Publications

Displaying 301 - 400 of 702
  • Klein, W. (1987). Das Geltende, oder: System der Überzeugungen. Zeitschrift für Literaturwissenschaft und Linguistik, (64), 10-31.
  • Klein, W., & Rieck, B.-O. (1982). Der Erwerb der Personalpronomina im ungesteuerten Spracherwerb. Zeitschrift für Literaturwissenschaft und Linguistik, 45, 35-71.
  • Klein, W. (1980). Der stand der Forschung zur deutschen Satzintonation. Linguistische Berichte, 68/80, 3-33.
  • Klein, W. (1987). Eine Verschärfung des Entscheidungsproblems. Rechtshistorisches Journal, 6, 209-210.
  • Klein, W. (1982). Einige Bemerkungen zur Frageintonation. Deutsche Sprache, 4, 289-310.

    Abstract

    In the first, critical part of this study, a small sample of simple German sentences with their empirically determined pitch contours is used to demonstrate the incorrectness of numerous currently hold views of German sentence intonation. In the second, more constructive part, several interrogative sentence types are analysed and an attempt is made to show that intonation, besides other functions, indicates the permantently changing 'thematic score' in on-going discourse as well as certain validity claims.
  • Klein, W. (1982). Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, 12, 7-8.
  • Klein, W., & Winkler, S. (2010). Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik, 158, 5-7.
  • Klein, W., & Winkler, S. (Eds.). (2010). Ambiguität [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, 40(158).
  • Klein, W. (Ed.). (1980). Argumentation [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (38/39).
  • Klein, W. (1980). Argumentation und Argument. Zeitschrift für Literaturwissenschaft und Linguistik, 38/39, 9-57.
  • Klein, W. (1980). Der Stand der Forschung zur deutschen Satzintonation. Linguistische Berichte, (68/80), 3-33.
  • Klein, W. (1971). Eine kommentierte Bibliographie zur Computerlinguistik. Linguistische Berichte, (11), 101-134.
  • Klein, W. (1991). Geile Binsenbüschel, sehr intime Gespielen: Ein paar Anmerkungen über Arno Schmidt als Übersetzer. Zeitschrift für Literaturwissenschaft und Linguistik, 84, 124-129.
  • Klein, W. (1997). Learner varieties are the normal case. The Clarion, 3, 4-6.
  • Klein, W., & Zimmermann, H. (1971). Lemmatisierter Index zu Georg Trakl, Dichtungen. Frankfurt am Main: Athenäum.
  • Klein, W., & Weissenborn, J. (Eds.). (1982). Here and there: Cross-linguistic studies on deixis and demonstration. Amsterdam: Benjamins.
  • Klein, W., & Von Stechow, A. (1982). Intonation und Bedeutung von Fokus. Konstanz: Universität Konstanz.
  • Klein, W. (1997). Nobels Vermächtnis, oder die Wandlungen des Idealischen. Zeitschrift für Literaturwissenschaft und Linguistik, 107, 6-18.

    Abstract

    Nobel's legacy, or the metamorphosis of what is idealistic Ever since the first Nobel prize in literature was awarded to Prudhomme in 1901, the decisions of the Swedish Academy have been subject to criticism. What is surprising in the changing decision policy as well as in its criticism is the fact that Alfred Nobel's original intentions are hardly ever taken into account: the Nobel prize is a philanthropic prize, it is not meant to select and honour the most eminent literary work but the work with maximal benefit to human beings. What is even more surprising is the fact that no one seems to care that the donator's Last Will is regularly broken.
  • Klein, W. (2010). On times and arguments. Linguistics, 48, 1221-1253. doi:10.1515/LING.2010.040.

