Publications

Displaying 301 - 400 of 740
  • Kempen, G. (1993). Spraakkunst als bouwkunst [Inaugural lecture]. Leiden: University of Leiden.
  • Kempen, G. (1993). Zinsontleding kan een exact vak worden. Levende Talen, 483, 459-462.
  • Kennaway, J., Glauert, J., & Zwitserlood, I. (2007). Providing Signed Content on the Internet by Synthesized Animation. ACM Transactions on Computer-Human Interaction (TOCHI), 14(3), 15. doi:10.1145/1279700.1279705.

    Abstract

    Written information is often of limited accessibility to deaf people who use sign language. The eSign project was undertaken as a response to the need for technologies enabling efficient production and distribution over the Internet of sign language content. By using an avatar-independent scripting notation for signing gestures and a client-side web browser plug-in to translate this notation into motion data for an avatar, we achieve highly efficient delivery of signing, while avoiding the inflexibility of video or motion capture. Tests with members of the deaf community have indicated that the method can provide an acceptable quality of signing.
  • Kerkhofs, R., Vonk, W., Schriefers, H., & Chwilla, D. J. (2007). Discourse, syntax, and prosody: The brain reveals an immediate interaction. Journal of Cognitive Neuroscience, 19(9), 1421-1434. doi:10.1162/jocn.2007.19.9.1421.

    Abstract

    Speech is structured into parts by syntactic and prosodic breaks. In locally syntactic ambiguous sentences, the detection of a syntactic break necessarily follows detection of a corresponding prosodic break, making an investigation of the immediate interplay of syntactic and prosodic information impossible when studying sentences in isolation. This problem can be solved, however, by embedding sentences in a discourse context that induces the expectation of either the presence or the absence of a syntactic break right at a prosodic break. Event-related potentials (ERPs) were compared to acoustically identical sentences in these different contexts. We found in two experiments that the closure positive shift, an ERP component known to be elicited by prosodic breaks, was reduced in size when a prosodic break was aligned with a syntactic break. These results establish that the brain matches prosodic information against syntactic information immediately.
  • Khemlani, S., Leslie, S.-J., Glucksberg, S., & Rubio-Fernández, P. (2007). Do ducks lay eggs? How people interpret generic assertions. In D. S. McNamara, & J. G. Trafton (Eds.), Proceedings of the 29th Annual Conference of the Cognitive Science Society (CogSci 2007). Austin, TX: Cognitive Science Society.
  • Kidd, E., Junge, C., Spokes, T., Morrison, L., & Cutler, A. (2018). Individual differences in infant speech segmentation: Achieving the lexical shift. Infancy, 23(6), 770-794. doi:10.1111/infa.12256.

    Abstract

    We report a large‐scale electrophysiological study of infant speech segmentation, in which over 100 English‐acquiring 9‐month‐olds were exposed to unfamiliar bisyllabic words embedded in sentences (e.g., He saw a wild eagle up there), after which their brain responses to either the just‐familiarized word (eagle) or a control word (coral) were recorded. When initial exposure occurs in continuous speech, as here, past studies have reported that even somewhat older infants do not reliably recognize target words, but that successful segmentation varies across children. Here, we both confirm and further uncover the nature of this variation. The segmentation response systematically varied across individuals and was related to their vocabulary development. About one‐third of the group showed a left‐frontally located relative negativity in response to familiar versus control targets, which has previously been described as a mature response. Another third showed a similarly located positive‐going reaction (a previously described immature response), and the remaining third formed an intermediate grouping that was primarily characterized by an initial response delay. A fine‐grained group‐level analysis suggested that a developmental shift to a lexical mode of processing occurs toward the end of the first year, with variation across individual infants in the exact timing of this shift.

    Additional information

    supporting information
  • Kidd, E., Donnelly, S., & Christiansen, M. H. (2018). Individual differences in language acquisition and processing. Trends in Cognitive Sciences, 22(2), 154-169. doi:10.1016/j.tics.2017.11.006.

    Abstract

    Humans differ in innumerable ways, with considerable variation observable at every level of description, from the molecular to the social. Traditionally, linguistic and psycholinguistic theory has downplayed the possibility of meaningful differences in language across individuals. However, it is becoming increasingly evident that there is
    significant variation among speakers at any age as well as across the lifespan. In this paper, we review recent research in psycholinguistics, and argue that a focus on individual differences provides a crucial source of evidence that bears strongly upon core issues in theories of the acquisition and processing of language; specifically, the role of experience in language acquisition, processing, and attainment, and the architecture of the language faculty.
  • Kidd, E., & Bavin, E. L. (2007). Lexical and referential influences on on-line spoken language comprehension: A comparison of adults and primary-school-age children. First Language, 27(1), 29-52. doi:10.1177/0142723707067437.

    Abstract

    This paper reports on two studies investigating children's and adults' processing of sentences containing ambiguity of prepositional phrase (PP) attachment. Study 1 used corpus data to investigate whether cues argued to be used by adults to resolve PP-attachment ambiguities are available in child-directed speech. Study 2 was an on-line reaction time study investigating the role of lexical and referential biases in syntactic ambiguity resolution by children and adults. Forty children (mean age 8;4) and 37 adults listened to V-NP-PP sentences containing temporary ambiguity of PP-attachment. The sentences were manipulated for (i) verb semantics, (ii) the definiteness of the object NP, and (iii) PP-attachment site. The children and adults did not differ qualitatively from each other in their resolution of the ambiguity. A verb semantics by attachment interaction suggested that different attachment analyses were pursued depending on the semantics of the verb. There was no influence of the definiteness of the object NP in either children's or adults' parsing preferences. The findings from the on-line task matched up well with the corpus data, thus identifying a role for the input in the development of parsing strategies.
  • Kidd, E., Brandt, S., Lieven, E., & Tomasello, M. (2007). Object relatives made easy: A cross-linguistic comparison of the constraints influencing young children's processing of relative clauses. Language and Cognitive Processes, 22(6), 860-897. doi:10.1080/01690960601155284.

    Abstract

    We present the results from four studies, two corpora and two experimental, which suggest that English- and German-speaking children (3;1–4;9 years) use multiple constraints to process and produce object relative clauses. Our two corpora studies show that children produce object relatives that reflect the distributional and discourse regularities of the input. Specifically, the results show that when children produce object relatives they most often do so with (a) an inanimate head noun, and (b) a pronominal relative clause subject. Our experimental findings show that children use these constraints to process and produce this construction type. Moreover, when children were required to repeat the object relatives they most often use in naturalistic speech, the subject-object asymmetry in processing of relative clauses disappeared. We also report cross-linguistic differences in children's rate of acquisition which reflect properties of the input language. Overall, our results suggest that children are sensitive to the same constraints on relative clause processing as adults.
  • Kirsch, J. (2018). Listening for the WHAT and the HOW: Older adults' processing of semantic and affective information in speech. PhD Thesis, Radboud University Nijmegen, Nijmegen.
  • Kita, S., Ozyurek, A., Allen, S., Brown, A., Furman, R., & Ishizuka, T. (2007). Relations between syntactic encoding and co-speech gestures: Implications for a model of speech and gesture production. Language and Cognitive Processes, 22(8), 1212-1236. doi:10.1080/01690960701461426.

    Abstract

    Gestures that accompany speech are known to be tightly coupled with speech production. However little is known about the cognitive processes that underlie this link. Previous cross-linguistic research has provided preliminary evidence for online interaction between the two systems based on the systematic co-variation found between how different languages syntactically package Manner and Path information of a motion event and how gestures represent Manner and Path. Here we elaborate on this finding by testing whether speakers within the same language gesturally express Manner and Path differently according to their online choice of syntactic packaging of Manner and Path, or whether gestural expression is pre-determined by a habitual conceptual schema congruent with the linguistic typology. Typologically congruent and incongruent syntactic structures for expressing Manner and Path (i.e., in a single clause or multiple clauses) were elicited from English speakers. We found that gestural expressions were determined by the online choice of syntactic packaging rather than by a habitual conceptual schema. It is therefore concluded that speech and gesture production processes interface online at the conceptual planning phase. Implications of the findings for models of speech and gesture production are discussed
  • Kita, S., & Ozyurek, A. (2007). How does spoken language shape iconic gestures? In S. Duncan, J. Cassel, & E. Levy (Eds.), Gesture and the dynamic dimension of language (pp. 67-74). Amsterdam: Benjamins.
  • Kiyama, S., Verdonschot, R. G., Xiong, K., & Tamaoka, K. (2018). Individual mentalizing ability boosts flexibility toward a linguistic marker of social distance: An ERP investigation. Journal of Neurolinguistics, 47, 1-15. doi:10.1016/j.jneuroling.2018.01.005.

    Abstract

    Sentence-final particles (SFPs) as bound morphemes in Japanese have no obvious effect on the truth conditions of a sentence. However, they encompass a diverse range of usages, from typical to atypical, according to the context and the interpersonal relationships in the specific situation. The most frequent particle,-ne, is typically used after addressee-oriented propositions for information sharing, while another frequent particle,-yo, is typically used after addresser-oriented propositions to elicit a sense of strength. This study sheds light on individual differences among native speakers in flexibly understanding such linguistic markers based on their mentalizing ability (i.e., the ability to infer the mental states of others). Two experiments employing electroencephalography (EEG) consistently showed enhanced early posterior negativities (EPN) for atypical SFP usage compared to typical usage, especially when understanding-ne compared to -yo, in both an SFP appropriateness judgment task and a content comprehension task. Importantly, the amplitude of the EPN for atypical usages of-ne was significantly higher in participants with lower mentalizing ability than in those with a higher mentalizing ability. This effect plausibly reflects low-ability mentalizers' stronger sense of strangeness toward atypical-ne usage. While high-ability mentalizers may aptly perceive others' attitudes via their various usages of-ne, low-ability mentalizers seem to adopt a more stereotypical understanding. These results attest to the greater degree of difficulty low-ability mentalizers have in establishing a smooth regulation of interpersonal distance during social encounters.

    Additional information

    stimuli dialog sets
  • Klaas, G. (2007). Hints and recommendations concerning field equipment. In A. Majid (Ed.), Field manual volume 10 (pp. 5-6). Nijmegen: Max Planck Institute for Psycholinguistics.
  • Klein, W., & Von Stutterheim, C. (Eds.). (2007). Sprachliche Perspektivierung [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, 145.
  • Klein, W. (2007). Zwei Leitgedanken zu "Sprache und Erkenntnis". Zeitschrift für Literaturwissenschaft und Linguistik, 145, 9-43.

    Abstract

    In a way, the entire history of linguistic thought from the Antiquity to present days is a series of variations on two key themes: 1. In a certain sense, language and cognition are the same, and 2. In a certain sense, all languages are the same. What varies is the way in which “in a certain sense” is spelled out. Interpretations oscillate between radical positions such as the idea that thinking without speaking is impossible to the idea that it is just language which vexes our cognition and hence makes it rather impossible, and similarly between the idea that all differences between natural languages are nothing but irrelevant variations in the “vox”, the “external form” to the idea that it our thought is massively shaped by the particular structural features of the language we happen to speak. It is remarkable how little agreement has been reached on these issues after more than 2500 years of discussion. This, it is argued, has mainly two reasons: (a) The entire argument is largely confined to a few lexical and morphological properties of human languages, and (b) the discussion is rarely based on empirical research on “language at work” - how do we manage to solve those many little tasks for which human languages are designed in the first place.
  • Klein, W. (1993). Ellipse. In J. Jacobs, A. von Stechow, W. Sternefeld, & T. Vennemann (Eds.), Syntax: Ein internationales Handbuch zeitgenössischer Forschung [1. Halbband] (pp. 763-799). Berlin: de Gruyter.
  • Klein, W., & Von Stutterheim, C. (2007). Einführung. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, (145), 5-8.
  • Klein, W. (2007). Mechanismen des Erst- und Zweitspracherwerbs = Mechanisms of First and Second Language Acquisition. Sprache Stimme Gehör, 31, 138-143. doi:10.1055/s-2007-985818.

