Publications

Abstract

Usage-based approaches to language acquisition argue that children acquire the grammar of their target language using general-cognitive learning principles. The current paper reports on an experiment that tested a central assumption of the usage-based approach: argument structure patterns are connected to high frequency verbs that facilitate acquisition. Sixty children (N = 60) aged 4- and 6-years participated in a sentence recall/lexical priming experiment that manipulated the frequency with which the target verbs occurred in the finite sentential complement construction in English. The results showed that the children performed better on sentences that contained high frequency verbs. Furthermore, the children’s performance suggested that their knowledge of finite sentential complements relies most heavily on one particular verb – think, supporting arguments made by Goldberg [Goldberg, A.E., 2006. Constructions at Work: The Nature of Generalization in Language. Oxford University Press, Oxford], who argued that skewed input facilitates language learning.

Abstract

Two studies showed that adults who reported having an imaginary companion as a child differed from adults who did not on certain personality dimensions. The first yielded a higher mean on the Gough Creative Personality Scale for the group who had imaginary companions. Study 2 showed that such adults scored higher on the Achievement and Absorption subscales of Tellegen's Multidimensional Personality Questionnaire. The results suggest that some differences reported in the developmental literature may be observed in adults

Abstract

Somatic practices frequently use imagery, typically via verbal instructions, to scaffold sensorimotor organization and experience, a phenomenon we term “introjection”. We argue that introjection is an imagery practice in which sensorimotor and conceptual aspects are co-orchestrated, suggesting the necessity of crosstalk between somatics, phenomenology, psychology, embodied-enactive cognition, and linguistic research on embodied simulation. We presently focus on the scarcely addressed details of the process necessary to enact instructions of a literal or metaphoric nature through the body. Based on vignettes from dance, Feldenkrais, and Taichi practice, we describe introjection as a complex form of processual sense-making, in which context-interpretive, mental, attentional and physical sub-processes recursively braid. Our analysis focuses on how mental and body-related processes progressively align, inform and augment each other. This dialectic requires emphasis on the active body, which implies that uni-directional models (concept ⇒ body) are inadequate and should be replaced by interactionist alternatives (concept ⇔ body). Furthermore, we emphasize that both the source image itself and the body are specifically conceptualized for the context through constructive operations, and both evolve through their interplay. At this level introjection employs representational operations that are embedded in enactive dynamics of a fully situated person.

Abstract

Verbs are traditionally assumed to have an “argument structure”, which imposes various constraints on form and meaning of the noun phrases that go with the verb, and an “event structure”, which defines certain temporal characteristics of the “event” to which the verb relates. In this paper, I argue that these two structures should be brought together. The verb assigns descriptive properties to one or more arguments at one or more temporal intervals, hence verbs have an “argument-time structure”. This argument-time structure as well as the descriptive properties connected to it can be modified by various morphological and syntactic operations. This approach allows a relatively simple analysis of familiar but not well-defined temporal notions such as tense, aspect and Aktionsart. This will be illustrated for English. It will be shown that a few simple morphosyntactic operations on the argument-time structure might account for form and meaning of the perfect, the progressive, the passive and related constructions.

Abstract

In John has left London, it is clear that the event in question, John's leaving London, has occurred in the past, for example yesterday at ten. Why is it impossible, then, to make this the event time more explicit by such an adverbial, as in Yesterday at ten, John has left London? Any solution of this puzzle crucially hinges on the meaning assigned to the perfect, and the present perfect in particular. Two such solutions, a scope solution and the 'current relevance'-solution, are discussed and shown to be inadequate. A new, strictly compositional analysis of the English perfect is suggested, and it is argued that the imcompatibility of the present perfect and most past tense adverbials has neither syntactic nor semantic reasons but follows from a simple pragmatical constraint, called here the 'position-definiteness constraint'. It is the very same constraint, which also makes an utterance such as At ten, John had left at nine pragmatically odd, even if John indeed had left at nine, and hence the utterance is true.

Abstract

The size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways. Genes harboring lead variants are enriched for macrocephaly syndrome genes (37-fold) and high-fidelity cancer genes (9-fold), which is not seen for human height variants. Head size variants are also near genes preferentially expressed in intermediate progenitor cells, neural cells linked to evolutionary brain expansion. Our results indicate that genes regulating early brain and cranial growth incline to neoplasia later in life, irrespective of height. This warrants investigation of clinical implications of the link between head size and cancer.

Abstract

Multimodal rhythmic signalling abounds across animal taxa. Studying its mechanisms and functions can highlight adaptive components in highly complex rhythmic behaviours, like dance and music. Pinnipeds, such as the harbour seal, Phoca vitulina, are excellent comparative models to assess rhythmic capacities. Harbour seals engage in rhythmic percussive behaviours which, until now, have not been described in detail. In our study, eight zoo-housed harbour seals (two pups, two juveniles and four adults) were passively monitored by audio and video during their pupping/breeding season. All juvenile and adult animals performed percussive signalling with their fore flippers in agonistic conditions, both on land and in water. Flipper slap sequences produced on the ground or on the seals' bodies were often highly regular in their interval duration, that is, were quasi-isochronous, at a 200–600 beats/min pace. Three animals also showed significant lateralization in slapping. In contrast to slapping on land, display slapping in water, performed only by adult males, showed slower tempo by one order of magnitude, and a rather motivic temporal structure. Our work highlights that percussive communication is a significant part of harbour seals' behavioural repertoire. We hypothesize that its forms of rhythm production may reflect adaptive functions such as regulating internal states and advertising individual traits.

Abstract

To compare abstract structural and lexicalist accounts of syntactic processes in sentence formulation, we examined the effectiveness of nonidiomatic and idiomatic phrasal verbs in inducing structural generalizations. Three experiments made use of a syntactic priming paradigm in which participants recalled sentences they had read in rapid serial visual presentation. Prime and target sentences contained phrasal verbs with particles directly following the verb (pull off a sweatshirt) or following the direct object (pull a sweatshirt off). Idiomatic primes used verbs whose figurative meaning cannot be straightforwardly derived from the literal meaning of the main verb (e.g., pull off a robbery) and are commonly treated as stored lexical units. Particle placement in sentences was primed by both nonidiomatic and idiomatic verbs. Experiment 1 showed that the syntax of idiomatic and nonidiomatic phrasal verbs is amenable to priming, and Experiments 2 and 3 compared the priming patterns created by idiomatic and nonidiomatic primes. Despite differences in idiomaticity and structural flexibility, both types of phrasal verbs induced structural generalizations and differed little in their ability to do so. The findings are interpreted in terms of the role of abstract structural processes in language production.