    Abstract

    Verbs are traditionally assumed to have an “argument structure”, which imposes various constraints on form and meaning of the noun phrases that go with the verb, and an “event structure”, which defines certain temporal characteristics of the “event” to which the verb relates. In this paper, I argue that these two structures should be brought together. The verb assigns descriptive properties to one or more arguments at one or more temporal intervals, hence verbs have an “argument-time structure”. This argument-time structure as well as the descriptive properties connected to it can be modified by various morphological and syntactic operations. This approach allows a relatively simple analysis of familiar but not well-defined temporal notions such as tense, aspect and Aktionsart. This will be illustrated for English. It will be shown that a few simple morphosyntactic operations on the argument-time structure might account for form and meaning of the perfect, the progressive, the passive and related constructions.
  • Klein, W. (1971). Parsing: Studien zur maschinellen Satzanalyse mit Abhängigkeitsgrammatiken und Transformationsgrammatiken. Frankfurt am Main: Athenäum.
  • Klein, W. (1982). Pronoms personnels et formes d'acquisition. Encrages, 8/9, 42-46.
  • Klein, W., & Von Stutterheim, C. (1987). Quaestio und referentielle Bewegung in Erzählungen. Linguistische Berichte, 109, 163-183.
  • Klein, W. (1991). Raumausdrücke. Linguistische Berichte, 132, 77-114.
  • Klein, W. (Ed.). (1997). Technologischer Wandel in den Philologien [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (106).
  • Klein, W., & Von Stutterheim, C. (1991). Text structure and referential movement. Arbeitsberichte des Forschungsprogramms S&P: Sprache und Pragmatik, 22.
  • Klein, W., & Perdue, C. (1997). The basic variety (or: Couldn't natural languages be much simpler?). Second Language Research, 13, 301-347. doi:10.1191/026765897666879396.

    Abstract

    In this article, we discuss the implications of the fact that adult second language learners (outside the classroom) universally develop a well-structured, efficient and simple form of language–the Basic Variety (BV). Three questions are asked as to (1) the structural properties of the BV, (2) the status of these properties and (3) why some structural properties of ‘fully fledged’ languages are more complex. First, we characterize the BV in four respects: its lexical repertoire, the principles according to which utterances are structured, and temporality and spatiality expressed. The organizational principles proposed are small in number, and interact. We analyse this interaction, describing how the BV is put to use in various complex verbal tasks, in order to establish both what its communicative potentialities are, and also those discourse contexts where the constraints come into conflict and where the variety breaks down. This latter phenomenon provides a partial answer to the third question,concerning the relative complexity of ‘fully fledged’ languages–they have devices to deal with such cases. As for the second question, it is argued firstly that the empirically established continuity of the adult acquisition process precludes any assignment of the BV to a mode of linguistic expression (e.g., ‘protolanguage’) distinct from that of ‘fully fledged’ languages and, moreover, that the organizational constraints of the BV belong to the core attributes of the human language capacity, whereas a number of complexifications not attested in the BV are less central properties of this capacity. Finally, it is shown that the notion of feature strength, as used in recent versions of Generative Grammar, allows a straightforward characterization of the BV as a special case of an I-language, in the sense of this theory. Under this perspective, the acquisition of an Ilanguage beyond the BV can essentially be described as a change in feature strength.
  • Klein, W. (1980). Some remarks on Sanders' typology of elliptical coordinations. Linguistics, 18, 871-876.

    Abstract

    Starting with Ross (1970), various proposals have been made to classify elliptical coordinations and to characterize different languages according to the types of ellipses which they admit. Sanders (1977) discusses four of these proposals, shows that they are inadequate on various grounds and proposes a fifth typology whose central claim is 'evidently correct', as he states (p. 258). In the following, I shall briefly outline this typology and then show that it is inadequate, too. Since there is only one language 1 know — German — I will take all my examples from this language. Moreover, all examples will be straightforward and easy to be judged.
  • Klein, W. (Ed.). (1982). Speech, place, and action: Studies of language in context. New York: Wiley.
  • Klein, W. (Ed.). (1987). Sprache und Ritual [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (65).
  • Klein, W. (1980). Vorwort. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, 10, 7-8.
  • Klein, W. (1991). Was kann sich die Übersetzungswissenschaft von der Linguistik erwarten? Zeitschrift für Literaturwissenschaft und Linguistik, 84, 104-123.
  • Klein, W. (Ed.). (1982). Zweitspracherwerb [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (45).
  • Knudsen, B., & Liszkowski, U. (2013). One-year-olds warn others about negative action outcomes. Journal of Cognition and Development, 14, 424-436. doi:10.1080/15248372.2012.689387.

    Abstract

    Warning others about unexpected negative action outcomes is a paradigm case of communicative helping and prospective action understanding. The current study addressed the ontogeny of warning in infants’ gestural communication. We found that 12- and 18-month-olds (n = 84) spontaneously warned an adult by pointing out to her an aversive object hidden in her way (Problem condition). In control conditions the object was either positive (No Problem condition) or the adult had witnessed its’ placing (Problem known condition), which resulted in significantly less pointing. Results show that infants intervene spontaneously and with foresight through communication, in order to help others avoid a problem before it has occurred. These acts of warning entail an understanding of others’ negatively defined goals (to avoid an outcome) and their incorrect representations of reality. Findings support theories of altruism and social-pragmatic competencies in infancy.

