Publications

Displaying 1601 - 1660 of 1660
  • Weber, A. (1998). Listening to nonnative language which violates native assimilation rules. In D. Duez (Ed.), Proceedings of the European Scientific Communication Association workshop: Sound patterns of Spontaneous Speech (pp. 101-104).

    Abstract

    Recent studies using phoneme detection tasks have shown that spoken-language processing is neither facilitated nor interfered with by optional assimilation, but is inhibited by violation of obligatory assimilation. Interpretation of these results depends on an assessment of their generality, specifically, whether they also obtain when listeners are processing nonnative language. Two separate experiments are presented in which native listeners of German and native listeners of Dutch had to detect a target fricative in legal monosyllabic Dutch nonwords. All of the nonwords were correct realisations in standard Dutch. For German listeners, however, half of the nonwords contained phoneme strings which violate the German fricative assimilation rule. Whereas the Dutch listeners showed no significant effects, German listeners detected the target fricative faster when the German fricative assimilation was violated than when no violation occurred. The results might suggest that violation of assimilation rules does not have to make processing more difficult per se.
  • Weber, A., & Crocker, M. W. (2012). On the nature of semantic constraints on lexical access. Journal of Psycholinguistic Research, 41, 195-214. doi:10.1007/s10936-011-9184-0.

    Abstract

    We present two eye-tracking experiments that investigate lexical frequency and semantic context constraints in spoken-word recognition in German. In both experiments, the pivotal words were pairs of nouns overlapping at onset but varying in lexical frequency. In Experiment 1, German listeners showed an expected frequency bias towards high-frequency competitors (e.g., Blume, ‘flower’) when instructed to click on low-frequency targets (e.g., Bluse, ‘blouse’). In Experiment 2, semantically constraining context increased the availability of appropriate low-frequency target words prior to word onset, but did not influence the availability of semantically inappropriate high-frequency competitors at the same time. Immediately after target word onset, however, the activation of high-frequency competitors was reduced in semantically constraining sentences, but still exceeded that of unrelated distractor words significantly. The results suggest that (1) semantic context acts to downgrade activation of inappropriate competitors rather than to exclude them from competition, and (2) semantic context influences spoken-word recognition, over and above anticipation of upcoming referents.
  • Weber, A., & Broersma, M. (2012). Spoken word recognition in second language acquisition. In C. A. Chapelle (Ed.), The encyclopedia of applied linguistics. Bognor Regis: Wiley-Blackwell. doi:10.1002/9781405198431.wbeal1104.

    Abstract

    In order to decode the message of a speaker, listeners have to recognize individual words in the speaker's utterance.
  • Weber, K., & Indefrey, P. (2009). Syntactic priming in German–English bilinguals during sentence comprehension. Neuroimage, 46, 1164-1172. doi:10.1016/j.neuroimage.2009.03.040.

    Abstract

    A longstanding question in bilingualism is whether syntactic information is shared between the two language processing systems. We used an fMRI repetition suppression paradigm to investigate syntactic priming in reading comprehension in German–English late-acquisition bilinguals. In comparison to conventional subtraction analyses in bilingual experiments, repetition suppression has the advantage of being able to detect neuronal populations that are sensitive to properties that are shared by consecutive stimuli. In this study, we manipulated the syntactic structure between prime and target sentences. A sentence with a passive sentence structure in English was preceded either by a passive or by an active sentence in English or German. We looked for repetition suppression effects in left inferior frontal, left precentral and left middle temporal regions of interest. These regions were defined by a contrast of all non-target sentences in German and English versus the baseline of sentence-format consonant strings. We found decreases in activity (repetition suppression effects) in these regions of interest following the repetition of syntactic structure from the first to the second language and within the second language.
    Moreover, a separate behavioural experiment using a word-by-word reading paradigm similar to the fMRI experiment showed faster reading times for primed compared to unprimed English target sentences regardless of whether they were preceded by an English or a German sentence of the same structure.
    We conclude that there is interaction between the language processing systems and that at least some syntactic information is shared between a bilingual's languages with similar syntactic structures.

    Files private

    Request files
  • Weber, A. (2009). The role of linguistic experience in lexical recognition [Abstract]. Journal of the Acoustical Society of America, 125, 2759.

    Abstract

    Lexical recognition is typically slower in L2 than in L1. Part of the difficulty comes from a not precise enough processing of L2 phonemes. Consequently, L2 listeners fail to eliminate candidate words that L1 listeners can exclude from competing for recognition. For instance, the inability to distinguish /r/ from /l/ in rocket and locker makes for Japanese listeners both words possible candidates when hearing their onset (e.g., Cutler, Weber, and Otake, 2006). The L2 disadvantage can, however, be dispelled: For L2 listeners, but not L1 listeners, L2 speech from a non-native talker with the same language background is known to be as intelligible as L2 speech from a native talker (e.g., Bent and Bradlow, 2003). A reason for this may be that L2 listeners have ample experience with segmental deviations that are characteristic for their own accent. On this account, only phonemic deviations that are typical for the listeners’ own accent will cause spurious lexical activation in L2 listening (e.g., English magic pronounced as megic for Dutch listeners). In this talk, I will present evidence from cross-modal priming studies with a variety of L2 listener groups, showing how the processing of phonemic deviations is accent-specific but withstands fine phonetic differences.
  • Weber, K. (2012). The language learning brain: Evidence from second language learning and bilingual studies of syntactic processing. PhD Thesis, Radboud University Nijmegen, Nijmegen.

    Abstract

    Many people speak a second language next to their mother tongue. How do they learn this language and how does the brain process it compared to the native language? A second language can be learned without explicit instruction. Our brains automatically pick up grammatical structures, such as word order, when these structures are repeated frequently during learning. The learning takes place within hours or days and the same brain areas, such as frontal and temporal brain regions, that process our native language are very quickly activated. When people master a second language very well, even the same neuronal populations in these language brain areas are involved. This is especially the case when the grammatical structures are similar. In conclusion, it appears that a second language builds on the existing cognitive and neural mechanisms of the native language as much as possible.
  • Weber, A., Melinger, A., & Lara Tapia, L. (2007). The mapping of phonetic information to lexical presentations in Spanish: Evidence from eye movements. In J. Trouvain, & W. J. Barry (Eds.), Proceedings of the 16th International Congress of Phonetic Sciences (ICPhS 2007) (pp. 1941-1944). Dudweiler: Pirrot.

    Abstract

    In a visual-world study, we examined spoken-wordrecognition in Spanish. Spanish listeners followed spoken instructions to click on pictures while their eye movements were monitored. When instructed to click on the picture of a door (puerta), they experienced interference from the picture of a pig (p u e r c o ). The same interference from phonologically related items was observed when the displays contained printed names or a combination of pictures with their names printed underneath, although the effect was strongest for displays with printed names. Implications of the finding that the interference effect can be induced with standard pictorial displays as well as with orthographic displays are discussed.
  • Wells, J. B., Christiansen, M. H., Race, D. S., Acheson, D. J., & MacDonald, M. C. (2009). Experience and sentence processing: Statistical learning and relative clause comprehension. Cognitive Psychology, 58(2), 250-271. doi:10.1016/j.cogpsych.2008.08.002.

