Publications

Abstract

Q fever, caused by Coxiella burnetii, is a zoonosis with a worldwide distribution. A large rural area in the southeast of the Netherlands was heavily affected by Q fever between 2007 and 2009. This initiated the development of a robust and internally controlled multiplex quantitative PCR (qPCR) assay for the detection of C. burnetii DNA in veterinary and environmental matrices on suspected Q fever-affected farms. The qPCR detects three C. burnetii targets (icd, com1, and IS1111) and one Bacillus thuringiensis internal control target (cry1b). Bacillus thuringiensis spores were added to samples to control both DNA extraction and PCR amplification. The performance of the qPCR assay was investigated and showed a high efficiency; a limit of detection of 13.0, 10.6, and 10.4 copies per reaction for the targets icd, com1, and IS1111, respectively; and no crossreactivity with the nontarget organisms tested. Screening for C. burnetii DNA on 29 suspected Q fever-affected farms during the Q fever epidemic in 2008 showed that swabs from dust-accumulating surfaces contained higher levels of C. burnetii DNA than vaginal swabs from goats or sheep. PCR inhibition by coextracted substances was observed in some environmental samples, and 10- or 100-fold dilutions of samples were sufficient to obtain interpretable signals for both the C. burnetii targets and the internal control. The inclusion of an internal control target and three C. burnetii targets in one multiplex qPCR assay showed that complex veterinary and environmental matrices can be screened reliably for the presence of C. burnetii DNA during an outbreak. © 2011, American Society for Microbiology.

Abstract

We investigated localization performance of simple targets in patient TN, who suffered bilateral damage of his primary visual cortex and shows complete cortical blindness. Using a two-alternative forced-choice paradigm, TN was asked to guess the position of left-right targets with goal-directed and discrete manual responses. The results indicate a clear dissociation between goal-directed and discrete responses. TN pointed toward the correct target location in approximately 75% of the trials but was at chance level with discrete responses. This indicates that the residual ability to localize an unseen stimulus depends critically on the possibility to translate a visual signal into a goal-directed motor output at least in certain forms of blindsight.

Abstract

Introduction
Despite abundant research on the role of Broca's area in language processing, there is still no consensus on language specificity of this region and its connectivity network.

Methods
The present study employed the meta-analytic connectivity modeling procedure to identify and compare domain-specific (language-specific) and domain-general (shared between language and other domains) functional connectivity patterns of three subdivisions within the broadly defined Broca's area: pars opercularis (IFGop), pars triangularis (IFGtri), and pars orbitalis (IFGorb) of the left inferior frontal gyrus.

Results
The findings revealed a left-lateralized frontotemporal network for all regions of interest underlying domain-specific linguistic functions. The domain-general network, however, spanned frontoparietal regions that overlap with the multiple-demand network and subcortical regions spanning the thalamus and the basal ganglia.

Conclusions
The findings suggest that language specificity of Broca's area emerges within a left-lateralized frontotemporal network, and that domain-general resources are garnered from frontoparietal and subcortical networks when required by task demands.

Abstract

Use of peripheral blood- or bone marrow-derived progenitors for ischemic heart repair is a feasible option to induce neo-vascularization in ischemic tissues. These cells, named Endothelial Progenitors Cells (EPCs), have been extensively characterized phenotypically and functionally. The clinical efficacy of cardiac repair by EPCs cells remains, however, limited, due to cell autonomous defects as a consequence of risk factors. The devise of “enhancement” strategies has been therefore sought to improve repair ability of these cells and increase the clinical benefit

Abstract

The cognitive- and neurosciences have supposed that the perceptual world of the individual is dominated by vision, followed closely by audition, but that olfaction is merely vestigial. Aslian-speaking communities (Austroasiatic, Malay Peninsula) challenge this view. For the Jahai - a small group of rainforest foragers - odor plays a central role in both culture and language. Jahai ideology revolves around a complex set of beliefs that structures the human relationship with the supernatural. Central to this relationship are hearing, vision, and olfaction. In Jahai language, olfaction also receives special attention. There are at least a dozen or so abstract descriptive odor categories that are basic, everyday terms. This lexical elaboration of odor is not unique to the Jahai but can be seen across many contemporary Austroasiatic languages and transcends major cultural and environmental boundaries. These terms appear to be inherited from ancestral language states, suggesting a longstanding preoccupation with odor in this part of the world. Contrary to the prevailing assumption in the cognitive sciences, these languages and cultures demonstrate that odor is far from vestigial in humans.

Abstract

This work explores the linguistic encoding of reciprocal events in Jahai (Aslian, Mon-Khmer, Malay Peninsula) on the basis of linguistic descriptions of the video stimuli of the ‘Reciprocal constructions and situation type’ task (Evans et al. 2004). Reciprocal situation types find expression in three different constructions: distributive verb forms, reciprocal verb forms, and adjunct phrases containing a body part noun. Distributives represent the dominant strategy, reciprocal forms and body part adjuncts being highly restricted across event types and consultants. The distributive and reciprocal morphemes manifest intricate morphological processes typical of Aslian languages. The paper also addresses some analytical problems raised by the data, such as structural ambiguity and restrictions on derivation, as well as individual variation.

Abstract

Semplates are a new descriptive and theoretical concept in lexical semantics, borne out of recent L&C work in several domains. A semplate can be defined as a configuration consisting of distinct layers of lexemes, each layer drawn from a different form class, mapped onto the same abstract semantic template. Within such a lexical layer, the sense relations between the lexical items are inherited from the underlying template. Thus, the whole set of lexical layers and the underlying template form a cross-categorial configuration in the lexicon. The goal of this task is to find new kinds of macrostructure in the lexicon, with a view to cross-linguistic comparison.

Abstract

This paper reports tentatively some features of Semnam, a Central Aslian language spoken by some 250 people in the Perak valley, Peninsular Malaysia. It outlines the unusually rich phonemic system of this hitherto undescribed language (e.g. a vowel system comprising 36 distinctive nuclei), and proposes a practical orthography for it. It also includes the c. 1,250- item wordlist on which the analysis is based, collected intermittently in the field 2006-2008.

Abstract

This study presents an analysis of over 4000 tokens of words produced as variants with and without schwa in a French corpus of radio-broadcasted speech. In order to determine which of the many variables mentioned in the literature influence variant choice, 17 predictors were tested in the same analysis. Only five of these variables appeared to condition variant choice. The question of the processing stage, or locus, of this alternation process is also addressed in a comparison of the variables that predict variant choice with the variables that predict the acoustic duration of schwa in variants with schwa. Only two variables predicting variant choice also predict schwa duration. The limited overlap between the predictors for variant choice and for schwa duration, combined with the nature of these variables, suggest that the variants without schwa do not result from a phonetic process of reduction; that is, they are not the endpoint of gradient schwa shortening. Rather, these variants are generated early in the production process, either during phonological encoding or word-form retrieval. These results, based on naturally produced speech, provide a useful complement to on-line production experiments using artificial speech tasks.

Abstract

Large auditory-visual (AV) speech corpora are the grist of modern research in speech science, but no such corpus exists for Australian English. This is unfortunate, for speech science is the brains behind speech technology and applications such as text-to-speech (TTS) synthesis, automatic speech recognition (ASR), speaker recognition and forensic identification, talking heads, and hearing prostheses. Advances in these research areas in Australia require a large corpus of Australian English. Here the authors describe a blueprint for building the Big Australian Speech Corpus (the Big ASC), a corpus of over 1,100 speakers from urban and rural Australia, including speakers of non-indigenous, indigenous, ethnocultural, and disordered forms of Australian English, each of whom would be sampled on three occasions in a range of speech tasks designed by the researchers who would be using the corpus.

