Publications

Displaying 301 - 400 of 744
  • Kempen, G., & Harbusch, K. (2004). How flexible is constituent order in the midfield of German subordinate clauses?: A corpus study revealing unexpected rigidity. In Proceedings of the International Conference on Linguistic Evidence (pp. 81-85). Tübingen: University of Tübingen.
  • Kempen, G. (2004). Human grammatical coding: Shared structure formation resources for grammatical encoding and decoding. In Cuny 2004 - The 17th Annual CUNY Conference on Human Sentence Processing. March 25-27, 2004. University of Maryland (pp. 66).
  • Kempen, G., & Van Wijk, C. (1981). Leren formuleren: Hoe uit opstellen een objektieve index voor formuleervaardigheid afgeleid kan worden. Tijdschrift voor Taalbeheersing, 3, 32-44.
  • Kempen, G. (Ed.). (1987). Natural language generation: New results in artificial intelligence, psychology and linguistics. Dordrecht: Nijhoff.
  • Kempen, G. (Ed.). (1987). Natuurlijke taal en kunstmatige intelligentie: Taal tussen mens en machine. Groningen: Wolters-Noordhoff.
  • Kempen, G. (1987). Tekstverwerking: De vijfde generatie. Informatie, 29, 402-406.
  • Kempen, G., & Fokkema, S. (1981). Ten geleide. Nederlands Tijdschrift voor de Psychologie en haar Grensgebieden, 36, 345-346.
  • Kempen, G. (1998). Sentence parsing. In A. D. Friederici (Ed.), Language comprehension: A biological perspective (pp. 213-228). Berlin: Springer.
  • Kempen, G. (1981). Taalpsychologie. In H. Duijker, & P. Vroon (Eds.), Codex Psychologicus (pp. 205-221). Amsterdam: Elsevier.
  • Kemps, R. J. J. K., Ernestus, M., Schreuder, R., & Baayen, R. H. (2004). Processing reduced word forms: The suffix restoration effect. Brain and Language, 90(1-3), 117-127. doi:10.1016/S0093-934X(03)00425-5.

    Abstract

    Listeners cannot recognize highly reduced word forms in isolation, but they can do so when these forms are presented in context (Ernestus, Baayen, & Schreuder, 2002). This suggests that not all possible surface forms of words have equal status in the mental lexicon. The present study shows that the reduced forms are linked to the canonical representations in the mental lexicon, and that these latter representations induce reconstruction processes. Listeners restore suffixes that are partly or completely missing in reduced word forms. A series of phoneme-monitoring experiments reveals the nature of this restoration: the basis for suffix restoration is mainly phonological in nature, but orthography has an influence as well.
  • Kemps, R. J. J. K. (2004). Morphology in auditory lexical processing: Sensitivity to fine phonetic detail and insensitivity to suffix reduction. PhD Thesis, Radboud University Nijmegen, Nijmegen. doi:10.17617/2.59193.

    Abstract

    This dissertation investigates two seemingly contradictory properties of the speech perception system. On the one hand, listeners are extremely sensitive to the fine phonetic details in the speech signal. These subtle acoustic cues can reduce the temporal ambiguity between words that show initial segmental overlap, and can guide lexical activation. On the other hand, comprehension does not seem to be hampered at all by the drastic reductions that typically occur in casual speech. Complete segments, and sometimes even complete syllables, may be missing, but comprehension is seemingly unaffected. This thesis aims at elucidating how words are represented and accessed in the mental lexicon, by investigating these contradictory phenomena for the domain of morphology

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    full text via Radboud Repository
  • Kidd, E. (2004). Grammars, parsers, and language acquisition. Journal of Child Language, 31(2), 480-483. doi:10.1017/S0305000904006117.

    Abstract

    Drozd's critique of Crain & Thornton's (C&T) (1998) book Investigations in Universal Grammar (IUG) raises many issues concerning theory and experimental design within generative approaches to language acquisition. I focus here on one of the strongest theoretical claims of the Modularity Matching Model (MMM): continuity of processing. For reasons different to Drozd, I argue that the assumption is tenuous. Furthermore, I argue that the focus of the MMM and the methodological prescriptions contained in IUG are too narrow to capture language acquisition.
  • Kidd, E., Bavin, E. L., & Rhodes, B. (2001). Two-year-olds' knowledge of verbs and argument structures. In M. Almgren, A. Barreña, M.-J. Ezeuzabarrena, I. Idiazabal, & B. MacWhinney (Eds.), Research on child language acquisition: Proceedings of the 8th Conference of the International Association for the Study of Child language (pp. 1368-1382). Sommerville: Cascadilla Press.
  • Kircher, T. T. J., Brammer, M. J., Levelt, W. J. M., Bartels, M., & McGuire, P. K. (2004). Pausing for thought: Engagement of left temporal cortex during pauses in speech. NeuroImage, 21(1), 84-90. doi:10.1016/j.neuroimage.2003.09.041.