    Abstract

    Many explanations of the difficulties associated with interpreting object relative clauses appeal to the demands that object relatives make on working memory. MacDonald and Christiansen [MacDonald, M. C., & Christiansen, M. H. (2002). Reassessing working memory: Comment on Just and Carpenter (1992) and Waters and Caplan (1996). Psychological Review, 109, 35-54] pointed to variations in reading experience as a source of differences, arguing that the unique word order of object relatives makes their processing more difficult and more sensitive to the effects of previous experience than the processing of subject relatives. This hypothesis was tested in a large-scale study manipulating reading experiences of adults over several weeks. The group receiving relative clause experience increased reading speeds for object relatives more than for subject relatives, whereas a control experience group did not. The reading time data were compared to performance of a computational model given different amounts of experience. The results support claims for experience-based individual differences and an important role for statistical learning in sentence comprehension processes.
  • Whelpton, M., Guðmundsdóttir Beck, þ., & Jordan, F. (2015). The semantics and morphology of household container names in Icelandic and Dutch. Language Sciences, 49, 67-81. doi:10.1016/j.langsci.2014.07.014.

    Abstract

    In this paper, we report an experiment on the naming of household containers in Dutch and Icelandic carried out as part of the Evolution of Semantic Systems project (EoSS; Majid et al., 2011). This naming experiment allows us to support and elaborate on a hypothesis by Malt et al. (2003) that productive morphology in the naming domain can have an influence on boundary placement within the extensional space. Specifically, we demonstrate that the Dutch diminutive -(t)je favours a cut between small items versus others, whereas Icelandic, which does not use the diminutive in this domain, favours a cut between large items and others. This is not a typological effect, as Dutch and Icelandic are both Germanic languages and both have diminutive morphology available in principle. We find no evidence that the diminutive produces a proliferation of terms and/or fine-grained nesting within the extensional domain. Rather, the Dutch diminutive favours a more even distribution of terms across the space whereas Icelandic favours broad inclusive terms with a number of narrower specialist terms. Further, the extensional space defined by the diminutive is not associated with its own clear prototypical exemplar. Using evidence from compounding and modification, we also consider which semantic features are prominent in differentiating categories within the domain. By far the most prominent in both languages is the inferred contents of the container. Other than contents, however, the languages differ in the range and prominence of features such as intended usage or material of composition. Our results demonstrate that in order to understand the processes that produce semantic divisions of basic object classes, we should consider fine-grained analyses of closely related languages alongside analyses of typologically different languages.
  • Whitehouse, A. J., Bishop, D. V., Ang, Q., Pennell, C. E., & Fisher, S. E. (2012). Corrigendum to CNTNAP2 variants affect early language development in the general population. Genes, Brain and Behavior, 11, 501. doi:10.1111/j.1601-183X.2012.00806.x.

    Abstract

    Corrigendum to CNTNAP2 variants affect early language development in the general population A. J. O. Whitehouse, D. V. M. Bishop, Q. W. Ang, C. E. Pennell and S. E. Fisher Genes Brain Behav (2011) doi: 10.1111/j.1601-183X.2011.00684.x. The authors have detected a typographical error in the Abstract of this paper. The error is in the fifth sentence, which reads: ‘‘On the basis of these findings, we performed analyses of four-marker haplotypes of rs2710102–rs759178–rs17236239–rs2538976 and identified significant association (haplotype TTAA, P = 0.049; haplotype GCAG,P = .0014).’’ Rather than ‘‘GCAG’’, the final haplotype should read ‘‘CGAG’’. This typographical error was made in the Abstract only and this has no bearing on the results or conclusions of the study, which remain unchanged. Reference Whitehouse, A. J. O., Bishop, D. V. M., Ang, Q. W., Pennell, C. E. & Fisher, S. E. (2011) CNTNAP2 variants affect early language development in the general population. Genes Brain Behav 10, 451–456. doi: 10.1111/j.1601-183X.2011.00684.x.
  • Whitehouse, H., & Cohen, E. (2012). Seeking a rapprochement between anthropology and the cognitive sciences: A problem-driven approach. Topics in Cognitive Science, 4, 404-412. doi:10.1111/j.1756-8765.2012.01203.x.

    Abstract

    Beller, Bender, and Medin question the necessity of including social anthropology within the cognitive sciences. We argue that there is great scope for fruitful rapprochement while agreeing that there are obstacles (even if we might wish to debate some of those specifically identified by Beller and colleagues). We frame the general problem differently, however: not in terms of the problem of reconciling disciplines and research cultures, but rather in terms of the prospects for collaborative deployment of expertise (methodological and theoretical) in problem-driven research. For the purposes of illustration, our focus in this article is on the evolution of cooperation
  • Whorf, B. L. (2012). Language, thought, and reality: selected writings of Benjamin Lee Whorf [2nd ed.]: introduction by John B. Carroll; foreword by Stephen C. Levinson. (J. B. Carroll, S. C. Levinson, & P. Lee, Eds.). Cambridge, MA: MIT Press.

    Abstract

    The pioneering linguist Benjamin Whorf (1897–1941) grasped the relationship between human language and human thinking: how language can shape our innermost thoughts. His basic thesis is that our perception of the world and our ways of thinking about it are deeply influenced by the structure of the languages we speak. The writings collected in this volume include important papers on the Maya, Hopi, and Shawnee languages, as well as more general reflections on language and meaning. Whorf’s ideas about the relation of language and thought have always appealed to a wide audience, but their reception in expert circles has alternated between dismissal and applause. Recently the language sciences have headed in directions that give Whorf’s thinking a renewed relevance. Hence this new edition of Whorf’s classic work is especially timely. The second edition includes all the writings from the first edition as well as John Carroll’s original introduction, a new foreword by Stephen Levinson of the Max Planck Institute for Psycholinguistics that puts Whorf’s work in historical and contemporary context, and new indexes. In addition, this edition offers Whorf’s “Yale Report,” an important work from Whorf’s mature oeuvre.
  • Wilkins, D., Kita, S., & Enfield, N. J. (2007). 'Ethnography of pointing' - field worker's guide. In A. Majid (Ed.), Field Manual Volume 10 (pp. 89-95). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.492922.

    Abstract

    Pointing gestures are recognised to be a primary manifestation of human social cognition and communicative capacity. The goal of this task is to collect empirical descriptions of pointing practices in different cultural settings.
  • Willems, R. M., Ozyurek, A., & Hagoort, P. (2007). When language meets action: The neural integration of gesture and speech. Cerebral Cortex, 17(10), 2322-2333. doi:10.1093/cercor/bhl141.

    Abstract

    Although generally studied in isolation, language and action often co-occur in everyday life. Here we investigated one particular form of simultaneous language and action, namely speech and gestures that speakers use in everyday communication. In a functional magnetic resonance imaging study, we identified the neural networks involved in the integration of semantic information from speech and gestures. Verbal and/or gestural content could be integrated easily or less easily with the content of the preceding part of speech. Premotor areas involved in action observation (Brodmann area [BA] 6) were found to be specifically modulated by action information "mismatching" to a language context. Importantly, an increase in integration load of both verbal and gestural information into prior speech context activated Broca's area and adjacent cortex (BA 45/47). A classical language area, Broca's area, is not only recruited for language-internal processing but also when action observation is integrated with speech. These findings provide direct evidence that action and language processing share a high-level neural integration system.
  • Willems, R. M., Toni, I., Hagoort, P., & Casasanto, D. (2009). Body-specific motor imagery of hand actions: Neural evidence from right- and left-handers. Frontiers in Human Neuroscience, 3: 39, pp. 39. doi:10.3389/neuro.09.039.2009.

    Abstract

    If motor imagery uses neural structures involved in action execution, then the neural correlates of imagining an action should differ between individuals who tend to execute the action differently. Here we report fMRI data showing that motor imagery is influenced by the way people habitually perform motor actions with their particular bodies; that is, motor imagery is ‘body-specific’ (Casasanto, 2009). During mental imagery for complex hand actions, activation of cortical areas involved in motor planning and execution was left-lateralized in right-handers but right-lateralized in left-handers. We conclude that motor imagery involves the generation of an action plan that is grounded in the participant’s motor habits, not just an abstract representation at the level of the action’s goal. People with different patterns of motor experience form correspondingly different neurocognitive representations of imagined actions.
  • Willems, R. M., & Hagoort, P. (2009). Broca's region: Battles are not won by ignoring half of the facts. Trends in Cognitive Sciences, 13(3), 101. doi:10.1016/j.tics.2008.12.001.
  • Willems, R. M., & Francken, J. C. (2012). Embodied cognition: Taking the next step. Frontiers in Psychology, 3, 582. doi:10.3389/fpsyg.2012.00582.