Abstract

Source monitoring can be influenced by information that is external to the study context, such as beliefs and general knowledge (Johnson, Hashtroudi, & Lindsay, 1993). We investigated the extent to which metamnemonic judgments predict memory for items and sources when schematic information about the sources is or is not provided at encoding. Participants made judgments of learning (JOLs) to statements presented by two speakers and were informed of the occupation of each speaker either before or after the encoding session. Replicating earlier work, prior knowledge decreased participants' tendency to erroneously attribute statements to schematically consistent but episodically incorrect speakers. The origin of this effect can be understood by examining the relationship between JOLs and performance: JOLs were equally predictive of item and source memory in the absence of prior knowledge, but were exclusively predictive of source memory when participants knew of the relationship between speakers and statements during study. Background knowledge determines the information that people solicit in service of metamnemonic judgments, suggesting that these judgments reflect control processes during encoding that reduce schematic errors.

Abstract

Recognizing word boundaries in continuous speech requires detailed knowledge of the native language. In the first year of life, infants acquire considerable word segmentation abilities. Infants at this early stage in word segmentation rely to a large extent on the metrical pattern of their native language, at least in stress-based languages. In Dutch and English (both languages with a preferred trochaic stress pattern), segmentation of strong-weak words develops rapidly between 7 and 10 months of age. Nevertheless, trochaic languages contain not only strong-weak words but also words with a weak-strong stress pattern. In this article, we present electrophysiological evidence of the beginnings of weak-strong word segmentation in Dutch 10-month-olds. At this age, the ability to combine different cues for efficient word segmentation does not yet seem to be completely developed. We provide evidence that Dutch infants still largely rely on strong syllables, even for the segmentation of weak-strong words.

Abstract

The paper investigates the use of manner verbs (e.g. marcher 'to walk', courir 'to run') with so-called locative prepositions (e.g. dans 'in', sous 'under') in the descriptions of motion in French, as in Il a couru dans le bureau 'He ran in (to) the office', to explore the type of events such constructions express and the factors that influence their interpretation. Based on an extensive corpus survey, the study shows that, contrary to the general claim according to which such constructions express typically motion in some location, they are also frequently used to express change of location. The study discusses the interplay of various factors that contribute to the interpretation of these constructions, including semantic, aspectual and pragmatic factors.

Abstract

In order to investigate conflicts between semantics and syntax, we recorded ERPs, while participants read Dutch sentences. Sentences containing conflicts between syntax and semantics (Fred eats in a sandwich…/ Fred eats a restaurant…) elicited an N400. These results show that conflicts between syntax and semantics not necessarily lead to P600 effects and are in line with the processing competition account. According to this parallel account the syntactic and semantic processing streams are fully interactive and information from one level can influence the processing at another level. The relative strength of the cues of the processing streams determines which level is affected most strongly by the conflict. The processing competition account maintains the distinction between the N400 as index for semantic processing and the P600 as index for structural processing.

Abstract

Little is known about the genetic contribution to individual differences in neural networks subserving cognition function. In this functional magnetic resonance imaging (fMRI) twin study, we found a significant genetic influence on brain activation in neural networks supporting digit working memory tasks. Participants activating frontal-parietal networks responded faster than individuals relying more on language-related brain networks.There were genetic influences on brain activation in language-relevant brain circuits that were atypical for numerical working memory tasks as such. This suggests that differences in cognition might be related to brain activation patterns that differ qualitatively among individuals.

Abstract

We examined the extent to which cognate facilitation effects occurred in simultaneous bilingual children’s production and comprehension and how these were modulated by language dominance and language context. Bilingual Dutch-German children, ranging from Dutch-dominant to German-dominant, performed picture naming and auditory lexical decision tasks in single-language and dual-language contexts. Language context was manipulated with respect to the language of communication (with the experimenter and in instructional videos) and by means of proficiency tasks. Cognate facilitation effects emerged in both production and comprehension and interacted with both dominance and context. In a single-language context, stronger cognate facilitation effects were found for picture naming in children’s less dominant language, in line with previous studies on individual differences in lexical activation. In the dual-language context, this pattern was reversed, suggesting inhibition of the dominant language at the decision level. Similar effects were observed in lexical decision. These findings provide evidence for an integrated bilingual lexicon in simultaneous bilingual children and shed more light on the complex interplay between lexicon-internal and lexicon-external factors modulating the extent of lexical cross-linguistic influence more generally.

Abstract

In a between-language lexical priming study, we examined to what extent the two languages in a simultaneous bilingual child's lexicon interact, while taking individual differences in language exposure into account. Primary-school-aged Dutch–Greek bilinguals performed a primed picture selection task combined with eye-tracking. They matched pictures to auditorily presented Dutch target words preceded by Greek prime words. Their reaction times and eye movements were recorded. We tested for effects of between-language phonological priming, translation priming, and phonological priming through translation. Priming effects emerged in reaction times and eye movements in all three conditions, at different stages of processing, and unaffected by language exposure. These results extend previous findings for bilingual toddlers and bilingual adults. Processing similarities between these populations indicate that, across different stages of development, bilinguals have an integrated lexicon that is accessed in a language-nonselective way and is susceptible to interactions within and between different types of lexical representation.

Abstract

Objective: Stimulation-based language mapping approaches that are used pre- and intra-operatively employ predominantly overt language tasks requiring sufficient language pro-duction abilities. Yet, these production-based setups are often not feasible in brain tumor patients with severe expressive aphasia. This pilot study evaluated the feasibility and reliability of a newly developed language comprehension task with preoperative navigated transcranial magnetic stimulation (nTMS).
Methods: Fifteen healthy subjects and six brain tumor patients with severe expressiven aphasia unable to perform classic overt naming tasks underwent preoperative nTMS language mapping based on an auditory single-word Comprehension TAsk for Perioperative mapping (CompreTAP). Comprehension was probed by button-press responses to auditory stimuli, hence not requiring overt language responses. Positive comprehension areas were identified when stimulation elicited an incorrect or delayed button press. Error categories,case-wise cortical error rate distribution and inter-rater reliability between two experienced specialists were examined.
Results: Overall, the new setup showed to be feasible. Comprehension-disruptions induced by nTMS manifested in no responses, delayed or hesitant responses, searching behavior or selection of wrong target items across all patients and controls and could be performed even in patients with severe expressive aphasia. The analysis agreement between both specialists was substantial for classifying comprehension-positive and -negative sites. Extensive left-hemispheric individual cortical comprehension sites were identified for all patients. Apart from one case presenting with transient worsening of aphasic symptoms.

