Publications

Abstract

Successful navigation is facilitated by the presence of landmarks. Previous functional magnetic resonance imaging (fMRI) evidence indicated that the human parahippocampal gyrus automatically distinguishes between landmarks placed at navigationally relevant (decision points) and irrelevant locations (nondecision points). This storage of navigational relevance can provide a neural mechanism underlying successful navigation. However, an efficient wayfinding mechanism requires that important spatial information is learned quickly and maintained over time. The present study investigates whether the representation of navigational relevance is modulated by time and practice. Participants learned 2 film sequences through virtual mazes containing objects at decision and at nondecision points. One maze was shown one time, and the other maze was shown 3 times. Twenty-four hours after study, event-related fMRI data were acquired during recognition of the objects. The results showed that activity in the parahippocampal gyrus was increased for objects previously placed at decision points as compared with objects placed at nondecision points. The decision point effect was not modulated by the number of exposures to the mazes and independent of explicit memory functions. These findings suggest a persistent representation of navigationally relevant information, which is stable after only one exposure to an environment. These rapidly induced and long-lasting changes in object representation provide a basis for successful wayfinding.

Abstract

The human brain distinguishes between landmarks placed at navigationally relevant and irrelevant locations. However, to provide a successful wayfinding mechanism not only landmarks but also the routes between them need to be stored. We examined the neural representation of a memory for route direction and a memory for relevant landmarks. Healthy human adults viewed objects along a route through a virtual maze. Event-related functional magnetic resonance imaging (fMRI) data were acquired during a subsequent subliminal priming recognition task. Prime-objects either preceded or succeeded a target-object on a preciously learned route. Our results provide evidence that the parahippocampal gyri distinguish between relevant and irrelevant landmarks whereas the inferior parietal gyrus, the anterior cingulate gyrus as well as the right caudate nucleus are involved in the coding of route direction. These data show that separated memory systems store different spatial information. A memory for navigationally relevant object information and a memory for route direction exist.

Abstract

Listeners use lexical knowledge to adjust their prelexical representations of speech sounds in response to the idiosyncratic pronunciations of particular speakers. We used an exposure-test paradigm to investigate whether this type of perceptual learning transfers across syllabic positions. No significant learning effect was found in Experiment 1, where exposure sounds were onsets and test sounds were codas. Experiments 2-4 showed that there was no learning even when both exposure and test sounds were onsets. But a trend was found when exposure sounds were codas and test sounds were onsets (Experiment 5). This trend was smaller than the robust effect previously found for the coda-to-coda case. These findings suggest that knowledge about idiosyncratic pronunciations may be position specific: Knowledge about how a speaker produces sounds in one position, if it can be acquired at all, influences perception of sounds in that position more strongly than of sounds in another position.

Abstract

Words repeated in the same voice are better recognized than when they are repeated in a different voice. Such findings have been taken as evidence for the storage of talker-specific lexical episodes. But results on perceptual learning suggest that talker-specific adjustments concern sublexical representations. This study thus investigates whether voice-specific repetition effects in auditory lexical decision are lexical or sublexical. The same critical set of items in Block 2 were, depending on materials in Block 1, either same-voice or different-voice word repetitions, new words comprising re-orderings of phonemes used in the same voice in Block 1, or new words with previously unused phonemes. Results show a benefit for words repeated by the same talker, and a smaller benefit for words consisting of phonemes repeated by the same talker. Talker-specific information thus appears to influence word recognition at multiple representational levels.

Abstract

Listeners use suprasegmental auditory lexical stress information to resolve the competition words engage in during spoken-word recognition. The present study investigated whether (a) visual speech provides lexical stress information, and, more importantly, (b) whether this visual lexical stress information is used to resolve lexical competition. Dutch word pairs that differ in the lexical stress realization of their first two syllables, but not segmentally (e.g., 'OCtopus' and 'okTOber'; capitals marking primary stress) served as auditory-only, visual-only, and audiovisual speech primes. These primes either matched (e.g., 'OCto-'), mismatched (e.g., 'okTO-'), or were unrelated to (e.g., 'maCHI-') a subsequent printed target (octopus), which participants had to make a lexical decision to. To the degree that visual speech contains lexical stress information, lexical decisions to printed targets should be modulated through the addition of visual speech. Results show, however, no evidence for a role of visual lexical stress information in audiovisual spoken-word recognition.

