Publications

Displaying 201 - 300 of 635
  • Hagoort, P., & Brown, C. M. (2000). ERP effects of listening to speech compared to reading: the P600/SPS to syntactic violations in spoken sentences and rapid serial visual presentation. Neuropsychologia, 38, 1531-1549.

    Abstract

    In this study, event-related brain potential ffects of speech processing are obtained and compared to similar effects in sentence reading. In two experiments sentences were presented that contained three different types of grammatical violations. In one experiment sentences were presented word by word at a rate of four words per second. The grammatical violations elicited a Syntactic Positive Shift (P600/SPS), 500 ms after the onset of the word that rendered the sentence ungrammatical. The P600/SPS consisted of two phases, an early phase with a relatively equal anterior-posterior distribution and a later phase with a strong posterior distribution. We interpret the first phase as an indication of structural integration complexity, and the second phase as an indication of failing parsing operations and/or an attempt at reanalysis. In the second experiment the same syntactic violations were presented in sentences spoken at a normal rate and with normal intonation. These violations elicited a P600/SPS with the same onset as was observed for the reading of these sentences. In addition two of the three violations showed a preceding frontal negativity, most clearly over the left hemisphere.
  • Hagoort, P., & Brown, C. M. (2000). ERP effects of listening to speech: semantic ERP effects. Neuropsychologia, 38, 1518-1530.

    Abstract

    In this study, event-related brain potential effects of speech processing are obtained and compared to similar effects insentence reading. In two experiments spoken sentences were presented with semantic violations in sentence-signal or mid-sentence positions. For these violations N400 effects were obtained that were very similar to N400 effects obtained in reading. However, the N400 effects in speech were preceded by an earlier negativity (N250). This negativity is not commonly observed with written input. The early effect is explained as a manifestation of a mismatch between the word forms expected on the basis of the context, and the actual cohort of activated word candidates that is generated on the basis of the speech signal.
  • Hagoort, P. (2005). De talige aap. Linguaan, 26-35.
  • Hagoort, P. (2005). Breintaal. In S. Knols, & D. Redeker (Eds.), NWO-Spinozapremies 2005 (pp. 21-34). Den Haag: NWO.
  • Hagoort, P. (2005). Broca's complex as the unification space for language. In A. Cutler (Ed.), Twenty-first century psycholinguistics: Four cornerstones (pp. 157-173). Mahwah, NJ: Erlbaum.
  • Hagoort, P., Brown, C. M., & Swaab, T. Y. (1996). Lexical-semantic event-related potential effects in patients with left hemisphere lesions and aphasia, and patients with right hemisphere lesions without aphasia. Brain, 119, 627-649. doi:10.1093/brain/119.2.627.

    Abstract

    Lexical-semantic processing impairments in aphasic patients with left hemisphere lesions and non-aphasic patients with right hemisphere lesions were investigated by recording event-related brain potentials (ERPs) while subjects listened to auditorily presented word pairs. The word pairs consisted of unrelated words, or words that were related in meaning. The related words were either associatively related, e.g. 'bread-butter', or were members of the same semantic category without being associatively related, e.g. 'churchvilla '. The latter relationships are assumed to be more distant than the former ones. The most relevant ERP component in this study is the N400. In elderly control subjects, the N400 amplitude to associatively and semantically related word targets is reduced relative to the N400 elicited by unrelated targets. Compared with this normal N400 effect, the different patient groups showed the following pattern of results: aphasic patients with only minor comprehension deficits (high comprehenders) showed N400 effects of a similar size as the control subjects. In aphasic patients with more severe comprehension deficits (low comprehenders) a clear reduction in the N400 effects was obtained, both for the associative and the semantic word pairs. The patients with right hemisphere lesions showed a normal N400 effect for the associatively related targets, but a trend towards a reduced N400 effect for the semantically related word pairs. A dissociation between the N400 results in the word pair paradigm and P300 results in a classical tone oddball task indicated that the N400 effects were not an aspecific consequence of brain lesion, but were related to the nature of the language comprehension impairment. The conclusions drawn from the ERP results are that comprehension deficits in the aphasic patients are due to an impairment in integrating individual word meanings into an overall meaning representation. Right hemisphere patients are more specifically impaired in the processing of semantically more distant relationships, suggesting the involvement of the right hemisphere in semantically coarse coding.
  • Hagoort, P. (1989). Processing of lexical ambiguities: a comment on Milberg, Blumstein, and Dworetzky (1987). Brain and Language, 36, 335-348. doi:10.1016/0093-934X(89)90070-9.

    Abstract

    In a study by Milberg, Blumstein, and Dworetzky (1987), normal control subjects and Wernicke's and Broca's aphasics performed a lexical decision task on the third element of auditorily presented triplets of words with either a word or a nonword as target. In three of the four types of word triplets, the first and the third words were related to one or both meanings of the second word, which was semantically ambiguous. The fourth type of word triplet consisted of three unrelated, unambiguous words, functioning as baseline. Milberg et al. (1987) claim that the results for their control subjects are similar to those reported by Schvaneveldt, Meyer, and Becker's original study (1976) with the same prime types, and so interpret these as evidence for a selective lexical access of the different meanings of ambiguous words. It is argued here that Milberg et al. only partially replicate the Schvaneveldt et al. results. Moreover, the results of Milberg et al. are not fully in line with the selective access hypothesis adopted. Replication of the Milberg et al. (1987) study with Dutch materials, using both a design without and a design with repetition of the same target words for the same subjects led to the original pattern as reported by Schvaneveldt et al. (1976). In the design with four separate presentations of the same target word, a strong repetition effect was found. It is therefore argued that the discrepancy between the Milberg et al. results on the one hand, and the Schvaneveldt et al. results on the other, might be due to the absence of a control for repetition effects in the within-subject design used by Milberg et al. It is concluded that this makes the results for both normal and aphasic subjects in the latter study difficult to interpret in terms of a selective access model for normal processing.
  • Hagoort, P., & Van Turennout, M. (1997). The electrophysiology of speaking: Possibilities of event-related potential research for speech production. In W. Hulstijn, H. Peters, & P. Van Lieshout (Eds.), Speech motor production and fluency disorders: Brain research in speech production (pp. 351-361). Amsterdam: Elsevier.
  • Hagoort, P. (1997). Semantic priming in Broca's aphasics at a short SOA: No support for an automatic access deficit. Brain and Language, 56, 287-300. doi:10.1006/brln.1997.1849.