    Abstract

    Recent years have seen a large amount of empirical studies related to ‘embodied cognition’. While interesting and valuable, there is something dissatisfying with the current state of affairs in this research domain. Hypotheses tend to be underspecified, testing in general terms for embodied versus disembodied processing. The lack of specificity of current hypotheses can easily lead to an erosion of the embodiment concept, and result in a situation in which essentially any effect is taken as positive evidence. Such erosion is not helpful to the field and does not do justice to the importance of embodiment. Here we want to take stock, and formulate directions for how it can be studied in a more fruitful fashion. As an example we will describe few example studies that have investigated the role of sensori-motor systems in the coding of meaning (‘embodied semantics’). Instead of focusing on the dichotomy between embodied and disembodied theories, we suggest that the field move forward and ask how and when sensori-motor systems and behavior are involved in cognition.
  • Willems, R. M., Ozyurek, A., & Hagoort, P. (2009). Differential roles for left inferior frontal and superior temporal cortex in multimodal integration of action and language. Neuroimage, 47, 1992-2004. doi:10.1016/j.neuroimage.2009.05.066.

    Abstract

    Several studies indicate that both posterior superior temporal sulcus/middle temporal gyrus (pSTS/MTG) and left inferior frontal gyrus (LIFG) are involved in integrating information from different modalities. Here we investigated the respective roles of these two areas in integration of action and language information. We exploited the fact that the semantic relationship between language and different forms of action (i.e. co-speech gestures and pantomimes) is radically different. Speech and co-speech gestures are always produced together, and gestures are not unambiguously understood without speech. On the contrary, pantomimes are not necessarily produced together with speech and can be easily understood without speech. We presented speech together with these two types of communicative hand actions in matching or mismatching combinations to manipulate semantic integration load. Left and right pSTS/MTG were only involved in semantic integration of speech and pantomimes. Left IFG on the other hand was involved in integration of speech and co-speech gestures as well as of speech and pantomimes. Effective connectivity analyses showed that depending upon the semantic relationship between language and action, LIFG modulates activation levels in left pSTS.

    This suggests that integration in pSTS/MTG involves the matching of two input streams for which there is a relatively stable common object representation, whereas integration in LIFG is better characterized as the on-line construction of a new and unified representation of the input streams. In conclusion, pSTS/MTG and LIFG are differentially involved in multimodal integration, crucially depending upon the semantic relationship between the input streams.

    Additional information

    Supplementary table S1
  • Willems, R. M. (Ed.). (2015). Cognitive neuroscience of natural language use. Cambridge: Cambridge University Press.
  • Willems, R. M. (2015). Cognitive neuroscience of natural language use: Introduction. In Cognitive neuroscience of natural language use (pp. 1-7). Cambridge: Cambridge University Press.
  • Willems, R. M., & Hagoort, P. (2007). Neural evidence for the interplay between language, gesture, and action: A review. Brain and Language, 101(3), 278-289. doi:10.1016/j.bandl.2007.03.004.

    Abstract

    Co-speech gestures embody a form of manual action that is tightly coupled to the language system. As such, the co-occurrence of speech and co-speech gestures is an excellent example of the interplay between language and action. There are, however, other ways in which language and action can be thought of as closely related. In this paper we will give an overview of studies in cognitive neuroscience that examine the neural underpinnings of links between language and action. Topics include neurocognitive studies of motor representations of speech sounds, action-related language, sign language and co-speech gestures. It will be concluded that there is strong evidence on the interaction between speech and gestures in the brain. This interaction however shares general properties with other domains in which there is interplay between language and action.
  • Willems, R. M., & Hagoort, P. (2009). Hand preference influences neural correlates of action observation. Brain Research, 1269, 90-104. doi:10.1016/j.brainres.2009.02.057.

    Abstract

    It has been argued that we map observed actions onto our own motor system. Here we added to this issue by investigating whether hand preference influences the neural correlates of action observation of simple, essentially meaningless hand actions. Such an influence would argue for an intricate neural coupling between action production and action observation, which goes beyond effects of motor repertoire or explicit motor training, as has been suggested before. Indeed, parts of the human motor system exhibited a close coupling between action production and action observation. Ventral premotor and inferior and superior parietal cortices showed differential activation for left- and right-handers that was similar during action production as well as during action observation. This suggests that mapping observed actions onto the observer's own motor system is a core feature of action observation - at least for actions that do not have a clear goal or meaning. Basic differences in the way we act upon the world are not only reflected in neural correlates of action production, but can also influence the brain basis of action observation.
  • Willems, R. M. (2009). Neural reflections of meaning in gesture, language, and action. PhD Thesis, Radboud University Nijmegen, Nijmegen.
  • Willems, R. M. (2007). The neural construction of a Tinkertoy [‘Journal club’ review]. The Journal of Neuroscience, 27, 1509-1510. doi:10.1523/JNEUROSCI.0005-07.2007.
  • Windhouwer, M., Broeder, D., & Van Uytvanck, D. (2012). A CMD core model for CLARIN web services. In Proceedings of LREC 2012: 8th International Conference on Language Resources and Evaluation (pp. 41-48).

    Abstract

    In the CLARIN infrastructure various national projects have started initiatives to allow users of the infrastructure to create chains or workflows of web services. The Component Metadata (CMD) core model for web services described in this paper tries to align the metadata descriptions of these various initiatives. This should allow chaining/workflow engines to find matching and invoke services. The paper describes the landscape of web services architectures and the state of the national initiatives. Based on this a CMD core model for CLARIN is proposed, which, within some limits, can be adapted to the specific needs of an initiative by the standard facilities of CMD. The paper closes with the current state and usage of the model and a look into the future.
  • Windhouwer, M., & Wright, S. E. (2012). Linking to linguistic data categories in ISOcat. In C. Chiarcos, S. Nordhoff, & S. Hellmann (Eds.), Linked data in linguistics: Representing and connecting language data and language metadata (pp. 99-107). Berlin: Springer.

    Abstract

    ISO Technical Committee 37, Terminology and other language and content resources, established an ISO 12620:2009 based Data Category Registry (DCR), called ISOcat (see http://www.isocat.org), to foster semantic interoperability of linguistic resources. However, this goal can only be met if the data categories are reused by a wide variety of linguistic resource types. A resource indicates its usage of data categories by linking to them. The small DC Reference XML vocabulary is used to embed links to data categories in XML documents. The link is established by an URI, which servers as the Persistent IDentifier (PID) of a data category. This paper discusses the efforts to mimic the same approach for RDF-based resources. It also introduces the RDF quad store based Relation Registry RELcat, which enables ontological relationships between data categories not supported by ISOcat and thus adds an extra level of linguistic knowledge.
  • Windhouwer, M. (2012). RELcat: a Relation Registry for ISOcat data categories. In N. Calzolari (Ed.), Proceedings of LREC 2012: 8th International Conference on Language Resources and Evaluation (pp. 3661-3664). European Language Resources Association (ELRA).

