Publications

Abstract

Human joint action is inherently cooperative, manifested in the collaborative efforts of participants to minimize communicative trouble through interactive repair. Although interactive repair requires sophisticated cognitive abilities,
it can be dissected into basic building blocks shared with non-human animal species. A review of the primate literature shows that interactionally contingent signal sequences are at least common among species of nonhuman great apes, suggesting a gradual evolution of repair. To pioneer a cross-species assessment of repair this paper aims at (i) identifying necessary precursors of human interactive repair; (ii) proposing a coding framework for its comparative study in humans and non-human species; and (iii) using this framework to analyse examples of interactions of humans (adults/children) and non-human great apes. We hope this paper will serve as a primer for cross-species comparisons of communicative breakdowns and how they are repaired.

Abstract

Understanding spoken language requires transforming ambiguous acoustic streams into a hierarchy of representations, from phonemes to meaning. It has been suggested that the brain uses prediction to guide the interpretation of incoming input. However, the role of prediction in language processing remains disputed, with disagreement about both the ubiquity and representational nature of predictions. Here, we address both issues by analyzing brain recordings of participants listening to audiobooks, and using a deep neural network (GPT-2) to precisely quantify contextual predictions. First, we establish that brain responses to words are modulated by ubiquitous predictions. Next, we disentangle model-based predictions into distinct dimensions, revealing dissociable neural signatures of predictions about syntactic category (parts of speech), phonemes, and semantics. Finally, we show that high-level (word) predictions inform low-level (phoneme) predictions, supporting hierarchical predictive processing. Together, these results underscore the ubiquity of prediction in language processing, showing that the brain spontaneously predicts upcoming language at multiple levels of abstraction.

Abstract

Culture, a pillar of the remarkable ecological success of humans, is increasingly recognized as a powerful force structuring nonhuman animal populations. A key gap between these two types of culture is quantitative evidence of symbolic markers—seemingly arbitrary traits that function as reliable indicators of cultural group membership to conspecifics. Using acoustic data collected from 23 Pacific Ocean locations, we provide quantitative evidence that certain sperm whale acoustic signals exhibit spatial patterns consistent with a symbolic marker function. Culture segments sperm whale populations into behaviorally distinct clans, which are defined based on dialects of stereotyped click patterns (codas). We classified 23,429 codas into types using contaminated mixture models and hierarchically clustered coda repertoires into seven clans based on similarities in coda usage; then we evaluated whether coda usage varied with geographic distance within clans or with spatial overlap between clans. Similarities in within-clan usage of both “identity codas” (coda types diagnostic of clan identity) and “nonidentity codas” (coda types used by multiple clans) decrease as space between repertoire recording locations increases. However, between-clan similarity in identity, but not nonidentity, coda usage decreases as clan spatial overlap increases. This matches expectations if sympatry is related to a measurable pressure to diversify to make cultural divisions sharper, thereby providing evidence that identity codas function as symbolic markers of clan identity. Our study provides quantitative evidence of arbitrary traits, resembling human ethnic markers, conveying cultural identity outside of humans, and highlights remarkable similarities in the distributions of human ethnolinguistic groups and sperm whale clans.

Abstract

Previous research suggests that literacy, specifically learning alphabetic letter-to-phoneme mappings, modifies online speech processing, and enhances brain responses, as indexed by the blood-oxygenation level dependent signal (BOLD), to speech in auditory areas associated with phonological processing (Dehaene et al., 2010). However, alphabets are not the only orthographic systems in use in the world, and hundreds of millions of individuals speak languages that are not written using alphabets. In order to make claims that literacy per se has broad and general consequences for brain responses to speech, one must seek confirmatory evidence from non-alphabetic literacy. To this end, we conducted a longitudinal fMRI study in India probing the effect of literacy in Devanagari, an abugida, on functional connectivity and cerebral responses to speech in 91 variously literate Hindi-speaking male and female human participants. Twenty-two completely illiterate participants underwent six months of reading and writing training. Devanagari literacy increases functional connectivity between acoustic-phonetic and graphomotor brain areas, but we find no evidence that literacy changes brain responses to speech, either in cross-sectional or longitudinal analyses. These findings shows that a dramatic reconfiguration of the neurofunctional substrates of online speech processing may not be a universal result of learning to read, and suggest that the influence of writing on speech processing should also be investigated.

Abstract

We used functional magnetic resonance imaging (fMRI) to investigate the neural basis of comprehension and perceptual learning of artificially degraded [noise vocoded (NV)] speech. Fifteen participants were scanned while listening to 6-channel vocoded words, which are difficult for naive listeners to comprehend, but can be readily learned with appropriate feedback presentations. During three test blocks, we compared responses to potentially intelligible NV words, incomprehensible distorted words and clear speech. Training sessions were interleaved with the test sessions and included paired presentation of clear then noise-vocoded words: a type of feedback that enhances perceptual learning. Listeners' comprehension of NV words improved significantly as a consequence of training. Listening to NV compared to clear speech activated left insula, and prefrontal and motor cortices. These areas, which are implicated in speech production, may play an active role in supporting the comprehension of degraded speech. Elevated activation in the precentral gyrus during paired clear-then-distorted presentations that enhance learning further suggests a role for articulatory representations of speech in perceptual learning of degraded speech.

Abstract

Speech comprehension is resistant to acoustic distortion in the input, reflecting listeners' ability to adjust perceptual processes to match the speech input. This adjustment is reflected in improved comprehension of distorted speech with experience. For noise vocoding, a manipulation that removes spectral detail from speech, listeners' word report showed a significantly greater improvement over trials for listeners that heard clear speech presentations before rather than after hearing distorted speech (clear-then-distorted compared with distorted-then-clear feedback, in Experiment 1). This perceptual learning generalized to untrained words suggesting a sublexical locus for learning and was equivalent for word and nonword training stimuli (Experiment 2). These findings point to the crucial involvement of phonological short-term memory and top-down processes in the perceptual learning of noise-vocoded speech. Similar processes may facilitate comprehension of speech in an unfamiliar accent or following cochlear implantation.

Abstract

Alexithymia concerns a difficulty identifying and communicating one’s own emotions, and a tendency towards externally-oriented thinking. Recent work argues that such alexithymic traits are due to altered arousal response and poor subjective awareness of “objective” arousal responses. Although there are individual differences within the general population in identifying and describing emotions, extant research has focused on highly alexithymic individuals. Here we investigated whether mean arousal and concordance between subjective and objective arousal underpin individual differences in alexithymic traits in a general population sample. Participants rated subjective arousal responses to 60 images from the International Affective Picture System whilst their skin conductance was recorded. The Autism Quotient was employed to control for autistic traits in the general population. Analysis using linear models demonstrated that mean arousal significantly predicted Toronto Alexithymia Scale scores above and beyond autistic traits, but concordance scores did not. This indicates that, whilst objective arousal is a useful predictor in populations that are both above and below the cut-off values for alexithymia, concordance scores between objective and subjective arousal do not predict variation in alexithymic traits in the general population.

Abstract

Height-pitch associations are claimed to be universal and independent of language, but this claim remains controversial. The present study sheds new light on this debate with a multimodal analysis of individual sound and melody descriptions obtained in an interactive communication paradigm with speakers of Dutch and Farsi. The findings reveal that, in contrast to Dutch speakers, Farsi speakers do not use a height-pitch metaphor consistently in speech. Both Dutch and Farsi speakers’ co-speech gestures did reveal a mapping of higher pitches to higher space and lower pitches to lower space, and this gesture space-pitch mapping tended to co-occur with corresponding spatial words (high-low). However, this mapping was much weaker in Farsi speakers than Dutch speakers. This suggests that cross-linguistic differences shape the conceptualization of pitch and further calls into question the universality of height-pitch associations.

Abstract

The view put forward here is that visual bodily signals play a core role in human communication and the coordination of minds. Critically, this role goes far beyond referential and propositional meaning. The human communication system that we consider to be the explanandum in the evolution of language thus is not spoken language. It is, instead, a deeply multimodal, multilayered, multifunctional system that developed—and survived—owing to the extraordinary flexibility and adaptability that it endows us with. Beyond their undisputed iconic power, visual bodily signals (manual and head gestures, facial expressions, gaze, torso movements) fundamentally contribute to key pragmatic processes in modern human communication. This contribution becomes particularly evident with a focus that includes non-iconic manual signals, non-manual signals and signal combinations. Such a focus also needs to consider meaning encoded not just via iconic mappings, since kinematic modulations and interaction-bound meaning are additional properties equipping the body with striking pragmatic capacities. Some of these capacities, or its precursors, may have already been present in the last common ancestor we share with the great apes and may qualify as early versions of the components constituting the hypothesized interaction engine.

Abstract

The given-new contract entails that speakers must distinguish for their addressee whether references are new or already part of their dialogue. Past research had found that, in a monologue to a listener, speakers shortened repeated words. However, the notion of the given-new contract is inherently dialogic, with an addressee and the availability of co-speech gestures. Here, two face-to-face dialogue experiments tested whether gesture duration also follows the given-new contract. In Experiment 1, four experimental sequences confirmed that when speakers repeated their gestures, they shortened the duration significantly. Experiment 2 replicated the effect with spontaneous gestures in a different task. This experiment also extended earlier results with words, confirming that speakers shortened their repeated words significantly in a multimodal dialogue setting, the basic form of language use. Because words and gestures were not necessarily redundant, these results offer another instance in which gestures and words independently serve pragmatic requirements of dialogue.

Abstract

Abstract Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA-ADHD and ENIGMA-ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA-ADHD and -ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case–control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case–control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow-up analyses continue that include more imaging modalities (diffusion MRI and resting-state functional MRI), collaborations with other large databases, and samples with dual diagnoses.

