Publications

Displaying 1801 - 1838 of 1838
  • Wittenburg, P., Lenkiewicz, P., Auer, E., Gebre, B. G., Lenkiewicz, A., & Drude, S. (2012). AV Processing in eHumanities - a paradigm shift. In J. C. Meister (Ed.), Digital Humanities 2012 Conference Abstracts. University of Hamburg, Germany; July 16–22, 2012 (pp. 538-541).

    Abstract

    Introduction Speech research saw a dramatic change in paradigm in the 90-ies. While earlier the discussion was dominated by a phoneticians’ approach who knew about phenomena in the speech signal, the situation completely changed after stochastic machinery such as Hidden Markov Models [1] and Artificial Neural Networks [2] had been introduced. Speech processing was now dominated by a purely mathematic approach that basically ignored all existing knowledge about the speech production process and the perception mechanisms. The key was now to construct a large enough training set that would allow identifying the many free parameters of such stochastic engines. In case that the training set is representative and the annotations of the training sets are widely ‘correct’ we could assume to get a satisfyingly functioning recognizer. While the success of knowledge-based systems such as Hearsay II [3] was limited, the statistically based approach led to great improvements in recognition rates and to industrial applications.
  • Wittenburg, P., Drude, S., & Broeder, D. (2012). Psycholinguistik. In H. Neuroth, S. Strathmann, A. Oßwald, R. Scheffel, J. Klump, & J. Ludwig (Eds.), Langzeitarchivierung von Forschungsdaten. Eine Bestandsaufnahme (pp. 83-108). Boizenburg: Verlag Werner Hülsbusch.

    Abstract

    5.1 Einführung in den Forschungsbereich Die Psycholinguistik ist der Bereich der Linguistik, der sich mit dem Zusammenhang zwischen menschlicher Sprache und dem Denken und anderen mentalen Prozessen beschäftigt, d.h. sie stellt sich einer Reihe von essentiellen Fragen wie etwa (1) Wie schafft es unser Gehirn, im Wesentlichen akustische und visuelle kommunikative Informationen zu verstehen und in mentale Repräsentationen umzusetzen? (2) Wie kann unser Gehirn einen komplexen Sachverhalt, den wir anderen übermitteln wollen, in eine von anderen verarbeitbare Sequenz von verbalen und nonverbalen Aktionen umsetzen? (3) Wie gelingt es uns, in den verschiedenen Phasen des Lebens Sprachen zu erlernen? (4) Sind die kognitiven Prozesse der Sprachverarbeitung universell, obwohl die Sprachsysteme derart unterschiedlich sind, dass sich in den Strukturen kaum Universalien finden lassen?
  • Wnuk, E., & Majid, A. (2012). Olfaction in a hunter-gatherer society: Insights from language and culture. In N. Miyake, D. Peebles, & R. P. Cooper (Eds.), Proceedings of the 34th Annual Meeting of the Cognitive Science Society (CogSci 2012) (pp. 1155-1160). Austin, TX: Cognitive Science Society.

    Abstract

    According to a widely-held view among various scholars, olfaction is inferior to other human senses. It is also believed by many that languages do not have words for describing smells. Data collected among the Maniq, a small population of nomadic foragers in southern Thailand, challenge the above claims and point to a great linguistic and cultural elaboration of odor. This article presents evidence of the importance of olfaction in indigenous rituals and beliefs, as well as in the lexicon. The results demonstrate the richness and complexity of the domain of smell in Maniq society and thereby challenge the universal paucity of olfactory terms and insignificance of olfaction for humans.
  • Wohlgemuth, J., & Dirksmeyer, T. (Eds.). (2005). Bedrohte Vielfalt. Aspekte des Sprach(en)tods – Aspects of language death. Berlin: Weißensee.

