Publications

Displaying 201 - 300 of 587
  • Gebre, B. G., Crasborn, O., Wittenburg, P., Drude, S., & Heskes, T. (2014). Unsupervised feature learning for visual sign language identification. In Proceedings of the 52nd Annual Meeting of the Association for Computational Linguistics: Vol 2 (pp. 370-376). Redhook, NY: Curran Proceedings.

    Abstract

    Prior research on language identification focused primarily on text and speech. In this paper, we focus on the visual modality and present a method for identifying sign languages solely from short video samples. The method is trained on unlabelled video data (unsupervised feature learning) and using these features, it is trained to discriminate between six sign languages (supervised learning). We ran experiments on video samples involving 30 signers (running for a total of 6 hours). Using leave-one-signer-out cross-validation, our evaluation on short video samples shows an average best accuracy of 84%. Given that sign languages are under-resourced, unsupervised feature learning techniques are the right tools and our results indicate that this is realistic for sign language identification.
  • Gentzsch, W., Lecarpentier, D., & Wittenburg, P. (2014). Big data in science and the EUDAT project. In Proceeding of the 2014 Annual SRII Global Conference.
  • Goudbeek, M., Smits, R., Cutler, A., & Swingley, D. (2005). Acquiring auditory and phonetic categories. In H. Cohen, & C. Lefebvre (Eds.), Handbook of categorization in cognitive science (pp. 497-513). Amsterdam: Elsevier.
  • Goudbeek, M., & Broersma, M. (2010). The Demo/Kemo corpus: A principled approach to the study of cross-cultural differences in the vocal expression and perception of emotion. In Proceedings of the Seventh International Conference on Language Resources and Evaluation (LREC 2010) (pp. 2211-2215). Paris: ELRA.

    Abstract

    This paper presents the Demo / Kemo corpus of Dutch and Korean emotional speech. The corpus has been specifically developed for the purpose of cross-linguistic comparison, and is more balanced than any similar corpus available so far: a) it contains expressions by both Dutch and Korean actors as well as judgments by both Dutch and Korean listeners; b) the same elicitation technique and recording procedure was used for recordings of both languages; c) the same nonsense sentence, which was constructed to be permissible in both languages, was used for recordings of both languages; and d) the emotions present in the corpus are balanced in terms of valence, arousal, and dominance. The corpus contains a comparatively large number of emotions (eight) uttered by a large number of speakers (eight Dutch and eight Korean). The counterbalanced nature of the corpus will enable a stricter investigation of language-specific versus universal aspects of emotional expression than was possible so far. Furthermore, given the carefully controlled phonetic content of the expressions, it allows for analysis of the role of specific phonetic features in emotional expression in Dutch and Korean.
  • Gubian, M., Bergmann, C., & Boves, L. (2010). Investigating word learning processes in an artificial agent. In Proceedings of the IXth IEEE International Conference on Development and Learning (ICDL). Ann Arbor, MI, 18-21 Aug. 2010 (pp. 178 -184). IEEE.

    Abstract

    Researchers in human language processing and acquisition are making an increasing use of computational models. Computer simulations provide a valuable platform to reproduce hypothesised learning mechanisms that are otherwise very difficult, if not impossible, to verify on human subjects. However, computational models come with problems and risks. It is difficult to (automatically) extract essential information about the developing internal representations from a set of simulation runs, and often researchers limit themselves to analysing learning curves based on empirical recognition accuracy through time. The associated risk is to erroneously deem a specific learning behaviour as generalisable to human learners, while it could also be a mere consequence (artifact) of the implementation of the artificial learner or of the input coding scheme. In this paper a set of simulation runs taken from the ACORNS project is investigated. First a look `inside the box' of the learner is provided by employing novel quantitative methods for analysing changing structures in large data sets. Then, the obtained findings are discussed in the perspective of their ecological validity in the field of child language acquisition.
  • Guerra, E., Huettig, F., & Knoeferle, P. (2014). Assessing the time course of the influence of featural, distributional and spatial representations during reading. In P. Bello, M. Guarini, M. McShane, & B. Scassellati (Eds.), Proceedings of the 36th Annual Meeting of the Cognitive Science Society (CogSci 2014) (pp. 2309-2314). Austin, TX: Cognitive Science Society. Retrieved from https://mindmodeling.org/cogsci2014/papers/402/.

    Abstract

    What does semantic similarity between two concepts mean? How could we measure it? The way in which semantic similarity is calculated might differ depending on the theoretical notion of semantic representation. In an eye-tracking reading experiment, we investigated whether two widely used semantic similarity measures (based on featural or distributional representations) have distinctive effects on sentence reading times. In other words, we explored whether these measures of semantic similarity differ qualitatively. In addition, we examined whether visually perceived spatial distance interacts with either or both of these measures. Our results showed that the effect of featural and distributional representations on reading times can differ both in direction and in its time course. Moreover, both featural and distributional information interacted with spatial distance, yet in different sentence regions and reading measures. We conclude that featural and distributional representations are distinct components of semantic representation.
  • Guerra, E., & Knoeferle, P. (2014). Spatial distance modulates reading times for sentences about social relations: evidence from eye tracking. In P. Bello, M. Guarini, M. McShane, & B. Scassellati (Eds.), Proceedings of the 36th Annual Meeting of the Cognitive Science Society (CogSci 2014) (pp. 2315-2320). Austin, TX: Cognitive Science Society. Retrieved from https://mindmodeling.org/cogsci2014/papers/403/.