Abstract

Cortical blindness refers to the loss of vision that occurs after destruction of the primary visual cortex. Although there is no sensory cortex and hence no conscious vision, some cortically blind patients show amygdala activation in response to facial or bodily expressions of emotion. Here we investigated whether direction of gaze could also be processed in the absence of any functional visual cortex. A well-known patient with bilateral destruction of his visual cortex and subsequent cortical blindness was investigated in an fMRI paradigm during which blocks of faces were presented either with their gaze directed toward or away from the viewer. Increased right amygdala activation was found in response to directed compared with averted gaze. Activity in this region was further found to be functionally connected to a larger network associated with face and gaze processing. The present study demonstrates that, in human subjects, the amygdala response to eye contact does not require an intact primary visual cortex.

Abstract

This chapter provides an introduction to the handbook. It succintly overviews the key questions in the field of L3/Ln acquisition and summarizes the scope of all the chapters included. The chapter ends by raising some outstanding questions that the field needs to address.

Abstract

Much evidence has suggested that people conceive of time as flowing directionally in transverse space (e.g., from left to right for English speakers). However, this phenomenon has never been tested in a fully nonlinguistic paradigm where neither stimuli nor task use linguistic labels, which raises the possibility that time is directional only when reading/writing direction has been evoked. In the present study, English-speaking participants viewed a video where an actor sang a note while gesturing and reproduced the duration of the sung note by pressing a button. Results showed that the perceived duration of the note was increased by a long-distance gesture, relative to a short-distance gesture. This effect was equally strong for gestures moving from left to right and from right to left and was not dependent on gestures depicting movement through space; a weaker version of the effect emerged with static gestures depicting spatial distance. Since both our gesture stimuli and temporal reproduction task were nonlinguistic, we conclude that the spatial representation of time is nondirectional: Movement contributes, but is not necessary, to the representation of temporal information in a transverse timeline.

Abstract

Purpose: To investigate masking release for speech maskers for linguistically and phonetically close (English and Dutch) and distant (English and Mandarin) language pairs. Method: Thirty-two monolingual speakers of English with normal audiometric thresholds participated in the study. Data are reported for an English sentence recognition task in English and for Dutch and Mandarin competing speech maskers (Experiment 1) and noise maskers (Experiment 2) that were matched either to the long-term average speech spectra or to the temporal modulations of the speech maskers from Experiment 1. Results: Listener performance increased as the target-tomasker linguistic distance increased (English-in-English < English-in-Dutch < English-in-Mandarin). Conclusion: Spectral differences between maskers can account for some, but not all, of the variation in performance between maskers; however, temporal differences did not seem to play a significant role.

Abstract

The influence of culture on cognitive development is well established for school age and older children. But almost nothing is known about how different parenting and socialization practices in different cultures affect infants' and young children's earliest emerging cognitive and social-cognitive skills. In the current monograph, we report a series of eight studies in which we systematically assessed the social-cognitive skills of 1- to 3-year-old children in three diverse cultural settings. One group of children was from a Western, middle-class cultural setting in rural Canada and the other two groups were from traditional, small-scale cultural settings in rural Peru and India. In a first group of studies, we assessed 1-year-old children's most basic social-cognitive skills for understanding the intentions and attention of others: imitation, helping, gaze following, and communicative pointing. Children's performance in these tasks was mostly similar across cultural settings. In a second group of studies, we assessed 1-year-old children's skills in participating in interactive episodes of collaboration and joint attention. Again in these studies the general finding was one of cross-cultural similarity. In a final pair of studies, we assessed 2- to 3-year-old children's skills within two symbolic systems (pretense and pictorial). Here we found that the Canadian children who had much more experience with such symbols showed skills at an earlier age. Our overall conclusion is that young children in all cultural settings get sufficient amounts of the right kinds of social experience to develop their most basic social-cognitive skills for interacting with others and participating in culture at around the same age. In contrast, children's acquisition of more culturally specific skills for use in practices involving artifacts and symbols is more dependent on specific learning experiences.

Abstract

Humans are the only species that uses communication to teach new knowledge to novices, usually to children (Tomasello, 1999 and Csibra and Gergely, 2006). This context of communication can employ “demonstrations” and it takes place with or without the help of objects (Clark, 1996). Previous research has focused on understanding the nature of demonstrations for very young children and with objects involved. However, little is known about the strategies used in demonstrating an action to an older child in comparison to another adult and without the use of objects, i.e., with gestures only. We tested if during demonstration of an action speakers use different degrees of iconicity in gestures for a child compared to an adult. 18 Italian subjects described to a camera how to make coffee imagining the listener as a 12-year-old child, a novice or an expert adult. While speech was found more informative both for the novice adult and for the child compared to the expert adult, the rate of iconic gestures increased and they were more informative and bigger only for the child compared to both of the adult conditions. Iconicity in gestures can be a powerful communicative strategy in teaching new knowledge to children in demonstrations and this is in line with claims that it can be used as a scaffolding device in grounding knowledge in experience (Perniss et al., 2010).

Abstract

In order to understand early word learning we need to better understand and quantify properties of the input that young children receive. We extended the human simulation paradigm (HSP) using egocentric videos taken from infant head-mounted cameras. The videos were further annotated with gaze information indicating in-the-moment visual attention from the infant. Our new HSP prompted participants for two types of responses, thus differentiating referential from semantic ambiguity in the learning input. Consistent with findings on visual attention in word learning, we find a strongly bimodal distribution over HSP accuracy. Even in this open-ended task, most videos only lead to a small handful of common responses. What's more, referential ambiguity was the key bottleneck to performance: participants can nearly always recover the exact word that was said if they identify the correct referent. Finally, analysis shows that adult learners relied on particular, multimodal behavioral cues to infer those target referents.

Abstract

We call those gestures “instrumental” that can enhance certain thinking processes of an agent by offering him representational models of his actions in a virtual space of imaginary performative possibilities. We argue that pointing is an instrumental gesture in that it represents geometrical information on one’s own gaze direction (i.e., a spatial model for attentional/ocular fixation/orientation), and provides a ritualized template for initiating gaze coordination and joint attention. We counter two possible objections, asserting respectively that the representational content of pointing is not constitutive, but derived from language, and that pointing directly solicits gaze coordination, without representing it. We consider two studies suggesting that attention and spatial perception are actively modified by one’s own pointing activity: the first study shows that pointing gestures help children link sets of objects to their corresponding number words; the second, that adults are faster and more accurate in counting when they point.

Abstract

Madagascar is located at the crossroads of the Asian and African worlds and is therefore of particular interest for studies on human population migration. Within the large human diversity of the Great Island, we focused our study on a particular ethnic group, the Antemoro. Their culture presents an important Arab-Islamic influence, but the question of an Arab biological inheritance remains unresolved. We analyzed paternal (n=129) and maternal (n=135) lineages of this ethnic group. Although the majority of Antemoro genetic ancestry comes from sub-Saharan African and Southeast Asian gene pools, we observed in their paternal lineages two specific haplogroups (J1 and T1) linked to Middle Eastern origins. This inheritance was restricted to some Antemoro sub-groups. Statistical analyses tended to confirm significant Middle Eastern genetic contribution. This study gives a new perspective to the large human genetic diversity in Madagascar

Abstract

Rapid response to danger holds an evolutionary advantage. In this positron emission tomography study, phobics were exposed to masked visual stimuli with timings that either allowed awareness or not of either phobic, fear-relevant (e.g., spiders to snake phobics), or neutral images. When the timing did not permit awareness, the amygdala responded to both phobic and fear-relevant stimuli. With time for more elaborate processing, phobic stimuli resulted in an addition of an affective processing network to the amygdala activity, whereas no activity was found in response to fear-relevant stimuli. Also, right prefrontal areas appeared deactivated, comparing aware phobic and fear-relevant conditions. Thus, a shift from top-down control to an affectively driven system optimized for speed was observed in phobic relative to fear-relevant aware processing.