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  • Kominsky, J. F., & Casasanto, D. (2013). Specific to whose body? Perspective taking and the spatial mapping of valence. Frontiers in Psychology, 4: 266. doi:10.3389/fpsyg.2013.00266.

    Abstract

    People tend to associate the abstract concepts of “good” and “bad” with their fluent and disfluent sides of space, as determined by their natural handedness or by experimental manipulation (Casasanto, 2011). Here we investigated influences of spatial perspective taking on the spatialization of “good” and “bad.” In the first experiment, participants indicated where a schematically drawn cartoon character would locate “good” and “bad” stimuli. Right-handers tended to assign “good” to the right and “bad” to the left side of egocentric space when the character shared their spatial perspective, but when the character was rotated 180° this spatial mapping was reversed: good was assigned to the character’s right side, not the participant’s. The tendency to spatialize valence from the character’s perspective was stronger in the second experiment, when participants were shown a full-featured photograph of the character. In a third experiment, most participants not only spatialized “good” and “bad” from the character’s perspective, they also based their judgments on a salient attribute of the character’s body (an injured hand) rather than their own body. Taking another’s spatial perspective encourages people to compute space-valence mappings using an allocentric frame of reference, based on the fluency with which the other person could perform motor actions with their right or left hand. When people reason from their own spatial perspective, their judgments depend, in part, on the specifics of their bodies; when people reason from someone else’s perspective, their judgments may depend on the specifics of the other person’s body, instead. - See more at: http://journal.frontiersin.org/Journal/10.3389/fpsyg.2013.00266
  • Kooijman, V., Junge, C., Johnson, E. K., Hagoort, P., & Cutler, A. (2013). Predictive brain signals of linguistic development. Frontiers in Psychology, 4: 25. doi:10.3389/fpsyg.2013.00025.

    Abstract

    The ability to extract word forms from continuous speech is a prerequisite for constructing a vocabulary and emerges in the first year of life. Electrophysiological (ERP) studies of speech segmentation by 9- to 12-month-old listeners in several languages have found a left-localized negativity linked to word onset as a marker of word detection. We report an ERP study showing significant evidence of speech segmentation in Dutch-learning 7-month-olds. In contrast to the left-localized negative effect reported with older infants, the observed overall mean effect had a positive polarity. Inspection of individual results revealed two participant sub-groups: a majority showing a positive-going response, and a minority showing the left negativity observed in older age groups. We retested participants at age three, on vocabulary comprehension and word and sentence production. On every test, children who at 7 months had shown the negativity associated with segmentation of words from speech outperformed those who had produced positive-going brain responses to the same input. The earlier that infants show the left-localized brain responses typically indicating detection of words in speech, the better their early childhood language skills.
  • Kos, M., Vosse, T. G., Van den Brink, D., & Hagoort, P. (2010). About edible restaurants: Conflicts between syntax and semantics as revealed by ERPs. Frontiers in Psychology, 1, E222. doi:10.3389/fpsyg.2010.00222.

    Abstract

    In order to investigate conflicts between semantics and syntax, we recorded ERPs, while participants read Dutch sentences. Sentences containing conflicts between syntax and semantics (Fred eats in a sandwich…/ Fred eats a restaurant…) elicited an N400. These results show that conflicts between syntax and semantics not necessarily lead to P600 effects and are in line with the processing competition account. According to this parallel account the syntactic and semantic processing streams are fully interactive and information from one level can influence the processing at another level. The relative strength of the cues of the processing streams determines which level is affected most strongly by the conflict. The processing competition account maintains the distinction between the N400 as index for semantic processing and the P600 as index for structural processing.
  • Kreuzer, H. (Ed.). (1971). Methodische Perspektiven [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (1/2).
  • Kristensen, L. B., Wang, L., Petersson, K. M., & Hagoort, P. (2013). The interface between language and attention: Prosodic focus marking recruits a general attention network in spoken language comprehension. Cerebral Cortex, 23, 1836-1848. doi:10.1093/cercor/bhs164.