Abstract

This study investigates the time-course of information processing in both visual as well as in the auditory speech as used for word identification in face-to-face communication. It extends the limited previous research on this topic and provides a valuable database for future research in audiovisual speech perception. An evaluation of models of speech perception by ear and eye in their ability to account for the audiovisual gating data shows a superior role of the fuzzy logical model of perception (FLMP) [1] over additive models of perception. A new dynamic version of the FLMP seems to be a promising model to account for the complex interplay of perceptual and cognitive information in audiovisual spoken word recognition.

Abstract

In face-to-face communication, information from the face as well as from the voice contributes to the identification of spoken words. This dissertation investigates the time-course of the evaluation and integration of visual and auditory speech in audiovisual word identification. A large-scale audiovisual gating study extends previous research on this topic by (1) using a set of words that includes all possible initial consonants in English in three vowel contexts, (2) tracking the information processing for individual words not only across modalities, but also over time, and (3) testing quantitative models of the time-course of multimodal word recognition. There was an advantage in accuracy for audiovisual speech over auditory-only and visual-only speech. Auditory performance was, however, close to ceiling while performance on visual-only trials was near the floor of the scale, but well above chance. Visual information was used at all gates to identify the presented words. Information theoretic feature analyses of the confusion matrices revealed that the auditory signal is highly informative about voicing, manner, frication, duration, and place of articulation. Visual speech is mostly informative about place of articulation, but also about frication and duration. The auditory signal provides more information about the place of articulation for back consonants, whereas the visual signal provides more information for the labial consonants. The data were sufficient to discriminate between models of audiovisual word recognition. The Fuzzy Logical Model of Perception (FLMP; Massaro, 1998) gave a better account of the confusion matrix data than additive models of perception. A dynamic version of the FLMP was expanded to account for the evaluation and integration of information over time. This dynamic FLMP provided a better description of the data than dynamic additive competitor models. The present study builds a good foundation to investigate the role of the complex interplay between stimulus information and the structure of the lexicon. It provides an important step in building a formal representation of a lexical dynamic FLMP that can account not only for the time-course of speech information and its perceptual processing, but also for lexical influences.

Abstract

We investigate differences of cerebral activation in 12 right-handed and left-handed participants, respectively, using a sentence-processing task. Functional MRI shows activation of left-frontal and inferior-parietal speech areas (BA 44, BA9, BA 40) in both groups, but a stronger bilateral activation in left-handers. Direct group comparison reveals a stronger activation in right-frontal cortex (BA 47, BA 6) and left cerebellum in left-handers. Laterality indices for the inferior-frontal cortex are less asymmetric in left-handers and are not related to the degree of handedness. Thus, our results show that sentence-processing induced enhanced activation involving a bilateral network in left-handed participants.

Abstract

Mutations of the epidermal growth factor receptor (EGFR) gene are found at a relatively high frequency in glioma, with the most common being the de2-7 EGFR (or EGFRvIII). This mutation arises from an in-frame deletion of exons 2–7, which removes 267 amino acids from the extracellular domain of the receptor. Despite being unable to bind ligand, the de2-7 EGFR is constitutively active at a low level. Transfection of human glioma cells with the de2-7 EGFR has little effect in vitro, but when grown as tumor xenografts this mutated receptor imparts a dramatic growth advantage. We have now mapped the phosphorylation pattern of de2-7 EGFR, both in vivo and in vitro, using a panel of antibodies unique to the different phosphorylated tyrosine residues. Phosphorylation of de2-7 EGFR was detected constitutively at all tyrosine sites surveyed both in vitro and in vivo, including tyrosine 845, a known target in the wild-type EGFR for src kinase. There was a substantial upregulation of phosphorylation at every tyrosine residue of the de2-7 EGFR when cells were grown in vivo compared to the receptor isolated from cells cultured in vitro. Upregulation of phosphorylation could be mimicked in vitro by the addition of specifi c components of the ECM such as collagen via an integrin-dependent mechanism. Since this increase in in vivo phosphorylation enhances de2-7 EGFR signaling, this observation explains why the growth enhancement mediated by de2-7 EGFR is largely restricted to the in vivo environment. In a second set of experiments we analyzed the interaction between EGFRvIII and ErbB2. Co-expression of these proteins in NR6 cells, a mouse fi broblast line devoid of ErbB family members, dramatically enhanced in vivo tumorigenicity of these cells compared to cells expressing either protein alone. Detailed analysis of these xenografts demonstrated that EGFRvIII could heterodimerize and transphosphorylate the ErbB2. Since both EGFRvIII and ErbB2 are commonly expressed at gliomas, this data suggests that the co-expression of these two proteins may enhance glioma tumorigenicity.