Abstract

Neuronal populations code similar concepts by similar activity patterns across the human brain's semantic networks. However, it is unclear to what extent such meaning-to-symbol mapping reflects distributional statistics, or experiential information grounded in sensorimotor and emotional knowledge. We asked whether integrating distributional and experiential data better distinguished conceptual categories than each method taken separately. We examined the similarity structure of fMRI patterns elicited by visually presented action- and object-related words using representational similarity analysis (RSA). We found that the distributional and experiential/integrative models respectively mapped the high-dimensional semantic space in left inferior frontal, anterior temporal, and in left precentral, posterior inferior/middle temporal cortex. Furthermore, results from model comparisons uncovered category-specific similarity patterns, as both distributional and experiential models matched the similarity patterns for action concepts in left fronto-temporal cortex, whilst the experiential/integrative (but not distributional) models matched the similarity patterns for object concepts in left fusiform and angular gyrus.

Abstract

Speaking requires the temporally coordinated planning of core linguistic information, from conceptual meaning to articulation. Recent neurophysiological results suggested that these operations involve a cascade of neural events with subsequent onset times, whilst competing evidence suggests early parallel neural activation. To test these hypotheses, we examined the sources of neuromagnetic activity recorded from 34 participants overtly naming 134 images from 4 object categories (animals, tools, foods and clothes). Within each category, word length and phonological neighbourhood density were co-varied to target phonological/phonetic processes. Multivariate pattern analyses (MVPA) searchlights in source space decoded object categories in occipitotemporal and middle temporal cortex, and phonological/phonetic variables in left inferior frontal (BA 44) and motor cortex early on. The findings suggest early activation of multiple variables due to intercorrelated properties and interactivity of processing, thus raising important questions about the representational properties of target words during the preparatory time enabling overt speaking.

Abstract

Dyslexia is a highly heritable learning disorder with a complex underlying genetic architecture. Over the past decade, researchers have pinpointed a number of candidate genes that may contribute to dyslexia susceptibility. Here, we provide an overview of the state of the art, describing how studies have moved from mapping potential risk loci, through identification of associated gene variants, to characterization of gene function in cellular and animal model systems. Work thus far has highlighted some intriguing mechanistic pathways, such as neuronal migration, axon guidance, and ciliary biology, but it is clear that we still have much to learn about the molecular networks that are involved. We end the review by highlighting the past, present, and future contributions of the Dutch Dyslexia Programme to studies of genetic factors. In particular, we emphasize the importance of relating genetic information to intermediate neurobiological measures, as well as the value of incorporating longitudinal and developmental data into molecular designs

Abstract

According to theories of embodied cognition, understanding a verb like throw involves unconsciously simulating the action throwing, using areas of the brain that support motor planning. If understanding action words involves mentally simulating our own actions, then the neurocognitive representation of word meanings should differ for people with different kinds of bodies, who perform actions in systematically different ways. In a test of the body-specificity hypothesis (Casasanto, 2009), we used fMRI to compare premotor activity correlated with action verb understanding in right- and left-handers. Right-handers preferentially activated left premotor cortex during lexical decision on manual action verbs (compared with non-manual action verbs), whereas left-handers preferentially activated right premotor areas. This finding helps refine theories of embodied semantics, suggesting that implicit mental simulation during language processing is body-specific: Right and left-handers, who perform actions differently, use correspondingly different areas of the brain for representing action verb meanings.

Abstract

If concepts, categories, and word meanings are stable, how can people use them so flexibly? Here we explore a possible answer: maybe this stability is an illusion. Perhaps all concepts, categories, and word meanings (CC&Ms) are constructed ad hoc, each time we use them. On this proposal, all words are infinitely polysemous, all communication is ’good enough’, and no idea is ever the same twice. The details of people’s ad hoc CC&Ms are determined by the way retrieval cues interact with the physical, social, and linguistic context. We argue that even the most stable-seeming CC&Ms are instantiated via the same processes as those that are more obviously ad hoc, and vary (a) from one microsecond to the next within a given instantiation, (b) from one instantiation to the next within an individual, and (c) from person to person and group to group as a function of people’s experiential history. 826

Abstract

Do people with different kinds of bodies think differently? According to the body-specificity hypothesis, people who interact with their physical environments in systematically different ways should form correspondingly different mental representations. In a test of this hypothesis, 5 experiments investigated links between handedness and the mental representation of abstract concepts with positive or negative valence (e.g., honesty, sadness, intelligence). Mappings from spatial location to emotional valence differed between right- and left-handed participants. Right-handers tended to associate rightward space with positive ideas and leftward space with negative ideas, but left-handers showed the opposite pattern, associating rightward space with negative ideas and leftward with positive ideas. These contrasting mental metaphors for valence cannot be attributed to linguistic experience, because idioms in English associate good with right but not with left. Rather, right- and left-handers implicitly associated positive valence more strongly with the side of space on which they could act more fluently with their dominant hands. These results support the body-specificity hypothesis and provide evidence for the perceptuomotor basis of even the most abstract ideas.

Abstract

What is the relationship between motor action and emotion? Here we investigated whether people associate good things more strongly with the dominant side of their bodies, and bad things with the non-dominant side. To find out, we analyzed spontaneous gestures during speech expressing ideas with positive or negative emotional valence (e.g., freedom, pain, compassion). Samples of speech and gesture were drawn from the 2004 and 2008 US presidential debates, which involved two left-handers (Obama, McCain) and two right-handers (Kerry, Bush). Results showed a strong association between the valence of spoken clauses and the hands used to make spontaneous co-speech gestures. In right-handed candidates, right-hand gestures were more strongly associated with positive-valence clauses, and left-hand gestures with negative-valence clauses. Left-handed candidates showed the opposite pattern. Right- and left-handers implicitly associated positive valence more strongly with their dominant hand: the hand they can use more fluently. These results support the body-specificity hypothesis, (Casasanto, 2009), and suggest a perceptuomotor basis for even our most abstract ideas.

Abstract

Do people with different kinds of bodies think differently? According to the bodyspecificity hypothesis (Casasanto 2009), they should. In this article, I review evidence that right- and left-handers, who perform actions in systematically different ways, use correspondingly different areas of the brain for imagining actions and representing the meanings of action verbs. Beyond concrete actions, the way people use their hands also influences the way they represent abstract ideas with positive and negative emotional valence like “goodness,” “honesty,” and “intelligence,” and how they communicate about them in spontaneous speech and gesture. Changing how people use their right and left hands can cause them to think differently, suggesting that motoric differences between right- and left-handers are not merely correlated with cognitive differences. Body-specific patterns of motor experience shape the way we think, communicate, and make decisions

Abstract

What is the relationship between space and time in the human mind? Studies in adults show an asymmetric relationship between mental representations of these basic dimensions of experience: representations of time depend on space more than representations of space depend on time. Here we investigated the relationship between space and time in the developing mind. Native Greek-speaking children (N=99) watched movies of two animals traveling along parallel paths for different distances or durations and judged the spatial and temporal aspects of these events (e.g., Which animal went for a longer time, or a longer distance?) Results showed a reliable cross-dimensional asymmetry: for the same stimuli, spatial information influenced temporal judgments more than temporal information influenced spatial judgments. This pattern was robust to variations in the age of the participants and the type of language used to elicit responses. This finding demonstrates a continuity between space-time representations in children and adults, and informs theories of analog magnitude representation.

Abstract

Right- and left-handers implicitly associate positive ideas like "goodness"and "honesty"more strongly with their dominant side
of space, the side on which they can act more fluently, and negative ideas more strongly with their nondominant side. Here we show that right-handers’ tendency to associate "good" with "right" and "bad" with "left" can be reversed as a result of both
long- and short-term changes in motor fluency. Among patients who were right-handed prior to unilateral stroke, those with disabled left hands associated "good" with "right," but those with disabled right hands associated "good" with "left,"as natural left-handers do. A similar pattern was found in healthy right-handers whose right or left hand was temporarily handicapped in the laboratory. Even a few minutes of acting more fluently with the left hand can change right-handers’ implicit associations between space and emotional valence, causing a reversal of their usual judgments. Motor experience plays a causal role in shaping abstract thought.