    Abstract

    Recent evidence from eye tracking during reading showed that non-referential spatial distance presented in a visual context can modulate semantic interpretation of similarity relations rapidly and incrementally. In two eye-tracking reading experiments we extended these findings in two important ways; first, we examined whether other semantic domains (social relations) could also be rapidly influenced by spatial distance during sentence comprehension. Second, we aimed to further specify how abstract language is co-indexed with spatial information by varying the syntactic structure of sentences between experiments. Spatial distance rapidly modulated reading times as a function of the social relation expressed by a sentence. Moreover, our findings suggest that abstract language can be co-indexed as soon as critical information becomes available for the reader.
  • Gullberg, M., Roberts, L., Dimroth, C., Veroude, K., & Indefrey, P. (2010). Adult language learning after minimal exposure to an unknown natural language. In M. Gullberg, & P. Indefrey (Eds.), The earliest stages of language learning (pp. 5-24). Malden, MA: Wiley-Blackwell.
  • Gullberg, M., De Bot, K., & Volterra, V. (2010). Gestures and some key issues in the study of language development. In M. Gullberg, & K. De Bot (Eds.), Gestures in language development (pp. 3-33). Amsterdam: Benjamins.
  • Gullberg, M., & Indefrey, P. (Eds.). (2010). The earliest stages of language learning [Special Issue]. Language Learning, 60(Supplement s2).
  • De Haan, E., & Hagoort, P. (2004). Het brein in beeld. In B. Deelman, P. Eling, E. De Haan, & E. Van Zomeren (Eds.), Klinische neuropsychologie (pp. 82-98). Amsterdam: Boom.
  • Hagoort, P. (2004). Er is geen behoefte aan trompetten als gordijnen. In H. Procee, H. Meijer, P. Timmerman, & R. Tuinsma (Eds.), Bij die wereld wil ik horen! Zesendertig columns en drie essays over de vorming tot academicus (pp. 78-80). Amsterdam: Boom.
  • Hagoort, P. (2005). Breintaal. In S. Knols, & D. Redeker (Eds.), NWO-Spinozapremies 2005 (pp. 21-34). Den Haag: NWO.
  • Hagoort, P. (2005). Broca's complex as the unification space for language. In A. Cutler (Ed.), Twenty-first century psycholinguistics: Four cornerstones (pp. 157-173). Mahwah, NJ: Erlbaum.
  • Hagoort, P. (2004). Het zwarte gat tussen brein en bewustzijn. In N. Korteweg (Ed.), De oorsprong: Over het ontstaan van het leven en alles eromheen (pp. 107-124). Amsterdam: Boom.
  • Hagoort, P. (2014). Introduction to section on language and abstract thought. In M. S. Gazzaniga, & G. R. Mangun (Eds.), The cognitive neurosciences (5th ed., pp. 615-618). Cambridge, Mass: MIT Press.
  • Hagoort, P., & Levinson, S. C. (2014). Neuropragmatics. In M. S. Gazzaniga, & G. R. Mangun (Eds.), The cognitive neurosciences (5th ed., pp. 667-674). Cambridge, Mass: MIT Press.
  • Hagoort, P., Brown, C. M., & Osterhout, L. (1999). The neurocognition of syntactic processing. In C. M. Brown, & P. Hagoort (Eds.), The neurocognition of language (pp. 273-317). Oxford: Oxford University Press.
  • Hagoort, P. (1999). The uniquely human capacity for language communication: from 'pope' to [po:p] in half a second. In J. Russell, M. Murphy, T. Meyering, & M. Arbib (Eds.), Neuroscience and the person: Scientific perspectives on divine action (pp. 45-56). California: Berkeley.
  • Hamans, C., & Seuren, P. A. M. (2010). Chomsky in search of a pedigree. In D. A. Kibbee (Ed.), Chomskyan (R)evolutions (pp. 377-394). Amsterdam/Philadelphia: Benjamins.

    Abstract

    This paper follows the changing fortunes of Chomsky’s search for a pedigree in the history of Western thought during the late 1960s. Having achieved a unique position of supremacy in the theory of syntax and having exploited that position far beyond the narrow circles of professional syntacticians, he felt the need to shore up his theory with the authority of history. It is shown that this attempt, resulting mainly in his Cartesian Linguistics of 1966, was widely, and rightly, judged to be a radical failure, even though it led to a sudden revival of interest in the history of linguistics. Ironically, the very upswing in historical studies caused by Cartesian Linguistics ended up showing that the real pedigree belongs to Generative Semantics, developed by the same ‘angry young men’ Chomsky was so bent on destroying.
  • Hammarström, H. (2014). Basic vocabulary comparison in South American languages. In P. Muysken, & L. O'Connor (Eds.), Language contact in South America (pp. 56-72). Cambridge: Cambridge University Press.
  • Hammarström, H. (2014). Papuan languages. In M. Aronoff (Ed.), Oxford bibliographies in linguistics. New York: Oxford University Press. doi:10.1093/OBO/9780199772810-0165.
  • Hammarström, H. (2010). Rarities in numeral systems. In J. Wohlgemuth, & M. Cysouw (Eds.), Rethinking universals. How rarities affect linguistic theory (pp. 11-60). Berlin: De Gruyter.
  • Hammond, J. (2014). Switch-reference antecedence and subordination in Whitesands (Oceanic). In R. van Gijn, J. Hammond, D. Matić, S. van Putten, & A. V. Galucio (Eds.), Information structure and reference tracking in complex sentences. (pp. 263-290). Amsterdam: Benjamins.

    Abstract

    Whitesands is an Oceanic language of the southern Vanuatu subgroup. Like the related languages of southern Vanuatu, Whitesands has developed a clause-linkage system which monitors referent continuity on new clauses – typically contrasting with the previous clause. In this chapter I address how the construction interacts with topic continuity in discourse. I outline the morphosyntactic form of this anaphoric co-reference device. From a functionalist perspective, I show how the system is used in natural discourse and discuss its restrictions with respect to relative and complement clauses. I conclude with a discussion on its interactions with theoretical notions of information structure – in particular the nature of presupposed versus asserted clauses, information back- and foregrounding and how these affect the use of the switch-reference system
  • Hanique, I., Schuppler, B., & Ernestus, M. (2010). Morphological and predictability effects on schwa reduction: The case of Dutch word-initial syllables. In Proceedings of the 11th Annual Conference of the International Speech Communication Association (Interspeech 2010), Makuhari, Japan (pp. 933-936).

    Abstract

    This corpus-based study shows that the presence and duration of schwa in Dutch word-initial syllables are affected by a word’s predictability and its morphological structure. Schwa is less reduced in words that are more predictable given the following word. In addition, schwa may be longer if the syllable forms a prefix, and in prefixes the duration of schwa is positively correlated with the frequency of the word relative to its stem. Our results suggest that the conditions which favor reduced realizations are more complex than one would expect on the basis of the current literature.
  • Hanulikova, A., & Weber, A. (2010). Production of English interdental fricatives by Dutch, German, and English speakers. In K. Dziubalska-Kołaczyk, M. Wrembel, & M. Kul (Eds.), Proceedings of the 6th International Symposium on the Acquisition of Second Language Speech, New Sounds 2010, Poznań, Poland, 1-3 May 2010 (pp. 173-178). Poznan: Adam Mickiewicz University.

