Publications

Abstract

This study uses resting state EEG data from 103 bilinguals to understand how determinants of bilingualism may
reshape the mind/brain. Participants completed the LSBQ, which quantifies language use and crucially the di-
vision of labor of dual-language use in diverse activities and settings over the lifespan. We hypothesized cor-
relations between the degree of active bilingualism with power of neural oscillations in specific frequency bands.
Moreover, we anticipated levels of mean coherence (connectivity between brain regions) to vary by degree of
bilingual language experience. Results demonstrated effects of Age of L2/2L1 onset on high beta and gamma
powers. Higher usage of the non-societal language at home and society modulated indices of functional con-
nectivity in theta, alpha and gamma frequencies. Results add to the emerging literature on the neuromodulatory
effects of bilingualism for rs-EEG, and are in line with claims that bilingualism effects are modulated by degree of
engagement with dual-language experiential factors

Abstract

Visual images contain redundant information across spatial scales where low spatial frequency contrast is informative towards the location and likely content of high spatial frequency detail. Previous research suggests that the visual system makes use of those redundancies to facilitate efficient processing. In this framework, a fast, initial analysis of low-spatial frequency (LSF) information guides the slower and later processing of high spatial frequency (HSF) detail. Here, we used multivariate classification as well as time-frequency analysis of MEG responses to the viewing of intact and phase scrambled images of human faces to demonstrate that the availability of redundant LSF information, as found in broadband intact images, correlates with a reduction in HSF representational dominance in both early and higher-level visual areas as well as a reduction of gamma-band power in early visual cortex. Our results indicate that the cross spatial frequency information redundancy that can be found in all natural images might be a driving factor in the efficient integration of fine image details.

Abstract

It has been suggested that placebo analgesia involves both higher order cognitive networks and endogenous opioid systems. The rostral anterior cingulate cortex (rACC) and the brainstem are implicated in opioid analgesia, suggesting a similar role for these structures in placebo analgesia. Using positron emission tomography, we confirmed that both opioid and placebo analgesia are associated with increased activity in the rACC. We also observed a covariation between the activity in the rACC and the brainstem during both opioid and placebo analgesia, but not during the pain-only condition. These findings indicate a related neural mechanism in placebo and opioid analgesia.

Abstract

It has been suggested that placebo analgesia involves both higher order cognitive networks and endogenous opioid systems. The rostral anterior cingulate cortex (rACC) and the brainstem are implicated in opioid analgesia, suggesting a similar role for these structures in placebo analgesia. Using positron emission tomography, we confirmed that both opioid and placebo analgesia are associated with increased activity in the rACC. We also observed a covariation between the activity in the rACC and the brainstem during both opioid and placebo analgesia, but not during the pain-only condition. These findings indicate a related neural mechanism in placebo and opioid analgesia.

Abstract

Several functional imaging studies of pain, using a number of different experimental paradigms and a variety of reference states, have failed to detect activations in the somatosensory cortices, while other imaging studies of pain have reported significant activations in these regions. The role of the somatosensory areas in pain processing has therefore been debated. In the present study the left hand was immersed in painfully cold water (standard cold pressor test) and in nonpainfully cold water during 2 min, and PET-scans were obtained either during the first or the second minute of stimulation. We observed no significant increase of activity in the somatosensory regions when the painful conditions were directly compared with the control conditions. In order to better understand the role of the primary somatosensory cortex (S1) in pain processing we used a regression analysis to study the relation between a ROI (region of interest) in the somatotopic S1-area for the stimulated hand and other regions known to be involved in pain processing. We hypothesized that although no increased activity was observed in the S1 during pain, this region would change its covariation pattern during noxious input as compared to the control stimulation if it is involved in or affected by the processing of pain. In the nonpainful cold conditions widespread regions of the ipsilateral and contralateral somatosensory cortex showed a positive covariation with the activity in the S1-ROI. However, during the first and second minute of pain this regression was significantly attenuated. During the second minute of painful stimulation there was a significant positive covariation between the activity in the S1-ROI and the other regions that are known to be involved in pain processing. Importantly, this relation was significantly stronger for the insula and the orbitofrontal cortex bilaterally when compared to the nonpainful state. The results indicate that the S1-cortex may be engaged in or affected by the processing of pain although no differential activity is observed when pain is compared with the reference condition.

Abstract

In The Netherlands, grammar teaching is an especially important subject in the curriculum of children aged 10-15 for several reasons. However, in spite of all attention and time invested, the results are poor. This article describes the problems and our attempt to overcome them by developing an intelligent computational instructional environment consisting of: a linguistic expert system, containing a module representing grammar and spelling rules and a number of modules to manipulate these rules; a didactic module; and a student interface with special facilities for grammar and spelling. Three prototypes of the functionality are discussed: BOUWSTEEN and COGO, which are programs for constructing and analyzing Dutch sentences; and TDTDT, a program for the conjugation of Dutch verbs.

Abstract

Cognitively demanding experiences, including complex skill acquisition and processing, have been
shown to induce brain adaptations, at least at the macroscopic level, e.g. on brain volume and/or
functional connectivity. However, the neurobiological bases of these adaptations, including at the
cellular level, are unclear and understudied. Here we use bilingualism as a case study to investigate
the metabolic correlates of experience-based brain adaptations. We employ Magnetic Resonance
Spectroscopy to measure metabolite concentrations in the basal ganglia, a region critical to language
control which is reshaped by bilingualism. Our results show increased myo-Inositol and decreased
N-acetyl aspartate concentrations in bilinguals compared to monolinguals. Both metabolites are
linked to synaptic pruning, a process underlying experience-based brain restructuring. Interestingly,
both concentrations correlate with relative amount of bilingual engagement. This suggests that
degree of long-term cognitive experiences matters at the level of metabolic concentrations, which
might accompany, if not drive, macroscopic brain adaptations.

Abstract

Language is infinitely productive because syntax defines dependencies between grammatical categories of words and constituents, so there is interchangeability of these words and constituents within syntactic structures. Previous laboratory-based studies of language learning have shown that complex language structures like hierarchical center embeddings (HCE) are very hard to learn, but these studies tend to simplify the language learning task, omitting semantics and focusing either on learning dependencies between individual words or on acquiring the category membership of those words. We tested whether categories of words and dependencies between these categories and between constituents, could be learned simultaneously in an artificial language with HCE’s, when accompanied by scenes illustrating the sentence’s intended meaning. Across four experiments, we showed that participants were able to learn the HCE language varying words across categories and category-dependencies, and constituents across constituents-dependencies. They also were able to generalize the learned structure to novel sentences and novel scenes that they had not previously experienced. This simultaneous learning resulting in a productive complex language system, may be a consequence of grounding complex syntax acquisition in semantics.

Abstract

When assessing dangerousness of mentally ill persons with the objective of making a decision on civil commitment, medical and legal experts use information typically belonging to their professional frame of reference. This is investigated in two studies of the commitment decision. It is hypothesized that an ‘expertise bias’ may explain differences between the medical and the legal expert in defining the dangerousness concept (study 1), and in assessing the seriousness of the danger (study 2). Judges define dangerousness more often as harming others, whereas psychiatrists more often include harm to self in the definition. In assessing the seriousness of the danger, experts tend to be more tolerant with regard to false negatives, as the type of behavior is more familiar to them. The theoretical and practical implications of the results are discussed.