Abstract

The current study investigated gender (control) and number (target) agreement processing in Northern and non-Northern Norwegians living in Northern Norway. Participants varied in exposure to Northern Norwegian (NN) dialect(s), where number marking differs from most other Norwegian dialects. In a comprehension task involving reading NN dialect writing, P600 effects for number agreement were significantly affected by NN exposure. The more exposure the NN nonnatives had, the larger the P600 was, driven by the presence of number agreement (ungrammatical in NN). In contrast, less exposure correlated to the inverse: P600 driven by the absence of number agreement (ungrammatical in most other dialects). The NN natives showed P600 driven by the presence of number agreement regardless of exposure. These findings suggests that bilectalism entails the representation of distinct mental grammars for each dialect. However, like all instances of bilingualism, bilectalism exists on a continuum whereby linguistic processing is modulated by linguistic experience.

Abstract

A substantial literature exists using the syntactic priming methodology with children to test hypotheses regarding the acquisition of syntax, under the assumption that priming effects reveal both the presence of syntactic knowledge and the underlying nature of learning mechanisms supporting the acquisition of grammar. Here we present the first meta-analysis of syntactic priming studies in children. We identified 37 eligible studies and extracted 108 effect sizes corresponding to 76 samples of 2,378 unique participants. Our analysis confirmed a medium-to-large syntactic priming effect. The overall estimate of the priming effect was a log odds ratio of 1.44 (Cohen’s d = 0.80). This is equivalent to a structure that occurs 50 % of the time when unprimed occurring 81 % of the time when primed. Several variables moderated the magnitude of priming in children, including (i) within- or between-subjects design, (ii) lexical overlap, (iii) structural alternation investigated and, (iv) the animacy configuration of syntactic arguments. There was little evidence of publication bias in the size of the main priming effect, however, power analyses showed that, while studies typically have enough power to identify the basic priming effect, they are typically underpowered when their focus is on moderators of priming. The results provide a foundation for future research, suggesting several avenues of enquiry.

Abstract

Heterozygous mutations of the human FOXP2 gene cause a developmental disorder involving impaired learning and production of fluent spoken language. Previous investigations of its aetiology have focused on disturbed function of neural circuits involved in motor control. However, Foxp2 expression has been found in the cochlea and auditory brain centers and deficits in auditory processing could contribute to difficulties in speech learning and production. Here, we recorded auditory brainstem responses (ABR) to assess two heterozygous mouse models carrying distinct Foxp2 point mutations matching those found in humans with FOXP2-related speech/language impairment. Mice which carry a Foxp2-S321X nonsense mutation, yielding reduced dosage of Foxp2 protein, did not show systematic ABR differences from wildtype littermates. Given that speech/language disorders are observed in heterozygous humans with similar nonsense mutations (FOXP2-R328X), our findings suggest that auditory processing deficits up to the midbrain level are not causative for FOXP2-related language impairments. Interestingly, however, mice harboring a Foxp2-R552H missense mutation displayed systematic alterations in ABR waves with longer latencies (significant for waves I, III, IV) and smaller amplitudes (significant for waves I, IV) suggesting that either the synchrony of synaptic transmission in the cochlea and in auditory brainstem centers is affected, or fewer auditory nerve fibers and fewer neurons in auditory brainstem centers are activated compared to wildtypes. Therefore, the R552H mutation uncovers possible roles for Foxp2 in the development and/or function of the auditory system. Since ABR audiometry is easily accessible in humans, our data call for systematic testing of auditory functions in humans with FOXP2 mutations.

Abstract

Only a small number of studies have assessed structural differences between the two hemispheres during childhood and adolescence. However, the existing findings lack consistency or are restricted to a particular brain region, a specific brain feature, or a relatively narrow age range. Here, we investigated associations between brain asymmetry and age as well as sex in one of the largest pediatric samples to date (n = 4265), aged 1–18 years, scanned at 69 sites participating in the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium. Our study revealed that significant brain asymmetries already exist in childhood, but their magnitude and direction depend on the brain region examined and the morphometric measurement used (cortical volume or thickness, regional surface area, or subcortical volume). With respect to effects of age, some asymmetries became weaker over time while others became stronger; sometimes they even reversed direction. With respect to sex differences, the total number of regions exhibiting significant asymmetries was larger in females than in males, while the total number of measurements indicating significant asymmetries was larger in males (as we obtained more than one measurement per cortical region). The magnitude of the significant asymmetries was also greater in males. However, effect sizes for both age effects and sex differences were small. Taken together, these findings suggest that cerebral asymmetries are an inherent organizational pattern of the brain that manifests early in life. Overall, brain asymmetry appears to be relatively stable throughout childhood and adolescence, with some differential effects in males and females.

Abstract

Developmental Language Disorder (DLD) has been explained as either a deficit deriving from an abstract representational deficit or as emerging from difficulties in acquiring and coordinating multiple interacting cues guiding learning. These competing explanations are often difficult to decide between when tested on European languages. This paper reports an experimental study of relative clause (RC) production in Cantonese-speaking children with and without DLD, which enabled us to test multiple developmental predictions derived from one prominent theory − emergentism. Children with DLD (N = 22; aged 6;6–9;7) were compared with age-matched typically-developing peers (N = 23) and language-matched, typically-developing children (N = 21; aged 4;7–7;6) on a sentence repetition task. Results showed that children’s production across multiple RC types was influenced by structural frequency, general semantic complexity, and the linear order of constituents, with the DLD group performing worse than their age-matched and language-matched peers. The results are consistent with the emergentist explanation of DLD.

Abstract

Daily conversations contain many repetitions of identical and similar word forms. For bilinguals, the words can even come from the same or different languages. How do such repetitions affect the human word recognition system? The Bilingual Interactive Activation Plus (BIA+) model provides a theoretical and computational framework for understanding word recognition and word repetition in bilinguals. The model assumes that both phenomena involve a language non-selective process that is sensitive to the task context. By means of computer simulations, the model can specify both qualitatively and quantitatively how bilingual lexical processing in one language is affected by the other language. Our review discusses how BIA+ handles cross-linguistic repetition and masked orthographic priming data from two key empirical studies. We show that BIA+ can account for repetition priming effects within- and between-languages through the manipulation of resting-level activations of targets and neighbors (words sharing all but one letter with the target). The model also predicts cross-linguistic performance on within- and between-trial orthographic priming without appealing to conscious strategies or task schema competition as an explanation. At the end of the paper, we briefly evaluate the model and indicate future developments.

Abstract

Recursive procedures that allow placing a vocal signal inside another of a similar kind provide a neuro-computational blueprint for syntax and phonology in spoken language and human song. There are, however, no known vocal sequences among nonhuman primates arranged in self-embedded patterns that evince vocal recursion or potential incipient or evolutionary transitional forms thereof, suggesting a neuro-cognitive transformation exclusive to humans. Here, we uncover that wild flanged male orangutan long calls feature rhythmically isochronous call sequences nested within isochronous call sequences, consistent with two hierarchical strata. Remarkably, three temporally and acoustically distinct call rhythms in the lower stratum were not related to the overarching rhythm at the higher stratum by any low multiples, which suggests that these recursive structures were neither the result of parallel non-hierarchical procedures nor anatomical artifacts of bodily constraints or resonances. Findings represent a case of temporally recursive hominid vocal combinatorics in the absence of syntax, semantics, phonology, or music. Second-order combinatorics, ‘sequences within sequences’, involving hierarchically organized and cyclically structured vocal sounds in ancient hominids may have preluded the evolution of recursion in modern language-able humans.

