Publications

Abstract

This study investigates the time-course of information processing in both visual as well as in the auditory speech as used for word identification in face-to-face communication. It extends the limited previous research on this topic and provides a valuable database for future research in audiovisual speech perception. An evaluation of models of speech perception by ear and eye in their ability to account for the audiovisual gating data shows a superior role of the fuzzy logical model of perception (FLMP) [1] over additive models of perception. A new dynamic version of the FLMP seems to be a promising model to account for the complex interplay of perceptual and cognitive information in audiovisual spoken word recognition.

Abstract

Mutations of the epidermal growth factor receptor (EGFR) gene are found at a relatively high frequency in glioma, with the most common being the de2-7 EGFR (or EGFRvIII). This mutation arises from an in-frame deletion of exons 2–7, which removes 267 amino acids from the extracellular domain of the receptor. Despite being unable to bind ligand, the de2-7 EGFR is constitutively active at a low level. Transfection of human glioma cells with the de2-7 EGFR has little effect in vitro, but when grown as tumor xenografts this mutated receptor imparts a dramatic growth advantage. We have now mapped the phosphorylation pattern of de2-7 EGFR, both in vivo and in vitro, using a panel of antibodies unique to the different phosphorylated tyrosine residues. Phosphorylation of de2-7 EGFR was detected constitutively at all tyrosine sites surveyed both in vitro and in vivo, including tyrosine 845, a known target in the wild-type EGFR for src kinase. There was a substantial upregulation of phosphorylation at every tyrosine residue of the de2-7 EGFR when cells were grown in vivo compared to the receptor isolated from cells cultured in vitro. Upregulation of phosphorylation could be mimicked in vitro by the addition of specifi c components of the ECM such as collagen via an integrin-dependent mechanism. Since this increase in in vivo phosphorylation enhances de2-7 EGFR signaling, this observation explains why the growth enhancement mediated by de2-7 EGFR is largely restricted to the in vivo environment. In a second set of experiments we analyzed the interaction between EGFRvIII and ErbB2. Co-expression of these proteins in NR6 cells, a mouse fi broblast line devoid of ErbB family members, dramatically enhanced in vivo tumorigenicity of these cells compared to cells expressing either protein alone. Detailed analysis of these xenografts demonstrated that EGFRvIII could heterodimerize and transphosphorylate the ErbB2. Since both EGFRvIII and ErbB2 are commonly expressed at gliomas, this data suggests that the co-expression of these two proteins may enhance glioma tumorigenicity.

Abstract

Human speakers often produce sentences incrementally. They can start speaking having in mind only a fragmentary idea of what they want to say, and while saying this they refine the contents underlying subsequent parts of the utterance. This capability imposes a number of constraints on the design of a syntactic processor. This paper explores these constraints and evaluates some recent computational sentence generators from the perspective of incremental production.

Abstract

[Seven one-page psycholinguistic sketches]

Abstract

Words can be distinguished by segmental differences or by suprasegmental differences or both. Studies from English suggest that suprasegmentals play little role in human spoken-word recognition; English stress, however, is nearly always unambiguously coded in segmental structure (vowel quality); this relationship is less close in Dutch. The present study directly compared the effects of segmental and suprasegmental mispronunciation on word recognition in Dutch. There was a strong effect of suprasegmental mispronunciation, suggesting that Dutch listeners do exploit suprasegmental information in word recognition. Previous findings indicating the effects of mis-stressing for Dutch differ with stress position were replicated only when segmental change was involved, suggesting that this is an effect of segmental rather than suprasegmental processing.

Abstract

This paper examines the language-specific aspect of the TIME PASSING IS MOTION metaphor and suggests that the temporal construal of time can be influenced by a person's second language. Ahrens and Huang (2002) have analyzed the source domain of MOTION for the TIME metaphor into two special cases. In the special case one, TIME PASSING is an object that moves towards an ego. For example, qimuokao kuai dao le "the final exam is approaching." In the special case two, TIME PASSING is a point (that a plural ego is attached to) that moves across a landscape. For example, women kuai dao qimuokao le "we are approaching the final exam." In addition, in English, the ego in the special case one faces the future while in Chinese, the ego faces the past. The current experiment hypothesizes that English influences the choice of the orientation of the ego in native Chinese speakers who speak English as the second language. 54 subjects are asked to switch the clock time one hour forward. Results show that native Chinese speakers living in the Chinese speaking country tend to move the clock one hour forward to the past (92%) while native Chinese speakers living in an English speaking country are less likely to do so (60%). This implies that the experience of English influences the conceptualization of time in Mandarin Chinese.

