Publications

Abstract

Sentence comprehension is highly practiced and largely automatic, but this belies the complexity of the underlying processes. We used functional neuroimaging to investigate garden-path sentences that cause difficulty during comprehension, in order to unpack the different processes used to support sentence interpretation. By investigating garden-path and other types of sentences within the same individuals, we functionally profiled different regions within the temporal and frontal cortices in the left hemisphere. The results revealed that different aspects of comprehension difficulty are handled by left posterior temporal, left anterior temporal, ventral left frontal, and dorsal left frontal cortices. The functional profiles of these regions likely lie along a spectrum of specificity to generality, including language-specific processing of linguistic representations, more general conflict resolution processes operating over linguistic representations, and processes for handling difficulty in general. These findings suggest that difficulty is not unitary and that there is a role for a variety of linguistic and non-linguistic processes in supporting comprehension.

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental condition with a clear, but heterogeneous, genetic component. Germline mutations in the tumor suppressor Pten are a well-established risk factor for ASD with macrocephaly, and conditional Pten mouse models have impaired social behavior and brain development. Some mutations observed in patients disrupt the normally balanced nuclear-cytoplasmic localization of the Pten protein, and we developed the Ptenm3m4 model to study the effects of a cytoplasm-predominant Pten. In this model, germline mislocalization of Pten causes inappropriate social behavior with intact learning and memory, a profile reminiscent of high-functioning ASD. These animals also exhibit histological evidence of neuroinflammation and expansion of glial populations by 6 weeks of age. We hypothesized that the neural transcriptome of this model would be altered in a manner that could inform human idiopathic ASD, a constitutional condition. Using total RNA sequencing, we found progressive disruption of neural gene expression in Ptenm3m4 mice from 2–6 weeks of age, involving both immune and synaptic pathways. These alterations include downregulation of many highly coexpressed human ASD-susceptibility genes. Comparison with a human cortical development coexpression network revealed that genes disrupted in Ptenm3m4 mice were enriched in the same areas as those of human ASD. Although Pten-related ASD is relatively uncommon, our observations suggest that the Ptenm3m4 model recapitulates multiple molecular features of human ASD, and that Pten operates far upstream of common pathways within ASD pathogenesis.

Abstract

Peak bone mass achieved in adolescence is a determinant of bone mass in later life. In order to identify genetic variants affecting bone mineral density (BMD), we performed a genome-wide association study of BMD and related traits in 1518 children from the Avon Longitudinal Study of Parents and Children (ALSPAC). We compared results with a scan of 134 adults with high or low hip BMD. We identified associations with BMD in an area of chromosome 12 containing the Osterix (SP7) locus, a transcription factor responsible for regulating osteoblast differentiation (ALSPAC: P = 5.8 x 10(-4); Australia: P = 3.7 x 10(-4)). This region has previously shown evidence of association with adult hip and lumbar spine BMD in an Icelandic population, as well as nominal association in a UK population. A meta-analysis of these existing studies revealed strong association between SNPs in the Osterix region and adult lumbar spine BMD (P = 9.9 x 10(-11)). In light of these findings, we genotyped a further 3692 individuals from ALSPAC who had whole body BMD and confirmed the association in children as well (P = 5.4 x 10(-5)). Moreover, all SNPs were related to height in ALSPAC children, but not weight or body mass index, and when height was included as a covariate in the regression equation, the association with total body BMD was attenuated. We conclude that genetic variants in the region of Osterix are associated with BMD in children and adults probably through primary effects on growth.

Abstract

Bilinguals possess the ability of expressing themselves in more than one language, and typically do so in contextually rich and dynamic settings. Theories and models have indeed long considered context factors to affect bilingual language production in many ways. However, most experimental studies in this domain have failed to fully incorporate linguistic, social, or physical context aspects, let alone combine them in the same study. Indeed, most experimental psycholinguistic research has taken place in isolated and constrained lab settings with carefully selected words or sentences, rather than under rich and naturalistic conditions. We argue that the most influential experimental paradigms in the psycholinguistic study of bilingual language production fall short of capturing the effects of context on language processing and control presupposed by prominent models. This paper therefore aims to enrich the methodological basis for investigating context aspects in current experimental paradigms and thereby move the field of bilingual language production research forward theoretically. After considering extensions of existing paradigms proposed to address context effects, we present three far-ranging innovative proposals, focusing on virtual reality, dialog situations, and multimodality in the context of bilingual language production.

Abstract

The present study shows that [t] consonants are affected by probabilistic factors in a syllable-timed language as French, and in spontaneous as well as in journalistic speech. Study 1 showed a word bigram frequency effect in spontaneous French, but its exact nature depended on the corpus on which the probabilistic measures were based. Study 2 investigated journalistic speech and showed an effect of the joint frequency of the test word and its following word. We discuss the possibility that these probabilistic effects are due to the speaker’s planning of upcoming words, and to the speaker’s adaptation to the listener’s needs.

Abstract

This paper describes the development of a CLARIN-compatible repository solution that fulfils
both the long-term preservation requirements as well as the current day discoverability and usability
needs of an online data repository of language resources. The widely used Fedora Commons
open source repository framework, combined with the Islandora discovery layer, forms
the basis of the solution. On top of this existing solution, additional modules and tools are developed
to make it suitable for the types of data and metadata that are used by the participating
partners.

Abstract

Fluctuations in pupil size have been shown to reflect variations in processing demands during lexical and syntactic processing in language comprehension. An issue that has not received attention is whether pupil size also varies due to pragmatic manipulations. In two pupillometry experiments, we investigated whether pupil diameter was sensitive to increased processing demands as a result of comprehending an indirect request versus a direct statement. Adult participants were presented with 120 picture–sentence combinations that could be interpreted either as an indirect request (a picture of a window with the sentence “it's very hot here”) or as a statement (a picture of a window with the sentence “it's very nice here”). Based on the hypothesis that understanding indirect utterances requires additional inferences to be made on the part of the listener, we predicted a larger pupil diameter for indirect requests than statements. The results of both experiments are consistent with this expectation. We suggest that the increase in pupil size reflects additional processing demands for the comprehension of indirect requests as compared to statements. This research demonstrates the usefulness of pupillometry as a tool for experimental research in pragmatics

Abstract

Human language is extremely versatile, combining a limited set of signals in an unlimited number of ways. However, it is unknown whether conversational visual signals feed into the composite utterances with which speakers communicate their intentions. We assessed whether different combinations of visual signals lead to different intent interpretations of the same spoken utterance. Participants viewed a virtual avatar uttering spoken questions while producing single visual signals (i.e., head turn, head tilt, eyebrow raise) or combinations of these signals. After each video, participants classified the communicative intention behind the question. We found that composite utterances combining several visual signals conveyed different meaning compared to utterances accompanied by the single visual signals. However, responses to combinations of signals were more similar to the responses to related, rather than unrelated, individual signals, indicating a consistent influence of the individual visual signals on the whole. This study therefore provides first evidence for compositional, non-additive (i.e., Gestalt-like) perception of multimodal language.

Abstract

The natural ecology of language is conversation, with individuals taking turns speaking to communicate in a back-and-forth fashion. Language in this context involves strings of words that a listener must process while simultaneously planning their own next utterance. It would thus be highly advantageous if language users distributed information within an utterance in a way that may facilitate this processing–planning dynamic. While some studies have investigated how information is distributed at the level of single words or clauses, or in written language, little is known about how information is distributed within spoken utterances produced during naturalistic conversation. It also is not known how information distribution patterns of spoken utterances may differ across languages. We used a set of matched corpora (CallHome) containing 898 telephone conversations conducted in six different languages (Arabic, English, German, Japanese, Mandarin, and Spanish), analyzing more than 58,000 utterances, to assess whether there is evidence of distinct patterns of information distributions at the utterance level, and whether these patterns are similar or differed across the languages. We found that English, Spanish, and Mandarin typically show a back-loaded distribution, with higher information (i.e., surprisal) in the last half of utterances compared with the first half, while Arabic, German, and Japanese showed front-loaded distributions, with higher information in the first half compared with the last half. Additional analyses suggest that these patterns may be related to word order and rate of noun and verb usage. We additionally found that back-loaded languages have longer turn transition times (i.e.,time between speaker turns)