Abstract

Purpose: Factors affecting the efficacy of therapeutic monoclonal antibodies (mAb) directed to the epidermal growth factor receptor (EGFR) remain relatively unknown, especially in glioma. Experimental Design: We examined the efficacy of two EGFR-specific mAbs (mAbs 806 and 528) against U87MG-derived glioma xenografts expressing EGFR variants. Using this approach allowed us to change the form of the EGFR while keeping the genetic background constant. These variants included the de2-7 EGFR (or EGFRvIII), a constitutively active mutation of the EGFR expressed in glioma. Results: The efficacy of the mAbs correlated with EGFR number; however, the most important factor was receptor activation. Whereas U87MG xenografts expressing the de2-7 EGFR responded to therapy, those exhibiting a dead kinase de2-7 EGFR were refractory. A modified de2-7 EGFR that was kinase active but autophosphorylation deficient also responded, suggesting that these mAbs function in de2-7 EGFR–expressing xenografts by blocking transphosphorylation. Because de2-7 EGFR–expressing U87MG xenografts coexpress the wild-type EGFR, efficacy of the mAbs was also tested against NR6 xenografts that expressed the de2-7 EGFR in isolation. Whereas mAb 806 displayed antitumor activity against NR6 xenografts, mAb 528 therapy was ineffective, suggesting that mAb 528 mediates its antitumor activity by disrupting interactions between the de2-7 and wild-type EGFR. Finally, genetic disruption of Src in U87MG xenografts expressing the de2-7 EGFR dramatically enhanced mAb 806 efficacy. Conclusions: The effective use of EGFR-specific antibodies in glioma will depend on identifying tumors with activated EGFR. The combination of EGFR and Src inhibitors may be an effective strategy for the treatment of glioma.

Abstract

Retaining detailed representations of unstressed syllables is a logical prerequisite for infants' use of probabilistic phonotactics to segment iambic words from fluent speech. The head-turn preference study was used to investigate the nature of English- learners' representations of iambic word onsets. Fifty-four 10.5-month-olds were familiarized to passages containing the nonsense iambic word forms ginome and tupong. Following familiarization, infants were either tested on familiar (ginome and tupong) or near-familiar (pinome and bupong) versus unfamiliar (kidar and mafoos) words. Infants in the familiar test group (familiar vs. unfamiliar) oriented significantly longer to familiar than unfamiliar test items, whereas infants in the near-familiar test group (near-familiar vs. unfamiliar) oriented equally long to near-familiar and unfamiliar test items. Our results provide evidence that infants retain fairly detailed representations of unstressed syllables and therefore support the hypothesis that infants use phonotactic cues to find words in fluent speech.

Abstract

One critical aspect of language acquisition is the development of a lexicon that associates sounds and meanings; but developing a lexicon first requires that the infant segment utterances into individual words. How might the infant begin this process? The present study was designed to examine the potential role that sensitivity to predominant stress patterns of words might play in lexical development. In English, by far the majority of words have stressed (strong) initial syllables. Experiment 1 of our study demonstrated that by 9 months of age American infants listen significantly longer to words with strong/weak stress patterns than to words with weak/strong stress patterns. However, Experiment 2 showed that no significant preferences for the predominant stress pattern appear with 6-month-old infants, which suggests that the preference develops as a result of increasing familiarity with the prosodic features of the native language. In a third experiment, 9-month-olds showed a preference for strong/weak patterns even when the speech input was low-pass filtered, which suggests that their preference is specifically for the prosodic structure of the words. Together the results suggest that attention to predominant stress patterns in the native language may form an important part of the infant's process of developing a lexicon.