    Abstract

    This study tests the recent claim that Broca’s aphasics are impaired in automatic lexical access, including the retrieval of word meaning. Subjects are required to perform a lexical decision on visually presented prime target pairs. Half of the word targets are preceded by a related word, half by an unrelated word. Primes and targets are presented with a long stimulus-onset-asynchrony (SOA) of 1400 msec and with a short SOA of 300 msec. Normal priming effects are observed in Broca’s aphasics for both SOAs. This result is discussed in the context of the claim that Broca’s aphasics suffer from an impairment in the automatic access of lexical–semantic information. It is argued that none of the current priming studies provides evidence supporting this claim, since with short SOAs priming effects have been reliably obtained in Broca’s aphasics. The results are more compatible with the claim that in many Broca’s aphasics the functional locus of their comprehension deficit is at the level of postlexical integration processes.
  • Hagoort, P., & Wassenaar, M. (1997). Taalstoornissen: Van theorie tot therapie. In B. Deelman, P. Eling, E. De Haan, A. Jennekens, & A. Van Zomeren (Eds.), Klinische Neuropsychologie (pp. 232-248). Meppel: Boom.
  • Hagoort, P. (2000). What we shall know only tomorrow. Brain and Language, 71, 89-92. doi:10.1006/brln.1999.2221.
  • Hagoort, P. (1997). Zonder fosfor geen gedachten: Gagarin, geest en brein. In Brain & Mind (pp. 6-14). Utrecht: Reünistenvereniging Veritas.
  • Hagoort, P. (1997). Valt er nog te lachen zonder de rechter hersenhelft? Psychologie, 16, 52-55.
  • Harbusch, K., & Kempen, G. (2000). Complexity of linear order computation in Performance Grammar, TAG and HPSG. In Proceedings of Fifth International Workshop on Tree Adjoining Grammars and Related Formalisms (TAG+5) (pp. 101-106).

    Abstract

    This paper investigates the time and space complexity of word order computation in the psycholinguistically motivated grammar formalism of Performance Grammar (PG). In PG, the first stage of syntax assembly yields an unordered tree ('mobile') consisting of a hierarchy of lexical frames (lexically anchored elementary trees). Associated with each lexica l frame is a linearizer—a Finite-State Automaton that locally computes the left-to-right order of the branches of the frame. Linearization takes place after the promotion component may have raised certain constituents (e.g. Wh- or focused phrases) into the domain of lexical frames higher up in the syntactic mobile. We show that the worst-case time and space complexity of analyzing input strings of length n is O(n5) and O(n4), respectively. This result compares favorably with the time complexity of word-order computations in Tree Adjoining Grammar (TAG). A comparison with Head-Driven Phrase Structure Grammar (HPSG) reveals that PG yields a more declarative linearization method, provided that the FSA is rewritten as an equivalent regular expression.
  • Haun, D. B. M., Allen, G. L., & Wedell, D. H. (2005). Bias in spatial memory: A categorical endorsement. Acta Psychologica, 118(1-2), 149-170. doi:10.1016/j.actpsy.2004.10.011.
  • Haveman, A. (1997). The open-/closed-class distinction in spoken-word recognition. PhD Thesis, Radboud University Nijmegen, Nijmegen. doi:10.17617/2.2057704.
  • Hay, J. B., & Baayen, R. H. (2005). Shifting paradigms: Gradient structure in morphology. Trends in Cognitive Sciences, 9(7), 342-348. doi:10.1016/j.tics.2005.04.002.

    Abstract

    Morphology is the study of the internal structure of words. A vigorous ongoing debate surrounds the question of how such internal structure is best accounted for: by means of lexical entries and deterministic symbolic rules, or by means of probabilistic subsymbolic networks implicitly encoding structural similarities in connection weights. In this review, we separate the question of subsymbolic versus symbolic implementation from the question of deterministic versus probabilistic structure. We outline a growing body of evidence, mostly external to the above debate, indicating that morphological structure is indeed intrinsically graded. By allowing probability into the grammar, progress can be made towards solving some long-standing puzzles in morphological theory.
  • De Hoop, H., & Narasimhan, B. (2005). Differential case-marking in Hindi. In M. Amberber, & H. de Hoop (Eds.), Competition and variation in natural languages: The case for case (pp. 321-345). Amsterdam: Elsevier.
  • Hoppenbrouwers, G., Seuren, P. A. M., & Weijters, A. (Eds.). (1985). Meaning and the lexicon. Dordrecht: Foris.
  • Houston, D. M., Jusczyk, P. W., Kuijpers, C., Coolen, R., & Cutler, A. (2000). Cross-language word segmentation by 9-month-olds. Psychonomic Bulletin & Review, 7, 504-509.

    Abstract

    Dutch-learning and English-learning 9-month-olds were tested, using the Headturn Preference Procedure, for their ability to segment Dutch words with strong/weak stress patterns from fluent Dutch speech. This prosodic pattern is highly typical for words of both languages. The infants were familiarized with pairs of words and then tested on four passages, two that included the familiarized words and two that did not. Both the Dutch- and the English-learning infants gave evidence of segmenting the targets from the passages, to an equivalent degree. Thus, English-learning infants are able to extract words from fluent speech in a language that is phonetically different from English. We discuss the possibility that this cross-language segmentation ability is aided by the similarity of the typical rhythmic structure of Dutch and English words.
  • Huettig, F., & Altmann, G. T. M. (2005). Word meaning and the control of eye fixation: Semantic competitor effects and the visual world paradigm. Cognition, 96(1), B23-B32. doi:10.1016/j.cognition.2004.10.003.