    Abstract

    Language acquisition is the transition between the language faculty, with which we are born as a part of our genetic endowment, to the mastery of one or more linguistic systems. There is a plethora of findings about this process; but these findings still do not form a coherent picture of the principles which underlie this process. There are at least six reasons for this situation. First, there is an enormous variability in the conditions under which this process occurs. Second, the learning capacity does not remain constant over time. Third, the process extends over many years and is therefore hard to study. Fourth, especially the investigation of the meaning side is problem-loaded. Fifth, many skills and types of knowledge must be learned in a more or less synchronised way. And sixth, our understanding of the functioning of linguistic systems is still very limited. Nevertheless, there are a few overarching results, three of which are discussed here: (1) There are salient differences between child and adult learners: While children normally end up with perfect mastery of the language to be learned, this is hardly ever the case for adults. On the hand, it could be shown for each linguistic property examined so far, that adults are in principle able to learn it up to perfection. So, adults can learn everything perfectly well, they just don’t. (2) Within childhood, age of onset plays no essential role for ultimate attainment. (3) Children care much more for formal correctness than adults - they are just better in mimicking existing systems. It is argued that age does not affect the „construction capacity”- the capacity to build up linguistic systems - but the „copying faculty”, i.e., the faculty to imitate an existing system.
  • Klein, W. (1993). L'Expression de la spatialité dans le langage humain. In M. Denis (Ed.), Images et langages (pp. 73-85). Paris: CNRS.
  • Klein, W. (1993). Learner varieties and theoretical linguistics. In C. Perdue (Ed.), Adult language acquisition: Cross-linguistic perspectives. Cambridge: Cambridge University Press.
  • Klein, W. (2018). Looking at language. Berlin: De Gruyter.

    Abstract

    The volume presents an essential selection collected from the essays of Wolfgang Klein. In addition to journal and book articles, many of them published by Mouton, this book features new and unpublished texts by the author. It focuses, among other topics, on information structure, the expression of grammatical categories and the structure of learner varieties.
  • Klein, W. (1993). Some notorious pitfalls in the analysis of spatial expressions. In F. Beckman, & G. Heyer (Eds.), Theorie und Praxis des Lexikons (pp. 191-204). Berlin: de Gruyter.
  • Klein, W. (1993). Wie ist der Stand der germanistischen Sprachwissenschaft, und was können wir tun, um ihn zu verbessern? Zeitschrift für Literaturwissenschaft und Linguistik, 90/91, 40-52.
  • Klein, W., & Perdue, C. (1993). Utterance structure. In C. Perdue (Ed.), Adult language acquisition: Cross-linguistic perspectives: Vol. 2 The results (pp. 3-40). Cambridge: Cambridge University Press.
  • Koch, X. (2018). Age and hearing loss effects on speech processing. PhD Thesis, Radboud University Nijmegen, Nijmegen.
  • Kochari, A. R., & Ostarek, M. (2018). Introducing a replication-first rule for PhD projects (commmentary on Zwaan et al., ‘Making replication mainstream’). Behavioral and Brain Sciences, 41: e138. doi:10.1017/S0140525X18000730.

    Abstract

    Zwaan et al. mention that young researchers should conduct replications as a
    small part of their portfolio. We extend this proposal and suggest that conducting and
    reporting replications should become an integral part of PhD projects and be taken into
    account in their assessment. We discuss how this would help not only scientific
    advancement, but also PhD candidates’ careers.
  • Kolipakam, V. (2018). A holistic approach to understanding pre-history. PhD Thesis, Radboud University Nijmegen, Nijmegen.
  • Kolipakam, V., Jordan, F., Dunn, M., Greenhill, S. J., Bouckaert, R., Gray, R. D., & Verkerk, A. (2018). A Bayesian phylogenetic study of the Dravidian language family. Royal Society Open Science, 5: 171504. doi:10.1098/rsos.171504.

    Abstract

    The Dravidian language family consists of about 80 varieties (Hammarström H. 2016 Glottolog 2.7) spoken by 220 million people across southern and central India and surrounding countries (Steever SB. 1998 In The Dravidian languages (ed. SB Steever), pp. 1–39: 1). Neither the geographical origin of the Dravidian language homeland nor its exact dispersal through time are known. The history of these languages is crucial for understanding prehistory in Eurasia, because despite their current restricted range, these languages played a significant role in influencing other language groups including Indo-Aryan (Indo-European) and Munda (Austroasiatic) speakers. Here, we report the results of a Bayesian phylogenetic analysis of cognate-coded lexical data, elicited first hand from native speakers, to investigate the subgrouping of the Dravidian language family, and provide dates for the major points of diversification. Our results indicate that the Dravidian language family is approximately 4500 years old, a finding that corresponds well with earlier linguistic and archaeological studies. The main branches of the Dravidian language family (North, Central, South I, South II) are recovered, although the placement of languages within these main branches diverges from previous classifications. We find considerable uncertainty with regard to the relationships between the main branches.
  • Kong, X., Mathias, S. R., Guadalupe, T., ENIGMA Laterality Working Group, Glahn, D. C., Franke, B., Crivello, F., Tzourio-Mazoyer, N., Fisher, S. E., Thompson, P. M., & Francks, C. (2018). Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium. Proceedings of the National Academy of Sciences of the United States of America, 115(22), E5154-E5163. doi:10.1073/pnas.1718418115.

    Abstract

    Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here the ENIGMA consortium presents the largest ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (N = 1,443 and 1,113, respectively), we found several asymmetries showing significant, replicable heritability. The structural asymmetries identified, and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders.

    Additional information

    pnas.1718418115.sapp.pdf
  • Hu, C.-P., Kong, X., Wagenmakers, E.-J., Ly, A., & Peng, K. (2018). The Bayes factor and its implementation in JASP: A practical primer. Advances in Psychological Science, 26(6), 951-965. doi:10.3724/SP.J.1042.2018.00951.

    Abstract

    Statistical inference plays a critical role in modern scientific research, however, the dominant method for statistical inference in science, null hypothesis significance testing (NHST), is often misunderstood and misused, which leads to unreproducible findings. To address this issue, researchers propose to adopt the Bayes factor as an alternative to NHST. The Bayes factor is a principled Bayesian tool for model selection and hypothesis testing, and can be interpreted as the strength for both the null hypothesis H0 and the alternative hypothesis H1 based on the current data. Compared to NHST, the Bayes factor has the following advantages: it quantifies the evidence that the data provide for both the H0 and the H1, it is not “violently biased” against H0, it allows one to monitor the evidence as the data accumulate, and it does not depend on sampling plans. Importantly, the recently developed open software JASP makes the calculation of Bayes factor accessible for most researchers in psychology, as we demonstrated for the t-test. Given these advantages, adopting the Bayes factor will improve psychological researchers’ statistical inferences. Nevertheless, to make the analysis more reproducible, researchers should keep their data analysis transparent and open.
  • Konopka, A., Meyer, A. S., & Forest, T. A. (2018). Planning to speak in L1 and L2. Cognitive Psychology, 102, 72-104. doi:10.1016/j.cogpsych.2017.12.003.

    Abstract

    The leading theories of sentence planning – Hierarchical Incrementality and Linear Incrementality – differ in their assumptions about the coordination of processes that map preverbal information onto language. Previous studies showed that, in native (L1) speakers, this coordination can vary with the ease of executing the message-level and sentence-level processes necessary to plan and produce an utterance. We report the first series of experiments to systematically examine how linguistic experience influences sentence planning in native (L1) speakers (i.e., speakers with life-long experience using the target language) and non-native (L2) speakers (i.e., speakers with less experience using the target language). In all experiments, speakers spontaneously generated one-sentence descriptions of simple events in Dutch (L1) and English (L2). Analyses of eye-movements across early and late time windows (pre- and post-400 ms) compared the extent of early message-level encoding and the onset of linguistic encoding. In Experiment 1, speakers were more likely to engage in extensive message-level encoding and to delay sentence-level encoding when using their L2. Experiments 2–4 selectively facilitated encoding of the preverbal message, encoding of the agent character (i.e., the first content word in active sentences), and encoding of the sentence verb (i.e., the second content word in active sentences) respectively. Experiment 2 showed that there is no delay in the onset of L2 linguistic encoding when speakers are familiar with the events. Experiments 3 and 4 showed that the delay in the onset of L2 linguistic encoding is not due to speakers delaying encoding of the agent, but due to a preference to encode information needed to select a suitable verb early in the formulation process. Overall, speakers prefer to temporally separate message-level from sentence-level encoding and to prioritize encoding of relational information when planning L2 sentences, consistent with Hierarchical Incrementality
  • Kooijman, V. (2007). Continuous-speech segmentation at the beginning of language acquisition: Electrophysiological evidence. PhD Thesis, Radboud University Nijmegen, Nijmegen.

    Abstract

    Word segmentation, or detecting word boundaries in continuous speech, is not an easy task. Spoken language does not contain silences to indicate word boundaries and words partly overlap due to coarticalution. Still, adults listening to their native language perceive speech as individual words. They are able to combine different distributional cues in the language, such as the statistical distribution of sounds and metrical cues, with lexical information, to efficiently detect word boundaries. Infants in the first year of life do not command these cues. However, already between seven and ten months of age, before they know word meaning, infants learn to segment words from speech. This important step in language acquisition is the topic of this dissertation. In chapter 2, the first Event Related Brain Potential (ERP) study on word segmentation in Dutch ten-month-olds is discussed. The results show that ten-month-olds can already segment words with a strong-weak stress pattern from speech and they need roughly the first half of a word to do so. Chapter 3 deals with segmentation of words beginning with a weak syllable, as a considerable number of words in Dutch do not follow the predominant strong-weak stress pattern. The results show that ten-month-olds still largely rely on the strong syllable in the language, and do not show an ERP response to the initial weak syllable. In chapter 4, seven-month-old infants' segmentation of strong-weak words was studied. An ERP response was found to strong-weak words presented in sentences. However, a behavioral response was not found in an additional Headturn Preference Procedure study. There results suggest that the ERP response is a precursor to the behavioral response that infants show at a later age.

    Additional information

    full text via Radboud Repository
  • Korvorst, M., Roelofs, A., & Levelt, W. J. M. (2007). Telling time from analog and digital clocks: A multiple-route account. Experimental Psychology, 54(3), 187-191. doi:10.1027/1618-3169.54.3.187.

    Abstract

    Does the naming of clocks always require conceptual preparation? To examine this question, speakers were presented with analog and digital clocks that had to be named in Dutch using either a relative (e.g., “quarter to four”) or an absolute (e.g., “three forty-five”) clock time expression format. Naming latencies showed evidence of conceptual preparation when speakers produced relative time expressions to analog and digital clocks, but not when they used absolute time expressions. These findings indicate that conceptual mediation is not always mandatory for telling time, but instead depends on clock time expression format, supporting a multiple-route account of Dutch clock time naming.
  • Kösem, A., Bosker, H. R., Takashima, A., Meyer, A. S., Jensen, O., & Hagoort, P. (2018). Neural entrainment determines the words we hear. Current Biology, 28, 2867-2875. doi:10.1016/j.cub.2018.07.023.