    Abstract

    The ISOcat Data Category Registry contains basically a flat and easily extensible list of data category specifications. To foster reuse and standardization only very shallow relationships among data categories are stored in the registry. However, to assist crosswalks, possibly based on personal views, between various (application) domains and to overcome possible proliferation of data categories more types of ontological relationships need to be specified. RELcat is a first prototype of a Relation Registry, which allows storing arbitrary relationships. These relationships can reflect the personal view of one linguist or a larger community. The basis of the registry is a relation type taxonomy that can easily be extended. This allows on one hand to load existing sets of relations specified in, for example, an OWL (2) ontology or SKOS taxonomy. And on the other hand allows algorithms that query the registry to traverse the stored semantic network to remain ignorant of the original source vocabulary. This paper describes first experiences with RELcat and explains some initial design decisions.
  • Windhouwer, M. (2012). Towards standardized descriptions of linguistic features: ISOcat and procedures for using common data categories. In J. Jancsary (Ed.), Proceedings of the Conference on Natural Language Processing 2012, (SFLR 2012 workshop), September 19-21, 2012, Vienna (pp. 494). Vienna: Österreichischen Gesellschaft für Artificial Intelligende (ÖGAI).

    Abstract

    Automatic Language Identification of written texts is a well-established area of research in Computational Linguistics. State-of-the-art algorithms often rely on n-gram character models to identify the correct language of texts, with good results seen for European languages. In this paper we propose the use of a character n-gram model and a word n-gram language model for the automatic classification of two written varieties of Portuguese: European and Brazilian. Results reached 0.998 for accuracy using character 4-grams.
  • De Wit, S. J., van der Werf, Y. D., Mataix-Cols, D., Trujillo, J. P., van Oppen, P., Veltman, D. J., & van den Heuvel, O. A. (2015). Emotion regulation before and after transcranial magnetic stimulation in obsessive compulsive disorder. Psychological Medicine, 45(14), 3059-3073. doi:10.1017/S0033291715001026.

    Abstract

    Impaired emotion regulation may underlie exaggerated emotional reactivity in patients with obsessive compulsive disorder (OCD), yet instructed emotion regulation has never been studied in the disorder. METHOD: This study aimed to assess the neural correlates of emotion processing and regulation in 43 medication-free OCD patients and 38 matched healthy controls, and additionally test if these can be modulated by stimulatory (patients) and inhibitory (controls) repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (dlPFC). Participants performed an emotion regulation task during functional magnetic resonance imaging before and after a single session of randomly assigned real or sham rTMS. Effect of group and rTMS were assessed on self-reported distress ratings and brain activity in frontal-limbic regions of interest. RESULTS: Patients had higher distress ratings than controls during emotion provocation, but similar rates of distress reduction after voluntary emotion regulation. OCD patients compared with controls showed altered amygdala responsiveness during symptom provocation and diminished left dlPFC activity and frontal-amygdala connectivity during emotion regulation. Real v. sham dlPFC stimulation differentially modulated frontal-amygdala connectivity during emotion regulation in OCD patients. CONCLUSIONS: We propose that the increased emotional reactivity in OCD may be due to a deficit in emotion regulation caused by a failure of cognitive control exerted by the dorsal frontal cortex. Modulatory rTMS over the left dlPFC may influence automatic emotion regulation capabilities by influencing frontal-limbic connectivity.
  • Withers, P. (2012). Metadata management with Arbil. In V. Arranz, D. Broeder, B. Gaiffe, M. Gavrilidou, & M. Monachini (Eds.), Proceedings of LREC 2012: 8th International Conference on Language Resources and Evaluation (pp. 72-75). European Language Resources Association (ELRA).

    Abstract

    Arbil is an application designed to create and manage metadata for research data and to arrange this data into a structure appropriate for archiving. The metadata is displayed in tables, which allows an overview of the metadata and the ability to populate and update many metadata sections in bulk. Both IMDI and Clarin metadata formats are supported and Arbil has been designed as a local application so that it can also be used offline, for instance in remote field sites. The metadata can be entered in any order or at any stage that the user is able; once the metadata and its data are ready for archiving and an Internet connection is available it can be exported from Arbil and in the case of IMDI it can then be transferred to the main archive via LAMUS (archive management and upload system).
  • Wittek, A. (1998). Learning verb meaning via adverbial modification: Change-of-state verbs in German and the adverb "wieder" again. In A. Greenhill, M. Hughes, H. Littlefield, & H. Walsh (Eds.), Proceedings of the 22nd Annual Boston University Conference on Language Development (pp. 779-790). Somerville, MA: Cascadilla Press.
  • Witteman, M. J., Bardhan, N. P., Weber, A., & McQueen, J. M. (2015). Automaticity and stability of adaptation to foreign-accented speech. Language and Speech, 52(2), 168-189. doi:10.1177/0023830914528102.

    Abstract

    In three cross-modal priming experiments we asked whether adaptation to a foreign-accented speaker is automatic, and whether adaptation can be seen after a long delay between initial exposure and test. Dutch listeners were exposed to a Hebrew-accented Dutch speaker with two types of Dutch words: those that contained [ɪ] (globally accented words), and those in which the Dutch [i] was shortened to [ɪ] (specific accent marker words). Experiment 1, which served as a baseline, showed that native Dutch participants showed facilitatory priming for globally accented, but not specific accent, words. In experiment 2, participants performed a 3.5-minute phoneme monitoring task, and were tested on their comprehension of the accented speaker 24 hours later using the same cross-modal priming task as in experiment 1. During the phoneme monitoring task, listeners were asked to detect a consonant that was not strongly accented. In experiment 3, the delay between exposure and test was extended to 1 week. Listeners in experiments 2 and 3 showed facilitatory priming for both globally accented and specific accent marker words. Together, these results show that adaptation to a foreign-accented speaker can be rapid and automatic, and can be observed after a prolonged delay in testing.
  • Wittenburg, P., Lenkiewicz, P., Auer, E., Gebre, B. G., Lenkiewicz, A., & Drude, S. (2012). AV Processing in eHumanities - a paradigm shift. In J. C. Meister (Ed.), Digital Humanities 2012 Conference Abstracts. University of Hamburg, Germany; July 16–22, 2012 (pp. 538-541).

    Abstract

    Introduction Speech research saw a dramatic change in paradigm in the 90-ies. While earlier the discussion was dominated by a phoneticians’ approach who knew about phenomena in the speech signal, the situation completely changed after stochastic machinery such as Hidden Markov Models [1] and Artificial Neural Networks [2] had been introduced. Speech processing was now dominated by a purely mathematic approach that basically ignored all existing knowledge about the speech production process and the perception mechanisms. The key was now to construct a large enough training set that would allow identifying the many free parameters of such stochastic engines. In case that the training set is representative and the annotations of the training sets are widely ‘correct’ we could assume to get a satisfyingly functioning recognizer. While the success of knowledge-based systems such as Hearsay II [3] was limited, the statistically based approach led to great improvements in recognition rates and to industrial applications.
  • Wittenburg, P., Drude, S., & Broeder, D. (2012). Psycholinguistik. In H. Neuroth, S. Strathmann, A. Oßwald, R. Scheffel, J. Klump, & J. Ludwig (Eds.), Langzeitarchivierung von Forschungsdaten. Eine Bestandsaufnahme (pp. 83-108). Boizenburg: Verlag Werner Hülsbusch.

    Abstract

    5.1 Einführung in den Forschungsbereich Die Psycholinguistik ist der Bereich der Linguistik, der sich mit dem Zusammenhang zwischen menschlicher Sprache und dem Denken und anderen mentalen Prozessen beschäftigt, d.h. sie stellt sich einer Reihe von essentiellen Fragen wie etwa (1) Wie schafft es unser Gehirn, im Wesentlichen akustische und visuelle kommunikative Informationen zu verstehen und in mentale Repräsentationen umzusetzen? (2) Wie kann unser Gehirn einen komplexen Sachverhalt, den wir anderen übermitteln wollen, in eine von anderen verarbeitbare Sequenz von verbalen und nonverbalen Aktionen umsetzen? (3) Wie gelingt es uns, in den verschiedenen Phasen des Lebens Sprachen zu erlernen? (4) Sind die kognitiven Prozesse der Sprachverarbeitung universell, obwohl die Sprachsysteme derart unterschiedlich sind, dass sich in den Strukturen kaum Universalien finden lassen?
  • Wnuk, E., & Majid, A. (2012). Olfaction in a hunter-gatherer society: Insights from language and culture. In N. Miyake, D. Peebles, & R. P. Cooper (Eds.), Proceedings of the 34th Annual Meeting of the Cognitive Science Society (CogSci 2012) (pp. 1155-1160). Austin, TX: Cognitive Science Society.