Abstract

We present a coding system combined with an annotation tool for the analysis of gestural behavior. The NEUROGES coding system consists of three modules that progress from gesture kinetics to gesture function. Grounded on empirical neuropsychological and psychological studies, the theoretical assumption behind NEUROGES is that its main kinetic and functional movement categories are differentially associated with specific cognitive, emotional, and interactive functions. ELAN is a free, multimodal annotation tool for digital audio and video media. It supports multileveled transcription and complies with such standards as XML and Unicode. ELAN allows gesture categories to be stored with associated vocabularies that are reusable by means of template files. The combination of the NEUROGES coding system and the annotation tool ELAN creates an effective tool for empirical research on gestural behavior.

Abstract

If listening in adverse conditions is hard, then listening in a foreign language is doubly so: non-native listeners have to cope with both imperfect signals and imperfect knowledge. Comparison of native and non-native listener performance in speech-in-noise tasks helps to clarify the role of prior linguistic experience in speech perception, and, more directly, contributes to an understanding of the problems faced by language learners in everyday listening situations. This article reviews experimental studies on non-native listening in adverse conditions, organised around three principal contributory factors: the task facing listeners, the effect of adverse conditions on speech, and the differences among listener populations. Based on a comprehensive tabulation of key studies, we identify robust findings, research trends and gaps in current knowledge.

Abstract

The aim of this meta-analysis is twofold: (a) to assess cognitive impairments in isolated rapid eye movement (REM) sleep behavior disorder (iRBD) patients compared to healthy controls (HC); (b) to quantitatively estimate the risk of developing a neurodegenerative disease in iRBD patients according to baseline cognitive assessment. To address the first aim, cross-sectional studies including polysomnography-confirmed iRBD patients, HC, and reporting neuropsychological testing were included. To address the second aim, longitudinal studies including polysomnography-confirmed iRBD patients, reporting baseline neuropsychological testing for converted and still isolated patients separately were included. The literature search was conducted based on PRISMA guidelines and the protocol was registered at PROSPERO (CRD42021253427). Cross-sectional and longitudinal studies were searched from PubMed, Web of Science, Scopus, and Embase databases. Publication bias and statistical heterogeneity were assessed respectively by funnel plot asymmetry and using I2. Finally, a random-effect model was performed to pool the included studies. 75 cross-sectional (2,398 HC and 2,460 iRBD patients) and 11 longitudinal (495 iRBD patients) studies were selected. Cross-sectional studies showed that iRBD patients performed significantly worse in cognitive screening scores (random-effects (RE) model = –0.69), memory (RE model = –0.64), and executive function (RE model = –0.50) domains compared to HC. The survival analyses conducted for longitudinal studies revealed that lower executive function and language performance, as well as the presence of mild cognitive impairment (MCI), at baseline were associated with an increased risk of conversion at follow-up. Our study underlines the importance of a comprehensive neuropsychological assessment in the context of iRBD.

Abstract

Tail wagging is a conspicuous behaviour in domestic dogs (Canis familiaris). Despite how much meaning humans attribute to this display, its quantitative description and evolutionary history are rarely studied. We summarize what is known about the mechanism, ontogeny, function and evolution of this behaviour. We suggest two hypotheses to explain its increased occurrence and frequency in dogs compared to other canids. During the domestication process, enhanced rhythmic tail wagging behaviour could have (i) arisen as a by-product of selection for other traits, such as docility and tameness, or (ii) been directly selected by humans, due to our proclivity for rhythmic stimuli. We invite testing of these hypotheses through neurobiological and ethological experiments, which will shed light on one of the most readily observed yet understudied animal behaviours. Targeted tail wagging research can be a window into both canine ethology and the evolutionary history of characteristic human traits, such as our ability to perceive and produce rhythmic behaviours.

Abstract

Non-native speech is harder to understand than native speech. We demonstrate that this “processing
difficulty” causes non-native speakers to sound less credible. People judged trivia statements such as “Ants
don't sleep” as less true when spoken by a non-native than a native speaker. When people were made aware
of the source of their difficulty they were able to correct when the accent was mild but not when it was
heavy. This effect was not due to stereotypes of prejudice against foreigners because it occurred even though
speakers were merely reciting statements provided by a native speaker. Such reduction of credibility may
have an insidious impact on millions of people, who routinely communicate in a language which is not their
native tongue

Abstract

This paper introduces a special issue of Cognition on lexical access in speech production. Over the last quarter century, the psycholinguistic study of speaking, and in particular of accessing words in speech, received a major new impetus from the analysis of speech errors, dysfluencies and hesitations, from aphasiology, and from new paradigms in reaction time research. The emerging theoretical picture partitions the accessing process into two subprocesses, the selection of an appropriate lexical item (a “lemma”) from the mental lexicon, and the phonological encoding of that item, that is, the computation of a phonetic program for the item in the context of utterance. These two theoretical domains are successively introduced by outlining some core issues that have been or still have to be addressed. The final section discusses the controversial question whether phonological encoding can affect lexical selection. This partitioning is also followed in this special issue as a whole. There are, first, four papers on lexical selection, then three papers on phonological encoding, and finally one on the interaction between selection and phonological encoding.

Abstract

In their comment, Dell and O'Seaghdha (1991) adduced any effect on phonological probes for semantic alternatives to the activation of these probes in the lexical network. We argue that that interpretation is false and, in addition, that the model still cannot account for our data. Furthermore, and different from Dell and O'seaghda, we adduce semantic rebound to the lemma level, where it is so substantial that it should have shown up in our data. Finally, we question the function of feedback in a lexical network (other than eliciting speech errors) and discuss Dell's (1988) notion of a unified production-comprehension system.

Abstract

In his paper, MacKay reviews his Node Structure theory of error detection, but precedes it with a critical discussion of the Perceptual Loop theory of self-monitoring proposed in Levelt (1983, 1989). The present commentary is concerned with this latter critique and shows that there are more than casual problems with MacKay’s argumentation.

Abstract

Jones's system of constraints promises interesting insights into the typology of kin term systems. Three problems arise: (1) the conflation of categories with algorithms that assign them threatens to weaken the typological predictions; (2) OT-type constraints have little psychological plausibility; (3) the conflation of kin-term systems and kinship systems may underplay the "utility function" character of real kinship in action.

