Publications

Abstract

Mutations of the epidermal growth factor receptor (EGFR) gene are found at a relatively high frequency in glioma, with the most common being the de2-7 EGFR (or EGFRvIII). This mutation arises from an in-frame deletion of exons 2-7, which removes 267 amino acids from the extracellular domain of the receptor. Despite being unable to bind ligand, the de2-7 EGFR is constitutively active at a low level. Transfection of human glioma cells with the de2-7 EGFR has little effect in vitro, but when grown as tumor xenografts this mutated receptor imparts a dramatic growth advantage. We mapped the phosphorylation pattern of de2-7 EGFR, both in vivo and in vitro, using a panel of antibodies specific for different phosphorylated tyrosine residues. Phosphorylation of de2-7 EGFR was detected constitutively at all tyrosine sites surveyed in vitro and in vivo, including tyrosine 845, a known target in the wild-type EGFR for src kinase. There was a substantial upregulation of phosphorylation at every yrosine residue of the de2-7 EGFR when cells were grown in vivo compared to the receptor isolated from cells cultured in vitro. Upregulation of phosphorylation at tyrosine 845 could be stimulated in vitro by the addition of specific components of the ECM via an integrindependent mechanism. These observations may partially explain why the growth enhancement mediated by de2-7 EGFR is largely restricted to the in vivo environment

Abstract

A wealth of studies has shown that more proficient monolingual speakers are better at predicting upcoming information during language comprehension. Similarly, prediction skills of adult second language (L2) speakers in their L2 have also been argued to be modulated by their L2 proficiency. How exactly language proficiency and prediction are linked, however, is yet to be systematically investigated. One group of language users which has the potential to provide invaluable insights into this link is bilingual children. In this paper, we compare bilingual children’s prediction skills with those of monolingual children and adult L2 speakers, and show how investigating bilingual children’s prediction skills may contribute to our understanding of how predictive processing works.

Abstract

There is a strong relation between children’s exposure to
spatial terms and their later memory accuracy. In the current
study, we tested whether the production of spatial terms by
children themselves predicts memory accuracy and whether
and how language modality of these encodings modulates
memory accuracy differently. Hearing child speakers of
Turkish and deaf child signers of Turkish Sign Language
described pictures of objects in various spatial relations to each
other and later tested for their memory accuracy of these
pictures in a surprise memory task. We found that having
described the spatial relation between the objects predicted
better memory accuracy. However, the modality of these
descriptions in sign, speech, or speech-plus-gesture did not
reveal differences in memory accuracy. We discuss the
implications of these findings for the relation between spatial
language, memory, and the modality of encoding.

Abstract

This paper is an abridged version (in Dutch) of an in-press article by the same author (Kempen, G. (2008/9). Clausal coordination and coordinate ellipsis in a model of the speaker. To be published in: Linguistics). The two papers present a psycholinguistically inspired approach to the syntax of clause-level coordination and coordinate ellipsis. It departs from the assumption that coordinations are structurally similar to so-called appropriateness repairs Ñ an important type of self-repairs in spontaneous speech. Coordinate structures and appropriateness repairs can both be viewed as ÒupdateÓ con-structions. Updating is defined as a special sentence production mode that efficiently revises or augments existing sentential structure in response to modifications in the speakerÕs communicative intention. This perspective is shown to offer an empirically satisfactory and theoretically parsimonious account of two prominent types of coordinate ellipsis, in particular Forward Conjunction Reduction (FCR) and Gapping (including Long-Distance Gapping and Subgapping). They are analyzed as different manifestations of Òincremental updatingÓ Ñ efficient updating of only part of the existing sentential structure. Based on empirical data from Dutch and German, novel treatments are proposed for both types of clausal coordinate ellipsis. Two other forms of coordinate ellipsis Ñ SGF (ÒSubject Gap in Finite clauses with fronted verbÓ), and Backward Conjunction Reduction (BCR; also known as Right Node Raising or RNR) Ñ are shown to be incompatible with the notion of incremental updating. Alternative theoretical interpretations of these phenomena are proposed. The four types of clausal coordinate ellipsis Ñ SGF, Gapping, FCR and BCR Ñ are argued to originate in four different stages of sentence production: Intending (i.e. preparing the communicative intention), Conceptualization, Grammatical Encoding, and Phonological Encoding, respectively.