Abstract

Day-to-day interpretations of “space” are enmeshed in specific cultural and linguistic practices. For example, many cultures have an association between vertical height and social standing; more powerful people may be placed literally higher than others at social gatherings, and be spoken of as having higher status. This questionnaire is a guide for exploring relationships between space, language, and social structure. The goal is to better understand how space is organised in the focus community, and to investigate the extent to which space is used as a model for reproducing social forms.

Abstract

When you compare the behavior of two different age groups which are trying to master the same sensori-motor or cognitive skill, you are likely to discover varying learning routes: different stages, different intervals between stages, or even different orderings of stages. Such heterogeneous learning trajectories may be caused by at least six different types of factors: (1) Initial state: the kinds and levels of skills the learners have available at the onset of the learning episode. (2) Learning mechanisms: rule-based, inductive, connectionist, parameter setting, and so on. (3) Input and feedback characteristics: learning stimuli, information about success and failure. (4) Information processing mechanisms: capacity limitations, attentional biases, response preferences. (5) Energetic variables: motivation, emotional reactions. (6) Final state: the fine-structure of kinds and levels of subskills at the end of the learning episode. This applies to language acquisition as well. First and second language learners probably differ on all six factors. Nevertheless, the debate between advocates and opponents of the Fundamental Difference Hypothesis concerning L1 and L2 acquisition have looked almost exclusively at the first two factors. Those who believe that L1 learners have access to Universal Grammar whereas L2 learners rely on language processing strategies, postulate different learning mechanisms (UG parameter setting in L1, more general inductive strategies in L2 learning). Pienemann opposes this view and, based on his Processability Theory, argues that L1 and L2 learners start out from different initial states: they come to the grammar learning task with different structural hypotheses (SOV versus SVO as basic word order of German).

Abstract

This paper is an abridged version (in Dutch) of an in-press article by the same author (Kempen, G. (2008/9). Clausal coordination and coordinate ellipsis in a model of the speaker. To be published in: Linguistics). The two papers present a psycholinguistically inspired approach to the syntax of clause-level coordination and coordinate ellipsis. It departs from the assumption that coordinations are structurally similar to so-called appropriateness repairs Ñ an important type of self-repairs in spontaneous speech. Coordinate structures and appropriateness repairs can both be viewed as ÒupdateÓ con-structions. Updating is defined as a special sentence production mode that efficiently revises or augments existing sentential structure in response to modifications in the speakerÕs communicative intention. This perspective is shown to offer an empirically satisfactory and theoretically parsimonious account of two prominent types of coordinate ellipsis, in particular Forward Conjunction Reduction (FCR) and Gapping (including Long-Distance Gapping and Subgapping). They are analyzed as different manifestations of Òincremental updatingÓ Ñ efficient updating of only part of the existing sentential structure. Based on empirical data from Dutch and German, novel treatments are proposed for both types of clausal coordinate ellipsis. Two other forms of coordinate ellipsis Ñ SGF (ÒSubject Gap in Finite clauses with fronted verbÓ), and Backward Conjunction Reduction (BCR; also known as Right Node Raising or RNR) Ñ are shown to be incompatible with the notion of incremental updating. Alternative theoretical interpretations of these phenomena are proposed. The four types of clausal coordinate ellipsis Ñ SGF, Gapping, FCR and BCR Ñ are argued to originate in four different stages of sentence production: Intending (i.e. preparing the communicative intention), Conceptualization, Grammatical Encoding, and Phonological Encoding, respectively.

Abstract

Comments on a study by Frazier and others on Dutch-language lexical processing. Claims that the control condition in the experiment was inadequate and that an assumption made by Frazier about closed class verbal items is inaccurate, and proposes an alternative account of a subset of the data from the experiment

Abstract

Raises objections to L. Frazier et al's (see record 1994-32229-001) report of an experimental study intended to test Schreuder's (1990) Morphological Integration (MI) model concerning the processing of separable and inseparable verbs and shows that the logic of the experiment is flawed. The problem is rooted in the notion of a separable complex verb. The conclusion is drawn that Frazier et al's experimental data cannot be taken as evidence for the theoretical propositions they develop about the MI model.