    Abstract

    When participants are presented simultaneously with spoken language and a visual display depicting objects to which that language refers, participants spontaneously fixate the visual referents of the words being heard [Cooper, R. M. (1974). The control of eye fixation by the meaning of spoken language: A new methodology for the real-time investigation of speech perception, memory, and language processing. Cognitive Psychology, 6(1), 84–107; Tanenhaus, M. K., Spivey-Knowlton, M. J., Eberhard, K. M., & Sedivy, J. C. (1995). Integration of visual and linguistic information in spoken language comprehension. Science, 268(5217), 1632–1634]. We demonstrate here that such spontaneous fixation can be driven by partial semantic overlap between a word and a visual object. Participants heard the word ‘piano’ when (a) a piano was depicted amongst unrelated distractors; (b) a trumpet was depicted amongst those same distractors; and (c), both the piano and trumpet were depicted. The probability of fixating the piano and the trumpet in the first two conditions rose as the word ‘piano’ unfolded. In the final condition, only fixations to the piano rose, although the trumpet was fixated more than the distractors. We conclude that eye movements are driven by the degree of match, along various dimensions that go beyond simple visual form, between a word and the mental representations of objects in the concurrent visual field.
  • Indefrey, P., Kleinschmidt, A., Merboldt, K.-D., Krüger, G., Brown, C. M., Hagoort, P., & Frahm, J. (1997). Equivalent responses to lexical and nonlexical visual stimuli in occipital cortex: a functional magnetic resonance imaging study. Neuroimage, 5, 78-81. doi:10.1006/nimg.1996.0232.

    Abstract

    Stimulus-related changes in cerebral blood oxygenation were measured using high-resolution functional magnetic resonance imaging sequentially covering visual occipital areas in contiguous sections. During dynamic imaging, healthy subjects silently viewed pseudowords, single false fonts, or length-matched strings of the same false fonts. The paradigm consisted of a sixfold alternation of an activation and a control task. With pseudowords as activation vs single false fonts as control, responses were seen mainly in medial occipital cortex. These responses disappeared when pseudowords were alternated with false font strings as the control and reappeared when false font strings instead of pseudowords served as activation and were alternated with single false fonts. The string-length contrast alone, therefore, is sufficient to account for the activation pattern observed in medial visual cortex when word-like stimuli are contrasted with single characters.
  • Indefrey, P. (1997). PET research in language production. In W. Hulstijn, H. F. M. Peters, & P. H. H. M. Van Lieshout (Eds.), Speech production: motor control, brain research and fluency disorders (pp. 269-278). Amsterdam: Elsevier.

    Abstract

    The aim of this paper is to discuss an inherent difficulty of PET (and fMRI) research in language production. On the one hand, language production presupposes some degree of freedom for the subject, on the other hand, interpretability of results presupposes restrictions of this freedom. This difficulty is reflected in the existing PET literature in some neglect of the general principle to design experiments in such a way that the results do not allow for alternative interpretations. It is argued that by narrowing down the scope of experiments a gain in interpretability can be achieved.
  • Indefrey, P., & Levelt, W. J. M. (2000). The neural correlates of language production. In M. S. Gazzaniga (Ed.), The new cognitive neurosciences; 2nd ed. (pp. 845-865). Cambridge, MA: MIT Press.

    Abstract

    This chapter reviews the findings of 58 word production experiments using different tasks and neuroimaging techniques. The reported cerebral activation sites are coded in a common anatomic reference system. Based on a functional model of language production, the different word production tasks are analyzed in terms of their processing components. This approach allows a distinction between the core process of word production and preceding task-specific processes (lead-in processes) such as visual or auditory stimulus recognition. The core process of word production is subserved by a left-lateralized perisylvian/thalamic language production network. Within this network there seems to be functional specialization for the processing stages of word production. In addition, this chapter includes a discussion of the available evidence on syntactic production, self-monitoring, and the time course of word production.
  • Ingvar, M., & Petersson, K. M. (2000). Functional maps and brain networks. In A. W. Toga (Ed.), Brain mapping: The systems (pp. 111-140). San Diego: Academic Press.
  • Janse, E., Sennema, A., & Slis, A. (2000). Fast speech timing in Dutch: The durational correlates of lexical stress and pitch accent. In Proceedings of the VIth International Conference on Spoken Language Processing, Vol. III (pp. 251-254).

    Abstract

    n this study we investigated the durational correlates of lexical stress and pitch accent at normal and fast speech rate in Dutch. Previous literature on English shows that durations of lexically unstressed vowels are reduced more than stressed vowels when speakers increase their speech rate. We found that the same holds for Dutch, irrespective of whether the unstressed vowel is schwa or a "full" vowel. In the same line, we expected that vowels in words without a pitch accent would be shortened relatively more than vowels in words with a pitch accent. This was not the case: if anything, the accented vowels were shortened relatively more than the unaccented vowels. We conclude that duration is an important cue for lexical stress, but not for pitch accent.
  • Janse, E. (2000). Intelligibility of time-compressed speech: Three ways of time-compression. In Proceedings of the VIth International Conference on Spoken Language Processing, vol. III (pp. 786-789).

    Abstract

    Studies on fast speech have shown that word-level timing of fast speech differs from that of normal rate speech in that unstressed syllables are shortened more than stressed syllables as speech rate increases. An earlier experiment showed that the intelligibility of time-compressed speech could not be improved by making its temporal organisation closer to natural fast speech. To test the hypothesis that segmental intelligibility is more important than prosodic timing in listening to timecompressed speech, the intelligibility of bisyllabic words was tested in three time-compression conditions: either stressed and unstressed syllable were compressed to the same degree, or the stressed syllable was compressed more than the unstressed syllable, or the reverse. As was found before, imitating wordlevel timing of fast speech did not improve intelligibility over linear compression. However, the results did not confirm the hypothesis either: there was no difference in intelligibility between the three compression conditions. We conclude that segmental intelligibility plays an important role, but further research is necessary to decide between the contributions of prosody and segmental intelligibility to the word-level intelligibility of time-compressed speech.
  • Janse, E. (2005). Lexical inhibition effects in time-compressed speech. In Proceedings of the 9th European Conference on Speech Communication and Technology [Interspeech 2005] (pp. 1757-1760).
  • Janse, E. (2005). Neighbourhood density effects in auditory nonword processing in aphasia. Brain and Language, 95, 24-25. doi:10.1016/j.bandl.2005.07.027.
  • Janzen, G., & Hawlik, M. (2005). Orientierung im Raum: Befunde zu Entscheidungspunkten. Zeitschrift für Psychology, 213, 179-186.
  • Janzen, G. (2005). Wie das mensliche Gehirn Orientierung ermöglicht. In G. Plehn (Ed.), Jahrbuch der Max-Planck-Gesellschaft (pp. 599-601). Göttingen: Vandenhoeck & Ruprecht.
  • Janzen, G., Herrmann, T., Katz, S., & Schweizer, K. (2000). Oblique Angled Intersections and Barriers: Navigating through a Virtual Maze. In Spatial Cognition II (pp. 277-294). Berlin: Springer.