    Abstract

    Pauses during continuous speech, particularly those that occur within clauses, are thought to reflect the planning of forthcoming verbal output. We used functional Magnetic Resonance Imaging (fMRI) to examine their neural correlates. Six volunteers were scanned while describing seven Rorschach inkblots, producing 3 min of speech per inkblot. In an event-related design, the level of blood oxygenation level dependent (BOLD) contrast during brief speech pauses (mean duration 1.3 s, SD 0.3 s) during overt speech was contrasted with that during intervening periods of articulation. We then examined activity associated with pauses that occurred within clauses and pauses that occurred between grammatical junctions. Relative to articulation during speech, pauses were associated with activation in the banks of the left superior temporal sulcus (BA 39/22), at the temporoparietal junction. Continuous speech was associated with greater activation bilaterally in the inferior frontal (BA 44/45), middle frontal (BA 8) and anterior cingulate (BA 24) gyri, the middle temporal sulcus (BA 21/22), the occipital cortex and the cerebellum. Left temporal activation was evident during pauses that occurred within clauses but not during pauses at grammatical junctions. In summary, articulation during continuous speech involved frontal, temporal and cerebellar areas, while pausing was associated with activity in the left temporal cortex, especially when this occurred within a clause. The latter finding is consistent with evidence that within-clause pauses are a correlate of speech planning and in particular lexical retrieval.
  • Kita, S., Danziger, E., & Stolz, C. (2001). Cultural specificity of spatial schemas, as manifested in spontaneous gestures. In M. Gattis (Ed.), Spatial Schemas and Abstract Thought (pp. 115-146). Cambridge, MA, USA: MIT Press.
  • Kita, S., van Gijn, I., & van der Hulst, H. (1998). Movement phases in signs and co-speech gestures, and their transcription by human coders. In Gesture and Sign-Language in Human-Computer Interaction (Lecture Notes in Artificial Intelligence - LNCS Subseries, Vol. 1371) (pp. 23-35). Berlin, Germany: Springer-Verlag.

    Abstract

    The previous literature has suggested that the hand movement in co-speech gestures and signs consists of a series of phases with qualitatively different dynamic characteristics. In this paper, we propose a syntagmatic rule system for movement phases that applies to both co-speech gestures and signs. Descriptive criteria for the rule system were developed for the analysis video-recorded continuous production of signs and gesture. It involves segmenting a stream of body movement into phases and identifying different phase types. Two human coders used the criteria to analyze signs and cospeech gestures that are produced in natural discourse. It was found that the criteria yielded good inter-coder reliability. These criteria can be used for the technology of automatic recognition of signs and co-speech gestures in order to segment continuous production and identify the potentially meaningbearing phase.
  • Kita, S. (2001). Locally-anchored spatial gestures, version 2: Historical description of the local environment as a gesture elicitation task. In S. C. Levinson, & N. J. Enfield (Eds.), Manual for the field season 2001 (pp. 132-135). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.874647.

