Publications

Abstract

Listeners require context to understand the highly reduced words that occur in casual speech. The present study reports four auditory lexical decision experiments in which the role of semantic context in the comprehension of reduced versus unreduced speech was investigated. Experiments 1 and 2 showed semantic priming for combinations of unreduced, but not reduced, primes and low-frequency targets. In Experiment 3, we crossed the reduction of the prime with the reduction of the target. Results showed no semantic priming from reduced primes, regardless of the reduction of the targets. Finally, Experiment 4 showed that reduced and unreduced primes facilitate upcoming low-frequency related words equally if the interstimulus interval is extended. These results suggest that semantically related words need more time to be recognized after reduced primes, but once reduced primes have been fully (semantically) processed, these primes can facilitate the recognition of upcoming words as well as do unreduced primes.

Abstract

This study examines the prosody of focus in the Spanish of 16 Quechua-Spanish bilinguals near Cusco, Peru. Data come from a dialogue game that involved noun phrases consisting of a noun and an adjective. The questions in the game elicited broad focus, contrastive focus on the noun (non-final position) and contrastive focus on the adjective (final position). The phonetic analysis in Praat included peak alignment, peak height, local range and duration of the stressed syllable and word. The study revealed that Cusco Spanish differs from other Spanish varieties. In other Spanish varieties, contrastive focus is marked by early peak alignment, whereas broad focus involves a late peak on the non-final word. Furthermore, in other Spanish varieties contrastive focus is indicated by a higher F0 maximum, a wider local range, post-focal pitch reduction and a longer duration of the stressed syllable/word. For Cusco Spanish no phonological contrast between early and late peak alignment was found. However, peak alignment on the adjective in contrastive focus was significantly earlier than in the two other contexts. For women, similar results were found for the noun in contrastive focus. An additional prominence-lending feature marking contrastive focus concerned duration of the final word. Furthermore, the results revealed a higher F0 maximum for broad focus than for contrastive focus. The findings suggest a prosodic change, which is possibly due to contact with Quechua. The study contributes to research on information structure, prosody and contact-induced language change.

Abstract

ct For the first time, chimpanzees have been observed using tools to clean the corpse of a deceased group member. A female chimpanzee sat down at the dead body of a young male, selected a firm stem of grass, and started to intently remove debris from his teeth. This report contributes novel behaviour to the chimpanzee's ethogram, and highlights how crucial information for reconstructing the evolutionary origins of human mortuary practices may be missed by refraining from developing adequate observation techniques to capture non-human animals' death responses

Abstract

A major goal in the early years of elementary school is learning to read, a process in which children show substantial individual differences. To shed light on the underlying processes of early literacy, this study investigates the interrelations among four known precursors to literacy: phonological short-term memory, vocabulary size, rhyme awareness, and trainability in the phonological specificity of lexical representations, by means of structural equation modelling, in a group of 101 4-year-old children. Trainability in lexical specificity was assessed by teaching children pairs of new phonologically-similar words. Standardized tests of receptive vocabulary, short-term memory, and rhyme awareness were used. The best-fitting model showed that trainability in lexical specificity partially mediated between short-term memory and both vocabulary size and rhyme awareness. These results demonstrate that individual differences in the ability to learn phonologically-similar new words are related to individual differences in vocabulary size and rhyme awareness.

Abstract

The present study explored whether language-nonselective access in bilinguals occurs across word classes in a sentence context. Dutch–English bilinguals were auditorily presented with English (L2) sentences while looking at a visual world. The sentences contained interlingual homophones from distinct lexical categories (e.g., the English verb spoke, which overlaps phonologically with the Dutch noun for ghost, spook). Eye movement recordings showed that depictions of referents of the Dutch (L1) nouns attracted more visual attention than unrelated distractor pictures in sentences containing homophones. This finding shows that native language objects are activated during second language verb processing despite the structural information provided by the sentence context. Research highlights We show that native language words are activated during second language sentence processing. We tested this in a visual world setting on homophones with a different word class across languages. Fixations show that processing second language verbs activated native language nouns.

Abstract

So far, studies that investigated interference effects of post-learning processes on episodic memory consolidation in humans have used tasks involving only complex and meaningful information. Such tasks require reallocation of general or encoding-specific resources away from consolidation-relevant activities. The possibility that interference can be elicited using a task that heavily taxes our limited brain resources, but has low semantic and hippocampal related long-term memory processing demands, has never been tested. We address this question by investigating whether consolidation could persist in parallel with an active, encoding-irrelevant, minimally semantic task, regardless of its high resource demands for cognitive processing. We distinguish the impact of such a task on consolidation based on whether it engages resources that are: (1) general/executive, or (2) specific/overlapping with the encoding modality. Our experiments compared subsequent memory performance across two post-encoding consolidation periods: quiet wakeful rest and a cognitively demanding n-Back task. Across six different experiments (total N = 176), we carefully manipulated the design of the n-Back task to target general or specific resources engaged in the ongoing consolidation process. In contrast to previous studies that employed interference tasks involving conceptual stimuli and complex processing demands, we did not find any differences between n-Back and rest conditions on memory performance at delayed test, using both recall and recognition tests. Our results indicate that: (1) quiet, wakeful rest is not a necessary prerequisite for episodic memory consolidation; and (2) post-encoding cognitive engagement does not interfere with memory consolidation when task-performance has minimal semantic and hippocampally-based episodic memory processing demands. We discuss our findings with reference to resource and reactivation-led interference theories

Abstract

The generation of subject–verb agreement is a central component of grammatical encoding. It is sensitive to conceptual and grammatical influences, but the interplay between these factors is still not fully understood. We investigate how semantic integration of the subject noun phrase (‘the secretary of/with the governor’) and the Local Noun Number (‘the secretary with the governor/governors’) affect the ease of selecting the verb form. Two hypotheses are assessed: according to the notional hypothesis, integration encourages the assignment of the singular notional number to the noun phrase and facilitates the choice of the singular verb form. According to the lexical interference hypothesis, integration strengthens the competition between nouns within the subject phrase, making it harder to select the verb form when the nouns mismatch in number. In two experiments, adult speakers of Dutch completed spoken preambles (Experiment 1) or selected appropriate verb forms (Experiment 2). Results showed facilitatory effects of semantic integration (fewer errors and faster responses with increasing integration). These effects did not interact with the effects of the Local Noun Number (slower response times and higher error rates for mismatching than for matching noun numbers). The findings thus support the notional hypothesis and a model of agreement where conceptual and lexical factors independently contribute to the determination of the number of the subject noun phrase and, ultimately, the verb.

Abstract

Compared to the large body of work on lexical access, little research has been done on grammatical encoding in language production. An exception is the generation of subject-verb agreement. Here, two key findings have been reported: (1) Speakers make more agreement errors when the head and local noun of a phrase mismatch in number than when they match (e.g., the key to the cabinet(s)); and (2) this attraction effect is asymmetric, with stronger attraction for singular than for plural head nouns. Although these findings are robust, the cognitive processes leading to agreement errors and their significance for the generation of correct agreement are not fully understood. We propose that future studies of agreement, and grammatical encoding in general, may benefit from using paradigms that tightly control the variability of the lexical content of the material. We report two experiments illustrating this approach. In both of them, the experimental items featured combinations of four nouns, four color adjectives, and two prepositions. In Experiment 1, native speakers of Dutch described pictures in sentences such as the circle next to the stars is blue. In Experiment 2, they carried out a forced-choice task, where they read subject noun phrases (e.g., the circle next to the stars) and selected the correct verb-phrase (is blue or are blue) with a button press. Both experiments showed an attraction effect, with more errors after subject phrases with mismatching, compared to matching head and local nouns. This effect was stronger for singular than plural heads, replicating the attraction asymmetry. In contrast, the response times recorded in Experiment 2 showed similar attraction effects for singular and plural head nouns. These results demonstrate that critical agreement phenomena can be elicited reliably in lexically-reduced contexts. We discuss the theoretical implications of the findings and the potential and limitations of studies using lexically simple materials.