Abstract

Previous work has shown that Dutch listeners use prosodic information in the speech signal to optimise morphological processing: Listeners are sensitive to prosodic differences between a noun stem realised in isolation and a noun stem realised as part of a plural form (in which the stem is followed by an unstressed syllable). The present study, employing a lexical decision task, provides an additional demonstration of listeners' sensitivity to prosodic cues in the stem. This sensitivity is shown for two languages that differ in morphological productivity: Dutch and English. The degree of morphological productivity does not correlate with listeners' sensitivity to prosodic cues in the stem, but it is reflected in differential sensitivities to the word-specific log odds ratio of encountering an unshortened stem (i.e., a stem in isolation) versus encountering a shortened stem (i.e., a stem followed by a suffix consisting of one or more unstressed syllables). In addition to being sensitive to the prosodic cues themselves, listeners are also sensitive to the probabilities of occurrence of these prosodic cues.

Abstract

It has recently been shown that listeners use systematic differences in vowel length and intonation to resolve ambiguities between onset-matched simple words (Davis, Marslen-Wilson, & Gaskell, 2002; Salverda, Dahan, & McQueen, 2003). The present study shows that listeners also use prosodic information in the speech signal to optimize morphological processing. The precise acoustic realization of the stem provides crucial information to the listener about the morphological context in which the stem appears and attenuates the competition between stored inflectional variants. We argue that listeners are able to make use of prosodic information, even though the speech signal is highly variable within and between speakers, by virtue of the relative invariance of the duration of the onset. This provides listeners with a baseline against which the durational cues in a vowel and a coda can be evaluated. Furthermore, our experiments provide evidence for item-specific prosodic effects.

Abstract

Written information is often of limited accessibility to deaf people who use sign language. The eSign project was undertaken as a response to the need for technologies enabling efficient production and distribution over the Internet of sign language content. By using an avatar-independent scripting notation for signing gestures and a client-side web browser plug-in to translate this notation into motion data for an avatar, we achieve highly efficient delivery of signing, while avoiding the inflexibility of video or motion capture. Tests with members of the deaf community have indicated that the method can provide an acceptable quality of signing.

Abstract

Speech is structured into parts by syntactic and prosodic breaks. In locally syntactic ambiguous sentences, the detection of a syntactic break necessarily follows detection of a corresponding prosodic break, making an investigation of the immediate interplay of syntactic and prosodic information impossible when studying sentences in isolation. This problem can be solved, however, by embedding sentences in a discourse context that induces the expectation of either the presence or the absence of a syntactic break right at a prosodic break. Event-related potentials (ERPs) were compared to acoustically identical sentences in these different contexts. We found in two experiments that the closure positive shift, an ERP component known to be elicited by prosodic breaks, was reduced in size when a prosodic break was aligned with a syntactic break. These results establish that the brain matches prosodic information against syntactic information immediately.

Abstract

In Dutch, high-frequency words with the suffix -lijk are often highly reduced in spontaneous unscripted speech. This study addressed socio-geographic variation in the reduction of such words against the backdrop of the variation in their use in written and spoken Dutch. Multivariate analyses of the frequencies with which the words were used in a factorially contrasted set of subcorpora revealed signi ficant variation involving the speaker's country, sex, and education level for spoken Dutch, and involving country and register for written Dutch. Acoustic analyses revealed that Dutch men reduced most often, while Flemish highly educated women reduced least. Two linguistic context effects emerged, one prosodic, and the other pertaining to the flow of information. Words in sentence final position showed less reduction, while words that were better predictable from the preceding word in the sentence(based on mutual information) tended to be reduced more often. The increased probability of reduction for forms that are more predictable in context, combined with the loss of the suffix in the more extremely reduced forms, suggests that highfrequency words in -lijk are undergoing a process of erosion that causes them to gravitate towards monomorphemic function words.