Abstract

We outline an algorithm capable of generating varied but natural sounding sequences of argument NPs in subordinate clauses of German, a semi-free word order language. In order to attain the right level of output flexibility, the algorithm considers (1) the relevant lexical properties of the head verb (not only transitivity type but also reflexivity, thematic relations expressed by the NPs, etc.), and (2) the animacy and definiteness values of the arguments, and their length. The relevant statistical data were extracted from the NEGRA–II treebank and from hand-coded features for animacy and definiteness. The algorithm maps the relevant properties onto “primary” versus “secondary” placement options in the generator. The algorithm is restricted in that it does not take into account linear order determinants related to the sentence’s information structure and its discourse context (e.g. contrastiveness). These factors may modulate the above preferences or license “tertiary” linear orders beyond the primary and secondary options considered here.

Abstract

Language documentation involves linguistic analysis of the collected material, which is typically done manually. Automatic methods for language processing usually require large corpora. The method presented in this paper uses techniques from bioinformatics and contextual information to morphologically analyze raw text corpora. This paper presents initial results of the method when applied on a small Kilivila corpus.

Abstract

The previous literature has suggested that the hand movement in co-speech gestures and signs consists of a series of phases with qualitatively different dynamic characteristics. In this paper, we propose a syntagmatic rule system for movement phases that applies to both co-speech gestures and signs. Descriptive criteria for the rule system were developed for the analysis video-recorded continuous production of signs and gesture. It involves segmenting a stream of body movement into phases and identifying different phase types. Two human coders used the criteria to analyze signs and cospeech gestures that are produced in natural discourse. It was found that the criteria yielded good inter-coder reliability. These criteria can be used for the technology of automatic recognition of signs and co-speech gestures in order to segment continuous production and identify the potentially meaningbearing phase.

Abstract

This chapter explores the expression of placement (or Goal-oriented) and removal (or Source-oriented) events by speakers of Polish (a West Slavic language). Its aim is to investigate the hypothesis known as ‘Source/Goal asymmetry’ according to which languages tend to favor the expression of Goals (e.g., into, onto) and to encode them more systematically and in a more fine-grained way than Sources (e.g., from, out of). The study provides both evidence and counter-evidence for Source/Goal asymmetry. On the one hand, it shows that Polish speakers use a greater variety of verbs to convey Manner and/or mode of manipulation in the expression of placement, encoding such events in a more fine-grained manner than removal events. The expression of placement is also characterized by a greater variety of verb prefixes conveying Path and prepositional phrases (including prepositions and case markers) conveying Ground. On the other hand, the study reveals that Polish speakers attend to Sources as often as to Goals, revealing no evidence for an attentional bias toward the endpoints of events.

Abstract

Like Einstein's general theory of relativity is concerned with explaining the basics of an observable experience – i.e., gravity – most people take for granted that Chomsky's theory of generative grammar (GG) is concerned with the basic nature of language. This chapter highlights a mere subset of central constructs in GG, showing how they have featured prominently and thus shaped formal linguistic studies in multilingualism. Because multilingualism includes a wide range of nonmonolingual populations, the constructs are divided across child bilingualism and adult third language for greater coverage. In the case of the former, the chapter examines how poverty of the stimulus has been investigated. Using the nascent field of L3/Ln acquisition as the backdrop, it discusses how the GG constructs of I-language versus E-language sit at the core of debates regarding the very notion of what linguistic transfer and mental representations should be taken to be.

Abstract

The present study investigates the influence of prosodic structure on the fine-grained phonetic details of German plosives which also cue the phonological fortis-lenis contrast. Closure durations were found to be longer at higher prosodic boundaries. There was also less glottal vibration in lenis plosives at higher prosodic boundaries. Voice onset time in lenis plosives was not affected by prosody. In contrast, for the fortis plosives VOT decreased at higher boundaries, as did the maximal intensity of the release. These results demonstrate that the effects of prosody on different phonetic cues can go into opposite directions, but are overall constrained by the need to maintain phonological contrasts. While prosodic effects on some cues are compatible with a ‘fortition’ account of prosodic strengthening or with a general feature enhancement explanation, the effects on others enhance paradigmatic contrasts only within a given prosodic position.

