds (such as “f” and “v”) were innovated after the Neolithic. Changes in diet attributable to food-processing technologies modified the human bite from an edge-to-edge configuration to one that preserves adolescent overbite and overjet into adulthood. This change favored the emergence and maintenance of labiodentals. Our findings suggest that language is shaped not only by the contingencies of its history, but also by culturally induced changes in human biology.

Abstract

The range of linguistic structures and interactional practices associated with other-initiated repair (OIR) is surveyed for the Northern Australian language Murrinh-Patha. By drawing on a video corpus of informal Murrinh- Patha conversation, the OIR formats are compared in terms of their utility and versatility. Certain “restricted” formats have semantic properties that point to prior trouble source items. While these make the restricted repair initiators more specialised, the “open” formats are less well resourced semantically, which makes them more versatile. They tend to be used when the prior talk is potentially problematic in more ways than one. The open formats (especially thangku, “what?”) tend to solicit repair operations on each potential source of trouble, such that the resultant repair solution improves upon the troublesource turn in several ways

Abstract

We examined the contents of language-mediated prediction in toddlers by investigating the extent to which toddlers are sensitive to visual-shape representations of upcoming words. Previous studies with adults suggest limits to the degree to which information about the visual form of a referent is predicted during language comprehension in low constraint sentences. 30-month-old toddlers heard either contextually constraining sentences or contextually neutral sentences as they viewed images that were either identical or shape related to the heard target label. We observed that toddlers activate shape information of upcoming linguistic input in contextually constraining semantic contexts: Hearing a sentence context that was predictive of the target word activated perceptual information that subsequently influenced visual attention toward shape-related targets. Our findings suggest that visual shape is central to predictive language processing in toddlers.

Abstract

Humans are nature’s most intelligent and prolific users of external props and aids (such as written texts, slide-rules and software packages). Here we introduce a method for investigating how people make active use of their task environment during problem-solving and apply this approach to the non-verbal Raven Advanced Progressive Matrices test for fluid intelligence. We designed a click-and-drag version of the Raven test in which participants could create different external spatial configurations while solving the puzzles. In our first study, we observed that the click-and-drag test was better than the conventional static test at predicting academic achievement of university students. This pattern of results was partially replicated in a novel sample. Importantly, environment-altering actions were clustered in between periods of apparent inactivity, suggesting that problem-solvers were delicately balancing the execution of internal and external cognitive operations. We observed a systematic relationship between this critical phasic temporal signature and improved test performance. Our approach is widely applicable and offers an opportunity to quantitatively assess a powerful, although understudied, feature of human intelligence: our ability to use external objects, props and aids to solve complex problems.

Abstract

Rhythmic properties of spoken language such as metrical stress, that is, the alternation of strong and weak syllables, are important in speech recognition of stress-timed languages such as Dutch and English. Nineteen subjects listened passively to or discriminated actively between sequences of bisyllabic Dutch words, which started with either a weak or a strong syllable. Weak-initial words, which constitute 12% of the Dutch lexicon, evoked more negativity than strong-initial words in the interval between P2 and N400 components of the auditory event-related potential. This negativity was denoted as N325. The N325 was larger during stress discrimination than during passive listening. N325 was also larger when a weak-initial word followed sequence of strong-initial words than when it followed words with the same stress pattern. The latter difference was larger for listeners who performed well on stress discrimination. It was concluded that the N325 is probably a manifestation of the extraction of metrical stress from the acoustic signal and its transformation into task requirements.

Abstract

In recent years, neuroimaging research in cognitive neuroscience has increasingly used multivariate pattern analysis (MVPA) to investigate higher cognitive functions. Here we present DDTBOX, an open-source MVPA toolbox for electroencephalography (EEG) data. DDTBOX runs under MATLAB and is well integrated with the EEGLAB/ERPLAB and Fieldtrip toolboxes (Delorme and Makeig 2004; Lopez-Calderon and Luck 2014; Oostenveld et al. 2011). It trains support vector machines (SVMs) on patterns of event-related potential (ERP) amplitude data, following or preceding an event of interest, for classification or regression of experimental variables. These amplitude patterns can be extracted across space/electrodes (spatial decoding), time (temporal decoding), or both (spatiotemporal decoding). DDTBOX can also extract SVM feature weights, generate empirical chance distributions based on shuffled-labels decoding for group-level statistical testing, provide estimates of the prevalence of decodable information in the population, and perform a variety of corrections for multiple comparisons. It also includes plotting functions for single subject and group results. DDTBOX complements conventional analyses of ERP components, as subtle multivariate patterns can be detected that would be overlooked in standard analyses. It further allows for a more explorative search for information when no ERP component is known to be specifically linked to a cognitive process of interest. In summary, DDTBOX is an easy-to-use and open-source toolbox that allows for characterising the time-course of information related to various perceptual and cognitive processes. It can be applied to data from a large number of experimental paradigms and could therefore be a valuable tool for the neuroimaging community.

Abstract

Humans are especially good at taking another’s perspective — representing what others might be thinking or experiencing. This “mentalizing” capacity is apparent in everyday human interactions and conversations. We investigated its neural basis using magnetoencephalography. We focused on whether mentalizing was engaged spontaneously and routinely to understand an utterance’s meaning or largely on-demand, to restore "common ground" when expectations were violated. Participants conversed with 1 of 2 confederate speakers and established tacit agreements about objects’ names. In a subsequent “test” phase, some of these agreements were violated by either the same or a different speaker. Our analysis of the neural processing of test phase utterances revealed recruitment of neural circuits associated with language (temporal cortex), episodic memory (e.g., medial temporal lobe), and mentalizing (temporo-parietal junction and ventro-medial prefrontal cortex). Theta oscillations (3 - 7 Hz) were modulated most prominently, and we observed phase coupling between functionally distinct neural circuits. The episodic memory and language circuits were recruited in anticipation of upcoming referring expressions, suggesting that context-sensitive predictions were spontaneously generated. In contrast, the mentalizing areas were recruited on-demand, as a means for detecting and resolving perceived pragmatic anomalies, with little evidence they were activated to make partner-specific predictions about upcoming linguistic utterances.

