Publications

Abstract

The Logic of Language opens a new perspective on logic. Pieter Seuren argues that the logic of language derives from the lexical meanings of the logical operators. These meanings, however, prove not to be consistent. Seuren solves this problem through an indepth analysis of the functional adequacy of natural predicate logic and standard modern logic for natural linguistic interaction. He then develops a general theory of discourse-bound interpretation, covering discourse incrementation, anaphora, presupposition and topic-comment structure, all of which, the author claims, form the 'cement' of discourse structure. This is the second of a two-volume foundational study of language, published under the title Language from Within . Pieter Seuren discusses such apparently diverse issues as the ontology underlying the semantics of language, speech act theory, intensionality phenomena, the machinery and ecology of language, sentential and lexical meaning, the natural logic of language and cognition, and the intrinsically context-sensitive nature of language - and shows them to be intimately linked. Throughout his ambitious enterprise, he maintains a constant dialogue with established views, reflecting their development from Ancient Greece to the present. The resulting synthesis concerns central aspects of research and theory in linguistics, philosophy and cognitive science.

Abstract

This study is a prolegomenon to a formal theory of the natural growth of conceptual and lexical fields. Negation, in the various forms in which it occurs in language, is found to be a powerful indicator. Other than in standard logic, natural language negation selects its complement within universes of discourse that are, for practical and functional reasons, restricted in various ways and to different degrees. It is hypothesized that a system of cognitive principles drives recursive processes of universe restriction, which in turn affects logical relations within the restricted universes. This approach provides a new perspective in which to view the well-known clashes between standard logic and natural logical intuitions. Lexicalization in language, especially the morphological incorporation of negation, is limited to highly restricted universes, which explains, for example, why a dog can be said not to be a Catholic, but also not to be a non-Catholic. Cognition is taken to restrict the universe of discourse to contrary pairs, splitting up one or both of the contraries into further subuniverses as a result of further cognitive activity. It is shown how a logically sound square of opposition , expanded to a hexagon (Jacoby 1950, 1960, Sesmat 1951, Blanché 1952, 1953, 1966), is generated by a hierarchy of universe restrictions, defining the notion ‘natural’ for logical systems. The logical hexagon contains two additional vertices, one for ‘some but not all’ (the Y-type) and one for ‘either all or none’ (the U-type), and incorporates both the classic square and the Hamiltonian triangle of contraries . Some is thus considered semantically ambiguous, representing two distinct quantifiers. The pragmaticist claim that the language system contains only the standard logical ‘some perhaps all’ and that the ‘some but not all’ meaning is pragmatically derived from the use of the system is rejected. Four principles are proposed according to which negation selects a complement from the subuniverses at hand. On the basis of these principles and of the logico-cognitive system proposed, the well-known nonlexicalization not only of *nall and *nand but also of many other nonlogical cases found throughout the lexicons of languages is analyzed and explained

Abstract

Since Aristotle and the Stoa, there has been a clash, worsened by modern predicate logic, between logically defined operator meanings and natural intuitions. Pragmatics has tried to neutralize the clash by an appeal to the Gricean conversational maxims. The present study argues that the pragmatic attempt has been unsuccessful. The “softness” of the Gricean explanation fails to do justice to the robustness of the intuitions concerned, leaving the relation between the principles evoked and the observed facts opaque. Moreover, there are cases where the Gricean maxims fail to apply. A more adequate solution consists in the devising of a sound natural logic, part of the innate cognitive equipment of mankind. This account has proved successful in conjunction with a postulated cognitive mechanism in virtue of which the universe of discourse (Un) is stepwise and recursively restricted, so that the negation selects different complements according to the degree of restrictedness of Un. This mechanism explains not only the discrepancies between natural logical intuitions and known logical systems; it also accounts for certain systematic lexicalization gaps in the languages of the world. Finally, it is shown how stepwise restriction of Un produces the ontogenesis of natural predicate logic, while at the same time resolving the intuitive clashes with established logical systems that the Gricean maxims sought to explain

Abstract

In this study it is argued that scope, as a property of scope‐creating operators, is a real and important element in the semantico‐grammatical description of languages. The notion of scope is illustrated and, as far as possible, defined. A first idea is given of the ‘grammar of scope’, which defines the relation between scope in the logically structured semantic analysis (SA) of sentences on the one hand and surface structure on the other. Evidence is adduced showing that peripheral preposition phrases (PPPs) in the surface structure of sentences represent scope‐creating operators in SA, and that external datives fall into this category: they are scope‐creating PPPs. It follows that, in English and Dutch, the internal dative (I gave John a book) and the external dative (I gave a book to John) are not simple syntactic variants expressing the same meaning. Instead, internal datives are an integral part of the argument structure of the matrix predicate, whereas external datives represent scope‐creating operators in SA. In the Romance languages, the (non‐pronominal) external dative has been re‐analysed as an argument type dative, but this has not happened in English and Dutch, which have many verbs that only allow for an external dative (e.g. donate, reveal). When both datives are allowed, there are systematic semantic differences, including scope differences.

Abstract

Notch signaling in the nervous system is often regarded as a developmental pathway. However, recent studies have suggested that Notch is associated with neuronal discharges. Here, focusing on temporal lobe epilepsy, we found that Notch signaling was activated in the kainic acid (KA)-induced epilepsy model and in human epileptogenic tissues. Using an acute model of seizures, we showed that DAPT, an inhibitor of Notch, inhibited ictal activity. In contrast, pretreatment with exogenous Jagged1 to elevate Notch signaling before KA application had proconvulsant effects. In vivo, we demonstrated that the impacts of activated Notch signaling on seizures can in part be attributed to the regulatory role of Notch signaling on excitatory synaptic activity in CA1 pyramidal neurons. In vitro, we found that DAPT treatment impaired synaptic vesicle endocytosis in cultured hippocampal neurons. Taken together, our findings suggest a correlation between aberrant Notch signaling and epileptic seizures. Notch signaling is up-regulated in response to seizure activity, and its activation further promotes neuronal excitation of CA1 pyramidal neurons in acute seizures.

Abstract

We investigated the neural basis of inhibitory control during lexical selection. Participants overtly named pictures while response times (RTs) and event-related brain potentials (ERPs) were recorded. The difficulty of lexical selection was manipulated by using object and action pictures with high name agreement (few response candidates) versus low name agreement (many response candidates). To assess the involvement of inhibition, we conducted delta plot analyses of naming RTs and examined the N2 component of the ERP. We found longer mean naming RTs and a larger N2 amplitude in the low relative to the high name agreement condition. For action naming we found a negative correlation between the slopes of the slowest delta segment and the difference in N2 amplitude between the low and high name agreement conditions. The converging behavioral and electrophysiological evidence suggests that selective inhibition is engaged to reduce competition during lexical selection in picture naming.