    Abstract

    About 5,000 languages are spoken in the world today. More than half of them have less than 10,000 speakers, a quarter of them even fewer than 1,000. The majority of these “small” languages will not live to see the end of this century; some estimates predict that no more than a dozen languages will still be spoken by the turn of the next millennium. This collection of papers approaches the subject of language extinction through five major topics: general aspects of language death, case studies, endangered subsystems, language protection and revitalization, language ecology. In 24 articles, the authors address the causes, manifestations, and consequences of language endangerment and extinction as well as the linguistic and social changes associated with it, drawing examples from a large number of languages.
  • Li, Q., Wojciechowski, R., Simpson, C. L., Hysi, P. G., Verhoeven, V. J. M., Ikram, M. K., Höhn, R., Vitart, V., Hewitt, A. W., Oexle, K., Mäkelä, K.-M., MacGregor, S., Pirastu, M., Fan, Q., Cheng, C.-Y., St Pourcain, B., McMahon, G., Kemp, J. P., Northstone, K., Rahi, J. S. and 69 moreLi, Q., Wojciechowski, R., Simpson, C. L., Hysi, P. G., Verhoeven, V. J. M., Ikram, M. K., Höhn, R., Vitart, V., Hewitt, A. W., Oexle, K., Mäkelä, K.-M., MacGregor, S., Pirastu, M., Fan, Q., Cheng, C.-Y., St Pourcain, B., McMahon, G., Kemp, J. P., Northstone, K., Rahi, J. S., Cumberland, P. M., Martin, N. G., Sanfilippo, P. G., Lu, Y., Wang, Y. X., Hayward, C., Polašek, O., Campbell, H., Bencic, G., Wright, A. F., Wedenoja, J., Zeller, T., Schillert, A., Mirshahi, A., Lackner, K., Yip, S. P., Yap, M. K. H., Ried, J. S., Gieger, C., Murgia, F., Wilson, J. F., Fleck, B., Yazar, S., Vingerling, J. R., Hofman, A., Uitterlinden, A., Rivadeneira, F., Amin, N., Karssen, L., Oostra, B. A., Zhou, X., Teo, Y.-Y., Tai, E. S., Vithana, E., Barathi, V., Zheng, Y., Siantar, R. G., Neelam, K., Shin, Y., Lam, J., Yonova-Doing, E., Venturini, C., Hosseini, S. M., Wong, H.-S., Lehtimäki, T., Kähönen, M., Raitakari, O., Timpson, N. J., Evans, D. M., Khor, C.-C., Aung, T., Young, T. L., Mitchell, P., Klein, B., van Duijn, C. M., Meitinger, T., Jonas, J. B., Baird, P. N., Mackey, D. A., Wong, T. Y., Saw, S.-M., Pärssinen, O., Stambolian, D., Hammond, C. J., Klaver, C. C. W., Williams, C., Paterson, A. D., Bailey-Wilson, J. E., & Guggenheim, J. A. (2015). Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium. Human Genetics, 134, 131-146. doi:10.1007/s00439-014-1500-y.

    Abstract

    To identify genetic variants associated with refractive astigmatism in the general population, meta-analyses of genome-wide association studies were performed for: White Europeans aged at least 25 years (20 cohorts, N = 31,968); Asian subjects aged at least 25 years (7 cohorts, N = 9,295); White Europeans aged <25 years (4 cohorts, N = 5,640); and all independent individuals from the above three samples combined with a sample of Chinese subjects aged <25 years (N = 45,931). Participants were classified as cases with refractive astigmatism if the average cylinder power in their two eyes was at least 1.00 diopter and as controls otherwise. Genome-wide association analysis was carried out for each cohort separately using logistic regression. Meta-analysis was conducted using a fixed effects model. In the older European group the most strongly associated marker was downstream of the neurexin-1 (NRXN1) gene (rs1401327, P = 3.92E−8). No other region reached genome-wide significance, and association signals were lower for the younger European group and Asian group. In the meta-analysis of all cohorts, no marker reached genome-wide significance: The most strongly associated regions were, NRXN1 (rs1401327, P = 2.93E−07), TOX (rs7823467, P = 3.47E−07) and LINC00340 (rs12212674, P = 1.49E−06). For 34 markers identified in prior GWAS for spherical equivalent refractive error, the beta coefficients for genotype versus spherical equivalent, and genotype versus refractive astigmatism, were highly correlated (r = −0.59, P = 2.10E−04). This work revealed no consistent or strong genetic signals for refractive astigmatism; however, the TOX gene region previously identified in GWAS for spherical equivalent refractive error was the second most strongly associated region. Analysis of additional markers provided evidence supporting widespread genetic co-susceptibility for spherical and astigmatic refractive errors.
  • Wolf, M. C. (2015). Het verschil tussen hardop en stillezen wat betreft leessnelheid en tekstbegrip en de invloed hierop van fonologisch bewustzijn, benoemsnelheid en visuele aandachtsspanne. Student Undergraduate Research E-journal, 1(1), 261-264. Retrieved from http://journals.library.tudelft.nl/index.php/sure/article/view/1025.

    Abstract

    In het onderwijs wordt aangenomen dat hardop en stillezen dezelfde processen zijn. In dit onderzoek wordt gekeken naar het verschil tussen hardop en stillezen wat betreft leessnelheid en tekstbegrip bij 90 kinderen uit groep 4. Ook wordt de invloed van de cognitieve vaardigheden fonologisch bewustzijn, benoemsnelheid en visuele aandachtsspanne op de verschillende leesmodi onderzocht. De participanten lazen stil sneller, maar begrepen de tekst beter hardop. De cognitieve vaardigheden correleerden met hardop en stillezen wat betreft leessnelheid, maar hingen in beide leesmodi niet samen met tekstbegrip. Hoewel hardop en stillezen samenhangen, onderstrepen deze bevindingen dat het verschillende leesmodi zijn.
  • Won, S.-O., Hu, I., Kim, M.-Y., Bae, J.-M., Kim, Y.-M., & Byun, K.-S. (2009). Theory and practice of Sign Language interpretation. Pyeongtaek: Korea National College of Rehabilitation & Welfare.
  • Wood, N. (2009). Field recording for dummies. In A. Majid (Ed.), Field manual volume 12 (pp. V). Nijmegen: Max Planck Institute for Psycholinguistics.
  • Xiang, H., Van Leeuwen, T. M., Dediu, D., Roberts, L., Norris, D. G., & Hagoort, P. (2015). L2-proficiency-dependent laterality shift in structural connectivity of brain language pathways. Brain Connectivity, 5(6), 349-361. doi:10.1089/brain.2013.0199.