Abstract

A corpus of 350 naturally-occurring questions in videotaped interaction shows that questions and their responses in Yélî Dnye (the Papuan language of Rossel Island) both conform to clear universal expectations but also have a number of language-specific peculiarities. They conform in that polar and wh-questions are unrelated in form, wh-questions have the usual sort of special forms, and responses show the same priorities as in other languages (for fast cooperative, adequate answers). But, less expected perhaps, Yélî Dnye polar questions (excepting tags) are unmarked in both morphosyntax and prosody, and the responses include conventional facial expressions, conforming to the propositional response system type (so that assent to ‘He didn’t come?’ means ‘no, he didn’t’). These visual signals are facilitated by high levels of mutual gaze making rapid early responses possible. Tags can occur with non-interrogative illocutionary forces, and could be held to perform speech acts of their own. Wh-questions utilize about a dozen wh-forms, which are only optionally fronted, and there are some interesting specializations of forms (e.g. ‘who’ for any named entities other than places). Most questions of all types are genuinely information seeking, with 27% (mostly tags) seeking confirmation, 19% requesting repair.

Abstract

This short report draws attention to an interesting kind of configuration in the lexicon that seems to have escaped theoretical or systematic descriptive attention. These configurations, which we dub SEMPLATES, consist of an abstract structure or template, which is recurrently instantiated in a number of lexical sets, typically of different form classes. A number of examples from different language families are adduced, and generalizations made about the nature of semplates, which are contrasted to other, perhaps similar, phenomena

Abstract

In an earlier article (Levinson, 1987b), I raised the possibility that a Gricean theory of implicature might provide a systematic partial reduction of the Binding Conditions; the briefest of outlines is given in Section 2.1 below but the argumentation will be found in the earlier article. In this article I want, first, to show how that account might be further justified and extended, but then to introduce a radical alternative. This alternative uses the same pragmatic framework, but gives an account better adjusted to some languages. Finally, I shall attempt to show that both accounts can be combined by taking a diachronic perspective. The attraction of the combined account is that, suddenly, many facts about long-range reflexives and their associated logophoricity fall into place.

Abstract

This paper argues that the language sciences are on the brink of major changes in primary data, methods and theory. Reactions to ‘The myth of language universals’ ([Evans and Levinson, 2009a] and [Evans and Levinson, 2009b]) divide in response to these new challenges. Chomskyan-inspired ‘C-linguists’ defend a status quo, based on intuitive data and disparate universalizing abstract frameworks, reflecting 30 years of changing models. Linguists driven by interests in richer data and linguistic diversity, ‘D-linguists’, though more responsive to the new developments, have tended to lack an integrating framework. Here we outline such an integrative framework of the kind we were presupposing in ‘Myth’, namely a coevolutionary model of the interaction between mind and cultural linguistic traditions which puts variation central at all levels – a model that offers the right kind of response to the new challenges. In doing so we traverse the fundamental questions raised by the commentary in this special issue: What constitutes the data, what is the place of formal representations, how should linguistic comparison be done, what counts as explanation, what is the source of design in language? Radical changes in data, methods and theory are upon us. The future of the discipline will depend on responses to these changes: either the field turns in on itself and atrophies, or it modernizes, and tries to capitalize on the way language lies at the intersection of all the disciplines interested in human nature.

Abstract

Our study contributes to the less explored domain of lexical typology, focusing on semantic prosody and connotation. Semantic derogation, or pejoration of nouns referring to women, whereby such words acquire connotations and further denotations of social pejoration, immorality and/or loose sexuality, has been a very prominent question in studies on gender and language (change). It has been argued that pejoration emerges due to the general derogatory attitudes toward female referents. However, the evidence for systematic differences in connotations of female- vs. male-related words is fragmentary and often fairly impressionistic; moreover, many researchers argue that expressed sentiments toward women (as well as men) often are ambivalent. One should also expect gender differences in connotations to have decreased in the recent years, thanks to the advances of feminism and social progress. We test these ideas in a study of positive and negative connotations of feminine and masculine term pairs such as woman - man, girl - boy, wife - husband, etc. Sentences containing these words were sampled from diachronic corpora of English, Chinese and Russian, and sentiment scores for every word were obtained using two systems for Aspect-Based Sentiment Analysis: PyABSA, and OpenAI’s large language model GPT-3.5. The Generalized Linear Mixed Models of our data provide no indications of significantly more negative sentiment toward female referents in comparison with their male counterparts. However, some of the models suggest that female referents are more infrequently associated with neutral sentiment than male ones. Neither do our data support the hypothesis of the diachronic convergence between the genders. In sum, results suggest that pejoration is unlikely to be explained simply by negative attitudes to female referents in general.

Abstract

Measures of ‘humanness’, ‘coherence’ or ‘fluency’ are the mainstay of dialogue system evaluation, but they don’t target system capabilities and rarely offer actionable feedback. Reviewing recent work in this domain, we identify an opportunity for evaluation at the level of action sequences, rather than the more commonly targeted levels of whole conversations or single responses. We introduce interactive probes, an evaluation framework inspired by empirical work on social interaction that can help to systematically probe the capabilities of dialogue systems. We sketch some first probes in the domains of tellings and repair, two sequence types ubiquitous in human interaction and challenging for dialogue systems. We argue interactive probing can offer the requisite flexibility to keep up with developments in interactive language technologies and do justice to the open-endedness of action formation and ascription in interaction.

Abstract

Most neuroimaging studies are performed using one imaging method only, either functional magnetic resonance imaging (fMRI), electroencephalography (EEG), or magnetoencephalography (MEG). Information on both location and timing has been sought by recording fMRI and EEG, simultaneously, or MEG and fMRI in separate sessions. Such approaches assume similar active areas whether detected via hemodynamic or electrophysiological signatures. Direct comparisons, after independent analysis of data from each imaging modality, have been conducted primarily on low-level sensory processing. Here, we report MEG (timing and location) and fMRI (location) results in 11 subjects when they named pictures that depicted an action or an object. The experimental design was exactly the same for the two imaging modalities. The MEG data were analyzed with two standard approaches: a set of equivalent current dipoles and a distributed minimum norm estimate. The fMRI blood-oxygenlevel dependent (BOLD) data were subjected to the usual random-effect contrast analysis. At the group level, MEG and fMRI data showed fairly good convergence, with both overall activation patterns and task effects localizing to comparable cortical regions. There were some systematic discrepancies, however, and the correspondence was less compelling in the individual subjects. The present analysis should be helpful in reconciling results of fMRI and MEG studies on high-level cognitive functions

Abstract

One of the defining features of human language is displacement, the ability to make reference to absent entities. Here we show that prelinguistic, 12-month-old infants already can use a nonverbal pointing gesture to make reference to absent entities. We also show that chimpanzees—who can point for things they want humans to give them—do not point to refer to absent entities in the same way. These results demonstrate that the ability to communicate about absent but mutually known entities depends not on language, but rather on deeper social-cognitive skills that make acts of linguistic reference possible in the first place. These nonlinguistic skills for displaced reference emerged apparently only after humans' divergence from great apes some 6 million years ago.