Abstract

The present study provides Dutch norms for age of acquisition, familiarity, imageability, image agreement, visual complexity, word frequency, and word length (in syllables) for 124 line drawings of actions. Ratings were obtained from 117 Dutch participants. Word frequency was determined on the basis of the SUBTLEX-NL corpus (Keuleers, Brysbaert, & New, Behavior Research Methods, 42, 643–650, 2010). For 104 of the pictures, naming latencies and name agreement were determined in a separate naming experiment with 74 native speakers of Dutch. The Dutch norms closely corresponded to the norms for British English. Multiple regression analysis showed that age of acquisition, imageability, image agreement, visual complexity, and name agreement were significant predictors of naming latencies, whereas word frequency and word length were not. Combined with the results of a principal-component analysis, these findings suggest that variables influencing the processes of conceptual preparation and lexical selection affect latencies more strongly than do variables influencing word-form encoding.

Abstract

This study examined the contributions of verbal ability and executive control to verbal fluency performance in older adults (n=82). Verbal fluency was assessed in letter and category fluency tasks, and performance on these tasks was related to indicators of vocabulary size, lexical access speed, updating, and inhibition ability. In regression analyses the number of words produced in both fluency tasks was predicted by updating ability, and the speed of the first response was predicted by vocabulary size and, for category fluency only, lexical access speed. These results highlight the hybrid character of both fluency tasks, which may limit their usefulness for research and clinical purposes.

Abstract

A corpus of digitized speech errors is used to compare the prosody of correction patterns for word-level vs. sound-level errors. Results for both peak F0 and perceived prosodic markedness confirm that speakers are more likely to mark corrections of word-level errors than corrections of sound-level errors, and that errors ambiguous between word-level and soundlevel (such as boat for moat) show correction patterns like those for sound level errors. This finding increases the plausibility of the claim that word-sound-ambiguous errors arise at the same level of processing as sound errors that do not form words.

Abstract

The results of an eye-tracking experiment are presented in which Dutch listeners' eye movements were monitored as they heard sentences and saw four pictured objects. Participants were instructed to click on the object mentioned in the sentence. In the critical sentences, a stop-initial target (e.g., "pot") was preceded by an [s], thus causing ambiguity regarding whether the sentence refers to a stop-initial or a cluster-initial word (e.g., "spot"). Participants made fewer fixations to the target pictures when the stop and the preceding [s] were cross-spliced from the cluster-initial word than when they were spliced from a different token of the sentence containing the stop-initial word. Acoustic analyses showed that the two versions differed in various measures, but only one of these - the duration of the [s] - correlated with the perceptual effect. Thus, in this context, the [s] duration information is an important factor guiding word recognition.

Abstract

Models of speech production disagree on whether or not homonyms have a shared word-form representation. To investigate this issue, a picture-naming experiment was carried out using Dutch homonyms of which both meanings could be presented as a picture. Naming latencies for the low-frequency meanings of homonyms were slower than for those of the high-frequency meanings. However, no frequency effect was found for control words, which matched the frequency of the homonyms meanings. Subsequent control experiments indicated that the difference in naming latencies for the homonyms could be attributed to processes earlier than wordform retrieval. Specifically, it appears that low name agreement slowed down the naming of the low-frequency homonym pictures.

Abstract

Pitch is often described metaphorically: for example, Farsi and Turkish speakers use a ‘thickness’ metaphor (low sounds are ‘thick’ and high sounds are ‘thin’), while German and English speakers use a height metaphor (‘low’, ‘high’). This study examines how child and adult speakers of Farsi, Turkish, and German map pitch and thickness using a cross-modal association task. All groups, except for German children, performed significantly better than chance. German-speaking adults’ success suggests the pitch-to-thickness association can be learned by experience. But the fact that German children were at chance indicates that this learning takes time. Intriguingly, Farsi and Turkish children's performance suggests that learning cross-modal associations can be boosted through experience with consistent metaphorical mappings in the input language

Abstract

Three experiments examined whether infants recognise functors in phrases, and whether their representations of functors are phonetically well specified. Eight- and 13- month-old English infants heard monosyllabic lexical words preceded by real functors (e.g., the, his) versus nonsense functors (e.g., kuh); the latter were minimally modified segmentally (but not prosodically) from real functors. Lexical words were constant across conditions; thus recognition of functors would appear as longer listening time to sequences with real functors. Eightmonth- olds' listening times to sequences with real versus nonsense functors did not significantly differ, suggesting that they did not recognise real functors, or functor representations lacked phonetic specification. However, 13-month-olds listened significantly longer to sequences with real functors. Thus, somewhere between 8 and 13 months of age infants learn familiar functors and represent them with segmental detail. We propose that accumulated frequency of functors in input in general passes a critical threshold during this time.

Abstract

Size analysis can be an important part of heap consumption analysis. This paper is a part of ongoing work about typing support for checking output-on-input size dependencies for function definitions in a strict functional language. A significant restriction for our earlier results is that inner data structures (e.g. in a list of lists) all must have the same size. Here, we make a big step forwards by overcoming this limitation via the introduction of higher-order size annotations such that variate sizes of inner data structures can be expressed. In this way the analysis becomes applicable for general, polymorphic nested lists.

Abstract

Contrary to linear difference equations, there is no general theory of difference equations of the form G(P(x−τ1),…,P(x−τs))+G0(x)=0, with τi∈K, G(x1,…,xs)∈K[x1,…,xs] of total degree D⩾2 and G0(x)∈K[x], where K is a field of characteristic zero. This article is concerned with the following problem: given τi, G and G0, find an upper bound on the degree d of a polynomial solution P(x), if it exists. In the presented approach the problem is reduced to constructing a univariate polynomial for which d is a root. The authors formulate a sufficient condition under which such a polynomial exists. Using this condition, they give an effective bound on d, for instance, for all difference equations of the form G(P(x−a),P(x−a−1),P(x−a−2))+G0(x)=0 with quadratic G, and all difference equations of the form G(P(x),P(x−τ))+G0(x)=0 with G having an arbitrary degree.

Abstract

Although an increasing number of sociolinguistic researchers consider functions of voice qualities as stylistic features, few studies consider cases where voice qualities serve as the primary signs of speech registers. This article addresses this gap through the presentation of a case study of Lachixio Zapotec speech registers indexed though falsetto, breathy, creaky, modal, and whispered voice qualities. I describe the system of contrastive speech registers in Lachixio Zapotec and then track a speaker on a single evening where she switches between three of these registers. Analyzing line-by-line conversational structure I show both obligatory and creative shifts between registers that co-occur with shifts in the participant structures of the situated social interactions. I then examine similar uses of voice qualities in other Zapotec languages and in the two unrelated language families Nahuatl and Mayan to suggest the possibility that such voice registers are a feature of the Mesoamerican culture area.