    Abstract

    Diffusion tensor imaging (DTI) and a longitudinal language learning approach were applied to investigate the relationship between the achieved second language (L2) proficiency during L2 learning and the reorganization of structural connectivity between core language areas. Language proficiency tests and DTI scans were obtained from German students before and after they completed an intensive 6-week course of the Dutch language. In the initial learning stage, with increasing L2 proficiency, the hemispheric dominance of the BA6-temporal pathway (mainly along the arcuate fasciculus) shifted from the left to the right hemisphere. With further increased proficiency, however, lateralization dominance was again found in the left BA6-temporal pathway. This result is consistent with reports in the literature that imply a stronger involvement of the right hemisphere in L2-processing especially for less proficient L2-speakers. This is the first time that a L2-proficiency-dependent laterality shift in structural connectivity of language pathways during L2 acquisition has been observed to shift from left to right, and back to left hemisphere dominance with increasing L2-proficiency. We additionally find that changes in fractional anisotropy values after the course are related to the time elapsed between the two scans. The results suggest that structural connectivity in (at least part of) the perisylvian language network may be subject to fast dynamic changes following language learning
  • Xiang, H., Dediu, D., Roberts, L., Van Oort, E., Norris, D., & Hagoort, P. (2012). The structural connectivity underpinning language aptitude, working memory and IQ in the perisylvian language network. Language Learning, 62(Supplement S2), 110-130. doi:10.1111/j.1467-9922.2012.00708.x.

    Abstract

    We carried out the first study on the relationship between individual language aptitude and structural connectivity of language pathways in the adult brain. We measured four components of language aptitude (vocabulary learning, VocL; sound recognition, SndRec; sound-symbol correspondence, SndSym; and grammatical inferencing, GrInf) using the LLAMA language aptitude test (Meara, 2005). Spatial working memory (SWM), verbal working memory (VWM) and IQ were also measured as control factors. Diffusion Tensor Imaging (DTI) was employed to investigate the structural connectivity of language pathways in the perisylvian language network. Principal Component Analysis (PCA) on behavioural measures suggests that a general ability might be important to the first stages of L2 acquisition. It also suggested that VocL, SndSy and SWM are more closely related to general IQ than SndRec and VocL, and distinguished the tasks specifically designed to tap into L2 acquisition (VocL, SndRec,SndSym and GrInf) from more generic measures (IQ, SWM and VWM). Regression analysis suggested significant correlations between most of these behavioural measures and the structural connectivity of certain language pathways, i.e., VocL and BA47-Parietal pathway, SndSym and inter-hemispheric BA45 pathway, GrInf and BA45-Temporal pathway and BA6-Temporal pathway, IQ and BA44-Parietal pathway, BA47-Parietal pathway, BA47-Temporal pathway and inter-hemispheric BA45 pathway, SWM and inter-hemispheric BA6 pathway and BA47-Parietal pathway, and VWM and BA47-Temporal pathway. These results are discussed in relation to relevant findings in the literature.
  • Xiang, H. (2012). The language networks of the brain. PhD Thesis, Radboud University Nijmegen, Nijmegen.

    Abstract

    In recent decades, neuroimaging studies on the neural infrastructure of language are usually (or mostly) conducted with certain on-line language processing tasks. These functional neuroimaging studies helped to localize the language areas in the brain and to investigate the brain activity during explicit language processing. However, little is known about what is going on with the language areas when the brain is ‘at rest’, i.e., when there is no explicit language processing running. Taking advantage of the fcMRI and DTI techniques, this thesis is able to investigate the language function ‘off-line’ at the neuronal network level and the connectivity among language areas in the brain. Based on patient studies, the traditional, classical model on the perisylvian language network specifies a “Broca’ area – Arcuate Fasciculus – Werinicke’s area” loop (Ojemann 1991). With the help of modern neuroimaging techniques, researchers have been able to track language pathways that involve more brain structures than are in the classical model, and relate them to certain language functions. In such a background, a large part of this thesis made a contribution to the study of the topology of the language networks. It revealed that the language networks form a topographical functional connectivity pattern in the left hemisphere for the right-handers. This thesis also revealed the importance of structural hubs, such as Broca’s and Wernicke’s areas, which have more connectivity to other brain areas and play a central role in the language networks. Furthermore, this thesis revealed both functionally and structurally lateralized language networks in the brain. The consistency between what is found in this thesis and what has been known from previous functional studies seems to suggest, that the human brain is optimized and ‘ready’ for the language function even when there is currently no explicit language-processing running.
  • Xiao, M., Kong, X., Liu, J., & Ning, J. (2009). TMBF: Bloom filter algorithms of time-dependent multi bit-strings for incremental set. In Proceedings of the 2009 International Conference on Ultra Modern Telecommunications & Workshops.