Abstract

Background Reduced total brain volume is a consistent finding in children with Attention Deficit/Hyperactivity Disorder (ADHD). In order to get a better understanding of the neurobiology of ADHD, we take the first step in studying the dimensionality of current self-reported adult ADHD symptoms, by looking at its relation with total brain volume. Methodology/Principal Findings In a sample of 652 highly educated adults, the association between total brain volume, assessed with magnetic resonance imaging, and current number of self-reported ADHD symptoms was studied. The results showed an association between these self-reported ADHD symptoms and total brain volume. Post-hoc analysis revealed that the symptom domain of inattention had the strongest association with total brain volume. In addition, the threshold for impairment coincides with the threshold for brain volume reduction. Conclusions/Significance This finding improves our understanding of the biological substrates of self-reported ADHD symptoms, and suggests total brain volume as a target intermediate phenotype for future gene-finding in ADHD.

Abstract

We investigated 4- and 5-year-old children’s mapping strategies in a spatial task. Children were required to find a picture in an array of three identical cups after observing another picture being hidden in another array of three cups. The arrays were either aligned one behind the other in two rows or placed side by side forming one line. Moreover, children were rewarded for two different mapping strategies. Half of the children needed to choose a cup that held the same relative position as the rewarded cup in the other array; they needed to map left–left, middle–middle, and right–right cups together (aligned mapping), which required encoding and mapping of two relations (e.g., the cup left of the middle cup and left of the right cup). The other half needed to map together the cups that held the same relation to the table’s spatial features—the cups at the edges, the middle cups, and the cups in the middle of the table (landmark mapping)—which required encoding and mapping of one relation (e.g., the cup at the table’s edge). Results showed that children’s success was constellation dependent; performance was higher when the arrays were aligned one behind the other in two rows than when they were placed side by side. Furthermore, children showed a preference for landmark mapping over aligned mapping.

Abstract

Two eyetracking experiments tested for activation of category coordinate and perceptually related concepts when speakers prepare the name of an object. Speakers saw four visual objects in a 2 × 2 array and identified and named a target picture on the basis of either category (e.g., "What is the name of the musical instrument?") or visual-form (e.g., "What is the name of the circular object?") instructions. There were more fixations on visual-form competitors and category coordinate competitors than on unrelated objects during name preparation, but the increased overt attention did not affect naming latencies. The data demonstrate that eye movements are a sensitive measure of the overlap between the conceptual (including visual-form) information that is accessed in preparation for word production and the conceptual knowledge associated with visual objects. Furthermore, these results suggest that semantic activation of competitor concepts does not necessarily affect lexical selection, contrary to the predictions of lexical-selection-by-competition accounts (e.g., Levelt, Roelofs, & Meyer, 1999).

Abstract

A recent trend in psycholinguistic research has been to posit prediction as an essential function of language processing. The present paper develops a linguistic perspective on viewing prediction in terms of pre-activation. We describe what predictions are and how they are produced. Our basic premises are that (a) no prediction can be made without knowledge to support it; and (b) it is therefore necessary to characterize the precise form of that knowledge, as revealed by a suitable theory of linguistic representations. We describe the Parallel Architecture (PA: Jackendoff, 2002; Jackendoff and Audring, 2020), which makes explicit our commitments about linguistic representations, and we develop an account of processing based on these representations. Crucial to our account is that what have been traditionally treated as derivational rules of grammar are formalized by the PA as lexical items, encoded in the same format as words. We then present a theory of prediction in these terms: linguistic input activates lexical items whose beginning (or incipit) corresponds to the input encountered so far; and prediction amounts to pre-activation of the as yet unheard parts of those lexical items (the remainder). Thus the generation of predictions is a natural byproduct of processing linguistic representations. We conclude that the PA perspective on pre-activation provides a plausible account of prediction in language processing that bridges linguistic and psycholinguistic theorizing.

Abstract

The experimental investigation of language-mediated visual attention is a promising way to study the interaction of the cognitive systems involved in language, vision, attention, and memory. Here we highlight four challenges for a mechanistic account of this oculomotor behavior: the levels of representation at which language-derived and vision-derived representations are integrated; attentional mechanisms; types of memory; and the degree of individual and group differences. Central points in our discussion are (a) the possibility that local microcircuitries involving feedforward and feedback loops instantiate a common representational substrate of linguistic and non-linguistic information and attention; and (b) that an explicit working memory may be central to explaining interactions between language and visual attention. We conclude that a synthesis of further experimental evidence from a variety of fields of inquiry and the testing of distinct, non-student, participant populations will prove to be critical.

Abstract

Typical adults read remarkably quickly. Such fast reading is facilitated by brain processes that are sensitive to both word frequency and contextual constraints. It is debated as to whether these attributes have additive or interactive effects on language processing in the brain. We investigated this issue by analysing existing magnetoencephalography data from 99 participants reading intact and scrambled sentences. Using a cross-validated model comparison scheme, we found that lexical frequency predicted the word-by-word elicited MEG signal in a widespread cortical network, irrespective of sentential context. In contrast, index (ordinal word position) was more strongly encoded in sentence words, in left front-temporal areas. This confirms that frequency influences word processing independently of predictability, and that contextual constraints affect word-by-word brain responses. With a conservative multiple comparisons correction, only the interaction between lexical frequency and surprisal survived, in anterior temporal and frontal cortex, and not between lexical frequency and entropy, nor between lexical frequency and index. However, interestingly, the uncorrected index*frequency interaction revealed an effect in left frontal and temporal cortex that reversed in time and space for intact compared to scrambled sentences. Finally, we provide evidence to suggest that, in sentences, lexical frequency and predictability may independently influence early (<150ms) and late stages of word processing, but interact during later stages of word processing (>150-250ms), thus helping to converge previous contradictory eye-tracking and electrophysiological literature. Current neuro-cognitive models of reading would benefit from accounting for these differing effects of lexical frequency and predictability on different stages of word processing.

Abstract

Traditional experiments indicate that prediction is important for efficient speech processing. In three virtual reality visual world paradigm experiments, we tested whether such findings hold in naturalistic settings (Experiment 1) and provided novel insights into whether disfluencies in speech (repairs/hesitations) inform one’s predictions in rich environments (Experiments 2–3). Experiment 1 supports that listeners predict upcoming speech in naturalistic environments, with higher proportions of anticipatory target fixations in predictable compared to unpredictable trials. In Experiments 2–3, disfluencies reduced anticipatory fixations towards predicted referents, compared to conjunction (Experiment 2) and fluent (Experiment 3) sentences. Unexpectedly, Experiment 2 provided no evidence that participants made new predictions from a repaired verb. Experiment 3 provided novel findings that fixations towards the speaker increase upon hearing a hesitation, supporting current theories of how hesitations influence sentence processing. Together, these findings unpack listeners’ use of visual (objects/speaker) and auditory (speech/disfluencies) information when predicting upcoming words.

Abstract

Recent studies have detailed a remarkable degree of genetic and linguistic diversity in Northern Island Melanesia. Here we utilize that diversity to examine two models of genetic and linguistic coevolution. The first model predicts that genetic and linguistic correspondences formed following population splits and isolation at the time of early range expansions into the region. The second is analogous to the genetic model of isolation by distance, and it predicts that genetic and linguistic correspondences formed through continuing genetic and linguistic exchange between neighboring populations. We tested the predictions of the two models by comparing observed and simulated patterns of genetic variation, genetic and linguistic trees, and matrices of genetic, linguistic, and geographic distances. The data consist of 751 autosomal microsatellites and 108 structural linguistic features collected from 33 Northern Island Melanesian populations. The results of the tests indicate that linguistic and genetic exchange have erased any evidence of a splitting and isolation process that might have occurred early in the settlement history of the region. The correlation patterns are also inconsistent with the predictions of the isolation by distance coevolutionary process in the larger Northern Island Melanesian region, but there is strong evidence for the process in the rugged interior of the largest island in the region (New Britain). There we found some of the strongest recorded correlations between genetic, linguistic, and geographic distances. We also found that, throughout the region, linguistic features have generally been less likely to diffuse across population boundaries than genes. The results from our study, based on exceptionally fine-grained data, show that local genetic and linguistic exchange are likely to obscure evidence of the early history of a region, and that language barriers do not particularly hinder genetic exchange. In contrast, global patterns may emphasize more ancient demographic events, including population splits associated with the early colonization of major world regions.

Abstract

Being ostracized or excluded, even briefly and by strangers, is painful and threatens fundamental needs. Recent work by Zhong and Leonardelli (2008) found that excluded individuals perceive the room as cooler and that they desire warmer drinks. A perspective that many rely on in embodiment is the theoretical idea that people use metaphorical associations to understand social exclusion (see Landau, Meier, & Keefer, 2010). We suggest that people feel colder because they are colder. The results strongly support the idea that more complex metaphorical understandings of social relations are scaffolded onto literal changes in bodily temperature: Being excluded in an online ball tossing game leads to lower finger temperatures (Study 1), while the negative affect typically experienced after such social exclusion is alleviated after holding a cup of warm tea (Study 2). The authors discuss further implications for the interaction between body and social relations specifically, and for basic and cognitive systems in general.

Abstract

During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 × 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 × 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 × 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 × 10(-3) for 6q22 and 1.2 × 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.