Abstract

Can simple motor actions help people expand their vocabulary? Here we show that word learning depends on where students place their flash cards after studying them. In Experiment 1, participants learned the definitions of ”alien words” with positive or negative emotional valence. After studying each card, they placed it in one of two boxes (top or bottom), according to its valence. Participants who were instructed to place positive cards in the top box, consistent with Good is Up metaphors, scored about 10.

Abstract

When we think of children acquiring language, we often think of their acquisition of linguistic structure as separate from their acquisition of knowledge about the world. But it is clear that in the process of learning about language, children consult what they know about the world; and that in learning about the world, children use linguistic cues to discover how items are related to one another. This interaction between the acquisition of linguistic structure and the acquisition of category structure is especially clear in word learning.

Abstract

We investigate children’s online predictive processing as it occurs naturally, in conversation. We showed 1–7 year-olds short videos of improvised conversation between puppets, controlling for available linguistic information through phonetic manipulation. Even one- and two-year-old children made accurate and spontaneous predictions about when a turn-switch would occur: they gazed at the upcoming speaker before they heard a response begin. This predictive skill relies on both lexical and prosodic information together, and is not tied to either type of information alone. We suggest that children integrate prosodic, lexical, and visual information to effectively predict upcoming linguistic material in conversation.

Abstract

Background: Functional neuroimaging supports the hypothesis that auditory verbal hallucinations (AVH) in schizophrenia result from altered functional connectivity between perisylvian language regions, although the extent to which AVH are also associated with an altered tract anatomy is less clear.

Methods: Twenty-eight patients with schizophrenia subdivided into 17 subjects with a history of AVH and 11 without a history of hallucinations and 59 age- and IQ-matched healthy controls were recruited. The number of streamlines, fractional anisotropy (FA), and mean diffusivity were measured along the length of the arcuate fasciculus and its medial and lateral components.

Results: Patients with schizophrenia had bilateral reduction of FA relative to controls in the arcuate fasciculi (p < .001). Virtual dissection of the subcomponents of the arcuate fasciculi revealed that these reductions were specific to connections between posterior temporal and anterior regions in the inferior frontal and parietal lobe. Also, compared with controls, the reduction in FA of these tracts was highest, and bilateral, in patients with AVH, but in patients without AVH, this reduction was reported only on the left.

Conclusions: These findings point toward a supraregional network model of AVH in schizophrenia. They support the hypothesis that there may be selective vulnerability of specific anatomical connections to posterior temporal regions in schizophrenia and that extensive bilateral damage is associated with a greater vulnerability to AVH. If confirmed by further studies, these findings may advance our understanding of the anatomical factors that are protective against AVH and predictive of a treatment response.

Abstract

In this paper we explore the feasibility of artificial (formal) grammar recognition (AGR) using spiking neural networks. A biologically inspired minicolumn architecture is designed as the basic computational unit. A network topography is defined based on the minicolumn architecture, here referred to as nodes, connected with excitatory and inhibitory connections. Nodes in the network represent unique internal states of the grammar’s finite state machine (FSM). Future work to improve the performance of the networks is discussed. The modeling framework developed can be used by neurophysiological research to implement network layouts and compare simulated performance characteristics to actual subject performance.

Abstract

Eye gaze is a powerful ostensive cue in infant-caregiver interactions, with demonstrable effects on language acquisition. While the link between gaze following and later vocabulary is well-established, the effects of eye gaze on other aspects of language, such as speech processing, are less clear. In this EEG study, we examined the effects of the speaker’s eye gaze on ten-month-old infants’ neural tracking of naturalistic audiovisual speech, a marker for successful speech processing. Infants watched videos of a speaker telling stories, addressing the infant with direct or averted eye gaze. We assessed infants’ speech-brain coherence at stress (1–1.75 Hz) and syllable (2.5–3.5 Hz) rates, tested for differences in attention by comparing looking times and EEG theta power in the two conditions, and investigated whether neural tracking predicts later vocabulary. Our results showed that infants’ brains tracked the speech rhythm both at the stress and syllable rates, and that infants’ neural tracking at the syllable rate predicted later vocabulary. However, speech-brain coherence did not significantly differ between direct and averted gaze conditions and infants did not show greater attention to direct gaze. Overall, our results suggest significant neural tracking at ten months, related to vocabulary development, but not modulated by speaker’s gaze.

Abstract

Both children and adults predict the content of upcoming language, suggesting that prediction is useful for learning as well as processing. We present an alternative model which can explain prediction behaviour as a by-product of language learning. We suggest that a consideration of language acquisition places important constraints on Pickering & Garrod's (P&G's) theory.

Abstract

Tense/aspect morphology on verbs is often thought to depend on event features like telicity, but it is not known how speakers identify these features in visual scenes. To examine this question, we asked Japanese speakers to describe computer-generated animations of simple actions with variation in visual features related to telicity. Experiments with adults and children found that they could use goal information in the animations to select appropriate past and progressive verb forms. They also produced a large number of different verb forms. To explain these findings, a deep-learning model of verb production from visual input was created that could produce a human-like distribution of verb forms. It was able to use visual cues to select appropriate tense/aspect morphology. The model predicted that video duration would be related to verb complexity, and past tense production would increase when it received the endpoint as input. These predictions were confirmed in a third study with Japanese adults. This work suggests that verb production could be tightly linked to visual heuristics that support the understanding of events.

Abstract

Background: Eukaryotic cells possess a complex network of RNA machineries which function in RNA-processing and cellular regulation which includes transcription, translation, silencing, editing and epigenetic control. Studies of model organisms have shown that many ncRNAs of the RNA-infrastructure are highly conserved, but little is known from non-model protists. In this study we have conducted a genome-scale survey of medium-length ncRNAs from the protozoan parasites Giardia intestinalis and Trichomonas vaginalis. Results: We have identified the previously ‘missing’ Giardia RNase MRP RNA, which is a key ribozyme involved in pre-rRNA processing. We have also uncovered 18 new H/ACA box snoRNAs, expanding our knowledge of the H/ ACA family of snoRNAs. Conclusions: Results indicate that Giardia intestinalis and Trichomonas vaginalis, like their distant multicellular relatives, contain a rich infrastructure of RNA-based processing. From here we can investigate the evolution of RNA processing networks in eukaryotes.

Abstract

1 Introduction In spoken sentence processing, listeners do not wait till the end of a sentence to decipher what message is conveyed. Rather, they make predictions on the most plausible interpretation at every possible point in the auditory signal on the basis of all kinds of linguistic information (e.g., Eberhard et al. 1995; Alman and Kamide 1999, 2007). Intonation is one such kind of linguistic information that is efficiently used in spoken sentence processing. The evidence comes primarily from recent work on online reference resolution conducted in the visual-world eyetracking paradigm (e.g., Tanenhaus et al. 1995). In this paradigm, listeners are shown a visual scene containing a number of objects and listen to one or two short sentences about the scene. They are asked to either inspect the visual scene while listening or to carry out the action depicted in the sentence(s) (e.g., 'Touch the blue square'). Listeners' eye movements directed to each object in the scene are monitored and time-locked to pre-defined time points in the auditory stimulus. Their predictions on the upcoming referent and sources for the predictions in the auditory signal are examined by analysing fixations to the relevant objects in the visual scene before the acoustic information on the referent is available

Abstract

This study examines the perception of paralinguistic intonational meanings deriving from Ohala’s Frequency Code (Experiment 1) and Gussenhoven’s Effort Code (Experiment 2) in British English and Dutch. Native speakers of British English and Dutch listened to a number of stimuli in their native language and judged each stimulus on four semantic scales deriving from these two codes: SELF-CONFIDENT versus NOT SELF-CONFIDENT, FRIENDLY versus NOT FRIENDLY (Frequency Code); SURPRISED versus NOT SURPRISED, and EMPHATIC versus NOT EMPHATIC (Effort Code). The stimuli, which were lexically equivalent across the two languages, differed in pitch contour, pitch register and pitch span in Experiment 1, and in pitch register, peak height, peak alignment and end pitch in Experiment 2. Contrary to the traditional view that the paralinguistic usage of intonation is similar across languages, it was found that British English and Dutch listeners differed considerably in the perception of “confident,” “friendly,” “emphatic,” and “surprised.” The present findings support a theory of paralinguistic meaning based on the universality of biological codes, which however acknowledges a languagespecific component in the implementation of these codes.