    Abstract

    Set is widely used as a kind of basic data structure. However, when it is used for large scale data set the cost of storage, search and transport is overhead. The bloom filter uses a fixed size bit string to represent elements in a static set, which can reduce storage space and search cost that is a fixed constant. The time-space efficiency is achieved at the cost of a small probability of false positive in membership query. However, for many applications the space savings and locating time constantly outweigh this drawback. Dynamic bloom filter (DBF) can support concisely representation and approximate membership queries of dynamic set instead of static set. It has been proved that DBF not only possess the advantage of standard bloom filter, but also has better features when dealing with dynamic set. This paper proposes a time-dependent multiple bit-strings bloom filter (TMBF) which roots in the DBF and targets on dynamic incremental set. TMBF uses multiple bit-strings in time order to present a dynamic increasing set and uses backward searching to test whether an element is in a set. Based on the system logs from a real P2P file sharing system, the evaluation shows a 20% reduction in searching cost compared to DBF.
  • You, W., Zhang, Q., & Verdonschot, R. G. (2012). Masked syllable priming effects in word and picture naming in Chinese. PLoS One, 7(10): e46595. doi:10.1371/journal.pone.0046595.

    Abstract

    Four experiments investigated the role of the syllable in Chinese spoken word production. Chen, Chen and Ferrand (2003) reported a syllable priming effect when primes and targets shared the first syllable using a masked priming paradigm in Chinese. Our Experiment 1 was a direct replication of Chen et al.'s (2003) Experiment 3 employing CV (e. g., /ba2.ying2/, strike camp) and CVG (e. g., /bai2.shou3/, white haired) syllable types. Experiment 2 tested the syllable priming effect using different syllable types: e. g., CV (/qi4.qiu2/, balloon) and CVN (/qing1.ting2/, dragonfly). Experiment 3 investigated this issue further using line drawings of common objects as targets that were preceded either by a CV (e. g., /qi3/, attempt), or a CVN (e. g., /qing2/, affection) prime. Experiment 4 further examined the priming effect by a comparison between CV or CVN priming and an unrelated priming condition using CV-NX (e. g., /mi2.ni3/, mini) and CVN-CX (e. g., /min2.ju1/, dwellings) as target words. These four experiments consistently found that CV targets were named faster when preceded by CV primes than when they were preceded by CVG, CVN or unrelated primes, whereas CVG or CVN targets showed the reverse pattern. These results indicate that the priming effect critically depends on the match between the structure of the prime and that of the first syllable of the target. The effect obtained in this study was consistent across different stimuli and different tasks (word and picture naming), and provides more conclusive and consistent data regarding the role of the syllable in Chinese speech production.
  • Zampieri, M., & Gebre, B. G. (2012). Automatic identification of language varieties: The case of Portuguese. In J. Jancsary (Ed.), Proceedings of the Conference on Natural Language Processing 2012, September 19-21, 2012, Vienna (pp. 233-237). Vienna: Österreichischen Gesellschaft für Artificial Intelligende (ÖGAI).

    Abstract

    Automatic Language Identification of written texts is a well-established area of research in Computational Linguistics. State-of-the-art algorithms often rely on n-gram character models to identify the correct language of texts, with good results seen for European languages. In this paper we propose the use of a character n-gram model and a word n-gram language model for the automatic classification of two written varieties of Portuguese: European and Brazilian. Results reached 0.998 for accuracy using character 4-grams.
  • Zampieri, M., Gebre, B. G., & Diwersy, S. (2012). Classifying pluricentric languages: Extending the monolingual model. In Proceedings of SLTC 2012. The Fourth Swedish Language Technology Conference. Lund, October 24-26, 2012 (pp. 79-80). Lund University.