Abstract

In conversation, turn transitions between speakers often occur smoothly, usually within a time window of a few hundred milliseconds. It has been argued, on the basis of a button-press experiment [De Ruiter, J. P., Mitterer, H., & Enfield, N. J. (2006). Projecting the end of a speaker's turn: A cognitive cornerstone of conversation. Language, 82(3):515–535], that participants in conversation rely mainly on lexico-syntactic information when timing and producing their turns, and that they do not need to make use of intonational cues to achieve smooth transitions and avoid overlaps. In contrast to this view, but in line with previous observational studies, our results from a dialogue task and a button-press task involving questions and answers indicate that the identification of the end of intonational phrases is necessary for smooth turn-taking. In both tasks, participants never responded to questions (i.e., gave an answer or pressed a button to indicate a turn end) at turn-internal points of syntactic completion in the absence of an intonational phrase boundary. Moreover, in the button-press task, they often pressed the button at the same point of syntactic completion when the final word of an intonational phrase was cross-spliced at that location. Furthermore, truncated stimuli ending in a syntactic completion point but lacking an intonational phrase boundary led to significantly delayed button presses. In light of these results, we argue that earlier claims that intonation is not necessary for correct turn-end projection are misguided, and that research on turn-taking should continue to consider intonation as a source of turn-end cues along with other linguistic and communicative phenomena.

Abstract

A striking puzzle about language use in everyday conversation is that turn-taking latencies are usually very short, whereas planning language production takes much longer. This implies overlap between language comprehension and production processes, but the nature and extent of such overlap has never been studied directly. Combining an interactive quiz paradigm with EEG measurements in an innovative way, we show that production planning processes start as soon as possible, that is, within half a second after the answer to a question can be retrieved (up to several seconds before the end of the question). Localization of ERP data shows early activation even of brain areas related to late stages of production planning (e.g., syllabification). Finally, oscillation results suggest an attention switch from comprehension to production around the same time frame. This perspective from interactive language use throws new light on the performance characteristics that language competence involves.

Abstract

In conversation, negative responses to invitations, requests, offers, and the like are more likely to occur with a delay – conversation analysts talk of them as dispreferred. Here we examine the contrastive cognitive load ‘yes’ and ‘no’ responses make, either when relatively fast (300 ms after question offset) or delayed (1000 ms). Participants heard short dialogues contrasting in speed and valence of response while having their EEG recorded. We found that a fast ‘no’ evokes an N400-effect relative to a fast ‘yes’; however this contrast disappeared in the delayed responses. 'No' responses however elicited a late frontal positivity both if they were fast and if they were delayed. We interpret these results as follows: a fast ‘no’ evoked an N400 because an immediate response is expected to be positive – this effect disappears as the response time lengthens because now in ordinary conversation the probability of a ‘no’ has increased. However, regardless of the latency of response, a ‘no’ response is associated with a late positivity, since a negative response is always dispreferred. Together these results show that negative responses to social actions exact a higher cognitive load, but especially when least expected, in immediate response.

Abstract

How do we decide where events begin and end? Like the ECOM clips, this questionnaire is designed to investigate how a language divides and/or integrates complex scenarios into sub-events and macro-events. The questionnaire focuses on events of motion, caused state change (e.g., breaking), and transfer (e.g., giving). It provides a checklist of scenarios that give insight into where a language “draws the line” in event integration, based on known cross-linguistic differences.

Abstract

In Yukatek Maya, event types are lexicalized in verb roots and stems that fall into a number of different form classes on the basis of (a) patterns of aspect-mood marking and (b) priviledges of undergoing valence-changing operations. Of particular interest are the intransitive classes in the light of Perlmutter’s (1978) Unaccusativity hypothesis. In the spirit of Levin & Rappaport Hovav (1995) [L&RH], Van Valin (1990), Zaenen (1993), and others, this paper investigates whether (and to what extent) the association between formal predicate classes and event types is determined by argument structure features such as ‘agentivity’ and ‘control’ or features of lexical aspect such as ‘telicity’ and ‘durativity’. It is shown that mismatches between agentivity/control and telicity/durativity are even more extensive in Yukatek than they are in English (Abusch 1985; L&RH, Van Valin & LaPolla 1997), providing new evidence against Dowty’s (1979) reconstruction of Vendler’s (1967) ‘time schemata of verbs’ in terms of argument structure configurations. Moreover, contrary to what has been claimed in earlier studies of Yukatek (Krämer & Wunderlich 1999, Lucy 1994), neither agentivity/control nor telicity/durativity turn out to be good predictors of verb class membership. Instead, the patterns of aspect-mood marking prove to be sensitive only to the presence or absense of state change, in a way that supports the unified analysis of all verbs of gradual change proposed by Kennedy & Levin (2001). The presence or absence of ‘internal causation’ (L&RH) may motivate the semantic interpretation of transitivization operations. An explicit semantics for the valence-changing operations is proposed, based on Parsons’s (1990) Neo-Davidsonian approach.

Abstract

Landscape terms reflect the relationship between geographic reality and human cognition. Are ‘mountains’, ‘rivers, ‘lakes’ and the like universally recognised in languages as naturally salient objects to be named? The landscape subproject is concerned with the interrelation between language, cognition and geography. Specifically, it investigates issues relating to how landforms are categorised cross-linguistically as well as the characteristics of place naming.

Abstract

How do we decide where events begin and end? In some languages it makes sense to say something like Dan broke the plate, but in other languages it is necessary to treat this action as a complex scenario composed of separate stages (Dan dropped the plate and then the plate broke). This document introduces issues concerning the linguistic and cognitive representations of event complexity and integration, and provides an overview of tasks that are relevant to this topic, including the ECOM clips, the Questionnaire on Event integration, and the Questionnaire on motion lexicalisation and motion description.