Abstract

Although toddlers in their 2nd year of life generally have phonologically detailed representations of words, a consistent lack of sensitivity to certain kinds of phonological changes has been reported. The origin of these insensitivities is poorly understood, and uncovering their cause is crucial for obtaining a complete picture of early phonological development. The present study explored the origins of the insensitivity to the change from coronal to labial consonants. In cross-linguistic research, we assessed to what extent this insensitivity is language-specific (or would show both in learners of Dutch and a very different language like Japanese), and contrast/direction-specific to the coronal-to-labial change (or would also extend to the coronal-to-dorsal change). We measured Dutch and Japanese 18-month-old toddlers' sensitivity to labial and dorsal mispronunciations of newly learned coronal-initial words. Both Dutch and Japanese toddlers showed reduced sensitivity to the coronal-to-labial change, although this effect was more pronounced in Dutch toddlers. The lack of sensitivity was also specific to the coronal-to-labial change because toddlers from both language backgrounds were highly sensitive to dorsal mispronunciations. Combined with results from previous studies, the present outcomes are most consistent with an early, language-general bias specific to the coronal-to-labial change, which is modified by the properties of toddlers' early, language-specific lexicon

Abstract

The majority of studies addressing psycholinguistic questions focus on speech produced and processed in a careful, laboratory speech style. This ‘careful’ speech is very different from the speech that listeners encounter in casual conversations. This article argues that research on casual speech is necessary to show the validity of conclusions based on careful speech. Moreover, research on casual speech produces new insights and questions on the processes underlying communication and on the mental lexicon that cannot be revealed by research using careful speech. This article first places research on casual speech in its historic perspective. It then provides many examples of how casual speech differs from careful speech and shows that these differences may have important implications for psycholinguistic theories. Subsequently, the article discusses the challenges that research on casual speech faces, which stem from the high variability of this speech style, its necessary casual context, and that casual speech is connected speech. We also present opportunities for research on casual speech, mostly in the form of new experimental methods that facilitate research on connected speech. However, real progress can only be made if these new methods are combined with advanced (still to be developed) statistical techniques.

Abstract

This volume presents peer-reviewed versions of papers presented at the 14th Neural Computation and Psychology Workshop (NCPW14), which took place in July 2014 at Lancaster University, UK. The workshop draws international attendees from the cutting edge of interdisciplinary
research in psychology, computational modeling, artificial intelligence and psychology, and aims to drive forward
our understanding of the mechanisms underlying a range of cognitive processes.

Abstract

Two artificial-language learning experiments directly compared English, French, and Dutch listeners’ use of suprasegmental cues for continuous-speech segmentation. In both experiments, listeners heard unbroken sequences of consonant-vowel syllables, composed of recurring three- and four-syllable “words.” These words were demarcated by(a) no cue other than transitional probabilities induced by their recurrence, (b) a consistent left-edge cue, or (c) a consistent right-edge cue. Experiment 1 examined a vowel lengthening cue. All three listener groups benefited from this cue in right-edge position; none benefited from it in left-edge position. Experiment 2 examined a pitch-movement cue. English listeners used this cue in left-edge position, French listeners used it in right-edge position, and Dutch listeners used it in both positions. These findings are interpreted as evidence of both language-universal and language-specific effects. Final lengthening is a language-universal effect expressing a more general (non-linguistic) mechanism. Pitch movement expresses prominence which has characteristically different placements across languages: typically at right edges in French, but at left edges in English and Dutch. Finally, stress realization in English versus Dutch encourages greater attention to suprasegmental variation by Dutch than by English listeners, allowing Dutch listeners to benefit from an informative pitch-movement cue even in an uncharacteristic position.

Abstract

We examined side preferences in the Florida manatee (Trichechus manatus latirostris) through observations of limb use (right and left flipper) in 123 wild and 16 captive individuals. We also analyzed archival data, the United States Geological Survey Sirenia ProjectManatee Individual Photo-identification Systemdataset, to determine lateralization of evasive action from boats. Wild and captive manatees displayed flipper lateralization at the individual, but not the population level for several behaviors including substrate touches, sculling, and feeding. In contrast, manatees were lateralized at the population level for boat-scar biases,with more manatees showing a left scar bias (45.3%) versus right (34.3%) or dorsal/ambipreferent (20.3%).

Abstract

A dominant hypothesis in empirical research on the evolution of language is the following: the fundamental difference between animal and human communication systems is captured by the distinction between regular and more complex non-regular grammars. Studies reporting successful artificial grammar learning of nested recursive structures and imaging studies of the same have methodological shortcomings since they typically allow explicit problem solving strategies and this has been shown to account for the learning effect in subsequent behavioral studies. The present study overcomes these shortcomings by using subtle violations of agreement structure in a preference classification task. In contrast to the studies conducted so far, we use an implicit learning paradigm, allowing the time needed for both abstraction processes and consolidation to take place. Our results demonstrate robust implicit learning of recursively embedded structures (context-free grammar) and recursive structures with cross-dependencies (context-sensitive grammar) in an artificial grammar learning task spanning 9 days. Keywords: Implicit artificial grammar learning; centre embedded; cross-dependency; implicit learning; context-sensitive grammar; context-free grammar; regular grammar; non-regular grammar

Abstract

The paper reports the results of a learnability experiment with German speakers, investigating the role of universal phonotactic constraints and language use in language processing. Making use of an artificial language paradigm, participants learned nonce words with existent and non-existent German final consonant clusters adhering to or violating sonority sequencing principles postulated for consonant clusters. Behavioural data and event-related brain potentials in response to these cluster properties were obtained twice, before and after learning word-picture-pairs. The results show (1) that learning and processing of final consonant clusters is facilitated by adherence to the sonority hierarchy, and (2) that actual existence of well- and ill-formed consonant clusters aids processing mechanisms. Thus, both implicit knowledge of universal phonotactic principles and frequency-based factors are demonstrated to play a role in the online-processing of words.

Abstract

Although language depends on storage and composition, just what is stored or (de)composed remains unclear. We leveraged working memory load limitations to test for composition, hypothesizing that decomposed forms should particularly tax working memory. We focused on a well-studied paradigm, English inflectional morphology. We predicted that (compositional) regulars should be harder to maintain in working memory than (non-compositional) irregulars, using a 3-back production task. Frequency, phonology, orthography, and other potentially confounding factors were controlled for. Compared to irregulars, regulars and their accompanying −s/−ing-affixed filler items yielded more errors. Underscoring the decomposition of only regulars, regulars yielded more bare-stem (e.g., walk) and stem affixation errors (walks/walking) than irregulars, whereas irregulars yielded more past-tense-form affixation errors (broughts/tolded). In line with previous evidence that regulars can be stored under certain conditions, the regular-irregular difference held specifically for phonologically consistent (not inconsistent) regulars, in particular for both low and high frequency consistent regulars in males, but only for low frequency consistent regulars in females. Sensitivity analyses suggested the findings were robust. The study further elucidates the computation of inflected forms, and introduces a simple diagnostic for linguistic composition.

Abstract

The human brain deals with the infinite variability of speech through multiple mechanisms. Some of them rely solely on information in the speech input (i.e., signal-driven) whereas some rely on linguistic or real-world knowledge (i.e., knowledge-driven). Many signal-driven perceptual processes rely on the enhancement of acoustic differences between incoming speech sounds, producing contrastive adjustments. For instance, when an ambiguous voiceless fricative is preceded by a high fundamental frequency (f0) sentence, the fricative is perceived as having lower a spectral center of gravity (CoG). However, it is not clear whether knowledge of a talker’s typical f0 can lead to similar contrastive effects. This study investigated a possible talker f0 effect on fricative CoG perception. In the exposure phase, two groups of participants (N=16 each) heard the same talker at high or low f0 for 20 minutes. Later, in the test phase, participants rated fixed-f0 /?ɔk/ tokens as being /sɔk/ (i.e., high CoG) or /ʃɔk/ (i.e., low CoG), where /?/ represents a fricative from a 5-step /s/-/ʃ/ continuum. Surprisingly, the data revealed the opposite of our contrastive hypothesis, whereby hearing high f0 instead biased perception towards high CoG. Thus, we demonstrated that talker f0 information affects fricative CoG perception.

Abstract

When monitoring the origins of their memories, people tend to mistakenly attribute mem- ories generated from internal processes (e.g., imagination, visualization) to perception. Here, we ask whether speaking a language that obligatorily encodes the source of informa- tion might help prevent such errors. We compare speakers of English to speakers of Turkish, a language that obligatorily encodes information source (direct/perceptual vs. indirect/hearsay or inference) for past events. In our experiments, participants reported having seen events that they had only inferred from post-event visual evidence. In general, error rates were higher when visual evidence that gave rise to inferences was relatively close to direct visual evidence. Furthermore, errors persisted even when participants were asked to report the specific sources of their memories. Crucially, these error patterns were equivalent across language groups, suggesting that speaking a language that obligatorily encodes source of information does not increase sensitivity to the distinction between per- ception and inference in event memory.