    Abstract

    Non-native (L2) speakers of English often experience difficulties in producing English interdental fricatives (e.g. the voiceless [θ]), and this leads to frequent substitutions of these fricatives (e.g. with [t], [s], and [f]). Differences in the choice of [θ]-substitutions across L2 speakers with different native (L1) language backgrounds have been extensively explored. However, even within one foreign accent, more than one substitution choice occurs, but this has been less systematically studied. Furthermore, little is known about whether the substitutions of voiceless [θ] are phonetically clear instances of [t], [s], and [f], as they are often labelled. In this study, we attempted a phonetic approach to examine language-specific preferences for [θ]-substitutions by carrying out acoustic measurements of L1 and L2 realizations of these sounds. To this end, we collected a corpus of spoken English with L1 speakers (UK-English), and Dutch and German L2 speakers. We show a) that the distribution of differential substitutions using identical materials differs between Dutch and German L2 speakers, b) that [t,s,f]-substitutes differ acoustically from intended [t,s,f], and c) that L2 productions of [θ] are acoustically comparable to L1 productions.
  • Heeschen, V., Eibl-Eibesfeldt, I., Grammer, K., Schiefenhövel, W., & Senft, G. (1986). Sprachliches Verhalten. In Generalverwaltung der MPG (Ed.), Max-Planck-Gesellschaft Jahrbuch 1986 (pp. 394-396). Göttingen: Vandenhoeck and Ruprecht.
  • Heyselaar, E., Hagoort, P., & Segaert, K. (2014). In dialogue with an avatar, syntax production is identical compared to dialogue with a human partner. In P. Bello, M. Guarini, M. McShane, & B. Scassellati (Eds.), Proceedings of the 36th Annual Meeting of the Cognitive Science Society (CogSci 2014) (pp. 2351-2356). Austin, Tx: Cognitive Science Society.

    Abstract

    The use of virtual reality (VR) as a methodological tool is
    becoming increasingly popular in behavioural research due
    to its seemingly limitless possibilities. This new method has
    not been used frequently in the field of psycholinguistics,
    however, possibly due to the assumption that humancomputer
    interaction does not accurately reflect human-human
    interaction. In the current study we compare participants’
    language behaviour in a syntactic priming task with human
    versus avatar partners. Our study shows comparable priming
    effects between human and avatar partners (Human: 12.3%;
    Avatar: 12.6% for passive sentences) suggesting that VR is a
    valid platform for conducting language research and studying
    dialogue interactions.
  • Hill, C. (2010). Emergency language documentation teams: The Cape York Peninsula experience. In J. Hobson, K. Lowe, S. Poetsch, & M. Walsh (Eds.), Re-awakening languages: Theory and practice in the revitalisation of Australia’s Indigenous languages (pp. 418-432). Sydney: Sydney University Press.
  • Hoffmann, C. W. G., Sadakata, M., Chen, A., Desain, P., & McQueen, J. M. (2014). Within-category variance and lexical tone discrimination in native and non-native speakers. In C. Gussenhoven, Y. Chen, & D. Dediu (Eds.), Proceedings of the 4th International Symposium on Tonal Aspects of Language (pp. 45-49). Nijmegen: Radboud University Nijmegen.

    Abstract

    In this paper, we show how acoustic variance within lexical tones in disyllabic Mandarin Chinese pseudowords affects discrimination abilities in both native and non-native speakers of Mandarin Chinese. Within-category acoustic variance did not hinder native speakers in discriminating between lexical tones, whereas it precludes Dutch native speakers from reaching native level performance. Furthermore, the influence of acoustic variance was not uniform but asymmetric, dependent on the presentation order of the lexical tones to be discriminated. An exploratory analysis using an active adaptive oddball paradigm was used to quantify the extent of the perceptual asymmetry. We discuss two possible mechanisms underlying this asymmetry and propose possible paradigms to investigate these mechanisms
  • Holler, J. (2014). Experimental methods in co-speech gesture research. In C. Mueller, A. Cienki, D. McNeill, & E. Fricke (Eds.), Body -language – communication: An international handbook on multimodality in human interaction. Volume 1 (pp. 837-856). Berlin: De Gruyter.
  • Holler, J. (2010). Speakers’ use of interactive gestures to mark common ground. In S. Kopp, & I. Wachsmuth (Eds.), Gesture in embodied communication and human-computer interaction. 8th International Gesture Workshop, Bielefeld, Germany, 2009; Selected Revised Papers (pp. 11-22). Heidelberg: Springer Verlag.
  • Holler, J., & Beattie, G. (2004). The interaction of iconic gesture and speech. In A. Cammurri, & G. Volpe (Eds.), Lecture Notes in Computer Science, 5th International Gesture Workshop, Genova, Italy, 2003; Selected Revised Papers (pp. 63-69). Heidelberg: Springer Verlag.
  • De Hoop, H., & Narasimhan, B. (2005). Differential case-marking in Hindi. In M. Amberber, & H. de Hoop (Eds.), Competition and variation in natural languages: The case for case (pp. 321-345). Amsterdam: Elsevier.
  • Huettig, F. (2014). Role of prediction in language learning. In P. J. Brooks, & V. Kempe (Eds.), Encyclopedia of language development (pp. 479-481). London: Sage Publications.
  • Huettig, F., & Altmann, G. T. M. (2004). The online processing of ambiguous and unambiguous words in context: Evidence from head-mounted eye-tracking. In M. Carreiras, & C. Clifton (Eds.), The on-line study of sentence comprehension: Eyetracking, ERP and beyond (pp. 187-207). New York: Psychology Press.
  • Hulten, A. (2010). Sanan tuottaminen [Word production]. In Kieli ja aivot [Language and the Brain - Textbook series] (pp. 106-116).
  • Indefrey, P., & Cutler, A. (2004). Prelexical and lexical processing in listening. In M. Gazzaniga (Ed.), The cognitive neurosciences III. (pp. 759-774). Cambridge, MA: MIT Press.