Abstract

RNA interference (RNAi) is a set of mechanisms which regulate gene expression in eukaryotes. Key elements of RNAi are small sense and antisense RNAs from 19 to 26 nucleotides generated from double-stranded RNAs. miRNAs are a major type of RNAi-associated small RNAs and are found in most eukaryotes studied to date. To investigate whether small RNAs associated with RNAi appear to be present in all eukaryotic lineages, and therefore present in the ancestral eukaryote, we studied two deep-branching protozoan parasites, Giardia intestinalis and Trichomonas vaginalis. Little is known about endogenous small RNAs involved in RNAi of these organisms. Using Illumina Solexa sequencing and genome-wide analysis of small RNAs from these distantly related deep-branching eukaryotes, we identified 10 strong miRNA candidates from Giardia and 11 from Trichomonas. We also found evidence of Giardia siRNAs potentially involved in the expression of variant-specific-surface proteins. In addition, 8 new snoRNAs from Trichomonas are identified. Our results indicate that miRNAs are likely to be general in ancestral eukaryotes, and therefore are likely to be a universal feature of eukaryotes.

Abstract

This paper investigates L2 learners’ use of intonation in reference maintenance in comparison to native speakers at three longitudinal points. Nominal referring expressions were elicited from two untutored Turkish learners of Dutch and five native speakers of Dutch via a film retelling task, and were analysed in terms of pitch span and word duration. Effects of two types of change in information states were examined, between new and given and between new and accessible. We found native-like use of word duration in both types of change early on but different performances between learners and development over time in one learner in the use of pitch span. Further, the use of morphosyntactic devices had different effects on the two learners. The inter-learner differences and late systematic use of pitch span, in spite of similar use of pitch span in learners’ L1 and L2, suggest that learning may play a role in the acquisition of intonation as a device for reference maintenance.

Abstract

This paper gives an overview of recent studies on the use of phonological cues (accent placement and choice of accent type) to mark focus in Dutch-speaking children aged between 1;9 and 8;10. It is argued that learning to use phonological cues to mark focus is a gradual process. In the light of the findings in these studies, a first proposal is put forward on the developmental path to adult-like phonological focus-marking in Dutch.

Abstract

Pitch accents are analysed differently in an onramp analysis (i.e. ToBI) and an off-ramp analysis (e.g. Transcription of Dutch intonation - ToDI), two competing approaches in the Autosegmental Metrical tradition. A case in point is pre-final high rise. A pre-final rise is analysed as H* in ToBI but is phonologically ambiguous between H* or H*L (a (rise-)fall) in ToDI. This is because in ToDI, the L tone of a pre-final H*L can be realised in the following unaccented words and both H* and H*L can show up as a high rise in the accented word. To find out whether there is a two-way phonological contrast in pre-final high rises in Dutch, we examined the distribution of phonologically ambiguous high rises (H*(L)) and their phonetic realisation in different information structural conditions (topic vs. focus), compared to phonologically unambiguous H* and H*L. Results showed that there is indeed a H*L vs. H* contrast in prefinal high rises in Dutch and that H*L is realised as H*(L) when sonorant material is limited in the accented word. These findings provide new evidence for an off-ramp analysis of Dutch intonation and have far-reaching implications for analysis of intonation across languages.

Abstract

This study examined how four- to five-year-olds and seven- to eight-year-olds used intonation (accent placement and accent type) to encode topic and focus in Dutch. Naturally spoken declarative sentences with either sentence-initial topic and sentence-final focus or sentence-initial focus and sentence-final topic were elicited via a picture-matching game. Results showed that the four- to five-year-olds were adult-like in topic-marking, but were not yet fully adult-like in focus-marking, in particular, in the use of accent type in sentence-final focus (i.e. showing no preference for H*L). Between age five and seven, the use of accent type was further developed. In contrast to the four- to five-year-olds, the seven- to eight-year-olds showed a preference for H*L in sentence-final focus. Furthermore, they used accent type to distinguish sentence-initial focus from sentence-initial topic in addition to phonetic cues.

Abstract

The current study investigated how the role of pitch in one’s native language and L2 experience influenced musical melodic processing by testing Turkish and Mandarin Chinese advanced and beginning learners of English as an L2. Pitch has a lower functional load and shows a simpler pattern in Turkish than in Chinese as the former only contrasts between presence and the absence of pitch elevation, while the latter makes use of four different pitch contours lexically. Using the Musical Ear Test as the tool, we found that the Chinese listeners outperformed the Turkish listeners, and the advanced L2 learners outperformed the beginning learners. The Turkish listeners were further tested on their discrimination of bisyllabic Chinese lexical tones, and again an L2 advantage was observed. No significant difference was found for working memory between the beginning and advanced L2 learners. These results suggest that richness of tonal inventory of the native language is essential for triggering a music processing advantage, and on top of the tone language advantage, the L2 experience yields a further enhancement. Yet, unlike the tone language advantage that seems to relate to pitch expertise, learning an L2 seems to improve sound discrimination in general, and such improvement exhibits in non-native lexical tone discrimination.

Abstract

In this study, we analyze one French signing and one French speaking family’s interaction during dinner. The families composed of two parents and two children aged 3 to 11 were filmed with three cameras to capture all family members’ behaviors. The three videos per dinner were synchronized and coded on ELAN. We annotated all participants’ acting, and languaging.
Our quantitative analyses show how family members collaboratively manage multiple streams of activity through the embodied performances of dining and interacting. We uncover different profiles according to participants’ modality of expression and status (focusing on the mother and the younger child). The hearing participants’ co-activity management illustrates their monitoring of dining and conversing and how they progressively master the affordances of the visual and vocal channels to maintain the simultaneity of the two activities. The deaf mother skillfully manages to alternate smoothly between dining and interacting. The deaf younger child manifests how she is in the process of developing her skills to manage multi-activity. Our qualitative analyses focus on the ecology of visual-gestural and audio-vocal languaging in the context of co-activity according to language and participant. We open new perspectives on the management of gaze and body parts in multimodal languaging.

Abstract

We investigated how listeners of two unrelated languages, Dutch and Korean, process phonotactically legitimate and illegitimate sounds spoken in Dutch and American English. To Dutch listeners, unreleased word-final stops are phonotactically illegal because word-final stops in Dutch are generally released in isolation, but to Korean listeners, released final stops are illegal because word-final stops are never released in Korean. Two phoneme monitoring experiments showed a phonotactic effect: Dutch listeners detected released stops more rapidly than unreleased stops whereas the reverse was true for Korean listeners. Korean listeners with English stimuli detected released stops more accurately than unreleased stops, however, suggesting that acoustic-phonetic cues associated with released stops improve detection accuracy. We propose that in non-native speech perception, phonotactic legitimacy in the native language speeds up phoneme recognition, the richness of acousticphonetic cues improves listening accuracy, and familiarity with the non-native language modulates the relative influence of these two factors.