Abstract

It has long been recognized that language interacts with visual and spatial processes. However, the nature and extent of these interactions are widely debated. The goal of this article is to review empirical findings across several domains to understand whether language affects the way speakers conceptualize the world even when they are not speaking or understanding speech. A second goal of the present review is to shed light on the mechanisms through which effects of language are transmitted. Across domains, there is growing support for the idea that although language does not lead to long-lasting changes in mental representations, it exerts powerful influences during momentary mental computations by either modulating attention or augmenting representational power

Abstract

Although children typically comprehend the links between specific forms and their mean- ings before they produce the forms themselves, the opposite pattern also occurs. The nat- ure of these ‘reverse asymmetries’ between production and comprehension remains debated. Here we focus on a striking case where production precedes comprehension in the acquisition of Turkish evidential morphology and explore theoretical explanations of this asymmetry. We show that 3- to 6-year-old Turkish learners produce evidential mor- phemes accurately (Experiment 1) but have difficulty with evidential comprehension (Experiment 2). Furthermore, comprehension failures persist across multiple tasks (Experiments 3–4). We suggest that evidential comprehension is delayed by the develop- ment of mental perspective-taking abilities needed to compute others’ knowledge sources. In support for this hypothesis, we find that children have difficulty reasoning about others’ evidence in non-linguistic tasks but the difficulty disappears when the tasks involve accessing one’s own evidential sources (Experiment 5)

Abstract

This paper describes a new flexible delexicalization method based on glottal excited parametric speech synthesis scheme. The system utilizes inverse filtered glottal flow and all-pole modelling of the vocal tract. The method provides a possibility to retain and manipulate all relevant prosodic features of any kind of speech. Most importantly, the features include voice quality, which has not been properly modeled in earlier delexicalization methods. The functionality of the new method was tested in a prosodic tagging experiment aimed at providing word prominence data for a text-to-speech synthesis system. The experiment confirmed the usefulness of the method and further corroborated earlier evidence that linguistic factors influence the perception of prosodic prominence.

Abstract

How does the brain respond to statements that clash with a person's value system? We recorded event-related brain potentials while respondents from contrasting political-ethical backgrounds completed an attitude survey on drugs, medical ethics, social conduct, and other issues. Our results show that value-based disagreement is unlocked by language extremely rapidly, within 200 to 250 ms after the first word that indicates a clash with the reader's value system (e.g., "I think euthanasia is an acceptable/unacceptable…"). Furthermore, strong disagreement rapidly influences the ongoing analysis of meaning, which indicates that even very early processes in language comprehension are sensitive to a person's value system. Our results testify to rapid reciprocal links between neural systems for language and for valuation.

Abstract

In this chapter, I review my EEG research on comprehending sentences in context from a pragmatics-oriented perspective. The review is organized around four questions: (1) When and how do extra-sentential factors such as the prior text, identity of the speaker, or value system of the comprehender affect the incremental sentence interpretation processes indexed by the so-called N400 component of the ERP? (2) When and how do people identify the referents for expressions such as “he” or “the review”, and how do referential processes interact with sense and syntax? (3) How directly pragmatic are the interpretation-relevant ERP effects reported here? (4) Do readers and listeners anticipate upcoming information? One important claim developed in the chapter is that the well-known N400 component, although often associated with ‘semantic integration’, only indirectly reflects the sense-making involved in structure-sensitive dynamic composition of the type studied in semantics and pragmatics. According to the multiple-cause intensified retrieval (MIR) account -- essentially an extension of the memory retrieval account proposed by Kutas and colleagues -- the amplitude of the word-elicited N400 reflects the computational resources used in retrieving the relatively invariant coded meaning stored in semantic long-term memory for, and made available by, the word at hand. Such retrieval becomes more resource-intensive when the coded meanings cued by this word do not match with expectations raised by the relevant interpretive context, but also when certain other relevance signals, such as strong affective connotation or a marked delivery, indicate the need for deeper processing. The most important consequence of this account is that pragmatic modulations of the N400 come about not because the N400 at hand directly reflects a rich compositional-semantic and/or Gricean analysis to make sense of the word’s coded meaning in this particular context, but simply because the semantic and pragmatic implications of the preceding words have already been computed, and now define a less or more helpful interpretive background within which to retrieve coded meaning for the critical word.

Abstract

In normal conversation, speakers translate thoughts into words at high speed. To enable this speed, the retrieval of distinct types of linguistic knowledge has to be orchestrated with millisecond precision. The nature of this orchestration is still largely unknown. This report presents dynamic measures of the real-time activation of two basic types of linguistic knowledge, syntax and phonology. Electrophysiological data demonstrate that during noun-phrase production speakers retrieve the syntactic gender of a noun before its abstract phonological properties. This two-step process operates at high speed: the data show that phonological information is already available 40 milliseconds after syntactic properties have been retrieved.

Abstract

A not uncommon assumption in psycholinguistics is that the N400 directly indexes high-level semantic integration, the compositional, word-driven construction of sentence- and discourse-level meaning in some language-relevant unification space. The various discourse- and speaker-dependent modulations of the N400 uncovered by us and others are often taken to support this 'compositional integration' position. In my talk, I will argue that these N400 modulations are probably better interpreted as only indirectly reflecting compositional sense-making. The account that I will advance for these N400 effects is a variant of the classic Kutas and Federmeier (2002, TICS) memory retrieval account in which context effects on the word-elicited N400 are taken to reflect contextual priming of LTM access. It differs from the latter in making more explicit that the contextual cues that prime access to a word's meaning in LTM can range from very simple (e.g., a single concept) to very complex ones (e.g., a structured representation of the current discourse). Furthermore, it incorporates the possibility, suggested by recent N400 findings, that semantic retrieval can also be intensified in response to certain ‘relevance signals’, such as strong value-relevance, or a marked delivery (linguistic focus, uncommon choice of words, etc). In all, the perspective I'll draw is that in the context of discourse-level language processing, N400 effects reflect an 'overlay of technologies', with the construction of discourse-level representations riding on top of more ancient sense-making technology.

Abstract

The temporal properties of semantic and phonological processes in speech production were investigated in a new experimental paradigm using movement-related brain potentials. The main experimental task was picture naming. In addition, a 2-choice reaction go/no-go procedure was included, involving a semantic and a phonological categorization of the picture name. Lateralized readiness potentials (LRPs) were derived to test whether semantic and phonological information activated motor processes at separate moments in time. An LRP was only observed on no-go trials when the semantic (not the phonological) decision determined the response hand. Varying the position of the critical phoneme in the picture name did not affect the onset of the LRP but rather influenced when the LRP began to differ on go and no-go trials and allowed the duration of phonological encoding of a word to be estimated. These results provide electrophysiological evidence for early semantic activation and later phonological encoding.

Abstract

An introductory study of the perception of stochastically specified events is reported. The initial problem was to determine whether the perceiver can split visual input data of this kind into random and determined components. The inability of subjects to do so with the stimulus material used (a filmlike sequence of dot patterns), led to the more general question of how subjects code this kind of visual material. To meet the difficulty of defining the subjects' responses, two experiments were designed. In both, patterns were presented as a rapid sequence of dots on a screen. The patterns were more or less disturbed by “noise,” i.e. the dots did not appear exactly at their proper places. In the first experiment the response was a rating on a semantic scale, in the second an identification from among a set of alternative patterns. The results of these experiments give some insight in the coding systems adopted by the subjects. First, noise appears to be detrimental to pattern recognition, especially to patterns with little spread. Second, this shows connections with the factors obtained from analysis of the semantic ratings, e.g. easily disturbed patterns show a large drop in the semantic regularity factor, when only a little noise is added.

Abstract

This paper reports two experiments with vowels and consonants as phoneme detection targets in real words. In the first experiment, two relatively distinct vowels were compared with two confusible stop consonants. Response times to the vowels were longer than to the consonants. Response times correlated negatively with target phoneme length. In the second, two relatively distinct vowels were compared with their corresponding semivowels. This time, the vowels were detected faster than the semivowels. We conclude that response time differences between vowels and stop consonants in this task may reflect differences between phoneme categories in the variability of tokens, both in the acoustic realisation of targets and in the' representation of targets by subjects.

Abstract

The social behavior of chimpanzees has been extensively studied, yet not much is known about how they behave in response to the death of a group member. Here, we provide a detailed report of the reactions of a group of chimpanzees to finding the dead body of a 9-year-old male group member. The behavior of the group was characterized by quiet attendance and close inspections punctuated by rare displays. Moreover, the body was continuously attended and closely inspected by several adults and juveniles, including an adult male who formed a close social bond with the deceased individual after the deceased individual’s mother died 4 years earlier. When considered with observations of how chimpanzees respond to dead infants and adults in this group and in others, these observations suggest that chimpanzees’ responses to death may be mediated by social bonds with the deceased individual. The results are discussed in light of recent reports on chimpanzees’ reactions to dead community members and more general primate thanatology.