    Abstract

    The configuration of a spatial layout has a substantial effect on the acquisition and the representation of the environment. In four experiments, we investigated navigation difficulties arising at oblique angled intersections. In the first three studies we investigated specific arrow-fork configurations. In dependence on the branch subjects use to enter the intersection different decision latencies and numbers of errors arise. If subjects see the intersection as a fork, it is more difficult to find the correct way as if it is seen as an arrow. In a fourth study we investigated different heuristics people use while making a detour around a barrier. Detour behaviour varies with the perspective. If subjects learn and navigate through the maze in a field perspective they use a heuristic of preferring right angled paths. If they have a view from above and acquire their knowledge in an observer perspective they use oblique angled paths more often.

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  • Jaspers, D., Klooster, W., Putseys, Y., & Seuren, P. A. M. (Eds.). (1989). Sentential complementation and the lexicon: Studies in honour of Wim de Geest. Dordrecht: Foris.
  • Jesse, A., Vrignaud, N., Cohen, M. M., & Massaro, D. W. (2000). The processing of information from multiple sources in simultaneous interpreting. Interpreting, 5(2), 95-115. doi:10.1075/intp.5.2.04jes.

    Abstract

    Language processing is influenced by multiple sources of information. We examined whether the performance in simultaneous interpreting would be improved when providing two sources of information, the auditory speech as well as corresponding lip-movements, in comparison to presenting the auditory speech alone. Although there was an improvement in sentence recognition when presented with visible speech, there was no difference in performance between these two presentation conditions when bilinguals simultaneously interpreted from English to German or from English to Spanish. The reason why visual speech did not contribute to performance could be the presentation of the auditory signal without noise (Massaro, 1998). This hypothesis should be tested in the future. Furthermore, it should be investigated if an effect of visible speech can be found for other contexts, when visual information could provide cues for emotions, prosody, or syntax.
  • Jesse, A., & Massaro, D. W. (2005). Towards a lexical fuzzy logical model of perception: The time-course of audiovisual speech processing in word identification. In E. Vatikiotis-Bateson, D. Burnham, & S. Fels (Eds.), Proceedings of the Auditory-Visual Speech Processing International Conference 2005 (pp. 35-36). Adelaide, Australia: Causal Productions.

    Abstract

    This study investigates the time-course of information processing in both visual as well as in the auditory speech as used for word identification in face-to-face communication. It extends the limited previous research on this topic and provides a valuable database for future research in audiovisual speech perception. An evaluation of models of speech perception by ear and eye in their ability to account for the audiovisual gating data shows a superior role of the fuzzy logical model of perception (FLMP) [1] over additive models of perception. A new dynamic version of the FLMP seems to be a promising model to account for the complex interplay of perceptual and cognitive information in audiovisual spoken word recognition.
  • Jesse, A. (2005). Towards a lexical fuzzy logical model of perception: The time-course of information in lexical identification of face-to-face speech. PhD Thesis, University of California, Santa Cruz.

    Abstract

    In face-to-face communication, information from the face as well as from the voice contributes to the identification of spoken words. This dissertation investigates the time-course of the evaluation and integration of visual and auditory speech in audiovisual word identification. A large-scale audiovisual gating study extends previous research on this topic by (1) using a set of words that includes all possible initial consonants in English in three vowel contexts, (2) tracking the information processing for individual words not only across modalities, but also over time, and (3) testing quantitative models of the time-course of multimodal word recognition. There was an advantage in accuracy for audiovisual speech over auditory-only and visual-only speech. Auditory performance was, however, close to ceiling while performance on visual-only trials was near the floor of the scale, but well above chance. Visual information was used at all gates to identify the presented words. Information theoretic feature analyses of the confusion matrices revealed that the auditory signal is highly informative about voicing, manner, frication, duration, and place of articulation. Visual speech is mostly informative about place of articulation, but also about frication and duration. The auditory signal provides more information about the place of articulation for back consonants, whereas the visual signal provides more information for the labial consonants. The data were sufficient to discriminate between models of audiovisual word recognition. The Fuzzy Logical Model of Perception (FLMP; Massaro, 1998) gave a better account of the confusion matrix data than additive models of perception. A dynamic version of the FLMP was expanded to account for the evaluation and integration of information over time. This dynamic FLMP provided a better description of the data than dynamic additive competitor models. The present study builds a good foundation to investigate the role of the complex interplay between stimulus information and the structure of the lexicon. It provides an important step in building a formal representation of a lexical dynamic FLMP that can account not only for the time-course of speech information and its perceptual processing, but also for lexical influences.
  • Johns, T. G., Vitali, A. A., Perera, R. M., Vernes, S. C., & Scott, A. M. (2005). Ligand-independent activation of the EGFRvIII: A naturally occurring mutation of the EGFR commonly expressed in glioma [Abstract]. Neuro-Oncology, 7, 299.