    Abstract

    In spoken language, pitch accent can mark certain information as focus, whereby more attentional resources are allocated to the focused information. Using functional magnetic resonance imaging, this study examined whether pitch accent, used for marking focus, recruited general attention networks during sentence comprehension. In a language task, we independently manipulated the prosody and semantic/pragmatic congruence of sentences. We found that semantic/pragmatic processing affected bilateral inferior and middle frontal gyrus. The prosody manipulation showed bilateral involvement of the superior/inferior parietal cortex, superior and middle temporal cortex, as well as inferior, middle, and posterior parts of the frontal cortex. We compared these regions with attention networks localized in an auditory spatial attention task. Both tasks activated bilateral superior/inferior parietal cortex, superior temporal cortex, and left precentral cortex. Furthermore, an interaction between prosody and congruence was observed in bilateral inferior parietal regions: for incongruent sentences, but not for congruent ones, there was a larger activation if the incongruent word carried a pitch accent, than if it did not. The common activations between the language task and the spatial attention task demonstrate that pitch accent activates a domain general attention network, which is sensitive to semantic/pragmatic aspects of language. Therefore, attention and language comprehension are highly interactive.

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    Kirstensen_Cer_Cor_Suppl_Mat.doc
  • Kupisch, T., Akpinar, D., & Stoehr, A. (2013). Gender assignment and gender agreement in adult bilinguals and second learners of French. Linguistic Approaches to Bilingualism, 3, 150-179. doi:10.1075/lab.3.2.02kup.
  • Ladd, D. R., Turnbull, R., Browne, C., Caldwell-Harris, C., Ganushchak, L. Y., Swoboda, K., Woodfield, V., & Dediu, D. (2013). Patterns of individual differences in the perception of missing-fundamental tones. Journal of Experimental Psychology: Human Perception and Performance, 39(5), 1386-1397. doi:10.1037/a0031261.

    Abstract

    Recent experimental findings suggest stable individual differences in the perception of auditory stimuli lacking energy at the fundamental frequency (F0), here called missing fundamental (MF) tones. Specifically, some individuals readily identify the pitch of such tones with the missing F0 ("F0 listeners"), and some base their judgment on the frequency of the partials that make up the tones ("spectral listeners"). However, the diversity of goals and methods in recent research makes it difficult to draw clear conclusions about individual differences. The first purpose of this article is to discuss the influence of methodological choices on listeners' responses. The second goal is to report findings on individual differences in our own studies of the MF phenomenon. In several experiments, participants judged the direction of pitch change in stimuli composed of two MF tones, constructed so as to reveal whether the pitch percept was based on the MF or the partials. The reported difference between F0 listeners and spectral listeners was replicated, but other stable patterns of responses were also observed. Test-retest reliability is high. We conclude that there are genuine, stable individual differences underlying the diverse findings, but also that there are more than two general types of listeners, and that stimulus variables strongly affect some listeners' responses. This suggests that it is generally misleading to classify individuals as "F0 listeners" or "spectral listeners." It may be more accurate to speak of two modes of perception ("F0 listening" and "spectral listening"), both of which are available to many listeners. The individual differences lie in what conditions the choice between the two modes.
  • Ladd, D. R., & Dediu, D. (2010). Reply to Järvikivi et al. (2010) [Web log message]. Plos One. Retrieved from http://www.plosone.org/article/comments/info%3Adoi%2F10.1371%2Fjournal.pone.0012603.
  • Lai, V. T., & Curran, T. (2013). ERP evidence for conceptual mappings and comparison processes during the comprehension of conventional and novel metaphors. Brain and Language, 127(3), 484-496. doi:10.1016/j.bandl.2013.09.010.

    Abstract

    Cognitive linguists suggest that understanding metaphors requires activation of conceptual mappings between the involved concepts. We tested whether mappings are indeed in use during metaphor comprehension, and what mapping means as a cognitive process with Event-Related Potentials. Participants read literal, conventional metaphorical, novel metaphorical, and anomalous target sentences preceded by primes with related or unrelated mappings. Experiment 1 used sentence-primes to activate related mappings, and Experiment 2 used simile-primes to induce comparison thinking. In the unprimed conditions of both experiments, metaphors elicited N400s more negative than the literals. In Experiment 1, related sentence-primes reduced the metaphor-literal N400 difference in conventional, but not in novel metaphors. In Experiment 2, related simile-primes reduced the metaphor-literal N400 difference in novel, but not clearly in conventional metaphors. We suggest that mapping as a process occurs in metaphors, and the ways in which it can be facilitated by comparison differ between conventional and novel metaphors.