Abstract

Participants performed an artificial grammar learning task, in which the standard finite
state grammar (J. Verb. Learn. Verb. Behavior 6 (1967) 855) was extended with a recursive
rule generating self-embedded sequences. We studied the learnability of such a rule in two experiments.
The results verify the general hypothesis that recursivity can be learned in an artificial
grammar learning task. However this learning seems to be rather based on recognising
chunks than on abstract rule induction. First, performance was better for strings with more
than one level of self-embedding in the sequence, uncovering more clearly the self-embedding
pattern. Second, the infinite repeatability of the recursive rule application was not spontaneously
induced from the training, but it was when an additional cue about this possibility was
given. Finally, participants were able to verbalise their knowledge of the fragments making up
the sequences––especially in the crucial front and back positions––, whereas knowledge of the
underlying structure, to the extent it was acquired, was not articulatable. The results are discussed
in relation to previous studies on the implicit learnability of complex and abstract rules.

Abstract

Objective: Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here we performed the largest-ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium.
Methods: We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modelling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries.
Results: There was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t=2.1, P=0.04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t=2.7, P=0.01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen’s d from -0.18 to 0.18) and would not survive study-wide correction for multiple testing.
Conclusion: Prior studies of altered structural brain asymmetry in ADHD were likely under-powered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.

Abstract

Silent gestures consist of complex multi-articulatory movements but are now primarily studied through categorical coding of the referential gesture content. The relation of categorical linguistic content with continuous kinematics is therefore poorly understood. Here, we reanalyzed the video data from a gestural evolution experiment (Motamedi, Schouwstra, Smith, Culbertson, & Kirby, 2019), which showed increases in the systematicity of gesture content over time. We applied computer vision techniques to quantify the kinematics of the original data. Our kinematic analyses demonstrated that gestures become more efficient and less complex in their kinematics over generations of learners. We further detect the systematicity of gesture form on the level of thegesture kinematic interrelations, which directly scales with the systematicity obtained on semantic coding of the gestures. Thus, from continuous kinematics alone, we can tap into linguistic aspects that were previously only approachable through categorical coding of meaning. Finally, going beyond issues of systematicity, we show how unique gesture kinematic dialects emerged over generations as isolated chains of participants gradually diverged over iterations from other chains. We, thereby, conclude that gestures can come to embody the linguistic system at the level of interrelationships between communicative tokens, which should calibrate our theories about form and linguistic content.

Abstract

It is now widely accepted that the brunt of animal communication is conducted via several modalities, e.g. acoustic and visual, either simultaneously or sequentially. This is a laudable multimodal turn relative to traditional accounts of temporal aspects of animal communication which have focused on a single modality at a time. However, the fields that are currently contributing to the study of multimodal communication are highly varied, and still largely disconnected given their sole focus on a particular level of description or their particular concern with human or non-human animals. Here, we provide an integrative overview of converging findings that show how multimodal processes occurring at neural, bodily, as well as social interactional levels each contribute uniquely to the complex rhythms that characterize communication in human and non-human animals. Though we address findings for each of these levels independently, we conclude that the most important challenge in this field is to identify how processes at these different levels connect.

Abstract

Communicative hand gestures are often coordinated with prosodic aspects of speech, and salient moments of gestural movement (e.g., quick changes in speed) often co-occur with salient moments in speech (e.g., near peaks in fundamental frequency and intensity). A common understanding is that such gesture and speech coordination is culturally and cognitively acquired, rather than having a biological basis. Recently, however, the biomechanical physical coupling of arm movements to speech movements has been identified as a potentially important factor in understanding the emergence of gesture-speech coordination. Specifically, in the case of steady-state vocalization and mono-syllable utterances, forces produced during gesturing are transferred onto the tensioned body, leading to changes in respiratory-related activity and thereby affecting vocalization F0 and intensity. In the current experiment (N = 37), we extend this previous line of work to show that gesture-speech physics impacts fluent speech, too. Compared with non-movement, participants who are producing fluent self-formulated speech, while rhythmically moving their limbs, demonstrate heightened F0 and amplitude envelope, and such effects are more pronounced for higher-impulse arm versus lower-impulse wrist movement. We replicate that acoustic peaks arise especially during moments of peak-impulse (i.e., the beat) of the movement, namely around deceleration phases of the movement. Finally, higher deceleration rates of higher-mass arm movements were related to higher peaks in acoustics. These results confirm a role for physical-impulses of gesture affecting the speech system. We discuss the implications of
gesture-speech physics for understanding of the emergence of communicative gesture, both ontogenetically and phylogenetically.

Abstract

Brain connectivity plays a major role in the encoding, transfer, and
integration of sensory information. Interregional synchronization
of neural oscillations in the γ-frequency band has been suggested
as a key mechanism underlying perceptual integration. In a recent
study, we found evidence for this hypothesis showing that the
modulation of interhemispheric oscillatory synchrony by means of
bihemispheric high-density transcranial alternating current stimulation
(HD-TACS) affects binaural integration of dichotic acoustic features.
Here, we aimed to establish a direct link between oscillatory
synchrony, effective brain connectivity, and binaural integration.
We experimentally manipulated oscillatory synchrony (using bihemispheric
γ-TACS with different interhemispheric phase lags) and
assessed the effect on effective brain connectivity and binaural integration
(as measured with functional MRI and a dichotic listening
task, respectively). We found that TACS reduced intrahemispheric
connectivity within the auditory cortices and antiphase (interhemispheric
phase lag 180°) TACS modulated connectivity between the
two auditory cortices. Importantly, the changes in intra- and interhemispheric
connectivity induced by TACS were correlated with
changes in perceptual integration. Our results indicate that γ-band
synchronization between the two auditory cortices plays a functional
role in binaural integration, supporting the proposed role
of interregional oscillatory synchrony in perceptual integration.

Abstract

This study investigates the effectiveness of training preschoolers in order to enhance their social cognition and pragmatic skills. Eighty-three 3–4-year-olds were divided into three groups and listened to stories enriched with mental state terms. Then, whereas the control group engaged in non-reflective activities, the two experimental groups were guided by a trainer to reflect on mental states depicted in the stories. In one of these groups, the children were prompted to not only talk about these states but also “embody” them through prosodic and gestural cues. Results showed that while there were no significant effects on Theory of Mind, emotion understanding, and mental state verb comprehension, the experimental groups significantly improved their pragmatic skill scores pretest-to-posttest. These results suggest that interactional interventions can contribute to preschoolers’ pragmatic development, demonstrate the value of the new embodied training, and highlight the importance of multidimensional testing for the evaluation of intervention effects.

Abstract

Whether neural networks can capture relational knowledge is a matter of long-standing controversy. Recently, some researchers have argued that (1) classic connectionist models can handle relational structure and (2) the success of deep learning approaches to natural language processing suggests that structured representations are unnecessary to model human language. We tested the Story Gestalt model, a classic connectionist model of text comprehension, and a Sequence-to-Sequence with Attention model, a modern deep learning architecture for natural language processing. Both models were trained to answer questions about stories based on abstract thematic roles. Two simulations varied the statistical structure of new stories while keeping their relational structure intact. The performance of each model fell below chance at least under one manipulation. We argue that both models fail our tests because they can't perform dynamic binding. These results cast doubts on the suitability of traditional neural networks for explaining relational reasoning and language processing phenomena.

Abstract

Recordings captured by wearable microphones are a standard method for investigating young children’s language environments. A key measure to quantify from such data is the amount of speech present in children’s home environments. To this end, the LENA recorder and software—a popular system for measuring linguistic input—estimates the number of adult words that children may hear over the course of a recording. However, word count estimation is challenging to do in a language-independent manner; the relationship between observable acoustic patterns and language-specific lexical entities is far from uniform across human languages. In this paper, we ask whether some alternative linguistic units, namely phone(me)s or syllables, could be measured instead of, or in parallel with, words in order to achieve improved cross-linguistic applicability and comparability of an automated system for measuring child language input. We discuss the advantages and disadvantages of measuring different units from theoretical and technical points of view. We also investigate the practical applicability of measuring such units using a novel system called Automatic LInguistic unit Count Estimator (ALICE) together with audio from seven child-centered daylong audio corpora from diverse cultural and linguistic environments. We show that language-independent measurement of phoneme counts is somewhat more accurate than syllables or words, but all three are highly correlated with human annotations on the same data. We share an open-source implementation of ALICE for use by the language research community, allowing automatic phoneme, syllable, and word count estimation from child-centered audio recordings.