Abstract

Time is a fundamental aspect of human cognition and action. All languages have developed rich means to express various facets of time, such as bare time spans, their position on the time line, or their duration. The articles in this volume give an overview of what we know about the neural and cognitive representations of time that speakers can draw on in language. Starting with an overview of the main devices used to encode time in natural language, such as lexical elements, tense and aspect, the research presented in this volume addresses the relationship between temporal language, culture, and thought, the relationship between verb aspect and mental simulations of events, the development of temporal concepts, time perception, the storage and retrieval of temporal information in autobiographical memory, and neural correlates of tense processing and sequence planning. The psychological and neurobiological findings presented here will provide important insights to inform and extend current studies of time in language and in language acquisition.

Abstract

Infectious diseases exert a constant evolutionary pressure on the innate immunity genes. TLR4, an important member of the Toll-like receptors family, specifically recognizes conserved structures of various infectious pathogens. Two functional TLR4 polymorphisms, Asp299Gly and Thr399Ile, modulate innate host defense against infections, and their prevalence between various populations has been proposed to be influenced by local infectious pressures. If this assumption is true, strong local infectious pressures would lead to a homogeneous pattern of these ancient TLR4 polymorphisms in geographically close populations, while a weak selection or genetic drift may result in a diverse pattern. We evaluated TLR4 polymorphisms in 15 ethnic groups of Iran, to assess whether infections exerted selective pressures on different haplotypes containing these variants. The Iranian subpopulations displayed a heterogeneous pattern of TLR4 polymorphisms, comprising various percentages of Asp299Gly and Thr399Ile alone or in combination. The Iranian sample as a whole showed an intermediate mixed pattern when compared with commonly found patterns in Africa, Europe, Eastern Asia and Americas. These findings suggest a weak or absent selection pressure on TLR4 polymorphisms in the Middle-East, that does not support the assumption of an important role of these polymorphisms in the host defence against local pathogens.

Abstract

How individuals learn complex regularities in the environment and generalize them to new instances is a key question in cognitive science. Although previous investigations have advocated the idea that learning and generalizing depend upon separate processes, the same basic learning mechanisms may account for both. In language learning experiments, these mechanisms have typically been studied in isolation of broader cognitive phenomena such as memory, perception, and attention. Here, we show how learning and generalization in language is embedded in these broader theories by testing learners on their ability to chunk nonadjacent dependencies—a key structure in language but a challenge to theories that posit learning through the memorization of structure. In two studies, adult participants were trained and tested on an artificial language containing nonadjacent syllable dependencies, using a novel chunking-based serial recall task involving verbal repetition of target sequences (formed from learned strings) and scrambled foils. Participants recalled significantly more syllables, bigrams, trigrams, and nonadjacent dependencies from sequences conforming to the language’s statistics (both learned and generalized sequences). They also encoded and generalized specific nonadjacent chunk information. These results suggest that participants chunk remote dependencies and rapidly generalize this information to novel structures. The results thus provide further support for learning-based approaches to language acquisition, and link statistical learning to broader cognitive mechanisms of memory.

Abstract

Hereditary mixed polyposis syndrome (HMPS) is characterized by apparent autosomal dominant inheritance of multiple types of colorectal polyp, with colorectal carcinoma occurring in a high proportion of affected individuals. Here, we use genetic mapping, copy-number analysis, exclusion of mutations by high-throughput sequencing, gene expression analysis and functional assays to show that HMPS is caused by a duplication spanning the 3' end of the SCG5 gene and a region upstream of the GREM1 locus. This unusual mutation is associated with increased allele-specific GREM1 expression. Whereas GREM1 is expressed in intestinal subepithelial myofibroblasts in controls, GREM1 is predominantly expressed in the epithelium of the large bowel in individuals with HMPS. The HMPS duplication contains predicted enhancer elements; some of these interact with the GREM1 promoter and can drive gene expression in vitro. Increased GREM1 expression is predicted to cause reduced bone morphogenetic protein (BMP) pathway activity, a mechanism that also underlies tumorigenesis in juvenile polyposis of the large bowel.

Abstract

In this study, older adults monitored for pre-assigned target sounds in a target talker's speech in a quiet (no noise) condition and in a condition with competing-talker noise. The question was to which extent the impact of the competing-talker noise on performance could be predicted from individual hearing loss and from a cognitive measure of inhibitory abilities, i.e., a measure of Stroop interference. The results showed that the non-auditory measure of Stroop interference predicted the impact of distraction on performance, over and above the effect of hearing loss. This suggests that individual differences in inhibitory abilities among older adults relate to susceptibility to distracting speech.

Abstract

Microarrays provide a powerful analytical tool for the simultaneous detection of multiple pathogens. We developed diagnostic suspension microarrays for sensitive and specific detection of the biothreat pathogens Bacillus anthracis, Yersinia pestis, Francisella tularensis and Coxiella burnetii. Two assay chemistries for amplification and labeling were developed, one method using direct hybridization and the other using target-specific primer extension, combined with hybridization to universal arrays. Asymmetric PCR products for both assay chemistries were produced by using a multiplex asymmetric PCR amplifying 16 DNA signatures (16-plex). The performances of both assay chemistries were compared and their advantages and disadvantages are discussed. The developed microarrays detected multiple signature sequences and an internal control which made it possible to confidently identify the targeted pathogens and assess their virulence potential. The microarrays were highly specific and detected various strains of the targeted pathogens. Detection limits for the different pathogen signatures were similar or slightly higher compared to real-time PCR. Probit analysis showed that even a few genomic copies could be detected with 95% confidence. The microarrays detected DNA from different pathogens mixed in different ratios and from spiked or naturally contaminated samples. The assays that were developed have a potential for application in surveillance and diagnostics. © 2012 Janse et al.

Abstract

Two studies were carried out to investigate the effects of presentation of primes showing partial (word-initial) or full overlap on processing of spoken target words. The first study investigated whether time compression would interfere with lexical processing so as to elicit aphasic-like performance in non-brain-damaged subjects. The second study was designed to compare effects of item overlap and item repetition in aphasic patients of different diagnostic types. Time compression did not interfere with lexical deactivation for the non-brain-damaged subjects. Furthermore, all aphasic patients showed immediate inhibition of co-activated candidates. These combined results show that deactivation is a fast process. Repetition effects, however, seem to arise only at the longer term in aphasic patients. Importantly, poor performance on diagnostic verbal STM tasks was shown to be related to lexical decision performance in both overlap and repetition conditions, which suggests a common underlying deficit.

Abstract

We investigated comprehension of and adaptation to speech in an unfamiliar accent in older adults. Participants performed a speeded sentence verification task for accented sentences: one group upon auditory-only presentation, and the other group upon audiovisual presentation. Our questions were whether audiovisual presentation would facilitate adaptation to the novel accent, and which cognitive and linguistic measures would predict adaptation. Participants were therefore tested on a range of background tests: hearing acuity, auditory verbal short-term memory, working memory, attention-switching control, selective attention, and vocabulary knowledge. Both auditory-only and audiovisual groups showed improved accuracy and decreasing response times over the course of the experiment, effectively showing accent adaptation. Even though the total amount of improvement was similar for the auditory-only and audiovisual groups, initial rate of adaptation was faster in the audiovisual group. Hearing sensitivity and short-term and working memory measures were associated with efficient processing of the novel accent. Analysis of the relationship between accent comprehension and the background tests revealed furthermore that selective attention and vocabulary size predicted the amount of adaptation over the course of the experiment. These results suggest that vocabulary knowledge and attentional abilities facilitate the attention-shifting strategies proposed to be required for perceptual learning.

Abstract

Rhythmic stimulation can be applied to modulate neuronal oscillations. Such ‘entrainment’ is optimized when stimulation frequency is individually calibrated based on magneto/encephalography markers. It remains unknown how consistent such individual markers are across days/sessions, within a session, or across cognitive states, hemispheres and estimation methods, especially in a realistic, practical, lab setting. We here estimated individual alpha frequency (IAF) repeatedly from short electroencephalography (EEG) measurements at rest or during an attention task (cognitive state), using single parieto-occipital electrodes in 24 participants on 4 days (between-sessions), with multiple measurements over an hour on 1 day (within-session). First, we introduce an algorithm to automatically reject power spectra without a sufficiently clear peak to ensure unbiased IAF estimations. Then we estimated IAF via the traditional ‘maximum’ method and a ‘Gaussian fit’ method. IAF was reliable within- and between-sessions for both cognitive states and hemispheres, though task-IAF estimates tended to be more variable. Overall, the ‘Gaussian fit’ method was more reliable than the ‘maximum’ method. Furthermore, we evaluated how far from an approximated ‘true’ task-related IAF the selected ‘stimulation frequency’ was, when calibrating this frequency based on a short rest-EEG, a short task-EEG, or simply selecting 10 Hz for all participants. For the ‘maximum’ method, rest-EEG calibration was best, followed by task-EEG, and then 10 Hz. For the ‘Gaussian fit’ method, rest-EEG and task-EEG-based calibration were similarly accurate, and better than 10 Hz. These results lead to concrete recommendations about valid, and automated, estimation of individual oscillation markers in experimental and clinical settings.