    Abstract

    This paper presents a meta-analysis of hemodynamic studies on passive auditory language processing. We assess the overlap of hemodynamic activation areas and activation maxima reported in experiments involving the presentation of sentences, words, pseudowords, or sublexical or non-linguistic auditory stimuli. Areas that have been reliably replicated are identified. The results of the meta-analysis are compared to electrophysiological, magnetencephalic (MEG), and clinical findings. It is concluded that auditory language input is processed in a left posterior frontal and bilateral temporal cortical network. Within this network, no processing leve l is related to a single cortical area. The temporal lobes seem to differ with respect to their involvement in post-lexical processing, in that the left temporal lobe has greater involvement than the right, and also in the degree of anatomical specialization for phonological, lexical, and sentence -level processing, with greater overlap on the right contrasting with a higher degree of differentiation on the left.
  • Indefrey, P. (2004). Hirnaktivierungen bei syntaktischer Sprachverarbeitung: Eine Meta-Analyse. In H. Müller, & G. Rickheit (Eds.), Neurokognition der Sprache (pp. 31-50). Tübingen: Stauffenburg.
  • Indefrey, P., & Gullberg, M. (2010). The earliest stages of language learning: Introduction. In M. Gullberg, & P. Indefrey (Eds.), The earliest stages of language learning (pp. 1-4). Malden, MA: Wiley-Blackwell.
  • Janse, E. (2005). Lexical inhibition effects in time-compressed speech. In Proceedings of the 9th European Conference on Speech Communication and Technology [Interspeech 2005] (pp. 1757-1760).
  • Janse, E., & Quené, H. (1999). On the suitability of the cross-modal semantic priming task. In Proceedings of the XIVth International Congress of Phonetic Sciences (pp. 1937-1940).
  • Janzen, G. (2005). Wie das mensliche Gehirn Orientierung ermöglicht. In G. Plehn (Ed.), Jahrbuch der Max-Planck-Gesellschaft (pp. 599-601). Göttingen: Vandenhoeck & Ruprecht.
  • Janzen, G., & Weststeijn, C. (2004). Neural representation of object location and route direction: An fMRI study. NeuroImage, 22(Supplement 1), e634-e635.
  • Janzen, G., & Van Turennout, M. (2004). Neuronale Markierung navigationsrelevanter Objekte im räumlichen Gedächtnis: Ein fMRT Experiment. In D. Kerzel (Ed.), Beiträge zur 46. Tagung experimentell arbeitender Psychologen (pp. 125-125). Lengerich: Pabst Science Publishers.
  • Järvikivi, J., & Pyykkönen, P. (2010). Lauseiden ymmärtäminen [Engl. Sentence comprehension]. In P. Korpilahti, O. Aaltonen, & M. Laine (Eds.), Kieli ja aivot: Kommunikaation perusteet, häiriöt ja kuntoutus (pp. 117-125). Turku: Turku yliopisto.

    Abstract

    Kun kuuntelemme puhetta tai luemme tekstiä, alamme välittömästi rakentaa koherenttia tulkintaa. Toisin kuin lukemisessa, puheen havaitsemisessa kuulija voi harvoin kontrolloida nopeutta, jolla hänelle puhutaan. Huolimatta hyvin nopeasta syötteestä - noin 4-7 tavua sekunnissa - ihmiset kykenevät tulkitsemaan puhetta hyvin vaivattomasti. Lauseen ymmärtämisen tutkimuksessa selvitetäänkin, miten tällainen nopea ja useimmiten vaivaton tulkintaprosessi tapahtuu, mitkä kognitiiviset prosessit osallistuvat reaaliaikaiseen tulkintaan ja millaista informaatiota missäkin vaiheessa prosessointia ihminen käyttää hyväkseen johdonmukaisen tulkinnan muodostamiseksi. Tämä kappale on katsaus lauseen ymmärtämisen prosesseihin ja niiden tutkimukseen. Käsittelemme lyhyesti prosessointimalleja, aikuisten ja lasten kielen suhdetta, lauseen sisäisten ja välisten viittaussuhteiden tulkintaa ja sensorisen ympäristön sekä motorisen toiminnan roolia lauseiden tulkintaprosessissa.
  • Jasmin, K., & Casasanto, D. (2010). Stereotyping: How the QWERTY keyboard shapes the mental lexicon [Abstract]. In Proceedings of the 16th Annual Conference on Architectures and Mechanisms for Language Processing [AMLaP 2010] (pp. 159). York: University of York.
  • Jesse, A., Reinisch, E., & Nygaard, L. C. (2010). Learning of adjectival word meaning through tone of voice [Abstract]. Journal of the Acoustical Society of America, 128, 2475.

    Abstract

    Speakers express word meaning through systematic but non-canonical acoustic variation of tone of voice (ToV), i.e., variation of speaking rate, pitch, vocal effort, or loudness. Words are, for example, pronounced at a higher pitch when referring to small than to big referents. In the present study, we examined whether listeners can use ToV to learn the meaning of novel adjectives (e.g., “blicket”). During training, participants heard sentences such as “Can you find the blicket one?” spoken with ToV representing hot-cold, strong-weak, and big-small. Participants’ eye movements to two simultaneously shown objects with properties representing the relevant two endpoints (e.g., an elephant and an ant for big-small) were monitored. Assignment of novel adjectives to endpoints was counterbalanced across participants. During test, participants heard the sentences spoken with a neutral ToV, while seeing old or novel picture pairs varying along the same dimensions (e.g., a truck and a car for big-small). Participants had to click on the adjective’s referent. As evident from eye movements, participants did not infer the intended meaning during first exposure, but learned the meaning with the help of ToV during training. At test listeners applied this knowledge to old and novel items even in the absence of informative ToV.
  • Jesse, A., & Massaro, D. W. (2005). Towards a lexical fuzzy logical model of perception: The time-course of audiovisual speech processing in word identification. In E. Vatikiotis-Bateson, D. Burnham, & S. Fels (Eds.), Proceedings of the Auditory-Visual Speech Processing International Conference 2005 (pp. 35-36). Adelaide, Australia: Causal Productions.