    Abstract

    According to a widely-held view among various scholars, olfaction is inferior to other human senses. It is also believed by many that languages do not have words for describing smells. Data collected among the Maniq, a small population of nomadic foragers in southern Thailand, challenge the above claims and point to a great linguistic and cultural elaboration of odor. This article presents evidence of the importance of olfaction in indigenous rituals and beliefs, as well as in the lexicon. The results demonstrate the richness and complexity of the domain of smell in Maniq society and thereby challenge the universal paucity of olfactory terms and insignificance of olfaction for humans.
  • Li, Q., Wojciechowski, R., Simpson, C. L., Hysi, P. G., Verhoeven, V. J. M., Ikram, M. K., Höhn, R., Vitart, V., Hewitt, A. W., Oexle, K., Mäkelä, K.-M., MacGregor, S., Pirastu, M., Fan, Q., Cheng, C.-Y., St Pourcain, B., McMahon, G., Kemp, J. P., Northstone, K., Rahi, J. S. and 69 moreLi, Q., Wojciechowski, R., Simpson, C. L., Hysi, P. G., Verhoeven, V. J. M., Ikram, M. K., Höhn, R., Vitart, V., Hewitt, A. W., Oexle, K., Mäkelä, K.-M., MacGregor, S., Pirastu, M., Fan, Q., Cheng, C.-Y., St Pourcain, B., McMahon, G., Kemp, J. P., Northstone, K., Rahi, J. S., Cumberland, P. M., Martin, N. G., Sanfilippo, P. G., Lu, Y., Wang, Y. X., Hayward, C., Polašek, O., Campbell, H., Bencic, G., Wright, A. F., Wedenoja, J., Zeller, T., Schillert, A., Mirshahi, A., Lackner, K., Yip, S. P., Yap, M. K. H., Ried, J. S., Gieger, C., Murgia, F., Wilson, J. F., Fleck, B., Yazar, S., Vingerling, J. R., Hofman, A., Uitterlinden, A., Rivadeneira, F., Amin, N., Karssen, L., Oostra, B. A., Zhou, X., Teo, Y.-Y., Tai, E. S., Vithana, E., Barathi, V., Zheng, Y., Siantar, R. G., Neelam, K., Shin, Y., Lam, J., Yonova-Doing, E., Venturini, C., Hosseini, S. M., Wong, H.-S., Lehtimäki, T., Kähönen, M., Raitakari, O., Timpson, N. J., Evans, D. M., Khor, C.-C., Aung, T., Young, T. L., Mitchell, P., Klein, B., van Duijn, C. M., Meitinger, T., Jonas, J. B., Baird, P. N., Mackey, D. A., Wong, T. Y., Saw, S.-M., Pärssinen, O., Stambolian, D., Hammond, C. J., Klaver, C. C. W., Williams, C., Paterson, A. D., Bailey-Wilson, J. E., & Guggenheim, J. A. (2015). Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium. Human Genetics, 134, 131-146. doi:10.1007/s00439-014-1500-y.

    Abstract

    To identify genetic variants associated with refractive astigmatism in the general population, meta-analyses of genome-wide association studies were performed for: White Europeans aged at least 25 years (20 cohorts, N = 31,968); Asian subjects aged at least 25 years (7 cohorts, N = 9,295); White Europeans aged <25 years (4 cohorts, N = 5,640); and all independent individuals from the above three samples combined with a sample of Chinese subjects aged <25 years (N = 45,931). Participants were classified as cases with refractive astigmatism if the average cylinder power in their two eyes was at least 1.00 diopter and as controls otherwise. Genome-wide association analysis was carried out for each cohort separately using logistic regression. Meta-analysis was conducted using a fixed effects model. In the older European group the most strongly associated marker was downstream of the neurexin-1 (NRXN1) gene (rs1401327, P = 3.92E−8). No other region reached genome-wide significance, and association signals were lower for the younger European group and Asian group. In the meta-analysis of all cohorts, no marker reached genome-wide significance: The most strongly associated regions were, NRXN1 (rs1401327, P = 2.93E−07), TOX (rs7823467, P = 3.47E−07) and LINC00340 (rs12212674, P = 1.49E−06). For 34 markers identified in prior GWAS for spherical equivalent refractive error, the beta coefficients for genotype versus spherical equivalent, and genotype versus refractive astigmatism, were highly correlated (r = −0.59, P = 2.10E−04). This work revealed no consistent or strong genetic signals for refractive astigmatism; however, the TOX gene region previously identified in GWAS for spherical equivalent refractive error was the second most strongly associated region. Analysis of additional markers provided evidence supporting widespread genetic co-susceptibility for spherical and astigmatic refractive errors.
  • Wolf, M. C. (2015). Het verschil tussen hardop en stillezen wat betreft leessnelheid en tekstbegrip en de invloed hierop van fonologisch bewustzijn, benoemsnelheid en visuele aandachtsspanne. Student Undergraduate Research E-journal, 1(1), 261-264. Retrieved from http://journals.library.tudelft.nl/index.php/sure/article/view/1025.

    Abstract

    In het onderwijs wordt aangenomen dat hardop en stillezen dezelfde processen zijn. In dit onderzoek wordt gekeken naar het verschil tussen hardop en stillezen wat betreft leessnelheid en tekstbegrip bij 90 kinderen uit groep 4. Ook wordt de invloed van de cognitieve vaardigheden fonologisch bewustzijn, benoemsnelheid en visuele aandachtsspanne op de verschillende leesmodi onderzocht. De participanten lazen stil sneller, maar begrepen de tekst beter hardop. De cognitieve vaardigheden correleerden met hardop en stillezen wat betreft leessnelheid, maar hingen in beide leesmodi niet samen met tekstbegrip. Hoewel hardop en stillezen samenhangen, onderstrepen deze bevindingen dat het verschillende leesmodi zijn.
  • Womelsdorf, T., Schoffelen, J.-M., Oostenveld, R., Singer, W., Desimone, R., Engel, A. K., & Fries, P. (2007). Modulation of neuronal interactions through neuronal synchronization. Science, 316, 1609-1612. doi:10.1126/science.1139597.

    Abstract

    Brain processing depends on the interactions between neuronal groups. Those interactions are governed by the pattern of anatomical connections and by yet unknown mechanisms that modulate the effective strength of a given connection. We found that the mutual influence among neuronal groups depends on the phase relation between rhythmic activities within the groups. Phase relations supporting interactions between the groups preceded those interactions by a few milliseconds, consistent with a mechanistic role. These effects were specific in time, frequency, and space, and we therefore propose that the pattern of synchronization flexibly determines the pattern of neuronal interactions.
  • Won, S.-O., Hu, I., Kim, M.-Y., Bae, J.-M., Kim, Y.-M., & Byun, K.-S. (2009). Theory and practice of Sign Language interpretation. Pyeongtaek: Korea National College of Rehabilitation & Welfare.
  • Wood, N. (2009). Field recording for dummies. In A. Majid (Ed.), Field manual volume 12 (pp. V). Nijmegen: Max Planck Institute for Psycholinguistics.
  • Xiang, H., Van Leeuwen, T. M., Dediu, D., Roberts, L., Norris, D. G., & Hagoort, P. (2015). L2-proficiency-dependent laterality shift in structural connectivity of brain language pathways. Brain Connectivity, 5(6), 349-361. doi:10.1089/brain.2013.0199.