Abstract

Transcranial alternating current stimulation (tACS) can be used to study causal contributions of oscillatory brain mechanisms to cognition and behavior. For instance, individual alpha frequency (IAF) tACS was reported to enhance alpha power and impact visuospatial attention performance. Unfortunately, such results have been inconsistent and difficult to replicate. In tACS, stimulation generally involves one frequency, sometimes individually calibrated to a peak value observed in an M/EEG power spectrum. Yet, the ‘peak’ actually observed in such power spectra often contains a broader range of frequencies, raising the question whether a biologically calibrated tACS protocol containing this fuller range of alpha-band frequencies might be more effective. Here, we introduce ‘Broadband-alpha-tACS’, a complex individually calibrated electrical stimulation protocol. We band-pass filtered left posterior resting-state EEG data around the IAF (+/- 2 Hz), and converted that time series into an electrical waveform for tACS stimulation of that same left posterior parietal cortex location. In other words, we stimulated a brain region with a ‘replay’ of its own alpha-band frequency content, based on spontaneous activity. Within-subjects (N=24), we compared to a sham tACS session the effects of broadband-alpha tACS, power-matched spectral inverse (‘alpha-removed’) control tACS, and individual alpha frequency tACS, on EEG alpha power and performance in an endogenous attention task previously reported to be affected by alpha tACS. Broadband-alpha-tACS significantly modulated attention task performance (i.e., reduced the rightward visuospatial attention bias in trials without distractors, and reduced attention benefits). Alpha-removed tACS also reduced the rightward visuospatial attention bias. IAF-tACS did not significantly modulate attention task performance compared to sham tACS, but also did not statistically significantly differ from broadband-alpha-tACS. This new broadband-alpha tACS approach seems promising, but should be further explored and validated in future studies.

Abstract

Landmarks play an important role in successful navigation. To successfully find your way around an environment, navigationally relevant information needs to be stored and become available at later moments in time. Evidence from functional magnetic resonance imaging (fMRI) studies shows that the human parahippocampal gyrus encodes the navigational relevance of landmarks. In the present event-related fMRI experiment, we investigated memory consolidation of navigationally relevant landmarks in the medial temporal lobe after route learning. Sixteen right-handed volunteers viewed two film sequences through a virtual museum with objects placed at locations relevant (decision points) or irrelevant (nondecision points) for navigation. To investigate consolidation effects, one film sequence was seen in the evening before scanning, the other one was seen the following morning, directly before scanning. Event-related fMRI data were acquired during an object recognition task. Participants decided whether they had seen the objects in the previously shown films. After scanning, participants answered standardized questions about their navigational skills, and were divided into groups of good and bad navigators, based on their scores. An effect of memory consolidation was obtained in the hippocampus: Objects that were seen the evening before scanning (remote objects) elicited more activity than objects seen directly before scanning (recent objects). This increase in activity in bilateral hippocampus for remote objects was observed in good navigators only. In addition, a spatial-specific effect of memory consolidation for navigationally relevant objects was observed in the parahippocampal gyrus. Remote decision point objects induced increased activity as compared with recent decision point objects, again in good navigators only. The results provide initial evidence for a connection between memory consolidation and navigational ability that can provide a basis for successful navigation.

Abstract

This functional magnetic resonance imaging (fMRI) study investigates a crucial parameter in spatial description, namely variants in the frame of reference chosen. Two frames of reference are available in European languages for the description of small-scale assemblages, namely the intrinsic (or object-oriented) frame and the relative (or egocentric) frame. We showed participants a sentence such as “the ball is in front of the man”, ambiguous between the two frames, and then a picture of a scene with a ball and a man – participants had to respond by indicating whether the picture did or did not match the sentence. There were two blocks, in which we induced each frame of reference by feedback. Thus for the crucial test items, participants saw exactly the same sentence and the same picture but now from one perspective, now the other. Using this method, we were able to precisely pinpoint the pattern of neural activation associated with each linguistic interpretation of the ambiguity, while holding the perceptual stimuli constant. Increased brain activity in bilateral parahippocampal gyrus was associated with the intrinsic frame of reference whereas increased activity in the right superior frontal gyrus and in the parietal lobe was observed for the relative frame of reference. The study is among the few to show a distinctive pattern of neural activation for an abstract yet specific semantic parameter in language. It shows with special clarity the nature of the neural substrate supporting each frame of spatial reference

Abstract

A foundational assumption of human communication is that speakers should say as much as necessary, but no more. Yet, people routinely produce redundant adjectives and their propensity to do so varies cross-linguistically. Here, we propose a computational theory, whereby speakers create referential expressions designed to facilitate listeners’ reference resolution, as they process words in real time. We present a computational model of our account, the Incremental Collaborative Efficiency (ICE) model, which generates referential expressions by considering listeners’ real-time incremental processing and reference identification. We apply the ICE framework to physical reference, showing that listeners construct expressions designed to minimize listeners’ expected visual search effort during online language processing. Our model captures a number of known effects in the literature, including cross-linguistic differences in speakers’ propensity to over-specify. Moreover, the ICE model predicts graded acceptability judgments with quantitative accuracy, systematically outperforming an alternative, brevity-based model. Our findings suggest that physical reference production is best understood as driven by a collaborative goal to help the listener identify the intended referent, rather than by an egocentric effort to minimize utterance length.

Abstract

The QWERTY keyboard mediates communication for millions of language users. Here, we investigated whether differences in the way words are typed correspond to differences in their meanings. Some words are spelled with more letters on the right side of the keyboard and others with more letters on the left. In three experiments, we tested whether asymmetries in the way people interact with keys on the right and left of the keyboard influence their evaluations of the emotional valence of the words. We found the predicted relationship between emotional valence and QWERTY key position across three languages (English, Spanish, and Dutch). Words with more right-side letters were rated as more positive in valence, on average, than words with more left-side letters: the QWERTY effect. This effect was strongest in new words coined after QWERTY was invented and was also found in pseudowords. Although these data are correlational, the discovery of a similar pattern across languages, which was strongest in neologisms, suggests that the QWERTY keyboard is shaping the meanings of words as people filter language through their fingers. Widespread typing introduces a new mechanism by which semanntic changes in language can arise.

Abstract

Curiosity is one of the most basic biological drives in both animals and humans, and has been identified as a key motive for learning and discovery. Despite the importance of curiosity and related behaviors, the topic has been largely neglected in human neuroscience; hence little is known about the neurobiological mechanisms underlying curiosity. We used functional magnetic resonance imaging (fMRI) to investigate what happens in our brain during the induction and subsequent relief of perceptual curiosity. Our core findings were that (1) the induction of perceptual curiosity, through the presentation of ambiguous visual input, activated the anterior insula and anterior cingulate cortex (ACC), brain regions sensitive to conflict and arousal; (2) the relief of perceptual curiosity, through visual disambiguation, activated regions of the striatum that have been related to reward processing; and (3) the relief of perceptual curiosity was associated with hippocampal activation and enhanced incidental memory. These findings provide the first demonstration of the neural basis of human perceptual curiosity. Our results provide neurobiological support for a classic psychological theory of curiosity, which holds that curiosity is an aversive condition of increased arousal whose termination is rewarding and facilitates memory.

Abstract

Older listeners are more affected than younger listeners in their recognition of speech in adverse conditions, such as when they also hear a single-competing speaker. In the present study, we investigated with a speeded response task whether older listeners with various degrees of hearing loss benefit under such conditions from also seeing the speaker they intend to listen to. We also tested, at the same time, whether older adults need postperceptual processing to obtain an audiovisual benefit. When tested in a phoneme-monitoring task with single-talker noise present, older (and younger) listeners detected target phonemes more reliably and more rapidly in meaningful sentences uttered by the target speaker when they also saw the target speaker. This suggests that older adults processed audiovisual speech rapidly and efficiently enough to benefit already during spoken sentence processing. Audiovisual benefits for older adults were similar in size to those observed for younger adults in terms of response latencies, but smaller for detection accuracy. Older adults with more hearing loss showed larger audiovisual benefits. Attentional abilities predicted the size of audiovisual response time benefits in both age groups. Audiovisual benefits were found in both age groups when monitoring for the visually highly distinct phoneme /p/ and when monitoring for the visually less distinct phoneme /k/. Visual speech thus provides segmental information about the target phoneme, but also provides more global contextual information that helps both older and younger adults in this adverse listening situation.

Abstract

Using a referent detection paradigm, we examined whether listeners can determine the object speakers are referring to by using the temporal alignment between the motion speakers impose on objects and their labeling utterances. Stimuli were created by videotaping speakers labeling a novel creature. Without being explicitly instructed to do so, speakers moved the creature during labeling. Trajectories of these motions were used to animate photographs of the creature. Participants in subsequent perception studies heard these labeling utterances while seeing side-by-side animations of two identical creatures in which only the target creature moved as originally intended by the speaker. Using the cross-modal temporal relationship between speech and referent motion, participants identified which creature the speaker was labeling, even when the labeling utterances were low-pass filtered to remove their semantic content or replaced by tone analogues. However, when the prosodic structure was eliminated by reversing the speech signal, participants no longer detected the referent as readily. These results provide strong support for a prosodic cross-modal alignment hypothesis. Speakers produce a perceptible link between the motion they impose upon a referent and the prosodic structure of their speech, and listeners readily use this prosodic cross-modal relationship to resolve referential ambiguity in word-learning situations.

Abstract

Language sometimes requires tracking the same participant in different thematic roles across multiple visual events (e.g., The girl that another girl pushed chased a third girl). To better understand how vision and language interact in role tracking, participants described videos of multiple randomly moving circles where two push events were presented. A circle might have the same role in both push events (e.g., agent) or different roles (e.g., agent of one push and patient of other push). The first three studies found higher production accuracy for the same role conditions compared to the different role conditions across different linguistic structure manipulations. The last three studies compared a featural account, where role information was associated with particular circles, or a relational account, where role information was encoded with particular push events. These studies found no interference between different roles, contrary to the predictions of the featural account. The foil was manipulated in these studies to increase the saliency of the second push and it was found that this changed the accuracy in describing the first push. The results suggest that language-related thematic role processing uses a relational representation that can encode multiple events.