    Abstract

    Mutations of the epidermal growth factor receptor (EGFR) gene are found at a relatively high frequency in glioma, with the most common being the de2-7 EGFR (or EGFRvIII). This mutation arises from an in-frame deletion of exons 2–7, which removes 267 amino acids from the extracellular domain of the receptor. Despite being unable to bind ligand, the de2-7 EGFR is constitutively active at a low level. Transfection of human glioma cells with the de2-7 EGFR has little effect in vitro, but when grown as tumor xenografts this mutated receptor imparts a dramatic growth advantage. We have now mapped the phosphorylation pattern of de2-7 EGFR, both in vivo and in vitro, using a panel of antibodies unique to the different phosphorylated tyrosine residues. Phosphorylation of de2-7 EGFR was detected constitutively at all tyrosine sites surveyed both in vitro and in vivo, including tyrosine 845, a known target in the wild-type EGFR for src kinase. There was a substantial upregulation of phosphorylation at every tyrosine residue of the de2-7 EGFR when cells were grown in vivo compared to the receptor isolated from cells cultured in vitro. Upregulation of phosphorylation could be mimicked in vitro by the addition of specifi c components of the ECM such as collagen via an integrin-dependent mechanism. Since this increase in in vivo phosphorylation enhances de2-7 EGFR signaling, this observation explains why the growth enhancement mediated by de2-7 EGFR is largely restricted to the in vivo environment. In a second set of experiments we analyzed the interaction between EGFRvIII and ErbB2. Co-expression of these proteins in NR6 cells, a mouse fi broblast line devoid of ErbB family members, dramatically enhanced in vivo tumorigenicity of these cells compared to cells expressing either protein alone. Detailed analysis of these xenografts demonstrated that EGFRvIII could heterodimerize and transphosphorylate the ErbB2. Since both EGFRvIII and ErbB2 are commonly expressed at gliomas, this data suggests that the co-expression of these two proteins may enhance glioma tumorigenicity.
  • Johnson, E. K. (2005). English-learning infants' representations of word-forms with iambic stress. Infancy, 7(1), 95-105. doi:10.1207/s15327078in0701_8.

    Abstract

    Retaining detailed representations of unstressed syllables is a logical prerequisite for infants' use of probabilistic phonotactics to segment iambic words from fluent speech. The head-turn preference study was used to investigate the nature of English- learners' representations of iambic word onsets. Fifty-four 10.5-month-olds were familiarized to passages containing the nonsense iambic word forms ginome and tupong. Following familiarization, infants were either tested on familiar (ginome and tupong) or near-familiar (pinome and bupong) versus unfamiliar (kidar and mafoos) words. Infants in the familiar test group (familiar vs. unfamiliar) oriented significantly longer to familiar than unfamiliar test items, whereas infants in the near-familiar test group (near-familiar vs. unfamiliar) oriented equally long to near-familiar and unfamiliar test items. Our results provide evidence that infants retain fairly detailed representations of unstressed syllables and therefore support the hypothesis that infants use phonotactic cues to find words in fluent speech.
  • Johnson, E. K. (2005). Grammatical gender and early word recognition in Dutch. In A. Brugos, M. R. Clark-Cotton, & S. Ha (Eds.), Proceedings of the 29th Boston University Conference on Language Developement (pp. 320-330). Sommervile, MA: Cascadilla Press.
  • Johnson, E. K., Westrek, E., & Nazzi, T. (2005). Language familiarity affects voice discrimination by seven-month-olds. In Proceedings of the ISCA Workshop on Plasticity in Speech Perception (PSP2005) (pp. 227-230).
  • Johnson, E. K., Jusczyk, P. W., Cutler, A., & Norris, D. (2000). The development of word recognition: The use of the possible-word constraint by 12-month-olds. In L. Gleitman, & A. Joshi (Eds.), Proceedings of CogSci 2000 (pp. 1034). London: Erlbaum.
  • Johnsrude, I., Davis, M., & Hervais-Adelman, A. (2005). From sound to meaning: Hierarchical processing in speech comprehension. In D. Pressnitzer, S. McAdams, A. DeCheveigne, & L. Collet (Eds.), Auditory Signal Processing: Physiology, Psychoacoustics, and Models (pp. 299-306). New York: Springer.
  • Jolink, A. (2005). Finite linking in normally developing Dutch children and children with specific language impairment. Zeitschrift für Literaturwissenschaft und Linguistik, 140, 61-81.
  • Jordan, F., & Mace, R. (2005). The evolution of human sex-ratio at birth: A bio-cultural analysis. In R. Mace, C. J. Holden, & S. Shennan (Eds.), The evolution of cultural diversity: A phylogenetic approach (pp. 207-216). London: UCL Press.
  • Jordens, P. (1997). Introducing the basic variety. Second Language Research, 13(4), 289-300. doi:10.1191%2F026765897672176425.
  • Kelly, A., Narasimhan, B., & Smits, R. (2005). Max-Planck-Institute for Psycholinguistics: Annual Report 2005. Nijmegen: MPI for Psycholinguistics.
  • Kempen, G., & Harbusch, K. (2005). The relationship between grammaticality ratings and corpus frequencies: A case study into word order variability in the midfield of German clauses. In S. Kepser, & M. Reis (Eds.), Linguistic evidence - emperical, theoretical, and computational perspectives (pp. 329-349). Berlin: Mouton de Gruyter.
  • Kempen, G., Anbeek, G., Desain, P., Konst, L., & De Smedt, K. (1987). Auteursomgevingen: Vijfde-generatie tekstverwerkers. Informatie, 29, 988-993.
  • Kempen, G., Anbeek, G., Desain, P., Konst, L., & De Semdt, K. (1987). Author environments: Fifth generation text processors. In Commission of the European Communities. Directorate-General for Telecommunications, Information Industries, and Innovation (Ed.), Esprit'86: Results and achievements (pp. 365-372). Amsterdam: Elsevier Science Publishers.
  • Kempen, G., Anbeek, G., Desain, P., Konst, L., & De Smedt, K. (1987). Author environments: Fifth generation text processors. In Commission of the European Communities. Directorate-General for Telecommunications, Information Industries, and Innovation (Ed.), Esprit'86: Results and achievements (pp. 365-372). Amsterdam: Elsevier Science Publishers.
  • Kempen, G. (1996). Computational models of syntactic processing in human language comprehension. In T. Dijkstra, & K. De Smedt (Eds.), Computational psycholinguistics: Symbolic and subsymbolic models of language processing (pp. 192-220). London: Taylor & Francis.
  • Kempen, G. (1997). De ontdubbelde taalgebruiker: Maken taalproductie en taalperceptie gebruik van één en dezelfde syntactische processor? [Abstract]. In 6e Winter Congres NvP. Programma and abstracts (pp. 31-32). Nederlandse Vereniging voor Psychonomie.
  • Kempen, G., Kooij, A., & Van Leeuwen, T. (1997). Do skilled readers exploit inflectional spelling cues that do not mirror pronunciation? An eye movement study of morpho-syntactic parsing in Dutch. In Abstracts of the Orthography Workshop "What spelling changes". Nijmegen: Max Planck Institute for Psycholinguistics.
  • Kempen, G., & Hoenkamp, E. (1987). An incremental procedural grammar for sentence formulation. Cognitive Science, 11(2), 201-258.