Abstract

The current study investigated the effects of phonologically related context pictures on the naming latencies of target words in Japanese and Chinese. Reading bare words in alphabetic languages has been shown to be rather immune to effects of context stimuli, even when these stimuli are presented in advance of the target word (e. g., Glaser & Dungelhoff, 1984; Roelofs, 2003). However, recently, semantic context effects of distractor pictures on the naming latencies of Japanese kanji (but not Chinese hanzi) words have been observed (Verdonschot, La Heij, & Schiller, 2010). In the present study, we further investigated this issue using phonologically related (i.e., homophonic) context pictures when naming target words in either Chinese or Japanese. We found that pronouncing bare nouns in Japanese is sensitive to phonologically related context pictures, whereas this is not the case in Chinese. The difference between these two languages is attributed to processing costs caused by multiple pronunciations for Japanese kanji.

Abstract

Theories of language production generally describe the segment as the basic unit in phonological encoding (e.g., Dell, 1988; Levelt, Roelofs, & Meyer, 1999). However, there is also evidence that such a unit might be language specific. Chen, Chen, and Dell (2002), for instance, found no effect of single segments when using a preparation paradigm. To shed more light on the functional unit of phonological encoding in Japanese, a language often described as being mora based, we report the results of 4 experiments using word reading tasks and masked priming. Experiment 1 demonstrated using Japanese kana script that primes, which overlapped in the whole mora with target words, sped up word reading latencies but not when just the onset overlapped. Experiments 2 and 3 investigated a possible role of script by using combinations of romaji (Romanized Japanese) and hiragana; again, facilitation effects were found only when the whole mora and not the onset segment overlapped. Experiment 4 distinguished mora priming from syllable priming and revealed that the mora priming effects obtained in the first 3 experiments are also obtained when a mora is part of a syllable. Again, no priming effect was found for single segments. Our findings suggest that the mora and not the segment (phoneme) is the basic functional phonological unit in Japanese language production planning.

Abstract

A major challenge in second language acquisition is to build up new vocabulary. How is it possible to identify the meaning of a new word among several possible referents? Adult learners typically use contextual information, which reduces the number of possible referents a new word can have. Alternatively, a social partner may facilitate word learning by directing the learner’s attention toward the correct new word meaning. While much is known about the role of this form of ‘joint attention’ in first language acquisition, little is known about its efficacy in second language acquisition. Consequently, we introduce and validate a novel visual word learning game to evaluate how joint attention affects the contextual learning of new words in a second language. Adult learners either acquired new words in a constant or variable sentence context by playing the game with a knowledgeable partner, or by playing the game alone on a computer. Results clearly show that participants who learned new words in social interaction (i) are faster in identifying a correct new word referent in variable sentence contexts, and (ii) temporally coordinate their behavior with a social partner. Testing the learned words in a post-learning recall or recognition task showed that participants, who learned interactively, better recognized words originally learned in a variable context. While this result may suggest that interactive learning facilitates the allocation of attention to a target referent, the differences in the performance during recognition and recall call for further studies investigating the effect of social interaction on learning performance. In summary, we provide first evidence on the role joint attention in second language learning. Furthermore, the new interactive learning game offers itself to further testing in complex neuroimaging research, where the lack of appropriate experimental set-ups has so far limited the investigation of the neural basis of adult word learning in social interaction.

Abstract

Introduction

The atlas by Heinrich Sachs (1892) provided an accurate description of the intralobar fibres of the occipital lobe, with a detailed representation of the short associative tracts connecting different parts of the lobe. Little attention has been paid to the work of Sachs since its publication. In this study, we present the results of the dissection of three hemispheres, performed according to the Klingler technique (1935). Our anatomical findings are then compared to the original description of the occipital fibres anatomy as detailed by Sachs.
Methods

Three hemispheres were dissected according to Klingler's technique (1935). Specimens were fixed in 10% formalin and frozen at −15 °C for two weeks. After defreezing, dissection of the white matter fibres was performed with blunt dissectors. Coronal sections were obtained according to the cuts originally described by Sachs. In addition, medial to lateral and lateral to medial dissection of the white matter of the occipital lobe was also performed.

Results

A network of short association fibres was demonstrated in the occipital lobe, comprising intralobar association fibres and U-shaped fibres, which are connecting neighbouring gyri. Lateral to the ventricles, longitudinal fibres of the stratum sagittale were also identified that are arranged as external and internal layers. Fibres of the forceps major were also found to be in direct contact with the ventricular walls. We were able to replicate all tracts originally described by Sachs. In addition, a previously unrecognised tract, connecting the cuneus to the lingual gyrus, was identified. This tract corresponds to the “sledge runner”, described in tractography studies.

Conclusions

The occipital lobe shows a rich network of intralobar fibres, arranged around the ventricular wall. Good concordance was observed between the Klingler dissection technique and the histological preparations of Sachs.

Abstract

The acquisition of non-modal auxiliaries has been assumed to constitute an important step in the acquisition of finiteness in Germanic languages (cf. Jordens/Dimroth 2005, Jordens 2004, Becker 2005). This paper focuses onthe role of the auxiliary hebben (>to have<) in the acquisition of Dutch as a second language. More specifically, it investigates whether learners' production of hebben is related to their acquisition of two phenomena commonly associated with finiteness, i.e., topicalization and negation. Data are presented from 16 Turkish and 36 Moroccan learners of Dutch who participated in an experiment involving production and imitation tasks. The production data suggest that learners use topicalization and post-verbal negation only after they have learned to produce the auxiliary hebben. The results from the imitation task indicate, that learners are more sensitive to topicalization and post-verbal negation in sentences with hebben than in sentences with lexical verbs. Interestingly this holds also for learners that did not show productive command of hebben in the production tasks. Thus, in general, the results of the experiment provide support for the idea that non-modal auxiliaries are crucial in the acquisition of (certain properties of) finiteness.

Abstract

This study investigates the acquisition of verb placement by Moroccan and Turkish second language (L2) learners of Dutch. Elicited production data corroborate earlier findings from L2 German that learners who do not produce auxiliaries do not raise lexical verbs over negation, whereas learners who produce auxiliaries do. Data from elicited imitation and sentence matching support this pattern and show that learners can have grammatical knowledge of auxiliary placement before they can produce auxiliaries. With lexical verbs, they do not show such knowledge. These results present further evidence for the different behavior of auxiliary and lexical verbs in early stages of L2 acquisition.

Abstract

There are many different syntactic constructions that languages can use to encode motion events. In recent decades, great advances have been made in the description and study of these syntactic constructions from languages spoken around the world (Talmy 1985, 1991, Slobin 1996, 2004). However, relatively little attention has been paid to historical change in these systems (exceptions are Vincent 1999, Dufresne, Dupuis & Tremblay 2003, Kopecka 2006 and Peyraube 2006). In this article, diachronic change of motion event encoding systems in Indo-European is investigated using the available historical–comparative data and phylogenetic comparative methods adopted from evolutionary biology. It is argued that Proto-Indo-European was not satellite-framed, as suggested by Talmy (2007) and Acedo Matellán and Mateu (2008), but had a mixed motion event encoding system, as is suggested by the available historical–comparative data

Abstract

There have been opposing views on the possibility of a relationship between motion event encoding and the size of the path verb lexicon. Özçalışkan (2004) has proposed that verb-framed and satellite-framed languages should approximately have the same number of path verbs, whereas a review of some of the literature suggests that verb-framed languages typically have a bigger path verb lexicon than satelliteframed languages. In this article I demonstrate that evidence for this correlation can be found through phylogenetic comparative analysis of parallel corpus data from twenty Indo-European languages.