    Abstract

    This study presents a new language identification model for pluricentric languages that uses n-gram language models at the character and word level. The model is evaluated in two steps. The first step consists of the identification of two varieties of Spanish (Argentina and Spain) and two varieties of French (Quebec and France) evaluated independently in binary classification schemes. The second step integrates these language models in a six-class classification with two Portuguese varieties.
  • Zeshan, U. (2005). Sign languages. In M. Haspelmath, M. S. Dryer, D. Gil, & B. Comrie (Eds.), The world atlas of language structures (pp. 558-559). Oxford: Oxford University Press.
  • Zeshan, U. (2005). Question particles in sign languages. In M. Haspelmath, M. S. Dryer, D. Gil, & B. Comrie (Eds.), The world atlas of language structures (pp. 564-567). Oxford: Oxford University Press.
  • Zeshan, U., & Panda, S. (2005). Professional course in Indian sign language. Mumbai: Ali Yavar Jung National Institute for the Hearing Handicapped.
  • Zeshan, U., Pfau, R., & Aboh, E. (2005). When a wh-word is not a wh-word: the case of Indian sign language. In B. Tanmoy (Ed.), Yearbook of South Asian languages and linguistics 2005 (pp. 11-43). Berlin: Mouton de Gruyter.
  • Zeshan, U. (2003). Aspects of Türk Işaret Dili (Turkish Sign Language). Sign Language and Linguistics, 6(1), 43-75. doi:10.1075/sll.6.1.04zes.

    Abstract

    This article provides a first overview of some striking grammatical structures in Türk Idotscedilaret Dili (Turkish Sign Language, TID), the sign language used by the Deaf community in Turkey. The data are described with a typological perspective in mind, focusing on aspects of TID grammar that are typologically unusual across sign languages. After giving an overview of the historical, sociolinguistic and educational background of TID and the language community using this sign language, five domains of TID grammar are investigated in detail. These include a movement derivation signalling completive aspect, three types of nonmanual negation — headshake, backward head tilt, and puffed cheeks — and their distribution, cliticization of the negator NOT to a preceding predicate host sign, an honorific whole-entity classifier used to refer to humans, and a question particle, its history and current status in the language. A final evaluation points out the significance of these data for sign language research and looks at perspectives for a deeper understanding of the language and its history.
  • Zeshan, U., Vasishta, M. N., & Sethna, M. (2005). Implementation of Indian Sign Language in educational settings. Asia Pacific Disability Rehabilitation Journal, 16(1), 16-40.

    Abstract

    This article reports on several sub-projects of research and development related to the use of Indian Sign Language in educational settings. In many countries around the world, sign languages are now recognised as the legitimate, full-fledged languages of the deaf communities that use them. In India, the development of sign language resources and their application in educational contexts, is still in its initial stages. The work reported on here, is the first principled and comprehensive effort of establishing educational programmes in Indian Sign Language at a national level. Programmes are of several types: a) Indian Sign Language instruction for hearing people; b) sign language teacher training programmes for deaf people; and c) educational materials for use in schools for the Deaf. The conceptual approach used in the programmes for deaf students is known as bilingual education, which emphasises the acquisition of a first language, Indian Sign Language, alongside the acquisition of spoken languages, primarily in their written form.
  • Zeshan, U. (2005). Irregular negatives in sign languages. In M. Haspelmath, M. S. Dryer, D. Gil, & B. Comrie (Eds.), The world atlas of language structures (pp. 560-563). Oxford: Oxford University Press.
  • Zeshan, U., & De Vos, C. (Eds.). (2012). Sign languages in village communities: Anthropological and linguistic insights. Berlin: Mouton de Gruyter.

    Abstract

    The book is a unique collection of research on sign languages that have emerged in rural communities with a high incidence of, often hereditary, deafness. These sign languages represent the latest addition to the comparative investigation of languages in the gestural modality, and the book is the first compilation of a substantial number of different "village sign languages".Written by leading experts in the field, the volume uniquely combines anthropological and linguistic insights, looking at both the social dynamics and the linguistic structures in these village communities. The book includes primary data from eleven different signing communities across the world, including results from Jamaica, India, Turkey, Thailand, and Bali. All known village sign languages are endangered, usually because of pressure from larger urban sign languages, and some have died out already. Ironically, it is often the success of the larger sign language communities in urban centres, their recognition and subsequent spread, which leads to the endangerment of these small minority sign languages. The book addresses this specific type of language endangerment, documentation strategies, and other ethical issues pertaining to these sign languages on the basis of first-hand experiences by Deaf fieldworkers
  • Zhang, Y., Yurovsky, D., & Yu, C. (2015). Statistical word learning is a continuous process: Evidence from the human simulation paradigm. In D. Noelle, R. Dale, A. Warlaumont, J. Yoshimi, T. Matlock, C. D. Jennings, & P. P. Maglio (Eds.), Proceedings of the 37th Annual Meeting of the Cognitive Science Society (CogSci 2015) (pp. 2422-2427). Austin: Cognitive Science Society.