Abstract

Computer simulations in an instructional context can be characterized according to four aspects (themes): simulation models, learning goals, learning processes and learner activity. The present paper provides an outline of these four themes. The main classification criterion for simulation models is quantitative vs. qualitative models. For quantitative models a further subdivision can be made by classifying the independent and dependent variables as continuous or discrete. A second criterion is whether one of the independent variables is time, thus distinguishing dynamic and static models. Qualitative models on the other hand use propositions about non-quantitative properties of a system or they describe quantitative aspects in a qualitative way. Related to the underlying model is the interaction with it. When this interaction has a normative counterpart in the real world we call it a procedure. The second theme of learning with computer simulation concerns learning goals. A learning goal is principally classified along three dimensions, which specify different aspects of the knowledge involved. The first dimension, knowledge category, indicates that a learning goal can address principles, concepts and/or facts (conceptual knowledge) or procedures (performance sequences). The second dimension, knowledge representation, captures the fact that knowledge can be represented in a more declarative (articulate, explicit), or in a more compiled (implicit) format, each one having its own advantages and drawbacks. The third dimension, knowledge scope, involves the learning goal's relation with the simulation domain; knowledge can be specific to a particular domain, or generalizable over classes of domains (generic). A more or less separate type of learning goal refers to knowledge acquisition skills that are pertinent to learning in an exploratory environment. Learning processes constitute the third theme. Learning processes are defined as cognitive actions of the learner. Learning processes can be classified using a multilevel scheme. The first (highest) of these levels gives four main categories: orientation, hypothesis generation, testing and evaluation. Examples of more specific processes are model exploration and output interpretation. The fourth theme of learning with computer simulations is learner activity. Learner activity is defined as the ‘physical’ interaction of the learner with the simulations (as opposed to the mental interaction that was described in the learning processes). Five main categories of learner activity are distinguished: defining experimental settings (variables, parameters etc.), interaction process choices (deciding a next step), collecting data, choice of data presentation and metacontrol over the simulation.

Abstract

Style is an important aspect of literature, and stylistic deviations are sometimes labeled foregrounded, since their manner of expression deviates from the stylistic default. Russian Formalists have claimed that foregrounding increases processing demands and therefore causes slower reading – an effect called retardation. We tested this claim experimentally by having participants read short literary stories while measuring their eye movements. Our results confirm that readers indeed read slower and make more regressions towards foregrounded passages as compared to passages that are not foregrounded. A closer look, however, reveals significant individual differences in sensitivity to foregrounding. Some readers in fact do not slow down at all when reading foregrounded passages. The slowing down effect for literariness was related to a slowing down effect for high perplexity (unexpected) words: those readers who slowed down more during literary passages also slowed down more during high perplexity words, even though no correlation between literariness and perplexity existed in the stories. We conclude that individual differences play a major role in processing of literary texts and argue for accounts of literary reading that focus on the interplay between reader and text.

Abstract

The use of computer simulations in education and training can have substantial advantages over other approaches. In comparison with alternatives such as textbooks, lectures, and tutorial courseware, a simulation-based approach offers the opportunity to learn in a relatively realistic problem-solving context, to practise task performance without stress, to systematically explore both realistic and hypothetical situations, to change the time-scale of events, and to interact with simplified versions of the process or system being simulated. However, learners are often unable to cope with the freedom offered by, and the complexity of, a simulation. As a result many of them resort to an unsystematic, unproductive mode of exploration. There is evidence that simulation-based learning can be improved if the learner is supported while working with the simulation. Constructing such an instructional environment around simulations seems to run counter to the freedom the learner is allowed to in ‘stand alone’ simulations. The present article explores instructional measures that allow for an optimal freedom for the learner. An extensive discussion of learning goals brings two main types of learning goals to the fore: conceptual knowledge and operational knowledge. A third type of learning goal refers to the knowledge acquisition (exploratory learning) process. Cognitive theory has implications for the design of instructional environments around simulations. Most of these implications are quite general, but they can also be related to the three types of learning goals. For conceptual knowledge the sequence and choice of models and problems is important, as is providing the learner with explanations and minimization of error. For operational knowledge cognitive theory recommends learning to take place in a problem solving context, the explicit tracing of the behaviour of the learner, providing immediate feedback and minimization of working memory load. For knowledge acquisition goals, it is recommended that the tutor takes the role of a model and coach, and that learning takes place together with a companion. A second source of inspiration for designing instructional environments can be found in Instructional Design Theories. Reviewing these shows that interacting with a simulation can be a part of a more comprehensive instructional strategy, in which for example also prerequisite knowledge is taught. Moreover, information present in a simulation can also be represented in a more structural or static way and these two forms of presentation provoked to perform specific learning processes and learner activities by tutor controlled variations in the simulation, and by tutor initiated prodding techniques. And finally, instructional design theories showed that complex models and procedures can be taught by starting with central and simple elements of these models and procedures and subsequently presenting more complex models and procedures. Most of the recent simulation-based intelligent tutoring systems involve troubleshooting of complex technical systems. Learners are supposed to acquire knowledge of particular system principles, of troubleshooting procedures, or of both. Commonly encountered instructional features include (a) the sequencing of increasingly complex problems to be solved, (b) the availability of a range of help information on request, (c) the presence of an expert troubleshooting module which can step in to provide criticism on learner performance, hints on the problem nature, or suggestions on how to proceed, (d) the option of having the expert module demonstrate optimal performance afterwards, and (e) the use of different ways of depicting the simulated system. A selection of findings is summarized by placing them under the four themes we think to be characteristic of learning with computer simulations (see de Jong, this volume).

Abstract

Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion. © 2015 The Author(s)

Abstract

Pitch, intonation, and speech rate were analyzed in a collection of everyday speech heard by one Dutch infant between the ages of six and nine months. Components of each of these variables were measured in the speech of three adult speakers (mother, father, baby-sitter) when they addressed the infant, and when they addressed another adult. The results are in line with previously reported findings which are usually based on laboratory or prearranged settings: infant-directed speech in a natural setting exhibits more pitch variation, a larger number of simple intonation contours, and slower speech rate than does adult-directed speech.

Abstract

The linguistic category of irrealis does not show stable semantics across languages. This makes it difficult to formulate general statements about this category, and it has led some researchers to reject irrealis as a cross-linguistically valid category. In this paper we look at the semantics of the irrealis category of Yurakaré, an unclassified language spoken in central Bolivia, and compare it to irrealis semantics of a number of other languages. Languages differ with respect to the subcategories they subsume under the heading of irrealis. The variable subcategories are future tense, imperatives, negatives, and habitual aspect. We argue that the cross-linguistic variation is not random, and can be stated in terms of an implicational scale.

Abstract

Memory retrieval is an active process that can alter the content and accessibility of stored memories. Of potential relevance for educational practice are findings that memory retrieval fosters better retention than mere studying. This so-called testing effect has been demonstrated for different materials and populations, but there is limited consensus on the neurocognitive mechanisms involved. In this review, we relate cognitive accounts of the testing effect to findings from recent brain-imaging studies to identify neurocognitive factors that could explain the testing effect. Results indicate that testing facilitates later performance through several processes, including effects on semantic memory representations, the selective strengthening of relevant associations and inhibition of irrelevant associations, as well as potentiation of subsequent learning

Abstract

Memory retrieval is an active process that can alter the content and accessibility of stored memories. Of potential relevance for educational practice are findings that memory retrieval fosters better retention than mere studying. This so-called testing effect has been demonstrated for different materials and populations, but there is limited consensus on the neurocognitive mechanisms involved. In this review, we relate cognitive accounts of the testing effect to findings from recent brain-imaging studies to identify neurocognitive factors that could explain the testing effect. Results indicate that testing facilitates later performance through several processes, including effects on semantic memory representations, the selective strengthening of relevant associations and inhibition of irrelevant associations, as well as potentiation of subsequent learning.

Abstract

Addition problems can be solved by mentally manipulating quantities for which the bilateral intraparietal sulcus (IPS) is likely recruited, or by retrieving the answer directly from fact memory in which the left angular gyrus (AG) and perisylvian areas may play a role. Mental addition is usually studied with problems presented in the Arabic notation (4+2), and less so with number words (four+two) or dots (:: +·.). In the present study, we investigated how the notation of numbers influences processing during simple mental arithmetic. Twenty-five highly educated participants performed simple arithmetic while their brain activity was recorded with functional magnetic resonance imaging. To reveal the effect of number notation, arithmetic problems were presented in a non-symbolic (Dots) or symbolic (Arabic; Words) notation. Furthermore, we asked whether IPS processing during mental arithmetic is magnitude specific or of a more general, visuospatial nature. To this end, we included perception and manipulation of non-magnitude formats (Colors; unfamiliar Japanese Characters). Increased IPS activity was observed, suggesting magnitude calculations during addition of non-symbolic numbers. In contrast, there was greater activity in the AG and perisylvian areas for symbolic compared to non-symbolic addition, suggesting increased verbal fact retrieval. Furthermore, IPS activity was not specific to processing of numerical magnitude but also present for non-magnitude stimuli that required mental visuospatial processing (Color-mixing; Character-memory measured by a delayed match-to-sample task). Together, our data suggest that simple non-symbolic sums are calculated using visual imagery, whereas answers for simple symbolic sums are retrieved from verbal memory.