Abstract

Originally published in Cognition International Journal of Cognitive Science, Volume 42, Numbers 1-3, 1992 This paper introduces a special issue of Cognition 011 lexical access in speech production. Over the last quarter century, the psycholinguistic study of speaking, and in particular of accessing words in speech, received a major new impetus from the analysis of speech errors, dysfluencies and hesMions, from aphasiology, and from new paradigms in reaction time research. The emerging theoretical picture partitions the accessing process into two subprocesses, the selection of an appropriate lexical item (and "lemma") from the mental lexicon, and the phonological encoding of that item, that is, the computation of a phonetic program for the item in the context of utterance These two theoretical domains are successively introduced by outlining some core issues that have been or still have to be addressed. The final section discusses the controversial question whether phonological encoding can affect lexical selection. This partitioning is also followed in this special issue as a whole. There are, first, four papers on lexical selection, then three papers on phonological encoding, and finally one on the interaction between selection and phonological encoding.

Abstract

The topic of this paper is the way in which speakers order information in discourse. I will refer to this issue with the term "linearization", and will begin with two types of general remarks. The first one concerns the scope and relevance of the problem with reference to some existing literature. The second set of general remarks will be about the place of linearization in a theory of the speaker. The following, and main part of this paper, will be a summary report of research of linearization in a limited, but well-defined domain of discourse, namely the description of spatial networks.

Abstract

Demonstratives are key items in understanding how a language constructs and interprets spatial relationships. They are also multi-functional, with applications to non-spatial deictic fields such as time, perception, person and discourse, and uses in anaphora and affect marking. This item consists of an overview of theoretical distinctions in demonstrative systems, followed by a set of practical queries and elicitation suggestions for demonstratives in “table top” space, wider spatial fields, and naturalistic data.

Abstract

The world’s languages encode a diverse range of topological relations. However, cross-linguistic investigation suggests that the relations IN, AT and ON are especially fundamental to the grammaticised expression of space. The purpose of this questionnaire is to collect information about adpositions, case markers, and spatial nominals that are involved in the expression of core IN/AT/ON meanings. The task explores the more general parts of a language’s topological system, with a view to testing certain hypotheses about the packaging of spatial concepts. The questionnaire consists of target translation sentences that focus on a number of dimensions including animacy, caused location and motion.

Abstract

Languages differ widely in terms of how they encode the fundamental concepts of location and position. For some languages, verbs have an important role to play in describing situations (e.g., whether a bottle is standing or lying on the table); for others, verbs are not used in describing location at all. This item outlines certain hypotheses concerning four “types” of languages: those that have verbless basic locatives; those that use a single verb; those that have several verbs available to express location; and those that use positional verbs. The document was originally published as an appendix to the 'Picture series for positional verbs' (https://doi.org/10.17617/2.2573831).

Abstract

Words are fundamental to reading and yet over a century of research has not masked the controversies around how words are recognized. We review some old and new research that disproves simple ideas such as words are read as wholes or are simply mapped directly to spoken language. We also review theory and research relevant to the question of sublexical influences in word recognition. We describe orthography and phonology, how they are related to each other and describe a series of new experiments on how these sources of information are processed. Tasks include lexical decision, perceptual identification, and naming. Dependent measures are reaction time, accuracy of performance, and a new measure, initial phoneme duration, that refers to the duration of the first phoneme when the target word is pronounced. Important factors in resolving the controversies include the realization that reading has multiple determinants, as well as evaluating the type of task, proper controls such as familiarity of the test items and accuracy of measurement of the response. We also address potential limitations with measures related to the mapping between orthography and phonology, and show that the existence of a sound-to-spelling consistency effect does not require interactive activation, but can be explained and predicted by a feedforward model, the Fuzzy logical model of perception.

Abstract

Dutch and Spanish differ in how predictable the stress pattern is as a function of the segmental content: it is correlated with syllable weight in Dutch but not in Spanish. In the present study, two experiments were run to compare the abilities of Dutch and Spanish speakers to separately process segmental and stress information. It was predicted that the Spanish speakers would have more difficulty focusing on the segments and ignoring the stress pattern than the Dutch speakers. The task was a speeded classification task on CVCV syllables, with blocks of trials in which the stress pattern could vary versus blocks in which it was fixed. First, we found interference due to stress variability in both languages, suggesting that the processing of segmental information cannot be performed independently of stress. Second, the effect was larger for Spanish than for Dutch, suggesting that that the degree of interference from stress variation may be partially mitigated by the predictability of stress placement in the language.

Abstract

Recent FMRI studies indicate that language related brain regions are engaged in artificial grammar (AG) processing. In the present study we investigate the Reber grammar by means of formal analysis and network simulations. We outline a new method for describing the network dynamics and propose an approach to grammar extraction based on the state-space dynamics of the network. We conclude that statistical frequency-based and rule-based acquisition procedures can be viewed as complementary perspectives on grammar learning, and more generally, that classical cognitive models can be viewed as a special case of a dynamical systems perspective on information processing