    Abstract

    In the word-learning domain, both adults and young children are able to find the correct referent of a word from highly ambiguous contexts that involve many words and objects by computing distributional statistics across the co-occurrences of words and referents at multiple naming moments (Yu & Smith, 2007; Smith & Yu, 2008). However, there is still debate regarding how learners accumulate distributional information to learn object labels in natural learning environments, and what underlying learning mechanism learners are most likely to adopt. Using the Human Simulation Paradigm (Gillette, Gleitman, Gleitman & Lederer, 1999), we found that participants’ learning performance gradually improved and that their ability to remember and carry over partial knowledge from past learning instances facilitated subsequent learning. These results support the statistical learning model that word learning is a continuous process.
  • Zhang, J., Bao, S., Furumai, R., Kucera, K. S., Ali, A., Dean, N. M., & Wang, X.-F. (2005). Protein phosphatase 5 is required for ATR-mediated checkpoint activation. Molecular and Cellular Biology, 25, 9910-9919. doi:10.1128/​MCB.25.22.9910-9919.2005.

    Abstract

    In response to DNA damage or replication stress, the protein kinase ATR is activated and subsequently transduces genotoxic signals to cell cycle control and DNA repair machinery through phosphorylation of a number of downstream substrates. Very little is known about the molecular mechanism by which ATR is activated in response to genotoxic insults. In this report, we demonstrate that protein phosphatase 5 (PP5) is required for the ATR-mediated checkpoint activation. PP5 forms a complex with ATR in a genotoxic stress-inducible manner. Interference with the expression or the activity of PP5 leads to impairment of the ATR-mediated phosphorylation of hRad17 and Chk1 after UV or hydroxyurea treatment. Similar results are obtained in ATM-deficient cells, suggesting that the observed defect in checkpoint signaling is the consequence of impaired functional interaction between ATR and PP5. In cells exposed to UV irradiation, PP5 is required to elicit an appropriate S-phase checkpoint response. In addition, loss of PP5 leads to premature mitosis after hydroxyurea treatment. Interestingly, reduced PP5 activity exerts differential effects on the formation of intranuclear foci by ATR and replication protein A, implicating a functional role for PP5 in a specific stage of the checkpoint signaling pathway. Taken together, our results suggest that PP5 plays a critical role in the ATR-mediated checkpoint activation.
  • Zhao, H., Zhou, W., Yao, Z., Wan, Y., Cao, J., Zhang, L., Zhao, J., Li, H., Zhou, R., Li, B., Wei, G., Zhang, Z., French, C. A., Dekker, J. D., Yang, Y., Fisher, S. E., Tucker, H. O., & Guo, X. (2015). Foxp1/2/4 regulate endochondral ossification as a suppresser complex. Developmental Biology, 398, 242-254. doi:10.1016/j.ydbio.2014.12.007.

    Abstract

    Osteoblast induction and differentiation in developing long bones is dynamically controlled by the opposing action of transcriptional activators and repressors. In contrast to the long list of activators that have been discovered over past decades, the network of repressors is not well-defined. Here we identify the expression of Foxp1/2/4 proteins, comprised of Forkhead-box (Fox) transcription factors of the Foxp subfamily, in both perichondrial skeletal progenitors and proliferating chondrocytes during endochondral ossification. Mice carrying loss-of-function and gain-of-function Foxp mutations had gross defects in appendicular skeleton formation. At the cellular level, over-expression of Foxp1/2/4 in chondroctyes abrogated osteoblast formation and chondrocyte hypertrophy. Conversely, single or compound deficiency of Foxp1/2/4 in skeletal progenitors or chondrocytes resulted in premature osteoblast differentiation in the perichondrium, coupled with impaired proliferation, survival, and hypertrophy of chondrocytes in the growth plate. Foxp1/2/4 and Runx2 proteins interacted in vitro and in vivo, and Foxp1/2/4 repressed Runx2 transactivation function in heterologous cells. This study establishes Foxp1/2/4 proteins as coordinators of osteogenesis and chondrocyte hypertrophy in developing long bones and suggests that a novel transcriptional repressor network involving Foxp1/2/4 may regulate Runx2 during endochondral ossification.
  • Zhen, Z., Yang, Z., Huang, L., Kong, X., Wang, X., Dang, X., Huang, Y., Song, Y., & Liu, J. (2015). Quantifying interindividual variability and asymmetry of face-selective regions: A probabilistic functional atlas. NeuroImage, 113, 13-25. doi:10.1016/j.neuroimage.2015.03.010.