Abstract

Numerous studies demonstrate people associate colors with letters and numbers in systematic ways. But most of these studies rely on speakers of English, or closely related languages. This makes it difficult to know how generalizable these findings are, or what factors might underlie these associations. We investigated letter–color and number–color associations in Arabic speakers, who have a different writing system and unusual word structure compared to Standard Average European languages. We also aimed to identify grapheme–color synaesthetes (people who have conscious color experiences with letters and numbers). Participants associated colors with 28 basic Arabic letters and ten digits by typing color names that best fit each grapheme. We found language-specific principles determining grapheme–color associations. For example, the word formation process in Arabic was relevant for color associations. In addition, psycholinguistic variables, such as letter frequency and the intrinsic order of graphemes influenced associations. Contrary to previous studies we found no evidence for sounds playing a role in letter–color associations for Arabic, and only a very limited role for shape influencing color associations. These findings highlight the importance of linguistic and psycholinguistic features in cross-modal correspondences, and illustrate why it is important to play close attention to each language on its own terms in order to disentangle language-specific from universal effects

Abstract

Previous research has established that gesture observation aids learning in children. The current study examinedwhether observation of gestures (i.e. depictive and tracing gestures) differentially affected verbal and visual–spatial retention whenlearning a route and its street names. Specifically, we explored whether children (n = 97) with lower visual and verbal working-memory capacity benefited more from observing gestures as compared with children who score higher on these traits. To thisend, 11- to 13-year-old children were presented with an instructional video of a route containing no gestures, depictive gestures,tracing gestures or both depictive and tracing gestures. Results indicated that the type of observed gesture affected performance:Observing tracing gestures or both tracing and depictive gestures increased performance on route retention, while observingdepictive gestures or both depictive and tracing gestures increased performance on street name retention. These effects werenot differentially affected by working-memory capacity

Abstract

Dutch distinguishes at least four sentence types: statements and questions, the latter type being subdivided into wh-questions (beginning with a question word), yes/no-questions (with inversion of subject and finite), and declarative questions (lexico-syntactically identical to statement). Acoustically, each of these (sub)types was found to have clearly distinct global F0-patterns, as well as a characteristic distribution of final rises [1,2]. The present paper explores the separate contribution of parameters of global downtrend and size of accent-lending pitch movements versus aspects of the terminal rise to the human identification of the four sentence (sub)types, at various positions in the time-course of the utterance. The results show that interrogativity in Dutch can be identified at an early point in the utterance. However, wh-questions are not distinct from statements.

Abstract

As a preliminary to further research on musical consonance an explanatory investigation was made on the different modes of judgment of musical intervals. This was done by way of a semantic differential. Subjects rated 23 intervals against 10 scales. In a factor analysis three factors appeared: pitch, evaluation and fusion. The relation between these factors and some physical characteristics has been investigated. The scale consonant-dissonant showed to be purely evaluative (in opposition to Stumpf's theory). This evaluative connotation is not in accordance with the musicological meaning of consonance. Suggestions to account for this difference have been given.

Abstract

Jescheniak and Levelt (Jescheniak, J.-D., Levelt, W.J.M. 1994. Journal of Experimental Psychology: Learning, Memory and Cognition 20 (4), 824–843) have suggested that the speed with which native speakers of a gender-marking language retrieve the grammatical gender of a noun from their mental lexicon may depend on the recency of earlier access to that same noun's gender, as the result of a mechanism that is dedicated to facilitate gender-marked anaphoric reference to recently introduced discourse entities. This hypothesis was tested in two picture naming experiments. Recent gender access did not facilitate the production of gender-marked adjective noun phrases (Experiment 1), nor that of gender-marked definite article noun phrases (Experiment 2), even though naming times for the latter utterances were sensitive to the gender of a written distractor word superimposed on the picture to be named. This last result replicates and extends earlier gender-specific picture-word interference results (Schriefers, H. 1993. Journal of Experimental Psychology: Learning, Memory, and Cognition 19 (4), 841–850), showing that one can selectively tap into the production of grammatical gender agreement during speaking. The findings are relevant to theories of speech production and the representation of grammatical gender for that process.

Abstract

We ervaren de wereld met onze zintuigen: we zien, horen, voelen, proeven en ruiken. Deze ervaringen kunnen we met elkaar delen door middel van taal. Maar hoe doen we dat eigenlijk? Kunnen we alle zintuiglijke ervaringen even makkelijk verwoorden? En kunnen sprekers van verschillende talen allemaal hetzelfde uitdrukken? In dit artikel gaan de auteurs in op deze vragen en geven ze suggesties om in de klas met deze taal van de zintuigen aan de slag te gaan. Het is een voorbeeld van onderzoekend leren op de grens van taalonderwijs en wereldorientatie.

Abstract

Listeners require context to understand the casual pronunciation variants of words that are typical of spontaneous speech (Ernestus et al., 2002). The present study reports two auditory lexical decision experiments, investigating listeners' use of semantic contextual information in the comprehension of unreduced and reduced words. We found a strong semantic priming effect for low frequency unreduced words, whereas there was no such effect for reduced words. Word frequency was facilitatory for all words. These results show that semantic context is relevant especially for the comprehension of unreduced words, which is unexpected given the listener driven explanation of reduction in spontaneous speech.

Abstract

The seemingly effortless switching between languages and the merging of two languages into a coherent utterance is a hallmark of bilingual language processing, and reveals the flexibility of human speech and skilled cognitive control. That skill appears to be available not only to speakers when they produce language-switched utterances, but also to listeners and readers when presented with mixed language information. In this chapter, we review electrophysiological studies in which Event-Related Potentials (ERPs) are derived from recordings of brain activity to examine the neurocognitive aspects of comprehending and producing mixed language. Topics we discuss include the time course of brain activity associated with language switching between single stimuli and language switching of words embedded in a meaningful sentence context. The majority of ERP studies report that switching between languages incurs neurocognitive costs, but –more interestingly- ERP patterns differ as a function of L2 proficiency and the amount of daily experience with language switching, the direction of switching (switching into L2 is typically associated with higher switching costs than switching into L1), the type of language switching task, and the predictability of the language switch. Finally, we outline some future directions for this relatively new approach to the study of language switching.

Abstract

Mixed languages are said to be the result of a process of intertwining (e.g. Bakker & Muysken 1995, Bakker 1997), a regular process in which the grammar of one language is combined with the lexicon of another. However, the outcome of this process differs from language pair to language pair. As far as morphosyntax is concerned, people have discussed these different outcomes and the reasons for them extensively, e.g. Bakker 1997 for Michif, Mous 2003 for Ma’a, Muysken 1997a for Media Lengua and 1997b for Callahuaya. The issue of phonology, however, has not generated a large debate. This paper compares the phonological systems of the mixed languages Media Lengua, Callahuaya, Mednyj Aleut, and Michif. It will be argued that the outcome of the process of intertwining, as far as phonology is concerned, is at least partly determined by the extent to which unmixed phonological domains exist.

Abstract

Do aesthetic preferences for images of neatly organized compositions (e.g., images collected on blogs like Things Organized Neatly©) generalize across cultures? In an earlier study, focusing on stimulus and personal properties related to order and complexity, Western participants indicated their preference for one of two simultaneously presented images (100 pairs). In the current study, we compared the data of the native Dutch-speaking participants from this earlier sample (N = 356) to newly collected data from a native Chinese-speaking sample (N = 220). Overall, aesthetic preferences were quite similar across cultures. When relating preferences for each sample to ratings of order, complexity, soothingness, and fascination collected from a Western, mainly Dutch-speaking sample, the results hint at a cross-culturally consistent preference for images that Western participants rate as more ordered, but a cross-culturally diverse relation between preferences and complexity.

Abstract

thebeat is a Python package for working with temporal sequences and rhythms in the behavioral and cognitive sciences, as well as in bioacoustics. It provides functionality for creating experimental stimuli, and for visualizing and analyzing temporal data. Sequences, sounds, and experimental trials can be generated using single lines of code. thebeat contains functions for calculating common rhythmic measures, such as interval ratios, and for producing plots, such as circular histograms. thebeat saves researchers time when creating experiments, and provides the first steps in collecting widely accepted methods for use in timing research. thebeat is an open-source, on-going, and collaborative project, and can be extended for use in specialized subfields. thebeat integrates easily with the existing Python ecosystem, allowing one to combine our tested code with custom-made scripts. The package was specifically designed to be useful for both skilled and novice programmers. thebeat provides a foundation for working with temporal sequences onto which additional functionality can be built. This combination of specificity and plasticity should facilitate research in multiple research contexts and fields of study.