Abstract

Spontal-N is a corpus of spontaneous, interactional Norwegian. To our knowledge, it is the first corpus of Norwegian in which the majority of speakers have spent significant parts of their lives in Sweden, and in which the recorded speech displays varying degrees of interference from Swedish. The corpus consists of studio quality audio- and video-recordings of four 30-minute free conversations between acquaintances, and a manual orthographic transcription of the entire material. On basis of the orthographic transcriptions, we automatically annotated approximately 50 percent of the material on the phoneme level, by means of a forced alignment between the acoustic signal and pronunciations listed in a dictionary. Approximately seven percent of the automatic transcription was manually corrected. Taking the manual correction as a gold standard, we evaluated several sources of pronunciation variants for the automatic transcription. Spontal-N is intended as a general purpose speech resource that is also suitable for investigating phonetic detail.

Abstract

We investigated global integration (wrap-up) processes at the boundaries of musical phrases by comparing the effects of well and non-well formed phrases on event-related potentials time-locked to two boundary points: the onset and the offset of the boundary pause. The Closure Positive Shift, which is elicited at the boundary offset, was not modulated by the quality of phrase structure (well vs. non-well formed). In contrast, the boundary onset potentials showed different patterns for well and non-well formed phrases. Our results contribute to specify the functional meaning of the Closure Positive Shift in music, shed light on the large-scale structural integration of musical input, and raise new hypotheses concerning shared resources between music and language.

Abstract

Neuroscientific and musicological approaches to music cognition indicate that listeners familiarized in the Western tonal tradition expect a musical phrase boundary at predictable time intervals. However, phrase boundary prediction processes in music remain untested. We analyzed event-related potentials (ERPs) and event-related induced power changes at the onset and offset of a boundary pause. We made comparisons with modified melodies, where the pause was omitted and filled by tones. The offset of the pause elicited a closure positive shift (CPS), indexing phrase boundary detection. The onset of the filling tones elicited significant increases in theta and beta powers. In addition, the P2 component was larger when the filling tones started than when they ended. The responses to boundary omission suggest that listeners expected to hear a boundary pause. Therefore, boundary prediction seems to coexist with boundary detection in music segmentation.

Abstract

Multivariate pattern analysis is a technique that allows the decoding of conceptual information such as the semantic category of a perceived object from neuroimaging data. Impressive single-trial classification results have been reported in studies that used fMRI. Here, we investigate the possibility to identify conceptual representations from event-related EEG based on the presentation of an object in different modalities: its spoken name, its visual representation and its written name. We used Bayesian logistic regression with a multivariate Laplace prior for classification. Marked differences in classification performance were observed for the tested modalities. Highest accuracies (89% correctly classified trials) were attained when classifying object drawings. In auditory and orthographical modalities, results were lower though still significant for some subjects. The employed classification method allowed for a precise temporal localization of the features that contributed to the performance of the classifier for three modalities. These findings could help to further understand the mechanisms underlying conceptual representations. The study also provides a first step towards the use of concept decoding in the context of real-time brain-computer interface applications.

Abstract

An ability to decode semantic information from fMRI spatial patterns has been demonstrated in previous studies mostly for 1 specific input modality. In this study, we aimed to decode semantic category independent of the modality in which an object was presented. Using a searchlight method, we were able to predict the stimulus category from the data while participants performed a semantic categorization task with 4 stimulus modalities (spoken and written names, photographs, and natural sounds). Significant classification performance was achieved in all 4 modalities. Modality-independent decoding was implemented by training and testing the searchlight method across modalities. This allowed the localization of those brain regions, which correctly discriminated between the categories, independent of stimulus modality. The analysis revealed large clusters of voxels in the left inferior temporal cortex and in frontal regions. These voxels also allowed category discrimination in a free recall session where subjects recalled the objects in the absence of external stimuli. The results show that semantic information can be decoded from the fMRI signal independently of the input modality and have clear implications for understanding the functional mechanisms of semantic memory.

Abstract

This study examines what stage 9‐12‐year‐old Dutch‐speaking children have reached in the development of their L2 lexicon, focusing on its phonological specificity. Two experiments were carried out with a group of Dutch‐speaking children and adults learning English. In a first task, listeners were asked to judge Dutch words which were presented with either the target Dutch vowel or with an English vowel synthetically inserted. The second experiment was a mirror of the first, i.e. with English words and English or Dutch vowels inserted. It was examined to what extent the listeners accepted substitutions of Dutch vowels by English ones, and vice versa. The results of the experiments suggest that the children have not reached the same degree of phonological specificity of L2 words as the adults. Children not only experience a strong influence of their native vowel categories when listening to L2 words, they also apply less strict criteria.

Abstract

This study investigated the phonological representations of vowels in children's native and non-native lexicons. Two experiments were mispronunciation tasks (i.e., a vowel in words was substituted by another vowel from the same language). These were carried out by Dutch-speaking 9–12-year-old children and Dutch-speaking adults, in their native (Experiment 1, Dutch) and non-native (Experiment 2, English) language. A third experiment tested vowel discrimination. In Dutch, both children and adults could accurately detect mispronunciations. In English, adults, and especially children, detected substitutions of native vowels (i.e., vowels that are present in the Dutch inventory) by non-native vowels more easily than changes in the opposite direction. Experiment 3 revealed that children could accurately discriminate most of the vowels. The results indicate that children's L1 categories strongly influenced their perception of English words. However, the data also reveal a hint of the development of L2 phoneme categories.

Abstract

Aim Sex chromosome aneuploidies increase the risk of spoken or written language disorders but individuals with specific language impairment (SLI) or dyslexia do not routinely undergo cytogenetic analysis. We assess the frequency of sex chromosome aneuploidies in individuals with language impairment or dyslexia. Method Genome-wide single nucleotide polymorphism genotyping was performed in three sample sets: a clinical cohort of individuals with speech and language deficits (87 probands: 61 males, 26 females; age range 4 to 23 years), a replication cohort of individuals with SLI, from both clinical and epidemiological samples (209 probands: 139 males, 70 females; age range 4 to 17 years), and a set of individuals with dyslexia (314 probands: 224 males, 90 females; age range 7 to 18 years). Results In the clinical language-impaired cohort, three abnormal karyotypic results were identified in probands (proband yield 3.4%). In the SLI replication cohort, six abnormalities were identified providing a consistent proband yield (2.9%). In the sample of individuals with dyslexia, two sex chromosome aneuploidies were found giving a lower proband yield of 0.6%. In total, two XYY, four XXY (Klinefelter syndrome), three XXX, one XO (Turner syndrome), and one unresolved karyotype were identified. Interpretation The frequency of sex chromosome aneuploidies within each of the three cohorts was increased over the expected population frequency (approximately 0.25%) suggesting that genetic testing may prove worthwhile for individuals with language and literacy problems and normal non-verbal IQ. Early detection of these aneuploidies can provide information and direct the appropriate management for individuals.