Abstract

In this study, we explored methods for linking Chinese and English sense inventories using two opposing approaches: creating links (1) bottom-up: by starting at the finer-grained sense level then proceeding to the verb subcategorization frames and (2) top-down: by starting directly with the more coarse-grained frame levels. The sense inventories for linking include pre-existing corpora, such as English Propbank (Palmer, Gildea, and Kingsbury, 2005), Chinese Propbank (Xue and Palmer, 2004) and English WordNet (Fellbaum, 1998) and newly created corpora, the English and Chinese Sense Inventories from DARPA-GALE OntoNotes. In the linking task, we selected a group of highly frequent and polysemous communication verbs, including say, ask, talk, and speak in English, and shuo, biao-shi, jiang, and wen in Chinese. We found that with the bottom-up method, although speakers of both languages agreed on the links between senses, the subcategorization frames of the corresponding senses did not match consistently. With the top-down method, if the verb frames match in both languages, their senses line up more quickly to each other. The results indicate that the top-down method is more promising in linking English and Chinese sense inventories.

Abstract

In different fields of the humanities annotations of multimodal resources are a necessary component of the research workflow. Examples include linguistics, psychology, anthropology, etc. However, creation of those annotations is a very laborious task, which can take 50 to 100 times the length of the annotated media, or more. This can be significantly improved by applying innovative audio and video processing algorithms, which analyze the recordings and provide automated annotations. This is the aim of the AVATecH project, which is a collaboration of the Max Planck Institute for Psycholinguistics (MPI) and the Fraunhofer institutes HHI and IAIS. In this paper we present a set of results of automated annotation together with an evaluation of their quality.

Abstract

Introduction Human spoken communication is multimodal, i.e. it encompasses both speech and gesture. Acoustic properties of voice, body movements, facial expression, etc. are an inherent and meaningful part of spoken interaction; they can provide attitudinal, grammatical and semantic information. In the recent years interest in audio-visual corpora has been rising rapidly as they enable investigation of different communicative modalities and provide more holistic view on communication (Kipp et al. 2009). Moreover, for some languages such corpora are the only available resource, as is the case for endangered languages for which no written resources exist.

Abstract

In this paper we describe audio and video processing algorithms that are developed in the scope of AVATecH project. The purpose of these algorithms is to shorten the time taken by manual annotation of audio and video recordings by extracting features from media files and creating semi-automated annotations. We show that the use of such supporting algorithms can shorten the annotation time to 30-50% of the time necessary to perform a fully manual annotation of the same kind.

Abstract

This chapter explicates the requirement in person–reference for balancing demands for recognition, minimalization, explicitness and indirection. This is illustrated with reference to data from repair of failures of person–reference within a particular linguistic/cultural context, namely casual interaction among Rossel Islanders. Rossel Island (PNG) offers a ‘natural experiment’ for studying aspects of person reference, because of a number of special properties: 1. It is a closed universe of 4000 souls, sharing one kinship network, so in principle anyone could be recognizable from a reference. As a result no (complex) descriptions (cf. ‘ the author of Waverly’) are employed. 2. Names, however, are never uniquely referring, since they are drawn from a fixed pool. They are only used for about 25% of initial references, another 25% of initial references being done by kinship triangulation (‘that man’s father–in–law’). Nearly 50% of initial references are semantically underspecified or vague (e.g. ‘that girl’). 3. There are systematic motivations for oblique reference, e.g. kinship–based taboos and other constraints, which partly account for the underspecified references. The ‘natural experiment’ thus reveals some gneral lessons about how person–reference requires optimizing multiple conflicting constraints. Comparison with Sacks and Schegloff’s (1979) treatment of English person reference suggests a way to tease apart the universal and the culturally–particular.