    Additional information

    Lai_2013_supp.docx Erratum figure 1-4
  • Lai, J., & Poletiek, F. H. (2013). How “small” is “starting small” for learning hierarchical centre-embedded structures? Journal of Cognitive Psychology, 25, 423-435. doi:10.1080/20445911.2013.779247.

    Abstract

    Hierarchical centre-embedded structures pose a large difficulty for language learners due to their complexity. A recent artificial grammar learning study (Lai & Poletiek, 2011) demonstrated a starting-small (SS) effect, i.e., staged-input and sufficient exposure to 0-level-of-embedding exemplars were the critical conditions in learning AnBn structures. The current study aims to test: (1) a more sophisticated type of SS (a gradually rather than discretely growing input), and (2) the frequency distribution of the input. The results indicate that SS optimally works under other conditional cues, such as a skewed frequency distribution with simple stimuli being more numerous than complex ones.
  • Lai, V. T., & Boroditsky, L. (2013). The immediate and chronic influence of spatio-temporal metaphors on the mental representations of time in English, Mandarin, and Mandarin-English speakers. Frontiers in Psychology, 4: 142. doi:10.3389/fpsyg.2013.00142.

    Abstract

    In this paper we examine whether experience with spatial metaphors for time has an influence on people’s representation of time. In particular we ask whether spatiotemporal metaphors can have both chronic and immediate effects on temporal thinking. In Study 1, we examine the prevalence of ego-moving representations for time in Mandarin speakers, English speakers, and Mandarin-English (ME) bilinguals. As predicted by observations in linguistic analyses, we find that Mandarin speakers are less likely to take an ego-moving perspective than are English speakers. Further, we find that ME bilinguals tested in English are less likely to take an ego-moving perspective than are English monolinguals (an effect of L1 on meaning-making in L2), and also that ME bilinguals tested in Mandarin are more likely to take an ego-moving perspective than are Mandarin monolinguals (an effect of L2 on meaning-making in L1). These findings demonstrate that habits of metaphor use in one language can influence temporal reasoning in another language, suggesting the metaphors can have a chronic effect on patterns in thought. In Study 2 we test Mandarin speakers using either horizontal or vertical metaphors in the immediate context of the task. We find that Mandarin speakers are more likely to construct front-back representations of time when understanding front-back metaphors, and more likely to construct up-down representations of time when understanding up-down metaphors. These findings demonstrate that spatiotemporal metaphors can also have an immediate influence on temporal reasoning. Taken together, these findings demonstrate that the metaphors we use to talk about time have both immediate and long-term consequences for how we conceptualize and reason about this fundamental domain of experience.
  • Lam, K. J. Y., & Dijkstra, T. (2010). Word repetition, masked orthographic priming, and language switching: Bilingual studies and BIA+ simulations. International Journal of Bilingual Education and Bilingualism, 13, 487-503. doi:10.1080/13670050.2010.488283.

    Abstract

    Daily conversations contain many repetitions of identical and similar word forms. For bilinguals, the words can even come from the same or different languages. How do such repetitions affect the human word recognition system? The Bilingual Interactive Activation Plus (BIA+) model provides a theoretical and computational framework for understanding word recognition and word repetition in bilinguals. The model assumes that both phenomena involve a language non-selective process that is sensitive to the task context. By means of computer simulations, the model can specify both qualitatively and quantitatively how bilingual lexical processing in one language is affected by the other language. Our review discusses how BIA+ handles cross-linguistic repetition and masked orthographic priming data from two key empirical studies. We show that BIA+ can account for repetition priming effects within- and between-languages through the manipulation of resting-level activations of targets and neighbors (words sharing all but one letter with the target). The model also predicts cross-linguistic performance on within- and between-trial orthographic priming without appealing to conscious strategies or task schema competition as an explanation. At the end of the paper, we briefly evaluate the model and indicate future developments.
  • Larson-Prior, L., Oostenveld, R., Della Penna, S., Michalareas, G., Prior, F., Babajani-Feremi, A., Schoffelen, J.-M., Marzetti, L., de Pasquale, F., Pompeo, F. D., Stout, J., Woolrich, M., Luo, Q., Bucholz, R., Fries, P., Pizzella, V., Romani, G., Corbetta, M., & Snyder, A. (2013). Adding dynamics to the Human Connectome Project with MEG. NeuroImage, 80, 190-201. doi:10.1016/j.neuroimage.2013.05.056.