Abstract

Crosslinguistic studies of expressions of motion events have found that Talmy's binary typology of verb-framed and satellite-framed languages is reflected in language use. In particular, Manner of motion is relatively more elaborated in satellite-framed languages (e.g., in narrative, picture description, conversation, translation). The present research builds on previous controlled studies of the domain of human motion by eliciting descriptions of a wide range of manners of walking and running filmed in natural circumstances. Descriptions were elicited from speakers of two satellite-framed languages (English, Polish) and three verb-framed languages (French, Spanish, Basque). The sampling of events in this study resulted in four major semantic clusters for these five languages: walking, running, non-canonical gaits (divided into bounce-and-recoil and syncopated movements), and quadrupedal movement (crawling). Counts of verb types found a broad tendency for satellite-framed languages to show greater lexical diversity, along with substantial within group variation. Going beyond most earlier studies, we also examined extended descriptions of manner of movement, isolating types of manner. The following categories of manner were identified and compared: attitude of actor, rate, effort, posture, and motor patterns of legs and feet. Satellite-framed speakers tended to elaborate expressive manner verbs, whereas verb-framed speakers used modification to add manner to neutral motion verbs

Abstract

Cerebellar ataxias are progressive neurodegenerative disorders characterized by atrophy of the cerebellum leading to motor dysfunction, balance problems, and limb and gait ataxia. These include among others, the dominantly inherited spinocerebellar ataxias, recessive cerebellar ataxias such as Friedreich's ataxia, and X-linked cerebellar ataxias. Since all cerebellar ataxias display considerable overlap in their disease phenotypes, common pathological pathways must underlie the selective cerebellar neurodegeneration. Therefore, it is important to identify the molecular mechanisms and routes to neurodegeneration that cause cerebellar ataxia. In this review, we discuss the use of functional genomic approaches including whole-exome sequencing, genome-wide gene expression profiling, miRNA profiling, epigenetic profiling, and genetic modifier screens to reveal the underlying pathogenesis of various cerebellar ataxias. These approaches have resulted in the identification of many disease genes, modifier genes, and biomarkers correlating with specific stages of the disease. This article is part of a Special Issue entitled: From Genome to Function.

Abstract

The effect of literacy on phonological processing has been described in terms of a virus that “infects all speech processing” (Frith, 1998). Empirical data has established that literacy leads to changes to the way in which phonological information is processed. Harm & Seidenberg (1999) demonstrated that a connectionist network trained to map between English orthographic and phonological representations display’s more componential phonological processing than a network trained only to stably represent the phonological forms of words. Within this study we use a similar model yet manipulate the transparency of orthographic-to-phonological mappings. We observe that networks trained on a transparent orthography are better at restoring phonetic features and phonemes. However, networks trained on non-transparent orthographies are more likely to restore corrupted phonological segments with legal, coarser linguistic units (e.g. onset, coda). Our study therefore provides an explicit description of how differences in orthographic transparency can lead to varying strains and symptoms of the ‘literacy virus’.

Abstract

When processing language, the cognitive system has access to information from a range of modalities (e.g. auditory, visual) to support language processing. Language mediated visual attention studies have shown sensitivity of the listener to phonological, visual, and semantic similarity when processing a word. In a computational model of language mediated visual attention, that models spoken word processing as the parallel integration of information from phonological, semantic and visual processing streams, we simulate such effects of competition within modalities. Our simulations raised untested predictions about stronger and earlier effects of visual and semantic similarity compared to phonological similarity around the rhyme of the word. Two visual world studies confirmed these predictions. The model and behavioral studies suggest that, during spoken word comprehension, multimodal information can be recruited rapidly to constrain lexical selection to the extent that phonological rhyme information may exert little influence on this process.

Abstract

Multimodal integration is a central characteristic of human cognition. However our understanding of the interaction between modalities and its influence on behaviour is still in its infancy. This paper examines the value of the Hub & Spoke framework (Plaut, 2002; Rogers et al., 2004; Dilkina et al., 2008; 2010) as a tool for exploring multimodal interaction in cognition. We present a Hub and Spoke model of language–vision information interaction and report the model’s ability to replicate a range of phonological, visual and semantic similarity word-level effects reported in the Visual World Paradigm (Cooper, 1974; Tanenhaus et al, 1995). The model provides an explicit connection between the percepts of language and the distribution of eye gaze and demonstrates the scope of the Hub-and-Spoke architectural framework by modelling new aspects of multimodal cognition.

Abstract

Learning to read and write requires an individual to connect additional orthographic representations to pre-existing mappings between phonological and semantic representations of words. Past empirical results suggest that the process of learning to read and write (at least in alphabetic languages) elicits changes in the language processing system, by either increasing the cognitive efficiency of mapping between representations associated with a word, or by changing the granularity of phonological processing of spoken language, or through a combination of both. Behavioural effects of literacy have typically been assessed in offline explicit tasks that have addressed only phonological processing. However, a recent eye tracking study compared high and low literate participants on effects of phonology and semantics in processing measured implicitly using eye movements. High literates’ eye movements were more affected by phonological overlap in online speech than low literates, with only subtle differences observed in semantics. We determined whether these effects were due to cognitive efficiency and/or granularity of speech processing in a multimodal model of speech processing – the amodal shared resource model (ASR, Smith, Monaghan, & Huettig, 2013). We found that cognitive efficiency in the model had only a marginal effect on semantic processing and did not affect performance for phonological processing, whereas fine-grained versus coarse-grained phonological representations in the model simulated the high/low literacy effects on phonological processing, suggesting that literacy has a focused effect in changing the grain-size of phonological mappings.

Abstract

We present the results of a large-scale study on speech perception, assessing the number and type of perceptual hypotheses which listeners entertain about possible phoneme sequences in their language. Dutch listeners were asked to identify gated fragments of all 1179 diphones of Dutch, providing a total of 488 520 phoneme categorizations. The results manifest orderly uptake of acoustic information in the signal. Differences across phonemes in the rate at which fully correct recognition was achieved arose as a result of whether or not potential confusions could occur with other phonemes of the language ~long with short vowels, affricates with their initial components, etc.!. These data can be used to improve models of how acoustic phonetic information is mapped onto the mental lexicon during speech comprehension.

Abstract

A quantitative model of human categorization behavior is proposed, which can be applied to 4-alternative forced-choice categorization data involving two binary classifications. A number of processing dependencies between the two classifications are explicitly formulated, such as the dependence of the location, orientation, and steepness of the class boundary for one classification on the outcome of the other classification. The significance of various types of dependencies can be tested statistically. Analyses of a data set from the literature shows that interesting dependencies in human speech recognition can be uncovered using the model.