    Abstract

    Diffusion tensor imaging (DTI) and a longitudinal language learning approach were applied to investigate the relationship between the achieved second language (L2) proficiency during L2 learning and the reorganization of structural connectivity between core language areas. Language proficiency tests and DTI scans were obtained from German students before and after they completed an intensive 6-week course of the Dutch language. In the initial learning stage, with increasing L2 proficiency, the hemispheric dominance of the BA6-temporal pathway (mainly along the arcuate fasciculus) shifted from the left to the right hemisphere. With further increased proficiency, however, lateralization dominance was again found in the left BA6-temporal pathway. This result is consistent with reports in the literature that imply a stronger involvement of the right hemisphere in L2-processing especially for less proficient L2-speakers. This is the first time that a L2-proficiency-dependent laterality shift in structural connectivity of language pathways during L2 acquisition has been observed to shift from left to right, and back to left hemisphere dominance with increasing L2-proficiency. We additionally find that changes in fractional anisotropy values after the course are related to the time elapsed between the two scans. The results suggest that structural connectivity in (at least part of) the perisylvian language network may be subject to fast dynamic changes following language learning
  • Xiang, H., Dediu, D., Roberts, L., Van Oort, E., Norris, D., & Hagoort, P. (2012). The structural connectivity underpinning language aptitude, working memory and IQ in the perisylvian language network. Language Learning, 62(Supplement S2), 110-130. doi:10.1111/j.1467-9922.2012.00708.x.

    Abstract

    We carried out the first study on the relationship between individual language aptitude and structural connectivity of language pathways in the adult brain. We measured four components of language aptitude (vocabulary learning, VocL; sound recognition, SndRec; sound-symbol correspondence, SndSym; and grammatical inferencing, GrInf) using the LLAMA language aptitude test (Meara, 2005). Spatial working memory (SWM), verbal working memory (VWM) and IQ were also measured as control factors. Diffusion Tensor Imaging (DTI) was employed to investigate the structural connectivity of language pathways in the perisylvian language network. Principal Component Analysis (PCA) on behavioural measures suggests that a general ability might be important to the first stages of L2 acquisition. It also suggested that VocL, SndSy and SWM are more closely related to general IQ than SndRec and VocL, and distinguished the tasks specifically designed to tap into L2 acquisition (VocL, SndRec,SndSym and GrInf) from more generic measures (IQ, SWM and VWM). Regression analysis suggested significant correlations between most of these behavioural measures and the structural connectivity of certain language pathways, i.e., VocL and BA47-Parietal pathway, SndSym and inter-hemispheric BA45 pathway, GrInf and BA45-Temporal pathway and BA6-Temporal pathway, IQ and BA44-Parietal pathway, BA47-Parietal pathway, BA47-Temporal pathway and inter-hemispheric BA45 pathway, SWM and inter-hemispheric BA6 pathway and BA47-Parietal pathway, and VWM and BA47-Temporal pathway. These results are discussed in relation to relevant findings in the literature.
  • Xiang, H. (2012). The language networks of the brain. PhD Thesis, Radboud University Nijmegen, Nijmegen.

    Abstract

    In recent decades, neuroimaging studies on the neural infrastructure of language are usually (or mostly) conducted with certain on-line language processing tasks. These functional neuroimaging studies helped to localize the language areas in the brain and to investigate the brain activity during explicit language processing. However, little is known about what is going on with the language areas when the brain is ‘at rest’, i.e., when there is no explicit language processing running. Taking advantage of the fcMRI and DTI techniques, this thesis is able to investigate the language function ‘off-line’ at the neuronal network level and the connectivity among language areas in the brain. Based on patient studies, the traditional, classical model on the perisylvian language network specifies a “Broca’ area – Arcuate Fasciculus – Werinicke’s area” loop (Ojemann 1991). With the help of modern neuroimaging techniques, researchers have been able to track language pathways that involve more brain structures than are in the classical model, and relate them to certain language functions. In such a background, a large part of this thesis made a contribution to the study of the topology of the language networks. It revealed that the language networks form a topographical functional connectivity pattern in the left hemisphere for the right-handers. This thesis also revealed the importance of structural hubs, such as Broca’s and Wernicke’s areas, which have more connectivity to other brain areas and play a central role in the language networks. Furthermore, this thesis revealed both functionally and structurally lateralized language networks in the brain. The consistency between what is found in this thesis and what has been known from previous functional studies seems to suggest, that the human brain is optimized and ‘ready’ for the language function even when there is currently no explicit language-processing running.
  • Xiao, M., Kong, X., Liu, J., & Ning, J. (2009). TMBF: Bloom filter algorithms of time-dependent multi bit-strings for incremental set. In Proceedings of the 2009 International Conference on Ultra Modern Telecommunications & Workshops.

    Abstract

    Set is widely used as a kind of basic data structure. However, when it is used for large scale data set the cost of storage, search and transport is overhead. The bloom filter uses a fixed size bit string to represent elements in a static set, which can reduce storage space and search cost that is a fixed constant. The time-space efficiency is achieved at the cost of a small probability of false positive in membership query. However, for many applications the space savings and locating time constantly outweigh this drawback. Dynamic bloom filter (DBF) can support concisely representation and approximate membership queries of dynamic set instead of static set. It has been proved that DBF not only possess the advantage of standard bloom filter, but also has better features when dealing with dynamic set. This paper proposes a time-dependent multiple bit-strings bloom filter (TMBF) which roots in the DBF and targets on dynamic incremental set. TMBF uses multiple bit-strings in time order to present a dynamic increasing set and uses backward searching to test whether an element is in a set. Based on the system logs from a real P2P file sharing system, the evaluation shows a 20% reduction in searching cost compared to DBF.
  • You, W., Zhang, Q., & Verdonschot, R. G. (2012). Masked syllable priming effects in word and picture naming in Chinese. PLoS One, 7(10): e46595. doi:10.1371/journal.pone.0046595.

    Abstract

    Four experiments investigated the role of the syllable in Chinese spoken word production. Chen, Chen and Ferrand (2003) reported a syllable priming effect when primes and targets shared the first syllable using a masked priming paradigm in Chinese. Our Experiment 1 was a direct replication of Chen et al.'s (2003) Experiment 3 employing CV (e. g., /ba2.ying2/, strike camp) and CVG (e. g., /bai2.shou3/, white haired) syllable types. Experiment 2 tested the syllable priming effect using different syllable types: e. g., CV (/qi4.qiu2/, balloon) and CVN (/qing1.ting2/, dragonfly). Experiment 3 investigated this issue further using line drawings of common objects as targets that were preceded either by a CV (e. g., /qi3/, attempt), or a CVN (e. g., /qing2/, affection) prime. Experiment 4 further examined the priming effect by a comparison between CV or CVN priming and an unrelated priming condition using CV-NX (e. g., /mi2.ni3/, mini) and CVN-CX (e. g., /min2.ju1/, dwellings) as target words. These four experiments consistently found that CV targets were named faster when preceded by CV primes than when they were preceded by CVG, CVN or unrelated primes, whereas CVG or CVN targets showed the reverse pattern. These results indicate that the priming effect critically depends on the match between the structure of the prime and that of the first syllable of the target. The effect obtained in this study was consistent across different stimuli and different tasks (word and picture naming), and provides more conclusive and consistent data regarding the role of the syllable in Chinese speech production.
  • Zampieri, M., & Gebre, B. G. (2012). Automatic identification of language varieties: The case of Portuguese. In J. Jancsary (Ed.), Proceedings of the Conference on Natural Language Processing 2012, September 19-21, 2012, Vienna (pp. 233-237). Vienna: Österreichischen Gesellschaft für Artificial Intelligende (ÖGAI).