    Abstract

    Low-frequency neural entrainment to rhythmic input
    has been hypothesized as a canonical mechanism
    that shapes sensory perception in time. Neural
    entrainment is deemed particularly relevant for
    speech analysis, as it would contribute to the extraction
    of discrete linguistic elements from continuous
    acoustic signals. However, its causal influence in
    speech perception has been difficult to establish.
    Here, we provide evidence that oscillations build temporal
    predictions about the duration of speech tokens
    that affect perception. Using magnetoencephalography
    (MEG), we studied neural dynamics during
    listening to sentences that changed in speech rate.
    Weobserved neural entrainment to preceding speech
    rhythms persisting for several cycles after the change
    in rate. The sustained entrainment was associated
    with changes in the perceived duration of the last
    word’s vowel, resulting in the perception of words
    with different meanings. These findings support oscillatory
    models of speech processing, suggesting that
    neural oscillations actively shape speech perception.
  • Kotz, S. A., Ravignani, A., & Fitch, W. T. (2018). The evolution of rhythm processing. Trends in Cognitive Sciences, 22(10), 896-910. doi:10.1016/j.tics.2018.08.002.
  • Kouwenhoven, H., Van Mulken, M., & Ernestus, M. (2018). Communication strategy use by Spanish speakers of English in formal and informal speech. International Journal of Bilingualism, 22(3), 285-305. doi:10.1177/1367006916672946.

    Abstract

    Research questions:

    Are emergent bilinguals sensitive to register variation in their use of communication strategies? What strategies do LX speakers, in casu Spanish speakers of English, use as a function of situational context? What role do individual differences play?
    Methodology:

    This within-speaker study compares Spanish second-language English speakers’ communication strategy use in an informal, peer-to-peer conversation and a formal interview.
    Data and analysis:

    The 15 hours of informal and 9.5 hours of formal speech from the Nijmegen Corpus of Spanish English were coded for 19 different communication strategies.
    Findings/conclusions:

    Overall, speakers prefer self-reliant strategies, which allow them to continue communication without their interlocutor’s help. Of the self-reliant strategies, least effort strategies such as code-switching are used more often in informal speech, whereas relatively more effortful strategies (e.g. reformulations) are used more in informal speech, when the need to be unambiguously understood is felt as more important. Individual differences played a role: some speakers were more affected by a change in formality than others.
    Originality:

    Sensitivity to register variation has not yet been studied within communicative strategy use.
    Implications:

    General principles of communication govern speakers’ strategy selection, notably the protection of positive face and the least effort and cooperative principles.

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  • Kouwenhoven, H., Ernestus, M., & Van Mulken, M. (2018). Register variation by Spanish users of English. The Nijmegen Corpus of Spanish English. Corpus Linguistics and Linguistic Theory, 14(1), 35-63. doi:10.1515/cllt-2013-0054.

    Abstract

    English serves as a lingua franca in situations with varying degrees of
    formality. How formality affects non-native speech has rarely been studied. We
    investigated register variation by Spanish users of English by comparing formal
    and informal speech from the Nijmegen Corpus of Spanish English that we
    created. This corpus comprises speech from thirty-four Spanish speakers of
    English in interaction with Dutch confederates in two speech situations.
    Formality affected the amount of laughter and overlapping speech and the
    number of Spanish words. Moreover, formal speech had a more informational
    character than informal speech. We discuss how our findings relate to register
    variation in Spanish

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  • De Kovel, C. G. F., & Fisher, S. E. (2018). Molecular genetic methods. In A. M. B. De Groot, & P. Hagoort (Eds.), Research methods in psycholinguistics and the neurobiology of language: A practical guide (pp. 330-353). Hoboken: Wiley.
  • De Kovel, C. G. F., Lisgo, S. N., Fisher, S. E., & Francks, C. (2018). Subtle left-right asymmetry of gene expression profiles in embryonic and foetal human brains. Scientific Reports, 8: 12606. doi:10.1038/s41598-018-29496-2.

    Abstract

    Left-right laterality is an important aspect of human –and in fact all vertebrate– brain organization for which the genetic basis is poorly understood. Using RNA sequencing data we contrasted gene expression in left- and right-sided samples from several structures of the anterior central nervous systems of post mortem human embryos and foetuses. While few individual genes stood out as significantly lateralized, most structures showed evidence of laterality of their overall transcriptomic profiles. These left-right differences showed overlap with age-dependent changes in expression, indicating lateralized maturation rates, but not consistently in left-right orientation over all structures. Brain asymmetry may therefore originate in multiple locations, or if there is a single origin, it is earlier than 5 weeks post conception, with structure-specific lateralized processes already underway by this age. This pattern is broadly consistent with the weak correlations reported between various aspects of adult brain laterality, such as language dominance and handedness.
  • De Kovel, C. G. F., Lisgo, S. N., & Francks, C. (2018). Transcriptomic analysis of left-right differences in human embryonic forebrain and midbrain. Scientific Data, 5: 180164. doi:10.1038/sdata.2018.164.

    Abstract

    Left-right asymmetry is subtle but pervasive in the human central nervous system. This asymmetry is initiated early during development, but its mechanisms are poorly known. Forebrains and midbrains were dissected from six human embryos at Carnegie stages 15 or 16, one of which was female. The structures were divided into left and right sides, and RNA was isolated. RNA was sequenced with 100 base-pair paired ends using Illumina Hiseq 4000. After quality control, five paired brain sides were available for midbrain and forebrain. A paired analysis between left- and right sides of a given brain structure across the embryos identified left-right differences. The dataset, consisting of Fastq files and a read count table, can be further used to study early development of the human brain
  • Kristiansen, M., Deriziotis, P., Dimcheff, D. E., Jackson, G. S., Ovaa, H., Naumann, H., Clarke, A. R., van Leeuwen, F. W., Menéndez-Benito, V., Dantuma, N. P., Portis, J. L., Collinge, J., & Tabrizi, S. J. (2007). Disease-associated prion protein oligomers inhibit the 26S proteasome. Molecular Cell, 26, 175-188. doi:10.1016/j.molcel.2007.04.001.

    Abstract

    * Kristiansen, M., Deriziotis, P. These authors contributed equally to this work.* - The mechanism of cell death in prion disease is unknown but is associated with the production of a misfolded conformer of the prion protein. We report that disease-associated prion protein specifically inhibits the proteolytic β subunits of the 26S proteasome. Using reporter substrates, fluorogenic peptides, and an activity probe for the β subunits, this inhibitory effect was demonstrated in pure 26S proteasome and three different cell lines. By challenge with recombinant prion and other amyloidogenic proteins, we demonstrate that only the prion protein in a nonnative β sheet conformation inhibits the 26S proteasome at stoichiometric concentrations. Preincubation with an antibody specific for aggregation intermediates abrogates this inhibition, consistent with an oligomeric species mediating this effect. We also present evidence for a direct relationship between prion neuropathology and impairment of the ubiquitin-proteasome system (UPS) in prion-infected UPS-reporter mice. Together, these data suggest a mechanism for intracellular neurotoxicity mediated by oligomers of misfolded prion protein.

    Additional information

    MolCellSup.pdf
  • Kuerbitz, J., Arnett, M., Ehrman, S., Williams, M. T., Voorhees, C. V., Fisher, S. E., Garratt, A. N., Muglia, L. J., Waclaw, R. R., & Campbell, K. (2018). Loss of intercalated cells (ITCs) in the mouse amygdala of Tshz1 mutants correlates with fear, depression and social interaction phenotypes. The Journal of Neuroscience, 38, 1160-1177. doi:10.1523/JNEUROSCI.1412-17.2017.

    Abstract

    The intercalated cells (ITCs) of the amygdala have been shown to be critical regulatory components of amygdalar circuits, which control appropriate fear responses. Despite this, the molecular processes guiding ITC development remain poorly understood. Here we establish the zinc finger transcription factor Tshz1 as a marker of ITCs during their migration from the dorsal lateral ganglionic eminence through maturity. Using germline and conditional knock-out (cKO) mouse models, we show that Tshz1 is required for the proper migration and differentiation of ITCs. In the absence of Tshz1, migrating ITC precursors fail to settle in their stereotypical locations encapsulating the lateral amygdala and BLA. Furthermore, they display reductions in the ITC marker Foxp2 and ectopic persistence of the dorsal lateral ganglionic eminence marker Sp8. Tshz1 mutant ITCs show increased cell death at postnatal time points, leading to a dramatic reduction by 3 weeks of age. In line with this, Foxp2-null mutants also show a loss of ITCs at postnatal time points, suggesting that Foxp2 may function downstream of Tshz1 in the maintenance of ITCs. Behavioral analysis of male Tshz1 cKOs revealed defects in fear extinction as well as an increase in floating during the forced swim test, indicative of a depression-like phenotype. Moreover, Tshz1 cKOs display significantly impaired social interaction (i.e., increased passivity) regardless of partner genetics. Together, these results suggest that Tshz1 plays a critical role in the development of ITCs and that fear, depression-like and social behavioral deficits arise in their absence. SIGNIFICANCE STATEMENT We show here that the zinc finger transcription factor Tshz1 is expressed during development of the intercalated cells (ITCs) within the mouse amygdala. These neurons have previously been shown to play a crucial role in fear extinction. Tshz1 mouse mutants exhibit severely reduced numbers of ITCs as a result of abnormal migration, differentiation, and survival of these neurons. Furthermore, the loss of ITCs in mouse Tshz1 mutants correlates well with defects in fear extinction as well as the appearance of depression-like and abnormal social interaction behaviors reminiscent of depressive disorders observed in human patients with distal 18q deletions, including the Tshz1 locus.
  • Kuiper, K., Van Egmond, M.-E., Kempen, G., & Sprenger, S. A. (2007). Slipping on superlemmas: Multiword lexical items in speech production. The Mental Lexicon, 2(3), 313-357.

    Abstract

    Only relatively recently have theories of speech production concerned themselves with the part idioms and other multi-word lexical items (MLIs) play in the processes of speech production. Two theories of speech production which attempt to account for the accessing of idioms in speech production are those of Cutting and Bock (1997) and superlemma theory (Sprenger, 2003; Sprenger, Levelt, & Kempen, 2006). Much of the data supporting theories of speech production comes either from time course experiments or from slips of the tongue (Bock & Levelt, 1994). The latter are of two kinds: experimentally induced (Baars, 1992) or naturally observed (Fromkin, 1980). Cutting and Bock use experimentally induced speech errors while Sprenger et al. use time course experiments. The missing data type that has a bearing on speech production involving MLIs is that of naturally occurring slips. In this study the impact of data taken from naturally observed slips involving English and Dutch MLIs are brought to bear on these theories. The data are taken initially from a corpus of just over 1000 naturally observed English slips involving MLIs (the Tuggy corpus). Our argument proceeds as follows. First we show that slips occur independent of whether or not there are MLIs involved. In other words, speech production proceeds in certain of its aspects as though there were no MLI present. We illustrate these slips from the Tuggy data. Second we investigate the predictions of superlemma theory. Superlemma theory (Sprenger et al., 2006) accounts for the selection of MLIs and how their properties enter processes of speech production. It predicts certain activation patterns dependent on a MLI being selected. Each such pattern might give rise to slips of the tongue. This set of predictions is tested against the Tuggy data. Each of the predicted activation patterns yields a significant number of slips. These findings are therefore compatible with a view of MLIs as single units in so far as their activation by lexical concepts goes. However, the theory also predicts that some slips are likely not to occur. We confirm that such slips are not present in the data. These findings are further corroborated by reference a second smaller dataset of slips involving Dutch MLIs (the Kempen corpus). We then use slips involving irreversible binomials to distinguish between the predictions of superlemma theory which are supported by slips involving irreversible binomials and the Cutting and Bock model's predictions for slips involving these MLIs which are not
  • Kung, C. (2018). Speech comprehension in a tone language: The role of lexical tone, context, and intonation in Cantonese-Chinese. PhD Thesis, Radboud University Nijmegen, Nijmegen.
  • Kuperman, V., Pluymaekers, M., Ernestus, M., & Baayen, R. H. (2007). Morphological predictability and acoustic duration of interfixes in Dutch compounds. Journal of the Acoustical Society of America, 121(4), 2261-2271. doi:10.1121/1.2537393.