Abstract

Forkhead-box protein P2 is a transcription factor that has been associated with intriguing aspects of cognitive function in humans, non-human mammals, and song-learning birds. Heterozygous mutations of the human FOXP2 gene cause a monogenic speech and language disorder. Reduced functional dosage of the mouse version (Foxp2) causes deficient cortico-striatal synaptic plasticity and impairs motor-skill learning. Moreover, the songbird orthologue appears critically important for vocal learning. Across diverse vertebrate species, this well-conserved transcription factor is highly expressed in the developing and adult central nervous system. Very little is known about the mechanisms regulated by Foxp2 during brain development. We used an integrated functional genomics strategy to robustly define Foxp2-dependent pathways, both direct and indirect targets, in the embryonic brain. Specifically, we performed genome-wide in vivo ChIP–chip screens for Foxp2-binding and thereby identified a set of 264 high-confidence neural targets under strict, empirically derived significance thresholds. The findings, coupled to expression profiling and in situ hybridization of brain tissue from wild-type and mutant mouse embryos, strongly highlighted gene networks linked to neurite development. We followed up our genomics data with functional experiments, showing that Foxp2 impacts on neurite outgrowth in primary neurons and in neuronal cell models. Our data indicate that Foxp2 modulates neuronal network formation, by directly and indirectly regulating mRNAs involved in the development and plasticity of neuronal connections

Abstract

Mutations of the human FOXP2 gene have been shown to cause severe difficulties in learning to make coordinated sequences of articulatory gestures that underlie speech (developmental verbal dyspraxia or DVD). Affected individuals are impaired in multiple aspects of expressive and receptive linguistic processing and ­display abnormal grey matter volume and functional activation patterns in cortical and subcortical brain regions. The protein encoded by FOXP2 belongs to a divergent subgroup of forkhead-box transcription factors, with a distinctive DNA-binding domain and motifs that mediate hetero- and homodimerization. This chapter describes the successful use of FOXP2 as a unique molecular window into neurogenetic pathways that are important for speech and language development, adopting several complementary strategies. These include direct functional investigations of FOXP2 splice variants and the effects of etiological mutations. FOXP2’s role as a transcription factor also enabled the development of functional genomic routes for dissecting neurogenetic mechanisms that may be relevant for speech and language. By identifying downstream target genes regulated by FOXP2, it was possible to identify common regulatory themes in modulating synaptic plasticity, neurodevelopment, and axon guidance. These targets represent novel entrypoints into in vivo pathways that may be disturbed in speech and language disorders. The identification of FOXP2 target genes has also led to the discovery of a shared neurogenetic pathway between clinically distinct language disorders; the rare Mendelian form of DVD and a complex and more common form of language ­disorder known as Specific Language Impairment.

Abstract

The fruitless gene (fru) encodes a set of transcription factors (Fru) that display sexually dimorphic gene expression in the brain of the fruit-fly;Drosophila melanogaster . Behavioural studies have demonstrated that fru isessentialforcourtshipbehaviour inthemale flyandisthoughttoact bydirectingthe development of sex-specific neural circuitry that encodes this innate behavioural response. This study reports the identification of direct regulatory targets of the sexually dimorphic isoforms of the Fru protein using an in vitro model system. Genome wide binding sites were identified for each of the isoforms using Chromatin Immunoprecipitation coupled to deep sequencing (ChIP-Seq). Putative target genes were found to be involved in processes such as neurotransmission, ion-channel signalling and neuron development. All isoforms showed asignificant bias towards genes located on the X-chromosome,which may reflect a specific role for Fru in regulating x-linked genes. Taken together with expression analysis carried out in Fru positive neurons specifically isolated from the male fly brain, it appears that the Fru protein acts as a transcriptional activator. Understanding the regulatory cascades induced by Fru will help to shed light on the molecular mechanisms that are important for specification of neural circuitry underlying complex behaviour

Abstract

Understanding the biological foundations of language is vital to gaining insight into how the capacity for language may have evolved in humans. Animal models can be exploited to learn about the biological underpinnings of shared human traits, and although no other animals display speech or language, a range of behaviors found throughout the animal kingdom are relevant to speech and spoken language. To date, such investigations have been dominated by studies of our closest primate relatives searching for shared traits, or more distantly related species that are sophisticated vocal communicators, like songbirds. Herein I make the case for turning our attention to the Chiropterans, to shed new light on the biological encoding and evolution of human language-relevant traits. Bats employ complex vocalizations to facilitate navigation as well as social interactions, and are exquisitely tuned to acoustic information. Furthermore, bats display behaviors such as vocal learning and vocal turn-taking that are directly pertinent for human spoken language. Emerging technologies are now allowing the study of bat vocal communication, from the behavioral to the neurobiological and molecular level. Although it is clear that no single animal model can reflect the complexity of human language, by comparing such findings across diverse species we can identify the shared biological mechanisms likely to have influenced the evolution of human language. Keywords

Abstract

This electrophysiological study asked whether the brain processes grammatical gender
violations in casual speech differently than in careful speech. Native speakers of Dutch were
presented with utterances that contained adjective-noun pairs in which the adjective was either
correctly inflected with a word-final schwa (e.g. een spannende roman “a suspenseful novel”) or
incorrectly uninflected without that schwa (een spannend roman). Consistent with previous
findings, the uninflected adjectives elicited an electrical brain response sensitive to syntactic
violations when the talker was speaking in a careful manner. When the talker was speaking in a
casual manner, this response was absent. A control condition showed electrophysiological responses
for carefully as well as casually produced utterances with semantic anomalies, showing that
listeners were able to understand the content of both types of utterance. The results suggest that
listeners take information about the speaking style of a talker into account when processing the
acoustic-phonetic information provided by the speech signal. Absent schwas in casual speech are
effectively not grammatical gender violations. These changes in syntactic processing are evidence
of contextually-driven neural flexibility.

Abstract

A central question in the study of the mental lexicon is how morphologically complex words are processed. We consider this question from the viewpoint of statistical models of morphology. As an indicator of the mental processing cost in the brain, we use reaction times to words in a visual lexical decision task on Finnish nouns. Statistical correlation between a model and reaction times is employed as a goodness measure of the model. In particular, we study Morfessor, an unsupervised method for learning concatenative morphology. The results for a set of inflected and monomorphemic Finnish nouns reveal that the probabilities given by Morfessor, especially the Categories-MAP version, show considerably higher correlations to the reaction times than simple word statistics such as frequency, morphological family size, or length. These correlations are also higher than when any individual test subject is viewed as a model.

Abstract

Cross-linguistically, both subjects and topical information tend to be placed at the beginning of a sentence. Subjects are generally highly topical, causing both tendencies to converge on the same word order. However, subjects that lack prototypical topic properties may give rise to an incongruence between the preference to start a sentence with the subject and the preference to start a sentence with the most accessible information. We present a corpus study in which we investigate in what syntactic position (preverbal or postverbal) such low-accessible subjects are typically found in Dutch natural language. We examine the effects of both discourse accessibility (definiteness) and inherent accessibility (animacy). Our results show that definiteness and animacy interact in determining subject position in Dutch. Non-referential (bare) subjects are less likely to occur in preverbal position than definite subjects, and this tendency is reinforced when the subject is inanimate. This suggests that these two properties that make the subject less accessible together can ‘gang up’ against the subject first preference. The results support a probabilistic multifactorial account of syntactic variation.

Abstract

Autoinflammatory disorders (AID) are a heterogeneous group of diseases, characterized by an unprovoked innate immune response, resulting in recurrent or ongoing systemic inflammation and fever1-3. Inflammasomes are protein complexes with an essential role in pyroptosis and the caspase-1-mediated activation of the proinflammatory cytokines IL-1β, IL-17 and IL-18.