Abstract

Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.

Abstract

* These authors contributed equally/shared first author
Deep convolutional neural networks (DCNNs) are able to partially predict brain activity during object categorization tasks, but factors contributing to this predictive power are not fully understood. Our study aimed to investigate the factors contributing to the predictive power of DCNNs in object categorization tasks. We compared the activity of four DCNN architectures with EEG recordings obtained from 62 human participants during an object categorization task. Previous physiological studies on object categorization have highlighted the importance of figure-ground segregation—the ability to distinguish objects from their backgrounds. Therefore, we investigated whether figure-ground segregation could explain the predictive power of DCNNs. Using a stimulus set consisting of identical target objects embedded in different backgrounds, we examined the influence of object background versus object category within both EEG and DCNN activity. Crucially, the recombination of naturalistic objects and experimentally controlled backgrounds creates a challenging and naturalistic task, while retaining experimental control. Our results showed that early EEG activity (< 100 msec) and early DCNN layers represent object background rather than object category. We also found that the ability of DCNNs to predict EEG activity is primarily influenced by how both systems process object backgrounds, rather than object categories. We demonstrated the role of figure-ground segregation as a potential prerequisite for recognition of object features, by contrasting the activations of trained and untrained (i.e., random weights) DCNNs. These findings suggest that both human visual cortex and DCNNs prioritize the segregation of object backgrounds and target objects to perform object categorization. Altogether, our study provides new insights into the mechanisms underlying object categorization as we demonstrated that both human visual cortex and DCNNs care deeply about object background.

Abstract

This study aims to advance our understanding of the nature and source(s) of individual differences in pragmatic language behavior over the adult lifespan. Across four story continuation experiments, we probed adults’ (N = 496 participants, ages 18–82) choice of referential forms (i.e., names vs. pronouns to refer to the main character). Our manipulations were based on Fossard et al.’s (2018) scale of referential complexity which varies according to the visual properties of the scene: low complexity (one character), intermediate complexity (two characters of different genders), and high complexity (two characters of the same gender). Since pronouns signal topic continuity (i.e., that the discourse will continue to be about the same referent), the use of pronouns is expected to decrease as referential complexity increases. The choice of names versus pronouns, therefore, provides insight into participants’ perception of the topicality of a referent, and whether that varies by age and cognitive capacity. In Experiment 1, we used the scale to test the association between referential choice, aging, and cognition, identifying a link between older adults’ switching skills and optimal referential choice. In Experiments 2–4, we tested novel manipulations that could impact the scale and found both the timing of a competitor referent’s presence and emphasis placed on competitors modulated referential choice, leading us to refine the scale for future use. Collectively, Experiments 1–4 highlight what type of contextual information is prioritized at different ages, revealing older adults’ preserved sensitivity to (visual) scene complexity but reduced sensitivity to linguistic prominence cues, compared to younger adults.

Abstract

This study investigated how adults over the lifespan flexibly adapt their use of prosocial speech acts when conveying bad news to communicative partners. Experiment 1a (N = 100 Scottish adults aged 18–72 years) assessed whether participants’ use of prosocial speech acts varied according to audience design considerations (i.e., whether or not the recipient of the news was directly affected). Experiment 1b (N = 100 Scottish adults aged 19–70 years) assessed whether participants adjusted for whether the bad news was more or less severe (an index of general knowledge). Younger adults displayed more flexible adaptation to the recipient manipulation, while no age differences were found for severity. These findings are consistent with prior work showing age-related decline in audience design but not in the use of general knowledge during language production. Experiment 2 further probed younger adults (N = 40, Scottish, aged 18–37 years) and older adults’ (N = 40, Scottish, aged 70–89 years) prosocial linguistic behavior by investigating whether health (vs. nonhealth-related) matters would affect responses. While older adults used prosocial speech acts to a greater extent than younger adults, they did not distinguish between conditions. Our results suggest that prosocial linguistic behavior is likely influenced by a combination of differences in audience design and communicative styles at different ages. Collectively, these findings highlight the importance of situating prosocial speech acts within the pragmatics and aging literature, allowing us to uncover the factors modulating prosocial linguistic behavior at different developmental stages.

Abstract

This study examined the development of declarative and procedural memory longitudinally in primary school-aged children. At present, although there is a general consensus that age-related improvements during this period can be found for declarative memory, there are conflicting data on the developmental trajectory of the procedural memory system. At Time 1 children aged around 5½ years were presented with measures of declarative and procedural memory. The tasks were then administered 12 months later. Performance on the declarative memory task was found to improve at a faster rate in comparison to the procedural memory task. The findings of the study support the view that multiple memory systems reach functional maturity at different points in development.

Abstract

The lack of diversity in the language sciences has increasingly been criticized as it holds the potential for producing flawed theories. Research on (i) geographically diverse language communities and (ii) on sign languages is necessary to corroborate, sharpen, and extend existing theories. This study contributes a case study of adapting a well-established paradigm to study the acquisition of sign phonology in Kata Kolok, a sign language of rural Bali, Indonesia. We conducted an experiment modeled after the familiarization paradigm with child signers of Kata Kolok. Traditional analyses of looking time did not yield significant differences between signing and non-signing children. Yet, additional behavioral analyses (attention, eye contact, hand behavior) suggest that children who are signers and those who are non-signers, as well as those who are hearing and those who are deaf, interact differently with the task. This study suggests limitations of the paradigm due to the ecology of sign languages and the sociocultural characteristics of the sample, calling for a mixed-methods approach. Ultimately, this paper aims to elucidate the diversity of adaptations necessary for experimental design, procedure, and analysis, and to offer a critical reflection on the contribution of similar efforts and the diversification of the field.

Abstract

Minimal expressions are at the heart of interaction: Interjections like "Huh?" and "Mhm" keep conversations flowing by establishing and reinforcing intersubjectivity among interlocutors. Crosslinguistic research has identified that similar interactional pressures can yield structurally similar words (e.g., to initiate repair across languages). While crosslinguistic comparisons that include signed languages remain uncommon, recent work has revealed similarities in discourse management strategies among signers and speakers that share much of their cultural background. This study contributes a crossmodal comparison of repair initiators and continuers in speakers of English and signers of British Sign Language (BSL). We combine qualitative and quantitative analyses of data from sixteen English speakers and sixteen BSL signers, resulting in the following: First, the interactional infrastructure drawn upon by speakers and signers overwhelmingly relies on behaviors of the head, face, and body; these are used alone or sometimes in combination with verbal elements (i.e., spoken words or manual signs), while verbal strategies alone are rare. Second, discourse management strategies are remarkably similar in form across the two languages: A held eye gaze or freeze-look is the predominant repair initiator and head nodding the main continuer. These results suggest a modality-agnostic preference for visual strategies that do not occupy the primary articulators, one that we propose is founded in recipiency; people maintain the flow of communication following principles of minimal effort and minimal interruption.