Abstract

In a recent fMRI study we showed that left posterior middle temporal gyrus (LpMTG) subserves the retrieval of a word's lexical-syntactic properties from the mental lexicon (long-term memory), while left posterior inferior frontal gyrus (LpIFG) is involved in unifying (on-line integration of) this information into a sentence structure (Snijders et al., 2009). In addition, the right IFG, right MTG, and the right striatum were involved in the unification process. Here we report results from a psychophysical interactions (PPI) analysis in which we investigated the effective connectivity between LpIFG and LpMTG during unification, and how the right hemisphere areas and the striatum are functionally connected to the unification network. LpIFG and LpMTG both showed enhanced connectivity during the unification process with a region slightly superior to our previously reported LpMTG. Right IFG better predicted right temporal activity when unification processes were more strongly engaged, just as LpIFG better predicted left temporal activity. Furthermore, the striatum showed enhanced coupling to LpIFG and LpMTG during unification. We conclude that bilateral inferior frontal and posterior temporal regions are functionally connected during sentence-level unification. Cortico-subcortical connectivity patterns suggest cooperation between inferior frontal and striatal regions in performing unification operations on lexical-syntactic representations retrieved from LpMTG.

Abstract

Oxytocin plays an important role in monogamous pairbonded female voles, but not in polygamous voles. Here we examined a socially monogamous cooperatively breeding primate where both sexes share in parental care and territory defense for within species variation in behavior and female and male oxytocin levels in 14 pairs of cotton-top tamarins (Saguinus oedipus). In order to obtain a stable chronic assessment of hormones and behavior, we observed behavior and collected urinary hormonal samples across the tamarins’ 3-week ovulatory cycle. We found similar levels of urinary oxytocin in both sexes. However, basal urinary oxytocin levels varied 10-fold across pairs and pair-mates displayed similar oxytocin levels. Affiliative behavior (contact, grooming, sex) also varied greatly across the sample and explained more than half the variance in pair oxytocin levels. The variables accounting for variation in oxytocin levels differed by sex. Mutual contact and grooming explained most of the variance in female oxytocin levels, whereas sexual behavior explained most of the variance in male oxytocin levels. The initiation of contact by males and solicitation of sex by females were related to increased levels of oxytocin in both. This study demonstrates within-species variation in oxytocin that is directly related to levels of affiliative and sexual behavior. However, different behavioral mechanisms influence oxytocin levels in males and females and a strong pair relationship (as indexed by high levels of oxytocin) may require the activation of appropriate mechanisms for both sexes.

Abstract

We present results from cross-modal priming experiments on German participles and noun plurals. The experiments produced parallel results for both inflectional systems. Regular inflection exhibits full priming whereas irregularly inflected word forms show only partial priming: after hearing regularly inflected words (-t participles and -s plurals), lexical decision times on morphologically related word forms (presented visually) were similar to reaction times for a base-line condition in which prime and target were identical, but significantly shorter than in a control condition where prime and target were unrelated. In contrast, prior presentation of irregular words (-n participles and -er plurals) led to significantly longer response times on morphologically related word forms than the prior presentation of the target itself. Hence, there are clear priming differences between regularly and irregularly inflected German words. We compare the findings on German with experimental results on regular and irregular inflection in English and Italian, and discuss theoretical implications for single versus dual-mechanism models of inflection.

Abstract

The auditory scene is a mental representation of individual sounds extracted from the summed sound waveform reaching the ears of the listeners. Musical contexts represent particularly complex cases of auditory scenes. In such a scenario, melody may be seen as the main object moving on a background represented by the accompaniment. Both melody and accompaniment vary in time according to harmonic rules, forming a typical texture with melody in the most prominent, salient voice. In the present sparse acquisition functional magnetic resonance imaging study, we investigated the interplay between melody and accompaniment in trained pianists, by observing the activation responses elicited by processing: (1) melody placed in the upper and lower texture voices, leading to, respectively, a higher and lower auditory salience; (2) harmonic violations occurring in either the melody, the accompaniment, or both. The results indicated that the neural activation elicited by the processing of polyphonic compositions in expert musicians depends upon the upper versus lower position of the melodic line in the texture, and showed an overall greater activation for the harmonic processing of melody over accompaniment. Both these two predominant effects were characterized by the involvement of the posterior cingulate cortex and precuneus, among other associative brain regions. We discuss the prominent role of the posterior medial cortex in the processing of melodic and harmonic information in the auditory stream, and propose to frame this processing in relation to the cognitive construction of complex multimodal sensory imagery scenes.

Abstract

E-Prime, the software suite by Psychology Software Tools, is used for designing, developing and running custom psychological experiments. Aimed at students and researchers alike, this book provides a much needed, down-to-earth introduction into a wide range of experiments that can be set up using E-Prime. Many tutorials are provided to teach the reader how to develop experiments typical for the broad fields of psychological and cognitive science. Apart from explaining the basic structure of E-Prime and describing how it fits into daily scientific practice, this book also offers an introduction into programming using E-Prime’s own E-Basic language. The authors guide the readers step-by-step through the software, from an elementary to an advanced level, enabling them to benefit from the enormous possibilities for experimental design offered by E-Prime.

Abstract

This paper presents the Kachna corpus of spontaneous speech, in which ten Czech and ten Norwegian speakers were recorded both in their native language and in English. The dialogues are elicited using a picture replication task that requires active cooperation and interaction of speakers by asking them to produce a drawing as close to the original as possible. The corpus is appropriate for the study of interactional features and speech reduction phenomena across native and second languages. The combination of productions in non-native English and in speakers’ native language is advantageous for investigation of L2 issues while providing a L1 behaviour reference from all the speakers. The corpus consists of 20 dialogues comprising 12 hours 53 minutes of recording, and was collected in 2008. Preparation of the transcriptions, including a manual orthographic transcription and an automatically generated phonetic transcription, is currently in progress. The phonetic transcriptions are automatically generated by aligning acoustic models with the speech signal on the basis of the orthographic transcriptions and a dictionary of pronunciation variants compiled for the relevant language. Upon completion the corpus will be made available via the European Language Resources Association (ELRA).

Abstract

Why do people accommodate to each other’s linguistic behavior? Studies of natural interactions (Giles, Taylor & Bourhis, 1973) suggest that speakers accommodate to achieve interactional goals, influencing what their interlocutor thinks or feels about them. But is this the only reason speakers accommodate? In real-world conversations, interactional motivations are ubiquitous, making it difficult to assess the extent to which they drive accommodation. Do speakers still accommodate even when interactional goals cannot be achieved, for instance, when their interlocutor cannot interpret their accommodation behavior? To find out, we asked participants to enter an immersive virtual reality (VR) environment and to converse with a virtual interlocutor. Participants accommodated to the speech rate of their virtual interlocutor even though he could not interpret their linguistic behavior, and thus accommodation could not possibly help them to achieve interactional goals. Results show that accommodation does not require explicit interactional goals, and suggest other social motivations for accommodation.