Abstract

How do we decide where events begin and end? In some languages it makes sense to say something like Dan broke the plate, but in other languages it is necessary to treat this action as a complex scenario composed of separate stages (Dan dropped the plate and then the plate broke). The “Event Complexity” (ECOM) clips are designed to explore how languages differ in dividing and/or integrating complex scenarios into sub-events and macro-events. The stimuli consist of animated clips of geometric shapes that participate in different scenarios (e.g., a circle “hits” a triangle and “breaks” it). Consultants are asked to describe the scenes, and then to comment on possible alternative descriptions.

Abstract

Alphabetic orthographies show more or less ambiguous relations between spelling and sound patterns. In transparent orthographies, like Italian, the pronunciation can be predicted from the spelling and vice versa. Opaque orthographies, like English, often display unpredictable spelling–sound correspondences. In this paper we present a computational analysis of word-initial bi-directional spelling–sound correspondences for Dutch, English, French, German, and Hungarian, stated in entropy values for various grain sizes. This allows us to position the five languages on the continuum from opaque to transparent orthographies, both in spelling-to-sound and sound-to-spelling directions. The analysis is based on metrics derived from information theory, and therefore independent of any specific theory of visual word recognition as well as of any specific theoretical approach of orthography.

Abstract

Hierarchical predictive coding has been identified as a possible unifying principle of brain function, and recent work in cognitive neuroscience has examined how it may be affected by age–related changes. Using language comprehension as a test case, the present study aimed to dissociate age-related changes in prediction generation versus internal model adaptation following a prediction error. Event-related brain potentials (ERPs) were measured in a group of older adults (60–81 years; n = 40) as they read sentences of the form “The opposite of black is white/yellow/nice.” Replicating previous work in young adults, results showed a target-related P300 for the expected antonym (“white”; an effect assumed to reflect a prediction match), and a graded N400 effect for the two incongruous conditions (i.e. a larger N400 amplitude for the incongruous continuation not related to the expected antonym, “nice,” versus the incongruous associated condition, “yellow”). These effects were followed by a late positivity, again with a larger amplitude in the incongruous non-associated versus incongruous associated condition. Analyses using linear mixed-effects models showed that the target-related P300 effect and the N400 effect for the incongruous non-associated condition were both modulated by age, thus suggesting that age-related changes affect both prediction generation and model adaptation. However, effects of age were outweighed by the interindividual variability of ERP responses, as reflected in the high proportion of variance captured by the inclusion of by-condition random slopes for participants and items. We thus argue that – at both a neurophysiological and a functional level – the notion of general differences between language processing in young and older adults may only be of limited use, and that future research should seek to better understand the causes of interindividual variability in the ERP responses of older adults and its relation to cognitive performance.

Abstract

Disfluencies, such as uh and uhm, are known to help the listener in speech comprehension. For instance, disfluencies may elicit prediction of less accessible referents and may trigger listeners’ attention to the following word. However, recent work suggests differential processing of disfluencies in native and non-native speech. The current study investigated whether the beneficial effects of disfluencies on listeners’ attention are modulated by the (non-)native identity of the speaker. Using the Change Detection Paradigm, we investigated listeners’ recall accuracy for words presented in disfluent and fluent contexts, in native and non-native speech. We observed beneficial effects of both native and non-native disfluencies on listeners’ recall accuracy, suggesting that native and non-native disfluencies trigger listeners’ attention in a similar fashion.

Abstract

Disfluencies, like 'uh', have been shown to help listeners anticipate reference to low-frequency words. The associative account of this 'disfluency bias' proposes that listeners learn to associate disfluency with low-frequency referents based on prior exposure to non-arbitrary disfluency distributions (i.e., greater probability of low-frequency words after disfluencies). However, there is limited evidence for listeners actually tracking disfluency distributions online. The present experiments are the first to show that adult listeners, exposed to a typical or more atypical disfluency distribution (i.e., hearing a talker unexpectedly say uh before high-frequency words), flexibly adjust their predictive strategies to the disfluency distribution at hand (e.g., learn to predict high-frequency referents after disfluency). However, when listeners were presented with the same atypical disfluency distribution but produced by a non-native speaker, no adjustment was observed. This suggests pragmatic inferences can modulate distributional learning, revealing the flexibility of, and constraints on, distributional learning in incremental language comprehension.

Abstract

Speech perception involves a number of processes that deal with variation in the speech signal. One such process is normalization for speechrate: local temporal cues are perceived relative to the rate in the surrounding context. It is as yet unclear whether and how this perceptual effect interacts with higher level impressions of rate, such as a speaker’s nonnative identity. Nonnative speakers typically speak more slowly than natives, an experience that listeners take into account when explicitly judging the rate of nonnative speech. The present study investigated whether this is also reflected in implicit rate normalization. Results indicate that nonnative speech is implicitly perceived as faster than temporally-matched native speech, suggesting that the additional cognitive load of listening to an accent speeds up rate perception. Therefore, rate perception in speech is not dependent on syllable durations alone but also on the ease of processing of the temporal signal.

Abstract

During conversation, spoken utterances occur in rich acoustic contexts, including speech produced by our interlocutor(s) and speech we produced ourselves. Prosodic characteristics of the acoustic context have been known to influence speech perception in a contrastive fashion: for instance, a vowel presented in a fast context is perceived to have a longer duration than the same vowel in a slow context. Given the ubiquity of the sound of our own voice, it may be that our own speech rate - a common source of acoustic context - also influences our perception of the speech of others. Two experiments were designed to test this hypothesis. Experiment 1 replicated earlier contextual rate effects by showing that hearing pre-recorded fast or slow context sentences alters the perception of ambiguous Dutch target words. Experiment 2 then extended this finding by showing that talking at a fast or slow rate prior to the presentation of the target words also altered the perception of those words. These results suggest that between-talker variation in speech rate production may induce between-talker variation in speech perception, thus potentially explaining why interlocutors tend to converge on speech rate in dialogue settings.