Abstract

The goal of this study is to examine how the degree of vowel-to-vowel coarticulation varies as a function of prosodic factors such as nuclear-pitch accent (accented vs. unaccented), level of prosodic boundary (Prosodic Word vs. Intermediate Phrase vs. Intonational Phrase), and position-in-prosodic-domain (initial vs. final). It is hypothesized that vowels in prosodically stronger locations (e.g., in accented syllables and at a higher prosodic boundary) are not only coarticulated less with their neighboring vowels, but they also exert a stronger influence on their neighbors. Measurements of tongue position for English /a i/ over time were obtained with Carsten’s electromagnetic articulography. Results showed that vowels in prosodically stronger locations are coarticulated less with neighboring vowels, but do not exert a stronger influence on the articulation of neighboring vowels. An examination of the relationship between coarticulation and duration revealed that (a) accent-induced coarticulatory variation cannot be attributed to a duration factor and (b) some of the data with respect to boundary effects may be accounted for by the duration factor. This suggests that to the extent that prosodically conditioned coarticulatory variation is duration-independent, there is no absolute causal relationship from duration to coarticulation. It is proposed that prosodically conditioned V-to-V coarticulatory reduction is another type of strengthening that occurs in prosodically strong locations. The prosodically driven coarticulatory patterning is taken to be part of the phonetic signatures of the hierarchically nested structure of prosody.

Abstract

The aim of this study was to determine if Dutch speakers reliably signal phrase-internal lexical boundaries, and if so, how. Six speakers recorded 4 pairs of phonemically identical strong-weak-strong (SWS) strings with matching syllable boundaries but mismatching intended word boundaries (e.g. reis # pastei versus reispas # tij, or more broadly C1V2(C)#C2V2(C)C3V3(C) vs. C1V2(C)C2V2(C)#C3V3(C)). An Analysis of Variance revealed 3 acoustic parameters that were significantly greater in S#WS items (C2 DURATION, RIME1 DURATION, C3 BURST AMPLITUDE) and 5 parameters that were significantly greater in the SW#S items (C2 VOT, C3 DURATION, RIME2 DURATION, RIME3 DURATION, and V2 AMPLITUDE). Additionally, center of gravity measurements suggested that the [s] to [t] coarticulation was greater in reis # pa[st]ei versus reispa[s] # [t]ij. Finally, a Logistic Regression Analysis revealed that the 3 parameters (RIME1 DURATION, RIME2 DURATION, and C3 DURATION) contributed most reliably to a S#WS versus SW#S classification.

Abstract

Two experiments examined whether perceptual recovery from Korean consonant-cluster simplification is based on language-specific phonological knowledge. In tri-consonantal C1C2C3 sequences such as /lkt/ and /lpt/ in Seoul Korean, either C1 or C2 can be completely deleted. Seoul Koreans monitored for C2 targets (/p/ or / k/, deleted or preserved) in the second word of a two-word phrase with an underlying /l/-C2-/t/ sequence. In Experiment 1 the target-bearing words had contextual lexical-semantic support. Listeners recovered deleted targets as fast and as accurately as preserved targets with both Word and Intonational Phrase (IP) boundaries between the two words. In Experiment 2, contexts were low-pass filtered. Listeners were still able to recover deleted targets as well as preserved targets in IP-boundary contexts, but better with physically-present targets than with deleted targets in Word-boundary contexts. This suggests that the benefit of having target acoustic-phonetic information emerges only when higher-order (contextual and phrase-boundary) information is not available. The strikingly efficient recovery of deleted phonemes with neither acoustic-phonetic cues nor contextual support demonstrates that language-specific phonological knowledge, rather than language-universal perceptual processes which rely on fine-grained phonetic details, is employed when the listener perceives the results of a continuous-speech process in which reduction is phonetically complete.

Abstract

English and Korean differ in how they lexicalize the components of motionevents. English characteristically conflates Motion with Manner, Cause, or Deixis, and expresses Path separately. Korean, in contrast, conflates Motion with Path and elements of Figure and Ground in transitive clauses for caused Motion, but conflates motion with Deixis and spells out Path and Manner separately in intransitive clauses for spontaneous motion. Children learningEnglish and Korean show sensitivity to language-specific patterns in the way they talk about motion from as early as 17–20 months. For example, learners of English quickly generalize their earliest spatial words — Path particles like up, down, and in — to both spontaneous and caused changes of location and, for up and down, to posture changes, while learners of Korean keep words for spontaneous and caused motion strictly separate and use different words for vertical changes of location and posture changes. These findings challenge the widespread view that children initially map spatial words directly to nonlinguistic spatial concepts, and suggest that they are influenced by the semantic organization of their language virtually from the beginning. We discuss how input and cognition may interact in the early phases of learning to talk about space.

Abstract

The fluent production of speech is a very complex human skill. It requires the coordination of several articulatory subsystems. The instructions that lead articulatory movements to execution are the result of the interplay of speech production levels that operate above the articulatory network. During the process of word-form encoding, the groundwork for the articulatory programs is prepared which then serve the articulators as basic units. This thesis investigated whether or not syllables form the basis for the articulatory programs and in particular whether or not these syllable programs are stored, separate from the store of the lexical word-forms. It is assumed that syllable units are stored in a so-called 'mental syllabary'. The main goal of this thesis was to find evidence of the syllable playing a functionally important role in speech production and for the assumption that syllables are stored units. In a variant of the implicit priming paradigm, it was investigated whether information about the syllabic structure of a target word facilitates the preparation (advanced planning) of a to-be-produced utterance. These experiments yielded evidence for the functionally important role of syllables in speech production. In a subsequent row of experiments, it could be demonstrated that the production of syllables is sensitive to frequency. Syllable frequency effects provide strong evidence for the notion of a mental syllabary because only stored units are likely to exhibit frequency effects. In a last study, effects of syllable preparation and syllable frequency were investigated in a combined study to disentangle the two effects. The results of this last experiment converged with those reported for the other experiments and added further support to the claim that syllables play a core functional role in speech production and are stored in a mental syllabary.

Abstract

Models of speech production assume that syllables play a functional role in the process of word-form encoding in speech production. In this study, we investigate this claim and specifically provide evidence about the level at which syllables come into play. We report two studies using an odd-man-out variant of the implicit priming paradigm to examine the role of the syllable during the process of word formation. Our results show that this modified version of the implicit priming paradigm can trace the emergence of syllabic structure during spoken word generation. Comparing these results to prior syllable priming studies, we conclude that syllables emerge at the interface between phonological and phonetic encoding. The results are discussed in terms of the WEAVER++ model of lexical access.

Abstract

In the current paper, we asked at what level in the speech planning process speakers retrieve stored syllables. There is evidence that syllable structure plays an essential role in the phonological encoding of words (e.g., online syllabification and phonological word formation). There is also evidence that syllables are retrieved as whole units. However, findings that clearly pinpoint these effects to specific levels in speech planning are scarce. We used a naming variant of the implicit priming paradigm to contrast voice onset latencies for frequency-manipulated disyllabic Dutch pseudo-words. While prior implicit priming studies only manipulated the item's form and/or syllable structure overlap we introduced syllable frequency as an additional factor. If the preparation effect for syllables obtained in the implicit priming paradigm proceeds beyond phonological planning, i.e., includes the retrieval of stored syllables, then the preparation effect should differ for high- and low frequency syllables. The findings reported here confirm this prediction: Low-frequency syllables benefit significantly more from the preparation than high-frequency syllables. Our findings support the notion of a mental syllabary at a post-lexical level, between the levels of phonological and phonetic encoding.

Abstract

We investigated the role of syllables during speech planning in English by measuring syllable-frequency effects. So far, syllable-frequency effects in English have not been reported. English has poorly defined syllable boundaries, and thus the syllable might not function as a prominent unit in English speech production. Speakers produced either monosyllabic (Experiment 1) or disyllabic (Experiment 2–4) pseudowords as quickly as possible in response to symbolic cues. Monosyllabic targets consisted of either high- or low-frequency syllables, whereas disyllabic items contained either a 1st or 2nd syllable that was frequency-manipulated. Significant syllable-frequency effects were found in all experiments. Whereas previous findings for disyllables in Dutch and Spanish—languages with relatively clear syllable boundaries—showed effects of a frequency manipulation on 1st but not 2nd syllables, in our study English speakers were sensitive to the frequency of both syllables. We interpret this sensitivity as an indication that the production of English has more extensive planning scopes at the interface of phonetic encoding and articulation.