Abstract

This paper reports on an investigation of children's (aged 3;5–9;8) comprehension of sentences containing ambiguity of prepositional phrase (PP) attachment. Results from a picture selection study (N=90) showed that children use verb semantics and preposition type to resolve the ambiguity, with older children also showing sensitivity to the definiteness of the object NP as a cue to interpretation. Study 2 investigated three- and five-year-old children's (N=47) ability to override an instrumental interpretation of ambiguous PPs in order to process attributes of the referential scene. The results showed that while five-year-olds are capable of incorporating aspects of the referential scene into their interpretations, three-year-olds are not as successful. Overall, the results suggest that children are attuned very early to the lexico-semantic co-occurrences that have been shown to aid ambiguity resolution in adults, but that more diffuse cues to interpretation are used only later in development

Abstract

This paper reports on two studies investigating children's and adults' processing of sentences containing ambiguity of prepositional phrase (PP) attachment. Study 1 used corpus data to investigate whether cues argued to be used by adults to resolve PP-attachment ambiguities are available in child-directed speech. Study 2 was an on-line reaction time study investigating the role of lexical and referential biases in syntactic ambiguity resolution by children and adults. Forty children (mean age 8;4) and 37 adults listened to V-NP-PP sentences containing temporary ambiguity of PP-attachment. The sentences were manipulated for (i) verb semantics, (ii) the definiteness of the object NP, and (iii) PP-attachment site. The children and adults did not differ qualitatively from each other in their resolution of the ambiguity. A verb semantics by attachment interaction suggested that different attachment analyses were pursued depending on the semantics of the verb. There was no influence of the definiteness of the object NP in either children's or adults' parsing preferences. The findings from the on-line task matched up well with the corpus data, thus identifying a role for the input in the development of parsing strategies.

Abstract

We present the results from four studies, two corpora and two experimental, which suggest that English- and German-speaking children (3;1–4;9 years) use multiple constraints to process and produce object relative clauses. Our two corpora studies show that children produce object relatives that reflect the distributional and discourse regularities of the input. Specifically, the results show that when children produce object relatives they most often do so with (a) an inanimate head noun, and (b) a pronominal relative clause subject. Our experimental findings show that children use these constraints to process and produce this construction type. Moreover, when children were required to repeat the object relatives they most often use in naturalistic speech, the subject-object asymmetry in processing of relative clauses disappeared. We also report cross-linguistic differences in children's rate of acquisition which reflect properties of the input language. Overall, our results suggest that children are sensitive to the same constraints on relative clause processing as adults.

Abstract

Gestures that accompany speech are known to be tightly coupled with speech production. However little is known about the cognitive processes that underlie this link. Previous cross-linguistic research has provided preliminary evidence for online interaction between the two systems based on the systematic co-variation found between how different languages syntactically package Manner and Path information of a motion event and how gestures represent Manner and Path. Here we elaborate on this finding by testing whether speakers within the same language gesturally express Manner and Path differently according to their online choice of syntactic packaging of Manner and Path, or whether gestural expression is pre-determined by a habitual conceptual schema congruent with the linguistic typology. Typologically congruent and incongruent syntactic structures for expressing Manner and Path (i.e., in a single clause or multiple clauses) were elicited from English speakers. We found that gestural expressions were determined by the online choice of syntactic packaging rather than by a habitual conceptual schema. It is therefore concluded that speech and gesture production processes interface online at the conceptual planning phase. Implications of the findings for models of speech and gesture production are discussed

Abstract

This task investigates the expression of “enter” and “exit” events, and is a supplement to the Motion Elicitation task (https://doi.org/10.17617/2.3003391). Consultants are asked to describe a series of animated clips where a man moves into or out of a house. The clips focus on contrasts to do with perspective (e.g., whether the man appears to move away or towards the viewer) and transitional movement (e.g., whether the man walks or “teleports” into his new location).

Abstract

The previous literature has suggested that the hand movement in co-speech gestures and signs consists of a series of phases with qualitatively different dynamic characteristics. In this paper, we propose a syntagmatic rule system for movement phases that applies to both co-speech gestures and signs. Descriptive criteria for the rule system were developed for the analysis video-recorded continuous production of signs and gesture. It involves segmenting a stream of body movement into phases and identifying different phase types. Two human coders used the criteria to analyze signs and cospeech gestures that are produced in natural discourse. It was found that the criteria yielded good inter-coder reliability. These criteria can be used for the technology of automatic recognition of signs and co-speech gestures in order to segment continuous production and identify the potentially meaningbearing phase.