Abstract

This article reports on research which seeks to compare and measure the similarities between phonetic transcriptions in the analysis of relationships between varieties of English. It addresses the question of whether these varieties have been converging, diverging, or maintaining equilibrium as a result of endogenous and exogenous phonetic and phonological changes. We argue that it is only possible to identify such patterns of change by the simultaneous comparison of a wide range of varieties of a language across a data set that has not been specifically selected to highlight those changes that are believed to be important. Our analysis suggests that although there has been an obvious reduction in regional variation with the loss of traditional dialects of English and Scots, there has not been any significant convergence (or divergence) of regional accents of English in recent decades, despite the rapid spread of a number of features such as TH-fronting.

Abstract

Spoken language comprehension requires abstraction of linguistic information from speech, but the interaction between auditory and linguistic processing of speech remains poorly understood. Here, we investigate the nature of this abstraction using neural responses recorded intracranially while participants listened to conversational English speech. Capitalizing on multiple, language-specific patterns where phonological and acoustic information diverge, we demonstrate the causal efficacy of the phoneme as a unit of analysis and dissociate the unique contributions of phonemic and spectrographic information to neural responses. Quantitive higher-order response models also reveal that unique contributions of phonological information are carried in the covariance structure of the stimulus-response relationship. This suggests that linguistic abstraction is shaped by neurobiological mechanisms that involve integration across multiple spectro-temporal features and prior phonological information. These results link speech acoustics to phonology and morphosyntax, substantiating predictions about abstractness in linguistic theory and providing evidence for the acoustic features that support that abstraction.

Abstract

The linguistic and cognitive sciences have severely underestimated the degree of linguistic diversity in the world. Part of the reason for this is that we have projected assumptions based on English and familiar languages onto the rest. We focus on some distortions this has introduced, especially in the study of semantics.

Abstract

The goal of the study was to examine whether speakers naming pairs of objects would retrieve the names of the objects in parallel or in equence. To this end, we recorded the speakers’ eye movements and determined whether the difficulty of retrieving the name of the 2nd object affected the duration of the gazes to the 1st object. Two experiments, which differed in the spatial arrangement of the objects, showed that the speakers looked longer at the 1st object when the name of the 2nd object was easy than when it was more difficult to retrieve. Thus, the easy 2nd-object names interfered more with the processing of the 1st object than the more difficult 2nd-object names. In the 3rd experiment, the processing of the 1st object was rendered more difficult by presenting it upside down. No effect of 2nd-object difficulty on the gaze duration for the 1st object was found. These results suggest that speakers can retrieve the names of a foveated and an extrafoveal object in parallel, provided that the processing of the foveated object is not too demanding

Abstract

Comprehension of verb-phrase ellipsis (VPE) requires reevaluation of recently processed constituents, which often necessitates retrieval of information about the elided constituent from memory. A. E. Martin and B. McElree (2008) argued that representations formed during comprehension are content addressable and that VPE antecedents are retrieved from memory via a cue-dependent direct-access pointer rather than via a search process. This hypothesis was further tested by manipulating the location of interfering material—either before the onset of the antecedent (proactive interference; PI) or intervening between antecedent and ellipsis site (retroactive interference; RI). The speed–accuracy tradeoff procedure was used to measure the time course of VPE processing. The location of the interfering material affected VPE comprehension accuracy: RI conditions engendered lower accuracy than PI conditions. Crucially, location did not affect the speed of processing VPE, which is inconsistent with both forward and backward search mechanisms. The observed time-course profiles are consistent with the hypothesis that VPE antecedents are retrieved via a cue-dependent direct-access operation. (PsycINFO Database Record (c) 2016 APA, all rights reserved)

Abstract

Episodic memory, as defined by Tulving, can be described in terms of behavioural elements (what, where and when information) but it is also accompained by an awareness of one’s past (chronesthesia) and a subjective conscious experience (autonoetic awareness). Recent experiments have shown that corvids and rodents recall the where, what and when of an event. This capability has been called episodic-like memory because it only fulfils the behavioural criteria for episodic memory. We tested seven chimpanzees, three orangutans and two bonobos of various ages by adapting two paradigms, originally developed by Clayton and colleagues to test scrub jays. In Experiment 1, subjects were fed preferred but perishable food (frozen juice) and less preferred but non-perishable food (grape). After the food items were hidden, subjects could choose one of them either after 5 min or 1 h. The frozen juice was still available after 5 min but melted after 1 h and became unobtainable. Apes chose the frozen juice significantly more after 5 min and the grape after 1 h. In Experiment 2, subjects faced two baiting events happening at different times, yet they formed an integrated memory for the location and time of the baiting event for particular food items. We also included a memory task that required no temporal encoding. Our results showed that apes remember in an integrated fashion what, where and when (i.e., how long ago) an event happened; that is, apes distinguished between different events in which the same food items were hidden in different places at different times. The temporal control of their choices was not dependent on the familiarity of the platforms where the food was hidden. Chimpanzees’ and bonobos’ performance in the temporal encoding task was age-dependent, following an inverted U-shaped distribution. The age had no effect on the performance of the subjects in the task that required no temporal encoding.

Abstract

Understanding the lyrics of many contemporary songs is difficult, and an earlier study [Hidalgo-Barnes, M., Massaro, D.W., 2007. Read my lips: an animated face helps communicate musical lyrics. Psychomusicology 19, 3–12] showed a benefit for lyrics recognition when seeing a computer-animated talking head (Baldi) mouthing the lyrics along with hearing the singer. However, the contribution of visual information was relatively small compared to what is usually found for speech. In the current experiments, our goal was to determine why the face appears to contribute less when aligned with sung lyrics than when aligned with normal speech presented in noise. The first experiment compared the contribution of the talking head with the originally sung lyrics versus the case when it was aligned with the Festival text-to-speech synthesis (TtS) spoken at the original duration of the song’s lyrics. A small and similar influence of the face was found in both conditions. In the three experiments, we compared the presence of the face when the durations of the TtS were equated with the duration of the original musical lyrics to the case when the lyrics were read with typical TtS durations and this speech embedded in noise. The results indicated that the unusual temporally distorted durations of musical lyrics decreases the contribution of the visible speech from the face.