Abstract

Although the human brain may have evolutionarily adapted to face-to-face communication, other modes of communication, e.g., telephone and e-mail, increasingly dominate our modern daily life. This study examined the neural difference between face-to-face communication and other types of communication by simultaneously measuring two brains using a hyperscanning approach. The results showed a significant increase in the neural synchronization in the left inferior frontal cortex during a face-to-face dialog between partners but none during a back-to-back dialog, a face-to-face monologue, or a back-to-back monologue. Moreover, the neural synchronization between partners during the face-to-face dialog resulted primarily from the direct interactions between the partners, including multimodal sensory information integration and turn-taking behavior. The communicating behavior during the face-to-face dialog could be predicted accurately based on the neural synchronization level. These results suggest that face-to-face communication, particularly dialog, has special neural features that other types of communication do not have and that the neural synchronization between partners may underlie successful face-to-face communication.

Abstract

Each clause and phrase boundary necessarily aligns with a word boundary. Thus, infants’ attention to the edges of clauses and phrases may help them learn some of the language-specific cues defining word boundaries. Attention to prosodically wellformed clauses and phrases may also help infants begin to extract information important for learning the grammatical structure of their language. Despite the potentially important role that the perception of large prosodic units may play in early language acquisition, there has been little work investigating the extraction of these units from fluent speech by infants learning languages other than English. We report 2 experiments investigating Dutch learners’ clause segmentation abilities.In these studies, Dutch-learning 6-month-olds readily extract clauses from speech. However, Dutch learners differ from English learners in that they seem to be more reliant on pauses to detect clause boundaries. Two closely related explanations for this finding are considered, both of which stem from the acoustic differences in clause boundary realizations in Dutch versus English.

Abstract

Research on spontaneous language acquisition both in children learning their mother tongue and in adults learning a second language has shown that language development proceeds in a stagewise manner. Learner utterances are accounted for in terms of so-called 'learner languages'. Learner languages of both children and adults are language systems that are initially rather simple. The present monograph shows how these learner languages develop both in child L1 and in adult L2 Dutch. At the initial stage of both L1 and L2 Dutch, learner systems are lexical systems. This means that utterance structure is determined by the lexical projection of a predicate-argument structure, while the functional properties of the target language are absent. At some point in acquisition, this lexical-semantic system develops into a target-like system. With this target-like system, learners have reached a stage at which their language system has the morpho-syntactic features to express the functional properties of finiteness and topicality. Evidence of this is word order variation and the use of linguistic elements such as auxiliaries, tense, and agreement markers and determiners. Looking at this process of language acquisition from a functional point of view, the author focuses on questions such as the following. What is the driving force behind the process that causes learners to give up a simple lexical-semantic system in favour of a functional-pragmatic one? What is the added value of linguistic features such as the morpho-syntactic properties of inflection, word order variation, and definiteness?

Abstract

Around their first birthday infants begin to talk, yet they comprehend words long before. This study investigated the event-related potentials (ERP) responses of nine-month-olds on basic level picture-word pairings. After a familiarization phase of six picture-word pairings per semantic category, comprehension for novel exemplars was tested in a picture-word matching paradigm. ERPs time-locked to pictures elicited a modulation of the Negative Central (Nc) component, associated with visual attention and recognition. It was attenuated by category repetition as well as by the type-token ratio of picture context. ERPs time-locked to words in the training phase became more negative with repetition (N300-600), but there was no influence of picture type-token ratio, suggesting that infants have identified the concept of each picture before a word was presented. Results from the test phase provided clear support that infants integrated word meanings with (novel) picture context. Here, infants showed different ERP responses for words that did or did not align with the picture context: a phonological mismatch (N200) and a semantic mismatch (N400). Together, results were informative of visual categorization, word recognition and word-to-world-mappings, all three crucial processes for vocabulary construction.

Abstract

Infants’ ability to recognize words in continuous speech is vital for building a vocabulary.We here examined the amount and type
of exposure needed for 10-month-olds to recognize words. Infants first heard a word, either embedded within an utterance or in
isolation, then recognition was assessed by comparing event-related potentials to this word versus a word that they had not heard
directly before. Although all 10-month-olds showed recognition responses to words first heard in isolation, not all infants showed
such responses to words they had first heard within an utterance. Those that did succeed in the latter, harder, task, however,
understood more words and utterances when re-tested at 12 months, and understood more words and produced more words at
24 months, compared with those who had shown no such recognition response at 10 months. The ability to rapidly recognize the
words in continuous utterances is clearly linked to future language development.

Abstract

Expressing Left-Right relations is challenging for speaking-children. Yet, this challenge was absent for signing-children, possibly due to iconicity in the visual-spatial modality of expression. We investigate whether there is also a modality advantage when speaking-children’s co-speech gestures are considered. Eight-year-old child and adult hearing monolingual Turkish speakers and deaf signers of Turkish-Sign-Language described pictures of objects in various spatial relations. Descriptions were coded for informativeness in speech, sign, and speech-gesture combinations for encoding Left-Right relations. The use of co-speech gestures increased the informativeness of speakers’ spatial expressions compared to speech-only. This pattern was more prominent for children than adults. However, signing-adults and children were more informative than child and adult speakers even when co-speech gestures were considered. Thus, both speaking- and signing-children benefit from iconic expressions in visual modality. Finally, in each modality, children were less informative than adults, pointing to the challenge of this spatial domain in development.

Abstract

Oral communication often takes place in noisy environments, which challenge spoken-word recognition. Previous research has suggested that the presence of background noise extends the number of candidate words competing with the target word for recognition and that this extension affects the time course and accuracy of spoken-word recognition. In this study, we further investigated the temporal dynamics of competition processes in the presence of background noise, and how these vary in listeners with different language proficiency (i.e., native and non-native) using computational modeling. We developed ListenIN (Listen-In-Noise), a neural-network model based on an autoencoder architecture, which learns to map phonological forms onto meanings in two languages and simulates native and non-native spoken-word comprehension. Simulation A established that ListenIN captures the effects of noise on accuracy rates and the number of unique misperception errors of native and non-native listeners in an offline spoken-word identification task (Scharenborg et al., 2018). Simulation B showed that ListenIN captures the effects of noise in online task settings and accounts for looking preferences of native (Hintz & Scharenborg, 2016) and non-native (new data collected for this study) listeners in a visual-world paradigm. We also examined the model’s activation states during online spoken-word recognition. These analyses demonstrated that the presence of background noise increases the number of competitor words which are engaged in phonological competition and that this happens in similar ways intra- and interlinguistically and in native and non-native listening. Taken together, our results support accounts positing a ‘many-additional-competitors scenario’ for the effects of noise on spoken-word recognition.

Abstract

Developmental stuttering is a fluency disorder that adversely affect many aspects of a person's life. Recent transcranial direct current stimulation (tDCS) studies have shown promise to improve fluency in people who stutter. To date, bihemispheric tDCS has not been investigated in this population. In the present study, we aimed to investigate the effects of single-session bihemispheric and unihemispheric cathodal tDCS on fluency in adults who stutter. We predicted that bihemispheric tDCS with anodal stimulation to the left IFG and cathodal stimulation to the right IFG would improve fluency better than the sham and cathodal tDCS to the right IFG. Seventeen adults who stutter completed this single-blind, crossover, sham-controlled tDCS experiment. All participants received 20 min of tDCS alongside metronome-timed speech during intervention sessions. Three tDCS interventions were administered: bihemispheric tDCS with anodal stimulation to the left IFG and cathodal stimulation to the right IFG, unihemispheric tDCS with cathodal stimulation to the right IFG, and sham stimulation. Speech fluency during reading and conversation was assessed before, immediately after, and one week after each intervention session. There was no significant fluency improvement in conversation for any tDCS interventions. Reading fluency improved following both bihemispheric and cathodal tDCS interventions. tDCS montages were not significantly different in their effects on fluency.

Abstract

The COVID-19 pandemic, and the resulting closure of daycare centers worldwide, led to unprecedented changes in children’s learning environments. This period of increased time at home with caregivers, with limited access to external sources (e.g., daycares) provides a unique opportunity to examine the associations between the caregiver-child activities and children’s language development. The vocabularies of 1742 children aged8-36 months across 13 countries and 12 languages were evaluated at the beginning and end of the first lockdown period in their respective countries(from March to September 2020). Children who had less passive screen exposure and whose caregivers read more to them showed larger gains in vocabulary development during lockdown, after controlling for SES and other caregiver-child activities. Children also gained more words than expected (based on normative data) during lockdown; either caregivers were more aware of their child’s development or vocabulary development benefited from intense caregiver-child interaction during lockdown.

Abstract

Hand gestures combine with speech to form a single integrated system of meaning during language comprehension (Kelly et al., 2010). However, it is unknown whether gesture is uniquely integrated with speech or is processed like any other manual action. Thirty-one participants watched videos presenting speech with gestures or manual actions on objects. The relationship between the speech and gesture/action was either complementary (e.g., “He found the answer,” while producing a calculating gesture vs. actually using a calculator) or incongruent (e.g., the same sentence paired with the incongruent gesture/action of stirring with a spoon). Participants watched the video (prime) and then responded to a written word (target) that was or was not spoken in the video prime (e.g., “found” or “cut”). ERPs were taken to the primes (time-locked to the spoken verb, e.g., “found”) and the written targets. For primes, there was a larger frontal N400 (semantic processing) to incongruent vs. congruent items for the gesture, but not action, condition. For targets, the P2 (phonemic processing) was smaller for target words following congruent vs. incongruent gesture, but not action, primes. These findings suggest that hand gestures are integrated with speech in a privileged fashion compared to manual actions on objects.