Abstract

Do our hands 'speak the same language' across cultures? Gesture is the silent partner of spoken languages in face-to-face interaction, but we still have a lot to learn about gesture practices in different speech communities. The primary purpose of this task is to collect data in naturalistic settings that can be used to investigate the linguistic and cultural relativity of gesture performance, especially spatially indicative gestures. It involves video-recording pairs of speakers in both free conversation and more structured communication tasks (e.g., describing film plots).

Please note: the stimuli mentioned in this entry are available elsewhere: 'The Pear Story', a short film made at the University of California at Berkeley; "Frog, where are you?" from the original Mayer (1969) book, as published in the Appendix of Berman & Slobin (1994).

Abstract

In a way, the entire history of linguistic thought from the Antiquity to present days is a series of variations on two key themes: 1. In a certain sense, language and cognition are the same, and 2. In a certain sense, all languages are the same. What varies is the way in which “in a certain sense” is spelled out. Interpretations oscillate between radical positions such as the idea that thinking without speaking is impossible to the idea that it is just language which vexes our cognition and hence makes it rather impossible, and similarly between the idea that all differences between natural languages are nothing but irrelevant variations in the “vox”, the “external form” to the idea that it our thought is massively shaped by the particular structural features of the language we happen to speak. It is remarkable how little agreement has been reached on these issues after more than 2500 years of discussion. This, it is argued, has mainly two reasons: (a) The entire argument is largely confined to a few lexical and morphological properties of human languages, and (b) the discussion is rarely based on empirical research on “language at work” - how do we manage to solve those many little tasks for which human languages are designed in the first place.

Abstract

Language acquisition is the transition between the language faculty, with which we are born as a part of our genetic endowment, to the mastery of one or more linguistic systems. There is a plethora of findings about this process; but these findings still do not form a coherent picture of the principles which underlie this process. There are at least six reasons for this situation. First, there is an enormous variability in the conditions under which this process occurs. Second, the learning capacity does not remain constant over time. Third, the process extends over many years and is therefore hard to study. Fourth, especially the investigation of the meaning side is problem-loaded. Fifth, many skills and types of knowledge must be learned in a more or less synchronised way. And sixth, our understanding of the functioning of linguistic systems is still very limited. Nevertheless, there are a few overarching results, three of which are discussed here: (1) There are salient differences between child and adult learners: While children normally end up with perfect mastery of the language to be learned, this is hardly ever the case for adults. On the hand, it could be shown for each linguistic property examined so far, that adults are in principle able to learn it up to perfection. So, adults can learn everything perfectly well, they just don’t. (2) Within childhood, age of onset plays no essential role for ultimate attainment. (3) Children care much more for formal correctness than adults - they are just better in mimicking existing systems. It is argued that age does not affect the „construction capacity”- the capacity to build up linguistic systems - but the „copying faculty”, i.e., the faculty to imitate an existing system.

Abstract

During the last 25 years, second language acquisition (SLA) research hasmade considerable progress, but is still far from proving a solid basis for foreign language teaching, or from a general theory of SLA. In addition, its status within the linguistic disciplines is still very low. I argue this has not much to do with low empirical or theoretical standards in the field—in this regard, SLA research is fully competitive—but with a particular perspective on the acquisition process: SLA researches learners' utterances as deviations from a certain target, instead of genuine manifestations of underlying language capacity; it analyses them in terms of what they are not rather than what they are. For some purposes such a "target deviation perspective" makes sense, but it will not help SLA researchers to substantially and independently contribute to a deeper understanding of the structure and function of the human language faculty. Therefore, these findings will remain of limited interest to other scientists until SLA researchers consider learner varieties a normal, in fact typical, manifestation of this unique human capacity.