Abstract

Attempts to explain children's grammatical development often assume a close initial match between units of meaning and units of form; for example, agents are said to map to sentence-subjects and actions to verbs. The meanings themselves, according to this view, are not influenced by language, but reflect children's universal non-linguistic way of understanding the world. This paper argues that, contrary to this position, meaning as it is expressed in children's early sentences is, from the beginning, organized on the basis of experience with the grammar and lexicon of a particular language. As a case in point, children learning English and Korean are shown to express meanings having to do with directed motion according to language-specific principles of semantic and grammatical structuring from the earliest stages of word combination.

Abstract

How similar are the event concepts encoded by different languages? So far, few event domains have been investigated in any detail. The PUT project extends the systematic cross-linguistic exploration of event categorisation to a new domain, that of placement events (putting things in places and removing them from places). The goal of this task is to explore cross-linguistic universality and variability in the semantic categorisation of placement events (e.g., ‘putting a cup on the table’).

Abstract

his study investigates the interaction between surface and colour knowledge information during object recognition. In two different experiments, participants were instructed to decide whether two presented stimuli belonged to the same object identity. On the non-matching trials, we manipulated the shape and colour knowledge information activated by the two stimuli by creating four different stimulus pairs: (1) similar in shape and colour (e.g. TOMATO–APPLE); (2) similar in shape and dissimilar in colour (e.g. TOMATO–COCONUT); (3) dissimilar in shape and similar in colour (e.g. TOMATO–CHILI PEPPER) and (4) dissimilar in both shape and colour (e.g. TOMATO–PEANUT). The object pictures were presented in typical and atypical colours and also in black-and-white. The interaction between surface and colour knowledge showed to be contingent upon shape information: while colour knowledge is more important for recognising structurally similar shaped objects, surface colour is more prominent for recognising structurally dissimilar shaped objects.

Abstract

This study investigated pronunciation variants of word-final obstruent-liquid-schwa (OLS) clusters in casual French and the variables predicting the absence of the phonemes in these clusters. In a dataset of 291 noun tokens extracted from a corpus of casual conversations, we observed that in 80.7% of the tokens, at least one phoneme was absent and that in no less than 15.5% the whole cluster was absent (e.g., /mis/ for ministre). Importantly, the probability of a phoneme being absent was higher if the following phoneme was absent as well. These data show that reduction can affect several phonemes at once and is not restricted to just a handful of (function) words. Moreover, our results demonstrate that the absence of each single phoneme is affected by the speaker's tendency to increase ease of articulation and to adapt a word's pronunciation variant to the time available.

Abstract

It has been fifty years since Levelt’s monograph On Binocular Rivalry (1965) was published, but its four propositions that describe the relation between stimulus strength and the phenomenology of binocular rivalry remain a benchmark for theorists and experimentalists even today. In this review, we will revisit the original conception of the four propositions and the scientific landscape in which this happened. We will also provide a brief update concerning distributions of dominance durations, another aspect of Levelt’s monograph that has maintained a prominent presence in the field. In a critical evaluation of Levelt’s propositions against current knowledge of binocular rivalry we will then demonstrate that the original propositions are not completely compatible with what is known today, but that they can, in a straightforward way, be modified to encapsulate the progress that has been made over the past fifty years. The resulting modified, propositions are shown to apply to a broad range of bistable perceptual phenomena, not just binocular rivalry, and they allow important inferences about the underlying neural systems. We argue that these inferences reflect canonical neural properties that play a role in visual perception in general, and we discuss ways in which future research can build on the work reviewed here to attain a better understanding of these properties

Abstract

Interference in picture naming occurs from representing a partner's preparations to speak (Gambi, van de Cavey, & Pickering, 2015). We tested the origins of this interference using a simple non-communicative joint naming task based on Gambi et al. (2015), where response latencies indexed interference from partner task and partner speech content, and eye fixations to partner objects indexed overt attention. Experiment 1 contrasted a partner-present condition with a control partner-absent condition to establish the role of the partner in eliciting interference. For latencies, we observed interference from the partner's task and speech content, with interference increasing due to partner task in the partner-present condition. Eye-tracking measures showed that interference in naming was not due to overt attention to partner stimuli but to broad expectations about likely utterances. Experiment 2 examined whether an equivalent non-verbal task also elicited interference, as predicted from a language as joint action framework. We replicated the finding of interference due to partner task and again found no relationship between overt attention and interference. These results support Gambi et al. (2015). Individuals co-represent a partner's task while speaking, and doing so does not require overt attention to partner stimuli.

Abstract

Existing work shows that readers often interpret grammatical errors (e.g., The key to the cabinets *were shiny) and sentence-level blends (“without-blend”: Claudia left without her headphones *off) in a non-literal fashion, inferring that a more frequent or more canonical utterance was intended instead. This work examines how interlocutor identity affects the processing and interpretation of anomalous sentences. We presented anomalies in the context of “emails” attributed to various writers in a self-paced reading paradigm and used comprehension questions to probe how sentence interpretation changed based upon properties of the item and properties of the “speaker.” Experiment 1 compared standardised American English speakers to L2 English speakers; Experiment 2 compared the same standardised English speakers to speakers of a non-Standardised American English dialect. Agreement errors and without-blends both led to more non-literal responses than comparable canonical items. For agreement errors, more non-literal interpretations also occurred when sentences were attributed to speakers of Standardised American English than either non-Standardised group. These data suggest that understanding sentences relies on expectations and heuristics about which utterances are likely. These are based upon experience with language, with speaker-specific differences, and upon more general cognitive biases.