Abstract

This paper presents an overview of spatial deictic structures in Kata Kolok, a sign language which is indigenous to a Balinese village community. Sociolinguistic surveys and lexicographic comparisons have indicated that Kata Kolok is unrelated to the signing varieties in other parts of Bali and should be considered a sign language isolate as such. Kata Kolok emerged five generations ago and has been in intimate contact with spoken Balinese from its incipience. The findings from this paper suggest that this cross-modal contact has led to an absolute construction of the signing space, which is radically different in comparison to spatial deixis in other sign languages. Furthermore, Kata Kolok does not seem to have a class of true toponyms, but rather deploys deictic proto-toponyms. The Kata Kolok system on the whole does not exhibit any related linguistic forms or direct calques from spoken Balinese, and this suggests that the conceptual overlap between these two languages may have been facilitated by shared cultural practices as well as gestural communication rather than direct borrowings. Ultimately, this analysis challenges the very notion of a sign language isolate and suggests that Kata Kolok and other emergent signing varieties should be considered in light of the broader semiotic context in which they have evolved.

Abstract

How do new languages develop systematic ways to talk about sensory experiences, such as color? To what extent is the evolution of color terms guided by societal factors? This paper describes the color lexicon of a rural sign language called Kata Kolok which emerged approximately one century ago in a Balinese village. Kata Kolok has four color signs: black, white, red and a blue-green term. In addition, two non-conventionalized means are used to provide color descriptions: naming relevant objects, and pointing to objects in the vicinity. Comparison with Balinese culture and spoken Balinese brings to light discrepancies between the systems, suggesting that neither cultural practices nor language contact have driven the formation of color signs in Kata Kolok. The few lexicographic investigations from other rural sign languages report limitations in the domain of color. On the other hand, larger, urban signed languages have extensive systems, for example, Australian Sign Language has up to nine color terms (Woodward 1989: 149). These comparisons support the finding that, rural sign languages like Kata Kolok fail to provide the societal pressures for the lexicon to expand further.

Abstract

Language acquisition in both natural and artificial language learning settings crucially depends on extracting information from sequence input. A shared sequence learning mechanism is thus assumed to underlie both natural and artificial language learning. A growing body of empirical evidence is consistent with this hypothesis. By means of artificial language learning experiments, we may therefore gain more insight in this shared mechanism. In this paper, we review empirical evidence from artificial language learning and computational modelling studies, as well as natural language data, and suggest that there are two key factors that help determine processing complexity in sequence learning, and thus in natural language processing. We propose that the specific ordering of non-adjacent dependencies (i.e., nested or crossed), as well as the number of non-adjacent dependencies to be resolved simultaneously (i.e., two or three) are important factors in gaining more insight into the boundaries of human sequence learning; and thus, also in natural language processing. The implications for theories of linguistic competence are discussed.

Abstract

Background Various CACNA1A missense mutations cause familial hemiplegic migraine type 1 (FHM1), a rare monogenic subtype of migraine with aura. FHM1 mutation R192Q is associated with pure hemiplegic migraine, whereas the S218L mutation causes hemiplegic migraine, cerebellar ataxia, seizures, and mild head trauma-induced brain edema. Transgenic knock-in (KI) migraine mouse models were generated that carried either the FHM1 R192Q or the S218L mutation and were shown to exhibit increased CaV2.1 channel activity. Here we investigated their cerebellar and caudal cortical transcriptome. Methods Caudal cortical and cerebellar RNA expression profiles from mutant and wild-type mice were studied using microarrays. Respective brain regions were selected based on their relevance to migraine aura and ataxia. Relevant expression changes were further investigated at RNA and protein level by quantitative polymerase chain reaction (qPCR) and/or immunohistochemistry, respectively. Results Expression differences in the cerebellum were most pronounced in S218L mice. Particularly, tyrosine hydroxylase, a marker of delayed cerebellar maturation, appeared strongly upregulated in S218L cerebella. In contrast, only minimal expression differences were observed in the caudal cortex of either mutant mice strain. Conclusion Despite pronounced consequences of migraine gene mutations at the neurobiological level, changes in cortical RNA expression in FHM1 migraine mice compared to wild-type are modest. In contrast, pronounced RNA expression changes are seen in the cerebellum of S218L mice and may explain their cerebellar ataxia phenotype

Abstract

The role of attentional control in lexical ambiguity resolution was examined in two patients with damage to the left inferior frontal gyrus (LIFG) and one control patient with non-LIFG damage. Experiment 1 confirmed that the LIFG patients had attentional control deficits compared to normal controls while the non-LIFG patient was relatively unimpaired. Experiment 2 showed that all three patients did as well as normal controls in using biasing sentence context to resolve lexical ambiguities involving balanced ambiguous words, but only the LIFG patients took an abnormally long time on lexical ambiguities that resolved toward a subordinate meaning of biased ambiguous words. Taken together, the results suggest that attentional control plays an important role in the resolution of certain lexical ambiguities – those that induce strong interference from context-inappropriate meanings (i.e., dominant meanings of biased ambiguous words).

Abstract

To highlight relevant information in dialogues, both wh-question context and pitch accent in answers can be used, such that focused information gains more attention and is processed more elaborately. To evaluate the relative influence of context and pitch accent on the depth of semantic processing, we measured Event-Related Potentials (ERPs) to auditorily presented wh-question-answer pairs. A semantically incongruent word in the answer occurred either in focus or non-focus position as determined by the context, and this word was either accented or unaccented. Semantic incongruency elicited different N400 effects in different conditions. The largest N400 effect was found when the question-marked focus was accented, while the other three conditions elicited smaller N400 effects. The results suggest that context and accentuation interact. Thus accented focused words were processed more deeply compared to conditions where focus and accentuation mismatched, or when the new information had no marking. In addition, there seems to be sex differences in the depth of semantic processing. For males, a significant N400 effect was observed only when the question-marked focus was accented, reduced N400 effects were found in the other dialogues. In contrast, females produced similar N400 effects in all the conditions. These results suggest that regardless of external cues, females tend to engage in more elaborate semantic processing compared to males.

Abstract

Genome-wide association study results have yielded evidence for the association of common genetic variants with crude measures of completed educational attainment in adults. Whilst informative, these results do not inform as to the mechanism of these effects or their presence at earlier ages and where educational performance is more routinely and more precisely assessed. Single nucleotide polymorphisms exhibiting genome-wide significant associations with adult educational attainment were combined to derive an unweighted allele score in 5,979 and 6,145 young participants from the Avon Longitudinal Study of Parents and Children with key stage 3 national curriculum test results (SATS results) available at age 13 to 14 years in English and mathematics respectively. Standardised (z-scored) results for English and mathematics showed an expected relationship with sex, with girls exhibiting an advantage over boys in English (0.433 SD (95%CI 0.395, 0.470), p<10-10) with more similar results (though in the opposite direction) in mathematics (0.042 SD (95%CI 0.004, 0.080), p = 0.030). Each additional adult educational attainment increasing allele was associated with 0.041 SD (95%CI 0.020, 0.063), p = 1.79×10-04 and 0.028 SD (95%CI 0.007, 0.050), p = 0.01 increases in standardised SATS score for English and mathematics respectively. Educational attainment is a complex multifactorial behavioural trait which has not had heritable contributions to it fully characterised. We were able to apply the results from a large study of adult educational attainment to a study of child exam performance marking events in the process of learning rather than realised adult end product. Our results support evidence for common, small genetic contributions to educational attainment, but also emphasise the likely lifecourse nature of this genetic effect. Results here also, by an alternative route, suggest that existing methods for child examination are able to recognise early life variation likely to be related to ultimate educational attainment.