    Abstract

    The Human Connectome Project (HCP) seeks to map the structural and functional connections between network elements in the human brain. Magnetoencephalography (MEG) provides a temporally rich source of information on brain network dynamics and represents one source of functional connectivity data to be provided by the HCP. High quality MEG data will be collected from 50 twin pairs both in the resting state and during performance of motor, working memory and language tasks. These data will be available to the general community. Additionally, using the cortical parcellation scheme common to all imaging modalities, the HCP will provide processing pipelines for calculating connection matrices as a function of time and frequency. Together with structural and functional data generated using magnetic resonance imaging methods, these data represent a unique opportunity to investigate brain network connectivity in a large cohort of normal adult human subjects. The analysis pipeline software and the dynamic connectivity matrices that it generates will all be made freely available to the research community.
  • Lecumberri, M. L. G., Cooke, M., & Cutler, A. (Eds.). (2010). Non-native speech perception in adverse conditions [Special Issue]. Speech Communication, 52(11/12).
  • Lecumberri, M. L. G., Cooke, M., & Cutler, A. (2010). Non-native speech perception in adverse conditions: A review. Speech Communication, 52, 864-886. doi:10.1016/j.specom.2010.08.014.

    Abstract

    If listening in adverse conditions is hard, then listening in a foreign language is doubly so: non-native listeners have to cope with both imperfect signals and imperfect knowledge. Comparison of native and non-native listener performance in speech-in-noise tasks helps to clarify the role of prior linguistic experience in speech perception, and, more directly, contributes to an understanding of the problems faced by language learners in everyday listening situations. This article reviews experimental studies on non-native listening in adverse conditions, organised around three principal contributory factors: the task facing listeners, the effect of adverse conditions on speech, and the differences among listener populations. Based on a comprehensive tabulation of key studies, we identify robust findings, research trends and gaps in current knowledge.
  • Leedham, S. J., Rodenas-Cuadrado, P., Howarth, K., Lewis, A., Mallappa, S., Segditsas, S., Davis, H., Jeffery, R., Rodriguez-Justo, M., Keshav, S., Travis, S. P. L., Graham, T. A., East, J., Clark, S., & Tomlinson, I. P. M. (2013). A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts. Gut, 62(1), 83-93. doi:10.1136/gutjnl-2011-301601.

    Abstract

    Objective Wnt signalling is critical for normal intestinal development and homeostasis. Wnt dysregulation occurs in almost all human and murine intestinal tumours and an optimal but not excessive level of Wnt activation is considered favourable for tumourigenesis. The authors assessed effects of pan-intestinal Wnt activation on tissue homeostasis, taking into account underlying physiological Wnt activity and stem-cell number in each region of the bowel. Design The authors generated mice that expressed temporally controlled, stabilised β-catenin along the crypt–villus axis throughout the intestines. Physiological Wnt target gene activity was assessed in different regions of normal mouse and human tissue. Human intestinal tumour mutation spectra were analysed. Results In the mouse, β-catenin stabilisation resulted in a graduated neoplastic response, ranging from dysplastic transformation of the entire epithelium in the proximal small bowel to slightly enlarged crypts of non-dysplastic morphology in the colorectum. In contrast, stem and proliferating cell numbers were increased in all intestinal regions. In the normal mouse and human intestines, stem-cell and Wnt gradients were non-identical, but higher in the small bowel than large bowel in both species. There was also variation in the expression of some Wnt modulators. Human tumour analysis confirmed that different APC mutation spectra are selected in different regions of the bowel. Conclusions There are variable gradients in stem-cell number, physiological Wnt activity and response to pathologically increased Wnt signalling along the crypt-villus axis and throughout the length of the intestinal tract. The authors propose that this variation influences regional mutation spectra, tumour susceptibility and lesion distribution in mice and humans.
  • Lenkiewicz, P., Pereira, M., Freire, M. M., & Fernandes, J. (2013). The whole mesh deformation model: A fast image segmentation method suitable for effective parallelization. EURASIP Journal on Advances in Signal Processing, 2013: 55. doi:10.1186/1687-6180-2013-55.