Abstract

A cross-species perspective can extend and provide testable predictions for Savage et al.’s
framework. Rhythm and melody, I argue, could bootstrap each other in the evolution of
musicality. Isochrony may function as a temporal grid to support rehearsing and learning
modulated, pitched vocalizations. Once this melodic plasticity is acquired, focus can shift back to refining rhythm processing and beat induction.

Abstract

How music and speech evolved is a mystery. Several hypotheses on their
origins, including one on their joint origins, have been put forward but rarely
tested. Here we report and comment on the first experiment testing the hypothesis
that speech and music bifurcated from a common system. We highlight strengths
of the reported experiment, point out its relatedness to animal work, and suggest
three alternative interpretations of its results. We conclude by sketching a future
empirical programme extending this work.

Abstract

Cross-linguistic differences in morphological complexity could have important consequences for language learning. Specifically, it is often assumed that languages with more regular, compositional, and transparent grammars are easier to learn by both children and adults. Moreover, it has been shown that such grammars are more likely to evolve in bigger communities. Together, this suggests that some languages are acquired faster than others, and that this advantage can be traced back to community size and to the degree of systematicity in the language. However, the causal relationship between systematic linguistic structure and language learnability has not been formally tested, despite its potential importance for theories on language evolution, second language learning, and the origin of linguistic diversity. In this pre-registered study, we experimentally tested the effects of community size and systematic structure on adult language learning. We compared the acquisition of different yet comparable artificial languages that were created by big or small groups in a previous communication experiment, which varied in their degree of systematic linguistic structure. We asked (a) whether more structured languages were easier to learn; and (b) whether languages created by the bigger groups were easier to learn. We found that highly systematic languages were learned faster and more accurately by adults, but that the relationship between language learnability and linguistic structure was typically non-linear: high systematicity was advantageous for learning, but learners did not benefit from partly or semi-structured languages. Community size did not affect learnability: languages that evolved in big and small groups were equally learnable, and there was no additional advantage for languages created by bigger groups beyond their degree of systematic structure. Furthermore, our results suggested that predictability is an important advantage of systematic structure: participants who learned more structured languages were better at generalizing these languages to new, unfamiliar meanings, and different participants who learned the same more structured languages were more likely to produce similar labels. That is, systematic structure may allow speakers to converge effortlessly, such that strangers can immediately understand each other.

Abstract

Across multiple situations, child and adult learners are sensitive to co-occurrences between individual words and their referents in the environment, which provide a means by which the ambiguity of word-world mappings may be resolved (Monaghan & Mattock, 2012; Scott & Fisher, 2012; Smith & Yu, 2008; Yu & Smith, 2007). In three studies, we tested whether cross-situational learning is sufficiently powerful to support simultaneous learning the referents for words from multiple grammatical categories, a more realistic reflection of more complex natural language learning situations. In Experiment 1, adult learners heard sentences comprising nouns, verbs, adjectives, and grammatical markers indicating subject and object roles, and viewed a dynamic scene to which the sentence referred. In Experiments 2 and 3, we further increased the uncertainty of the referents by presenting two scenes alongside each sentence. In all studies, we found that cross-situational statistical learning was sufficiently powerful to facilitate acquisition of both vocabulary and grammar from complex sentence-to-scene correspondences, simulating the situations that more closely resemble the challenge facing the language learner.

Abstract

Two experiments tested whether the Dutch possessive pronoun zijn ‘his’ gives rise to a gender inference and thus causes a male bias when used generically in sentences such as Everyone was putting on his shoes. Experiment 1 (N = 120, 48 male) was a conceptual replication of a previous eye-tracking study that had not found evidence of a male bias. The results of the current eye-tracking experiment showed the generically-intended masculine pronoun to trigger a gender inference and cause a male bias, but for male participants and in stereotypically neutral stereotype contexts only. No evidence for a male bias was thus found in stereotypically female and male context nor for female participants altogether. Experiment 2 (N = 80, 40 male) used the same stimuli as Experiment 1, but employed the sentence evaluation paradigm. No evidence of a male bias was found in Experiment 2. Taken together, the results suggest that the generically-intended masculine pronoun zijn ‘his’ can cause a male bias for male participants even when the referents are previously introduced by inclusive and grammatically gender-unmarked iedereen ‘everyone’. This male bias surfaces with eye-tracking, which taps directly into early language processing, but not in offline sentence evaluations. Furthermore, the results suggest that the intended generic reading of the masculine possessive pronoun zijn ‘his’ is more readily available for women than for men.

Abstract

In the Romance languages, definite plural articles (e.g., le rane ‘the frogs’) are generally ambiguous between a generic and a specific interpretation, and speakers must reconstruct the intended interpretation through the linguistic or extra-linguistic context. Following the “polar bear” paradigm implemented in Czypionka & Kupisch (2019)’s investigation on German, the goal of the present study is to check the suitability of their test on article semantics, by establishing to what extent native speakers of Italian interpret ambiguous definite plural DPs as generic or specific in the presence of a nonlinguistic picture context. We present judgment and reaction time data monitoring the preferred reading of sentences introduced by different kinds of noun phrases (e.g., Le rane/Queste rane/Le rane di solito sono verdi/gialle ‘The/These/Usually frogs are green/yellow’), while looking at pictures showing prototypical or non-prototypical properties (e.g., green vs. yellow frogs). Our results show that both possible interpretations of definite plural articles are routinely considered in Italian, despite the presence of a picture with specific referents, validating the “polar bear” paradigm as a suitable test of article semantics.

Abstract

Negation in a number of Austronesian and Papuan languages with SVO order is expressed by a rather rigid clause-final position of the negative adverb. Some typological generalizations for negation are reviewed and the distribution of this trait in languages of different stocks is discussed, arguing that it most likely originates in Papuan languages. Some proposals for different types of negation, such as whether it is a verbal (or VP) operator, a constituent operator or a sentential operator are considered. The problem of determining the scope of negation is discussed, with the conclusion that hard and fast semantic meanings for NEG at different structural levels cannot be posited, suggesting that perhaps a solution can be found in the application of some universal pragmatic principles.

Abstract

Lexical-processing declines are a hallmark of aging. However, the extent of these declines may vary as a function of different factors. Motivated by findings from neurodegenerative diseases and healthy aging, we tested whether ‘motor-relatedness’ (the degree to which words are associated with particular human body movements) might moderate such declines. We investigated this question by examining data from three experiments. The experiments were carried out in different languages (Dutch, German, English) using different tasks (lexical decision, picture naming), and probed verbs and nouns, in all cases controlling for potentially confounding variables (e.g., frequency, age-of-acquisition, imageability). Whereas ‘non-motor words’ (e.g., steak) showed age-related performance decreases in all three experiments, ‘motor words’ (e.g., knife) yielded either smaller decreases (in one experiment) or no decreases (in two experiments). The findings suggest that motor-relatedness can attenuate or even prevent age-related lexical declines, perhaps due to the relative sparing of neural circuitry underlying such words.