    Abstract

    Automatic Language Identification of written texts is a well-established area of research in Computational Linguistics. State-of-the-art algorithms often rely on n-gram character models to identify the correct language of texts, with good results seen for European languages. In this paper we propose the use of a character n-gram model and a word n-gram language model for the automatic classification of two written varieties of Portuguese: European and Brazilian. Results reached 0.998 for accuracy using character 4-grams.
  • Zampieri, M., Gebre, B. G., & Diwersy, S. (2012). Classifying pluricentric languages: Extending the monolingual model. In Proceedings of SLTC 2012. The Fourth Swedish Language Technology Conference. Lund, October 24-26, 2012 (pp. 79-80). Lund University.

    Abstract

    This study presents a new language identification model for pluricentric languages that uses n-gram language models at the character and word level. The model is evaluated in two steps. The first step consists of the identification of two varieties of Spanish (Argentina and Spain) and two varieties of French (Quebec and France) evaluated independently in binary classification schemes. The second step integrates these language models in a six-class classification with two Portuguese varieties.
  • Zeshan, U., & De Vos, C. (Eds.). (2012). Sign languages in village communities: Anthropological and linguistic insights. Berlin: Mouton de Gruyter.

    Abstract

    The book is a unique collection of research on sign languages that have emerged in rural communities with a high incidence of, often hereditary, deafness. These sign languages represent the latest addition to the comparative investigation of languages in the gestural modality, and the book is the first compilation of a substantial number of different "village sign languages".Written by leading experts in the field, the volume uniquely combines anthropological and linguistic insights, looking at both the social dynamics and the linguistic structures in these village communities. The book includes primary data from eleven different signing communities across the world, including results from Jamaica, India, Turkey, Thailand, and Bali. All known village sign languages are endangered, usually because of pressure from larger urban sign languages, and some have died out already. Ironically, it is often the success of the larger sign language communities in urban centres, their recognition and subsequent spread, which leads to the endangerment of these small minority sign languages. The book addresses this specific type of language endangerment, documentation strategies, and other ethical issues pertaining to these sign languages on the basis of first-hand experiences by Deaf fieldworkers
  • Zhang, Y., Yurovsky, D., & Yu, C. (2015). Statistical word learning is a continuous process: Evidence from the human simulation paradigm. In D. Noelle, R. Dale, A. Warlaumont, J. Yoshimi, T. Matlock, C. D. Jennings, & P. P. Maglio (Eds.), Proceedings of the 37th Annual Meeting of the Cognitive Science Society (CogSci 2015) (pp. 2422-2427). Austin: Cognitive Science Society.

    Abstract

    In the word-learning domain, both adults and young children are able to find the correct referent of a word from highly ambiguous contexts that involve many words and objects by computing distributional statistics across the co-occurrences of words and referents at multiple naming moments (Yu & Smith, 2007; Smith & Yu, 2008). However, there is still debate regarding how learners accumulate distributional information to learn object labels in natural learning environments, and what underlying learning mechanism learners are most likely to adopt. Using the Human Simulation Paradigm (Gillette, Gleitman, Gleitman & Lederer, 1999), we found that participants’ learning performance gradually improved and that their ability to remember and carry over partial knowledge from past learning instances facilitated subsequent learning. These results support the statistical learning model that word learning is a continuous process.
  • Zhao, H., Zhou, W., Yao, Z., Wan, Y., Cao, J., Zhang, L., Zhao, J., Li, H., Zhou, R., Li, B., Wei, G., Zhang, Z., French, C. A., Dekker, J. D., Yang, Y., Fisher, S. E., Tucker, H. O., & Guo, X. (2015). Foxp1/2/4 regulate endochondral ossification as a suppresser complex. Developmental Biology, 398, 242-254. doi:10.1016/j.ydbio.2014.12.007.

    Abstract

    Osteoblast induction and differentiation in developing long bones is dynamically controlled by the opposing action of transcriptional activators and repressors. In contrast to the long list of activators that have been discovered over past decades, the network of repressors is not well-defined. Here we identify the expression of Foxp1/2/4 proteins, comprised of Forkhead-box (Fox) transcription factors of the Foxp subfamily, in both perichondrial skeletal progenitors and proliferating chondrocytes during endochondral ossification. Mice carrying loss-of-function and gain-of-function Foxp mutations had gross defects in appendicular skeleton formation. At the cellular level, over-expression of Foxp1/2/4 in chondroctyes abrogated osteoblast formation and chondrocyte hypertrophy. Conversely, single or compound deficiency of Foxp1/2/4 in skeletal progenitors or chondrocytes resulted in premature osteoblast differentiation in the perichondrium, coupled with impaired proliferation, survival, and hypertrophy of chondrocytes in the growth plate. Foxp1/2/4 and Runx2 proteins interacted in vitro and in vivo, and Foxp1/2/4 repressed Runx2 transactivation function in heterologous cells. This study establishes Foxp1/2/4 proteins as coordinators of osteogenesis and chondrocyte hypertrophy in developing long bones and suggests that a novel transcriptional repressor network involving Foxp1/2/4 may regulate Runx2 during endochondral ossification.
  • Zhen, Z., Yang, Z., Huang, L., Kong, X., Wang, X., Dang, X., Huang, Y., Song, Y., & Liu, J. (2015). Quantifying interindividual variability and asymmetry of face-selective regions: A probabilistic functional atlas. NeuroImage, 113, 13-25. doi:10.1016/j.neuroimage.2015.03.010.

    Abstract

    Face-selective regions (FSRs) are among the most widely studied functional regions in the human brain. However, individual variability of the FSRs has not been well quantified. Here we use functional magnetic resonance imaging (fMRI) to localize the FSRs and quantify their spatial and functional variabilities in 202 healthy adults. The occipital face area (OFA), posterior and anterior fusiform face areas (pFFA and aFFA), posterior continuation of the superior temporal sulcus (pcSTS), and posterior and anterior STS (pSTS and aSTS) were delineated for each individual with a semi-automated procedure. A probabilistic atlas was constructed to characterize their interindividual variability, revealing that the FSRs were highly variable in location and extent across subjects. The variability of FSRs was further quantified on both functional (i.e., face selectivity) and spatial (i.e., volume, location of peak activation, and anatomical location) features. Considerable interindividual variability and rightward asymmetry were found in all FSRs on these features. Taken together, our work presents the first effort to characterize comprehensively the variability of FSRs in a large sample of healthy subjects, and invites future work on the origin of the variability and its relation to individual differences in behavioral performance. Moreover, the probabilistic functional atlas will provide an adequate spatial reference for mapping the face network.
  • Zhou, W. (2015). Assessing birth language memory in young adoptees. PhD Thesis, Radboud University Nijmegen, Nijmegen.
  • Zhu, Z., Hagoort, P., Zhang, J. X., Feng, G., Chen, H.-C., Bastiaansen, M. C. M., & Wang, S. (2012). The anterior left inferior frontal gyrus contributes to semantic unification. NeuroImage, 60, 2230-2237. doi:10.1016/j.neuroimage.2012.02.036.