    Abstract

    In this article, we propose a novel image segmentation method called the whole mesh deformation (WMD) model, which aims at addressing the problems of modern medical imaging. Such problems have raised from the combination of several factors: (1) significant growth of medical image volumes sizes due to increasing capabilities of medical acquisition devices; (2) the will to increase the complexity of image processing algorithms in order to explore new functionality; (3) change in processor development and turn towards multi processing units instead of growing bus speeds and the number of operations per second of a single processing unit. Our solution is based on the concept of deformable models and is characterized by a very effective and precise segmentation capability. The proposed WMD model uses a volumetric mesh instead of a contour or a surface to represent the segmented shapes of interest, which allows exploiting more information in the image and obtaining results in shorter times, independently of image contents. The model also offers a good ability for topology changes and allows effective parallelization of workflow, which makes it a very good choice for large datasets. We present a precise model description, followed by experiments on artificial images and real medical data.
  • Lev-Ari, S., & Peperkamp, S. (2013). Low inhibitory skill leads to non-native perception and production in bilinguals’ native language. Journal of Phonetics, 41(5), 320-331. doi:10.1016/j.wocn.2013.06.002.

    Abstract

    Learning a second language influences speakers’ first language, but there is great variability in the degree of influence that speakers exhibit. We show that some of this variability is due to individual differences in inhibitory skill. Particularly, we propose that poorer inhibitory skill leads to greater activation of competing items from the language not in use, and that this greater co-activation ultimately leads to greater influence of the co-activated items on one another. Specifically, we show that bilinguals with lower inhibitory skill exhibit greater influence of the second language on the first. Late English–French bilinguals residing in France produced and perceived Voice Onset Time of voiceless stops in English in a more French-like manner, the lower their inhibitory skill was. We discuss the implications of these results for the role of inhibitory skill in shaping representation in bilingual as well as monolingual language processing.
  • Lev-Ari, S., & Keysar, B. (2010). Why don't we believe non-native speakers? The influence of accent on credibility. Journal of Experimental Social Psychology, 46(6), 1093-1096. doi:10.1016/j.jesp.2010.05.025.

    Abstract

    Non-native speech is harder to understand than native speech. We demonstrate that this “processing
    difficulty” causes non-native speakers to sound less credible. People judged trivia statements such as “Ants
    don't sleep” as less true when spoken by a non-native than a native speaker. When people were made aware
    of the source of their difficulty they were able to correct when the accent was mild but not when it was
    heavy. This effect was not due to stereotypes of prejudice against foreigners because it occurred even though
    speakers were merely reciting statements provided by a native speaker. Such reduction of credibility may
    have an insidious impact on millions of people, who routinely communicate in a language which is not their
    native tongue
  • Levelt, W. J. M. (2013). A history of psycholinguistics: The pre-Chomskyan era. Oxford: Oxford University Press.

    Abstract

    Describes the history of the field in terms of its multidisciplinary "roots" so that readers from different disciplines can concentrate on, or selectively read, the corresponding chapters. * Explores the history of research on brain and language, making the book valuable for aphasiologists, communication scientists and neuroscientists of language. * Covers the history of linguistic approaches to psycholinguistics - making the book of interest to both theoretical and applied linguists. * Written by a scientist whose own contribution to the field has been seminal, resulting in a work that will be seen as the definitive of psycholinguistics, for many years to come How do we manage to speak and understand language? How do children acquire these skills and how does the brain support them?These psycholinguistic issues have been studied for more than two centuries. Though many Psycholinguists tend to consider their history as beginning with the Chomskyan "cognitive revolution" of the late 1950s/1960s, the history of empirical psycholinguistics actually goes back to the end of the 18th century. This is the first book to comprehensively treat this "pre-Chomskyan" history. It tells the fascinating history of the doctors, pedagogues, linguists and psychologists who created this discipline, looking at how they made their important discoveries about the language regions in the brain, about the high-speed accessing of words in speaking and listening, on the child's invention of syntax, on the disruption of language in aphasic patients and so much more. The book is both a history of ideas as well of the men and women whose intelligence, brilliant insights, fads, fallacies, cooperations, and rivalries created this discipline. Psycholinguistics has four historical roots, which, by the end of the 19th century, had merged. By then, the discipline, usually called the psychology of language, was established. The first root was comparative linguistics, which raised the issue of the psychological origins of language. The second root was the study of language in the brain, with Franz Gall as the pioneer and the Broca and Wernicke discoveries as major landmarks. The third root was the diary approach to child development, which emerged from Rousseau's Émile. The fourth root was the experimental laboratory approach to speech and language processing, which originated from Franciscus Donders' mental chronometry. Wilhelm Wundt unified these four approaches in his monumental Die Sprache of 1900. These four perspectives of psycholinguistics continued into the 20th century but in quite divergent frameworks. There was German consciousness and thought psychology, Swiss/French and Prague/Viennese structuralism, Russian and American behaviorism, and almost aggressive holism in aphasiology. As well as reviewing all these perspectives, the book looks at the deep disruption of the field during the Third Reich and its optimistic, multidisciplinary re-emergence during the 1950s with the mathematical theory of communication as a major impetus. A tour de force from one of the seminal figures in the field, this book will be essential reading for all linguists, psycholinguists, and psychologists with an interest in language. Readership: Linguists, psychologists, aphasiologists, communication scientists, cognitive (neuro-)scientists, whether professionals or graduate students. Historians of science
  • Levelt, W. J. M. (1991). Die konnektionistische Mode. Sprache und Kognition, 10(2), 61-72.
  • Levelt, W. J. M. (1968). [Review of the book] R.C. Oldfield en J.C. Marshall (eds.), Language. Selected readings. Nederlands tijdschrift voor de psychologie, 23, 474.
  • Levelt, W. J. M. (1997). Kunnen lezen is ongewoon voor horenden en doven. Tijdschrift voor Jeugdgezondheidszorg, 29(2), 22-25.
  • Levelt, W. J. M. (1968). Hans Hörmann, Psychologie der Sprache [Book review]. Lingua, 20, 93-97. doi:10.1016/0024-3841(68)90133-2.
  • Levelt, W. J. M. (1982). Het lineariseringsprobleem van de spreker. Tijdschrift voor Taal- en Tekstwetenschap (TTT), 2(1), 1-15.
  • Levelt, W. J. M., Schriefers, H., Vorberg, D., Meyer, A. S., Pechmann, T., & Havinga, J. (1991). Normal and deviant lexical processing: Reply to Dell and O'Seaghdha. Psychological Review, 98(4), 615-618. doi:10.1037/0033-295X.98.4.615.