Abstract

This review paper discusses rhythmic dyadic interactions in social and sexual contexts. We report rhythmic interactions during communication within dyads, as found in humans, non-human primates, non-primate mammals, birds, anurans and insects. Based on the patterns observed, we infer adaptive explanations for the observed rhythm interactions and identify knowledge gaps. Across species, the social environment during ontogeny is a key factor in shaping adult signal repertoires and timing mechanisms used to regulate interactions. The degree of temporal coordination is influenced by the dynamic and strength of the dyadic interaction. Most studies of temporal structure in interactive signals mainly focus on one modality (acoustic and visual); we suggest more work should be performed on multimodal signals. Multidisciplinary approaches combining cognitive science, ethology and ecology should shed more light on the exact timing mechanisms involved. Taken together, rhythmic signalling behaviours are widespread and critical in regulating social interactions across taxa.

Abstract

High-quality and complete reference genome assemblies are fundamental for the application of genomics to biology, disease, and biodiversity conservation. However, such assemblies are available for only a few non-microbial species1,2,3,4. To address this issue, the international Genome 10K (G10K) consortium5,6 has worked over a five-year period to evaluate and develop cost-effective methods for assembling highly accurate and nearly complete reference genomes. Here we present lessons learned from generating assemblies for 16 species that represent six major vertebrate lineages. We confirm that long-read sequencing technologies are essential for maximizing genome quality, and that unresolved complex repeats and haplotype heterozygosity are major sources of assembly error when not handled correctly. Our assemblies correct substantial errors, add missing sequence in some of the best historical reference genomes, and reveal biological discoveries. These include the identification of many false gene duplications, increases in gene sizes, chromosome rearrangements that are specific to lineages, a repeated independent chromosome breakpoint in bat genomes, and a canonical GC-rich pattern in protein-coding genes and their regulatory regions. Adopting these lessons, we have embarked on the Vertebrate Genomes Project (VGP), an international effort to generate high-quality, complete reference genomes for all of the roughly 70,000 extant vertebrate species and to help to enable a new era of discovery across the life sciences.

Abstract

Examines the basic constituent order (BCO) on the transitive sentences in the Tenejapa dialect of Tzeltal. Concept of the basic word order; Patterns of constituent order of the transitive clauses; Consideration of VOA as the BCO.

Abstract

Despite advances in automatic speech recognition (ASR), human input is still essential to produce research-grade segmentations of speech data. Con- ventional approaches to manual segmentation are very labour-intensive. We introduce POnSS, a browser-based system that is specialized for the task of segmenting the onsets and offsets of words, that combines aspects of ASR with limited human input. In developing POnSS, we identified several sub- tasks of segmentation, and implemented each of these as separate interfaces for the annotators to interact with, to streamline their task as much as possible. We evaluated segmentations made with POnSS against a base- line of segmentations of the same data made conventionally in Praat. We observed that POnSS achieved comparable reliability to segmentation us- ing Praat, but required 23% less annotator time investment. Because of its greater efficiency without sacrificing reliability, POnSS represents a distinct methodological advance for the segmentation of speech data.

Abstract

Santiago, MacKay, Palma, and Rho (2000) report two picture naming experiments examining the role of syllable onset complexity and number of syllables in spoken word production. Experiment 1 showed that naming latencies are longer for words with two syllables (e.g., demon ) than one syllable (e.g., duck ), and longer for words beginning with a consonant cluster (e.g., drill ) than a single consonant (e.g., duck ). Experiment 2 replicated these findings and showed that the complexity of the syllable nucleus and coda has no effect. These results are taken to support MacKay's (1987) Node Structure theory and to refute models such as WEAVER++ (Roelofs, 1997a) that predict effects of word length but not of onset complexity and number of syllables per se. In this comment, I show that a re-analysis of the data of Santiago et al. that takes word length into account leads to the opposite conclusion. The observed effects of onset complexity and number of syllables appear to be length effects, supporting WEAVER++ and contradicting the Node Structure theory.

Abstract

Minimalist theories of spoken language planning hold that articulation starts when the first
speech segment has been planned, whereas non-minimalist theories assume larger units (e.g.,
Levelt, Roelofs, & Meyer, 1999a). Three experiments are reported, which were designed to distinguish
between these views using a newhybrid task that factorially manipulated preparation and
auditory priming of spoken language production. Minimalist theories predict no effect from
priming of non-initial segments when the initial segment of an utterance is already prepared;
observing such a priming effect would support non-minimalist theories. In all three experiments,
preparation and priming yielded main effects, and together their effects were additive. Preparation
of initial segments does not eliminate priming effects for later segments. These results challenge
the minimalist view. The findings are simulated by WEAVER++ (Roelofs, 1997b), which
employs the phonological word as the lower limit for articulation initiation.

Abstract

The control of language use has in its simplest form perhaps been most intensively studied using the color–word Stroop task. The authors review chronometric and neuroimaging evidence on Stroop task performance to evaluate two prominent, implemented models of control in naming and reading: GRAIN and WEAVER++. Computer simulations are reported, which reveal that WEAVER++ offers a more satisfactory account of the data than GRAIN. In particular, we report WEAVER++ simulations of the BOLD response in anterior cingulate cortex during Stroop performance. Aspects of single-word production and perception in the Stroop task are discussed in relation to the wider problem of the control of language use.

Abstract

The authors report a study in Dutch that used an on-line preparation paradigm to test the issue of semantic
dependency versus morphological autonomy in the production of polymorphemic words. Semantically
transparent complex words (like input in English) and semantically opaque complex words
(like invoice) showed clear evidence of morphological structure in word-form encoding, since both exhibited
an equally large preparation effect that was much greater than that for morphologically simple
words (like insect). These results suggest that morphemes may be planning units in the production of
complex words, without making a semantic contribution, thereby supporting the autonomy view. Language
production establishes itself as a domain in which morphology may operate “by itself” (Aronoff,
1994) without recourse to meaning.

Abstract

Conversation analysis (CA) is an approach to the study of language and social interaction that puts at center stage its sequential development. The chain of initiating and responding actions that characterizes any interaction is a source of internal evidence for the meaning of social behavior as it exposes the understandings that participants themselves give of what one another is doing. Such an analysis requires the close and repeated inspection of audio and video recordings of naturally occurring interaction, supported by transcripts and other forms of annotation. Distributional regularities are complemented by a demonstration of participants' orientation to deviant behavior. CA has long maintained a constructive dialogue and reciprocal influence with linguistic anthropology. This includes a recent convergence on the cross-linguistic and cross-cultural study of social interaction.

Abstract

This article is concerned with how social categories (e.g., wife, mother, sister, tenant, guest) become visible through the actions that individuals perform in social interaction. Using audio and video recordings of social interaction as data and conversation analysis as a method, we examine how individuals display their rights or constraints to perform certain actions by virtue of occupying a certain social category. We refer to actions whose performance is sensitive to membership in a certain social category as category-sensitive actions. Most of the time, the social boundaries surrounding these actions remain invisible because participants in interaction typically act in ways that are consistent with their social status and roles. In this study, however, we specifically examine instances where category boundaries become visible as participants approach, expose, or transgress them. Our focus is on actions with relatively stringent category sensitivity such as requests, offers, invitations, or handling one’s possessions. Ultimately, we believe these are the tip of an iceberg that potentially includes most, if not all, actions.

Abstract

Clinical neuroscience research relying on animal models brought valuable translational insights into the function and pathologies of the human brain. The anatomical, physiological, and behavioural similarities between humans and mammals have prompted researchers to study cerebral mechanisms at different levels to develop and test new treatments. The vast majority of biomedical research uses rodent models, which are easily manipulable and have a broadly resembling organisation to the human nervous system but cannot satisfactorily mimic some disorders. For these disorders, macaque monkeys have been used as they have a more comparable central nervous system. Still, this research has been hampered by limitations, including high costs and reduced samples. This review argues that a squirrel monkey model might bridge the gap by complementing translational research from rodents, macaque, and humans. With the advent of promising new methods such as ultrasound imaging, tool miniaturisation, and a shift towards open science, the squirrel monkey model represents a window of opportunity that will potentially fuel new translational discoveries in the diagnosis and treatment of brain pathologies.