Abstract

Children begin to talk at about age one. The vocabulary they need to do so must be built on perceptual evidence and, indeed, infants begin to recognize spoken words long before they talk. Most of the utterances infants hear, however, are continuous, without pauses between words, so constructing a vocabulary requires them to decompose continuous speech in order to extract the individual words. Here, we present electrophysiological evidence that 10-month-old infants recognize two-syllable words they have previously heard only in isolation when these words are presented anew in continuous speech. Moreover, they only need roughly the first syllable of the word to begin doing this. Thus, prelinguistic infants command a highly efficient procedure for segmentation and recognition of spoken words in the absence of an existing vocabulary, allowing them to tackle effectively the problem of bootstrapping a lexicon out of the highly variable, continuous speech signals in their environment.

Abstract

Word segmentation, or detecting word boundaries in continuous speech, is not an easy task. Spoken language does not contain silences to indicate word boundaries and words partly overlap due to coarticalution. Still, adults listening to their native language perceive speech as individual words. They are able to combine different distributional cues in the language, such as the statistical distribution of sounds and metrical cues, with lexical information, to efficiently detect word boundaries. Infants in the first year of life do not command these cues. However, already between seven and ten months of age, before they know word meaning, infants learn to segment words from speech. This important step in language acquisition is the topic of this dissertation. In chapter 2, the first Event Related Brain Potential (ERP) study on word segmentation in Dutch ten-month-olds is discussed. The results show that ten-month-olds can already segment words with a strong-weak stress pattern from speech and they need roughly the first half of a word to do so. Chapter 3 deals with segmentation of words beginning with a weak syllable, as a considerable number of words in Dutch do not follow the predominant strong-weak stress pattern. The results show that ten-month-olds still largely rely on the strong syllable in the language, and do not show an ERP response to the initial weak syllable. In chapter 4, seven-month-old infants' segmentation of strong-weak words was studied. An ERP response was found to strong-weak words presented in sentences. However, a behavioral response was not found in an additional Headturn Preference Procedure study. There results suggest that the ERP response is a precursor to the behavioral response that infants show at a later age.

Abstract

Does the naming of clocks always require conceptual preparation? To examine this question, speakers were presented with analog and digital clocks that had to be named in Dutch using either a relative (e.g., “quarter to four”) or an absolute (e.g., “three forty-five”) clock time expression format. Naming latencies showed evidence of conceptual preparation when speakers produced relative time expressions to analog and digital clocks, but not when they used absolute time expressions. These findings indicate that conceptual mediation is not always mandatory for telling time, but instead depends on clock time expression format, supporting a multiple-route account of Dutch clock time naming.

Abstract

In various applications of forensic phonetics the question arises as to how far aural-perceptual speaker recognition performance is reliable. Therefore, it is necessary to examine the relationship between speaker recognition results and human perception/production abilities like musicality or speech sensitivity. In this study, performance in a speaker recognition experiment and a speech sensitivity test are correlated. The results show a moderately significant positive correlation between the two tasks. Generally, performance in the speaker recognition task was better than in the speech sensitivity test. Professionals in speech and singing yielded a more homogeneous correlation than non-experts. Training in speech as well as choir-singing seems to have a positive effect on performance in speaker recognition. It may be concluded, firstly, that in cases where the reliability of voice line-up results or the credibility of a testimony have to be considered, the speech sensitivity test could be a useful indicator. Secondly, the speech sensitivity test might be integrated into the canon of possible procedures for the accreditation of forensic phoneticians. Both tests may also be used in combination.

Abstract

* Kristiansen, M., Deriziotis, P. These authors contributed equally to this work.* - The mechanism of cell death in prion disease is unknown but is associated with the production of a misfolded conformer of the prion protein. We report that disease-associated prion protein specifically inhibits the proteolytic β subunits of the 26S proteasome. Using reporter substrates, fluorogenic peptides, and an activity probe for the β subunits, this inhibitory effect was demonstrated in pure 26S proteasome and three different cell lines. By challenge with recombinant prion and other amyloidogenic proteins, we demonstrate that only the prion protein in a nonnative β sheet conformation inhibits the 26S proteasome at stoichiometric concentrations. Preincubation with an antibody specific for aggregation intermediates abrogates this inhibition, consistent with an oligomeric species mediating this effect. We also present evidence for a direct relationship between prion neuropathology and impairment of the ubiquitin-proteasome system (UPS) in prion-infected UPS-reporter mice. Together, these data suggest a mechanism for intracellular neurotoxicity mediated by oligomers of misfolded prion protein.