Abstract

Classical galactosaemia (CG) is a hereditary disease in galactose metabolism that despite dietary treatment is characterized by a wide range of cognitive deficits, among which is language production. CG brain functioning has been studied with several neuroimaging techniques, which revealed both structural and functional atypicalities. In the present study, for the first time, we compared the oscillatory dynamics, especially the power spectrum and time–frequency representations (TFR), in the electroencephalography (EEG) of CG patients and healthy controls while they were performing a language production task. Twenty-one CG patients and 19 healthy controls described animated scenes, either in full sentences or in words, indicating two levels of complexity in syntactic planning. Based on previous work on the P300 event related potential (ERP) and its relation with theta frequency, we hypothesized that the oscillatory activity of patients and controls would differ in theta power and TFR. With regard to behavior, reaction times showed that patients are slower, reflecting the language deficit. In the power spectrum, we observed significant higher power in patients in delta (1–3 Hz), theta (4–7 Hz), beta (15–30 Hz) and gamma (30–70 Hz) frequencies, but not in alpha (8–12 Hz), suggesting an atypical oscillatory profile. The time-frequency analysis revealed significantly weaker event-related theta synchronization (ERS) and alpha desynchronization (ERD) in patients in the sentence condition. The data support the hypothesis that CG language difficulties relate to theta–alpha brain oscillations.

Abstract

Cognitive approaches to religious phenomena have attracted considerable interdisciplinary attention since their emergence a couple of decades ago. Proponents offer explanatory accounts of the content and transmission of religious thought and behavior in terms of underlying cognition. A central claim is that the cross-cultural recurrence and historical persistence of religion is attributable to the cognitive naturalness of religious ideas, i.e., attributable to the readiness, the ease, and the speed with which human minds acquire and process popular religious representations. In this article, we primarily provide an introductory summary of foundational questions, assumptions, and hypotheses in this field, including some discussion of features distinguishing cognitive science approaches to religion from established psychological approaches. Relevant ethnographic and experimental evidence illustrate and substantiate core claims. Finally, we briefly consider the broader implications of these cognitive approaches for the appropriateness of ‘religion’ as an explanatorily useful category in the social sciences.

Abstract

The extent to which variation in chromatin structure and transcription factor binding may influence gene expression, and thus underlie or contribute to variation in phenotype, is unknown. To address this question, we cataloged both individual-to-individual variation and differences between homologous chromosomes within the same individual (allele-specific variation) in chromatin structure and transcription factor binding in lymphoblastoid cells derived from individuals of geographically diverse ancestry. Ten percent of active chromatin sites were individual-specific; a similar proportion were allele-specific. Both individual-specific and allele-specific sites were commonly transmitted from parent to child, which suggests that they are heritable features of the human genome. Our study shows that heritable chromatin status and transcription factor binding differ as a result of genetic variation and may underlie phenotypic variation in humans.

Abstract

The strongest support for feedback in speech perception comes from evidence of apparent lexical influence on prelexical fricative-stop compensation for coarticulation. Lexical knowledge (e.g., that the ambiguous final fricative of Christma? should be [s]) apparently influences perception of following stops. We argue that all such previous demonstrations can be explained without invoking lexical feedback. In particular, we show that one demonstration [Magnuson, J. S., McMurray, B., Tanenhaus, M. K., & Aslin, R. N. (2003). Lexical effects on compensation for coarticulation: The ghost of Christmash past. Cognitive Science, 27, 285–298] involved experimentally-induced biases (from 16 practice trials) rather than feedback. We found that the direction of the compensation effect depended on whether practice stimuli were words or nonwords. When both were used, there was no lexically-mediated compensation. Across experiments, however, there were lexical effects on fricative identification. This dissociation (lexical involvement in the fricative decisions but not in the following stop decisions made on the same trials) challenges interactive models in which feedback should cause both effects. We conclude that the prelexical level is sensitive to experimentally-induced phoneme-sequence biases, but that there is no feedback during speech perception.

Abstract

BACKGROUND: Human and animal prion diseases are under genetic control, but apart from PRNP (the gene that encodes the prion protein), we understand little about human susceptibility to bovine spongiform encephalopathy (BSE) prions, the causal agent of variant Creutzfeldt-Jakob disease (vCJD).METHODS: We did a genome-wide association study of the risk of vCJD and tested for replication of our findings in samples from many categories of human prion disease (929 samples) and control samples from the UK and Papua New Guinea (4254 samples), including controls in the UK who were genotyped by the Wellcome Trust Case Control Consortium. We also did follow-up analyses of the genetic control of the clinical phenotype of prion disease and analysed candidate gene expression in a mouse cellular model of prion infection. FINDINGS: The PRNP locus was strongly associated with risk across several markers and all categories of prion disease (best single SNP [single nucleotide polymorphism] association in vCJD p=2.5 x 10(-17); best haplotypic association in vCJD p=1 x 10(-24)). Although the main contribution to disease risk was conferred by PRNP polymorphic codon 129, another nearby SNP conferred increased risk of vCJD. In addition to PRNP, one technically validated SNP association upstream of RARB (the gene that encodes retinoic acid receptor beta) had nominal genome-wide significance (p=1.9 x 10(-7)). A similar association was found in a small sample of patients with iatrogenic CJD (p=0.030) but not in patients with sporadic CJD (sCJD) or kuru. In cultured cells, retinoic acid regulates the expression of the prion protein. We found an association with acquired prion disease, including vCJD (p=5.6 x 10(-5)), kuru incubation time (p=0.017), and resistance to kuru (p=2.5 x 10(-4)), in a region upstream of STMN2 (the gene that encodes SCG10). The risk genotype was not associated with sCJD but conferred an earlier age of onset. Furthermore, expression of Stmn2 was reduced 30-fold post-infection in a mouse cellular model of prion disease. INTERPRETATION: The polymorphic codon 129 of PRNP was the main genetic risk factor for vCJD; however, additional candidate loci have been identified, which justifies functional analyses of these biological pathways in prion disease.

Abstract

The ratio of the lengths of an individual's second to fourth digit (2D:4D) is commonly used as a noninvasive retrospective biomarker for prenatal androgen exposure. In order to identify the genetic determinants of 2D:4D, we applied a genome-wide association approach to 1507 11-year-old children from the Avon Longitudinal Study of Parents and Children (ALSPAC) in whom 2D:4D ratio had been measured, as well as a sample of 1382 12- to 16-year-olds from the Brisbane Adolescent Twin Study. A meta-analysis of the two scans identified a single variant in the LIN28B gene that was strongly associated with 2D:4D (rs314277: p = 4.1 x 10(-8)) and was subsequently independently replicated in an additional 3659 children from the ALSPAC cohort (p = 1.53 x 10(-6)). The minor allele of the rs314277 variant has previously been linked to increased height and delayed age at menarche, but in our study it was associated with increased 2D:4D in the direction opposite to that of previous reports on the correlation between 2D:4D and age at menarche. Our findings call into question the validity of 2D:4D as a simplistic retrospective biomarker for prenatal testosterone exposure.