Abstract

Transcranial alternating current stimulation (tACS) at 10 Hz has been shown to modulate spatial attention. However, the frequency-specificity and the oscillatory changes underlying this tACS effect are still largely unclear. Here, we applied high-definition tACS at individual alpha frequency (IAF), two control frequencies (IAF+/-2Hz) and sham to the left posterior parietal cortex and measured its effects on visuospatial attention performance and offline alpha power (using electroencephalography, EEG). We revealed a behavioural and electrophysiological stimulation effect relative to sham for IAF but not control frequency stimulation conditions: there was a leftward lateralization of alpha power for IAF tACS, which differed from sham for the first out of three minutes following tACS. At a high value of this EEG effect (moderation effect), we observed a leftward attention bias relative to sham. This effect was task-specific, i.e., it could be found in an endogenous attention but not in a detection task. Only in the IAF tACS condition, we also found a correlation between the magnitude of the alpha lateralization and the attentional bias effect. Our results support a functional role of alpha oscillations in visuospatial attention and the potential of tACS to modulate it. The frequency-specificity of the effects suggests that an individualization of the stimulation frequency is necessary in heterogeneous target groups with a large variation in IAF.

Abstract

Visuospatial attention can either be voluntarily directed (endogenous/top-down attention) or automatically triggered (exogenous/bottom-up attention). Recent research showed that dorsal parietal transcranial alternating current stimulation (tACS) at alpha frequency modulates the spatial attentional bias in an endogenous but not in an exogenous visuospatial attention task. Yet, the reason for this task-specificity remains unexplored. Here, we tested whether this dissociation relates to the proposed differential role of the dorsal attention network (DAN) and ventral attention network (VAN) in endogenous and exogenous attention processes respectively. To that aim, we targeted the left and right dorsal parietal node of the DAN, as well as the left and right ventral temporoparietal node of the VAN using tACS at the individual alpha frequency. Every participant completed all four stimulation conditions and a sham condition in five separate sessions. During tACS, we assessed the behavioral visuospatial attention bias via an endogenous and exogenous visuospatial attention task. Additionally, we measured offline alpha power immediately before and after tACS using electroencephalography (EEG). The behavioral data revealed an effect of tACS on the endogenous but not exogenous attention bias, with a greater leftward bias during (sham-corrected) left than right hemispheric stimulation. In line with our hypothesis, this effect was brain area-specific, i.e., present for dorsal parietal but not ventral temporoparietal tACS. However, contrary to our expectations, there was no effect of ventral temporoparietal tACS on the exogenous visuospatial attention bias. Hence, no double dissociation between the two targeted attention networks. There was no effect of either tACS condition on offline alpha power. Our behavioral data reveal that dorsal parietal but not ventral temporoparietal alpha oscillations steer endogenous visuospatial attention. This brain-area specific tACS effect matches the previously proposed dissociation between the DAN and VAN and, by showing that the spatial attention bias effect does not generalize to any lateral posterior tACS montage, renders lateral cutaneous and retinal effects for the spatial attention bias in the dorsal parietal condition unlikely. Yet the absence of tACS effects on the exogenous attention task suggests that ventral temporoparietal alpha oscillations are not functionally relevant for exogenous visuospatial attention. We discuss the potential implications of this finding in the context of an emerging theory on the role of the ventral temporoparietal node.

Abstract

When you compare the behavior of two different age groups which are trying to master the same sensori-motor or cognitive skill, you are likely to discover varying learning routes: different stages, different intervals between stages, or even different orderings of stages. Such heterogeneous learning trajectories may be caused by at least six different types of factors: (1) Initial state: the kinds and levels of skills the learners have available at the onset of the learning episode. (2) Learning mechanisms: rule-based, inductive, connectionist, parameter setting, and so on. (3) Input and feedback characteristics: learning stimuli, information about success and failure. (4) Information processing mechanisms: capacity limitations, attentional biases, response preferences. (5) Energetic variables: motivation, emotional reactions. (6) Final state: the fine-structure of kinds and levels of subskills at the end of the learning episode. This applies to language acquisition as well. First and second language learners probably differ on all six factors. Nevertheless, the debate between advocates and opponents of the Fundamental Difference Hypothesis concerning L1 and L2 acquisition have looked almost exclusively at the first two factors. Those who believe that L1 learners have access to Universal Grammar whereas L2 learners rely on language processing strategies, postulate different learning mechanisms (UG parameter setting in L1, more general inductive strategies in L2 learning). Pienemann opposes this view and, based on his Processability Theory, argues that L1 and L2 learners start out from different initial states: they come to the grammar learning task with different structural hypotheses (SOV versus SVO as basic word order of German).

Abstract

Grammatical encoding and grammatical decoding (in sentence production and comprehension, respectively) are often portrayed as independent modalities of grammatical performance that only share declarative resources: lexicon and grammar. The processing resources subserving these modalities are supposed to be distinct. In particular, one assumes the existence of two workspaces where grammatical structures are assembled and temporarily maintained—one for each modality. An alternative theory holds that the two modalities share many of their processing resources and postulates a single mechanism for the online assemblage and short-term storage of grammatical structures: a shared workspace. We report two experiments with a novel “grammatical multitasking” paradigm: the participants had to read (i.e., decode) and to paraphrase (encode) sentences presented in fragments, responding to each input fragment as fast as possible with a fragment of the paraphrase. The main finding was that grammatical constraints with respect to upcoming input that emanate from decoded sentence fragments are immediately replaced by grammatical expectations emanating from the structure of the corresponding paraphrase fragments. This evidences that the two modalities have direct access to, and operate upon, the same (i.e., token-identical) grammatical structures. This is possible only if the grammatical encoding and decoding processes command the same, shared grammatical workspace. Theoretical implications for important forms of grammatical multitasking—self-monitoring, turn-taking in dialogue, speech shadowing, and simultaneous translation—are explored.

Abstract

A series of experiments is reported in which subjects describe simple visual scenes by means of both sentential and non-sentential responses. The data support the following statements about the lexicalization (word finding) process. (1) Words used by speakers in overt naming or sentence production responses are selected by a sequence of two lexical retrieval processes, the first yielding abstract pre-phonological items (Ll -items), the second one adding their phonological shapes (L2-items). (2) The selection of several Ll-items for a multi-word utterance can take place simultaneously. (3) A monitoring process is watching the output of Ll-lexicalization to check if it is in keeping with prevailing constraints upon utterance format. (4) Retrieval of the L2-item which corresponds with a given LI-item waits until the Ld-item has been checked by the monitor, and all other Ll-items needed for the utterance under construction have become available. A coherent picture of the lexicalization process begins to emerge when these characteristics are brought together with other empirical results in the area of naming and sentence production, e.g., picture naming reaction times (Seymour, 1979), speech errors (Garrett, 1980), and word order preferences (Bock, 1982).

Abstract

Two Event-Related Potential (ERP) studies contrast the processing of locally ambiguous sentences in the visual and the auditory modality. These sentences are disambiguated by a lexical element. Before this element appears in a sentence, the sentence can also be disambiguated by a boundary marker: a comma in the visual modality, or a prosodic break in the auditory modality. Previous studies have shown that a specific ERP component, the Closure Positive Shift (CPS), can be elicited by these markers. The results of the present studies show that both the comma and the prosodic break disambiguate the ambiguous sentences before the critical lexical element, despite the fact that a clear CPS is only found in the auditory modality. Comma and prosodic break thus have parallel functions irrespective of whether they do or do not elicit a CPS.

Abstract

Functional imaging studies have demonstrated involvement of the anterior temporal cortex in sentence comprehension. It is unclear, however, whether the anterior temporal cortex is essential for this function.We studied two aspects of sentence comprehension, namely syntactic and prosodic comprehension in temporal lobe epilepsy patients who were candidates for resection of the anterior temporal lobe. Methods: Temporal lobe epilepsy patients (n = 32) with normal (left) language dominance were tested on syntactic and prosodic comprehension before and after removal of the anterior temporal cortex. The prosodic comprehension test was also compared with performance of healthy control subjects (n = 47) before surgery. Results: Overall, temporal lobe epilepsy patients did not differ from healthy controls in syntactic and prosodic comprehension before surgery. They did perform less well on an affective prosody task. Post-operative testing revealed that syntactic and prosodic comprehension did not change after removal of the anterior temporal cortex. Discussion: The unchanged performance on syntactic and prosodic comprehension after removal of the anterior temporal cortex suggests that this area is not indispensable for sentence comprehension functions in temporal epilepsy patients. Potential implications for the postulated role of the anterior temporal lobe in the healthy brain are discussed.

Abstract

A comprehensive theory of child language acquisition requires an evidential base that is representative of the typological diversity present in the world’s 7000 or so languages. However, languages are dying at an alarming rate, and the next 50 years represents the last chance we have to document acquisition in many of them. Here, we take stock of the last 45 years of research published in the four main child language acquisition journals: Journal of Child Language, First Language, Language Acquisition and Language Learning and Development. We coded each article for several variables, including (1) participant group (mono vs multilingual), (2) language(s), (3) topic(s) and (4) country of author affiliation, from each journal’s inception until the end of 2020. We found that we have at least one article published on around 103 languages, representing approximately 1.5% of the world’s languages. The distribution of articles was highly skewed towards English and other well-studied Indo-European languages, with the majority of non-Indo-European languages having just one paper. A majority of the papers focused on studies of monolingual children, although papers did not always explicitly report participant group status. The distribution of topics across language categories was more even. The number of articles published on non-Indo-European languages from countries outside of North America and Europe is increasing; however, this increase is driven by research conducted in relatively wealthy countries. Overall, the vast majority of the research was produced in the Global North. We conclude that, despite a proud history of crosslinguistic research, the goals of the discipline need to be recalibrated before we can lay claim to truly a representative account of child language acquisition.