    Abstract

    This paper presents a theory of the syntactic aspects of human sentence production. An important characteristic of unprepared speech is that overt pronunciation of a sentence can be initiated before the speaker has completely worked out the meaning content he or she is going to express in that sentence. Apparently, the speaker is able to build up a syntactically coherent utterance out of a series of syntactic fragments each rendering a new part of the meaning content. This incremental, left-to-right mode of sentence production is the central capability of the proposed Incremental Procedural Grammar (IPG). Certain other properties of spontaneous speech, as derivable from speech errors, hesitations, self-repairs, and language pathology, are accounted for as well. The psychological plausibility thus gained by the grammar appears compatible with a satisfactory level of linguistic plausibility in that sentences receive structural descriptions which are in line with current theories of grammar. More importantly, an explanation for the existence of configurational conditions on transformations and other linguistics rules is proposed. The basic design feature of IPG which gives rise to these psychologically and linguistically desirable properties, is the “Procedures + Stack” concept. Sentences are built not by a central constructing agency which overlooks the whole process but by a team of syntactic procedures (modules) which work-in parallel-on small parts of the sentence, have only a limited overview, and whose sole communication channel is a stock. IPG covers object complement constructions, interrogatives, and word order in main and subordinate clauses. It handles unbounded dependencies, cross-serial dependencies and coordination phenomena such as gapping and conjunction reduction. It is also capable of generating self-repairs and elliptical answers to questions. IPG has been implemented as an incremental Dutch sentence generator written in LISP.
  • Kempen, G. (1985). Artificiële intelligentie: Bouw, benutting, beheersing. In W. Veldkamp (Ed.), Innovatie in perspectief (pp. 42-47). Vianen: Nixdorf Computer B.V.
  • Kempen, G. (1996). "De zwoele groei van den zinsbouw": De wonderlijke levende grammatica van Jac. van Ginneken uit De Roman van een Kleuter (1917). Bezorgd en van een nawoord voorzien door Gerard Kempen. In A. Foolen, & J. Noordegraaf (Eds.), De taal is kennis van de ziel: Opstellen over Jac. van Ginneken (1877-1945) (pp. 173-216). Münster: Nodus Publikationen.
  • Kempen, G. (2000). Could grammatical encoding and grammatical decoding be subserved by the same processing module? Behavioral and Brain Sciences, 23, 38-39.
  • Kempen, G. (1996). Human language technology can modernize writing and grammar instruction. In COLING '96 Proceedings of the 16th conference on Computational linguistics - Volume 2 (pp. 1005-1006). Stroudsburg, PA: Association for Computational Linguistics.
  • Kempen, G., & Vosse, T. (1989). Incremental syntactic tree formation in human sentence processing: A cognitive architecture based on activation decay and simulated annealing. Connection Science, 1(3), 273-290. doi:10.1080/09540098908915642.

    Abstract

    A new cognitive architecture is proposed for the syntactic aspects of human sentence processing. The architecture, called Unification Space, is biologically inspired but not based on neural nets. Instead it relies on biosynthesis as a basic metaphor. We use simulated annealing as an optimization technique which searches for the best configuration of isolated syntactic segments or subtrees in the final parse tree. The gradually decaying activation of individual syntactic nodes determines the ‘global excitation level’ of the system. This parameter serves the function of ‘computational temperature’ in simulated annealing. We have built a computer implementation of the architecture which simulates well-known sentence understanding phenomena. We report successful simulations of the psycholinguistic effects of clause embedding, minimal attachment, right association and lexical ambiguity. In addition, we simulated impaired sentence understanding as observable in agrammatic patients. Since the Unification Space allows for contextual (semantic and pragmatic) influences on the syntactic tree formation process, it belongs to the class of interactive sentence processing models.
  • Kempen, G. (1989). Informatiegedragskunde: Pijler van de moderne informatieverzorging. In A. F. Marks (Ed.), Sociaal-wetenschappelijke informatie en kennisvorming in onderzoek, onderzoeksbeleid en beroep (pp. 31-35). Amsterdam: SWIDOC.
  • Kempen, G. (1989). Language generation systems. In I. S. Bátori, W. Lenders, & W. Putschke (Eds.), Computational linguistics: An international handbook on computer oriented language research and applications (pp. 471-480). Berlin/New York: Walter de Gruyter.
  • Kempen, G. (1996). Lezen, leren lezen, dyslexie: De auditieve basis van visuele woordherkenning. Nederlands Tijdschrift voor de Psychologie, 51, 91-100.
  • Kempen, G. (Ed.). (1987). Natural language generation: New results in artificial intelligence, psychology and linguistics. Dordrecht: Nijhoff.
  • Kempen, G. (Ed.). (1987). Natuurlijke taal en kunstmatige intelligentie: Taal tussen mens en machine. Groningen: Wolters-Noordhoff.
  • Kempen, G., & Olsthoorn, N. (2005). Non-parallelism of grammatical encoding and decoding due to shared working memory [Abstract]. In AMLaP-2005 11th Annual Conference on Architectures and Mechanisms for Language Processing September 5-7, 2005 Ghent, Belgium (pp. 24).
  • Kempen, G., & Janssen, S. (1996). Omspellen: Reuze(n)karwei of peule(n)schil? In H. Croll, & J. Creutzberg (Eds.), Proceedings of the 5e Dag van het Document (pp. 143-146). Projectbureau Croll en Creutzberg.
  • Kempen, G. (1985). Psychologie 2000. Toegepaste psychologie in de informatiemaatschappij. Computers in de psychologie, 13-21.
  • Kempen, G. (1987). Tekstverwerking: De vijfde generatie. Informatie, 29, 402-406.
  • Kempen, G. (1997). Taalpsychologie week. In Wetenschappelijke Scheurkalender 1998. Beek: Natuur & Techniek.