    Abstract

    Gesture is an integral part of face-to-face communication, and provides a rich area for cross-cultural comparison. “Locally-anchored spatial gestures” are gestures that are roughly oriented to the actual geographical direction of referents. For example, such gestures may point to a location or a thing, trace the shape of a path, or indicate the direction of a particular area. The goal of this task is to elicit locally-anchored spatial gestures across different cultures. The task follows an interview format, where one participant prompts another to talk in detail about a specific area that the main speaker knows well. The data can be used for additional purposes such as the investigation of demonstratives.
  • Kita, S. (2001). Recording recommendations for gesture studies. In S. C. Levinson, & N. J. Enfield (Eds.), Manual for the field season 2001 (pp. 130-131). Nijmegen: Max Planck Institute for Psycholinguistics.
  • Klein, W. (Ed.). (2004). Philologie auf neuen Wegen [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, 136.
  • Klein, W. (Ed.). (2004). Universitas [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik (LiLi), 134.
  • Klein, W. (2004). Vom Wörterbuch zum digitalen lexikalischen System. Zeitschrift für Literaturwissenschaft und Linguistik, 136, 10-55.
  • Klein, W., & Rath, R. (1981). Automatische Lemmatisierung deutscher Flexionsformen. In R. Herzog (Ed.), Computer in der Übersetzungswissenschaft (pp. 94-142). Framkfurt am Main, Bern: Verlag Peter Lang.
  • Klein, W. (2000). Changing concepts of the nature-nurture debate. In R. Hide, J. Mittelstrass, & W. Singer (Eds.), Changing concepts of nature at the turn of the millenium: Proceedings plenary session of the Pontifical academy of sciences, 26-29 October 1998 (pp. 289-299). Vatican City: Pontificia Academia Scientiarum.
  • Klein, W., & Levelt, W. J. M. (Eds.). (1981). Crossing the boundaries in linguistics: Studies presented to Manfred Bierwisch. Dordrecht: Reidel.
  • Klein, W. (2001). Das Ende vor Augen: Deutsch als Wissenschaftssprache. In F. Debus, F. Kollmann, & U. Pörken (Eds.), Deutsch als Wissenschaftssprache im 20. Jahrhundert (pp. 289-293). Mainz: Akademie der Wissenschaften und der Literatur.
  • Klein, W. (1987). Das Geltende, oder: System der Überzeugungen. Zeitschrift für Literaturwissenschaft und Linguistik, (64), 10-31.
  • Klein, W. (2001). Deiktische Orientierung. In M. Haspelmath, E. König, W. Oesterreicher, & W. Raible (Eds.), Sprachtypologie und sprachliche Universalien: Vol. 1/1 (pp. 575-590). Berlin: de Gruyter.
  • Klein, W. (2000). Der Mythos vom Sprachverfall. In Berlin-Brandenburgische Akademie der Wissenschaften (Ed.), Jahrbuch 1999: Berlin-Brandenburgische Akademie der Wissenschaften (pp. 139-158). Berlin: Akademie Verlag.
  • Klein, W. (1998). Ein Blick zurück auf die Varietätengrammatik. In U. Ammon, K. Mattheier, & P. Nelde (Eds.), Sociolinguistica: Internationales Jahrbuch für europäische Soziolinguistik (pp. 22-38). Tübingen: Niemeyer.
  • Klein, W. (2001). Ein Gemeinwesen, in dem das Volk herrscht, darf nicht von Gesetzen beherrscht werden, die das Volk nicht versteht. Rechtshistorisches Journal, 20, 621-628.
  • Klein, W. (1981). Eine kommentierte Bibliographie zur Computerlinguistik. In R. Herzog (Ed.), Computer in der Übersetzungswissenschaft (pp. 95-142). Frankfurt am Main: Lang.
  • Klein, W. (1987). Eine Verschärfung des Entscheidungsproblems. Rechtshistorisches Journal, 6, 209-210.
  • Klein, W. (2001). Elementary forms of linguistic organisation. In S. Ward, & J. Trabant (Eds.), The origins of language (pp. 81-102). Berlin: Mouton de Gruyter.
  • Klein, W. (2001). Die Linguistik ist anders geworden. In S. Anschütz, S. Kanngießer, & G. Rickheit (Eds.), A Festschrift for Manfred Briegel: Spektren der Linguistik (pp. 51-72). Wiesbaden: Deutscher Universitätsverlag.
  • Klein, W. (2000). An analysis of the German perfekt. Language, 76, 358-382.

    Abstract

    The German Perfekt has two quite different temporal readings, as illustrated by the two possible continuations of the sentence Peter hat gearbeitet in i, ii, respectively: (i) Peter hat gearbeitet und ist müde. Peter has worked and is tired. (ii) Peter hat gearbeitet und wollte nicht gestört werden. Peter has worked and wanted not to be disturbed. The first reading essentially corresponds to the English present perfect; the second can take a temporal adverbial with past time reference ('yesterday at five', 'when the phone rang', and so on), and an English translation would require a past tense ('Peter worked/was working'). This article shows that the Perfekt has a uniform temporal meaning that results systematically from the interaction of its three components-finiteness marking, auxiliary and past participle-and that the two readings are the consequence of a structural ambiguity. This analysis also predicts the properties of other participle constructions, in particular the passive in German.
  • Klein, W., Li, P., & Hendriks, H. (2000). Aspect and assertion in Mandarin Chinese. Natural Language & Linguistic Theory, 18, 723-770. doi:10.1023/A:1006411825993.