    Abstract

    This study explores the effects of informational redundancy, as carried by a word's morphological paradigmatic structure, on acoustic duration in read aloud speech. The hypothesis that the more predictable a linguistic unit is, the less salient its realization, was tested on the basis of the acoustic duration of interfixes in Dutch compounds in two datasets: One for the interfix -s- (1155 tokens) and one for the interfix -e(n)- (742 tokens). Both datasets show that the more probable the interfix is, given the compound and its constituents, the longer it is realized. These findings run counter to the predictions of information-theoretical approaches and can be resolved by the Paradigmatic Signal Enhancement Hypothesis. This hypothesis argues that whenever selection of an element from alternatives is probabilistic, the element's duration is predicted by the amount of paradigmatic support for the element: The most likely alternative in the paradigm of selection is realized longer.
  • Kuzla, C., & Ernestus, M. (2007). Prosodic conditioning of phonetic detail of German plosives. In J. Trouvain, & W. J. Barry (Eds.), Proceedings of the 16th International Congress of Phonetic Sciences (ICPhS 2007) (pp. 461-464). Dudweiler: Pirrot.

    Abstract

    The present study investigates the influence of prosodic structure on the fine-grained phonetic details of German plosives which also cue the phonological fortis-lenis contrast. Closure durations were found to be longer at higher prosodic boundaries. There was also less glottal vibration in lenis plosives at higher prosodic boundaries. Voice onset time in lenis plosives was not affected by prosody. In contrast, for the fortis plosives VOT decreased at higher boundaries, as did the maximal intensity of the release. These results demonstrate that the effects of prosody on different phonetic cues can go into opposite directions, but are overall constrained by the need to maintain phonological contrasts. While prosodic effects on some cues are compatible with a ‘fortition’ account of prosodic strengthening or with a general feature enhancement explanation, the effects on others enhance paradigmatic contrasts only within a given prosodic position.
  • Kuzla, C., Cho, T., & Ernestus, M. (2007). Prosodic strengthening of German fricatives in duration and assimilatory devoicing. Journal of Phonetics, 35(3), 301-320. doi:10.1016/j.wocn.2006.11.001.

    Abstract

    This study addressed prosodic effects on the duration of and amount of glottal vibration in German word-initial fricatives /f, v, z/ in assimilatory and non-assimilatory devoicing contexts. Fricatives following /small schwa/ (non-assimilation context) were longer and were produced with less glottal vibration after higher prosodic boundaries, reflecting domain-initial prosodic strengthening. After /t/ (assimilation context), lenis fricatives (/v, z/) were produced with less glottal vibration than after /small schwa/, due to assimilatory devoicing. This devoicing was especially strong across lower prosodic boundaries, showing the influence of prosodic structure on sandhi processes. Reduction in glottal vibration made lenis fricatives more fortis-like (/f, s/). Importantly, fricative duration, another major cue to the fortis-lenis distinction, was affected by initial lengthening, but not by assimilation. Hence, at smaller boundaries, fricatives were more devoiced (more fortis-like), but also shorter (more lenis-like). As a consequence, the fortis and lenis fricatives remained acoustically distinct in all prosodic and segmental contexts. Overall, /z/ was devoiced to a greater extent than /v/. Since /z/ does not have a fortis counterpart in word-initial position, these findings suggest that phonotactic restrictions constrain phonetic processes. The present study illuminates a complex interaction of prosody, sandhi processes, and phonotactics, yielding systematic phonetic cues to prosodic structure and phonological distinctions.
  • Lai, V. T., Chang, M., Duffield, C., Hwang, J., Xue, N., & Palmer, M. (2007). Defining a methodology for mapping Chinese and English sense inventories. In Proceedings of the 8th Chinese Lexical Semantics Workshop 2007 (CLSW 2007). The Hong Kong Polytechnic University, Hong Kong, May 21-23 (pp. 59-65).

    Abstract

    In this study, we explored methods for linking Chinese and English sense inventories using two opposing approaches: creating links (1) bottom-up: by starting at the finer-grained sense level then proceeding to the verb subcategorization frames and (2) top-down: by starting directly with the more coarse-grained frame levels. The sense inventories for linking include pre-existing corpora, such as English Propbank (Palmer, Gildea, and Kingsbury, 2005), Chinese Propbank (Xue and Palmer, 2004) and English WordNet (Fellbaum, 1998) and newly created corpora, the English and Chinese Sense Inventories from DARPA-GALE OntoNotes. In the linking task, we selected a group of highly frequent and polysemous communication verbs, including say, ask, talk, and speak in English, and shuo, biao-shi, jiang, and wen in Chinese. We found that with the bottom-up method, although speakers of both languages agreed on the links between senses, the subcategorization frames of the corresponding senses did not match consistently. With the top-down method, if the verb frames match in both languages, their senses line up more quickly to each other. The results indicate that the top-down method is more promising in linking English and Chinese sense inventories.
  • Lakens, D., Adolfi, F. G., Albers, C. J., Anvari, F., Apps, M. A. J., Argamon, S. E., Baguley, T., Becker, R. B., Benning, S. D., Bradford, D. E., Buchanan, E. M., Caldwell, A. R., Van Calster, B., Carlsson, R., Chen, S.-C., Chung, B., Colling, L. J., Collins, G. S., Crook, Z., Cross, E. S. and 68 moreLakens, D., Adolfi, F. G., Albers, C. J., Anvari, F., Apps, M. A. J., Argamon, S. E., Baguley, T., Becker, R. B., Benning, S. D., Bradford, D. E., Buchanan, E. M., Caldwell, A. R., Van Calster, B., Carlsson, R., Chen, S.-C., Chung, B., Colling, L. J., Collins, G. S., Crook, Z., Cross, E. S., Daniels, S., Danielsson, H., DeBruine, L., Dunleavy, D. J., Earp, B. D., Feist, M. I., Ferrelle, J. D., Field, J. G., Fox, N. W., Friesen, A., Gomes, C., Gonzalez-Marquez, M., Grange, J. A., Grieve, A. P., Guggenberger, R., Grist, J., Van Harmelen, A.-L., Hasselman, F., Hochard, K. D., Hoffarth, M. R., Holmes, N. P., Ingre, M., Isager, P. M., Isotalus, H. K., Johansson, C., Juszczyk, K., Kenny, D. A., Khalil, A. A., Konat, B., Lao, J., Larsen, E. G., Lodder, G. M. A., Lukavský, J., Madan, C. R., Manheim, D., Martin, S. R., Martin, A. E., Mayo, D. G., McCarthy, R. J., McConway, K., McFarland, C., Nio, A. Q. X., Nilsonne, G., De Oliveira, C. L., De Xivry, J.-J.-O., Parsons, S., Pfuhl, G., Quinn, K. A., Sakon, J. J., Saribay, S. A., Schneider, I. K., Selvaraju, M., Sjoerds, Z., Smith, S. G., Smits, T., Spies, J. R., Sreekumar, V., Steltenpohl, C. N., Stenhouse, N., Świątkowski, W., Vadillo, M. A., Van Assen, M. A. L. M., Williams, M. N., Williams, S. E., Williams, D. R., Yarkoni, T., Ziano, I., & Zwaan, R. A. (2018). Justify your alpha. Nature Human Behaviour, 2, 168-171. doi:10.1038/s41562-018-0311-x.

    Abstract

    In response to recommendations to redefine statistical significance to P ≤ 0.005, we propose that researchers should transparently report and justify all choices they make when designing a study, including the alpha level.
  • Lam, N. H. L., Hulten, A., Hagoort, P., & Schoffelen, J.-M. (2018). Robust neuronal oscillatory entrainment to speech displays individual variation in lateralisation. Language, Cognition and Neuroscience, 33(8), 943-954. doi:10.1080/23273798.2018.1437456.

    Abstract

    Neural oscillations may be instrumental for the tracking and segmentation of continuous speech. Earlier work has suggested that delta, theta and gamma oscillations entrain to the speech rhythm. We used magnetoencephalography and a large sample of 102 participants to investigate oscillatory entrainment to speech, and observed robust entrainment of delta and theta activity, and weak group-level gamma entrainment. We show that the peak frequency and the hemispheric lateralisation of the entrainment are subject to considerable individual variability. The first finding may support the involvement of intrinsic oscillations in entrainment, and the second finding suggests that there is no systematic default right-hemispheric bias for processing acoustic signals on a slow time scale. Although low frequency entrainment to speech is a robust phenomenon, the characteristics of entrainment vary across individuals, and this variation is important for understanding the underlying neural mechanisms of entrainment, as well as its functional significance.
  • Lattenkamp, E. Z., Kaiser, S., Kaucic, R., Großmann, M., Koselj, K., & Goerlitz, H. R. (2018). Environmental acoustic cues guide the biosonar attention of a highly specialised echolocator. Journal of Experimental Biology, 221(8): jeb165696. doi:10.1242/jeb.165696.

    Abstract

    Sensory systems experience a trade-off between maximizing the
    detail and amount of sampled information. Thistrade-off is particularly
    pronounced in sensorysystemsthat are highlyspecialised fora single
    task and thus experience limitations in other tasks. We hypothesised
    that combining sensory input from multiple streams of information
    may resolve this trade-off and improve detection and sensing
    reliability. Specifically, we predicted that perceptive limitations
    experienced by animals reliant on specialised active echolocation
    can be compensated for by the phylogenetically older and less
    specialised process of passive hearing. We tested this hypothesis in
    greater horseshoe bats, which possess morphological and neural
    specialisations allowing them to identify fluttering prey in dense
    vegetation using echolocation only. At the same time, their
    echolocation system is both spatially and temporally severely
    limited. Here, we show that greater horseshoe bats employ passive
    hearing to initially detect and localise prey-generated and other
    environmental sounds, and then raise vocalisation level and
    concentrate the scanning movements of their sonar beam on the
    sound source for further investigation with echolocation. These
    specialised echolocators thus supplement echo-acoustic information
    with environmental acoustic cues, enlarging perceived space beyond
    their biosonar range. Contrary to our predictions, we did not find
    consistent preferences for prey-related acoustic stimuli, indicating the
    use of passive acoustic cues also for detection of non-prey objects.
    Our findings suggest that even specialised echolocators exploit a
    wide range of environmental information, and that phylogenetically
    older sensory systems can support the evolution of sensory
    specialisations by compensating for their limitations.
  • Lattenkamp, E. Z., Vernes, S. C., & Wiegrebe, L. (2018). Mammalian models for the study of vocal learning: A new paradigm in bats. In C. Cuskley, M. Flaherty, H. Little, L. McCrohon, A. Ravignani, & T. Verhoef (Eds.), Proceedings of the 12th International Conference on the Evolution of Language (EVOLANG XII) (pp. 235-237). Toruń, Poland: NCU Press. doi:10.12775/3991-1.056.
  • Lattenkamp, E. Z., & Vernes, S. C. (2018). Vocal learning: A language-relevant trait in need of a broad cross-species approach. Current Opinion in Behavioral Sciences, 21, 209-215. doi:10.1016/j.cobeha.2018.04.007.