    Abstract

    This study investigates the time-course of information processing in both visual as well as in the auditory speech as used for word identification in face-to-face communication. It extends the limited previous research on this topic and provides a valuable database for future research in audiovisual speech perception. An evaluation of models of speech perception by ear and eye in their ability to account for the audiovisual gating data shows a superior role of the fuzzy logical model of perception (FLMP) [1] over additive models of perception. A new dynamic version of the FLMP seems to be a promising model to account for the complex interplay of perceptual and cognitive information in audiovisual spoken word recognition.
  • Johns, T. G., Vitali, A. A., Perera, R. M., Vernes, S. C., & Scott, A. M. (2005). Ligand-independent activation of the EGFRvIII: A naturally occurring mutation of the EGFR commonly expressed in glioma [Abstract]. Neuro-Oncology, 7, 299.

    Abstract

    Mutations of the epidermal growth factor receptor (EGFR) gene are found at a relatively high frequency in glioma, with the most common being the de2-7 EGFR (or EGFRvIII). This mutation arises from an in-frame deletion of exons 2–7, which removes 267 amino acids from the extracellular domain of the receptor. Despite being unable to bind ligand, the de2-7 EGFR is constitutively active at a low level. Transfection of human glioma cells with the de2-7 EGFR has little effect in vitro, but when grown as tumor xenografts this mutated receptor imparts a dramatic growth advantage. We have now mapped the phosphorylation pattern of de2-7 EGFR, both in vivo and in vitro, using a panel of antibodies unique to the different phosphorylated tyrosine residues. Phosphorylation of de2-7 EGFR was detected constitutively at all tyrosine sites surveyed both in vitro and in vivo, including tyrosine 845, a known target in the wild-type EGFR for src kinase. There was a substantial upregulation of phosphorylation at every tyrosine residue of the de2-7 EGFR when cells were grown in vivo compared to the receptor isolated from cells cultured in vitro. Upregulation of phosphorylation could be mimicked in vitro by the addition of specifi c components of the ECM such as collagen via an integrin-dependent mechanism. Since this increase in in vivo phosphorylation enhances de2-7 EGFR signaling, this observation explains why the growth enhancement mediated by de2-7 EGFR is largely restricted to the in vivo environment. In a second set of experiments we analyzed the interaction between EGFRvIII and ErbB2. Co-expression of these proteins in NR6 cells, a mouse fi broblast line devoid of ErbB family members, dramatically enhanced in vivo tumorigenicity of these cells compared to cells expressing either protein alone. Detailed analysis of these xenografts demonstrated that EGFRvIII could heterodimerize and transphosphorylate the ErbB2. Since both EGFRvIII and ErbB2 are commonly expressed at gliomas, this data suggests that the co-expression of these two proteins may enhance glioma tumorigenicity.
  • Johns, T. G., Perera, R. M., Vitali, A. A., Vernes, S. C., & Scott, A. (2004). Phosphorylation of a glioma-specific mutation of the EGFR [Abstract]. Neuro-Oncology, 6, 317.

    Abstract

    Mutations of the epidermal growth factor receptor (EGFR) gene are found at a relatively high frequency in glioma, with the most common being the de2-7 EGFR (or EGFRvIII). This mutation arises from an in-frame deletion of exons 2-7, which removes 267 amino acids from the extracellular domain of the receptor. Despite being unable to bind ligand, the de2-7 EGFR is constitutively active at a low level. Transfection of human glioma cells with the de2-7 EGFR has little effect in vitro, but when grown as tumor xenografts this mutated receptor imparts a dramatic growth advantage. We mapped the phosphorylation pattern of de2-7 EGFR, both in vivo and in vitro, using a panel of antibodies specific for different phosphorylated tyrosine residues. Phosphorylation of de2-7 EGFR was detected constitutively at all tyrosine sites surveyed in vitro and in vivo, including tyrosine 845, a known target in the wild-type EGFR for src kinase. There was a substantial upregulation of phosphorylation at every yrosine residue of the de2-7 EGFR when cells were grown in vivo compared to the receptor isolated from cells cultured in vitro. Upregulation of phosphorylation at tyrosine 845 could be stimulated in vitro by the addition of specific components of the ECM via an integrindependent mechanism. These observations may partially explain why the growth enhancement mediated by de2-7 EGFR is largely restricted to the in vivo environment
  • Johnson, E. K. (2005). Grammatical gender and early word recognition in Dutch. In A. Brugos, M. R. Clark-Cotton, & S. Ha (Eds.), Proceedings of the 29th Boston University Conference on Language Developement (pp. 320-330). Sommervile, MA: Cascadilla Press.
  • Johnson, E. K., Westrek, E., & Nazzi, T. (2005). Language familiarity affects voice discrimination by seven-month-olds. In Proceedings of the ISCA Workshop on Plasticity in Speech Perception (PSP2005) (pp. 227-230).
  • Johnsrude, I., Davis, M., & Hervais-Adelman, A. (2005). From sound to meaning: Hierarchical processing in speech comprehension. In D. Pressnitzer, S. McAdams, A. DeCheveigne, & L. Collet (Eds.), Auditory Signal Processing: Physiology, Psychoacoustics, and Models (pp. 299-306). New York: Springer.
  • Jongen-Janner, E., Pijls, F., & Kempen, G. (1990). Intelligente programma's voor grammatica- en spellingonderwijs. In Q. De Kort, & G. Leerdam (Eds.), Computertoepassingen in de Neerlandistiek. Almere: Landelijke Vereniging van Neerlandici.
  • Jordan, F., & Mace, R. (2005). The evolution of human sex-ratio at birth: A bio-cultural analysis. In R. Mace, C. J. Holden, & S. Shennan (Eds.), The evolution of cultural diversity: A phylogenetic approach (pp. 207-216). London: UCL Press.
  • Jordens, P. (2004). Morphology in Second Language Acquisition. In G. Booij (Ed.), Morphologie: Ein internationales Handbuch zur Flexion und Wortbildung (pp. 1806-1816). Berlin: Walter de Gruyter.
  • Jung, D., Klessa, K., Duray, Z., Oszkó, B., Sipos, M., Szeverényi, S., Várnai, Z., Trilsbeek, P., & Váradi, T. (2014). Languagesindanger.eu - Including multimedia language resources to disseminate knowledge and create educational material on less-resourced languages. In N. Calzolari, K. Choukri, T. Declerck, H. Loftsson, B. Maegaard, J. Mariani, A. Moreno, J. Odijk, & S. Piperidis (Eds.), Proceedings of LREC 2014: 9th International Conference on Language Resources and Evaluation (pp. 530-535).