    Abstract

    Chinese has a number of particles such as le, guo, zai and zhe that add a particular aspectual value to the verb to which they are attached. There have been many characterisations of this value in the literature. In this paper, we review several existing influential accounts of these particles, including those in Li and Thompson (1981), Smith (1991), and Mangione and Li (1993). We argue that all these characterisations are intuitively plausible, but none of them is precise.We propose that these particles serve to mark which part of the sentence''s descriptive content is asserted, and that their aspectual value is a consequence of this function. We provide a simple and precise definition of the meanings of le, guo, zai and zhe in terms of the relationship between topic time and time of situation, and show the consequences of their interaction with different verb expressions within thisnew framework of interpretation.
  • Klein, W. (1998). Assertion and finiteness. In N. Dittmar, & Z. Penner (Eds.), Issues in the theory of language acquisition: Essays in honor of Jürgen Weissenborn (pp. 225-245). Bern: Peter Lang.
  • Klein, W. (2004). Das Digitale Wörterbuch der deutschen Sprache des 20. Jahrhunderts (DWDS). In J. Scharnhorst (Ed.), Sprachkultur und Lexikographie (pp. 281-311). Berlin: Peter Lang.
  • Klein, W. (2004). Auf der Suche nach den Prinzipien, oder: Warum die Geisteswissenschaften auf dem Rückzug sind. Zeitschrift für Literaturwissenschaft und Linguistik, 134, 19-44.
  • Klein, W. (2004). Im Lauf der Jahre. Linguistische Berichte, 200, 397-407.
  • Klein, W. (2000). Fatale Traditionen. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, (120), 11-40.
  • Klein, W. (1981). Forschungsprojekt "Zweitspracherwerb ausländischer Arbeiter". Studium Linguistik, 11, 84-89.
  • Klein, W. (1981). Knowing a language and knowing to communicate: A case study in foreign workers' communication. In A. Vermeer (Ed.), Language problems of minority groups (pp. 75-95). Tilburg: Tilburg University.
  • Klein, W. (1981). L'acquisition des pronoms personnels allemands par des travailleurs espagnols et italiens. GRECO, 13, 19-31.
  • Klein, W. (1987). L'espressione della temporalita in una varieta elementare di L2. In A. Ramat (Ed.), L'apprendimento spontaneo di una seconda lingua (pp. 131-146). Bologna: Molino.
  • Klein, W. (2001). Lexicology and lexicography. In N. Smelser, & P. Baltes (Eds.), International encyclopedia of the social & behavioral sciences: Vol. 13 (pp. 8764-8768). Amsterdam: Elsevier Science.
  • Klein, W. (1981). Logik der Argumentation. In Institut für deutsche Sprache (Ed.), Dialogforschung: Jahrbuch 1980 des Instituts für deutsche Sprache (pp. 226-264). Düsseldorf: Schwann.
  • Klein, W. (Ed.). (1998). Kaleidoskop [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (112).
  • Klein, W. (2000). Prozesse des Zweitspracherwerbs. In H. Grimm (Ed.), Enzyklopädie der Psychologie: Vol. 3 (pp. 538-570). Göttingen: Hogrefe.
  • Klein, W., & Von Stutterheim, C. (1987). Quaestio und referentielle Bewegung in Erzählungen. Linguistische Berichte, 109, 163-183.
  • Klein, W. (1998). The contribution of second language acquisition research. Language Learning, 48, 527-550. doi:10.1111/0023-8333.00057.

    Abstract

    During the last 25 years, second language acquisition (SLA) research hasmade considerable progress, but is still far from proving a solid basis for foreign language teaching, or from a general theory of SLA. In addition, its status within the linguistic disciplines is still very low. I argue this has not much to do with low empirical or theoretical standards in the field—in this regard, SLA research is fully competitive—but with a particular perspective on the acquisition process: SLA researches learners' utterances as deviations from a certain target, instead of genuine manifestations of underlying language capacity; it analyses them in terms of what they are not rather than what they are. For some purposes such a "target deviation perspective" makes sense, but it will not help SLA researchers to substantially and independently contribute to a deeper understanding of the structure and function of the human language faculty. Therefore, these findings will remain of limited interest to other scientists until SLA researchers consider learner varieties a normal, in fact typical, manifestation of this unique human capacity.
  • Klein, W. (1981). Some rules of regular ellipsis in German. In W. Klein, & W. J. M. Levelt (Eds.), Crossing the boundaries in linguistics: Studies presented to Manfred Bierwisch (pp. 51-78). Dordrecht: Reidel.
  • Klein, W. (Ed.). (2000). Sprache des Rechts [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (118).
  • Klein, W., & Berliner Arbeitsgruppe (2000). Sprache des Rechts: Vermitteln, Verstehen, Verwechseln. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, (118), 7-33.
  • Klein, W. (Ed.). (1987). Sprache und Ritual [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (65).
  • Klein, W. (2001). Second language acquisition. In N. Smelser, & P. Baltes (Eds.), International encyclopedia of the social & behavioral sciences: Vol. 20 (pp. 13768-13771). Amsterdam: Elsevier science.
  • Klein, W., & Vater, H. (1998). The perfect in English and German. In L. Kulikov, & H. Vater (Eds.), Typology of verbal categories: Papers presented to Vladimir Nedjalkov on the occasion of his 70th birthday (pp. 215-235). Tübingen: Niemeyer.
  • Klein, W. (2004). Was die Geisteswissenschaften leider noch von den Naturwissenschaften unterscheidet. Gegenworte, 13, 79-84.
  • Klein, W. (2000). Was uns die Sprache des Rechts über die Sprache sagt. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, (118), 115-149.
  • Klein, W. (2001). Time and again. In C. Féry, & W. Sternefeld (Eds.), Audiatur vox sapientiae: A festschrift for Arnim von Stechow (pp. 267-286). Berlin: Akademie Verlag.
  • Klein, W. (2001). Typen und Konzepte des Spracherwerbs. In L. Götze, G. Helbig, G. Henrici, & H. Krumm (Eds.), Deutsch als Fremdsprache (pp. 604-616). Berlin: de Gruyter.
  • Klein, W. (1998). Von der einfältigen Wißbegierde. Zeitschrift für Literaturwissenschaft und Linguistik, 112, 6-13.
  • Knösche, T. R., & Bastiaansen, M. C. M. (2001). Does the Hilbert transform improve accuracy and time resolution of ERD/ERS? Biomedizinische Technik, 46(2), 106-108.
  • Köster, O., Hess, M. M., Schiller, N. O., & Künzel, H. J. (1998). The correlation between auditory speech sensitivity and speaker recognition ability. Forensic Linguistics: The international Journal of Speech, Language and the Law, 5, 22-32.