Abstract

A psychophysical analysis of referential communication establishes a causal link between a visual stimulus and a speaker’s perception of this stimulus, and between the speaker’s internal representation and their reference production. Here, I argue that, in addition to visual perception and language, social cognition plays an integral part in this complex process, as it enables successful speaker-listener coordination. This pragmatic analysis of referential communication tries to explain the redundant use of color adjectives. It is well documented that people use color words when it is not necessary to identify the referent; for instance, they may refer to “the blue star” in a display of shapes with a single star. This type of redundancy challenges influential work from cognitive science and philosophy of language, suggesting that human communication is fundamentally efficient. Here, I explain these seemingly contradictory findings by confirming the visual efficiency hypothesis: redundant color words can facilitate the listener’s visual search for a referent, despite making the description unnecessarily long. Participants’ eye movements revealed that they were faster to find “the blue star” than “the star” in a display of shapes with only one star. A language production experiment further revealed that speakers are highly sensitive to a target’s discriminability, systematically reducing their use of redundant color adjectives as the color of the target became more pervasive in a display. It is concluded that a referential expression’s efficiency should be based not only on its informational value, but also on its discriminatory value, which means that redundant color words can be more efficient than shorter descriptions.

Abstract

Pragmatic theories and computational models of reference must account for people’s frequent use of redundant color adjectives (e.g., referring to a single triangle as “the blue triangle”). The standard pragmatic view holds that the informativity of a referential expression depends on pragmatic contrast: Color adjectives should be used to contrast competitors of the same kind to preempt an ambiguity (e.g., between several triangles of different colors), otherwise they are redundant. Here we propose an alternative to the standard view, the incremental efficiency hypothesis, according to which the efficiency of a referential expression must be calculated incrementally over the entire visual context. This is the first theoretical account of referential efficiency that is sensitive to the incrementality of language processing, making different cross-linguistic predictions depending on word order. Experiment 1 confirmed that English speakers produced more redundant color adjectives (e.g., “the blue triangle”) than Spanish speakers (e.g., “el triángulo azul”), but both language groups used more redundant color adjectives in denser displays where it would be more efficient. In Experiments 2A and 2B, we used eye tracking to show that pragmatic contrast is not a processing constraint. Instead, incrementality and efficiency determine that English listeners establish color contrast across categories (BLUE SHAPES > TRIANGULAR ONE), whereas Spanish listeners establish color contrast within a category (TRIANGLES > BLUE ONE). Spanish listeners, however, reversed their visual search strategy when tested in English immediately after. Our results show that speakers and listeners of different languages exploit word order to increase communicative efficiency.

Abstract

Language and Theory of Mind come together in communication, but their relationship has been intensely contested. I hypothesize that pragmatic markers connect language and Theory of Mind and enable their co-development and co-evolution through a positive feedback loop, whereby the development of one skill boosts the development of the other. I propose to test this hypothesis by investigating two types of pragmatic markers: demonstratives (e.g., ‘this’ vs. ‘that’ in English) and articles (e.g., ‘a’ vs. ‘the’). Pragmatic markers are closed-class words that encode non-representational information that is unavailable to consciousness, but accessed automatically in processing. These markers have been associated with implicit Theory of Mind because they are used to establish joint attention (e.g., ‘I prefer that one’) and mark shared knowledge (e.g., ‘We bought the house’ vs. ‘We bought a house’). Here I develop a theoretical account of how joint attention (as driven by the use of demonstratives) is the basis for children’s later tracking of common ground (as marked by definite articles). The developmental path from joint attention to common ground parallels language change, with demonstrative forms giving rise to definite articles. This parallel opens the possibility of modelling the emergence of Theory of Mind in human development in tandem with its routinization across language communities and generations of speakers. I therefore propose that, in order to understand the relationship between language and Theory of Mind, we should study pragmatics at three parallel timescales: during language acquisition, language use, and language change.

Abstract

The nature of phonological representations has been extensively studied in phonology and psycholinguistics. While full specification is still the norm in psycholinguistic research, underspecified representations may better account for perceptual asymmetries. In this paper, we report on a mismatch negativity (MMN) study with Dutch listeners who took part in a passive oddball paradigm to investigate when the brain notices the difference between expected and observed vowels. In particular, we tested neural discrimination (indicating perceptual discrimination) of the tense mid vowel pairs /o/-/ø/ (place contrast), /e/-/ø/ (labiality or rounding contrast), and /e/-/o/ (place and labiality contrast). Our results show (a) a perceptual asymmetry for place in the /o/-/ø/ contrast, supporting underspecification of [CORONAL] and replicating earlier results for German, and (b) a perceptual asymmetry for labiality for the /e/-/ø/ contrast, which was not reported in the German study. A labial deviant [ø] (standard /e/) yielded a larger MMN than a deviant [e] (standard /ø/). No asymmetry was found for the two-feature contrast. This study partly replicates a similar MMN study on German vowels, and partly presents new findings indicating cross-linguistic differences. Although the vowel inventory of Dutch and German is to a large extent comparable, their (morpho)phonological systems are different, which is reflected in processing.

Abstract

Pervading global narratives suggest that political polarization is increasing, yet the accuracy of such group meta-perceptions has been drawn into question. A recent US study suggests that these beliefs are inaccurate and drive polarized beliefs about out-groups. However, it also found that informing people of inaccuracies reduces those negative beliefs. In this work, we explore whether these results generalize to other countries. To achieve this, we replicate two of the original experiments with 10,207 participants across 26 countries. We focus on local group divisions, which we refer to as fault lines. We find broad generalizability for both inaccurate meta-perceptions and reduced negative motive attribution through a simple disclosure intervention. We conclude that inaccurate and negative group meta-perceptions are exhibited in myriad contexts and that informing individuals of their misperceptions can yield positive benefits for intergroup relations. Such generalizability highlights a robust phenomenon with implications for political discourse worldwide.

Abstract

We analysed both structural and functional aspects of sentences containing the four
adverbials “after”, “before”, “because”, and “if” in two dense corpora of parent-child
interactions from two British English-acquiring children (2;00–4;07). In comparing
mothers’ and children’s usage we separate out the effects of frequency, cognitive
complexity and pragmatics in explaining the course of acquisition of adverbial
sentences. We also compare these usage patterns to stimuli used in a range of
experimental studies and show how differences may account for some of the difficulties
that children have shown in experiments. In addition, we report descriptive data on
various aspects of adverbial sentences that have not yet been studied as a resource for
future investigations.

Abstract

In recent years, it has become clear that attention plays an important role in spoken word production. Some of this evidence comes from distributional analyses of reaction time (RT) in regular picture naming and picture-word interference. Yet we lack a mechanistic account of how the properties of RT distributions come to reflect attentional processes and how these processes may in turn modulate the amount of conflict between lexical representations. Here, we present a computational account according to which attentional lapses allow for existing conflict to build up unsupervised on a subset of trials, thus modulating the shape of the resulting RT distribution. Our process model resolves discrepancies between outcomes of previous studies on semantic interference. Moreover, the model's predictions were confirmed in a new experiment where participants' motivation to remain attentive determined the size and distributional locus of semantic interference in picture naming. We conclude that process modeling of RT distributions importantly improves our understanding of the interplay between attention and conflict in word production. Our model thus provides a framework for interpreting distributional analyses of RT data in picture naming tasks.