    Abstract

    Semantic unification, the process by which small blocks of semantic information are combined into a coherent utterance, has been studied with various types of tasks. However, whether the brain activations reported in these studies are attributed to semantic unification per se or to other task-induced concomitant processes still remains unclear. The neural basis for semantic unification in sentence comprehension was examined using event-related potentials (ERP) and functional Magnetic Resonance Imaging (fMRI). The semantic unification load was manipulated by varying the goodness of fit between a critical word and its preceding context (in high cloze, low cloze and violation sentences). The sentences were presented in a serial visual presentation mode. The participants were asked to perform one of three tasks: semantic congruency judgment (SEM), silent reading for comprehension (READ), or font size judgment (FONT), in separate sessions. The ERP results showed a similar N400 amplitude modulation by the semantic unification load across all of the three tasks. The brain activations associated with the semantic unification load were found in the anterior left inferior frontal gyrus (aLIFG) in the FONT task and in a widespread set of regions in the other two tasks. These results suggest that the aLIFG activation reflects a semantic unification, which is different from other brain activations that may reflect task-specific strategic processing.

    Additional information

    Zhu_2012_suppl.dot
  • Ziegler, A., DeStefano, A. L., König, I. R., Bardel, C., Brinza, D., Bull, S., Cai, Z., Glaser, B., Jiang, W., Lee, K. E., Li, C. X., Li, J., Li, X., Majoram, P., Meng, Y., Nicodemus, K. K., Platt, A., Schwarz, D. F., Shi, W., Shugart, Y. Y. and 7 moreZiegler, A., DeStefano, A. L., König, I. R., Bardel, C., Brinza, D., Bull, S., Cai, Z., Glaser, B., Jiang, W., Lee, K. E., Li, C. X., Li, J., Li, X., Majoram, P., Meng, Y., Nicodemus, K. K., Platt, A., Schwarz, D. F., Shi, W., Shugart, Y. Y., Stassen, H. H., Sun, Y. V., Won, S., Wang, W., Wahba, G., Zagaar, U. A., & Zhao, Z. (2007). Data mining, neural nets, trees–problems 2 and 3 of Genetic Analysis Workshop 15. Genetic Epidemiology, 31(Suppl 1), S51-S60. doi:10.1002/gepi.20280.

    Abstract

    Genome-wide association studies using thousands to hundreds of thousands of single nucleotide polymorphism (SNP) markers and region-wide association studies using a dense panel of SNPs are already in use to identify disease susceptibility genes and to predict disease risk in individuals. Because these tasks become increasingly important, three different data sets were provided for the Genetic Analysis Workshop 15, thus allowing examination of various novel and existing data mining methods for both classification and identification of disease susceptibility genes, gene by gene or gene by environment interaction. The approach most often applied in this presentation group was random forests because of its simplicity, elegance, and robustness. It was used for prediction and for screening for interesting SNPs in a first step. The logistic tree with unbiased selection approach appeared to be an interesting alternative to efficiently select interesting SNPs. Machine learning, specifically ensemble methods, might be useful as pre-screening tools for large-scale association studies because they can be less prone to overfitting, can be less computer processor time intensive, can easily include pair-wise and higher-order interactions compared with standard statistical approaches and can also have a high capability for classification. However, improved implementations that are able to deal with hundreds of thousands of SNPs at a time are required.
  • Zora, H., Schwarz, I.-C., & Heldner, M. (2015). Neural correlates of lexical stress: Mismatch negativity reflects fundamental frequency and intensity. NeuroReport, 26(13), 791-796. doi:10.1097/WNR.0000000000000426.

    Abstract

    Neural correlates of lexical stress were studied using the mismatch negativity (MMN) component in event-related potentials. The MMN responses were expected to reveal the encoding of stress information into long-term memory and the contributions of prosodic features such as fundamental frequency (F0) and intensity toward lexical access. In a passive oddball paradigm, neural responses to changes in F0, intensity, and in both features together were recorded for words and pseudowords. The findings showed significant differences not only between words and pseudowords but also between prosodic features. Early processing of prosodic information in words was indexed by an intensity-related MMN and an F0-related P200. These effects were stable at right-anterior and mid-anterior regions. At a later latency, MMN responses were recorded for both words and pseudowords at the mid-anterior and posterior regions. The P200 effect observed for F0 at the early latency for words developed into an MMN response. Intensity elicited smaller MMN for pseudowords than for words. Moreover, a larger brain area was recruited for the processing of words than for the processing of pseudowords. These findings suggest earlier and higher sensitivity to prosodic changes in words than in pseudowords, reflecting a language-related process. The present study, therefore, not only establishes neural correlates of lexical stress but also confirms the presence of long-term memory traces for prosodic information in the brain.
  • Zwaan, R. A., Van der Stoep, N., Guadalupe, T., & Bouwmeester, S. (2012). Language comprehension in the balance: The robustness of the action-compatibility effect (ACE). PLoS One, 7(2), e31204. doi:10.1371/journal.pone.0031204.

    Abstract

    How does language comprehension interact with motor activity? We investigated the conditions under which comprehending an action sentence affects people's balance. We performed two experiments to assess whether sentences describing forward or backward movement modulate the lateral movements made by subjects who made sensibility judgments about the sentences. In one experiment subjects were standing on a balance board and in the other they were seated on a balance board that was mounted on a chair. This allowed us to investigate whether the action compatibility effect (ACE) is robust and persists in the face of salient incompatibilities between sentence content and subject movement. Growth-curve analysis of the movement trajectories produced by the subjects in response to the sentences suggests that the ACE is indeed robust. Sentence content influenced movement trajectory despite salient inconsistencies between implied and actual movement. These results are interpreted in the context of the current discussion of embodied, or grounded, language comprehension and meaning representation.
  • Zwitserlood, I. (2012). Classifiers. In R. Pfau, M. Steinbach, & B. Woll (Eds.), Sign Language: an International Handbook (pp. 158-186). Berlin: Mouton de Gruyter.

    Abstract

    Classifiers (currently also called 'depicting handshapes'), are observed in almost all signed languages studied to date and form a well-researched topic in sign language linguistics. Yet, these elements are still subject to much debate with respect to a variety of matters. Several different categories of classifiers have been posited on the basis of their semantics and the linguistic context in which they occur. The function(s) of classifiers are not fully clear yet. Similarly, there are differing opinions regarding their structure and the structure of the signs in which they appear. Partly as a result of comparison to classifiers in spoken languages, the term 'classifier' itself is under debate. In contrast to these disagreements, most studies on the acquisition of classifier constructions seem to consent that these are difficult to master for Deaf children. This article presents and discusses all these issues from the viewpoint that classifiers are linguistic elements.
  • Zwitserlood, I., Perniss, P. M., & Ozyurek, A. (2012). An empirical investigation of expression of multiple entities in Turkish Sign Language (TİD): Considering the effects of modality. Lingua, 122, 1636 -1667. doi:10.1016/j.lingua.2012.08.010.

    Abstract

    This paper explores the expression of multiple entities in Turkish Sign Language (Türk İşaret Dili; TİD), a less well-studied sign language. It aims to provide a comprehensive description of the ways and frequencies in which entity plurality in this language is expressed, both within and outside the noun phrase. We used a corpus that includes both elicited and spontaneous data from native signers. The results reveal that most of the expressions of multiple entities in TİD are iconic, spatial strategies (i.e. localization and spatial plural predicate inflection) none of which, we argue, should be considered as genuine plural marking devices with the main aim of expressing plurality. Instead, the observed devices for localization and predicate inflection allow for a plural interpretation when multiple locations in space are used. Our data do not provide evidence that TİD employs (productive) morphological plural marking (i.e. reduplication) on nouns, in contrast to some other sign languages and many spoken languages. We relate our findings to expression of multiple entities in other signed languages and in spoken languages and discuss these findings in terms of modality effects on expression of multiple entities in human language.
  • Zwitserlood, I. (2009). Het Corpus NGT. Levende Talen Magazine, 6, 44-45.

    Abstract

    The Corpus NGT
  • Zwitserlood, I. (2009). Het Corpus NGT en de dagelijkse lespraktijk (1). Levende Talen Magazine, 8, 40-41.

Share this page