    Abstract

    In various applications of forensic phonetics the question arises as to how far aural-perceptual speaker recognition performance is reliable. Therefore, it is necessary to examine the relationship between speaker recognition results and human perception/production abilities like musicality or speech sensitivity. In this study, performance in a speaker recognition experiment and a speech sensitivity test are correlated. The results show a moderately significant positive correlation between the two tasks. Generally, performance in the speaker recognition task was better than in the speech sensitivity test. Professionals in speech and singing yielded a more homogeneous correlation than non-experts. Training in speech as well as choir-singing seems to have a positive effect on performance in speaker recognition. It may be concluded, firstly, that in cases where the reliability of voice line-up results or the credibility of a testimony have to be considered, the speech sensitivity test could be a useful indicator. Secondly, the speech sensitivity test might be integrated into the canon of possible procedures for the accreditation of forensic phoneticians. Both tests may also be used in combination.
  • Krämer, I. (1998). Children's interpretations of indefinite object noun phrases. Linguistics in the Netherlands, 1998, 163-174. doi:10.1075/avt.15.15kra.
  • Krämer, I. (2000). Interpreting indefinites: An experimental study of children's language comprehension. PhD Thesis, University of Utrecht, Utrecht. doi:10.17617/2.2057626.
  • Krott, A., Hagoort, P., & Baayen, R. H. (2004). Sublexical units and supralexical combinatories in the processing of interfixed Dutch compounds. Language and Cognitive Processes, 19(3), 453-471. doi:10.1080/769813936.

    Abstract

    This study addresses the supralexical inferential processes underlying wellformedness judgements and latencies for a specic sublexical unit that appears in Dutch compounds, the interfix. Production studies have shown that the selection of interfixes in novel Dutch compounds and the speed of
    this selection is primarily determined by the distribution of interfixes in existing compounds that share the left constituent with the target compound, i.e. the ‘‘left constituent family’’. In this paper, we consider the question whether constituent families also affect wellformedness decisions of novel as well as existing Dutch compounds in comprehension. We visually presented compounds containing interfixes that were either in line with the bias of the left constituent family or not. In the case of existing compounds, we also presented variants with replaced interfixes. As in production, the bias of the left constituent family emerged as a crucial predictor for both acceptance rates and response latencies. This result supports the hypothesis that, as in production, constituent families are (co-)activated in comprehension. We argue that this co-activation is part of a supralexical inferential process, and we discuss how our data might be interpreted within sublexical and supralexical theories of morphological processing.
  • Krott, A., Libben, G., Jarema, G., Dressler, W., Schreuder, R., & Baayen, R. H. (2004). Probability in the grammar of German and Dutch: Interfixation in triconstituent compounds. Language and Speech, 47(1), 83-106.

    Abstract

    This study addresses the possibility that interfixes in multiconstituent nominal compounds in German and Dutch are functional as markers of immediate constituent structure.We report a lexical statistical survey of interfixation in the lexicons of German and Dutch which shows that all interfixes of German and one interfix of Dutch are significantly more likely to appear at the major constituent boundary than expected under chance conditions. A series of experiments provides evidence that speakers of German and Dutch are sensitive to the probabilistic cues to constituent structure provided by the interfixes. Thus, our data provide evidence that probability is part and parcel of grammatical competence.
  • Krott, A. (2001). Analogy in morphology: The selection of linking elements in Dutch compounds. PhD Thesis, Radboud University Nijmegen, Nijmegen. doi:10.17617/2.2057602.
  • Kuijpers, C. T., Coolen, R., Houston, D., & Cutler, A. (1998). Using the head-turning technique to explore cross-linguistic performance differences. In C. Rovee-Collier, L. Lipsitt, & H. Hayne (Eds.), Advances in infancy research: Vol. 12 (pp. 205-220). Stamford: Ablex.
  • Lai, C. S. L., Fisher, S. E., Hurst, J. A., Vargha-Khadem, F., & Monaco, A. P. (2001). A forkhead-domain gene is mutated in a severe speech and language disorder[Letters to Nature]. Nature, 413, 519-523. doi:10.1038/35097076.