Abstract

Although most bilinguals can translate with relative ease, the underlying neuro-cognitive processes are poorly understood. Using event-related brain potentials (ERPs) we investigated the temporal course of word translation. Participants translated words from and to their first (L1, Dutch) and second (L2, English) language while ERPs were recorded. Interlingual homographs (IHs) were included to introduce language conflict. IHs share orthographic form but have different meanings in L1 and L2 (e.g., room in Dutch refers to cream). Results showed that the brain distinguished between translation directions as early as 200 ms after word presentation: the P2 amplitudes were more positive in the L1L2 translation direction. The N400 was also modulated by translation direction, with more negative amplitudes in the L2L1 translation direction. Furthermore, the IHs were translated more slowly, induced more errors, and elicited more negative N400 amplitudes than control words. In a naming experiment, participants read aloud the same words in L1 or L2 while ERPs were recorded. Results showed no effect of either IHs or language, suggesting that task schemas may be crucially related to language control in translation. Furthermore, translation appears to involve conceptual processing in both translation directions, and the task goal appears to influence how words are processed.

Abstract

When we speak, we spontaneously produce gestures (co-speech gestures). Co-speech gestures and speech production are closely interlinked. However, the exact nature of the link is still under debate. To addressed the question that whether co-speech gestures originate from the speech production system or from a system independent of the speech production, the present study examined the relationship between co-speech and co-thought gestures. Co-thought gestures, produced during silent thinking without speaking, presumably originate from a system independent of the speech production processes. We found a positive correlation between the production frequency of co-thought and co-speech gestures, regardless the communicative function that co-speech gestures might serve. Therefore, we suggest that co-speech gestures and co-thought gestures originate from a common system that is independent of the speech production processes

Abstract

People spontaneously produce gestures when they solve problems or explain their solutions to a problem. In this chapter, we will review and discuss evidence on the role of representational gestures in problem solving. The focus will be on our recent experiments (Chu & Kita, 2008), in which we used Shepard-Metzler type of mental rotation tasks to investigate how spontaneous gestures revealed the development of problem solving strategy over the course of the experiment and what role gesture played in the development process. We found that when solving novel problems regarding the physical world, adults go through similar symbolic distancing (Werner & Kaplan, 1963) and internalization (Piaget, 1968) processes as those that occur during young children’s cognitive development and gesture facilitates such processes.

Abstract

Co-thought gestures are hand movements produced in silent, noncommunicative, problem-solving situations. In the study, we investigated whether and how such gestures enhance performance in spatial visualization tasks such as a mental rotation task and a paper folding task. We found that participants gestured more often when they had difficulties solving mental rotation problems Experiment 1). The gesture-encouraged group solved more mental rotation problems correctly than did the gesture-allowed and gesture-prohibited groups (Experiment 2). Gestures produced by the gesture-encouraged group enhanced performance in the very trials in which they were produced Experiments 2 & 3). Furthermore, gesture frequency decreased as the participants in the gesture-encouraged group solved more problems (Experiments 2 & 3). In addition, the advantage of the gesture-encouraged group persisted into subsequent spatial visualization problems in which gesturing was prohibited: another mental rotation block (Experiment 2) and a newly introduced paper folding task (Experiment 3). The results indicate that when people have difficulty in solving spatial visualization problems, they spontaneously produce gestures to help them, and gestures can indeed improve performance. As they solve more problems, the spatial computation supported by gestures becomes internalized, and the gesture frequency decreases. The benefit of gestures persists even in subsequent spatial visualization problems in which gesture is prohibited. Moreover, the beneficial effect of gesturing can be generalized to a different spatial visualization task when two tasks require similar spatial transformation processes. We conclude that gestures enhance performance on spatial visualization tasks by improving the internal computation of spatial transformations.

Abstract

Methods
The present study provides a systematic analysis of co-speech gestures which spontaneously accompany the description of actions in a group of PD patients (N = 23, Hoehn and Yahr Stage III or less) and age-matched healthy controls (N = 22). The analysis considers different co-speech gesture types, using established classification schemes from the field of gesture research. The analysis focuses on the rate of these gestures as well as on their qualitative nature. In doing so, the analysis attempts to overcome several methodological shortcomings of research in this area.
Results
Contrary to expectation, gesture rate was not significantly affected in our patient group, with relatively mild PD. This indicates that co-speech gestures could compensate for speech problems. However, while gesture rate seems unaffected, the qualitative precision of gestures representing actions was significantly reduced.
Conclusions
This study demonstrates the feasibility of carrying out fine-grained, detailed analyses of gestures in PD and offers insights into an as yet neglected facet of communication in patients with PD. Based on the present findings, an important next step is the closer investigation of the qualitative changes in gesture (including different communicative situations) and an analysis of the heterogeneity in co-speech gesture production in PD.

Abstract

In this chapter, we survey the processes of recognizing and producing words and of understanding and creating sentences. Theory and research on these topics have been shaped by debates about how various sources of information are integrated in these processes, and about the role of language structure, as analyzed in the discipline of linguistics. In this chapter, we describe current views of fluent language users' comprehension of spoken and written language and their production of spoken language. We review what we consider to be the most important findings and theories in psycholinguistics, returning again and again to the questions of modularity and the importance of linguistic knowledge. Although we acknowledge the importance of social factors in language use, our focus is on core processes such as parsing and word retrieval that are not necessarily affected by such factors. We do not have space to say much about the important fields of developmental psycholinguistics, which deals with the acquisition of language by children, or applied psycholinguistics, which encompasses such topics as language disorders and language teaching. Although we recognize that there is burgeoning interest in the measurement of brain activity during language processing and how language is represented in the brain, space permits only occasional pointers to work in neuropsychology and the cognitive neuroscience of language. For treatment of these topics, and others, the interested reader could begin with two recent handbooks of psycholinguistics (Gaskell, 2007; Traxler & Gemsbacher, 2006) and a handbook of cognitive neuroscience (Gazzaniga, 2004).

Abstract

Background. Facial emotion recognition deficits are common after moderate-severe traumatic brain injury (TBI) and linked to poor social outcomes. We examine whether emotion recognition deficits extend to facial expressions depicted by emoji.
Methods. Fifty-one individuals with moderate-severe TBI (25 female) and fifty-one neurotypical peers (26 female) viewed photos of human faces and emoji. Participants selected the best-fitting label from a set of basic emotions (anger, disgust, fear, sadness, neutral, surprise, happy) or social emotions (embarrassed, remorseful, anxious, neutral, flirting, confident, proud).
Results. We analyzed the likelihood of correctly labeling an emotion by group (neurotypical, TBI), stimulus condition (basic faces, basic emoji, social emoji), sex (female, male), and their interactions. Participants with TBI did not significantly differ from neurotypical peers in overall emotion labeling accuracy. Both groups had poorer labeling accuracy for emoji compared to faces. Participants with TBI (but not neurotypical peers) had poorer accuracy for labeling social emotions depicted by emoji compared to basic emotions depicted by emoji. There were no effects of participant sex.
Discussion. Because emotion representation is more ambiguous in emoji than human faces, studying emoji use and perception in TBI is an important consideration for understanding functional communication and social participation after brain injury.

Abstract

Purpose

Real-world communication is situated in rich multimodal contexts, containing speech and gesture. Speakers often convey unique information in gesture that is not present in the speech signal (e.g., saying “He searched for a new recipe” while making a typing gesture). We examine the narrative retellings of participants with and without moderate-severe traumatic brain injury across three timepoints over two online Zoom sessions to investigate whether people with TBI can integrate information from co-occurring speech and gesture and if information from gesture persists across delays.