    Abstract

    The present paper describes the development of the languagesindanger.eu interactive website as an example of including multimedia language resources to disseminate knowledge and create educational material on less-resourced languages. The website is a product of INNET (Innovative networking in infrastructure for endangered languages), European FP7 project. Its main functions can be summarized as related to the three following areas: (1) raising students' awareness of language endangerment and arouse their interest in linguistic diversity, language maintenance and language documentation; (2) informing both students and teachers about these topics and show ways how they can enlarge their knowledge further with a special emphasis on information about language archives; (3) helping teachers include these topics into their classes. The website has been localized into five language versions with the intention to be accessible to both scientific and non-scientific communities such as (primarily) secondary school teachers and students, beginning university students of linguistics, journalists, the interested public, and also members of speech communities who speak minority languages
  • Junge, C., Hagoort, P., Kooijman, V., & Cutler, A. (2010). Brain potentials for word segmentation at seven months predict later language development. In K. Franich, K. M. Iserman, & L. L. Keil (Eds.), Proceedings of the 34th Annual Boston University Conference on Language Development. Volume 1 (pp. 209-220). Somerville, MA: Cascadilla Press.
  • Junge, C., Cutler, A., & Hagoort, P. (2010). Ability to segment words from speech as a precursor of later language development: Insights from electrophysiological responses in the infant brain. In M. Burgess, J. Davey, C. Don, & T. McMinn (Eds.), Proceedings of 20th International Congress on Acoustics, ICA 2010. Incorporating Proceedings of the 2010 annual conference of the Australian Acoustical Society (pp. 3727-3732). Australian Acoustical Society, NSW Division.
  • Kashima, Y., Kashima, E. S., & Kidd, E. (2014). Language and culture. In T. M. Holtgraves (Ed.), The Oxford Handbook of Language and Social Psychology (pp. 46-61). Oxford: Oxford University Press.
  • Kempen, G. (2004). Terug naar Wundt: Pleidooi voor integraal onderzoek van taal, taalkennis en taalgedrag. In Koninklijke Nederlandse Akademie van Wetenschappen (Ed.), Gij letterdames en gij letterheren': Nieuwe mogelijkheden voor taalkundig en letterkundig onderzoek in Nederland. (pp. 174-188). Amsterdam: Koninklijke Nederlandse Akademie van Wetenschappen.
  • Kempen, G., & Harbusch, K. (2005). The relationship between grammaticality ratings and corpus frequencies: A case study into word order variability in the midfield of German clauses. In S. Kepser, & M. Reis (Eds.), Linguistic evidence - emperical, theoretical, and computational perspectives (pp. 329-349). Berlin: Mouton de Gruyter.
  • Kempen, G. (1986). Beyond word processing. In E. Cluff, & G. Bunting (Eds.), Information management yearbook 1986 (pp. 178-181). London: IDPM Publications.
  • Kempen, G. (1979). A study of syntactic bookkeeping during sentence production. In H. Ueckert, & D. Rhenius (Eds.), Komplexe menschliche Informationsverarbeitung (pp. 361-368). Bern: Hans Huber.

    Abstract

    It is an important feature of the human sentence production system that semantic and syntactic processes may overlap in time and do not proceed strictly serially. That is, the process of building the syntactic form of an utterance does not always wait until the complete semantic content for that utterance has been decided upon. On the contrary, speakers will often start pronouncing the first words of a sentence while still working on further details of its semantic content. An important advantage is memory economy. Semantic and syntactic fragments do not have to occupy working memory until complete semantic and syntactic structures for an utterance have been computed. Instead, each semantic and syntactic fragment is processed as soon as possible and is kept in working memory for a minimum period of time. This raises the question of how the sentence production system can maintain syntactic coherence across syntactic fragments. Presumably there are processes of "syntactic bookkeeping" which (1) store in working memory those syntactic properties of a fragmentary sentence which are needed to eliminate ungrammatical continuations, and (2) check whether a prospective continuation is indeed compatible with the sentence constructed so far. In reaction time experiments where subjects described, under time pressure, simple static pictures of an action performed by an actor, the second aspect of syntactic bookkeeping could be demonstrated. This evidence is used for modelling bookkeeping processes as part of a computational sentence generator which aims at simulating the syntactic operations people carry out during spontaneous speech.
  • Kempen, G., & Harbusch, K. (2004). A corpus study into word order variation in German subordinate clauses: Animacy affects linearization independently of grammatical function assignment. In T. Pechmann, & C. Habel (Eds.), Multidisciplinary approaches to language production (pp. 173-181). Berlin: Mouton de Gruyter.
  • Kempen, G., & Harbusch, K. (2004). Generating natural word orders in a semi-free word order language: Treebank-based linearization preferences for German. In A. Gelbukh (Ed.), Computational Linguistics and Intelligent Text Processing (pp. 350-354). Berlin: Springer.

    Abstract

    We outline an algorithm capable of generating varied but natural sounding sequences of argument NPs in subordinate clauses of German, a semi-free word order language. In order to attain the right level of output flexibility, the algorithm considers (1) the relevant lexical properties of the head verb (not only transitivity type but also reflexivity, thematic relations expressed by the NPs, etc.), and (2) the animacy and definiteness values of the arguments, and their length. The relevant statistical data were extracted from the NEGRA–II treebank and from hand-coded features for animacy and definiteness. The algorithm maps the relevant properties onto “primary” versus “secondary” placement options in the generator. The algorithm is restricted in that it does not take into account linear order determinants related to the sentence’s information structure and its discourse context (e.g. contrastiveness). These factors may modulate the above preferences or license “tertiary” linear orders beyond the primary and secondary options considered here.
  • Kempen, G., & Harbusch, K. (2004). How flexible is constituent order in the midfield of German subordinate clauses? A corpus study revealing unexpected rigidity. In S. Kepser, & M. Reis (Eds.), Pre-Proceedings of the International Conference on Linguistic Evidence (pp. 81-85). Tübingen: Niemeyer.
  • Kempen, G. (2004). Interactive visualization of syntactic structure assembly for grammar-intensive first- and second-language instruction. In R. Delmonte, P. Delcloque, & S. Tonelli (Eds.), Proceedings of InSTIL/ICALL2004 Symposium on NLP and speech technologies in advanced language learning systems (pp. 183-186). Venice: University of Venice.
  • Kempen, G., & Harbusch, K. (2004). How flexible is constituent order in the midfield of German subordinate clauses?: A corpus study revealing unexpected rigidity. In Proceedings of the International Conference on Linguistic Evidence (pp. 81-85). Tübingen: University of Tübingen.
  • Kempen, G. (2004). Human grammatical coding: Shared structure formation resources for grammatical encoding and decoding. In Cuny 2004 - The 17th Annual CUNY Conference on Human Sentence Processing. March 25-27, 2004. University of Maryland (pp. 66).
  • Kempen, G., & Hoenkamp, E. (1982). Incremental sentence generation: Implications for the structure of a syntactic processor. In J. Horecký (Ed.), COLING 82. Proceedings of the Ninth International Conference on Computational Linguistics, Prague, July 5-10, 1982 (pp. 151-156). Amsterdam: North-Holland.