Abstract

Contrastive pitch accents can mark sentence elements occupying parallel roles. In “Mary kissed John, not Peter”, a pitch accent on Mary or John cues the implied syntactic role of Peter. Van der Burght, Friederici, Goucha, and Hartwigsen (2021) showed that listeners can build expectations concerning syntactic and semantic properties of upcoming words, derived from pitch accent information they heard previously. To further explore these expectations, we attempted a partial replication of the original German study in Dutch. In the experimental sentences “Yesterday, the police officer arrested the thief, not the inspector/murderer”, a pitch accent on subject or object cued the subject/object role of the ellipsis clause. Contrasting elements were additionally cued by the thematic role typicality of the nouns. Participants listened to sentences in which the ellipsis clause was omitted and selected the most plausible sentence-final noun (presented visually) via button press. Replicating the original study results, listeners based their sentence-final preference on the pitch accent information available in the sentence. However, as in the original study, individual differences between listeners were found, with some following prosodic information and others relying on a structural bias. The results complement the literature on ellipsis resolution and on interindividual variability in cue weighting.

Abstract

In order to communicate successfully, speakers have to take into account which information they share with their addressee, i.e. common ground. In the current experiment we investigated how and when common ground affects speech planning by tracking speakers’ eye movements while they played a referential communication game. We found evidence that common ground exerts an early, but incomplete effect on speech planning. In addition, we did not find longer planning times when speakers had to take common ground into account, suggesting that taking common ground into account is not necessarily an effortful process. Common ground information thus appears to act as a partial constraint on language production that is integrated flexibly and efficiently in the speech planning process.

Abstract

This study develops a single elicitation method to test the acquisition of third-person pronominal objects in 5-year-olds for 16 languages. This methodology allows us to compare the acquisition of pronominals in languages that lack object clitics (“pronoun languages”) with languages that employ clitics in the relevant context (“clitic languages”), thus establishing a robust cross-linguistic baseline in the domain of clitic and pronoun production for 5-year-olds. High rates of pronominal production are found in our results, indicating that children have the relevant pragmatic knowledge required to select a pronominal in the discourse setting involved in the experiment as well as the relevant morphosyntactic knowledge involved in the production of pronominals. It is legitimate to conclude from our data that a child who at age 5 is not able to produce any or few pronominals is a child at risk for language impairment. In this way, pronominal production can be taken as a developmental marker, provided that one takes into account certain cross-linguistic differences discussed in the article.

Abstract

Despite considerable research interest, it is still an open issue as to how morphologically complex words such as “car+s” are represented and processed in the brain. We studied the neural correlates of the processing of inflected nouns in the morphologically rich Finnish language. Previous behavioral studies in Finnish have yielded a robust inflectional processing cost, i.e., inflected words are harder to recognize than otherwise matched morphologically simple words. Theoretically this effect could stem either from decomposition of inflected words into a stem and a suffix at input level and/or from subsequent recombination at the semantic–syntactic level to arrive at an interpretation of the word. To shed light on this issue, we used magnetoencephalography to reveal the time course and localization of neural effects of morphological structure and frequency of written words. Ten subjects silently read high- and low-frequency Finnish words in inflected and monomorphemic form. Morphological complexity was accompanied by stronger and longerlasting activation of the left superior temporal cortex from 200 ms onwards. Earlier effects of morphology were not found, supporting the view that the well-established behavioral processing cost for inflected words stems from the semantic–syntactic level rather than from early decomposition. Since the effect of morphology was detected throughout the range of word frequencies employed, the majority of inflected Finnish words appears to be represented in decomposed form and only very high-frequency inflected words may acquire full-form representations.

Abstract

There is evidence from both behavior and brain activity that the way information is structured, through the use of focus, can up-regulate processing of focused constituents, likely to give prominence to the relevant aspects of the input. This is hypothesized to be universal, regardless of the different ways in which languages encode focus. In order to test this universalist hypothesis, we need to go beyond the more familiar linguistic strategies for marking focus, such as by means of intonation or specific syntactic structures (e.g., it-clefts). Therefore, in this study, we examine Makhuwa-Enahara, a Bantu language spoken in northern Mozambique, which uniquely marks focus through verbal conjugation. The participants were presented with sentences that consisted of either a semantically anomalous constituent or a semantically nonanomalous constituent. Moreover, focus on this particular constituent could be either present or absent. We observed a consistent pattern: Focused information generated a more negative N400 response than the same information in nonfocus position. This demonstrates that regardless of how focus is marked, its consequence seems to result in an upregulation of processing of information that is in focus.

Abstract

This study investigates the acquisition of post-verbal (temporal) adverbials and post-verbal negation in L2 Dutch. It is based on previous findings for L2 French that post-verbal negation poses less of a problem for L2 learners than post-verbal adverbial placement (Hawkins, Towell, Bazergui, Second Language Research 9: 189-233, 1993; Herschensohn, Minimally raising the verb issue: 325-336, Cascadilla Press, 1998). The current data show that, at first sight, Moroccan and Turkish learners of Dutch also have fewer problems with post-verbal negation than with post-verbal adverbials. However, when a distinction is made between different types of adverbials, it seems that this holds for adverbials of position such as 'today' but not for adverbials of contrast such as 'again'. To account for this difference, it is argued that different types of adverbial occupy different positions in the L2 data for reasons of scope marking. Moreover, the placement of adverbials such as 'again' interacts with the acquisition of finiteness marking (resulting in post-verbal placement), while there is no such interaction between adverbials such as 'today' and finiteness marking.

Abstract

The sortilin-related receptor 1 (SORL1) gene has been associated with increased risk for Alzheimer’s disease (AD). Rare genetic variants in the SORL1 gene have also been implicated in autosomal dominant early-onset AD (EOAD). Here we report a large-scale investigation of the contribution of genetic variability in SORL1 to EOAD in a European EOAD cohort. We performed massive parallel amplicon-based re-sequencing of the full coding region of SORL1 in 1255 EOAD patients and 1938 age- and origin-matched control individuals in the context of the European Early-Onset Dementia (EOD) consortium, originating from Belgium, Spain, Portugal, Italy, Sweden, Germany, and Czech Republic. We identified six frameshift variants and two nonsense variants that were exclusively present in patients. These mutations are predicted to result in haploinsufficiency through nonsense-mediated mRNA decay, which could be confirmed experimentally for SORL1 p.Gly447Argfs*22 observed in a Belgian EOAD patient. We observed a 1.5-fold enrichment of rare non-synonymous variants in patients (carrier frequency 8.8 %; SkatOMeta p value 0.0001). Of the 84 non-synonymous rare variants detected in the full patient/control cohort, 36 were only detected in patients. Our findings underscore a role of rare SORL1 variants in EOAD, but also show a non-negligible frequency of these variants in healthy individuals, necessitating the need for pathogenicity assays. Premature stop codons due to frameshift and nonsense variants, have so far exclusively been found in patients, and their predicted mode of action corresponds with evidence from in vitro functional studies of SORL1 in AD. © 2016, The Author(s).

Abstract

Background

The number of words children produce (expressive vocabulary) and understand (receptive vocabulary) changes rapidly during early development, partially due to genetic factors. Here, we performed a meta–genome-wide association study of vocabulary acquisition and investigated polygenic overlap with literacy, cognition, developmental phenotypes, and neurodevelopmental conditions, including attention-deficit/hyperactivity disorder (ADHD).

Methods

We studied 37,913 parent-reported vocabulary size measures (English, Dutch, Danish) for 17,298 children of European descent. Meta-analyses were performed for early-phase expressive (infancy, 15–18 months), late-phase expressive (toddlerhood, 24–38 months), and late-phase receptive (toddlerhood, 24–38 months) vocabulary. Subsequently, we estimated single nucleotide polymorphism–based heritability (SNP-h2) and genetic correlations (rg) and modeled underlying factor structures with multivariate models.

Results

Early-life vocabulary size was modestly heritable (SNP-h2 = 0.08–0.24). Genetic overlap between infant expressive and toddler receptive vocabulary was negligible (rg = 0.07), although each measure was moderately related to toddler expressive vocabulary (rg = 0.69 and rg = 0.67, respectively), suggesting a multifactorial genetic architecture. Both infant and toddler expressive vocabulary were genetically linked to literacy (e.g., spelling: rg = 0.58 and rg = 0.79, respectively), underlining genetic similarity. However, a genetic association of early-life vocabulary with educational attainment and intelligence emerged only during toddlerhood (e.g., receptive vocabulary and intelligence: rg = 0.36). Increased ADHD risk was genetically associated with larger infant expressive vocabulary (rg = 0.23). Multivariate genetic models in the ALSPAC (Avon Longitudinal Study of Parents and Children) cohort confirmed this finding for ADHD symptoms (e.g., at age 13; rg = 0.54) but showed that the association effect reversed for toddler receptive vocabulary (rg = −0.74), highlighting developmental heterogeneity.