Abstract

We report detailed analyses of a very large database on timing of speech perception collected by Smits et al. (Smits, R., Warner, N., McQueen, J.M., Cutler, A., 2003. Unfolding of phonetic information over time: A database of Dutch diphone perception. J. Acoust. Soc. Am. 113, 563–574). Eighteen listeners heard all possible diphones of Dutch, gated in portions of varying size and presented without background noise. The present report analyzes listeners’ responses across gates in terms of phonological features (voicing, place, and manner for consonants; height, backness, and length for vowels). The resulting patterns for feature perception differ from patterns reported when speech is presented in noise. The data are also analyzed for effects of stress and of phonological context (neighboring vowel vs. consonant); effects of these factors are observed to be surprisingly limited. Finally, statistical effects, such as overall phoneme frequency and transitional probabilities, along with response biases, are examined; these too exercise only limited effects on response patterns. The results suggest highly accurate speech perception on the basis of acoustic information alone.

Abstract

Korean has a very complex phonology, with many interacting alternations. In a coronal-/i/ sequence, depending on the type of phonological boundary present, alternations such as palatalization, nasal insertion, nasal assimilation, coda neutralization, and intervocalic voicing can apply. This paper investigates how the phonological patterns of Korean affect processing of morphemes and words. Past research on languages such as English, German, Dutch, and Finnish has shown that listeners exploit syllable structure constraints in processing speech and segmenting it into words. The current study shows that in parsing speech, listeners also use much more complex patterns that relate the surface phonological string to various boundaries.

Abstract

Background/Aims: Evidence from spoken word recognition suggests that for English listeners, distinguishing full versus reduced vowels is important, but discerning stress differences involving the same full vowel (as in mu- from music or museum) is not. In Dutch, in contrast, the latter distinction is important. This difference arises from the relative frequency of unstressed full vowels in the two vocabularies. The goal of this paper is to determine how this difference in the lexicon influences the perception of stressed versus unstressed vowels. Methods: All possible sequences of two segments (diphones) in Dutch and in English were presented to native listeners in gated fragments. We recorded identification performance over time throughout the speech signal. The data were here analysed specifically for patterns in perception of stressed versus unstressed vowels. Results: The data reveal significantly larger stress effects (whereby unstressed vowels are harder to identify than stressed vowels) in English than in Dutch. Both language-specific and shared patterns appear regarding which vowels show stress effects. Conclusion: We explain the larger stress effect in English as reflecting the processing demands caused by the difference in use of unstressed vowels in the lexicon. The larger stress effect in English is due to relative inexperience with processing unstressed full vowels

Abstract

Twenty American English listeners identified gated fragments of all 2288 possible English within-word and cross-word diphones, providing a total of 538 560 phoneme categorizations. The results show orderly uptake of acoustic information in the signal and provide a view of where information about segments occurs in time. Information locus depends on each speech sound’s identity and phonological features. Affricates and diphthongs have highly localized information so that listeners’ perceptual accuracy rises during a confined time range. Stops and sonorants have more distributed and gradually appearing information. The identity and phonological features (e.g., vowel vs consonant) of the neighboring segment also influences when acoustic information about a segment is available. Stressed vowels are perceived significantly more accurately than unstressed vowels, but this effect is greater for lax vowels than for tense vowels or diphthongs. The dataset charts the availability of perceptual cues to segment identity across time for the full phoneme repertoire of English in all attested phonetic contexts.

Abstract

An event-related brain potential experiment was carried out to investigate on-line syntactic processing in patients with Broca’s aphasia. Subjects were visually presented with sentences that were either syntactically correct or contained violations of word-category. Three groups of subjects were tested: Broca patients (N=11), non-aphasic patients with a right hemisphere (RH) lesion (N=9), and healthy aged-matched controls (N=15). Both control groups appeared sensitive to the violations of word-category as shown by clear P600/SPS effects. The Broca patients displayed only a very reduced and delayed P600/SPS effect. The results are discussed in the context of a lexicalist parsing model. It is concluded that Broca patients are hindered to detect on-line violations of word-category, if word class information is incomplete or delayed available.

Abstract

Two cross-modal priming studies investigated the recognition of English words spoken with a foreign accent. Auditory English primes were either typical of a Dutch accent or typical of a Japanese accent in English and were presented to both Dutch and Japanese L2 listeners. Lexical-decision times to subsequent visual target words revealed that foreign-accented words can facilitate word recognition for L2 listeners if at least one of two requirements is met: the foreign-accented production is in accordance with the language background of the L2 listener, or the foreign accent is perceptually confusable with the standard pronunciation for the L2 listener. If neither one of the requirements is met, no facilitatory effect of foreign accents on L2 word recognition is found. Taken together, these findings suggest that linguistic experience with a foreign accent affects the ability to recognize words carrying this accent, and there is furthermore a general benefit for L2 listeners for recognizing foreign-accented words that are perceptually confusable with the standard pronunciation.

Abstract

Two cross-modal priming experiments examined two questions about word recognition in foreign-accented speech: Does accent adaptation occur only for genuine accents markers, and does adaptation depend on language experience? We compared recognition of words spoken with canonical, genuinely-accented and arbitrarily-accented vowels. In Experiment 1, an Italian speaker pronounced vowels in English prime words canonically, or by lengthening /ɪ/ as in a genuine Italian accent (*/tri:k/ for trick), or by arbitrarily shortening /i:/ (*/trɪt/ for treat). Lexical-decision times to subsequent visual target words showed different priming effects in three listener groups. Monolingual native English listeners recognized variants with lengthened but not shortened vowels. Bilingual nonnative Italian-English listeners, who could not reliably distinguish vowel length, recognized both variants. Bilingual nonnative Dutch-English listeners also recognized both variants. In Experiment 2, bilingual Dutch-English listeners recognized Dutch words with genuinely- and arbitrarily-accented vowels (spoken by a native Italian with lengthened and shortened vowels respectively), but recognized words with canonical vowels more easily than words with accented vowels. These results suggest that adaptation to genuine accent markers arises for monolingual and bilingual listeners alike and can occur in native and nonnative languages, but that bilinguals can adapt to arbitrary accent markers better than monolinguals.

Abstract

This paper describes how reciprocity is expressed in the Papuan (i.e. non-Austronesian­) language Savosavo, spoken in the Solomon Islands. The main strategy is to use the reciprocal nominal mapamapa, which can occur in different NP positions and always triggers default third person singular masculine agreement, regardless of the number and gender of the referents. After a description of this as well as another strategy that is occasionally used (the ‘joint activity construction’), the paper will provide a detailed analysis of data elicited with set of video stimuli and show that the main strategy is used to describe even clearly asymmetric situations, as long as more than one person acts on more than one person in a joint activity.

Abstract

Humans differ widely in their navigational abilities. Studies have shown that self-reports on navigational abilities are good predictors of performance on navigation tasks in real and virtual environments. The caudate nucleus and medial temporal lobe regions have been suggested to subserve different navigational strategies. The ability to use different strategies might underlie navigational ability differences. This study examines the anatomical correlates of self-reported navigational ability in both gray and white matter. Local gray matter volume was compared between a group (N = 134) of good and bad navigators using voxel-based morphometry (VBM), as well as regional volumes. To compare between good and bad navigators, we also measured white matter anatomy using diffusion tensor imaging (DTI) and looked at fractional anisotropy (FA) values. We observed a trend toward higher local GM volume in right anterior parahippocampal/rhinal cortex for good versus bad navigators. Good male navigators showed significantly higher local GM volume in right hippocampus than bad male navigators. Conversely, bad navigators showed increased FA values in the internal capsule, the white matter bundle closest to the caudate nucleus and a trend toward higher local GM volume in the caudate nucleus. Furthermore, caudate nucleus regional volume correlated negatively with navigational ability. These convergent findings across imaging modalities are in line with findings showing that the caudate nucleus and the medial temporal lobes are involved in different wayfinding strategies. Our study is the first to show a link between self-reported large-scale navigational abilities and different measures of brain anatomy.