Abstract

This paper describes the linguistic treatment of placement events in the Rossel Island (Papua New Guinea) language Yélî Dnye. Yélî Dnye is unusual in treating PUT and TAKE events symmetrically with a remarkable consistency. In what follows, we first provide a brief background for the language, then describe the six core PUT/TAKE verbs that were drawn upon by Yélî Dnye speakers to describe the great majority of the PUT/TAKE stimuli clips, along with some of their grammatical properties. In Section 5 we describe alternative verbs usable in particular circumstances and give an indication of the basis for variability in responses across speakers. Section 6 presents some reasons why the Yélî verb pattern for expressing PUT and TAKE events is of broad interest.

Abstract

This chapter provides an overview of the Papuan and the Oceanic languages (a branch of Austronesian) in Northern Island Melanesia, as well as phenomena arising through contact between these groups. It shows how linguistics can contribute to the understanding of the history of languages and speakers, and what the findings of those methods have been. The location of the homeland of speakers of Proto-Oceanic is indicated (in northeast New Britain); many facets of the lives of those speakers are shown; and the patterns of their subsequent spread across Island Melanesia and beyond into Remote Oceania are indicated, followed by a second wave overlaying the first into New Guinea and as far as halfway through the Solomon Islands. Regarding the Papuan languages of this region, at least some are older than the 6,000-10,000 ceiling of the Comparative Method, and their relations are explored with the aid of a database of 125 non-lexical structural features. The results reflect archipelago-based clustering with the Central Solomons Papuan languages forming a clade either with the Bismarcks or with Bougainville languages. Papuan languages in Bougainville are less influenced by Oceanic languages than those in the Bismarcks and the Solomons. The chapter considers a variety of scenarios to account for their findings, concluding that the results are compatible with multiple pre-Oceanic waves of arrivals into the area after initial settlement.

Abstract

This paper investigates infant pointing at 12 months. Three recent experimental studies from our lab are reported and contrasted with existing accounts on infant communicative and social-cognitive abilities. The new results show that infant pointing at 12 months already is a communicative act which involves the intentional transmission of information to share interest with, or provide information for other persons. It is argued that infant pointing is an inherently social and cooperative act which is used to share psychological relations between interlocutors and environment, repairs misunderstandings in proto-conversational turn-taking, and helps others by providing information. Infant pointing builds on an understanding of others as persons with attentional states and attitudes. Findings do not support lean accounts on early infant pointing which posit that it is initially non-communicative, does not serve the function of indicating, or is purely self-centered. It is suggested to investigate the emergence of reference and the motivation to jointly engage with others also before pointing has emerged.

Abstract

There are two tasks for conducting systematic observation of child-caregiver joint attention interactions. Task 1 – a “decorated room” designed to elicit infant and caregiver pointing. Task 2 – videotaped interviews about infant pointing behaviour. The goal of this task is to document the ontogenetic emergence of referential communication in caregiver infant interaction in different cultures, during the critical age of 8-15 months when children come to understand and share others’ intentions. This is of interest to all students of interaction and human communication; it does not require specialist knowledge of children.

Abstract

The human body is unique: it is both an object of perception and the source of human experience. Its universality makes it a perfect resource for asking questions about how cognition, brain and typology relate to one another. For example, we can ask how speakers of different languages segment and categorize the human body. A dominant view is that body parts are “given” by visual perceptual discontinuities, and that words are merely labels for these visually determined parts (e.g., Andersen, 1978; Brown, 1976; Lakoff, 1987). However, there are problems with this view. First it ignores other perceptual information, such as somatosensory and motoric representations. By looking at the neural representations of sesnsory representations, we can test how much of the categorization of the human body can be done through perception alone. Second, we can look at language typology to see how much universality and variation there is in body-part categories. A comparison of a range of typologically, genetically and areally diverse languages shows that the perceptual view has only limited applicability (Majid, Enfield & van Staden, in press). For example, using a “coloring-in” task, where speakers of seven different languages were given a line drawing of a human body and asked to color in various body parts, Majid & van Staden (in prep) show that languages vary substantially in body part segmentation. For example, Jahai (Mon-Khmer) makes a lexical distinction between upper arm, lower arm, and hand, but Lavukaleve (Papuan Isolate) has just one word to refer to arm, hand, and leg. This shows that body part categorization is not a straightforward mapping of words to visually determined perceptual parts.