Abstract

In this article, we propose the use of suffix arrays to efficiently implement n-gram language models with practically unlimited size n. This approach, which is used with synchronous back-off, allows us to distinguish between alternative sequences using large contexts. We also show that we can build this kind of models with additional information for each symbol, such as part-of-speech tags and dependency information. The approach can also be viewed as a collection of virtual k-testable automata. Once built, we can directly access the results of any k-testable automaton generated from the input training data. Synchronous back- off automatically identies the k-testable automaton with the largest feasible k. We have used this approach in several classification tasks.

Abstract

Finding regularities in large data sets requires implementations of systems that are efficient in both time and space requirements. Here, we describe a newly developed system that exploits the internal structure of the enhanced suffixarray to find significant patterns in a large collection of sequences. The system searches exhaustively for all significantly compressing patterns where patterns may consist of symbols and skips or wildcards. We demonstrate a possible application of the system by detecting interesting patterns in a Dutch and an English corpus.

Abstract

In this article, we propose the use of suffix arrays to implement n-gram language models with practically unlimited size n. These unbounded n-grams are called 1-grams. This approach allows us to use large contexts efficiently to distinguish between different alternative sequences while applying synchronous back-off. From a practical point of view, the approach has been applied within the context of spelling confusibles, verb and noun agreement and prenominal adjective ordering. These initial experiments show promising results and we relate the performance to the size of the n-grams used for disambiguation.

Abstract

OBJECTIVE: Genome-wide association studies (GWAS) of BMI are mostly undertaken under the assumption that "kg/m(2) " is an index of weight fully adjusted for height, but in general this is not true. The aim here was to assess the contribution of common genetic variation to a adjusted version of that phenotype which appropriately accounts for covariation in height in children. METHODS: A GWAS of height-adjusted BMI (BMI[x] = weight/height(x) ), calculated to be uncorrelated with height, in 5809 participants (mean age 9.9 years) from the Avon Longitudinal Study of Parents and Children (ALSPAC) was performed. RESULTS: GWAS based on BMI[x] yielded marked differences in genomewide results profile. SNPs in ADCY3 (adenylate cyclase 3) were associated at genome-wide significance level (rs11676272 (0.28 kg/m(3.1) change per allele G (0.19, 0.38), P = 6 × 10(-9) ). In contrast, they showed marginal evidence of association with conventional BMI [rs11676272 (0.25 kg/m(2) (0.15, 0.35), P = 6 × 10(-7) )]. Results were replicated in an independent sample, the Generation R study. CONCLUSIONS: Analysis of BMI[x] showed differences to that of conventional BMI. The association signal at ADCY3 appeared to be driven by a missense variant and it was strongly correlated with expression of this gene. Our work highlights the importance of well understood phenotype use (and the danger of convention) in characterising genetic contributions to complex traits.

Abstract

While a training model of cognitive intervention targets the improvement of particular skills through instruction and practice, an engagement model is based on the idea that being embedded in an intellectually and socially complex environment can impact cognition, perhaps even broadly, without explicit instruction. We contrasted these 2 models of cognitive enrichment by randomly assigning healthy older adults to a home-based inductive reasoning training program, a team-based competitive program in creative problem solving, or a wait-list control. As predicted, those in the training condition showed selective improvement in inductive reasoning. Those in the engagement condition, on the other hand, showed selective improvement in divergent thinking, a key ability exercised in creative problem solving. On average, then, both groups appeared to show ability-specific effects. However, moderators of change differed somewhat for those in the engagement and training interventions. Generally, those who started either intervention with a more positive cognitive profile showed more cognitive growth, suggesting that cognitive resources enabled individuals to take advantage of environmental enrichment. Only in the engagement condition did initial levels of openness and social network size moderate intervention effects on cognition, suggesting that comfort with novelty and an ability to manage social resources may be additional factors contributing to the capacity to take advantage of the environmental complexity associated with engagement. Collectively, these findings suggest that training and engagement models may offer alternative routes to cognitive resilience in late life

Abstract

This article, part of a 10 language comparative project on question–response sequences, discusses these sequences in American English conversation. The data are video-taped spontaneous naturally occurring conversations involving two to five adults. Relying on these data I document the basic distributional patterns of types of questions asked (polar, Q-word or alternative as well as sub-types), types of social actions implemented by these questions (e.g., repair initiations, requests for confirmation, offers or requests for information), and types of responses (e.g., repetitional answers or yes/no tokens). I show that declarative questions are used more commonly in conversation than would be suspected by traditional grammars of English and questions are used for a wider range of functions than grammars would suggest. Finally, this article offers distributional support for the idea that responses that are better “fitted” with the question are preferred.

Abstract

no abstract is available for this article

Abstract

Relying on the methodology of conversation analysis, this article examines a practice in ordinary conversation characterized by the resaying of a word, phrase, or sentence. The article shows that multiple sayings such as "No no no" or "Alright alright alright" are systematic in both their positioning relative to the interlocutor's talk and in their function. Specifically, the findings are that multiple sayings are a resource speakers have to display that their turn is addressing an in progress course of action rather than only the just prior utterance. Speakers of multiple sayings communicate their stance that the prior speaker has persisted unnecessarily in the prior course of action and should properly halt course of action.

Abstract

A fundamental puzzle in the organization of social interaction concerns how one individual elicits a response from another. This article asks what it is about some sequentially initial turns that reliably mobilizes a coparticipant to respond and under what circumstances individuals are accountable for producing a response. Whereas a linguistic approach suggests that this is what oquestionso (more generally) and interrogativity (more narrowly) are for, a sociological approach to social interaction suggests that the social action a person is implementing mobilizes a recipient's response. We find that although both theories have merit, neither adequately solves the puzzle. We argue instead that different actions mobilize response to different degrees. Speakers then design their turns to perform actions, and with particular response-mobilizing features of turn-design speakers can hold recipients more accountable for responding or not. This model of response relevance allows sequential position, action, and turn design to each contribute to response relevance.

Abstract

When people request information, they have a variety of means for eliciting the information. In English two of the primary resources for eliciting information include asking questions, making statements about their interlocutor (thereby generating confirmation or revision). But within these types there are a variety of ways that these information elicitors can be designed. The goal of this task is to examine how different languages seek and provide information, the extent to which syntax vs prosodic resources are used (e.g., in questions), and the extent to which the design of information seeking actions and their responses display a structural preference to promote social solidarity.

Abstract

A number of Conversation Analytic studies have documented that question recipients have a variety of ways to push against the constraints that questions impose on them. This article explores the concept of transformative answers – answers through which question recipients retroactively adjust the question posed to them. Two main sorts of adjustments are discussed: question term transformations and question agenda transformations. It is shown that the operations through which interactants implement term transformations are different from the operations through which they implement agenda transformations. Moreover, term-transforming answers resist only the question’s design, while agenda-transforming answers effectively resist both design and agenda, thus implying that agenda-transforming answers resist more strongly than design-transforming answers. The implications of these different sorts of transformations for alignment and affiliation are then explored.