Abstract

The brain-derived neurotrophic factor (BDNF) was shown to be involved in spatial memory and spatial strategy preference. A naturally occurring single nucleotide polymorphism of the BDNF gene (Val66Met) affects activity-dependent secretion of BDNF. The current event-related fMRI study on preselected groups of ‘Met’ carriers and homozygotes of the ‘Val’ allele investigated the role of this polymorphism on encoding and retrieval in a virtual navigation task in 37 healthy volunteers. In each trial, participants navigated toward a target object. During encoding, three positional cues (columns) with directional cues (shadows) were available. During retrieval, the invisible target had to be replaced while either two objects without shadows (objects trial) or one object with a shadow (shadow trial) were available. The experiment consisted of blocks, informing participants of which trial type would be most likely to occur during retrieval. We observed no differences between genetic groups in task performance or time to complete the navigation tasks. The imaging results show that Met carriers compared to Val homozygotes activate the left hippocampus more during successful object location memory encoding. The observed effects were independent of non-significant performance differences or volumetric differences in the hippocampus. These results indicate that variations of the BDNF gene affect memory encoding during spatial navigation, suggesting that lower levels of BDNF in the hippocampus results in less efficient spatial memory processing

Abstract

Early language development is known to be under genetic influence, but the genes affecting normal variation in the general population remain largely elusive. Recent studies of disorder reported that variants of the CNTNAP2 gene are associated both with language deficits in specific language impairment (SLI) and with language delays in autism. We tested the hypothesis that these CNTNAP2 variants affect communicative behavior, measured at 2 years of age in a large epidemiological sample, the Western Australian Pregnancy Cohort (Raine) Study. Singlepoint analyses of 1149 children (606 males, 543 emales) revealed patterns of association which were strikingly reminiscent of those observed in previous investigations of impaired language, centered on the same genetic markers, and with a consistent direction of effect (rs2710102, p = .0239; rs759178, p = .0248). Based on these findings we performed analyses of four-marker haplotypes of rs2710102- s759178-rs17236239-rs2538976, and identified significant association (haplotype TTAA, p = .049; haplotype GCAG, p = .0014). Our study suggests that common variants in the exon 13-15 region of CNTNAP2 influence early language acquisition, as assessed at age 2, in the general population. We propose that these CNTNAP2 variants increase susceptibility to SLI or autism when they occur together with other risk factors.

Abstract

Studies on metacognition have shown that participants can report on their performance on a wide range of perceptual, memory and behavioral tasks. We know little, however, about the ability to report on one's attentional focus. The degree and direction of somatosensory attention can, however, be readily discerned through suppression of alpha band frequencies in EEG/MEG produced by the somatosensory cortex. Such top-down attentional modulations of cortical excitability have been shown to result in better discrimination performance and decreased response times. In this study we asked whether the degree of attentional focus is also accessible for subjective report, and whether such evaluations correspond to the amount of somatosensory alpha activity. In response to auditory cues participants maintained somatosensory attention to either their left or right hand for intervals varying randomly between 5 and 32seconds, while their brain activity was recorded with MEG. Trials were terminated by a probe sound, to which they reported their level of attention on the cued hand right before probe-onset. Using a beamformer approach, we quantified the alpha activity in left and right somatosensory regions, one second before the probe. Alpha activity from contra- and ipsilateral somatosensory cortices for high versus low attention trials were compared. As predicted, the contralateral somatosensory alpha depression correlated with higher reported attentional focus. Finally, alpha activity two to three seconds before the probe-onset was correlated with attentional focus. We conclude that somatosensory attention is indeed accessible to metacognitive awareness.

Abstract

Phonological knowledge of a language involves knowledge about which segments can be combined under what conditions. Languages vary in the quantity and quality of licensed combinations, in particular sequences of consonants, with Polish being a language with a large inventory of such combinations. The present paper reports on a two-session experiment in which Polish-speaking adult participants learned nonce words with final consonant clusters. The aim was to study the role of two factors which potentially play a role in the learning of phonotactic structures: the phonological principle of sonority (ordering sound segments within the syllable according to their inherent loudness) and the (non-) existence as a usage-based phenomenon. EEG responses in two different time windows (adversely to behavioral responses) show linguistic processing by native speakers of Polish to be sensitive to both distinctions, in spite of the fact that Polish is rich in sonority-violating clusters. In particular, a general learning effect in terms of an N400 effect was found which was demonstrated to be different for sonority-obeying clusters than for sonority-violating clusters. Furthermore, significant interactions of formedness and session, and of existence and session, demonstrate that both factors, the sonority principle and the frequency pattern, play a role in the learning process.

Abstract

Common ground is an essential prerequisite for coordination in social interaction, including language use. When referring back to a referent in discourse, this referent is ‘given information’ and therefore in the interactants’ common ground. When a referent is being referred to for the first time, a speaker introduces ‘new information’. The analyses reported here are on gestures that accompany such references when they include definite and indefinite grammatical determiners. The main finding from these analyses is that referents referred to by definite and indefinite articles were equally often accompanied by gesture, but speakers tended to accompany definite references with gestures focusing on action information and indefinite references with gestures focusing on entity information. The findings suggest that speakers use speech and gesture together to design utterances appropriate for speakers with whom they share common ground.

Abstract

Does language comprehension depend, in part, on neural systems for action? In previous studies, motor areas of the brain were activated when people read or listened to action verbs, but it remains unclear whether such activation is functionally relevant for comprehension. In the experiments reported here, we used off-line theta-burst transcranial magnetic stimulation to investigate whether a causal relationship exists between activity in premotor cortex and action-language understanding. Right-handed participants completed a lexical decision task, in which they read verbs describing manual actions typically performed with the dominant hand (e.g., “to throw,” “to write”) and verbs describing nonmanual actions (e.g., “to earn,” “to wander”). Responses to manual-action verbs (but not to nonmanual-action verbs) were faster after stimulation of the hand area in left premotor cortex than after stimulation of the hand area in right premotor cortex. These results suggest that premotor cortex has a functional role in action-language understanding.

Abstract

We investigated how visual and linguistic information interact in the perception of emotion. We borrowed a phenomenon from film theory which states that presentation of an as such neutral visual scene intensifies the percept of fear or suspense induced by a different channel of information, such as language. Our main aim was to investigate how neutral visual scenes can enhance responses to fearful language content in parts of the brain involved in the perception of emotion. Healthy participants’ brain activity was measured (using functional magnetic resonance imaging) while they read fearful and less fearful sentences presented with or without a neutral visual scene. The main idea is that the visual scenes intensify the fearful content of the language by subtly implying and concretizing what is described in the sentence. Activation levels in the right anterior temporal pole were selectively increased when a neutral visual scene was paired with a fearful sentence, compared to reading the sentence alone, as well as to reading of non-fearful sentences presented with the same neutral scene. We conclude that the right anterior temporal pole serves a binding function of emotional information across domains such as visual and linguistic information.