Abstract

Computation in neuronal assemblies is putatively reflected in the excitatory and inhibitory cycles of activation distributed throughout the brain. In speech and language processing, coordination of these cycles resulting in phase synchronization has been argued to reflect the integration of information on different timescales (e.g. segmenting acoustics signals to phonemic and syllabic representations; (Giraud and Poeppel 2012 Nat. Neurosci.15, 511 (doi:10.1038/nn.3063)). A natural extension of this claim is that phase synchronization functions similarly to support the inference of more abstract higher-level linguistic structures (Martin 2016 Front. Psychol.7, 120; Martin and Doumas 2017 PLoS Biol. 15, e2000663 (doi:10.1371/journal.pbio.2000663); Martin and Doumas. 2019 Curr. Opin. Behav. Sci.29, 77–83 (doi:10.1016/j.cobeha.2019.04.008)). Hale et al. (Hale et al. 2018 Finding syntax in human encephalography with beam search. arXiv 1806.04127 (http://arxiv.org/abs/1806.04127)) showed that syntactically driven parsing decisions predict electroencephalography (EEG) responses in the time domain; here we ask whether phase synchronization in the form of either inter-trial phrase coherence or cross-frequency coupling (CFC) between high-frequency (i.e. gamma) bursts and lower-frequency carrier signals (i.e. delta, theta), changes as the linguistic structures of compositional meaning (viz., bracket completions, as denoted by the onset of words that complete phrases) accrue. We use a naturalistic story-listening EEG dataset from Hale et al. to assess the relationship between linguistic structure and phase alignment. We observe increased phase synchronization as a function of phrase counts in the delta, theta, and gamma bands, especially for function words. A more complex pattern emerged for CFC as phrase count changed, possibly related to the lack of a one-to-one mapping between ‘size’ of linguistic structure and frequency band—an assumption that is tacit in recent frameworks. These results emphasize the important role that phase synchronization, desynchronization, and thus, inhibition, play in the construction of compositional meaning by distributed neural networks in the brain.

Abstract

This study investigates cross-language lexical competition in the bilingual mental lexicon. It provides evidence for the occurrence of inhibition as well as the commonly reported facilitation during the production of cognates (words with similar phonological form and meaning in two languages) in a mixed picture naming task by highly proficient Welsh-English bilinguals. Previous studies have typically found cognate facilitation. It has previously been proposed (with respect to non-cognates) that cross-language inhibition is limited to low-proficient bilinguals; therefore, we tested highly proficient, early bilinguals. In a mixed naming experiment (i.e., picture naming with language switching), 48 highly proficient, early Welsh-English bilinguals named pictures in Welsh and English, including cognate and non-cognate targets. Participants were English-dominant, Welsh-dominant, or had equal language dominance. The results showed evidence for cognate inhibition in two ways. First, both facilitation and inhibition were found on the cognate trials themselves, compared to non-cognate controls, modulated by the participants' language dominance. The English-dominant group showed cognate inhibition when naming in Welsh (and no difference between cognates and controls when naming in English), and the Welsh-dominant and equal dominance groups generally showed cognate facilitation. Second, cognate inhibition was found as a behavioral adaptation effect, with slower naming for non-cognate filler words in trials after cognates than after non-cognate controls. This effect was consistent across all language dominance groups and both target languages, suggesting that cognate production involved cognitive control even if this was not measurable in the cognate trials themselves. Finally, the results replicated patterns of symmetrical switch costs, as commonly reported for balanced bilinguals. We propose that cognate processing might be affected by two different processes, namely competition at the lexical-semantic level and facilitation at the word form level, and that facilitation at the word form level might (sometimes) outweigh any effects of inhibition at the lemma level. In sum, this study provides evidence that cognate naming can cause costs in addition to benefits. The finding of cognate inhibition, particularly for the highly proficient bilinguals tested, provides strong evidence for the occurrence of lexical competition across languages in the bilingual mental lexicon.

Abstract

The aim of the present study was to investigate whether speech-in-speech recognition is affected by variation in the target-background timing relationship. Specifically, we examined whether within trial synchronous or asynchronous onset and offset of the target and background speech influenced speech-in-speech recognition. Native English listeners were presented with English target sentences in the presence of English or Dutch background speech. Importantly, only the short-term temporal context –in terms of onset and offset synchrony or asynchrony of the target and background speech– varied across conditions. Participants’ task was to repeat back the English target sentences. The results showed an effect of synchronicity for English-in-English but not for English-in-Dutch recognition, indicating that familiarity with the English background lead in the asynchronous English-in-English condition might have attracted attention towards the English background. Overall, this study demonstrated that speech-in-speech recognition is sensitive to the target-background timing relationship, revealing an important role for variation in the local context of the target-background relationship as it extends beyond the limits of the time-frame of the to-be-recognized target sentence.

Abstract

This study examined the temporal dynamics of spoken word recognition in noise and background speech. In two visual-world experiments, English participants listened to target words while looking at four pictures on the screen: a target (e.g. candle), an onset competitor (e.g. candy), a rhyme competitor (e.g. sandal), and an unrelated distractor (e.g. lemon). Target words were presented in quiet, mixed with broadband noise, or mixed with background speech. Results showed that lexical competition changes throughout the observation window as a function of what is presented in the background. These findings suggest that, rather than being strictly sequential, stream segregation and lexical competition interact during spoken word recognition

Abstract

How are events framed in narrative? Speakers of English (a 'satellite-framed' language), when 'reading' Mercer Mayer's wordless picture book 'Frog, Where Are You?', find the story self-evident: a boy has a dog and a pet frog; the frog escapes and runs away; the boy and dog look for it across hill and dale, through woods and over a cliff, until they find it and return home with a baby frog child of the original pet frog. In Tzeltal, as spoken in a Mayan community in southern Mexico, the story is somewhat different, because the language structures event descriptions differently. Tzeltal is in part a 'verb-framed' language with a set of Path-encoding motion verbs, so that the bare bones of the Frog story can consist of verbs translating as 'go'/'pass by'/'ascend'/ 'descend'/ 'arrive'/'return'. But Tzeltal also has satellite-framing adverbials, grammaticized from the same set of motion verbs, which encode the direction of motion or the orientation of static arrays. Furthermore, motion is not generally encoded barebones, but vivid pictorial detail is provided by positional verbs which can describe the position of the Figure as an outcome of a motion event; motion and stasis are thereby combined in a single event description. (For example: jipot jawal "he has been thrown (by the deer) lying¬_face_upwards_spread-eagled". This paper compares the use of these three linguistic resources in frog narratives from 14 Tzeltal adults and 21 children, looks at their development in the narratives of children between the ages of 4-12, and considers the results in relation to those from Berman and Slobin's (1996) comparative study of adult and child Frog stories.