Abstract

How can we understand each other during communicative interactions? An influential suggestion holds that communicators are primed by each other’s behaviors, with associative mechanisms automatically coordinating the production of communicative signals and the comprehension of their meanings. An alternative suggestion posits that mutual understanding requires shared conceptualizations of a signal’s use, i.e., “conceptual pacts” that are abstracted away from specific experiences. Both accounts predict coherent neural dynamics across communicators, aligned either to the occurrence of a signal or to the dynamics of conceptual pacts. Using coherence spectral-density analysis of cerebral activity simultaneously measured in pairs of communicators, this study shows that establishing mutual understanding of novel signals synchronizes cerebral dynamics across communicators’ right temporal lobes. This interpersonal cerebral coherence occurred only within pairs with a shared communicative history, and at temporal scales independent from signals’ occurrences. These findings favor the notion that meaning emerges from shared conceptualizations of a signal’s use.

Abstract

Despite the ambiguity inherent in human communication, people are remarkably efficient in establishing mutual understanding. Studying how people communicate in novel settings provides a window into the mechanisms supporting the human competence to rapidly generate and understand novel shared symbols, a fundamental property of human communication. Previous work indicates that the right posterior superior temporal sulcus (pSTS) is involved when people understand the intended meaning of novel communicative actions. Here, we set out to test whether normal functioning of this cerebral structure is required for understanding novel communicative actions using inhibitory low-frequency repetitive transcranial magnetic stimulation (rTMS). A factorial experimental design contrasted two tightly matched stimulation sites (right pSTS vs. left MT+, i.e. a contiguous homotopic task-relevant region) and tasks (a communicative task vs. a visual tracking task that used the same sequences of stimuli). Overall task performance was not affected by rTMS, whereas changes in task performance over time were disrupted according to TMS site and task combinations. Namely, rTMS over pSTS led to a diminished ability to improve action understanding on the basis of recent communicative history, while rTMS over MT+ perturbed improvement in visual tracking over trials. These findings qualify the contributions of the right pSTS to human communicative abilities, showing that this region might be necessary for incorporating previous knowledge, accumulated during interactions with a communicative partner, to constrain the inferential process that leads to action understanding.

Abstract

Developmental studies show that it takes longer for
children learning spoken languages to acquire viewpointdependent
spatial relations (e.g., left-right, front-behind),
compared to ones that are not viewpoint-dependent (e.g.,
in, on, under). The current study investigates how
children learn to express viewpoint-dependent relations
in a sign language where depicted spatial relations can be
communicated in an analogue manner in the space in
front of the body or by using body-anchored signs (e.g.,
tapping the right and left hand/arm to mean left and
right). Our results indicate that the visual-spatial
modality might have a facilitating effect on learning to
express these spatial relations (especially in encoding of
left-right) in a sign language (i.e., Turkish Sign
Language) compared to a spoken language (i.e.,
Turkish).

Abstract

Spoken language comprehension requires rapid integration of information from multiple linguistic sources. In the present study we addressed the temporal aspects of this integration process by focusing on the time course of the selection of the appropriate meaning of lexical ambiguities (“bank”) in sentence contexts. Successful selection of the contextually appropriate meaning of the ambiguous word is dependent upon the rapid binding of the contextual information in the sentence to the appropriate meaning of the ambiguity. We used the N400 to identify the time course of this binding process. The N400 was measured to target words that followed three types of context sentences. In the concordant context, the sentence biased the meaning of the sentence-final ambiguous word so that it was related to the target. In the discordant context, the sentence context biased the meaning so that it was not related to the target. In the unrelated control condition, the sentences ended in an unambiguous noun that was unrelated to the target. Half of the concordant sentences biased the dominant meaning, and the other half biased the subordinate meaning of the sentence-final ambiguous words. The ISI between onset of the target word and offset of the sentence-final word of the context sentence was 100 ms in one version of the experiment, and 1250 ms in the second version. We found that (i) the lexically dominant meaning is always partly activated, independent of context, (ii) initially both dominant and subordinate meaning are (partly) activated, which suggests that contextual and lexical factors both contribute to sentence interpretation without context completely overriding lexical information, and (iii) strong lexical influences remain present for a relatively long period of time.

Abstract

This study investigates whether spoken sentence comprehension deficits in Broca's aphasics results from their inability to access the subordinate meaning of ambiguous words (e.g. bank), or alternatively, from a delay in their selection of the contextually appropriate meaning. Twelve Broca's aphasics and twelve elderly controls were presented with lexical ambiguities in three context conditions, each followed by the same target words. In the concordant condition, the sentence context biased the meaning of the sentence final ambiguous word that was related to the target. In the discordant condition, the sentence context biased the meaning of the sentence final ambiguous word that was incompatible with the target.In the unrelated condition, the sentence-final word was unambiguous and unrelated to the target. The task of the subjects was to listen attentively to the stimuli The activational status of the ambiguous sentence-final words was inferred from the amplitude of the N399 to the targets at two inter-stimulus intervals (ISIs) (100 ms and 1250 ms). At the short ISI, the Broca's aphasics showed clear evidence of activation of the subordinate meaning. In contrast to elderly controls, however, the Broca's aphasics were not successful at selecting the appropriate meaning of the ambiguity in the short ISI version of the experiment. But at the long ISI, in accordance with the performance of the elderly controls, the patients were able to successfully complete the contextual selection process. These results indicate that Broca's aphasics are delayed in the process of contextual selection. It is argued that this finding of delayed selection is compatible with the idea that comprehension deficits in Broca's aphasia result from a delay in the process of integrating lexical information.

Abstract

We investigate how the lexical nature of weak definites influences the phenomenon of direct object scrambling in Dutch. Earlier experiments have indicated that weak definites are more resistant to scrambling than strong definites. We examine how the notion of weak definiteness used in this experimental work can be reduced to lexical connectedness. We explore four different ways of quantifying the relation between a direct object and the verb. Our results show that predictability of a verb given the object (verb cloze probability) provides the best fit to the weak/strong distinction used in the earlier experiments

Abstract

This volume on Inuit speech follows the evolution of a native language of the North American Arctic, from its historical roots to its present-day linguistic structure and patterns of use from Alaska to Greenland. Drawing on a wide range of research from the fields of linguistics, anthropology, and sociology, Dorais integrates these diverse perspectives in a comprehensive view of native language development, maintenance, and use under conditions of marginalization due to social transition.