    Abstract

    Individuals affected with developmental disorders of speech and language have substantial difficulty acquiring expressive and/or receptive language in the absence of any profound sensory or neurological impairment and despite adequate intelligence and opportunity. Although studies of twins consistently indicate that a significant genetic component is involved, most families segregating speech and language deficits show complex patterns of inheritance, and a gene that predisposes individuals to such disorders has not been identified. We have studied a unique three-generation pedigree, KE, in which a severe speech and language disorder is transmitted as an autosomal-dominant monogenic trait. Our previous work mapped the locus responsible, SPCH1, to a 5.6-cM interval of region 7q31 on chromosome 7 (ref. 5). We also identified an unrelated individual, CS, in whom speech and language impairment is associated with a chromosomal translocation involving the SPCH1 interval. Here we show that the gene FOXP2, which encodes a putative transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain, is directly disrupted by the translocation breakpoint in CS. In addition, we identify a point mutation in affected members of the KE family that alters an invariant amino-acid residue in the forkhead domain. Our findings suggest that FOXP2 is involved in the developmental process that culminates in speech and language
  • Lai, C. S. L., Fisher, S. E., Hurst, J. A., Levy, E. R., Hodgson, S., Fox, M., Jeremiah, S., Povey, S., Jamison, D. C., Green, E. D., Vargha-Khadem, F., & Monaco, A. P. (2000). The SPCH1 region on human 7q31: Genomic characterization of the critical interval and localization of translocations associated with speech and language disorder. American Journal of Human Genetics, 67(2), 357-368. doi:10.1086/303011.

    Abstract

    The KE family is a large three-generation pedigree in which half the members are affected with a severe speech and language disorder that is transmitted as an autosomal dominant monogenic trait. In previously published work, we localized the gene responsible (SPCH1) to a 5.6-cM region of 7q31 between D7S2459 and D7S643. In the present study, we have employed bioinformatic analyses to assemble a detailed BAC-/PAC-based sequence map of this interval, containing 152 sequence tagged sites (STSs), 20 known genes, and >7.75 Mb of completed genomic sequence. We screened the affected chromosome 7 from the KE family with 120 of these STSs (average spacing <100 kb), but we did not detect any evidence of a microdeletion. Novel polymorphic markers were generated from the sequence and were used to further localize critical recombination breakpoints in the KE family. This allowed refinement of the SPCH1 interval to a region between new markers 013A and 330B, containing ∼6.1 Mb of completed sequence. In addition, we have studied two unrelated patients with a similar speech and language disorder, who have de novo translocations involving 7q31. Fluorescence in situ hybridization analyses with BACs/PACs from the sequence map localized the t(5;7)(q22;q31.2) breakpoint in the first patient (CS) to a single clone within the newly refined SPCH1 interval. This clone contains the CAGH44 gene, which encodes a brain-expressed protein containing a large polyglutamine stretch. However, we found that the t(2;7)(p23;q31.3) breakpoint in the second patient (BRD) resides within a BAC clone mapping >3.7 Mb distal to this, outside the current SPCH1 critical interval. Finally, we investigated the CAGH44 gene in affected individuals of the KE family, but we found no mutations in the currently known coding sequence. These studies represent further steps toward the isolation of the first gene to be implicated in the development of speech and language.
  • De Lange, F. P., Kalkman, J. S., Bleijenberg, G., Hagoort, P., Van der Werf, S. P., Van der Meer, J. W. M., & Toni, I. (2004). Neural correlates of the chronic fatigue syndrom: An fMRI study. Brain, 127(9), 1948-1957. doi:10.1093/brain/awh225.

    Abstract

    Chronic fatigue syndrome (CFS) is characterized by a debilitating fatigue of unknown aetiology. Patients who suffer from CFS report a variety of physical complaints as well as neuropsychological complaints. Therefore, it is conceivable that the CNS plays a role in the pathophysiology of CFS. The purpose of this study was to investigate neural correlates of CFS, and specifically whether there exists a linkage between disturbances in the motor system and CFS. We measured behavioural performance and cerebral activity using rapid event-related functional MRI in 16 CFS patients and 16 matched healthy controls while they were engaged in a motor imagery task and a control visual imagery task. CFS patients were considerably slower on performance of both tasks, but the increase in reaction time with increasing task load was similar between the groups. Both groups used largely overlapping neural resources. However, during the motor imagery task, CFS patients evoked stronger responses in visually related structures. Furthermore, there was a marked between-groups difference during erroneous performance. In both groups, dorsal anterior cingulate cortex was specifically activated during error trials. Conversely, ventral anterior cingulate cortex was active when healthy controls made an error, but remained inactive when CFS patients made an error. Our results support the notion that CFS may be associated with dysfunctional motor planning. Furthermore, the between-groups differences observed during erroneous performance point to motivational disturbances as a crucial component of CFS.
  • Lansner, A., Sandberg, A., Petersson, K. M., & Ingvar, M. (2000). On forgetful attractor network memories. In H. Malmgren, M. Borga, & L. Niklasson (Eds.), Artificial neural networks in medicine and biology: Proceedings of the ANNIMAB-1 Conference, Göteborg, Sweden, 13-16 May 2000 (pp. 54-62). Heidelberg: Springer Verlag.