Abstract

Many studies in cognitive science address how people categorize objects, but there has been comparatively little research on event categorization. This study investigated the categorization of events involving material destruction, such as “cutting” and “breaking”. Speakers of 28 typologically, genetically, and areally diverse languages described events shown in a set of video-clips. There was considerable cross-linguistic agreement in the dimensions along which the events were distinguished, but there was variation in the number of categories and the placement of their boundaries.

Abstract

Scholars disagree about the extent to which language can tell us
about conceptualisation of the world. Some believe that language
is a direct window onto concepts: Having a word ‘‘bird’’, ‘‘table’’ or
‘‘sour’’ presupposes the corresponding underlying concept, BIRD,
TABLE, SOUR. Others disagree. Words are thought to be uninformative,
or worse, misleading about our underlying conceptual representations;
after all, our mental worlds are full of ideas that we
struggle to express in language. How could this be so, argue sceptics,
if language were a direct window on our inner life? In this presentation,
I consider what language can tell us about the
conceptualisation of taste. By considering linguistic data from
twenty unrelated cultures – varying in subsistence mode (huntergatherer
to industrial), ecological zone (rainforest jungle to desert),
dwelling type (rural and urban), and so forth – I argue any single language is, indeed, impoverished about what it can reveal about
taste. But recurrent lexicalisation patterns across languages can
provide valuable insights about human taste experience. Moreover,
language patterning is part of the data that a good theory of taste
perception has to be answerable for. Taste researchers, therefore,
cannot ignore the crosslinguistic facts.

Abstract

Readers experience a number of sensations during reading. They do
not – or do not only – process words and sentences in a detached, abstract
manner. Instead they “perceive” what they read about. They see descriptions of
scenery, feel what characters feel, and hear the sounds in a story. These sensa-
tions tend to be grouped under the umbrella terms “mental simulation” and
“mental imagery.” This chapter provides an overview of empirical research on
the role of mental simulation during literary reading. Our chapter also discusses
what mental simulation is and how it relates to mental imagery. Moreover, it
explores how mental simulation plays a role in leading models of literary read-
ing and investigates under what circumstances mental simulation occurs dur-
ing literature reading. Finally, the effect of mental simulation on the literary
reader’s experience is discussed, and suggestions and unresolved issues in this
field are formulated.

Abstract

Visual and auditory channels have different affordances and
this is mirrored in what information is available for linguistic
encoding. The visual channel has high spatial acuity, whereas
the auditory channel has better temporal acuity. These
differences may lead to different conceptualizations of events
and affect multimodal language production. Previous studies of
motion events typically present visual input to elicit speech and
gesture. The present study compared events presented as audio-
only, visual-only, or multimodal (visual+audio) input and
assessed speech and co-speech gesture for path and manner of
motion in Turkish. Speakers with audio-only input mentioned
path more and manner less in verbal descriptions, compared to
speakers who had visual input. There was no difference in the
type or frequency of gestures across conditions, and gestures
were dominated by path-only gestures. This suggests that input
modality influences speakers’ encoding of path and manner of
motion events in speech, but not in co-speech gestures.

Abstract

La ciencia moderna nace de la conjunción entre postulados teóricos y el desarrollo de una infraestructura tecnológica que permite observar los hechos de manera adecuada, realizar experimentos y verificar las hipótesis. Desde Galileo, ciencia y tecnología han avanzado conjuntamente. En el mundo occidental, la ciencia ha evolucionado desde pro-puestas puramente especulativas (basadas en postulados apriorísticos) hasta el uso de métodos experimentales y estadísticos para explicar mejor nuestras observaciones. La tecnología se hermana con la ciencia facilitando al investigador una aproximación adecuada a los hechos que pretende explicar. Así, Galileo, para observar los cuerpos celestes, mejoró el utillaje óptico, lo que le permitió un acercamiento más preciso al objeto de estudio y, en consecuencia, unos fundamentos más sólidos para su propuesta teórica. De modo similar, actualmente el desarrollo tecnológico digital ha posibilitado la extracción masiva de datos y el análisis estadístico de éstos para verificar las hipótesis de partida: la lingüística no ha podido dar el paso desde la pura especulación hacia el análisis estadístico de los hechos hasta la aparición de las tecnologías digitales.