Abstract

A realtime online learning system with capacity limits needs to gradually forget old information in order to avoid catastrophic forgetting. This can be achieved by allowing new information to overwrite old, as in a so-called palimpsest memory. This paper describes an incremental learning rule based on the Bayesian confidence propagation neural network that has palimpsest properties when employed in an attractor neural network. The network does not suffer from catastrophic forgetting, has a capacity dependent on the learning time constant and exhibits faster convergence for newer patterns.

Abstract

Memory is fundamental for comprehending and segmenting the flow of activity around us into units called “events”. Here, we investigate the effect of the movement dynamics of actions (ceased, ongoing) and the inner structure of events (with or without object-state change) on people's event memory. Furthermore, we investigate how describing events, and the meaning and form of verb predicates used (denoting a culmination moment, or not, in single verbs or verb-satellite constructions), affects event memory. Before taking a surprise recognition task, Spanish and Mandarin speakers (who lexicalise culmination in different verb predicate forms) watched short videos of events, either in a non-verbal (probe-recognition) or a verbal experiment (event description). Results show that culminated events (i.e. ceased change-of-state events) were remembered best across experiments. Language use showed to enhance memory overall. Further, the form of the verb predicates used for denoting culmination had a moderate effect on memory.

Abstract

Human experience and communication are centred on events, and event apprehension is a rapid process that draws on the visual perception and immediate categorization of event roles (“who does what to whom”). We demonstrate a role for syntactic structure in visual information uptake for event apprehension. An event structure foregrounding either the agent or patient was activated during speaking, transiently modulating the apprehension of subsequently viewed unrelated events. Speakers of Dutch described pictures with actives and passives (agent and patient foregrounding, respectively). First fixations on pictures of unrelated events that were briefly presented (for 300 ms) next were influenced by the active or passive structure of the previously produced sentence. Going beyond the study of how single words cue object perception, we show that sentence structure guides the viewpoint taken during rapid event apprehension.

Abstract

Background

Heterozygous variants in CNTNAP2 have been implicated in a wide range of neurological phenotypes, including intellectual disability (ID), epilepsy, autistic spectrum disorder (ASD), and impaired language. However, heterozygous variants can also be found in unaffected individuals. Biallelic CNTNAP2 variants are rarer and cause a well-defined genetic syndrome known as CASPR2 deficiency disorder, a condition characterised by ID, early-onset refractory epilepsy, language impairment, and autistic features.
Case-report

A 7-year-old boy presented with hyperkinetic stereotyped movements that started during early infancy and persisted over childhood. Abnormal movements consisted of rhythmic and repetitive shaking of the four limbs, with evident stereotypic features. Additional clinical features included ID, attention deficit-hyperactivity disorder (ADHD), ASD, and speech impairment, consistent with CASPR2 deficiency disorder. Whole-genome array comparative genomic hybridization detected a maternally inherited 0.402 Mb duplication, which involved intron 1, exon 2, and intron 2 of CNTNAP2 (c.97 +?_209-?dup). The affected region in intron 1 contains a binding site for the transcription factor FOXP2, potentially leading to abnormal CNTNAP2 expression regulation. Sanger sequencing of the coding region of CNTNAP2 also identified a paternally-inherited missense variant c.2752C > T, p.(Leu918Phe).
Conclusion

This case expands the molecular and phenotypic spectrum of CASPR2 deficiency disorder, suggesting that Hyperkinetic stereotyped movements may be a rare, yet significant, clinical feature of this complex neurological disorder. Furthermore, the identification of an in-frame, largely non-coding duplication in CNTNAP2 points to a sophisticated underlying molecular mechanism, likely involving impaired FOXP2 binding.

Abstract

The evaluation of transcranial magnetic stimulation (TMS)-induced motor evoked potentials (MEPs) promises valuable information about fundamental brain related mechanisms and may serve as a diagnostic tool for clinical monitoring of therapeutic progress or surgery procedures. However, reports about spontaneous fluctuations of MEP amplitudes causing high intra-individual variability have led to increased concerns about the reliability of this measure. One possible cause for high variability of MEPs could be neuronal oscillatory activity, which reflects fluctuations of membrane potentials that systematically increase and decrease the excitability of neuronal networks. Here, we investigate the dependence of MEP amplitude on oscillation power and phase by combining the application of single pulse TMS over the primary motor cortex with concurrent recordings of electromyography and electroencephalography. Our results show that MEP amplitude is correlated to alpha phase, alpha power as well as beta phase. These findings may help explain corticospinal excitability fluctuations by highlighting the modulatory effect of alpha and beta phase on MEPs. In the future, controlling for such a causal relationship may allow for the development of new protocols, improve this method as a (diagnostic) tool and increase the specificity and efficacy of general TMS applications.

Abstract

Two experiments investigate the effect of number congruency using picture–word interference. Native German participants were required to name pictures of single objects (Nase ‘nose’) or two instances of the same object (Nasen ‘noses’) while ignoring simultaneously presented distractor words. Distractor words either had the same number or were different in number. In addition, the type of plural formation (same or different inflectional plural suffix) and the semantic relationship (same or different semantic category) between target and distractor were varied in Experiments 1 and 2. Results showed no effect of number congruency in either experiment. Furthermore, the type of inflectional suffix did not exert an influence on naming latencies in Experiment 1, but semantic relationship led to a significant interference effect in Experiment 2. The results indicate that selection of the number feature diacritic in noun production is not a competitive process. The implications of the results for models of lexical access are discussed.

Abstract

In certain varieties of Dutch spoken among young people, the preposition and determiner in locative and directional PPs can sometimes be omitted. We argue on the basis of language data taken from Twitter and intuitions of young speakers of Dutch that nominal arguments in these constructions do not have a DP layer, the absence of which leads to a special interpretation. The option to omit the preposition is related to the structural and semantic complexity of the verb. The bare construction is possible only with simple verbs, and not with manner-of-motion verbs. We present an analysis that accounts for the non-pronunciation of prepositions in directional predicates by claiming that they can be licensed through incorporation into the verb. This type of incorporation is blocked if the verb is structurally complex.

Abstract

When comprehending speech-in-noise (SiN), younger and older adults benefit from seeing the speaker’s mouth, i.e. visible speech. Younger adults additionally benefit from manual iconic co-speech gestures. Here, we investigate to what extent younger and older adults benefit from perceiving both visual articulators while comprehending SiN, and whether this is modulated by working memory and inhibitory control. Twenty-eight younger and 28 older adults performed a word recognition task in three visual contexts: mouth blurred (speech-only), visible speech, or visible speech + iconic gesture. The speech signal was either clear or embedded in multitalker babble. Additionally, there were two visual-only conditions (visible speech, visible speech + gesture). Accuracy levels for both age groups were higher when both visual articulators were present compared to either one or none. However, older adults received a significantly smaller benefit than younger adults, although they performed equally well in speech-only and visual-only word recognition. Individual differences in verbal working memory and inhibitory control partly accounted for age-related performance differences. To conclude, perceiving iconic gestures in addition to visible speech improves younger and older adults’ comprehension of SiN. Yet, the ability to benefit from this additional visual information is modulated by age and verbal working memory. Future research will have to show whether these findings extend beyond the single word level.