Conclusions

The genetic architecture of early-life vocabulary changes during development, shaping polygenic association patterns with later-life ADHD, literacy, and cognition-related traits.

Abstract

Neurodevelopmental disorders that disturb speech and language are highly heritable. Isolation of the underlying genetic risk factors has been hampered by complexity of the phenotype and potentially large number of contributing genes. One exception is the identification of rare heterozygous mutations of the FOXP2 gene in a monogenic syndrome characterised by impaired sequencing of articulatory gestures, disrupting speech (developmental verbal dyspraxia, DVD), as well as multiple deficits in expressive and receptive language. The protein encoded by FOXP2 belongs to a divergent subgroup of forkhead-box transcription factors, with a distinctive DNA-binding domain and motifs that mediate hetero- and homodimerisation. FOXP1, the most closely related member of this subgroup, can directly interact with FOXP2 and is co-expressed in neural structures relevant to speech and language disorders. Moreover, investigations of songbird orthologues indicate that combinatorial actions of the two proteins may play important roles in vocal learning, leading to the suggestion that human FOXP1 should be considered a strong candidate for involvement in DVD. Thus, in this study, we screened the entire coding region of FOXP1 (exons and flanking intronic sequence) for nucleotide changes in a panel of probands used earlier to detect novel mutations in FOXP2. A non-synonymous coding change was identified in a single proband, yielding a proline-to-alanine change (P215A). However, this was also found in a random control sample. Analyses of non-coding SNP changes did not find any correlation with affection status. We conclude that FOXP1 mutations are unlikely to represent a major cause of DVD.

Abstract

Childhood syndromes disturbing language development are common and display high degrees of heritability. In most cases, the underlying genetic architecture is likely to be complex, involving multiple chromosomal loci and substantial heterogeneity, which makes it difficult to track down the crucial genomic risk factors. Investigation of rare Mendelian phenotypes offers a complementary route for unravelling key neurogenetic pathways. The value of this approach is illustrated by the discovery that heterozygous FOXP2 (where FOX is forkhead box) mutations cause an unusual monogenic disorder, characterized by problems with articulating speech along with deficits in expressive and receptive language. FOXP2 encodes a regulatory protein, belonging to the forkhead box family of transcription factors, known to play important roles in modulating gene expression in development and disease. Functional genetics using human neuronal models suggest that the different FOXP2 isoforms generated by alternative splicing have distinct properties and may act to regulate each other's activity. Such investigations have also analysed the missense and nonsense mutations found in cases of speech and language disorder, showing that they alter intracellular localization, DNA binding and transactivation capacity of the mutated proteins. Moreover, in the brains of mutant mice, aetiological mutations have been found to disrupt the synaptic plasticity of Foxp2-expressing circuitry. Finally, although mutations of FOXP2 itself are rare, the downstream networks which it regulates in the brain appear to be broadly implicated in typical forms of language impairment. Thus, through ongoing identification of regulated targets and interacting co-factors, this gene is providing the first molecular entry points into neural mechanisms that go awry in language-related disorders

Abstract

How do we individuate body parts? Here, we investigated the effect of body segmentation between hand and arm in tactile and visual perception. In a first experiment, we showed that two tactile stimuli felt farther away when they were applied across the wrist than when they were applied within a single body part (palm or forearm), indicating a “category boundary effect”. In the following experiments, we excluded two hypotheses, which attributed tactile segmentation to other, nontactile factors. In Experiment 2, we showed that the boundary effect does not arise from motor cues. The effect was reduced during a motor task involving flexion and extension movements of the wrist joint. Action brings body parts together into functional units, instead of pulling them apart. In Experiments 3 and 4, we showed that the effect does not arise from perceptual cues of visual discontinuities. We did not find any segmentation effect for the visual percept of the body in Experiment 3, nor for a neutral shape in Experiment 4. We suggest that the mental representation of the body is structured in categorical body parts delineated by joints, and that this categorical representation modulates tactile spatial perception.

Abstract

The eyebrows are used as conversational signals in face-to-face spoken interaction (Ekman, 1979). In Sign Language of the Netherlands (NGT), the eyebrows are typically furrowed in content questions, and raised in polar questions (Coerts, 1992). On the other hand, these eyebrow positions are also associated with anger and surprise, respectively, in general human communication (Ekman, 1993). This overlap in the functional load of the eyebrow positions results in a potential conflict for NGT signers when combining these functions simultaneously. In order to investigate the effect of the simultaneous realization of both functions on the eyebrow position we elicited instances of both question types with neutral affect and with various affective states. The data were coded using the Facial Action Coding System (FACS: Ekman, Friesen, & Hager, 2002) for type of brow movement as well as for intensity. FACS allows for the coding of muscle groups, which are termed Action Units (AUs) and which produce facial appearance changes. The results show that linguistic and affective functions of eyebrows may influence each other in NGT. That is, in surprised polar questions and angry content question a phonetic enhancement takes place of raising and furrowing, respectively. In the items with contrasting eyebrow movements, the grammatical and affective AUs are either blended (occur simultaneously) or they are realized sequentially. Interestingly, the absence of eyebrow raising (marked by AU 1+2) in angry polar questions, and the presence of eyebrow furrowing (realized by AU 4) in surprised content questions suggests that in general AU 4 may be phonetically stronger than AU 1 and AU 2, independent of its linguistic or affective function.

Abstract

This article addresses some of the theoretical questions, ethical considerations, and methodological decisions that guided the creation of the Kata Kolok corpus as well as the Kata Kolok child signing corpus. This discussion is relevant to the formation of prospective sign corpora that aim to portray the various sociolinguistic landscapes in which sign languages, whether rural or urban, emerge and evolve.

Abstract

In a recent series of publications (Traxler et al. J Mem Lang 39:558–592, 1998; Van Gompel et al. J Mem Lang 52:284–307, 2005; see also Van Gompel et al. (In: Kennedy, et al.(eds) Reading as a perceptual process, Oxford, Elsevier pp 621–648, 2000); Van Gompel et al. J Mem Lang 45:225–258, 2001) eye tracking data are reported showing that globally ambiguous (GA) sentences are read faster than locally ambiguous (LA) counterparts. They argue that these data rule out “constraint-based” models where syntactic and conceptual processors operate concurrently and syntactic ambiguity resolution is accomplished by competition. Such models predict the opposite pattern of reading times. However, this argument against competition is valid only in conjunction with two standard assumptions in current constraint-based models of sentence comprehension: (1) that syntactic competitions (e.g., Which is the best attachment site of the incoming constituent?) are pooled together with conceptual competitions (e.g., Which attachment site entails the most plausible meaning?), and (2) that the duration of a competition is a function of the overall (pooled) quality score obtained by each competitor. We argue that it is not necessary to abandon competition as a successful basis for explaining parsing phenomena and that the above-mentioned reading time data can be accounted for by a parallel-interactive model with conceptual and syntactic processors that do not pool their quality scores together. Within the individual linguistic modules, decision-making can very well be competition-based.

Abstract

We introduce a novel computer implementation of the Unification-Space parser (Vosse & Kempen 2000) in the form of a localist neural network whose dynamics is based on interactive activation and inhibition. The wiring of the network is determined by Performance Grammar (Kempen & Harbusch 2003), a lexicalist formalism with feature unification as binding operation. While the network is processing input word strings incrementally, the evolving shape of parse trees is represented in the form of changing patterns of activation in nodes that code for syntactic properties of words and phrases, and for the grammatical functions they fulfill. The system is capable, at least in a qualitative and rudimentary sense, of simulating several important dynamic aspects of human syntactic parsing, including garden-path phenomena and reanalysis, effects of complexity (various types of clause embeddings), fault-tolerance in case of unification failures and unknown words, and predictive parsing (expectation-based analysis, surprisal effects). English is the target language of the parser described.