    Abstract

    Although humans are unmatched in their capacity to produce
    speech and learn language, comparative approaches in diverse
    animalmodelsareabletoshedlightonthebiologicalunderpinnings
    of language-relevant traits. In the study of vocal learning, a trait
    crucial for spoken language, passerine birds have been the
    dominant models, driving invaluable progress in understanding the
    neurobiology and genetics of vocal learning despite being only
    distantly related to humans. To date, there is sparse evidence that
    our closest relatives, nonhuman primates have the capability to
    learn new vocalisations. However, a number of other mammals
    have shown the capacity for vocal learning, such as some
    cetaceans, pinnipeds, elephants, and bats, and we anticipate that
    with further study more species will gain membership to this
    (currently) select club. A broad, cross-species comparison of vocal
    learning, coupled with careful consideration of the components
    underlying this trait, is crucial to determine how human speech and
    spoken language is biologically encoded and how it evolved. We
    emphasise the need to draw on the pool of promising species that
    havethusfarbeenunderstudiedorneglected.Thisisbynomeansa
    call for fewer studies in songbirds, or an unfocused treasure-hunt,
    but rather an appeal for structured comparisons across a range of
    species, considering phylogenetic relationships, ecological and
    morphological constrains, developmental and social factors, and
    neurogenetic underpinnings. Herein, we promote a comparative
    approachhighlightingtheimportanceofstudyingvocallearningina
    broad range of model species, and describe a common framework
    for targeted cross-taxon studies to shed light on the biology and
    evolution of vocal learning.
  • Lattenkamp, E. Z., Vernes, S. C., & Wiegrebe, L. (2018). Volitional control of social vocalisations and vocal usage learning in bats. Journal of Experimental Biology, 221(14): jeb.180729. doi:10.1242/jeb.180729.

    Abstract

    Bats are gregarious, highly vocal animals that possess a broad repertoire of social vocalisations. For in-depth studies of their vocal behaviours, including vocal flexibility and vocal learning, it is necessary to gather repeatable evidence from controlled laboratory experiments on isolated individuals. However, such studies are rare for one simple reason: eliciting social calls in isolation and under operant control is challenging and has rarely been achieved. To overcome this limitation, we designed an automated setup that allows conditioning of social vocalisations in a new context, and tracks spectro-temporal changes in the recorded calls over time. Using this setup, we were able to reliably evoke social calls from temporarily isolated lesser spear-nosed bats (Phyllostomus discolor). When we adjusted the call criteria that could result in food reward, bats responded by adjusting temporal and spectral call parameters. This was achieved without the help of an auditory template or social context to direct the bats. Our results demonstrate vocal flexibility and vocal usage learning in bats. Our setup provides a new paradigm that allows the controlled study of the production and learning of social vocalisations in isolated bats, overcoming limitations that have, until now, prevented in-depth studies of these behaviours.

    Additional information

    JEB180729supp.pdf
  • Lauscher, A., Eckert, K., Galke, L., Scherp, A., Rizvi, S. T. R., Ahmed, S., Dengel, A., Zumstein, P., & Klein, A. (2018). Linked open citation database: Enabling libraries to contribute to an open and interconnected citation graph. In J. Chen, M. A. Gonçalves, J. M. Allen, E. A. Fox, M.-Y. Kan, & V. Petras (Eds.), JCDL '18: Proceedings of the 18th ACM/IEEE on Joint Conference on Digital Libraries (pp. 109-118). New York: ACM. doi:10.1145/3197026.3197050.

    Abstract

    Citations play a crucial role in the scientific discourse, in information retrieval, and in bibliometrics. Many initiatives are currently promoting the idea of having free and open citation data. Creation of citation data, however, is not part of the cataloging workflow in libraries nowadays.
    In this paper, we present our project Linked Open Citation Database, in which we design distributed processes and a system infrastructure based on linked data technology. The goal is to show that efficiently cataloging citations in libraries using a semi-automatic approach is possible. We specifically describe the current state of the workflow and its implementation. We show that we could significantly improve the automatic reference extraction that is crucial for the subsequent data curation. We further give insights on the curation and linking process and provide evaluation results that not only direct the further development of the project, but also allow us to discuss its overall feasibility.
  • Lee, J. J., Wedow, R., Okbay, A., Kong, E., Maghzian, O., Zacher, M., Nguyen-Viet, T. A., Bowers, P., Sidorenko, J., Linnér, R. K., Fontana, M. A., Kundu, T., Lee, C., Li, H., Li, R., Royer, R., Timshel, P. N., Walters, R. K., Willoughby, E. A., Yengo, L. and 57 moreLee, J. J., Wedow, R., Okbay, A., Kong, E., Maghzian, O., Zacher, M., Nguyen-Viet, T. A., Bowers, P., Sidorenko, J., Linnér, R. K., Fontana, M. A., Kundu, T., Lee, C., Li, H., Li, R., Royer, R., Timshel, P. N., Walters, R. K., Willoughby, E. A., Yengo, L., 23andMe Research Team, COGENT (Cognitive Genomics Consortium), Social Science Genetic Association Consortium, Alver, M., Bao, Y., Clark, D. W., Day, F. R., Furlotte, N. A., Joshi, P. K., Kemper, K. E., Kleinman, A., Langenberg, C., Mägi, R., Trampush, J. W., Verma, S. S., Wu, Y., Lam, M., Zhao, J. H., Zheng, Z., Boardman, J. D., Campbell, H., Freese, J., Harris, K. M., Hayward, C., Herd, P., Kumari, M., Lencz, T., Luan, J., Malhotra, A. K., Metspalu, A., Milani, L., Ong, K. K., Perry, J. R. B., Porteous, D. J., Ritchie, M. D., Smart, M. C., Smith, B. H., Tung, J. Y., Wareham, N. J., Wilson, J. F., Beauchamp, J. P., Conley, D. C., Esko, T., Lehrer, S. F., Magnusson, P. K. E., Oskarsson, S., Pers, T. H., Robinson, M. R., Thom, K., Watson, C., Chabris, C. F., Meyer, M. N., Laibson, D. I., Yang, J., Johannesson, M., Koellinger, P. D., Turley, P., Visscher, P. M., Benjamin, D. J., & Cesarini, D. (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50(8), 1112-1121. doi:10.1038/s41588-018-0147-3.

    Abstract

    Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.
  • Lefever, E., Hendrickx, I., Croijmans, I., Van den Bosch, A., & Majid, A. (2018). Discovering the language of wine reviews: A text mining account. In N. Calzolari, K. Choukri, C. Cieri, T. Declerck, S. Goggi, K. Hasida, H. Isahara, B. Maegaard, J. Mariani, H. Mazo, A. Moreno, J. Odijk, S. Piperidis, & T. Tokunaga (Eds.), Proceedings of the Eleventh International Conference on Language Resources and Evaluation (LREC 2018) (pp. 3297-3302). Paris: LREC.

    Abstract

    It is widely held that smells and flavors are impossible to put into words. In this paper we test this claim by seeking predictive patterns in wine reviews, which ostensibly aim to provide guides to perceptual content. Wine reviews have previously been critiqued as random and meaningless. We collected an English corpus of wine reviews with their structured metadata, and applied machine learning techniques to automatically predict the wine's color, grape variety, and country of origin. To train the three supervised classifiers, three different information sources were incorporated: lexical bag-of-words features, domain-specific terminology features, and semantic word embedding features. In addition, using regression analysis we investigated basic review properties, i.e., review length, average word length, and their relationship to the scalar values of price and review score. Our results show that wine experts do share a common vocabulary to describe wines and they use this in a consistent way, which makes it possible to automatically predict wine characteristics based on the review text alone. This means that odors and flavors may be more expressible in language than typically acknowledged.
  • Lehtonen, M., Cunillera, T., Rodríguez-Fornells, A., Hultén, A., Tuomainen, J., & Laine, M. (2007). Recognition of morphologically complex words in Finnish: Evidence from event-related potentials. Brain Research, 1148, 123-137. doi:10.1016/j.brainres.2007.02.026.

    Abstract

    The temporal dynamics of processing morphologically complex words was investigated by recording event-related brain potentials (ERPs) when native Finnish-speakers performed a visual lexical decision task. Behaviorally, there is evidence that recognition of inflected nouns elicits a processing cost (i.e., longer reaction times and higher error rates) in comparison to matched monomorphemic words. We aimed to reveal whether the processing cost stems from decomposition at the early visual word form level or from recomposition at the later semantic–syntactic level. The ERPs showed no early effects for morphology, but revealed an interaction with word frequency at a late N400-type component, as well as a late positive component that was larger for inflected words. These results suggest that the processing cost stems mainly from the semantic–syntactic level. We also studied the features of the morphological decomposition route by investigating the recognition of pseudowords carrying real morphemes. The results showed no differences between inflected vs. uninflected pseudowords with a false stem, but differences in relation to those with a real stem, suggesting that a recognizable stem is needed to initiate the decomposition route.
  • Lemhöfer, K., Huestegge, L., & Mulder, K. (2018). Another cup of TEE? The processing of second language near-cognates in first language reading. Language, Cognition and Neuroscience, 33(8), 968-991. doi:10.1080/23273798.2018.1433863.

    Abstract

    A still unresolved issue is in how far native language (L1) processing in bilinguals is influenced by the second language (L2). We investigated this in two word recognition experiments in L1, using homophonic near-cognates that are spelled in L2. In a German lexical decision task (Experiment 1), German-Dutch bilinguals had more difficulties to reject these Dutch-spelled near-cognates than other misspellings, while this was not the case for non-Dutch speaking Germans. In Experiment 2, the same materials were embedded in German sentences. Analyses of eye movements during reading showed that only non-Dutch speaking Germans, but not Dutch-speaking participants were slowed down by the Dutch cognate misspellings. Additionally, in both experiments, bilinguals with larger vocabulary sizes in Dutch tended to show larger near-cognate effects. Thus, Dutch word knowledge influenced word recognition in L1 German in both task contexts, suggesting that L1 word recognition in bilinguals is non-selective with respect to L2.
  • Lev-Ari, S. (2018). Social network size can influence linguistic malleability and the propagation of linguistic change. Cognition, 176, 31-39. doi:10.1016/j.cognition.2018.03.003.

    Abstract

    We learn language from our social environment, but the more sources we have, the less informative each source is, and therefore, the less weight we ascribe its input. According to this principle, people with larger social networks should give less weight to new incoming information, and should therefore be less susceptible to the influence of new speakers. This paper tests this prediction, and shows that speakers with smaller social networks indeed have more malleable linguistic representations. In particular, they are more likely to adjust their lexical boundary following exposure to a new speaker. Experiment 2 uses computational simulations to test whether this greater malleability could lead people with smaller social networks to be important for the propagation of linguistic change despite the fact that they interact with fewer people. The results indicate that when innovators were connected with people with smaller rather than larger social networks, the population exhibited greater and faster diffusion. Together these experiments show that the properties of people’s social networks can influence individuals’ learning and use as well as linguistic phenomena at the community level.
  • Lev-Ari, S. (2018). The influence of social network size on speech perception. Quarterly Journal of Experimental Psychology, 71(10), 2249-2260. doi:10.1177/1747021817739865.