Abstract

Although feedforward activity may suffice for recognizing objects in isolation, additional visual operations that aid object recognition might be needed for real-world scenes. One such additional operation is figure-ground segmentation, extracting the relevant features and locations of the target object while ignoring irrelevant features. In this study of 60 human participants (female and male), we show objects on backgrounds of increasing complexity to investigate whether recurrent computations are increasingly important for segmenting objects from more complex backgrounds. Three lines of evidence show that recurrent processing is critical for recognition of objects embedded in complex scenes. First, behavioral results indicated a greater reduction in performance after masking objects presented on more complex backgrounds, with the degree of impairment increasing with increasing background complexity. Second, electroencephalography (EEG) measurements showed clear differences in the evoked response potentials between conditions around time points beyond feedforward activity, and exploratory object decoding analyses based on the EEG signal indicated later decoding onsets for objects embedded in more complex backgrounds. Third, deep convolutional neural network performance confirmed this interpretation. Feedforward and less deep networks showed a higher degree of impairment in recognition for objects in complex backgrounds compared with recurrent and deeper networks. Together, these results support the notion that recurrent computations drive figure-ground segmentation of objects in complex scenes.SIGNIFICANCE STATEMENT The incredible speed of object recognition suggests that it relies purely on a fast feedforward buildup of perceptual activity. However, this view is contradicted by studies showing that disruption of recurrent processing leads to decreased object recognition performance. Here, we resolve this issue by showing that how object recognition is resolved and whether recurrent processing is crucial depends on the context in which it is presented. For objects presented in isolation or in simple environments, feedforward activity could be sufficient for successful object recognition. However, when the environment is more complex, additional processing seems necessary to select the elements that belong to the object and by that segregate them from the background.

Abstract

Object and scene recognition both require mapping of incoming sensory information to existing conceptual knowledge about the world. A notable finding in brain-damaged patients is that they may show differentially impaired performance for specific categories, such as for “living exemplars”. While numerous patients with category-specific impairments have been reported, the explanations for these deficits remain controversial. In the current study, we investigate the ability of a brain injured patient with a well-established category-specific impairment of semantic memory to perform two categorization experiments: ‘natural’ vs. ‘manmade’ scenes (experiment 1) and objects (experiment 2). Our findings show that the pattern of categorical impairment does not respect the natural versus manmade distinction. This suggests that the impairments may be better explained by differences in visual features, rather than by category membership. Using Deep Convolutional Neural Networks (DCNNs) as ‘artificial animal models’ we further explored this idea. Results indicated that DCNNs with ‘lesions’ in higher order layers showed similar response patterns, with decreased relative performance for manmade scenes (experiment 1) and natural objects (experiment 2), even though they have no semantic category knowledge, apart from a mapping between pictures and labels. Collectively, these results suggest that the direction of category-effects to a large extent depends, at least in MS′ case, on the degree of perceptual differentiation called for, and not semantic knowledge.

Abstract

Contrary to received opinion, the Aristotelian Square of Opposition (square) is logically sound, differing from standard modern predicate logic (SMPL) only in that it restricts the universe U of cognitively constructible situations by banning null predicates, making it less unnatural than SMPL. U-restriction strengthens the logic without making it unsound. It also invites a cognitive approach to logic. Humans are endowed with a cognitive predicate logic (CPL), which checks the process of cognitive modelling (world construal) for consistency. The square is considered a first approximation to CPL, with a cognitive set-theoretic semantics. Not being cognitively real, the null set Ø is eliminated from the semantics of CPL. Still rudimentary in Aristotle’s On Interpretation (Int), the square was implicitly completed in his Prior Analytics (PrAn), thereby introducing U-restriction. Abelard’s reconstruction of the logic of Int is logically and historically correct; the loca (Leaking O-Corner Analysis) interpretation of the square, defended by some modern logicians, is logically faulty and historically untenable. Generally, U-restriction, not redefining the universal quantifier, as in Abelard and loca, is the correct path to a reconstruction of CPL. Valuation Space modelling is used to compute the effects of U-restriction.

Abstract

Semantic Syntax (SeSyn), originally called Generative Semantics, is an offshoot of Chomskyan generative grammar (ChoGG), rejected by Chomsky and his school in the late 1960s. SeSyn is the theory of algorithmical grammars producing the well-formed sentences of a language L from the corresponding semantic input, the Semantic Analysis (SA), represented as a traditional tree structure diagram in a specific formal language of incremental predicate logic with quantifying and qualifying operators (including the truth functions), and with all lexical items filled in. A SeSyn-type grammar is thus by definition transformational, but not generative. The SA originates in cognition in a manner that is still largely mysterious, but its actual form can be distilled from the Surface Structure (SS) of the sentences of L following the principles set out in SeSyn. In this presentation we provide a more or less technical résumé of the SeSyn theory. A comparison is made with ChoGG-type grammars, which are rejected on account of their intrinsic unsuitability as a cognitive-realist grammar model. The ChoGG model follows the pattern of a 1930s neopositivist Carnap-type grammar for formal logical languages. Such grammars are random sentence generators, whereas, obviously, (nonpathological) humans are not. A ChoGG-type grammar is fundamentally irreconcilable with a mentalist-realist theory of grammar. The body of the paper consists in a demonstration of the production of an English and a French sentence, the latter containing a classic instance of the cyclic rule of Predicate Raising (PR), essential in the general theory of clausal complementation yet steadfastly repudiated in ChoGG for reasons that have never been clarified. The processes and categories defined in SeSyn are effortlessly recognised in languages all over the world, whether indigenous or languages of a dominant culture—taking into account language-specific values for the general theoretical parameters involved. This property makes SeSyn particularly relevant for linguistic typology, which now ranks as the most promising branch of linguistics but has so far conspicuously lacked an adequate theoretical basis.

Abstract

One of the challenges in speech perception is that listeners must deal with considerable
segmental and suprasegmental variability in the acoustic signal due to differences between talkers. Most previous studies have focused on how listeners deal with segmental variability.
In this EEG experiment, we investigated whether listeners track talker-specific usage of suprasegmental cues to lexical stress to recognize spoken words correctly. In a three-day training phase, Dutch participants learned to map non-word minimal stress pairs onto different object referents (e.g., USklot meant “lamp”; usKLOT meant “train”). These non-words were
produced by two male talkers. Critically, each talker used only one suprasegmental cue to signal stress (e.g., Talker A used only F0 and Talker B only intensity). We expected participants to learn which talker used which cue to signal stress. In the test phase, participants indicated whether spoken sentences including these non-words were correct (“The word for lamp is…”).
We found that participants were slower to indicate that a stimulus was correct if the non-word was produced with the unexpected cue (e.g., Talker A using intensity). That is, if in training Talker A used F0 to signal stress, participants experienced a mismatch between predicted and perceived phonological word-forms if, at test, Talker A unexpectedly used intensity to cue
stress. In contrast, the N200 amplitude, an event-related potential related to phonological
prediction, was not modulated by the cue mismatch. Theoretical implications of these
contrasting results are discussed. The behavioral findings illustrate talker-specific prediction of prosodic cues, picked up through perceptual learning during training.

Abstract

Autism spectrum disorder (ASD) and schizophrenia have been conceived as partly opposing disorders in terms of systemizing versus empathizing cognitive styles, with resemblances to male versus female average sex differences. Left-right asymmetry of the brain is an important aspect of its organization that shows average differences between the sexes, and can be altered in both ASD and schizophrenia. Here we mapped multivariate associations of polygenic risk scores for ASD and schizophrenia with asymmetries of regional cerebral cortical surface area, thickness and subcortical volume measures in 32,256 participants from the UK Biobank. Polygenic risks for the two disorders were positively correlated (r=0.08, p=7.13×10-50), and both were higher in females compared to males, consistent with biased participation against higher-risk males. Each polygenic risk score was associated with multivariate brain asymmetry after adjusting for sex, ASD r=0.03, p=2.17×10-9, schizophrenia r=0.04, p=2.61×10-11, but the multivariate patterns were mostly distinct for the two polygenic risks, and neither resembled average sex differences. Annotation based on meta-analyzed functional imaging data showed that both polygenic risks were associated with asymmetries of regions important for language and executive functions, consistent with behavioural associations that arose in phenome-wide association analysis. Overall, the results indicate that distinct patterns of subtly altered brain asymmetry may be functionally relevant manifestations of polygenic risks for ASD and schizophrenia, but do not support brain masculinization or feminization in their etiologies.