    Abstract

    Face-selective regions (FSRs) are among the most widely studied functional regions in the human brain. However, individual variability of the FSRs has not been well quantified. Here we use functional magnetic resonance imaging (fMRI) to localize the FSRs and quantify their spatial and functional variabilities in 202 healthy adults. The occipital face area (OFA), posterior and anterior fusiform face areas (pFFA and aFFA), posterior continuation of the superior temporal sulcus (pcSTS), and posterior and anterior STS (pSTS and aSTS) were delineated for each individual with a semi-automated procedure. A probabilistic atlas was constructed to characterize their interindividual variability, revealing that the FSRs were highly variable in location and extent across subjects. The variability of FSRs was further quantified on both functional (i.e., face selectivity) and spatial (i.e., volume, location of peak activation, and anatomical location) features. Considerable interindividual variability and rightward asymmetry were found in all FSRs on these features. Taken together, our work presents the first effort to characterize comprehensively the variability of FSRs in a large sample of healthy subjects, and invites future work on the origin of the variability and its relation to individual differences in behavioral performance. Moreover, the probabilistic functional atlas will provide an adequate spatial reference for mapping the face network.
  • Zhou, W. (2015). Assessing birth language memory in young adoptees. PhD Thesis, Radboud University Nijmegen, Nijmegen.
  • Zhu, Z., Hagoort, P., Zhang, J. X., Feng, G., Chen, H.-C., Bastiaansen, M. C. M., & Wang, S. (2012). The anterior left inferior frontal gyrus contributes to semantic unification. NeuroImage, 60, 2230-2237. doi:10.1016/j.neuroimage.2012.02.036.

    Abstract

    Semantic unification, the process by which small blocks of semantic information are combined into a coherent utterance, has been studied with various types of tasks. However, whether the brain activations reported in these studies are attributed to semantic unification per se or to other task-induced concomitant processes still remains unclear. The neural basis for semantic unification in sentence comprehension was examined using event-related potentials (ERP) and functional Magnetic Resonance Imaging (fMRI). The semantic unification load was manipulated by varying the goodness of fit between a critical word and its preceding context (in high cloze, low cloze and violation sentences). The sentences were presented in a serial visual presentation mode. The participants were asked to perform one of three tasks: semantic congruency judgment (SEM), silent reading for comprehension (READ), or font size judgment (FONT), in separate sessions. The ERP results showed a similar N400 amplitude modulation by the semantic unification load across all of the three tasks. The brain activations associated with the semantic unification load were found in the anterior left inferior frontal gyrus (aLIFG) in the FONT task and in a widespread set of regions in the other two tasks. These results suggest that the aLIFG activation reflects a semantic unification, which is different from other brain activations that may reflect task-specific strategic processing.

    Additional information

    Zhu_2012_suppl.dot
  • Zora, H., Schwarz, I.-C., & Heldner, M. (2015). Neural correlates of lexical stress: Mismatch negativity reflects fundamental frequency and intensity. NeuroReport, 26(13), 791-796. doi:10.1097/WNR.0000000000000426.

    Abstract

    Neural correlates of lexical stress were studied using the mismatch negativity (MMN) component in event-related potentials. The MMN responses were expected to reveal the encoding of stress information into long-term memory and the contributions of prosodic features such as fundamental frequency (F0) and intensity toward lexical access. In a passive oddball paradigm, neural responses to changes in F0, intensity, and in both features together were recorded for words and pseudowords. The findings showed significant differences not only between words and pseudowords but also between prosodic features. Early processing of prosodic information in words was indexed by an intensity-related MMN and an F0-related P200. These effects were stable at right-anterior and mid-anterior regions. At a later latency, MMN responses were recorded for both words and pseudowords at the mid-anterior and posterior regions. The P200 effect observed for F0 at the early latency for words developed into an MMN response. Intensity elicited smaller MMN for pseudowords than for words. Moreover, a larger brain area was recruited for the processing of words than for the processing of pseudowords. These findings suggest earlier and higher sensitivity to prosodic changes in words than in pseudowords, reflecting a language-related process. The present study, therefore, not only establishes neural correlates of lexical stress but also confirms the presence of long-term memory traces for prosodic information in the brain.
  • Zwaan, R. A., Van der Stoep, N., Guadalupe, T., & Bouwmeester, S. (2012). Language comprehension in the balance: The robustness of the action-compatibility effect (ACE). PLoS One, 7(2), e31204. doi:10.1371/journal.pone.0031204.

    Abstract

    How does language comprehension interact with motor activity? We investigated the conditions under which comprehending an action sentence affects people's balance. We performed two experiments to assess whether sentences describing forward or backward movement modulate the lateral movements made by subjects who made sensibility judgments about the sentences. In one experiment subjects were standing on a balance board and in the other they were seated on a balance board that was mounted on a chair. This allowed us to investigate whether the action compatibility effect (ACE) is robust and persists in the face of salient incompatibilities between sentence content and subject movement. Growth-curve analysis of the movement trajectories produced by the subjects in response to the sentences suggests that the ACE is indeed robust. Sentence content influenced movement trajectory despite salient inconsistencies between implied and actual movement. These results are interpreted in the context of the current discussion of embodied, or grounded, language comprehension and meaning representation.
  • Zwitserlood, I. (2012). Classifiers. In R. Pfau, M. Steinbach, & B. Woll (Eds.), Sign Language: an International Handbook (pp. 158-186). Berlin: Mouton de Gruyter.