Abstract

In this paper presents evidence of the disputed existence of an electrophysiological marker for the lexical-categorical distinction between open- and closed-class words. Event-related brain potentials were recorded from the scalp while subjects read a story. Separate waveforms were computed for open- and closed-class words. Two aspects of the waveforms could be reliably related to vocabulary class. The first was an early negativity in the 230- to 350-msec epoch, with a bilateral anterior predominance. This negativity was elicited by open- and closed-class words alike, was not affected by word frequency or word length, and had an earlier peak latency for closed-class words. The second was a frontal slow negative shift in the 350- to 500-msec epoch, largest over the left side of the scalp. This late negativity was only elicited by closed-class words. Although the early negativity cannot serve as a qualitative marker of the open- and closed-class distinction, it does reflect the earliest electrophysiological manifestation of the availability of categorical information from the mental lexicon. These results suggest that the brain honors the distinction between open- and closed-class words, in relation to the different roles that they play in on-line sentence processing.

Abstract

In reaction to the dominance of universalism in the 1970s and '80s, there have recently been a number of reappraisals of the relation between language and cognition, and the field of cognitive anthropology is flourishing in several new directions in both America and Europe. This is partly due to a renewal and re-evaluation of approaches to the question of linguistic relativity associated with Whorf, and partly to the inspiration of modern developments in cognitive science. This review briefly sketches the history of cognitive anthropology and surveys current research on both sides of the Atlantic. The focus is on assessing current directions, considering in particular, by way of illustration, recent work in cultural models and on spatial language and cognition. The review concludes with an assessment of how cognitive anthropology could contribute directly both to the broader project of cognitive science and to the anthropological study of how cultural ideas and practices relate to structures and processes of human cognition.

Abstract

This is a reprint of the Brown and Levinson 2000 article.

Abstract

This task has two parts: (i) video-taped elicitation of the range of possibilities for referring to persons and places, and (ii) observations of (first) references to persons and places in video-taped natural interaction. The goal of this task is to establish the repertoires of referential terms (and other practices) used for referring to persons and to places in particular languages and cultures, and provide examples of situated use of these kinds of referential practices in natural conversation. This data will form the basis for cross-language comparison, and for formulating hypotheses about general principles underlying the deployment of such referential terms in natural language usage.

Abstract

Interaction, for all that it has an ethological base, is culturally constituted, and how new social members are enculturated into the interactional practices of the society is of critical interest to our understanding of interaction – how much is learned, how variable is it across cultures – as well as to our understanding of the role of culture in children’s social-cognitive development. The goal of this task is to document the nature of caregiver infant interaction in different cultures, especially during the critical age of 9-15 months when children come to have an understanding of others’ intentions. This is of interest to all students of interaction; it does not require specialist knowledge of children.

Abstract

This is an encyclopedia entry describing conversational and interactional uses of linguistic repetition.

Abstract

This is a German translation of Brown 1980, How and why are women more polite: Some evidence from a Mayan community.

Abstract

This article is a reprint of chapter 1, the introduction to Brown and Levinson, 1987, Politeness: Some universals in language usage (Cambridge University Press).

Abstract

Speaking begins with the formulation of an intended preverbal message and linguistic encoding of this information. The transition from thought to speech occurs incrementally, with cascading planning at subsequent levels of production. In this article, we aim to specify the mechanisms that support incremental message preparation. We contrast two hypotheses about the mechanisms responsible for incorporating message-level information into a linguistic plan. According to the Initial Preparation view, messages can be encoded as fluent utterances if all information is ready before speaking begins. By contrast, on the Continuous Incrementality view, messages can be continually prepared and updated throughout the production process, allowing for fluent production even if new information is added to the message while speaking is underway. Testing these hypotheses, eye-tracked speakers in two experiments produced unscripted, conjoined noun phrases with modifiers. Both experiments showed that new message elements can be incrementally incorporated into the utterance even after articulation begins, consistent with a Continuous Incrementality view of message planning, in which messages percolate to linguistic encoding immediately as that information becomes available in the mind of the speaker. We conclude by discussing the functional role of incremental message planning in conversational speech and the situations in which this continuous incremental planning would be most likely to be observed

Abstract

Genes of the Major Histocompatibility Complex (MHC) have recently been shown to have neuronal functions in the thalamus and hippocampus. Common genetic variants in the Human Leukocyte Antigens (HLA) region, human homologue of the MHC locus, are associated with small effects on susceptibility to schizophrenia, while volumetric changes of the thalamus and hippocampus have also been linked to schizophrenia. We therefore investigated whether common variants of the HLA would affect volumetric variation of the thalamus and hippocampus. We analyzed thalamus and hippocampus volumes, as measured using structural magnetic resonance imaging, in 1.265 healthy participants. These participants had also been genotyped using genome-wide single nucleotide polymorphism (SNP) arrays. We imputed genotypes for single nucleotide polymorphisms at high density across the HLA locus, as well as HLA allotypes and HLA amino acids, by use of a reference population dataset that was specifically targeted to the HLA region. We detected a significant association of the SNP rs17194174 with thalamus volume (nominal P=0.0000017, corrected P=0.0039), as well as additional SNPs within the same region of linkage disequilibrium. This effect was largely lateralized to the left thalamus and is localized within a genomic region previously associated with schizophrenia. The associated SNPs are also clustered within a potential regulatory element, and a region of linkage disequilibrium that spans genes expressed in the thalamus, including HLA-A. Our data indicate that genetic variation within the HLA region influences the volume and asymmetry of the human thalamus. The molecular mechanisms underlying this association may relate to HLA influences on susceptibility to schizophrenia

Abstract

Speech input causes listeners to activate multiple
candidate words which then compete with one
another. These include onset competitors, that share a
beginning (bumper, butter), but also, counterintuitively,
rhyme competitors, sharing an ending
(bumper, jumper). In L1, competition is typically
stronger for onset than for rhyme. In L2, onset
competition has been attested but rhyme competition
has heretofore remained largely unexamined. We
assessed L1 (Dutch) and L2 (English) word
recognition by the same late-bilingual individuals. In
each language, eye gaze was recorded as listeners
heard sentences and viewed sets of drawings: three
unrelated, one depicting an onset or rhyme competitor
of a word in the input. Activation patterns revealed
substantial onset competition but no significant
rhyme competition in either L1 or L2. Rhyme
competition may thus be a “luxury” feature of
maximally efficient listening, to be abandoned when
resources are scarcer, as in listening by late
bilinguals, in either language.