    Abstract

    [Seven one-page psycholinguistic sketches]
  • Kempen, G., Schotel, H., & Pijls, J. (1985). Taaltechnologie en taalonderwijs. In J. Heene (Ed.), Onderwijs en informatietechnologie. Den Haag: Stichting voor Onderzoek van het Onderwijs (SVO).
  • Kempen, G. (1996). Wetenschap op internet: Een voorstel voor de Nederlandse Psychonomie. Nieuwsbrief Nederlandse Vereniging voor Psychonomie, 3, 5-8.
  • Kempen, G. (1997). Van taalbarrières naar linguïstische snelwegen: Inrichting van een technische taalinfrastructuur voor het Nederlands. Grenzen aan veeltaligheid: Taalgebruik en bestuurlijke doeltreffendheid in de instellingen van de Europese Unie, 43-48.
  • Kemps, R. J. J. K., Wurm, L. H., Ernestus, M., Schreuder, R., & Baayen, R. H. (2005). Prosodic cues for morphological complexity in Dutch and English. Language and Cognitive Processes, 20(1/2), 43-73. doi:10.1080/01690960444000223.

    Abstract

    Previous work has shown that Dutch listeners use prosodic information in the speech signal to optimise morphological processing: Listeners are sensitive to prosodic differences between a noun stem realised in isolation and a noun stem realised as part of a plural form (in which the stem is followed by an unstressed syllable). The present study, employing a lexical decision task, provides an additional demonstration of listeners' sensitivity to prosodic cues in the stem. This sensitivity is shown for two languages that differ in morphological productivity: Dutch and English. The degree of morphological productivity does not correlate with listeners' sensitivity to prosodic cues in the stem, but it is reflected in differential sensitivities to the word-specific log odds ratio of encountering an unshortened stem (i.e., a stem in isolation) versus encountering a shortened stem (i.e., a stem followed by a suffix consisting of one or more unstressed syllables). In addition to being sensitive to the prosodic cues themselves, listeners are also sensitive to the probabilities of occurrence of these prosodic cues.
  • Kemps, R. J. J. K., Ernestus, M., Schreuder, R., & Baayen, R. H. (2005). Prosodic cues for morphological complexity: The case of Dutch plural nouns. Memory & Cognition, 33(3), 430-446.

    Abstract

    It has recently been shown that listeners use systematic differences in vowel length and intonation to resolve ambiguities between onset-matched simple words (Davis, Marslen-Wilson, & Gaskell, 2002; Salverda, Dahan, & McQueen, 2003). The present study shows that listeners also use prosodic information in the speech signal to optimize morphological processing. The precise acoustic realization of the stem provides crucial information to the listener about the morphological context in which the stem appears and attenuates the competition between stored inflectional variants. We argue that listeners are able to make use of prosodic information, even though the speech signal is highly variable within and between speakers, by virtue of the relative invariance of the duration of the onset. This provides listeners with a baseline against which the durational cues in a vowel and a coda can be evaluated. Furthermore, our experiments provide evidence for item-specific prosodic effects.
  • Keune, K., Ernestus, M., Van Hout, R., & Baayen, R. H. (2005). Variation in Dutch: From written "mogelijk" to spoken "mok". Corpus Linguistics and Linguistic Theory, 1(2), 183-223. doi:10.1515/cllt.2005.1.2.183.

    Abstract

    In Dutch, high-frequency words with the suffix -lijk are often highly reduced in spontaneous unscripted speech. This study addressed socio-geographic variation in the reduction of such words against the backdrop of the variation in their use in written and spoken Dutch. Multivariate analyses of the frequencies with which the words were used in a factorially contrasted set of subcorpora revealed signi ficant variation involving the speaker's country, sex, and education level for spoken Dutch, and involving country and register for written Dutch. Acoustic analyses revealed that Dutch men reduced most often, while Flemish highly educated women reduced least. Two linguistic context effects emerged, one prosodic, and the other pertaining to the flow of information. Words in sentence final position showed less reduction, while words that were better predictable from the preceding word in the sentence(based on mutual information) tended to be reduced more often. The increased probability of reduction for forms that are more predictable in context, combined with the loss of the suffix in the more extremely reduced forms, suggests that highfrequency words in -lijk are undergoing a process of erosion that causes them to gravitate towards monomorphemic function words.
  • Kidd, E., & Bavin, E. L. (2005). Lexical and referential cues to sentence interpretation: An investigation of children's interpretations of ambiguous sentences. Journal of Child Language, 32(4), 855-876. doi:10.1017/S0305000905007051.