    Abstract

    Infants and adults learn new phonological varieties better when exposed to multiple rather than a single speaker. This
    article tests whether having a larger social network similarly facilitates phonological performance. Experiment 1 shows
    that people with larger social networks are better at vowel perception in noise, indicating that the benefit of laboratory
    exposure to multiple speakers extends to real life experience and to adults tested in their native language. Furthermore,
    the experiment shows that this association is not due to differences in amount of input or to cognitive differences
    between people with different social network sizes. Follow-up computational simulations reveal that the benefit of
    larger social networks is mostly due to increased input variability. Additionally, the simulations show that the boost
    that larger social networks provide is independent of the amount of input received but is larger if the population is
    more heterogeneous. Finally, a comparison of “adult” and “child” simulations reconciles previous conflicting findings
    by suggesting that input variability along the relevant dimension might be less useful at the earliest stages of learning.
    Together, this article shows when and how the size of our social network influences our speech perception. It thus
    shows how aspects of our lifestyle can influence our linguistic performance.

    Additional information

    QJE-STD_17-073.R4-Table_A1.docx
  • Lev-Ari, S., Ho, E., & Keysar, B. (2018). The unforeseen consequences of interacting with non-native speakers. Topics in Cognitive Science, 10, 835-849. doi:10.1111/tops.12325.

    Abstract

    Sociolinguistic research shows that listeners' expectations of speakers influence their interpretation of the speech, yet this is often ignored in cognitive models of language comprehension. Here, we focus on the case of interactions between native and non-native speakers. Previous literature shows that listeners process the language of non-native speakers in less detail, because they expect them to have lower linguistic competence. We show that processing the language of non-native speakers increases lexical competition and access in general, not only of the non-native speaker's speech, and that this leads to poorer memory of one's own speech during the interaction. We further find that the degree to which people adjust their processing to non-native speakers is related to the degree to which they adjust their speech to them. We discuss implications for cognitive models of language processing and sociolinguistic research on attitudes.
  • Levelt, W. J. M. (1993). Die konnektionistische Mode. In J. Engelkamp, & T. Pechmann (Eds.), Mentale Repräsentation (pp. 51-62). Bern: Huber Verlag.
  • Levelt, W. J. M. (1993). Accessing words in speech production: Stages, processes and representations. In W. J. M. Levelt (Ed.), Lexical access in speech production (pp. 1-22). Cambridge, MA: Blackwell Publishers.

    Abstract

    Originally published in Cognition International Journal of Cognitive Science, Volume 42, Numbers 1-3, 1992 This paper introduces a special issue of Cognition 011 lexical access in speech production. Over the last quarter century, the psycholinguistic study of speaking, and in particular of accessing words in speech, received a major new impetus from the analysis of speech errors, dysfluencies and hesMions, from aphasiology, and from new paradigms in reaction time research. The emerging theoretical picture partitions the accessing process into two subprocesses, the selection of an appropriate lexical item (and "lemma") from the mental lexicon, and the phonological encoding of that item, that is, the computation of a phonetic program for the item in the context of utterance These two theoretical domains are successively introduced by outlining some core issues that have been or still have to be addressed. The final section discusses the controversial question whether phonological encoding can affect lexical selection. This partitioning is also followed in this special issue as a whole. There are, first, four papers on lexical selection, then three papers on phonological encoding, and finally one on the interaction between selection and phonological encoding.
  • Levelt, W. J. M. (2007). Levensbericht Detlev W. Ploog. In Levensberichten en herdenkingen 2007 (pp. 60-63). Amsterdam: Koninklijke Nederlandse Akademie van Wetenschappen.
  • Levelt, W. J. M. (1993). Lexical access in speech production. In E. Reuland, & W. Abraham (Eds.), Knowledge and language: Vol. 1. From Orwell's problem to Plato's problem (pp. 241-251). Dordrecht: Kluwer.
  • Levelt, W. J. M. (Ed.). (1993). Lexical access in speech production. Cambridge, Mass.: Blackwell.

    Abstract

    Formerly published in: Cognition : international journal of cognitive science, vol. 42, nos. 1-3, 1992
  • Levelt, W. J. M. (1993). Lexical selection, or how to bridge the major rift in language processing. In F. Beckmann, & G. Heyer (Eds.), Theorie und Praxis des Lexikons (pp. 164-172). Berlin: Walter de Gruyter.
  • Levelt, W. J. M. (2018). Is language natural to man? Some historical considerations. Current Opinion in Behavioral Sciences, 21, 127-131. doi:10.1016/j.cobeha.2018.04.003.

    Abstract

    Since the Enlightenment period, natural theories of speech and language evolution have florished in the language sciences. Four ever returning core issues are highlighted in this paper: Firstly, Is language natural to man or just an invention? Secondly, Is language a specific human ability (a ‘language instinct’) or does it arise from general cognitive capacities we share with other animals? Thirdly, Has the evolution of language been a gradual process or did it rather suddenly arise, due to some ‘evolutionary twist’? Lastly, Is the child's language acquisition an appropriate model for language evolution?
  • Levelt, W. J. M. (1993). The architecture of normal spoken language use. In G. Blanken, J. Dittman, H. Grimm, J. C. Marshall, & C.-W. Wallesch (Eds.), Linguistic disorders and pathologies: An international handbook (pp. 1-15). Berlin: Walter de Gruyter.
  • Levelt, W. J. M. (1993). Spreken als vaardigheid. In C. Blankenstijn, & A. Scheper (Eds.), Taalvaardigheid (pp. 1-16). Dordrecht: ICG Publications.
  • Levelt, W. J. M. (1993). Timing in speech production with special reference to word form encoding. Annals of the New York Academy of Sciences, 682, 283-295. doi:10.1111/j.1749-6632.1993.tb22976.x.
  • Levinson, S. C. (2007). Pragmática [Portugese translation of 'Pragmatics', 1983]. Sao Paulo: Martins Fontes Editora.

    Abstract

    The purpose of this book is to provide some indication of the scope of linguistic pragmatics. First the historical origin of the term pragmatics will be briefly summarized, in order to indicate some usages of the term that are divergent from the usage in this book. We will review some definitions of the field, which, while being less than fully statisfactory, will at least serve to indicate the rough scope of linguistic pragmatics. Thirdly, some reasons for the current interest in the field will be explained, while a final section illustrates some basic kinds of pragmatic phenomena. In passing, some analytical notions that are useful background will be introduced.
  • Levinson, S. C. (2007). Optimizing person reference - perspectives from usage on Rossel Island. In N. Enfield, & T. Stivers (Eds.), Person reference in interaction: Linguistic, cultural, and social perspectives (pp. 29-72). Cambridge: Cambridge University Press.

    Abstract

    This chapter explicates the requirement in person–reference for balancing demands for recognition, minimalization, explicitness and indirection. This is illustrated with reference to data from repair of failures of person–reference within a particular linguistic/cultural context, namely casual interaction among Rossel Islanders. Rossel Island (PNG) offers a ‘natural experiment’ for studying aspects of person reference, because of a number of special properties: 1. It is a closed universe of 4000 souls, sharing one kinship network, so in principle anyone could be recognizable from a reference. As a result no (complex) descriptions (cf. ‘ the author of Waverly’) are employed. 2. Names, however, are never uniquely referring, since they are drawn from a fixed pool. They are only used for about 25% of initial references, another 25% of initial references being done by kinship triangulation (‘that man’s father–in–law’). Nearly 50% of initial references are semantically underspecified or vague (e.g. ‘that girl’). 3. There are systematic motivations for oblique reference, e.g. kinship–based taboos and other constraints, which partly account for the underspecified references. The ‘natural experiment’ thus reveals some gneral lessons about how person–reference requires optimizing multiple conflicting constraints. Comparison with Sacks and Schegloff’s (1979) treatment of English person reference suggests a way to tease apart the universal and the culturally–particular.
  • Levinson, S. C., & Brown, P. (1993). Background to "Immanuel Kant among the Tenejapans". Anthropology Newsletter, 34(3), 22-23. doi:10.1111/an.1993.34.3.22.
  • Levinson, S. C., Cutfield, S., Dunn, M., Enfield, N. J., & Meira, S. (Eds.). (2018). Demonstratives in cross-linguistic perspective. Cambridge: Cambridge University Press.

    Abstract

    Demonstratives play a crucial role in the acquisition and use of language. Bringing together a team of leading scholars this detailed study, a first of its kind, explores meaning and use across fifteen typologically and geographically unrelated languages to find out what cross-linguistic comparisons and generalizations can be made, and how this might challenge current theory in linguistics, psychology, anthropology and philosophy. Using a shared experimental task, rounded out with studies of natural language use, specialists in each of the languages undertook extensive fieldwork for this comparative study of semantics and usage. An introduction summarizes the shared patterns and divergences in meaning and use that emerge.
  • Levinson, S. C., Senft, G., & Majid, A. (2007). Emotion categories in language and thought. In A. Majid (Ed.), Field Manual Volume 10 (pp. 46-52). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.492892.
  • Levinson, S. C. (2007). Cut and break verbs in Yélî Dnye, the Papuan language of Rossel Island. Cognitive Linguistics, 18(2), 207-218. doi:10.1515/COG.2007.009.

    Abstract

    The paper explores verbs of cutting and breaking (C&B, hereafter) in Yeli Dnye, the Papuan language of Rossel Island. The Yeli Dnye verbs covering the C&B domain do not divide it in the expected way, with verbs focusing on special instruments and manners of action on the one hand, and verbs focusing on the resultant state on the other. Instead, just three transitive verbs and their intransitive counterparts cover most of the domain, and they are all based on 'exotic' distinctions in mode of severance[--]coherent severance with the grain vs. against the grain, and incoherent severance (regardless of grain).
  • Levinson, S. C. (2007). Imi no suitei [Japanese translation of 'Presumptive meanings', 2000]. Tokyo: Kenkyusha.

    Abstract

    When we speak, we mean more than we say. In this book, the author explains some general processes that underlie presumptions in communication. This is the first extended discussion of preferred interpretation in language understanding, integrating much of the best research in linguistic pragmatics from the last two decades. Levinson outlines a theory of presumptive meanings, or preferred interpretations, governing the use of language, building on the idea of implicature developed by the philosopher H. P. Grice. Some of the indirect information carried by speech is presumed by default because it is carried by general principles, rather than inferred from specific assumptions about intention and context. Levinson examines this class of general pragmatic inferences in detail, showing how they apply to a wide range of linguistic constructions. This approach has radical consequences for how we think about language and communication.
  • Levinson, S. C. (1993). La Pragmatica [Italian translation of Pragmatics]. Bologna: Il Mulino.
  • Levinson, S. C., Majid, A., & Enfield, N. J. (2007). Language of perception: The view from language and culture. In A. Majid (Ed.), Field Manual Volume 10 (pp. 10-21). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.468738.
  • Levinson, S. C. (2018). Introduction: Demonstratives: Patterns in diversity. In S. C. Levinson, S. Cutfield, M. Dunn, N. J. Enfield, & S. Meira (Eds.), Demonstratives in cross-linguistic perspective (pp. 1-42). Cambridge: Cambridge University Press.
  • Levinson, S. C. (1993). Raumkonzeptionen mit absoluten Systemen. In Max Planck Gesellschaft Jahrbuch 1993 (pp. 297-299).
  • Levinson, S. C. (2018). Spatial cognition, empathy and language evolution. Studies in Pragmatics, 20, 16-21.