Abstract

Under noise or speech reductions, young adult listeners flexibly adjust the parameters of lexical activation and competition to allow for speech signal unreliability. Consequently, mismatches in the input are treated more leniently such that lexical candidates are not immediately deactivated. Using eyetracking, we assessed whether this modulation of recognition dynamics also occurs for older listeners. Dutch participants (aged 60+) heard Dutch sentences containing a critical word while viewing displays of four line drawings. The name of one picture shared either onset or rhyme with the critical word (i.e., was a phonological competitor). Sentences were either clear and noise-free, or had several phonemes replaced by bursts of noise. A larger preference for onset competitors than for rhyme competitors was observed in both clear and noise conditions; performance did not alter across condition. This suggests that dynamic adjustment of spoken-word recognition parameters in response to noise is less available to older listeners.

Abstract

Several neurodevelopmental disorders are associated with preference for routine and challenging behavior following changes to routines. We examine individuals with Prader–Willi syndrome, who show elevated levels of this behavior, to better understand how previous experience of a routine can affect challenging behavior elicited by disruption to that routine. Play based challenges exposed 16 participants to routines, which were either adhered to or changed. Temper outburst behaviors, heart rate and movement were measured. As participants were exposed to routines for longer before a change (between 10 and 80 min; within participants), more temper outburst behaviors were elicited by changes. Increased emotional arousal was also elicited, which was indexed by heart rate increases not driven by movement. Further study will be important to understand whether current intervention approaches that limit exposure to changes, may benefit from the structured integration of flexibility to ensure that the opportunity for routine establishment is also limited.

Abstract

The human brain can process facial expressions of emotions rapidly and without awareness. Several studies in patients with damage to their primary visual cortices have shown that they may be able to guess the emotional expression on a face despite their cortical blindness. This non-conscious processing, called affective blindsight, may arise through an intact subcortical visual route that leads from the superior colliculus to the pulvinar, and thence to the amygdala. This pathway is thought to process the crude visual information conveyed by the low spatial frequencies of the stimuli.

In order to investigate whether this is the case, we studied a patient (TN) with bilateral cortical blindness and affective blindsight. An fMRI paradigm was performed in which fearful and neutral expressions were presented using faces that were either unfiltered, or filtered to remove high or low spatial frequencies. Unfiltered fearful faces produced right amygdala activation although the patient was unaware of the presence of the stimuli. More importantly, the low spatial frequency components of fearful faces continued to produce right amygdala activity while the high spatial frequency components did not. Our findings thus confirm that the visual information present in the low spatial frequencies is sufficient to produce affective blindsight, further suggesting that its existence could rely on the subcortical colliculo-pulvino-amygdalar pathway.

Abstract

This study examined whether musical training, ethnicity, and experience with a natural tone language influenced sensitivity to tone while listening to an artificial tone language. The language was designed with three tones, modeled after level-tone African languages. Participants listened to a 15-min random concatenation of six 3-syllable words. Sensitivity to tone was assessed using minimal pairs differing only in one syllable (nonword task: e.g., to-kà-su compared to ca-fí-to) or only in tone (tone task: e.g., to-kà-su compared to to-ká-su). Proficiency in an East Asian heritage language was the strongest predictor of success on the tone task. Asians without tone language experience were no better than other ethnic groups. We conclude by considering implications for research on second language learning, especially as approached through artificial language learning.

Abstract

Pediatric myelodysplastic syndrome (MDS) is a heterogeneous disease covering a spectrum ranging from aplasia (RCC) to myeloproliferation (RAEB(t)). In adult-type MDS there is increasing evidence for abnormal function of the bone-marrow microenvironment. Here, we extensively studied the mesenchymal stromal cells (MSCs) derived from children with MDS. MSCs were expanded from the bone-marrow of 17 MDS patients (RCC: n = 10 and advanced MDS: n = 7) and pediatric controls (n = 10). No differences were observed with respect to phenotype, differentiation capacity, immunomodulatory capacity or hematopoietic support. mRNA expression analysis by Deep-SAGE revealed increased IL-6 expression in RCC- and RAEB(t)-MDS. RCC-MDS MSC expressed increased levels of DKK3, a protein associated with decreased apoptosis. RAEB(t)-MDS revealed increased CRLF1 and decreased DAPK1 expressions. This pattern has been associated with transformation in hematopoietic malignancies. Genes reported to be differentially expressed in adult MDS-MSC did not differ between MSC of pediatric MDS and controls. An altered mRNA expression profile, associated with cell survival and malignant transformation, of MSC derived from children with MDS strengthens the hypothesis that the micro-environment is of importance in this disease. Our data support the understanding that pediatric and adult MDS are two different diseases. Further evaluation of the pathways involved might reveal additional therapy targets.

Abstract

An aberrant interaction between hematopoietic stem cells and mesenchymal stromal cells has been linked to disease and shown to contribute to the pathophysiology of hematologic malignancies in murine models. Juvenile myelomonocytic leukemia is an aggressive malignant disease affecting young infants. Here we investigated the impact of juvenile myelomonocytic leukemia on mesenchymal stromal cells. Mesenchymal stromal cells were expanded from bone marrow samples of patients at diagnosis (n=9) and after hematopoietic stem cell transplantation (n=7; from 5 patients) and from healthy children (n=10). Cells were characterized by phenotyping, differentiation, gene expression analysis (of controls and samples obtained at diagnosis) and in vitro functional studies assessing immunomodulation and hematopoietic support. Mesenchymal stromal cells from patients did not differ from controls in differentiation capacity nor did they differ in their capacity to support in vitro hematopoiesis. Deep-SAGE sequencing revealed differential mRNA expression in patient-derived samples, including genes encoding proteins involved in immunomodulation and cell-cell interaction. Selected gene expression normalized during remission after successful hematopoietic stem cell transplantation. Whereas natural killer cell activation and peripheral blood mononuclear cell proliferation were not differentially affected, the suppressive effect on monocyte to dendritic cell differentiation was increased by mesenchymal stromal cells obtained at diagnosis, but not at time of remission. This study shows that active juvenile myelomonocytic leukemia affects the immune response-related gene expression and function of mesenchymal stromal cells. In contrast, the differential gene expression of hematopoiesis-related genes could not be supported by functional data. Decreased immune surveillance might contribute to the therapy resistance and progression in juvenile myelomonocytic leukemia.