Abstract

Although infants show remarkable sensitivity to linguistically relevant phonetic variation in speech, young children sometimes appear not to make use of this sensitivity. Here, children's knowledge of the sound-forms of familiar words was assessed using a visual fixation task. Dutch 19-month-olds were shown pairs of pictures and heard correct pronunciations and mispronunciations of familiar words naming one of the pictures. Mispronunciations were word-initial in Experiment 1 and word-medial in Experiment 2, and in both experiments involved substituting one segment with [d] (a common sound in Dutch) or [g] (a rare sound). In both experiments, word recognition performance was better for correct pronunciations than for mispronunciations involving either substituted consonant. These effects did not depend upon children's knowledge of lexical or nonlexical phonological neighbors of the tested words. The results indicate the encoding of phonetic detail in words at 19 months.

Abstract

Four cross-modal repetition priming experiments examined whether consonant duration in Italian provides listeners with information not only for segmental identification ("what" information: whether the consonant is a geminate or a singleton) but also for lexical segmentation (“where” information: whether the consonant is in word-initial or word-medial position). Italian participants made visual lexical decisions to words containing geminates or singletons, preceded by spoken primes (whole words or fragments) containing either geminates or singletons. There were effects of segmental identity (geminates primed geminate recognition; singletons primed singleton recognition), and effects of consonant position (regression analyses revealed graded effects of geminate duration only for geminates which can vary in position, and mixed-effect modeling revealed a positional effect for singletons only in low-frequency words). Durational information appeared to be more important for segmental identification than for lexical segmentation. These findings nevertheless indicate that the same kind of information can serve both "what" and "where" functions in speech comprehension, and that the perceptual processes underlying those functions are interdependent.

Abstract

To investigate the neural underpinnings of word decoding, and how it changes as a function of repeated exposure, we trained Dutch participants repeatedly over the course of a month of training to articulate a set of novel disyllabic input strings written in Greek script to avoid the use of familiar orthographic representations. The syllables in the input were phonotactically legal combinations but non-existent in the Dutch language, allowing us to assess their role in novel word decoding. Not only trained disyllabic pseudowords were tested but also pseudowords with recombined patterns of syllables to uncover the emergence of syllabic representations. We showed that with extensive training, articulation became faster and more accurate for the trained pseudowords. On the neural level, the initial stage of decoding was reflected by increased activity in visual attention areas of occipito-temporal and occipito-parietal cortices, and in motor coordination areas of the precentral gyrus and the inferior frontal gyrus. After one month of training, memory representations for holistic information (whole word unit) were established in areas encompassing the angular gyrus, the precuneus and the middle temporal gyrus. Syllabic representations also emerged through repeated training of disyllabic pseudowords, such that reading recombined syllables of the trained pseudowords showed similar brain activation to trained pseudowords and were articulated faster than novel combinations of letter strings used in the trained pseudowords.

Abstract

The complementary learning systems account of declarative memory suggests two distinct memory networks, a fast-mapping, episodic system involving the hippocampus, and a slower semantic memory system distributed across the neocortex in which new information is gradually integrated with existing representations. In this study, we investigated the extent to which these two networks are involved in the integration of novel words into the lexicon after extensive learning, and how the involvement of these networks changes after 24 hours. In particular, we explored whether having richer information at encoding influences the lexicalization trajectory. We trained participants with two sets of novel words, one where exposure was only to the words’ phonological forms (the form-only condition), and one where pictures of unfamiliar objects were associated with the words’ phonological forms (the picture-associated condition). A behavioral measure of lexical competition (indexing lexicalization) indicated stronger competition effects for the form-only words. Imaging (fMRI) results revealed greater involvement of phonological lexical processing areas immediately after training in the form-only condition, suggesting tight connections were formed between novel words and existing lexical entries already at encoding. Retrieval of picture-associated novel words involved the episodic/hippocampal memory system more extensively. Although lexicalization was weaker in the picture-associated condition, overall memory strength was greater when tested after a 24 hours’ delay, probably due to the availability of both episodic and lexical memory networks to aid retrieval. It appears that, during lexicalization of a novel word, the relative involvement of different memory networks differs according to the richness of the information about that word available at encoding.

Abstract

Purpose: Delayed auditory feedback is a technique that can improve fluency in stutterers, while disrupting fluency in many non-stuttering individuals. The aim of this study was to determine the neural basis for the detection of and compensation for such a delay, and the effects of increases in the delay duration. Method: Positron emission tomography (PET) was used to image regional cerebral blood flow changes, an index of neural activity, and assessed the influence of increasing amounts of delay. Results: Delayed auditory feedback led to increased activation in the bilateral superior temporal lobes, extending into posterior-medial auditory areas. Similar peaks in the temporal lobe were sensitive to increases in the amount of delay. A single peak in the temporal parietal junction responded to the amount of delay but not to the presence of a delay (relative to no delay). Conclusions: This study permitted distinctions to be made between the neural response to hearing one's voice at a delay, and the neural activity that correlates with this delay. Notably all the peaks showed some influence of the amount of delay. This result confirms a role for the posterior, sensori-motor ‘how’ system in the production of speech under conditions of delayed auditory feedback.

Abstract

Not unlike the tonal system in Chinese, Japanese habitually attaches pitch accents to the production of words. However, in contrast to Chinese, few homophonic word-pairs are really distinguished by pitch accents (Shibata & Shibata, 1990). This predicts that pitch accent plays a small role in lexical selection for Japanese language comprehension. The present study investigated whether native Japanese speakers necessarily use pitch accent in the processing of accent-contrasted homophonic pairs (e.g., ame [LH] for 'candy' and ame [HI] for 'rain') measuring electroencephalographic (EEG) potentials. Electrophysiological evidence (i.e., N400) was obtained when a word was semantically incorrect for a given context but not for incorrectly accented homophones. This suggests that pitch accent indeed plays a minor role when understanding Japanese. (C) 2013 Elsevier Ltd. All rights reserved.

Abstract

The murine homologue of the human chloride channel gene, CLCN5, defects in which are responsible for Dent disease, has been cloned and characterized. We isolated the entire coding region of mouse Clcn5 cDNA and approximately 45 kb of genomic sequence embracing the gene. To study its transcriptional control, the 5' upstream sequences of the mouse Clcn5 gene were cloned into a luciferase reporter vector. Deletion analysis of 1.5 kb of the 5' flanking sequence defined an active promoter region within 128 bp of the putative transcription start site, which is associated with a TATA motif but lacks a CAAT consensus. Within this sequence, there is a motif with homology to a purine-rich sequence responsible for the kidney-specific promoter activity of the rat CLC-K1 gene, another member of the chloride-channel gene family expressed in kidney. An enhancer element that confers a 10- to 20-fold increase in the promoter activity of the mouse Clcn5 gene was found within the first intron. The organization of the human CLCN5 and mouse Clcn5 gene structures is highly conserved, and the sequence of the murine protein is 98% similar to that of human, with its highest expression seen in the kidney. This study thus provides the first identification of the transcriptional control region of, and the basis for an understanding of the regulatory mechanism that controls, this kidney-specific, chloride-channel gene.