Abstract

When children learn their native language, they have to deal with a confusing array of dependencies between various elements in an utterance. The dependent elements may be adjacent to one another or separated by intervening material. Prior studies suggest that nonadjacent dependencies are hard to learn when the intervening material has little variability, which may be due to a trade-off between adjacent and nonadjacent learning. In this study, we investigate the statistical learning of adjacent and nonadjacent dependencies under low intervening variability using a modified serial reaction time (SRT) task. Young adults were trained on mixed sets of materials comprising equally probable adjacent and nonadjacent dependencies. Offline tests administered after training showed better performance for adjacent than nonadjacent dependencies. However, online SRT data indicated that the participants developed sensitivity to both types of dependencies during training, with no significant differences between dependency types. The results demonstrate the value of online measures of learning and suggest that adjacent and nonadjacent learning can occur together even when there is low variability in the intervening material

Abstract

Person names and common nouns differ in how they are stored in the mental lexicon. Using event-related potentials, this study compared the integration of names and nouns into sentence contexts. Both person names and common nouns were highly related in meaning and either congruent or incongruent within the previous contexts. Name incongruence elicited an N400 effect, suggesting that people were able to rapidly retrieve the semantic meaning of names from long-term memory even when this process was mediated by person identification. Conversely, participants showed a “good enough” processing of the nouns due to their low specificity level and, thus, rich semantic associations, leading to a P600 effect. These distinctive ERP effects provide clear evidence for the distinctive semantic representations of these word categories by showing that the activation of a name’s meaning is mediated by a single connection between identity-specific information and person identity, whereas multiple connections exist between nouns and their meanings.

Abstract

While some aspects of social processing are shared between humans and other species, some aspects are not. The former seems to apply to merely tracking another's visual perspective in the world (i.e., what a conspecific can or cannot perceive), while the latter applies to perspective taking in form of mentally “embodying” another's viewpoint. Our previous behavioural research had indicated that only perspective taking, but not tracking, relies on simulating a body schema rotation into another's viewpoint. In the current study we employed Magnetoencephalography (MEG) and revealed that this mechanism of mental body schema rotation is primarily linked to theta oscillations in a wider brain network of body-schema, somatosensory and motor-related areas, with the right posterior temporo-parietal junction (pTPJ) at its core. The latter was reflected by a convergence of theta oscillatory power in right pTPJ obtained by overlapping the separately localised effects of rotation demands (angular disparity effect), cognitive embodiment (posture congruence effect), and basic body schema involvement (posture relevance effect) during perspective taking in contrast to perspective tracking. In a subsequent experiment we interfered with right pTPJ processing using dual pulse Transcranial Magnetic Stimulation (dpTMS) and observed a significant reduction of embodied processing. We conclude that right TPJ is the crucial network hub for transforming the embodied self into another's viewpoint, body and/or mind, thus, substantiating how conflicting representations between self and other may be resolved and potentially highlighting the embodied origins of high-level social cognition in general.

Abstract

Next to propositional content, speakers distribute information in their utterances in such a way that listeners can make a distinction between new (focused) and given (non-focused) information. This is referred to as information structure. We measured event-related potentials (ERPs) to explore the role of information structure in semantic processing. Following different questions in wh-question-answer pairs (e.g. What kind of vegetable did Ming buy for cooking today? /Who bought the vegetables for cooking today?), the answer sentences (e.g., Ming bought eggplant/beef to cook today.) contained a critical word, which was either semantically appropriate (eggplant) or inappropriate (beef), and either focus or non-focus. The results showed a full N400 effect only when the critical words were in focus position. In non-focus position a strongly reduced N400 effect was observed, in line with the well-known semantic illusion effect. The results suggest that information structure facilitates semantic processing by devoting more resources to focused information.

Abstract

A major principle of human brain organization is “integrating” some regions into networks while “segregating” other sets of regions into separate networks. However, little is known about the cognitive function of the integration and segregation of brain networks. Here, we examined the well-studied brain network for face processing, and asked whether the integration and segregation of the face network (FN) are related to face recognition performance. To do so, we used a voxel-based global brain connectivity method based on resting-state fMRI to characterize the within-network connectivity (WNC) and the between-network connectivity (BNC) of the FN. We found that 95.4% of voxels in the FN had a significantly stronger WNC than BNC, suggesting that the FN is a relatively encapsulated network. Importantly, individuals with a stronger WNC (i.e., integration) in the right fusiform face area were better at recognizing faces, whereas individuals with a weaker BNC (i.e., segregation) in the right occipital face area performed better in the face recognition tasks. In short, our study not only demonstrates the behavioral relevance of integration and segregation of the FN but also provides evidence supporting functional division of labor between the occipital face area and fusiform face area in the hierarchically organized FN.

Abstract

During early lactation, dairy cows have a negative energy balance since their energy demands exceed their energy intake: in this study, we aimed to investigate the association between diet and plasma metabolomics profiles and how these relate to energy unbalance of course in the early-lactation stage. Holstein-Friesian cows were randomly assigned to a glucogenic (n = 15) or lipogenic (n = 15) diet in early lactation. Blood was collected in week 2 and week 4 after calving. Plasma metabolite profiles were detected using liquid chromatography–mass spectrometry (LC-MS), and a total of 39 metabolites were identified. Two plasma metabolomic profiles were available every week for each cow. Metabolite abundance and metabolite ratios were used for the analysis using the XGboost algorithm to discriminate between diet treatment and lactation week. Using metabolite ratios resulted in better discrimination performance compared with the metabolite abundances in assigning cows to a lipogenic diet or a glucogenic diet. The quality of the discrimination of performance of lipogenic diet and glucogenic diet effects improved from 0.606 to 0.753 and from 0.696 to 0.842 in week 2 and week 4 (as measured by area under the curve, AUC), when the metabolite abundance ratios were used instead of abundances. The top discriminating ratios for diet were the ratio of arginine to tyrosine and the ratio of aspartic acid to valine in week 2 and week 4, respectively. For cows fed the lipogenic diet, choline and the ratio of creatinine to tryptophan were top features to discriminate cows in week 2 vs. week 4. For cows fed the glucogenic diet, methionine and the ratio of 4-hydroxyproline to choline were top features to discriminate dietary effects in week 2 or week 4. This study shows the added value of using metabolite abundance ratios to discriminate between lipogenic and glucogenic diet and lactation weeks in early-lactation cows when using metabolomics data. The application of this research will help to accurately regulate the nutrition of lactating dairy cows and promote sustainable agricultural development.

Abstract

Magnetic resonance spectroscopy (MRS) is the primary method that can measure the levels of metabolites in the brain in vivo. To achieve its potential in clinical usage, the reliability of the measurement requires further articulation. Although there are many studies that investigate the reliability of gamma-aminobutyric acid (GABA), comparatively few studies have investigated the reliability of other brain metabolites, such as glutamate (Glu), N-acetyl-aspartate (NAA), creatine (Cr), phosphocreatine (PCr), or myo-inositol (mI), which all play a significant role in brain development and functions. In addition, previous studies which predominately used only two measurements (two data points) failed to provide the details of the time effect (e.g., time-of-day) on MRS measurement within subjects. Therefore, in this study, MRS data located in the anterior cingulate cortex (ACC) were repeatedly recorded across 1 year leading to at least 25 sessions for each subject with the aim of exploring the variability of other metabolites by using the index coefficient of variability (CV); the smaller the CV, the more reliable the measurements. We found that the metabolites of NAA, tNAA, and tCr showed the smallest CVs (between 1.43% and 4.90%), and the metabolites of Glu, Glx, mI, and tCho showed modest CVs (between 4.26% and 7.89%). Furthermore, we found that the concentration reference of the ratio to water results in smaller CVs compared to the ratio to tCr. In addition, we did not find any time-of-day effect on the MRS measurements. Collectively, the results of this study indicate that the MRS measurement is reasonably reliable in quantifying the levels of metabolites.

Abstract

Natural, spontaneous speech (and even quite careful speech) often shows extreme reduction in many speech segments, even resulting in apparent deletion of consonants. Where the flap ([(sic)]) allophone of /t/ and /d/ is expected in American English, one frequently sees an approximant-like or even vocalic pattern, rather than a clear flap. Still, the /t/ or /d/ is usually perceived, suggesting the acoustic characteristics of a reduced flap are sufficient for perception of a consonant. This paper identifies several acoustic characteristics of reduced flaps based on previous acoustic research (size of intensity dip, consonant duration, and F4 valley) and presents phonetic identification data for continua that manipulate these acoustic characteristics of reduction. The results indicate that the most obvious types of acoustic variability seen in natural flaps do affect listeners' percept of a consonant, but not sufficiently to completely account for the percept. Listeners are affected by the acoustic characteristics of consonant reduction, but they are also very skilled at evaluating variability along the acoustic dimensions that realize reduction.

Abstract

This article addresses revitalization of a dormant language whose prospective speakers live in scattered geographical areas. In comparison to increasing the usage of an endangered language, revitalizing a dormant language (one with no living speakers) requires different methods to gain knowledge of the language. Language teaching for a dormant language with a scattered community presents different problems from other teaching situations. In this article, we discuss the types of tasks that must be accomplished for dormant-language revitalization, with particular focus on development of teaching materials. We also address the role of computer technologies, arguing that each use of technology should be evaluated for how effectively it increases fluency. We discuss methods for achieving semi-fluency for the first new speakers of a dormant language, and for spreading the language through the community.