Abstract

Roughly 10% of the human population is left-handed, and this rate is increased in some brain-related disorders. The neuroanatomical correlates of hand preference have remained equivocal. We resampled structural brain image data from 28,802 right-handers and 3,062 left-handers (UK Biobank population dataset) to a symmetrical surface template, and mapped asymmetries for each of 8,681 vertices across the cerebral cortex in each individual. Left-handers compared to right-handers showed average differences of surface area asymmetry within the fusiform cortex, the anterior insula, the anterior middle cingulate cortex, and the precentral cortex. Meta-analyzed functional imaging data implicated these regions in executive functions and language. Polygenic disposition to left-handedness was associated with two of these regional asymmetries, and 18 loci previously linked with left-handedness by genome-wide screening showed associations with one or more of these asymmetries. Implicated genes included six encoding microtubule-related proteins: TUBB, TUBA1B, TUBB3, TUBB4A, MAP2, and NME7—mutations in the latter can cause left to right reversal of the visceral organs. There were also two cortical regions where average thickness asymmetry was altered in left-handedness: on the postcentral gyrus and the inferior occipital cortex, functionally annotated with hand sensorimotor and visual roles. These cortical thickness asymmetries were not heritable. Heritable surface area asymmetries of language-related regions may link the etiologies of hand preference and language, whereas nonheritable asymmetries of sensorimotor cortex may manifest as consequences of hand preference.

Abstract

Left–right hemispheric asymmetry is an important aspect of healthy brain organization for many functions including language, and it can be altered in cognitive and psychiatric disorders. No mechanism has yet been identified for establishing the human brain’s left–right axis. We performed multivariate genome-wide association scanning of cortical regional surface area and thickness asymmetries, and subcortical volume asymmetries, using data from 32,256 participants from the UK Biobank. There were 21 significant loci associated with different aspects of brain asymmetry, with functional enrichment involving microtubule-related genes and embryonic brain expression. These findings are consistent with a known role of the cytoskeleton in left–right axis determination in other organs of invertebrates and frogs. Genetic variants associated with brain asymmetry overlapped with those associated with autism, educational attainment and schizophrenia. Comparably large datasets will likely be required in future studies, to replicate and further clarify the associations of microtubule-related genes with variation in brain asymmetry, behavioural and psychiatric traits.

Abstract

Several abilities outside literacy proper are associated with reading and spelling, both phenotypically and genetically, though our knowledge of multivariate genomic covariance structures is incomplete. Here, we introduce structural models describing genetic and residual influences between traits to study multivariate links across measures of literacy, phonological awareness, oral language, and phonological working memory (PWM) in unrelated UK youth (8-13 years, N=6,453). We find that all phenotypes share a large proportion of underlying genetic variation, although especially oral language and PWM reveal substantial differences in their genetic variance composition with substantial trait-specific genetic influences. Multivariate genetic and residual trait covariance showed concordant patterns, except for marked differences between oral language and literacy/phonological awareness, where strong genetic links contrasted near-zero residual overlap. These findings suggest differences in etiological mechanisms, acting beyond a pleiotropic set of genetic variants, and implicate variation in trait modifiability even among phenotypes that have high genetic correlations.

Abstract

This article addresses the problem of computing an upper bound of
the degree d of a polynomial solution P(x) of an algebraic differ-
ence equation of the form Gx)(P(x −τ1), . . . , P(x −τs) + G0(x) =

0 when such P(x) with the coefficients in a field K of character-
istic zero exists and where G is a non-linear s-variable polynomial
with coefficients in K[x] and G0 is a polynomial with coefficients
in K.
It will be shown that if G is a quadratic polynomial with constant
coefficients then one can construct a countable family of polynomi-
als fl(u0) such that if there exists a (minimal) index l0 with fl0(u0)
being a non-zero polynomial, then the degree d is one of its roots
or d ≤ l0, or d < deg(G0). Moreover, the existence of such l0 will
be proven for K being the field of real numbers. These results are
based on the properties of the modules generated by special fami-
lies of homogeneous symmetric polynomials.
A sufficient condition for the existence of a similar bound of the
degree of a polynomial solution for an algebraic difference equation
with G of arbitrary total degree and with variable coefficients will
be proven as well.

Abstract

A doubly quantified sentence, such as All hikers climbed a hill, allows two interpretations: Did all hikers climb different hills, or did they climb the same hill? Previous work has shown that comprehenders construct disambiguated logical representations of these interpretations (Raffray & Pickering, 2010). We extended this line of research by investigating whether bilingual logical representations are shared between languages or separate per language. We conducted four sentence-picture matching experiments in which we primed interpretations of doubly quantified sentences in Dutch and French monolingual and bilingual language comprehension. These experiments showed that bilinguals have fully shared logical representations and that logical representations constructed in the L1 and the L2 are comparable. Moreover, a control experiment ruled out that the priming effects were driven by visual overlap between prime and target pictures. We discuss these findings in terms of a language-dependent account of logical representations, although these findings can also be reconciled with the idea that logical representations involve conceptual mental models of sentence meaning.

Abstract

Linguistic labels exert a particularly strong top-down influence on perception. The potency of this influence has been ascribed to their ability to evoke category-diagnostic features of concepts. In doing this, they facilitate the formation of a perceptual template concordant with those features, effectively biasing perceptual activation towards the labelled category. In this study, we employ a cueing paradigm with moving, point-light stimuli across three experiments, in order to examine how the number of biological motion features (form and kinematics) encoded in lexical cues modulates the efficacy of lexical top-down influence on perception. We find that the magnitude of lexical influence on biological motion perception rises as a function of the number of biological motion-relevant features carried by both cue and target. When lexical cues encode multiple biological motion features, this influence is robust enough to mislead participants into reporting erroneous percepts, even when a masking level yielding high performance is used.

Abstract

Meanings communicated with depictions constitute an integral part of how speakers and signers actually use language (Clark, 2016). Recent studies have argued that, in sign languages, depicting strategy like constructed action (CA), in which a signer enacts the referent, is used for referential purposes in narratives. Here, we tested the referential function of CA in a more controlled experimental setting and outside narrative context. Given the iconic properties of CA we hypothesized that this strategy could be used for efficient information transmission. Thus, we asked if use of CA increased with the increase in the information required to be communicated. Twenty-three deaf signers of LIS described unconnected images, which varied in the amount of information represented, to another player in a director–matcher game. Results revealed that participants used CA to communicate core information about the images and also increased the use of CA as images became informatively denser. The findings show that iconic features of CA can be used for referential function in addition to its depictive function outside narrative context and to achieve communicative efficiency.

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed behavioral disorder in childhood and likely represents an extreme of normal behavior. ADHD significantly impacts learning in school-age children and leads to impaired functioning throughout the life span. There is strong evidence for a genetic etiology of the disorder, although putative alleles, principally in dopamine-related pathways suggested by candidate-gene studies, have very small effect sizes. We use affected-sib-pair analysis in 203 families to localize the first major susceptibility locus for ADHD to a 12-cM region on chromosome 16p13 (maximum LOD score 4.2; P=.000005), building upon an earlier genomewide scan of this disorder. The region overlaps that highlighted in three genome scans for autism, a disorder in which inattention and hyperactivity are common, and physically maps to a 7-Mb region on 16p13. These findings suggest that variations in a gene on 16p13 may contribute to common deficits found in both ADHD and autism.