    Abstract

    Classifiers (currently also called 'depicting handshapes'), are observed in almost all signed languages studied to date and form a well-researched topic in sign language linguistics. Yet, these elements are still subject to much debate with respect to a variety of matters. Several different categories of classifiers have been posited on the basis of their semantics and the linguistic context in which they occur. The function(s) of classifiers are not fully clear yet. Similarly, there are differing opinions regarding their structure and the structure of the signs in which they appear. Partly as a result of comparison to classifiers in spoken languages, the term 'classifier' itself is under debate. In contrast to these disagreements, most studies on the acquisition of classifier constructions seem to consent that these are difficult to master for Deaf children. This article presents and discusses all these issues from the viewpoint that classifiers are linguistic elements.
  • Zwitserlood, I. (2003). Classifying hand configurations in Nederlandse Gebarentaal (Sign Language of the Netherlands). PhD Thesis, LOT, Utrecht. Retrieved from http://igitur-archive.library.uu.nl/dissertations/2003-0717-122837/UUindex.html.

    Abstract

    This study investigates the morphological and morphosyntactic characteristics of hand configurations in signs, particularly in Nederlandse Gebarentaal (NGT). The literature on sign languages in general acknowledges that hand configurations can function as morphemes, more specifically as classifiers , in a subset of signs: verbs expressing the motion, location, and existence of referents (VELMs). These verbs are considered the output of productive sign formation processes. In contrast, other signs in which similar hand configurations appear ( iconic or motivated signs) have been considered to be lexicalized signs, not involving productive processes. This research report shows that meaningful hand configurations have (at least) two very different functions in the grammar of NGT (and presumably in other sign languages, too). First, they are agreement markers on VELMs, and hence are functional elements. Second, they are roots in motivated signs, and thus lexical elements. The latter signs are analysed as root compounds and are formed from various roots by productive processes. The similarities in surface form and differences in morphosyntactic characteristics observed in comparison of VELMs and root compounds are attributed to their different structures and to the sign language interface between grammar and phonetic form
  • Zwitserlood, I., Perniss, P. M., & Ozyurek, A. (2012). An empirical investigation of expression of multiple entities in Turkish Sign Language (TİD): Considering the effects of modality. Lingua, 122, 1636 -1667. doi:10.1016/j.lingua.2012.08.010.

    Abstract

    This paper explores the expression of multiple entities in Turkish Sign Language (Türk İşaret Dili; TİD), a less well-studied sign language. It aims to provide a comprehensive description of the ways and frequencies in which entity plurality in this language is expressed, both within and outside the noun phrase. We used a corpus that includes both elicited and spontaneous data from native signers. The results reveal that most of the expressions of multiple entities in TİD are iconic, spatial strategies (i.e. localization and spatial plural predicate inflection) none of which, we argue, should be considered as genuine plural marking devices with the main aim of expressing plurality. Instead, the observed devices for localization and predicate inflection allow for a plural interpretation when multiple locations in space are used. Our data do not provide evidence that TİD employs (productive) morphological plural marking (i.e. reduplication) on nouns, in contrast to some other sign languages and many spoken languages. We relate our findings to expression of multiple entities in other signed languages and in spoken languages and discuss these findings in terms of modality effects on expression of multiple entities in human language.
  • Zwitserlood, P. (1990). Max-Planck-Institute for Psycholinguistics: Annual Report Nr.11 1990. Nijmegen: MPI for Psycholinguistics.
  • Zwitserlood, I. (2009). Het Corpus NGT. Levende Talen Magazine, 6, 44-45.

    Abstract

    The Corpus NGT
  • Zwitserlood, I. (2009). Het Corpus NGT en de dagelijkse lespraktijk (1). Levende Talen Magazine, 8, 40-41.
  • Zwitserlood, I. (2003). Word formation below and above little x: Evidence from Sign Language of the Netherlands. In Proceedings of SCL 19. Nordlyd Tromsø University Working Papers on Language and Linguistics (pp. 488-502).

    Abstract

    Although in many respects sign languages have a similar structure to that of spoken languages, the different modalities in which both types of languages are expressed cause differences in structure as well. One of the most striking differences between spoken and sign languages is the influence of the interface between grammar and PF on the surface form of utterances. Spoken language words and phrases are in general characterized by sequential strings of sounds, morphemes and words, while in sign languages we find that many phonemes, morphemes, and even words are expressed simultaneously. A linguistic model should be able to account for the structures that occur in both spoken and sign languages. In this paper, I will discuss the morphological/ morphosyntactic structure of signs in Nederlandse Gebarentaal (Sign Language of the Netherlands, henceforth NGT), with special focus on the components ‘place of articulation’ and ‘handshape’. I will focus on their multiple functions in the grammar of NGT and argue that the framework of Distributed Morphology (DM), which accounts for word formation in spoken languages, is also suited to account for the formation of structures in sign languages. First I will introduce the phonological and morphological structure of NGT signs. Then, I will briefly outline the major characteristics of the DM framework. Finally, I will account for signs that have the same surface form but have a different morphological structure by means of that framework.

Share this page