Abstract

In most of our everyday conversations, we not only hear but also see each other talk. Our understanding of speech benefits from having the speaker's face present. This finding immediately necessitates the question of how the information from the different perceptual sources is used to reach the best overall decision. This need for processing of multiple sources of information also exists in auditory speech perception, however. Audiovisual speech simply shifts the focus from intramodal to intermodal sources but does not necessitate a qualitatively different form of processing. It is essential that a model of speech perception operationalizes the concept of processing multiple sources of information so that quantitative predictions can be made. This chapter gives an overview of the main research questions and findings unique to audiovisual speech perception and word recognition research as well as what general questions about speech perception and cognition the research in this field can answer. The main theoretical approaches to explain integration and audiovisual speech perception are introduced and critically discussed. The chapter also provides an overview of the role of visual speech as a language learning tool in multimodal training.

Abstract

This chapter is a review of the literature in experimental psycholinguistics on spoken word recognition. It is organized around eight questions. 1. Why are psycholinguists interested in spoken word recognition? 2. What information in the speech signal is used in word recognition? 3. Where are the words in the continuous speech stream? 4. Which words did the speaker intend? 5. When, as the speech signal unfolds over time, are the phonological forms of words recognized? 6. How are words recognized? 7. Whither spoken word recognition? 8. Who are the researchers in the field?

Abstract

The results of a word-spotting experiment are presented in which Dutch listeners tried to spot different types of bisyllabic Dutch words embedded in different types of nonsense contexts. Embedded verbs were not reliably harder to spot than embedded nouns; this suggests that nouns and verbs are recognised via the same basic processes. Iambic words were no harder to spot than trochaic words, suggesting that trochaic words are not in principle easier to recognise than iambic words. Words were harder to spot in consonantal contexts (i.e., contexts which themselves could not be words) than in longer contexts which contained at least one vowel (i.e., contexts which, though not words, were possible words of Dutch). A control experiment showed that this difference was not due to acoustic differences between the words in each context. The results support the claim that spoken-word recognition is sensitive to the viability of sound sequences as possible words.

Abstract

Recurrent neural networks (RNNs) have long been an architecture of interest for computational models of human sentence processing. The recently introduced Transformer architecture outperforms RNNs on many natural language processing tasks but little is known about its ability to model human language processing. We compare Transformer- and RNN-based language models’ ability to account for measures of human reading effort. Our analysis shows Transformers to outperform RNNs in explaining self-paced reading times and neural activity during reading English sentences, challenging the widely held idea that human sentence processing involves recurrent and immediate processing and provides evidence for cue-based retrieval.

Abstract

This study addresses the question whether visually grounded speech recognition (VGS) models learn to capture sentence semantics without access to any prior linguistic knowledge. We produce synthetic and natural spoken versions of a well known semantic textual similarity database and show that our VGS model produces embeddings that correlate well with human semantic similarity judgements. Our results show that a model trained on a small image-caption database outperforms two models trained on much larger databases, indicating that database size is not all that matters. We also investigate the importance of having multiple captions per image and find that this is indeed helpful even if the total number of images is lower, suggesting that paraphrasing is a valuable learning signal. While the general trend in the field is to create ever larger datasets to train models on, our findings indicate other characteristics of the database can just as important.

Abstract

Listeners use lexical knowledge to judge what speech sounds they heard. I investigated whether such lexical influences are truly top-down or just reflect a merging of perceptual and lexical constraints. This is achieved by testing whether the lexically determined identity of a phone exerts the appropriate context effects on surrounding phones. The current investigations focuses on compensation for coarticulation in vowel-fricative sequences, where the presence of a rounded vowel (/y/ rather than /i/) leads fricatives to be perceived as /s/ rather than //. This results was consistently found in all three experiments. A vowel was also more likely to be perceived as rounded /y/ if that lead listeners to be perceive words rather than nonwords (Dutch: meny, English id. vs. meni nonword). This lexical influence on the perception of the vowel had, however, no consistent influence on the perception of following fricative.