Abstract

Our original target article highlighted some significant shortcomings in the current state of child language research: a large skew in our evidential base towards English and a handful of other Indo-European languages that partly has its origins in a lack of researcher diversity. In this article, we respond to the 21 commentaries on our original article. The commentaries highlighted both the importance of attention to typological features of languages and the environments and contexts in which languages are acquired, with many commentators providing concrete suggestions on how we address the data skew. In this response, we synthesise the main themes of the commentaries and make suggestions for how the field can move towards both improving data coverage and opening up to traditionally under-represented researchers.

Abstract

This article reports on an individual differences study that investigated the role of implicit statistical learning in the acquisition of syntax in children. One hundred children ages 4 years 5 months through 6 years 11 months completed a test of implicit statistical learning, a test of explicit declarative learning, and standardized tests of verbal and nonverbal ability. They also completed a syntactic priming task, which provided a dynamic index of children's facility to detect and respond to changes in the input frequency of linguistic structure. The results showed that implicit statistical learning ability was directly associated with the long-term maintenance of the primed structure. The results constitute the first empirical demonstration of a direct association between implicit statistical learning and syntactic acquisition in children.

Abstract

Although the syntactic priming methodology is a promising tool for language acquisition researchers, using the technique with children raises issues that are not problematic in adult research. The current paper reports on an individual differences study that addressed some of these outstanding issues. (a) Does priming purely reflect syntactic knowledge, or are other processes involved? (b) How can we explain individual differences, which are the norm rather than the exception? (c) Do priming effects in developmental populations reflect the same mechanisms thought to be responsible for priming in adults? One hundred twenty-two (N = 122) children aged 4 years, 5 months (4;5)–6;11 (mean = 5;7) completed a syntactic priming task that aimed to prime the English passive construction, in addition to standardized tests of vocabulary, grammar, and nonverbal intelligence. The results confirmed the widely held assumption that syntactic priming reflects the presence of syntactic knowledge, but not in every instance. However, they also suggested that nonlinguistic processes contribute significantly to priming. Priming was in no way related to age. Finally, the children's linguistic knowledge and nonverbal ability determined the manner in which they were primed. The results provide a clearer picture of what it means to be primed in acquisition.

Abstract

The present article reports on an investigation of one child's acquisition of the multiple senses of the preposition with from 2;0–4;0. Two competing claims regarding children's early representation and subsequent acquisition of with were investigated. The “multiple meanings” hypothesis predicts that children form individual form-meaning pairings for with as separate lexical entries. The “monosemy approach” (McKercher 2001) claims that children apply a unitary meaning by abstracting core features early in acquisition. The child's (“Brian”) speech and his input were coded according to eight distinguishable senses of with. The results showed that Brian first acquired the senses that were most frequent in the input (accompaniment, attribute, and instrument). Less common senses took much longer to emerge. A detailed analysis of the input showed that a variety of clues are available that potentially enable the child to distinguish among high frequency senses. The acquisition data suggested that the child initially applied a restricted one-to-one form-meaning mapping for with, which is argued to reflect the spatial properties of the preposition. On the basis of these results it is argued that neither the monosemy nor the multiple meanings approach can fully explain the data, but that the results are best explained by a combination of word learning principles and children's ability to categorize the contextual properties of each sense's use in the ambient language.

Abstract

Hartshorne and Ullman (2006) presented naturalistic language data from 25 children (15 boys, 10 girls) and showed that girls produced more past tense overregularization errors than did boys. In particular, girls were more likely to overregularize irregular verbs whose stems share phonological similarities with regular verbs. It was argued that the result supported the Declarative/Procedural model of language, a neuropsychological analogue of the dual-route approach to language. In the current study we present experimental data that are inconsistent with these naturalistic data. Eighty children (40 males, 40 females) aged 5;0–6;9 completed a past tense elicitation task, a test of declarative memory, and a test of non-verbal intelligence. The results revealed no sex differences on any of the measures. Instead, the best predictors of overregularization rates were item-level features of the test verbs. We discuss the results within the context of dual versus single route debate on past tense acquisition

Abstract

To segment continuous speech into its component words, listeners make use of language rhythm; because rhythm differs across languages, so do the segmentation procedures which listeners use. For each of stress-, syllable-and mora-based rhythmic structure, perceptual experiments have led to the discovery of corresponding segmentation procedures. In the case of mora-based rhythm, similar segmentation has been demonstrated in the otherwise unrelated languages Japanese and Telugu; segmentation based on syllable rhythm, however, has been previously demonstrated only for European languages from the Romance family. We here report two target detection experiments in which Korean listeners, presented with speech in Korean and in French, displayed patterns of segmentation like those previously observed in analogous experiments with French listeners. The Korean listeners' accuracy in detecting word-initial target fragments in either language was significantly higher when the fragments corresponded exactly to a syllable in the input than when the fragments were smaller or larger than a syllable. We conclude that Korean and French listeners can call on similar procedures for segmenting speech, and we further propose that perceptual tests of speech segmentation provide a valuable accompaniment to acoustic analyses for establishing languages' rhythmic class membership.

Abstract

How do Dutch and Korean listeners use acoustic–phonetic information when learning words in an artificial language? Dutch has a voiceless ‘unaspirated’ stop, produced with shortened Voice Onset Time (VOT) in prosodic strengthening environments (e.g., in domain-initial position and under prominence), enhancing the feature {−spread glottis}; Korean has a voiceless ‘aspirated’ stop produced with lengthened VOT in similar environments, enhancing the feature {+spread glottis}. Given this cross-linguistic difference, two competing hypotheses were tested. The phonological-superiority hypothesis predicts that Dutch and Korean listeners should utilize shortened and lengthened VOTs, respectively, as cues in artificial-language segmentation. The phonetic-superiority hypothesis predicts that both groups should take advantage of the phonetic richness of longer VOTs (i.e., their enhanced auditory–perceptual robustness). Dutch and Korean listeners learned the words of an artificial language better when word-initial stops had longer VOTs than when they had shorter VOTs. It appears that language-specific phonological knowledge can be overridden by phonetic richness in processing an unfamiliar language. Listeners nonetheless performed better when the stimuli were based on the speech of their native languages, suggesting that the use of richer phonetic information was modulated by listeners' familiarity with the stimuli.

Abstract

We used event-related potentials (ERPs) to investigate the timecourse of interactions between lexical-semantic and sub-lexical visual word-form processing during word recognition. Participants read sentence-embedded pseudowords that orthographically resembled a contextually-supported real word (e.g., “She measured the flour so she could bake a ceke …”) or did not (e.g., “She measured the flour so she could bake a tont …”) along with nonword consonant strings (e.g., “She measured the flour so she could bake a srdt …”). Pseudowords that resembled a contextually-supported real word (“ceke”) elicited an enhanced positivity at 130 msec (P130), relative to real words (e.g., “She measured the flour so she could bake a cake …”). Pseudowords that did not resemble a plausible real word (“tont”) enhanced the N170 component, as did nonword consonant strings (“srdt”). The effect pattern shows that the visual word recognition system is, perhaps counterintuitively, more rapidly sensitive to minor than to flagrant deviations from contextually-predicted inputs. The findings are consistent with rapid interactions between lexical and sub-lexical representations during word recognition, in which rapid lexical access of a contextually-supported word (CAKE) provides top-down excitation of form features (“cake”), highlighting the anomaly of an unexpected word “ceke”.

Abstract

The artificial language learning paradigm was used to investigate to what extent the use of prosodic features is universally applicable or specifically language driven in learning an unfamiliar language, and how nonnative prosodic patterns can be learned. Listeners of unrelated languages—Dutch (n = 100) and Korean (n = 100)—participated. The words to be learned varied with prosodic cues: no prosody, fundamental frequency (F0) rise in initial and final position, final lengthening, and final lengthening plus F0 rise. Both listener groups performed well above chance level with the final lengthening cue, confirming its crosslinguistic use. As for final F0 rise, however, Dutch listeners did not use it until the second exposure session, whereas Korean listeners used it at initial exposure. Neither group used initial F0 rise. On the basis of these results, F0 and durational cues appear to be universal in the sense that they are used across languages for their universally applicable auditory-perceptual saliency, but how they are used is language specific and constrains the use of available prosodic cues in processing a nonnative language. A discussion on how these findings bear on theories of second language (L2) speech perception and learning is provided.

Abstract

The acquisition of the past tense has received substantial attention in the psycholinguistics literature, yet most studies report data from English or closely related Indo-European languages. We report on a past tense elicitation study on 136 4–6-year-old children that were acquiring a highly inflected Finno-Ugric (Uralic) language—Finnish. The children were tested on real and novel verbs (N = 120) exhibiting (1) productive, (2) semi-productive, or (3) non-productive inflectional processes manipulated for frequency and phonological neighbourhood density (PND). We found that Finnish children are sensitive to lemma/base frequency and PND when processing inflected words, suggesting that even though children were using suffixation processes, they were also paying attention to the item level properties of the past tense verbs. This paper contributes to the growing body of research suggesting a single analogical/associative mechanism is sufficient in processing both productive (i.e., regular-like) and non-productive (i.e., irregular-like) words. We argue that seemingly rule-like elements in inflectional morphology are an emergent property of the lexicon.