Abstract

Rapid response to danger holds an evolutionary advantage. In this positron emission tomography study, phobics were exposed to masked visual stimuli with timings that either allowed awareness or not of either phobic, fear-relevant (e.g., spiders to snake phobics), or neutral images. When the timing did not permit awareness, the amygdala responded to both phobic and fear-relevant stimuli. With time for more elaborate processing, phobic stimuli resulted in an addition of an affective processing network to the amygdala activity, whereas no activity was found in response to fear-relevant stimuli. Also, right prefrontal areas appeared deactivated, comparing aware phobic and fear-relevant conditions. Thus, a shift from top-down control to an affectively driven system optimized for speed was observed in phobic relative to fear-relevant aware processing.

Abstract

Derivational morphology is a cross-linguistically dominant mechanism for word formation, combining existing words with derivational affixes to create new word forms. However, the neurocognitive mechanisms underlying the representation and processing of such forms remain unclear. Recent cross-linguistic neuroimaging research suggests that derived words are stored and accessed as whole forms, without engaging the left-hemisphere perisylvian network associated with combinatorial processing of syntactically and inflectionally complex forms. Using fMRI with a “simple listening” no-task procedure, we reexamine these suggestions in the context of the root-based combinatorially rich Italian lexicon to clarify the role of semantic transparency (between the derived form and its stem) and affix productivity in determining whether derived forms are decompositionally represented and which neural systems are involved. Combined univariate and multivariate analyses reveal a key role for semantic transparency, modulated by affix productivity. Opaque forms show strong cohort competition effects, especially for words with nonproductive suffixes (ventura, “destiny”). The bilateral frontotemporal activity associated with these effects indicates that opaque derived words are processed as whole forms in the bihemispheric language system. Semantically transparent words with productive affixes (libreria, “bookshop”) showed no effects of lexical competition, suggesting morphologically structured co-representation of these derived forms and their stems, whereas transparent forms with nonproductive affixes (pineta, pine forest) show intermediate effects. Further multivariate analyses of the transparent derived forms revealed affix productivity effects selectively involving left inferior frontal regions, suggesting that the combinatorial and decompositional processes triggered by such forms can vary significantly across languages.

Abstract

Most people have left‐hemisphere dominance for various aspects of language processing, but only roughly 1% of the adult population has atypically reversed, rightward hemispheric language dominance (RHLD). The genetic‐developmental program that underlies leftward language laterality is unknown, as are the causes of atypical variation. We performed an exploratory whole‐genome‐sequencing study, with the hypothesis that strongly penetrant, rare genetic mutations might sometimes be involved in RHLD. This was by analogy with situs inversus of the visceral organs (left‐right mirror reversal of the heart, lungs and so on), which is sometimes due to monogenic mutations. The genomes of 33 subjects with RHLD were sequenced and analyzed with reference to large population‐genetic data sets, as well as 34 subjects (14 left‐handed) with typical language laterality. The sample was powered to detect rare, highly penetrant, monogenic effects if they would be present in at least 10 of the 33 RHLD cases and no controls, but no individual genes had mutations in more than five RHLD cases while being un‐mutated in controls. A hypothesis derived from invertebrate mechanisms of left‐right axis formation led to the detection of an increased mutation load, in RHLD subjects, within genes involved with the actin cytoskeleton. The latter finding offers a first, tentative insight into molecular genetic influences on hemispheric language dominance.

Abstract

Recent genome wide association scans (GWAS) for reading and language abilities have pin-pointed promising new candidate loci. However, the potential contributions of these loci remain to be validated. In the present study, we tested 17 of the most significantly associated single nucleotide polymorphisms (SNPs) from these GWAS studies (p < 10−6 in the original studies) in a new independent population dataset from the Netherlands: known as FIOLA (Familial Influences On Literacy Abilities). This dataset comprised 483 children from 307 nuclear families, plus 505 adults (including parents of participating children), and provided adequate statistical power to detect the effects that were previously reported. The following measures of reading and language performance were collected: word reading fluency, nonword reading fluency, phonological awareness, and rapid automatized naming. Two SNPs (rs12636438, rs7187223) were associated with performance in multivariate and univariate testing, but these did not remain significant after correction for multiple testing. Another SNP (rs482700) was only nominally associated in the multivariate test. For the rest of the SNPs we did not find supportive evidence of association. The findings may reflect differences between our study and the previous investigations in respects such as the language of testing, the exact tests used, and the recruitment criteria. Alternatively, most of the prior reported associations may have been false positives. A larger scale GWAS meta-analysis than those previously performed will likely be required to obtain robust insights into the genomic architecture underlying reading and language.

Abstract

Recent years have seen rapid technological development of devices that can record communicative behavior as participants go about daily life. This paper is intended as an end-to-end methodological guidebook for potential users of these technologies, including researchers who want to study children’s or adults’ communicative behavior in everyday contexts. We explain how long-format speech environment (LFSE) recordings provide a unique view on language use and how they can be used to complement other measures at the individual and group level. We aim to help potential users of these technologies make informed decisions regarding research design, hardware, software, and archiving. We also provide information regarding ethics and implementation, issues that are difficult to navigate for those new to this technology, and on which little or no resources are available. This guidebook offers a concise summary of information for new users and points to sources of more detailed information for more advanced users. Links to discussion groups and community-augmented databases are also provided to help readers stay up-to-date on the latest developments.