    Abstract

    A recurrently connected attractor neural network with a Hebbian learning rule is currently our best ANN analogy for a piece cortex. Functionally biological memory operates on a spectrum of time scales with regard to induction and retention, and it is modulated in complex ways by sub-cortical neuromodulatory systems. Moreover, biological memory networks are commonly believed to be highly distributed and engage many co-operating cortical areas. Here we focus on the temporal aspects of induction and retention of memory in a connectionist type attractor memory model of a piece of cortex. A continuous time, forgetful Bayesian-Hebbian learning rule is described and compared to the characteristics of LTP and LTD seen experimentally. More generally, an attractor network implementing this learning rule can operate as a long-term, intermediate-term, or short-term memory. Modulation of the print-now signal of the learning rule replicates some experimental memory phenomena, like e.g. the von Restorff effect.
  • Lausberg, H., & Kita, S. (2001). Hemispheric specialization in nonverbal gesticulation investigated in patients with callosal disconnection. In C. Cavé, I. Guaïtella, & S. Santi (Eds.), Oralité et gestualité: Interactions et comportements multimodaux dans la communication. Actes du colloque ORAGE 2001 (pp. 266-270). Paris, France: Éditions L'Harmattan.
  • Ledberg, A., Fransson, P., Larsson, J., & Petersson, K. M. (2001). A 4D approach to the analysis of functional brain images: Application to fMRI data. Human Brain Mapping, 13, 185-198. doi:10.1002/hbm.1032.

    Abstract

    This paper presents a new approach to functional magnetic resonance imaging (FMRI) data analysis. The main difference lies in the view of what comprises an observation. Here we treat the data from one scanning session (comprising t volumes, say) as one observation. This is contrary to the conventional way of looking at the data where each session is treated as t different observations. Thus instead of viewing the v voxels comprising the 3D volume of the brain as the variables, we suggest the usage of the vt hypervoxels comprising the 4D volume of the brain-over-session as the variables. A linear model is fitted to the 4D volumes originating from different sessions. Parameter estimation and hypothesis testing in this model can be performed with standard techniques. The hypothesis testing generates 4D statistical images (SIs) to which any relevant test statistic can be applied. In this paper we describe two test statistics, one voxel based and one cluster based, that can be used to test a range of hypotheses. There are several benefits in treating the data from each session as one observation, two of which are: (i) the temporal characteristics of the signal can be investigated without an explicit model for the blood oxygenation level dependent (BOLD) contrast response function, and (ii) the observations (sessions) can be assumed to be independent and hence inference on the 4D SI can be made by nonparametric or Monte Carlo methods. The suggested 4D approach is applied to FMRI data and is shown to accurately detect the expected signal
  • Levelt, W. J. M., Meyer, A. S., & Roelofs, A. (2004). Relations of lexical access to neural implementation and syntactic encoding [author's response]. Behavioral and Brain Sciences, 27, 299-301. doi:10.1017/S0140525X04270078.

    Abstract

    How can one conceive of the neuronal implementation of the processing model we proposed in our target article? In his commentary (Pulvermüller 1999, reprinted here in this issue), Pulvermüller makes various proposals concerning the underlying neural mechanisms and their potential localizations in the brain. These proposals demonstrate the compatibility of our processing model and current neuroscience. We add further evidence on details of localization based on a recent meta-analysis of neuroimaging studies of word production (Indefrey & Levelt 2000). We also express some minor disagreements with respect to Pulvermüller’s interpretation of the “lemma” notion, and concerning his neural modeling of phonological code retrieval. Branigan & Pickering discuss important aspects of syntactic encoding, which was not the topic of the target article. We discuss their well-taken proposal that multiple syntactic frames for a single verb lemma are represented as independent nodes, which can be shared with other verbs, such as accounting for syntactic priming in speech production. We also discuss how, in principle, the alternative multiple-frame-multiplelemma account can be tested empirically. The available evidence does not seem to support that account.
  • Levelt, W. J. M. (2004). Speech, gesture and the origins of language. European Review, 12(4), 543-549. doi:10.1017/S1062798704000468.

    Abstract

    During the second half of the 19th century, the psychology of language was invented as a discipline for the sole purpose of explaining the evolution of spoken language. These efforts culminated in Wilhelm Wundt’s monumental Die Sprache of 1900, which outlined the psychological mechanisms involved in producing utterances and considered how these mechanisms could have evolved. Wundt assumes that articulatory movements were originally rather arbitrary concomitants of larger, meaningful expressive bodily gestures. The sounds such articulations happened to produce slowly acquired the meaning of the gesture as a whole, ultimately making the gesture superfluous. Over a century later, gestural theories of language origins still abound. I argue that such theories are unlikely and wasteful, given the biological, neurological and genetic evidence.
  • Levelt, W. J. M. (2000). Uit talloos veel miljoenen. Natuur & Techniek, 68(11), 90.
  • Levelt, W. J. M. (2001). The architecture of normal spoken language use. In G. Gupta (Ed.), Cognitive science: Issues and perspectives (pp. 457-473). New Delhi: Icon Publications.
  • Levelt, W. J. M. (2004). Een huis voor kunst en wetenschap. Boekman: Tijdschrift voor Kunst, Cultuur en Beleid, 16(58/59), 212-215.
  • Levelt, W. J. M., Mills, A., & Karmiloff-Smith, A. (1981). Child language research in ESF Countries: An inventory. Strasbourg: European Science Foundation.
  • Levelt, W. J. M. (2001). De vlieger die (onverwacht) wel opgaat. Natuur & Techniek, 69(6), 60.
  • Levelt, W. J. M. (2001). Defining dyslexia. Science, 292, 1300-1301.
  • Levelt, W. J. M. (1981). Déjà vu? Cognition, 10, 187-192. doi:10.1016/0010-0277(81)90044-5.
  • Levelt, W. J. M. (2000). Dyslexie. Natuur & Techniek, 68(4), 64.
  • Levelt, W. J. M., Praamstra, P., Meyer, A. S., Helenius, P., & Salmelin, R. (1998). An MEG study of picture naming. Journal of Cognitive Neuroscience, 10(5), 553-567. doi:10.1162/089892998562960.