Abstract

A debated issue in the relationship between language and thought is how our linguistic abilities are involved in understanding the intentions of others (‘mentalizing’). The results of both theoretical and empirical work have been used to argue that linguistic, and more specifically, grammatical, abilities are crucial in representing the mental states of others. Here we contribute to this debate by investigating how damage to the language system influences the generation and understanding of intentional communicative behaviors. Four patients with pervasive language difficulties (severe global or agrammatic aphasia) engaged in an experimentally controlled non-verbal communication paradigm, which required signaling and understanding a communicative message. Despite their profound language problems they were able to engage in recipient design as well as intention recognition, showing similar indicators of mentalizing as have been observed in the neurologically healthy population. Our results show that aspects of the ability to communicate remain present even when core capacities of the language system are dysfunctional

Abstract

Do people use sensori-motor cortices to understand language? Here we review neurocognitive studies of language comprehension in healthy adults and evaluate their possible contributions to theories of language in the brain. We start by sketching the minimal predictions that an embodied theory of language understanding makes for empirical research, and then survey studies that have been offered as evidence for embodied semantic representations. We explore four debated issues: first, does activation of sensori-motor cortices during action language understanding imply that action semantics relies on mirror neurons? Second, what is the evidence that activity in sensori-motor cortices plays a functional role in understanding language? Third, to what extent do responses in perceptual and motor areas depend on the linguistic and extra-linguistic context? And finally, can embodied theories accommodate language about abstract concepts? Based on the available evidence, we conclude that sensori-motor cortices are activated during a variety of language comprehension tasks, for both concrete and abstract language. Yet, this activity depends on the context in which perception and action words are encountered. Although modality-specific cortical activity is not a sine qua non of language processing even for language about perception and action, sensori-motor regions of the brain appear to make functional contributions to the construction of meaning, and should therefore be incorporated into models of the neurocognitive architecture of language.

Abstract

Left-handers are often excluded from study cohorts in neuroscience and neurogenetics in order to reduce variance in the data. However, recent investigations have shown that the inclusion or targeted recruitment of left-handers can be informative in studies on a range of topics, such as cerebral lateralization and the genetic underpinning of asymmetrical brain development. Left-handed individuals represent a substantial portion of the human population and therefore left-handedness falls within the normal range of human diversity; thus, it is important to account for this variation in our understanding of brain functioning. We call for neuroscientists and neurogeneticists to recognize the potential of studying this often-discarded group of research subjects.

Abstract

Marr and Poggio’s levels of description are one of the most well-known theoretical constructs of twentieth century cognitive science. It entails that behavior can and should be considered at three different levels: computation, algorithm, and implementation. In this contribution focus is on the computational level of description, the level that describes the “why” of cognition. I argue that the computational level should be taken as a starting point in devising experiments in cognitive (neuro)science. Instead, the starting point in empirical practice often is a focus on the stimulus or on some capacity of the cognitive system. The “why” of cognition tends to be ignored when designing research, and is not considered in subsequent inference from experimental results. The overall aim of this manuscript is to show how re-appreciation of the computational level of description as a starting point for experiments can lead to more informative experimentation.

Abstract

While most people prefer to use their right hand to brush their teeth, throw a ball, or hold a tennis racket, left-handers prefer to use their left hand. This is the case for around 10 per cent of all people. There was a time (not so long ago) when left-handers were stigmatized in Western (and other) communities: it was considered a bad sign if you were left-handed, and left-handed children were often forced to write with their right hand. This is nonsensical: there is nothing wrong with being left-handed, and trying to write with the non-preferred hand is frustrating for almost everybody. As a matter of fact, science can learn from left-handers, and in this paper, we discuss how this may be the case. We review why some people are left-handed and others are not, how left-handers' brains differ from right-handers’, and why scientists study left-handedness in the first place

Abstract

Are listeners able to adapt to a foreign-accented speaker who has, as is often the case, an inconsistent accent? Two groups of native Dutch listeners participated in a cross-modal priming experiment, either in a consistent-accent condition (German-accented items only) or in an inconsistent-accent condition (German-accented and nativelike pronunciations intermixed). The experimental words were identical for both groups (words with vowel substitutions characteristic of German-accented speech); additional contextual words differed in accentedness (German-accented or nativelike words). All items were spoken by the same speaker: a German native who could produce the accented forms but could also pass for a Dutch native speaker. Listeners in the consistent-accent group were able to adapt quickly to the speaker (i.e., showed facilitatory priming for words with vocalic substitutions). Listeners in the inconsistent-accent condition showed adaptation to words with vocalic substitutions only in the second half of the experiment. These results indicate that adaptation to foreign-accented speech is rapid. Accent inconsistency slows listeners down initially, but a short period of additional exposure is enough for them to adapt to the speaker. Listeners can therefore tolerate inconsistency in foreign-accented speech.

Abstract

It is often assumed odors are associated with hot and cold temperature, since odor processing may trigger thermal sensations, such as coolness in the case of mint. It is unknown, however, whether people make consistent temperature associations for a variety of everyday odors, and, if so, what determines them. Previous work investigating the bases of cross-modal associations suggests a number of possibilities, including universal forces (e.g., perception), as well as culture-specific forces (e.g., language and cultural beliefs). In this study, we examined odor-temperature associations in three cultures—Maniq (N = 11), Thai (N = 24), and Dutch (N = 24)—who differ with respect to their cultural preoccupation with odors, their odor lexicons, and their beliefs about the relationship of odors (and odor objects) to temperature. Participants matched 15 odors to temperature by touching cups filled with hot or cold water, and described the odors in their native language. The results showed no consistent associations among the Maniq, and only a handful of consistent associations between odor and temperature among the Thai and Dutch. The consistent associations differed across the two groups, arguing against their universality. Further analysis revealed cross-modal associations could not be explained by language, but could be the result of cultural beliefs

Abstract

It is widely believed that human languages cannot encode odors. While this is true for English,
and other related languages, data from some non-Western languages challenge this
view. Maniq, a language spoken by a small population of nomadic hunter–gatherers in
southern Thailand, is such a language. It has a lexicon of over a dozen terms dedicated
to smell. We examined the semantics of these smell terms in 3 experiments (exemplar
listing, similarity judgment and off-line rating). The exemplar listing task confirmed that
Maniq smell terms have complex meanings encoding smell qualities. Analyses of the
similarity data revealed that the odor lexicon is coherently structured by two dimensions.
The underlying dimensions are pleasantness and dangerousness, as verified by the off-line
rating study. Ethnographic data illustrate that smell terms have detailed semantics tapping
into broader cultural constructs. Contrary to the widespread view that languages cannot
encode odors, the Maniq data show odor can be a coherent semantic domain, thus shedding
new light on the limits of language.

Abstract

The cerebellar ataxias are a group of incurable brain disorders that are caused primarily by the progressive dysfunction and degeneration of cerebellar Purkinje cells. The lack of reliable disease models for the heterogeneous ataxias has hindered the understanding of the underlying pathogenic mechanisms as well as the development of effective therapies for these devastating diseases. Recent advances in the field of induced pluripotent stem cell (iPSC) technology offer new possibilities to better understand and potentially reverse disease pathology. Given the neurodevelopmental phenotypes observed in several types of ataxias, iPSC-based models have the potential to provide significant insights into disease progression, as well as opportunities for the development of early intervention therapies. To date, however, very few studies have successfully used iPSC-derived cells to cerebellar ataxias. In this review, we focus on recent breakthroughs in generating human iPSC-derived Purkinje cells. We also highlight the future challenges that will need to be addressed in order to fully exploit these models for the modelling of the molecular mechanisms underlying cerebellar ataxias and the development of effective therapeutics.

Abstract

Jedek is a previously unrecognized variety of the Northern Aslian subgroup of the Aslian branch of the Austroasiatic language family. It is spoken by c. 280 individuals in the resettlement area of Sungai Rual, near Jeli in Kelantan state, Peninsular Malaysia. The community originally consisted of several bands of foragers along the middle reaches of the Pergau river. Jedek’s distinct status first became known during a linguistic survey carried out in the DOBES project Tongues of the Semang (2005-2011). This paper describes the process leading up to its discovery and provides an overview of its typological characteristics.