    Abstract

    This paper reports on an investigation of children's (aged 3;5–9;8) comprehension of sentences containing ambiguity of prepositional phrase (PP) attachment. Results from a picture selection study (N=90) showed that children use verb semantics and preposition type to resolve the ambiguity, with older children also showing sensitivity to the definiteness of the object NP as a cue to interpretation. Study 2 investigated three- and five-year-old children's (N=47) ability to override an instrumental interpretation of ambiguous PPs in order to process attributes of the referential scene. The results showed that while five-year-olds are capable of incorporating aspects of the referential scene into their interpretations, three-year-olds are not as successful. Overall, the results suggest that children are attuned very early to the lexico-semantic co-occurrences that have been shown to aid ambiguity resolution in adults, but that more diffuse cues to interpretation are used only later in development
  • Kilborn, K., & Weissenborn, J. (1989). Max-Planck-Institute for Psycholinguistics: Annual Report Nr.10 1989. Nijmegen: MPI for Psycholinguistics.
  • Kita, S. (1997). Miburi to Kotoba [gesture and speech]. In H. Kobayashi, & M. Sasaki (Eds.), Kodomotachi no gengokakutoku [Child language development] (pp. 68-84). Tokyo, Japan: Taishukan.
  • Kita, S. (1997). Two-dimensional semantic analysis of Japanese mimetics. Linguistics, 35, 379-415. doi:10.1515/ling.1997.35.2.379.
  • Klein, W. (2005). Söldner des Wissens. In R. Kiesow, R. Ogorek, & S. Simitis (Eds.), Summa: Dieter Simon zum 70. Geburtstag (pp. 319-332). Frankfurt am Main: Klostermann.
  • Klein, W., & Dimroth, C. (Eds.). (2005). Spracherwerb [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, 140.
  • Klein, W. (2005). The grammar of varieties. In U. Ammon, N. Dittmar, K. J. Mattheier, & P. Trudgill (Eds.), Sociolinguistics: An international handbook of the Science of Language and Society (pp. 1163-1171). Berlin: Walter de Gruyter.
  • Klein, W. (2005). Über den Nutzen naturwissenschaftlicher Denkmodelle für die Geisteswissenschaften. Debatte, 2, 45-50.
  • Klein, W. (2005). Vom Sprachvermögen zum Sprachlichen System. Zeitschrift für Literaturwissenschaft und Linguistik, 140, 8-39.
  • Klein, W. (2005). Wie ist eine exakte Wissenschaft von der Literatur möglich? Zeitschrift für Literaturwissenschaft und Linguistik, 137, 80-100.
  • Klein, W. (2000). Changing concepts of the nature-nurture debate. In R. Hide, J. Mittelstrass, & W. Singer (Eds.), Changing concepts of nature at the turn of the millenium: Proceedings plenary session of the Pontifical academy of sciences, 26-29 October 1998 (pp. 289-299). Vatican City: Pontificia Academia Scientiarum.
  • Klein, W. (1987). Das Geltende, oder: System der Überzeugungen. Zeitschrift für Literaturwissenschaft und Linguistik, (64), 10-31.
  • Klein, W., & Schlieben-Lange, B. (1996). Das Ich und die Sprache. Zeitschrift für Literaturwissenschaft und Linguistik, 101, 1-5.
  • Klein, W. (2000). Der Mythos vom Sprachverfall. In Berlin-Brandenburgische Akademie der Wissenschaften (Ed.), Jahrbuch 1999: Berlin-Brandenburgische Akademie der Wissenschaften (pp. 139-158). Berlin: Akademie Verlag.
  • Klein, W. (1987). Eine Verschärfung des Entscheidungsproblems. Rechtshistorisches Journal, 6, 209-210.
  • Klein, W. (1985). Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, 15(59), 7-8.
  • Klein, W. (1985). Ellipse, Fokusgliederung und thematischer Stand. In R. Meyer-Hermann, & H. Rieser (Eds.), Ellipsen und fragmentarische Ausdrücke (pp. 1-24). Tübingen: Niemeyer.
  • Klein, W. (1996). Essentially social: On the origin of linguistic knowledge in the individual. In P. Baltes, & U. Staudinger (Eds.), Interactive minds (pp. 88-107). Cambridge: Cambridge University Press.
  • Klein, W. (2000). An analysis of the German perfekt. Language, 76, 358-382.

    Abstract

    The German Perfekt has two quite different temporal readings, as illustrated by the two possible continuations of the sentence Peter hat gearbeitet in i, ii, respectively: (i) Peter hat gearbeitet und ist müde. Peter has worked and is tired. (ii) Peter hat gearbeitet und wollte nicht gestört werden. Peter has worked and wanted not to be disturbed. The first reading essentially corresponds to the English present perfect; the second can take a temporal adverbial with past time reference ('yesterday at five', 'when the phone rang', and so on), and an English translation would require a past tense ('Peter worked/was working'). This article shows that the Perfekt has a uniform temporal meaning that results systematically from the interaction of its three components-finiteness marking, auxiliary and past participle-and that the two readings are the consequence of a structural ambiguity. This analysis also predicts the properties of other participle constructions, in particular the passive in German.
  • Klein, W. (1985). Argumentationsanalyse: Ein Begriffsrahmen und ein Beispiel. In W. Kopperschmidt, & H. Schanze (Eds.), Argumente - Argumentationen (pp. 208-260). München: Fink.
  • Klein, W., Li, P., & Hendriks, H. (2000). Aspect and assertion in Mandarin Chinese. Natural Language & Linguistic Theory, 18, 723-770. doi:10.1023/A:1006411825993.

    Abstract

    Chinese has a number of particles such as le, guo, zai and zhe that add a particular aspectual value to the verb to which they are attached. There have been many characterisations of this value in the literature. In this paper, we review several existing influential accounts of these particles, including those in Li and Thompson (1981), Smith (1991), and Mangione and Li (1993). We argue that all these characterisations are intuitively plausible, but none of them is precise.We propose that these particles serve to mark which part of the sentence''s descriptive content is asserted, and that their aspectual value is a consequence of this function. We provide a simple and precise definition of the meanings of le, guo, zai and zhe in terms of the relationship between topic time and time of situation, and show the consequences of their interaction with different verb expressions within thisnew framework of interpretation.
  • Klein, W. (2005). Der alte und der neue Grimm. In Grimm-Sozietät (Ed.), Die Brüder Grimm in Berlin (pp. 167-176). Stuttgart: Hirzel.
  • Klein, W. (2005). Hoe is een exacte literatuurwetenschap mogelijk? Parmentier, 14(1), 48-65.
  • Klein, W. (Ed.). (2005). Nicht nur Literatur [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, 137.
  • Klein, W. (2000). Fatale Traditionen. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, (120), 11-40.

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