    Abstract

    The evolution of language and spatial cognition may have been deeply interconnected. The argument
    goes as follows: 1. Human native spatial abilities are poor, but we make up for it with linguistic
    and cultural prostheses; 2. The explanation for the loss of native spatial abilities may be
    that language has cannibalized the hippocampus, the mammalian mental ‘GPS’; 3. Consequently,
    language may have borrowed conceptual primitives from spatial cognition (in line with ‘localism’),
    these being differentially combined in different languages; 4. The hippocampus may have
    been colonized because: (a) space was prime subject matter for communication, (b) gesture uses
    space to represent space, and was likely precursor to language. In order to explain why the other
    great apes haven’t gone in the same direction, we need to invoke other factors, notably the ‘interaction
    engine’, the ensemble of interactional abilities that make cooperative communication possible
    and provide the matrix for the evolution and learning of language.
  • Levinson, S. C., & Majid, A. (2007). The language of sound. In A. Majid (Ed.), Field Manual Volume 10 (pp. 29-31). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.468735.
  • Levinson, S. C., & Majid, A. (2007). The language of vision II: Shape. In A. Majid (Ed.), Field Manual Volume 10 (pp. 26-28). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.468732.
  • Levinson, S. C. (2018). Yélî Dnye: Demonstratives in the language of Rossel Island, Papua New Guinea. In S. C. Levinson, S. Cutfield, M. Dunn, N. J. Enfield, & S. Meira (Eds.), Demonstratives in cross-linguistic perspective (pp. 318-342). Cambridge: Cambridge University Press.
  • Levshina, N. (2018). Probabilistic grammar and constructional predictability: Bayesian generalized additive models of help. GLOSSA-a journal of general linguistics, 3(1): 55. doi:10.5334/gjgl.294.

    Abstract

    The present study investigates the construction with help followed by the bare or to-infinitive in seven varieties of web-based English from Australia, Ghana, Great Britain, Hong Kong, India, Jamaica and the USA. In addition to various factors known from the literature, such as register, minimization of cognitive complexity and avoidance of identity (horror aequi), it studies the effect of predictability of the infinitive given help and the other way round on the language user’s choice between the constructional variants. These probabilistic constraints are tested in a series of Bayesian generalized additive mixed-effects regression models. The results demonstrate that the to-infinitive is particularly frequent in contexts with low predictability, or, in information-theoretic terms, with high information content. This tendency is interpreted as communicatively efficient behaviour, when more predictable units of discourse get less formal marking, and less predictable ones get more formal marking. However, the strength, shape and directionality of predictability effects exhibit variation across the countries, which demonstrates the importance of the cross-lectal perspective in research on communicative efficiency and other universal functional principles.
  • Lewis, A. G., Schriefers, H., Bastiaansen, M., & Schoffelen, J.-M. (2018). Assessing the utility of frequency tagging for tracking memory-based reactivation of word representations. Scientific Reports, 8: 7897. doi:10.1038/s41598-018-26091-3.

    Abstract

    Reinstatement of memory-related neural activity measured with high temporal precision potentially provides a useful index for real-time monitoring of the timing of activation of memory content during cognitive processing. The utility of such an index extends to any situation where one is interested in the (relative) timing of activation of different sources of information in memory, a paradigm case of which is tracking lexical activation during language processing. Essential for this approach is that memory reinstatement effects are robust, so that their absence (in the average) definitively indicates that no lexical activation is present. We used electroencephalography to test the robustness of a reported subsequent memory finding involving reinstatement of frequency-specific entrained oscillatory brain activity during subsequent recognition. Participants learned lists of words presented on a background flickering at either 6 or 15 Hz to entrain a steady-state brain response. Target words subsequently presented on a non-flickering background that were correctly identified as previously seen exhibited reinstatement effects at both entrainment frequencies. Reliability of these statistical inferences was however critically dependent on the approach used for multiple comparisons correction. We conclude that effects are not robust enough to be used as a reliable index of lexical activation during language processing.

    Additional information

    Lewis_etal_2018sup.docx
  • Liang, S., Vega, R., Kong, X., Deng, W., Wang, Q., Ma, X., Li, M., Hu, X., Greenshaw, A. J., Greiner, R., & Li, T. (2018). Neurocognitive Graphs of First-Episode Schizophrenia and Major Depression Based on Cognitive Features. Neuroscience Bulletin, 34(2), 312-320. doi:10.1007/s12264-017-0190-6.

    Abstract

    Neurocognitive deficits are frequently observed in patients with schizophrenia and major depressive disorder (MDD). The relations between cognitive features may be represented by neurocognitive graphs based on cognitive features, modeled as Gaussian Markov random fields. However, it is unclear whether it is possible to differentiate between phenotypic patterns associated with the differential diagnosis of schizophrenia and depression using this neurocognitive graph approach. In this study, we enrolled 215 first-episode patients with schizophrenia (FES), 125 with MDD, and 237 demographically-matched healthy controls (HCs). The cognitive performance of all participants was evaluated using a battery of neurocognitive tests. The graphical LASSO model was trained with a one-vs-one scenario to learn the conditional independent structure of neurocognitive features of each group. Participants in the holdout dataset were classified into different groups with the highest likelihood. A partial correlation matrix was transformed from the graphical model to further explore the neurocognitive graph for each group. The classification approach identified the diagnostic class for individuals with an average accuracy of 73.41% for FES vs HC, 67.07% for MDD vs HC, and 59.48% for FES vs MDD. Both of the neurocognitive graphs for FES and MDD had more connections and higher node centrality than those for HC. The neurocognitive graph for FES was less sparse and had more connections than that for MDD. Thus, neurocognitive graphs based on cognitive features are promising for describing endophenotypes that may discriminate schizophrenia from depression.

    Additional information

    Liang_etal_2017sup.pdf
  • Ligthart, S., Vaez, A., Võsa, U., Stathopoulou, M. G., De Vries, P. S., Prins, B. P., Van der Most, P. J., Tanaka, T., Naderi, E., Rose, L. M., Wu, Y., Karlsson, R., Barbalic, M., Lin, H., Pool, R., Zhu, G., Macé, A., Sidore, C., Trompet, S., Mangino, M. and 267 moreLigthart, S., Vaez, A., Võsa, U., Stathopoulou, M. G., De Vries, P. S., Prins, B. P., Van der Most, P. J., Tanaka, T., Naderi, E., Rose, L. M., Wu, Y., Karlsson, R., Barbalic, M., Lin, H., Pool, R., Zhu, G., Macé, A., Sidore, C., Trompet, S., Mangino, M., Sabater-Lleal, M., Kemp, J. P., Abbasi, A., Kacprowski, T., Verweij, N., Smith, A. V., Huang, T., Marzi, C., Feitosa, M. F., Lohman, K. K., Kleber, M. E., Milaneschi, Y., Mueller, C., Huq, M., Vlachopoulou, E., Lyytikäinen, L.-P., Oldmeadow, C., Deelen, J., Perola, M., Zhao, J. H., Feenstra, B., LifeLines Cohort Study, Amini, M., CHARGE Inflammation Working Group, Lahti, J., Schraut, K. E., Fornage, M., Suktitipat, B., Chen, W.-M., Li, X., Nutile, T., Malerba, G., Luan, J., Bak, T., Schork, N., Del Greco M., F., Thiering, E., Mahajan, A., Marioni, R. E., Mihailov, E., Eriksson, J., Ozel, A. B., Zhang, W., Nethander, M., Cheng, Y.-C., Aslibekyan, S., Ang, W., Gandin, I., Yengo, L., Portas, L., Kooperberg, C., Hofer, E., Rajan, K. B., Schurmann, C., Den Hollander, W., Ahluwalia, T. S., Zhao, J., Draisma, H. H. M., Ford, I., Timpson, N., Teumer, A., Huang, H., Wahl, S., Liu, Y., Huang, J., Uh, H.-W., Geller, F., Joshi, P. K., Yanek, L. R., Trabetti, E., Lehne, B., Vozzi, D., Verbanck, M., Biino, G., Saba, Y., Meulenbelt, I., O’Connell, J. R., Laakso, M., Giulianini, F., Magnusson, P. K. E., Ballantyne, C. M., Hottenga, J. J., Montgomery, G. W., Rivadineira, F., Rueedi, R., Steri, M., Herzig, K.-H., Stott, D. J., Menni, C., Franberg, M., St Pourcain, B., Felix, S. B., Pers, T. H., Bakker, S. J. L., Kraft, P., Peters, A., Vaidya, D., Delgado, G., Smit, J. H., Großmann, V., Sinisalo, J., Seppälä, I., Williams, S. R., Holliday, E. G., Moed, M., Langenberg, C., Räikkönen, K., Ding, J., Campbell, H., Sale, M. M., Chen, Y.-D.-I., James, A. L., Ruggiero, D., Soranzo, N., Hartman, C. A., Smith, E. N., Berenson, G. S., Fuchsberger, C., Hernandez, D., Tiesler, C. M. T., Giedraitis, V., Liewald, D., Fischer, K., Mellström, D., Larsson, A., Wang, Y., Scott, W. R., Lorentzon, M., Beilby, J., Ryan, K. A., Pennell, C. E., Vuckovic, D., Balkau, B., Concas, M. P., Schmidt, R., Mendes de Leon, C. F., Bottinger, E. P., Kloppenburg, M., Paternoster, L., Boehnke, M., Musk, A. W., Willemsen, G., Evans, D. M., Madden, P. A. F., Kähönen, M., Kutalik, Z., Zoledziewska, M., Karhunen, V., Kritchevsky, S. B., Sattar, N., Lachance, G., Clarke, R., Harris, T. B., Raitakari, O. T., Attia, J. R., Van Heemst, D., Kajantie, E., Sorice, R., Gambaro, G., Scott, R. A., Hicks, A. A., Ferrucci, L., Standl, M., Lindgren, C. M., Starr, J. M., Karlsson, M., Lind, L., Li, J. Z., Chambers, J. C., Mori, T. A., De Geus, E. J. C. N., Heath, A. C., Martin, N. G., Auvinen, J., Buckley, B. M., De Craen, A. J. M., Waldenberger, M., Strauch, K., Meitinger, T., Scott, R. J., McEvoy, M., Beekman, M., Bombieri, C., Ridker, P. M., Mohlke, K. L., Pedersen, N. L., Morrison, A. C., Boomsma, D. I., Whitfield, J. B., Strachan, D. P., Hofman, A., Vollenweider, P., Cucca, F., Jarvelin, M.-R., Jukema, J. W., Spector, T. D., Hamsten, A., Zeller, T., Uitterlinden, A. G., Nauck, M., Gudnason, V., Qi, L., Grallert, H., Borecki, I. B., Rotter, J. I., März, W., Wild, P. S., Lokki, M.-L., Boyle, M., Salomaa, V., Melbye, M., Eriksson, J. G., Wilson, J. F., Penninx, B. W. J. H., Becker, D. M., Worrall, B. B., Gibson, G., Krauss, R. M., Ciullo, M., Zaza, G., Wareham, N. J., Oldehinkel, A. J., Palmer, L. J., Murray, S. S., Pramstaller, P. P., Bandinelli, S., Heinrich, J., Ingelsson, E., Deary, I. J., Ma¨gi, R., Vandenput, L., Van der Harst, P., Desch, K. C., Kooner, J. S., Ohlsson, C., Hayward, C., Lehtima¨ki, T., Shuldiner, A. R., Arnett, D. K., Beilin, L. J., Robino, A., Froguel, P., Pirastu, M., Jess, T., Koenig, W., Loos, R. J. F., Evans, D. A., Schmidt, H., Smith, G. D., Slagboom, P. E., Eiriksdottir, G., Morris, A. P., Psaty, B. M., Tracy, R. P., Nolte, I. M., Boerwinkle, E., Visvikis-Siest, S., Reiner, A. P., Gross, M., Bis, J. C., Franke, L., Franco, O. H., Benjamin, E. J., Chasman, D. I., Dupuis, J., Snieder, H., Dehghan, A., & Alizadeh, B. Z. (2018). Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. The American Journal of Human Genetics, 103(5), 691-706. doi:10.1016/j.ajhg.2018.09.009.