    Abstract

    Human speakers often produce sentences incrementally. They can start speaking having in mind only a fragmentary idea of what they want to say, and while saying this they refine the contents underlying subsequent parts of the utterance. This capability imposes a number of constraints on the design of a syntactic processor. This paper explores these constraints and evaluates some recent computational sentence generators from the perspective of incremental production.
  • Kempen, G. (1986). Kunstmatige intelligentie en gezond verstand. In P. Hagoort, & R. Maessen (Eds.), Geest, computer, kunst (pp. 118-123). Utrecht: Stichting Grafiet.
  • Kempen, G., & Olsthoorn, N. (2005). Non-parallelism of grammatical encoding and decoding due to shared working memory [Abstract]. In AMLaP-2005 11th Annual Conference on Architectures and Mechanisms for Language Processing September 5-7, 2005 Ghent, Belgium (pp. 24).
  • Kempen, G. (1999). Visual Grammar: Multimedia for grammar and spelling instruction in primary education. In K. Cameron (Ed.), CALL: Media, design, and applications (pp. 223-238). Lisse: Swets & Zeitlinger.
  • Kemps-Snijders, M., Koller, T., Sloetjes, H., & Verweij, H. (2010). LAT bridge: Bridging tools for annotation and exploration of rich linguistic data. In N. Calzolari, B. Maegaard, J. Mariani, J. Odjik, K. Choukri, S. Piperidis, M. Rosner, & D. Tapias (Eds.), Proceedings of the Seventh conference on International Language Resources and Evaluation (LREC'10) (pp. 2648-2651). European Language Resources Association (ELRA).

    Abstract

    We present a software module, the LAT Bridge, which enables bidirectionalcommunication between the annotation and exploration tools developed at the MaxPlanck Institute for Psycholinguistics as part of our Language ArchivingTechnology (LAT) tool suite. These existing annotation and exploration toolsenable the annotation, enrichment, exploration and archive management oflinguistic resources. The user community has expressed the desire to usedifferent combinations of LAT tools in conjunction with each other. The LATBridge is designed to cater for a number of basic data interaction scenariosbetween the LAT annotation and exploration tools. These interaction scenarios(e.g. bootstrapping a wordlist, searching for annotation examples or lexicalentries) have been identified in collaboration with researchers at ourinstitute.We had to take into account that the LAT tools for annotation and explorationrepresent a heterogeneous application scenario with desktop-installed andweb-based tools. Additionally, the LAT Bridge has to work in situations wherethe Internet is not available or only in an unreliable manner (i.e. with a slowconnection or with frequent interruptions). As a result, the LAT Bridge’sarchitecture supports both online and offline communication between the LATannotation and exploration tools.
  • Kendrick, K. H., & Drew, P. (2014). The putative preference for offers over requests. In P. Drew, & E. Couper-Kuhlen (Eds.), Requesting in Social Interaction (pp. 87-113). Amsterdam: John Benjamins Publishing Company.

    Abstract

    Requesting and offering are closely related, insofar as they are activities associated with someone’s need for assistance. It has been supposed (e.g., Schegloff 2007) that requests and offers are not equivalent actions – specifically that offers are preferred actions and requests are dispreferred. We review the evidence for this claim across a corpus of requests and offers and demonstrate that the empirical evidence does not support the claim for a putative preference for offers over requests. Further consideration of the often symbiotic relationships between requesting and offering, particularly in face-to-face interactions, reveals a more complex picture of the ways in which people recruit others to help, or in which others are mobilized to help.
  • Khetarpal, N., Majid, A., Malt, B. C., Sloman, S., & Regier, T. (2010). Similarity judgments reflect both language and cross-language tendencies: Evidence from two semantic domains. In S. Ohlsson, & R. Catrambone (Eds.), Proceedings of the 32nd Annual Conference of the Cognitive Science Society (pp. 358-363). Austin, TX: Cognitive Science Society.

    Abstract

    Many theories hold that semantic variation in the world’s languages can be explained in terms of a universal conceptual space that is partitioned differently by different languages. Recent work has supported this view in the semantic domain of containers (Malt et al., 1999), and assumed it in the domain of spatial relations (Khetarpal et al., 2009), based in both cases on similarity judgments derived from pile-sorting of stimuli. Here, we reanalyze data from these two studies and find a more complex picture than these earlier studies suggested. In both cases we find that sorting is similar across speakers of different languages (in line with the earlier studies), but nonetheless reflects the sorter’s native language (in contrast with the earlier studies). We conclude that there are cross-culturally shared conceptual tendencies that can be revealed by pile-sorting, but that these tendencies may be modulated to some extent by language. We discuss the implications of these findings for accounts of semantic variation.
  • Kita, S., Ozyurek, A., Allen, S., & Ishizuka, T. (2010). Early links between iconic gestures and sound symbolic words: Evidence for multimodal protolanguage. In A. D. Smith, M. Schouwstra, B. de Boer, & K. Smith (Eds.), Proceedings of the 8th International conference on the Evolution of Language (EVOLANG 8) (pp. 429-430). Singapore: World Scientific.
  • Kita, S., & Ozyurek, A. (1999). Semantische Koordination zwischen Sprache und spontanen ikonischen Gesten: Eine sprachvergleichende Untersuchung. In Max-Planck-Gesellschaft (Ed.), Jahrbuch 1998 (pp. 388-391). Göttingen: Vandenhoeck & Ruprecht.
  • Klatter-Folmer, J., Van Hout, R., Van den Heuvel, H., Fikkert, P., Baker, A., De Jong, J., Wijnen, F., Sanders, E., & Trilsbeek, P. (2014). Vulnerability in acquisition, language impairments in Dutch: Creating a VALID data archive. In N. Calzolari, K. Choukri, T. Declerck, H. Loftsson, B. Maegaard, J. Mariani, A. Moreno, J. Odijk, & S. Piperidis (Eds.), Proceedings of LREC 2014: 9th International Conference on Language Resources and Evaluation (pp. 357-364).