Abstract

Neural structures change with age but there is no consensus on the exact processes involved. This study tested the hypothesis that white and grey matter in the language network changes during aging according to a “last in, first out” process. The fractional anisotropy (FA) of white matter and cortical thickness of grey matter were measured in 36 participants whose ages ranged from 55 to 79 years. Within the language network, the dorsal pathway connecting the mid-to-posterior superior temporal cortex (STC) and the inferior frontal cortex (IFC) was affected more by aging in both FA and thickness than the other dorsal pathway connecting the STC with the premotor cortex and the ventral pathway connecting the mid-to-anterior STC with the ventral IFC. These results were independently validated in a second group of 20 participants whose ages ranged from 50 to 73 years. The pathway that is most affected during aging matures later than the other two pathways (which are present at birth). The results are interpreted as showing that the neural structures which mature later are affected more than those that mature earlier, supporting the “last in, first out” theory.

Abstract

Using the masked priming paradigm, we examined which phonological unit is used when naming Kanji compounds. Although the phonological unit in the Japanese language has been suggested to be the mora, Experiment 1 found no priming for mora-related Kanji prime-target pairs. In Experiment 2, significant priming was only found when Kanji pairs shared the whole sound of their initial Kanji characters. Nevertheless, when the same Kanji pairs used in Experiment 2 were transcribed into Kana, significant mora priming was observed in Experiment 3. In Experiment 4, matching the syllable structure and pitch-accent of the initial Kanji characters did not lead to mora priming, ruling out potential alternative explanations for the earlier absence of the effect. A significant mora priming effect was observed, however, when the shared initial mora constituted the whole sound of their initial Kanji characters in Experiments 5. Lastly, these results were replicated in Experiment 6. Overall, these results indicate that the phonological unit involved when naming Kanji compounds is not the mora but the whole sound of each Kanji character. We discuss how different phonological units may be involved when processing Kanji and Kana words as well as the implications for theories dealing with language production processes.

Abstract

This article reports on several sub-projects of research and development related to the use of Indian Sign Language in educational settings. In many countries around the world, sign languages are now recognised as the legitimate, full-fledged languages of the deaf communities that use them. In India, the development of sign language resources and their application in educational contexts, is still in its initial stages. The work reported on here, is the first principled and comprehensive effort of establishing educational programmes in Indian Sign Language at a national level. Programmes are of several types: a) Indian Sign Language instruction for hearing people; b) sign language teacher training programmes for deaf people; and c) educational materials for use in schools for the Deaf. The conceptual approach used in the programmes for deaf students is known as bilingual education, which emphasises the acquisition of a first language, Indian Sign Language, alongside the acquisition of spoken languages, primarily in their written form.

Abstract

Indo-Pakistani Sign Language (IPSL) is the sign language used by deaf communities in a large region across India and Pakistan. This visual-gestural language has a dedicated construction for specifically expressing reciprocal relationships, which can be applied to agreement verbs and to auxiliaries. The reciprocal construction relies on a change in the movement pattern of the signs it applies to. In addition, IPSL has a number of other strategies which can have a reciprocal interpretation, and the IPSL lexicon includes a good number of inherently reciprocal signs. All reciprocal expressions can be modified in complex ways that rely on the grammatical use of the sign space. Considering grammaticalisation and lexicalisation processes linking some of these constructions is also important for a better understanding of reciprocity in IPSL.

Abstract

In response to DNA damage or replication stress, the protein kinase ATR is activated and subsequently transduces genotoxic signals to cell cycle control and DNA repair machinery through phosphorylation of a number of downstream substrates. Very little is known about the molecular mechanism by which ATR is activated in response to genotoxic insults. In this report, we demonstrate that protein phosphatase 5 (PP5) is required for the ATR-mediated checkpoint activation. PP5 forms a complex with ATR in a genotoxic stress-inducible manner. Interference with the expression or the activity of PP5 leads to impairment of the ATR-mediated phosphorylation of hRad17 and Chk1 after UV or hydroxyurea treatment. Similar results are obtained in ATM-deficient cells, suggesting that the observed defect in checkpoint signaling is the consequence of impaired functional interaction between ATR and PP5. In cells exposed to UV irradiation, PP5 is required to elicit an appropriate S-phase checkpoint response. In addition, loss of PP5 leads to premature mitosis after hydroxyurea treatment. Interestingly, reduced PP5 activity exerts differential effects on the formation of intranuclear foci by ATR and replication protein A, implicating a functional role for PP5 in a specific stage of the checkpoint signaling pathway. Taken together, our results suggest that PP5 plays a critical role in the ATR-mediated checkpoint activation.

Abstract

Scene-selective regions (SSRs), including the parahippocampal place area (PPA), retrosplenial cortex (RSC), and transverse occipital sulcus (TOS), are among the most widely characterized functional regions in the human brain. However, previous studies have mostly focused on the commonality within each SSR, providing little information on different aspects of their variability. In a large group of healthy adults (N = 202), we used functional magnetic resonance imaging to investigate different aspects of topographical and functional variability within SSRs, including interindividual, interhemispheric, and sex differences. First, the PPA, RSC, and TOS were delineated manually for each individual. We then demonstrated that SSRs showed substantial interindividual variability in both spatial topography and functional selectivity. We further identified consistent interhemispheric differences in the spatial topography of all three SSRs, but distinct interhemispheric differences in scene selectivity. Moreover, we found that all three SSRs showed stronger scene selectivity in men than in women. In summary, our work thoroughly characterized the interindividual, interhemispheric, and sex variability of the SSRs and invites future work on the origin and functional significance of these variabilities. Additionally, we constructed the first probabilistic atlases for the SSRs, which provide the detailed anatomical reference for further investigations of the scene network.

Abstract

For most people, speech production is relatively effortless and error-free. Yet it has long been recognized that we need some type of control over what we are currently saying and what we plan to say. Precisely how we monitor our internal and external speech has been a topic of research interest for several decades. The predominant approach in psycholinguistics has assumed monitoring of both is accomplished via systems responsible for comprehending others' speech.

This special topic aimed to broaden the field, firstly by examining proposals that speech production might also engage more general systems, such as those involved in action monitoring. A second aim was to examine proposals for a production-specific, internal monitor. Both aims require that we also specify the nature of the representations subject to monitoring.

Abstract

Given the limited processing capabilities of the sensory system, it is essential that attended information is gated to downstream areas, whereas unattended information is blocked. While it has been proposed that alpha band (8–13 Hz) activity serves to route information to downstream regions by inhibiting neuronal processing in task-irrelevant regions, this hypothesis remains untested. Here we investigate how neuronal oscillations detected by electroencephalography in visual areas during working memory encoding serve to gate information reflected in the simultaneously recorded blood-oxygenation-level-dependent (BOLD) signals recorded by functional magnetic resonance imaging in downstream ventral regions. We used a paradigm in which 16 participants were presented with faces and landscapes in the right and left hemifields; one hemifield was attended and the other unattended. We observed that decreased alpha power contralateral to the attended object predicted the BOLD signal representing the attended object in ventral object-selective regions. Furthermore, increased alpha power ipsilateral to the attended object predicted a decrease in the BOLD signal representing the unattended object. We also found that the BOLD signal in the dorsal attention network inversely correlated with visual alpha power. This is the first demonstration, to our knowledge, that oscillations in the alpha band are implicated in the gating of information from the visual cortex to the ventral stream, as reflected in the representationally specific BOLD signal. This link of sensory alpha to downstream activity provides a neurophysiological substrate for the mechanism of selective attention during stimulus processing, which not only boosts the attended information but also suppresses distraction. Although previous studies have shown a relation between the BOLD signal from the dorsal attention network and the alpha band at rest, we demonstrate such a relation during a visuospatial task, indicating that the dorsal attention network exercises top-down control of visual alpha activity.

Abstract

Review: User friendliness of the first dictionary of Sign Language of the Netherlands can be improved

Abstract

(Needed: staff for residential care home with good eye-hand coordination. Measuring NGT-skills.)

Abstract

(The Corpus NGT and the daily practice of language teaching)

Abstract

(The Corpus NGT and teacher NGT/interpreter NGT training)