    Abstract

    C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we performed in silico functional analyses and Mendelian randomization analyses with several clinical outcomes. The GWAS meta-analyses of CRP revealed 58 distinct genetic loci (p < 5 × 10−8). After adjustment for body mass index in the regression analysis, the associations at all except three loci remained. The lead variants at the distinct loci explained up to 7.0% of the variance in circulating amounts of CRP. We identified 66 gene sets that were organized in two substantially correlated clusters, one mainly composed of immune pathways and the other characterized by metabolic pathways in the liver. Mendelian randomization analyses revealed a causal protective effect of CRP on schizophrenia and a risk-increasing effect on bipolar disorder. Our findings provide further insights into the biology of inflammation and could lead to interventions for treating inflammation and its clinical consequences.
  • Lindström, E., Terrill, A., Reesink, G., & Dunn, M. (2007). The languages of Island Melanesia. In J. S. Friedlaender (Ed.), Genes, language, and culture history in the Southwest Pacific (pp. 118-140). Oxford: Oxford University Press.

    Abstract

    This chapter provides an overview of the Papuan and the Oceanic languages (a branch of Austronesian) in Northern Island Melanesia, as well as phenomena arising through contact between these groups. It shows how linguistics can contribute to the understanding of the history of languages and speakers, and what the findings of those methods have been. The location of the homeland of speakers of Proto-Oceanic is indicated (in northeast New Britain); many facets of the lives of those speakers are shown; and the patterns of their subsequent spread across Island Melanesia and beyond into Remote Oceania are indicated, followed by a second wave overlaying the first into New Guinea and as far as halfway through the Solomon Islands. Regarding the Papuan languages of this region, at least some are older than the 6,000-10,000 ceiling of the Comparative Method, and their relations are explored with the aid of a database of 125 non-lexical structural features. The results reflect archipelago-based clustering with the Central Solomons Papuan languages forming a clade either with the Bismarcks or with Bougainville languages. Papuan languages in Bougainville are less influenced by Oceanic languages than those in the Bismarcks and the Solomons. The chapter considers a variety of scenarios to account for their findings, concluding that the results are compatible with multiple pre-Oceanic waves of arrivals into the area after initial settlement.
  • Liszkowski, U. (2007). Human twelve-month-olds point cooperatively to share interest with and helpfully provide information for a communicative partner. In K. Liebal, C. Müller, & S. Pika (Eds.), Gestural communication in nonhuman and human primates (pp. 124-140). Amsterdam: Benjamins.

    Abstract

    This paper investigates infant pointing at 12 months. Three recent experimental studies from our lab are reported and contrasted with existing accounts on infant communicative and social-cognitive abilities. The new results show that infant pointing at 12 months already is a communicative act which involves the intentional transmission of information to share interest with, or provide information for other persons. It is argued that infant pointing is an inherently social and cooperative act which is used to share psychological relations between interlocutors and environment, repairs misunderstandings in proto-conversational turn-taking, and helps others by providing information. Infant pointing builds on an understanding of others as persons with attentional states and attitudes. Findings do not support lean accounts on early infant pointing which posit that it is initially non-communicative, does not serve the function of indicating, or is purely self-centered. It is suggested to investigate the emergence of reference and the motivation to jointly engage with others also before pointing has emerged.
  • Liszkowski, U., & Brown, P. (2007). Infant pointing (9-15 months) in different cultures. In A. Majid (Ed.), Field Manual Volume 10 (pp. 82-88). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.492895.

    Abstract

    There are two tasks for conducting systematic observation of child-caregiver joint attention interactions. Task 1 – a “decorated room” designed to elicit infant and caregiver pointing. Task 2 – videotaped interviews about infant pointing behaviour. The goal of this task is to document the ontogenetic emergence of referential communication in caregiver infant interaction in different cultures, during the critical age of 8-15 months when children come to understand and share others’ intentions. This is of interest to all students of interaction and human communication; it does not require specialist knowledge of children.
  • Liszkowski, U., Carpenter, M., & Tomasello, M. (2007). Reference and attitude in infant pointing. Journal of Child Language, 34(1), 1-20. doi:10.1017/S0305000906007689.

    Abstract

    We investigated two main components of infant declarative pointing, reference and attitude, in two experiments with a total of 106 preverbal infants at 1;0. When an experimenter (E) responded to the declarative pointing of these infants by attending to an incorrect referent (with positive attitude), infants repeated pointing within trials to redirect E’s attention, showing an understanding of E’s reference and active message repair. In contrast, when E identified infants’ referent correctly but displayed a disinterested attitude, infants did not repeat pointing within trials and pointed overall in fewer trials, showing an understanding of E’s unenthusiastic attitude about the referent. When E attended to infants’ intended referent AND shared interest in it, infants were most satisfied, showing no message repair within trials and pointing overall in more trials. These results suggest that by twelve months of age infant declarative pointing is a full communicative act aimed at sharing with others both attention to a referent and a specific attitude about that referent.
  • Liszkowski, U., Carpenter, M., & Tomasello, M. (2007). Pointing out new news, old news, and absent referents at 12 months of age. Developmental Science, 10(2), F1-F7. doi:0.1111/j.1467-7687.2006.00552.x.

    Abstract

    There is currently controversy over the nature of 1-year-olds' social-cognitive understanding and motives. In this study we investigated whether 12-month-old infants point for others with an understanding of their knowledge states and with a prosocial motive for sharing experiences with them. Declarative pointing was elicited in four conditions created by crossing two factors: an adult partner (1) was already attending to the target event or not, and (2) emoted positively or neutrally. Pointing was also coded after the event had ceased. The findings suggest that 12-month-olds point to inform others of events they do not know about, that they point to share an attitude about mutually attended events others already know about, and that they can point (already prelinguistically) to absent referents. These findings provide strong support for a mentalistic and prosocial interpretation of infants' prelinguistic communication
  • Liu, X., Gao, Y., Di, Q., Hu, J., Lu, C., Nan, Y., Booth, J. R., & Liu, L. (2018). Differences between child and adult large-scale functional brain networks for reading tasks. Human Brain Mapping, 39(2), 662-679. doi:10.1002/hbm.23871.

    Abstract

    Reading is an important high‐level cognitive function of the human brain, requiring interaction among multiple brain regions. Revealing differences between children's large‐scale functional brain networks for reading tasks and those of adults helps us to understand how the functional network changes over reading development. Here we used functional magnetic resonance imaging data of 17 adults (19–28 years old) and 16 children (11–13 years old), and graph theoretical analyses to investigate age‐related changes in large‐scale functional networks during rhyming and meaning judgment tasks on pairs of visually presented Chinese characters. We found that: (1) adults had stronger inter‐regional connectivity and nodal degree in occipital regions, while children had stronger inter‐regional connectivity in temporal regions, suggesting that adults rely more on visual orthographic processing whereas children rely more on auditory phonological processing during reading. (2) Only adults showed between‐task differences in inter‐regional connectivity and nodal degree, whereas children showed no task differences, suggesting the topological organization of adults’ reading network is more specialized. (3) Children showed greater inter‐regional connectivity and nodal degree than adults in multiple subcortical regions; the hubs in children were more distributed in subcortical regions while the hubs in adults were more distributed in cortical regions. These findings suggest that reading development is manifested by a shift from reliance on subcortical to cortical regions. Taken together, our study suggests that Chinese reading development is supported by developmental changes in brain connectivity properties, and some of these changes may be domain‐general while others may be specific to the reading domain.
  • Xu, S., Liu, P., Chen, Y., Chen, Y., Zhang, W., Zhao, H., Cao, Y., Wang, F., Jiang, N., Lin, S., Li, B., Zhang, Z., Wei, Z., Fan, Y., Jin, Y., He, L., Zhou, R., Dekker, J. D., Tucker, H. O., Fisher, S. E. and 4 moreXu, S., Liu, P., Chen, Y., Chen, Y., Zhang, W., Zhao, H., Cao, Y., Wang, F., Jiang, N., Lin, S., Li, B., Zhang, Z., Wei, Z., Fan, Y., Jin, Y., He, L., Zhou, R., Dekker, J. D., Tucker, H. O., Fisher, S. E., Yao, Z., Liu, Q., Xia, X., & Guo, X. (2018). Foxp2 regulates anatomical features that may be relevant for vocal behaviors and bipedal locomotion. Proceedings of the National Academy of Sciences of the United States of America, 115(35), 8799-8804. doi:10.1073/pnas.1721820115.

    Abstract

    Fundamental human traits, such as language and bipedalism, are associated with a range of anatomical adaptations in craniofacial shaping and skeletal remodeling. However, it is unclear how such morphological features arose during hominin evolution. FOXP2 is a brain-expressed transcription factor implicated in a rare disorder involving speech apraxia and language impairments. Analysis of its evolutionary history suggests that this gene may have contributed to the emergence of proficient spoken language. In the present study, through analyses of skeleton-specific knockout mice, we identified roles of Foxp2 in skull shaping and bone remodeling. Selective ablation of Foxp2 in cartilage disrupted pup vocalizations in a similar way to that of global Foxp2 mutants, which may be due to pleiotropic effects on craniofacial morphogenesis. Our findings also indicate that Foxp2 helps to regulate strength and length of hind limbs and maintenance of joint cartilage and intervertebral discs, which are all anatomical features that are susceptible to adaptations for bipedal locomotion. In light of the known roles of Foxp2 in brain circuits that are important for motor skills and spoken language, we suggest that this gene may have been well placed to contribute to coevolution of neural and anatomical adaptations related to speech and bipedal locomotion.

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  • Long, M., Horton, W. S., Rohde, H., & Sorace, A. (2018). Individual differences in switching and inhibition predict perspective-taking across the lifespan. Cognition, 170, 25-30. doi:10.1016/j.cognition.2017.09.004.

    Abstract

    Studies exploring the influence of executive functions (EF) on perspective-taking have focused on inhibition and working memory in young adults or clinical populations. Less consideration has been given to more complex capacities that also involve switching attention between perspectives, or to changes in EF and concomitant effects on perspective-taking across the lifespan. To address this, we assessed whether individual differences in inhibition and attentional switching in healthy adults (ages 17–84) predict performance on a task in which speakers identified targets for a listener with size-contrasting competitors in common or privileged ground. Modification differences across conditions decreased with age. Further, perspective taking interacted with EF measures: youngest adults’ sensitivity to perspective was best captured by their inhibitory performance; oldest adults’ sensitivity was best captured by switching performance. Perspective-taking likely involves multiple aspects of EF, as revealed by considering a wider range of EF tasks and individual capacities across the lifespan.

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