Abstract

Infant pointing has long been identified as an important precursor and predictor of language development. Infants typically begin to produce index finger pointing around the time of their first birthday and previous research has shown that both the onset and the frequency of pointing can predict aspects of productive and receptive language. The current study used a multivariate meta-analytic approach to estimate the strength of the relationship between infant pointing and language. We identified 30 papers published between 1984 and 2019 that met our stringent inclusion criteria, and 25 studies (comprising 77 effect sizes) with samples ≥10 were analysed. Methodological quality of the studies was assessed to identify potential sources of bias. We found a significant but small overall effect size of r = 0.20. Our findings indicate that the unique contribution of pointing to language development may be less robust than has been previously understood, however our stringent inclusion criteria (as well as our publication bias corrections), means that our data represent a more conservative estimate of the relationship between pointing and language. Moderator analysis showed significant group differences in favour of effect sizes related to language comprehension, non-vocabulary measures of language, pointing assessed after 18 months of age and pointing measured independent of speech. A significant strength of this study is the use of multivariate meta-analysis, which allowed us to utilise all available data to provide a more accurate estimate. We consider the findings in the context of the existing research and discuss the general limitations in this field, including the lack of cultural diversity.

Abstract

There are two core phenomena which any empirical investigation of beauty must account for: the existence of aesthetical experience, and the enormous variability of this experience across times, cultures, people. Hence, it would seem a hopeless enterprise to determine ‘the very nature’ of beauty, and in fact, none of the many attempts from the Antiquity to present days found general acceptance. But what we should be able to investigate and understand is how properties of people, for example their varying cultural experiences, are correlated with the properties of objects which we evaluate. Beauty is neither only in the eye of the observer nor only in the objects which it sees - it is in the way in which specific observers see specific objects.

Abstract

All disciplines depend on language; but two of them also have language as an object – literary studies and linguistics. Their objectives are not the same – but they are sufficiently similar to invite close cooperation. This is not what we find; in fact, the development of research over the last decades has led to a relationship which is, in the typical case, characterised by friendly, and sometimes less friendly, ignorance and indifference. This article discusses some of the reasons for this development, and it suggests some conditions under which both sides would benefit from more cooperation.

Abstract

During the last 25 years, second language acquisition (SLA) research hasmade considerable progress, but is still far from proving a solid basis for foreign language teaching, or from a general theory of SLA. In addition, its status within the linguistic disciplines is still very low. I argue this has not much to do with low empirical or theoretical standards in the field—in this regard, SLA research is fully competitive—but with a particular perspective on the acquisition process: SLA researches learners' utterances as deviations from a certain target, instead of genuine manifestations of underlying language capacity; it analyses them in terms of what they are not rather than what they are. For some purposes such a "target deviation perspective" makes sense, but it will not help SLA researchers to substantially and independently contribute to a deeper understanding of the structure and function of the human language faculty. Therefore, these findings will remain of limited interest to other scientists until SLA researchers consider learner varieties a normal, in fact typical, manifestation of this unique human capacity.

Abstract

Starting with Ross (1970), various proposals have been made to classify elliptical coordinations and to characterize different languages according to the types of ellipses which they admit. Sanders (1977) discusses four of these proposals, shows that they are inadequate on various grounds and proposes a fifth typology whose central claim is 'evidently correct', as he states (p. 258). In the following, I shall briefly outline this typology and then show that it is inadequate, too. Since there is only one language 1 know — German — I will take all my examples from this language. Moreover, all examples will be straightforward and easy to be judged.

Abstract

Widespread minority language shift in Early Modern Europe is often ascribed to restrictive language policies and the migration of both majority- and minority-language speakers. However, without a sociohistorically credible account of the mechanisms through which these events caused a language shift, these policies lack explanatory power. Inspired by research on 'language histories from below,' we present an integrated sociohistorical and linguistic account that can shed light on the procresses taking place during a case of language shift in the 17th and 18th centuries. We present and analyze demographic data on the immigration and integration of French speakers in previously Dutch-speaking Dunkirk in this period, showing how moderate intermarriage of immigrants and locals could have represented a motive and a mechanism for language shift against a backdrop of larger language-political processes. We then discuss the modern language-shift dialect of Dunkirk in comparison with different dialects of French. The linguistic data suggests a large influence from the dialects of migrants, underlining their role in the language shift process. The combination of sociohistorical and linguistic evidence gives us a better understanding of language shift in this period, showing the value of an integrated 'from below' approach.

Abstract

Much of human communication and collaboration is predicated on making predictions about others’ actions. Humans frequently use predictions about others’ action mistakes to correct others and spare them mistakes. Such anticipatory correcting reveals a social motivation for unsolicited helping. Cognitively, it requires forward inferences about others’ actions through mental attributions of goal and reality representations. The current study shows that infants spontaneously intervene when an adult is mistaken about the location of an object she is about to retrieve. Infants pointed out a correct location for an adult before she was about to commit a mistake. Infants did not intervene in control conditions when the adult had witnessed the misplacement, or when she did not intend to retrieve the misplaced object. Results suggest that preverbal infants anticipate a person’s mistaken action through mental attributions of both her goal and reality representations, and correct her proactively by spontaneously providing unsolicited information.

Abstract

This study employed a new “anticipatory intervening” paradigm to tease apart false belief and ignorance-based interpretations of 18-month-olds’ helpful informing. We investigated in three experiments whether 18-month-old infants inform an adult selectively about one of the two locations depending on the adult’s belief about which of the two locations held her toy. In experiments 1 and 2, the adult falsely believed that one of the locations held her toy. In experiment 3, the adult was ignorant about which of the two locations held her toy. In all cases, however, the toy had been removed from the locations and the locations contained instead materials which the adult wanted to avoid. In experiments 1 and 2, infants spontaneously and selectively informed the adult about the aversive material in the location the adult falsely believed to hold her toy. In contrast, in experiment 3, infants informed the ignorant adult about both locations equally. Results reveal that infants expected the adult to commit a specific action mistake when she held a false belief, but not when she was ignorant. Further, infants were motivated to intervene proactively. Findings reveal a predictive action-based usage of “theory-of-mind” skills at 18 months of age.

Abstract

The aim of the study was to compare 3- to 8-year-old children’s propensity to antici- pate a comfortable hand posture at the end of a grasping movement ( end-state comfort effect ) between two different object manipulation tasks, the bar-transport task, and the overturned-glass task. In the bar-transport task, participants were asked to insert a verti- cally positioned bar into a small opening of a box. In the overturned-glass task, participants were asked to put an overturned-glass right-side-up on a coaster. Half of the participants experienced action effects (lights) as a consequence of their movements (AE groups), while the other half of the participants did not (No-AE groups). While there was no differ- ence between the AE and No-AE groups, end-state comfort performance differed across age as well as between tasks. Results revealed a significant increase in end-state comfort performance in the bar-transport task from 13% in the 3-year-olds to 94% in the 8-year- olds. Interestingly, the number of children grasping the bar according to end-state comfort doubled from 3 to 4 years and from 4 to 5 years of age. In the overturned-glass task an increase in end-state comfort performance from already 63% in the 3-year-olds to 100% in the 8-year-olds was significant as well. When comparing end-state comfort performance across tasks, results showed that 3- and 4-year-old children were better at manipulating the glass as compared to manipulating the bar, most probably, because children are more familiar with manipulating glasses. Together, these results suggest that preschool years are an important period for the development of motor planning in which the familiarity with the object involved in the task plays a significant role in children’s ability to plan their movements according to end-state comfort.

Abstract

The problem of poor reproducibility of scientific findings has received much attention over recent years, in a variety of fields including psychology and neuroscience. The problem has been partly attributed to publication bias and unwanted practices such as p‐hacking. Low statistical power in individual studies is also understood to be an important factor. In a recent multisite collaborative study, we mapped brain anatomical left–right asymmetries for regional measures of surface area and cortical thickness, in 99 MRI datasets from around the world, for a total of over 17,000 participants. In the present study, we revisited these hemispheric effects from the perspective of reproducibility. Within each dataset, we considered that an effect had been reproduced when it matched the meta‐analytic effect from the 98 other datasets, in terms of effect direction and significance threshold. In this sense, the results within each dataset were viewed as coming from separate studies in an “ideal publishing environment,” that is, free from selective reporting and p hacking. We found an average reproducibility rate of 63.2% (SD = 22.9%, min = 22.2%, max = 97.0%). As expected, reproducibility was higher for larger effects and in larger datasets. Reproducibility was not obviously related to the age of participants, scanner field strength, FreeSurfer software version, cortical regional measurement reliability, or regional size. These findings constitute an empirical illustration of reproducibility in the absence of publication bias or p hacking, when assessing realistic biological effects in heterogeneous neuroscience data, and given typically‐used sample sizes.

Abstract

Left-right asymmetry of the human brain is one of its cardinal features, and also a complex, multivariate trait. Decades of research have suggested that brain asymmetry may be altered in psychiatric disorders. However, findings have been inconsistent and often based on small sample sizes. There are also open questions surrounding which structures are asymmetrical on average in the healthy population, and how variability in brain asymmetry relates to basic biological variables such as age and sex. Over the last four years, the ENIGMA-Laterality Working Group has published six studies of grey matter morphological asymmetry based on total sample sizes from roughly 3,500 to 17,000 individuals, which were between one and two orders of magnitude larger than those published in previous decades. A population-level mapping of average asymmetry was achieved, including an
intriguing fronto-occipital gradient of cortical thickness asymmetry in healthy brains. ENIGMA’s multidataset approach also supported an empirical illustration of reproducibility of hemispheric differences across datasets. Effect sizes were estimated for grey matter asymmetry based on large, international,
samples in relation to age, sex, handedness, and brain volume, as well as for three psychiatric disorders:Autism Spectrum Disorder was associated with subtly reduced asymmetry of cortical thickness at regions spread widely over the cortex; Pediatric Obsessive-Compulsive Disorder was associated with altered subcortical asymmetry; Major Depressive Disorder was not significantly associated with changes
of asymmetry. Ongoing studies are examining brain asymmetry in other disorders. Moreover, a groundwork has been laid for possibly identifying shared genetic contributions to brain asymmetry and disorders.