    Abstract

    The VALID Data Archive is an open multimedia data archive (under construction) with data from speakers suffering from language impairments. We report on a pilot project in the CLARIN-NL framework in which five data resources were curated. For all data sets concerned, written informed consent from the participants or their caretakers has been obtained. All materials were anonymized. The audio files were converted into wav (linear PCM) files and the transcriptions into CHAT or ELAN format. Research data that consisted of test, SPSS and Excel files were documented and converted into CSV files. All data sets obtained appropriate CMDI metadata files. A new CMDI metadata profile for this type of data resources was established and care was taken that ISOcat metadata categories were used to optimize interoperability. After curation all data are deposited at the Max Planck Institute for Psycholinguistics Nijmegen where persistent identifiers are linked to all resources. The content of the transcriptions in CHAT and plain text format can be searched with the TROVA search engine
  • Klein, W. (2005). Söldner des Wissens. In R. Kiesow, R. Ogorek, & S. Simitis (Eds.), Summa: Dieter Simon zum 70. Geburtstag (pp. 319-332). Frankfurt am Main: Klostermann.
  • Klein, W. (Ed.). (2004). Philologie auf neuen Wegen [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, 136.
  • Klein, W., & Dimroth, C. (Eds.). (2005). Spracherwerb [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, 140.
  • Klein, W. (2005). The grammar of varieties. In U. Ammon, N. Dittmar, K. J. Mattheier, & P. Trudgill (Eds.), Sociolinguistics: An international handbook of the Science of Language and Society (pp. 1163-1171). Berlin: Walter de Gruyter.
  • Klein, W. (Ed.). (2004). Universitas [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik (LiLi), 134.
  • Klein, W., & Musan, R. (Eds.). (1999). Das deutsche Perfekt [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (113).
  • Klein, W., & Geyken, A. (2010). Das Digitale Wörterbuch der Deutschen Sprache (DWDS). In U. Heid, S. Schierholz, W. Schweickard, H. E. Wiegand, R. H. Gouws, & W. Wolski (Eds.), Lexicographica: International annual for lexicography (pp. 79-96). Berlin, New York: De Gruyter.

    Abstract

    No area in the study of human languages has a longer history and a higher practical signifi cance than lexicography. The advent of the computer has dramaticually changed this discipline in ways which go far beyond the digitisation of materials in combination with effi cient search tools, or the transfer of an existing dictionary onto the computer. They allow the stepwise elaboration of what is called here Digital Lexical Systems, i.e., computerized systems in which the underlying data - in form of an extendable corpus - and description of lexical properties on various levels can be effi ciently combined. This paper discusses the range of these possibilities and describes the present form of the German „Digital Lexical System of the Academy“, a project of the Berlin-Brandenburg Academy of Sciences (www.dwds.de).
  • Klein, W. (2010). Der mühselige Weg zur Erforschung des Schönen. In S. Walther, G. Staupe, & T. Macho (Eds.), Was ist schön? Begleitbuch zur Ausstellung (pp. 124-131). Göttingen: Wallstein.
  • Klein, W. (1976). Der Prozeß des Zweitspracherwerbs und seine Beschreibung. In R. Dietrich (Ed.), Aspekte des Fremdsprachenerwerbs (pp. 100-118). Kronberg/Ts.: Athenäum.
  • Klein, W. (1999). Die Lehren des Zweitspracherwerbs. In N. Dittmar, & A. Ramat (Eds.), Grammatik und Diskurs: Studien zum Erwerb des Deutschen und des Italienischen (pp. 279-290). Tübingen: Stauffenberg.
  • Klein, W., & Perdue, C. (1986). Comment résourdre une tache verbale complexe avec peu de moyens linguistiques? In A. Giacomi, & D. Véronique (Eds.), Acquisition d'une langue étrangère (pp. 306-330). Aix-en-Provence: Service des Publications de l'Universite de Provence.
  • Klein, W., & Winkler, S. (Eds.). (2010). Ambiguität [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, 40(158).
  • Klein, W. (2004). Das Digitale Wörterbuch der deutschen Sprache des 20. Jahrhunderts (DWDS). In J. Scharnhorst (Ed.), Sprachkultur und Lexikographie (pp. 281-311). Berlin: Peter Lang.
  • Klein, W. (1979). Die Geschichte eines Tores. In R. Baum, F. J. Hausmann, & I. Monreal-Wickert (Eds.), Sprache in Unterricht und Forschung: Schwerpunkt Romanistik (pp. 175-194). Tübingen: Narr.
  • Klein, W. (2005). Der alte und der neue Grimm. In Grimm-Sozietät (Ed.), Die Brüder Grimm in Berlin (pp. 167-176). Stuttgart: Hirzel.
  • Klein, W. (Ed.). (2005). Nicht nur Literatur [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, 137.
  • Klein, W. (1976). Maschinelle Analyse des Sprachwandels. In P. Eisenberg (Ed.), Maschinelle Sprachanalyse (pp. 137-166). Berlin: de Gruyter.
  • Klein, W. (1990). Language acquisition. In M. Piattelli Palmarini (Ed.), Cognitive science in Europe: Issues and trends: Golem monograph series, 1 (pp. 65-77). Ivrea: Golem.
  • Klein, W. (1982). Local deixis in route directions. In R. Jarvella, & W. Klein (Eds.), Speech, place, and action: Studies in deixis and related topics (pp. 161-182). New York: Wiley.

Share this page