Methods

60 participants with TBI and 60 non-injured peers watched videos of a narrator telling four short stories. On key details, the narrator produced complementary gestures that conveyed unique information. Participants retold the stories at three timepoints: immediately after, 20-min later, and one-week later. We examined the words participants used when retelling these key details, coding them as a Speech Match (e.g., “He searched for a new recipe”), a Gesture Match (e.g., “He searched for a new recipe online), or Other (“He looked for a new recipe”). We also examined whether participants produced representative gestures themselves when retelling these details.

Results

Despite recalling fewer story details, participants with TBI were as likely as non-injured peers to report information from gesture in their narrative retellings. All participants were more likely to report information from gesture and produce representative gestures themselves one-week later compared to immediately after hearing the story.

Conclusion

We demonstrated that speech-gesture integration is intact after TBI in narrative retellings. This finding has exciting implications for the utility of gesture to support comprehension and memory after TBI and expands our understanding of naturalistic multimodal language processing in this population.

Abstract

Impaired facial affect recognition is common after traumatic brain injury (TBI) and linked to poor social outcomes. We explored whether perception of emotions depicted by emoji is also impaired after TBI. Fifty participants with TBI and 50 non-injured peers generated free-text labels to describe emotions depicted by emoji and rated their levels of valence and arousal on nine-point rating scales. We compared how the two groups’ valence and arousal ratings were clustered and examined agreement in the words participants used to describe emoji. Hierarchical clustering of affect ratings produced four emoji clusters in the non-injured group and three emoji clusters in the TBI group. Whereas the non-injured group had a strongly positive and a moderately positive cluster, the TBI group had a single positive valence cluster, undifferentiated by arousal. Despite differences in cluster numbers, hierarchical structures of the two groups’ emoji ratings were significantly correlated. Most emoji had high agreement in the words participants with and without TBI used to describe them. Participants with TBI perceived emoji similarly to non-injured peers, used similar words to describe emoji, and rated emoji similarly on the valence dimension. Individuals with TBI showed small differences in perceived arousal for a minority of emoji. Overall, results suggest that basic recognition processes do not explain challenges in computer-mediated communication reported by adults with TBI. Examining perception of emoji in context by people with TBI is an essential next step for advancing our understanding of functional communication in computer-mediated contexts after brain injury.

Abstract

We report the results of a cross-cultural investigation of person-body reasoning in the United Kingdom and northern Brazilian Amazon (Marajo´ Island). The study provides evidence that directly bears upon divergent theoretical claims in cognitive psychology and anthropology, respectively, on the cognitive origins and cross-cultural incidence of mind-body dualism. In a novel reasoning task, we found that participants across the two sample populations parsed a wide range of capacities similarly in terms of the capacities’ perceived anchoring to bodily function. Patterns of reasoning concerning the respective roles of physical and biological properties in sustaining various capacities did vary between sample populations, however. Further, the data challenge prior ad-hoc categorizations in the empirical literature on the developmental origins of and cognitive constraints on psycho-physical reasoning (e.g., in afterlife concepts). We suggest cross-culturally validated categories of ‘‘Body Dependent’’ and ‘‘Body Independent’’ items for future developmental and cross-cultural research in this emerging area.

Abstract

Recent theoretical models have demonstrated that phenotypic traits can support the non-random assortment of cooperators in a population, thereby permitting the evolution of cooperation. In these “tag-based models”, cooperators modulate cooperation according to an observable and hard-to-fake trait displayed by potential interaction partners. Socially acquired vocalizations in general, and speech accent among humans in particular, are frequently proposed as hard to fake and hard to hide traits that display sufficient cross-populational variability to reliably guide such social assortment in fission–fusion societies. Adults’ sensitivity to accent variation in social evaluation and decisions about cooperation is well-established in sociolinguistic research. The evolutionary and developmental origins of these biases are largely unknown, however. Here, we investigate the influence of speech accent on 5–10-year-old children's developing social and cooperative preferences across four Brazilian Amazonian towns. Two sites have a single dominant accent, and two sites have multiple co-existing accent varieties. We found that children's friendship and resource allocation preferences were guided by accent only in sites characterized by accent heterogeneity. Results further suggest that this may be due to a more sensitively tuned ear for accent variation. The demonstrated local-accent preference did not hold in the face of personal cost. Results suggest that mechanisms guiding tag-based assortment are likely tuned according to locally relevant tag-variation.

Abstract

Our knowledge of RNA biology within eukaryotes has exploded over the last five years. Within new research we see that some features that were once thought to be part of multicellular life have now been identified in several protist lineages. Hence, it is timely to ask which features of eukaryote RNA biology are ancestral to all eukaryotes. We focus on RNA-based regulation and epigenetic mechanisms that use small regulatory ncRNAs and long ncRNAs, to highlight some of the many questions surrounding eukaryotic ncRNA evolution.

Abstract

Summary Non-coding RNAs (ncRNAs) have been implicated in the epigenetic marking of many genes. Short regulatory ncRNAs, including miRNAs, siRNAs, piRNAs and snoRNAs as well as long ncRNAs such as Xist and Air are discussed in light of recent research of mechanisms regulating chromatin marking and RNA editing. The topic is expanding rapidly so we will concentrate on examples to highlight the main mechanisms, including simple mechanisms where complementary binding affect methylation or RNA sites. However, other examples especially with the long ncRNAs highlight very complex regulatory systems with multiple layers of ncRNA control.

Abstract

The nature of the connection between musical and spatial processing is controversial. While pitch may be described in spatial terms such as “high” or “low”, it is unclear whether pitch and space are associated but separate dimensions or whether they share representational and processing resources. In the present study, we asked participants to judge whether a target vocal note was the same as (or different from) a preceding cue note. Importantly, target trials were presented as video clips where a singer sometimes gestured upward or downward while singing that target note, thus providing an alternative, concurrent source of spatial information. Our results show that pitch discrimination was significantly biased by the spatial movement in gesture, such that downward gestures made notes seem lower in pitch than they really were, and upward gestures made notes seem higher in pitch. These effects were eliminated by spatial memory load but preserved under verbal memory load conditions. Together, our findings suggest that pitch and space have a shared representation such that the mental representation of pitch is audiospatial in nature.

Abstract

We report an investigation of the perception of American English phonemes by Dutch listeners proficient in English. Listeners identified either the consonant or the vowel in most possible English CV and VC syllables. The syllables were embedded in multispeaker babble at three signal-to-noise ratios (16 dB, 8 dB, and 0 dB). Effects of signal-to-noise ratio on vowel and consonant identification are discussed as a function of syllable position and of relationship to the native phoneme inventory. Comparison of the results with previously reported data from native listeners reveals that noise affected the responding of native and non-native listeners similarly.

Abstract

Previous electroencephalography studies have yielded evidence for automatic processing of syntax and lexical stress. However, these studies looked at both effects in isolation, limiting their generalizability to everyday language comprehension. In the current study, we investigated automatic processing of grammatical agreement in the face of variation in lexical stress. Using an oddball paradigm, we measured the Mismatch Negativity (MMN) in Dutch-speaking participants while they listened to Dutch subject–verb sequences (linguistic context) or acoustically similar sequences in which the subject was replaced by filtered noise (nonlinguistic context). The verb forms differed in the inflectional suffix, rendering the subject–verb sequences grammatically correct or incorrect, and leading to a difference in the stress pattern of the verb forms. We found that the MMNs were modulated in both the linguistic and nonlinguistic condition, suggesting that the processing load induced by variation in lexical stress can hinder early automatic processing of grammatical agreement. However, as the morphological differences between the verb forms correlated with differences in number of syllables, an interpretation in terms of the prosodic structure of the sequences cannot be ruled out. Future research is needed to determine which of these factors (i.e., lexical stress, syllabic structure) most strongly modulate early syntactic processing.