    Abstract

    The purpose of this study was to relate a psycholinguistic processing model of picture naming to the dynamics of cortical activation during picture naming. The activation was recorded from eight Dutch subjects with a whole-head neuromagnetometer. The processing model, based on extensive naming latency studies, is a stage model. In preparing a picture's name, the speaker performs a chain of specific operations. They are, in this order, computing the visual percept, activating an appropriate lexical concept, selecting the target word from the mental lexicon, phonological encoding, phonetic encoding, and initiation of articulation. The time windows for each of these operations are reasonably well known and could be related to the peak activity of dipole sources in the individual magnetic response patterns. The analyses showed a clear progression over these time windows from early occipital activation, via parietal and temporal to frontal activation. The major specific findings were that (1) a region in the left posterior temporal lobe, agreeing with the location of Wernicke's area, showed prominent activation starting about 200 msec after picture onset and peaking at about 350 msec, (i.e., within the stage of phonological encoding), and (2) a consistent activation was found in the right parietal cortex, peaking at about 230 msec after picture onset, thus preceding and partly overlapping with the left temporal response. An interpretation in terms of the management of visual attention is proposed.
  • Levelt, W. J. M. (1966). Generatieve grammatica en psycholinguïstiek I: Inleiding in de generatieve grammatica. Nederlands Tijdschrift voor de Psychologie en haar Grensgebieden, 21, 317-337.
  • Levelt, W. J. M. (1966). Generatieve grammatica en psycholinguïstiek II. Psycholinguïstisch onderzoek. Nederlands Tijdschrift voor de Psychologie en haar Grensgebieden, 21, 367-400.
  • Levelt, W. J. M. (2000). Met twee woorden spreken [Simon Dik Lezing 2000]. Amsterdam: Vossiuspers AUP.
  • Levelt, W. J. M. (1962). Motion breaking and the perception of causality. In A. Michotte (Ed.), Causalité, permanence et réalité phénoménales: Etudes de psychologie expérimentale (pp. 244-258). Louvain: Publications Universitaires.
  • Levelt, W. J. M., & Plomp, R. (1962). Musical consonance and critical bandwidth. In Proceedings of the 4th International Congress Acoustics (pp. 55-55).
  • Levelt, W. J. M. (2004). Language. In G. Adelman, & B. H. Smith (Eds.), Elsevier's encyclopedia of neuroscience [CD-ROM] (3rd). Amsterdam: Elsevier.
  • Levelt, W. J. M., & Plomp, R. (1966). Les dimensions dans la perception des intervalles musicaux. Sciences de l'art, 3, 172-182.
  • Levelt, W. J. M. (1987). Hochleistung in Millisekunden - Sprechen und Sprache verstehen. In Jahrbuch der Max-Planck-Gesellschaft (pp. 61-77). Göttingen: Vandenhoeck & Ruprecht.
  • Levelt, W. J. M., & Maassen, B. (1981). Lexical search and order of mention in sentence production. In W. Klein, & W. J. M. Levelt (Eds.), Crossing the boundaries in linguistics (pp. 221-252). Dordrecht: Reidel.
  • Levelt, W. J. M. (2000). Links en rechts: Waarom hebben we zo vaak problemen met die woorden? Natuur & Techniek, 68(7/8), 90.
  • Levelt, W. J. M. (2000). Introduction Section VII: Language. In M. S. Gazzaniga (Ed.), The new cognitive neurosciences; 2nd ed. (pp. 843-844). Cambridge: MIT Press.
  • Levelt, W. J. M., & Schiller, N. O. (1998). Is the syllable frame stored? [Commentary on the BBS target article 'The frame/content theory of evolution of speech production' by Peter F. McNeilage]. Behavioral and Brain Sciences, 21, 520.

    Abstract

    This commentary discusses whether abstract metrical frames are stored. For stress-assigning languages (e.g., Dutch and English), which have a dominant stress pattern, metrical frames are stored only for words that deviate from the default stress pattern. The majority of the words in these languages are produced without retrieving any independent syllabic or metrical frame.
  • Levelt, W. J. M. (2000). Psychology of language. In K. Pawlik, & M. R. Rosenzweig (Eds.), International handbook of psychology (pp. 151-167). London: SAGE publications.

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