    Abstract

    In their comment, Dell and O'Seaghdha (1991) adduced any effect on phonological probes for semantic alternatives to the activation of these probes in the lexical network. We argue that that interpretation is false and, in addition, that the model still cannot account for our data. Furthermore, and different from Dell and O'seaghda, we adduce semantic rebound to the lemma level, where it is so substantial that it should have shown up in our data. Finally, we question the function of feedback in a lexical network (other than eliciting speech errors) and discuss Dell's (1988) notion of a unified production-comprehension system.
  • Levelt, W. J. M. (1968). Om der wille van het taalpsychologisch experiment. Forum der Letteren, 21, 927-928.
  • Levelt, W. J. M. (1968). On binocular rivalry. The Hague: Mouton.
  • Levelt, W. J. M. (1968). R. Quirk en J. Svartvik (eds.), Investigating linguistic acceptability [Book review]. Nederlands tijdschrift voor de psychologie, 32(6), 692.
  • Levelt, W. J. M., & Bonarius, M. (1968). Suffixes as deep structure clues. Heymans Bulletins Psychologische Instituten RU Groningen, HB-68-22EX.
  • Levelt, W. J. M., & Kelter, S. (1982). Surface form and memory in question answering. Cognitive Psychology, 14, 78-106. doi:10.1016/0010-0285(82)90005-6.

    Abstract

    Speakers tend to repeat materials from previous talk. This tendency is experimentally established and manipulated in various question-answering situations. It is shown that a question's surface form can affect the format of the answer given, even if this form has little semantic or conversational consequence, as in the pair Q: (At) what time do you close. A: “(At)five o'clock.” Answerers tend to match the utterance to the prepositional (nonprepositional) form of the question. This “correspondence effect” may diminish or disappear when, following the question, additional verbal material is presented to the answerer. The experiments show that neither the articulatory buffer nor long-term memory is normally involved in this retention of recent speech. Retaining recent speech in working memory may fulfill a variety of functions for speaker and listener, among them the correct production and interpretation of surface anaphora. Reusing recent materials may, moreover, be more economical than regenerating speech anew from a semantic base, and thus contribute to fluency. But the realization of this strategy requires a production system in which linguistic formulation can take place relatively independent of, and parallel to, conceptual planning.
  • Levelt, W. J. M. (1982). Science policy: Three recent idols, and a goddess. IPO Annual Progress Report, 17, 32-35.
  • Levelt, W. J. M., Schriefer, H., Vorberg, D., Meyer, A. S., Pechmann, T., & Havinga, J. (1991). The time course of lexical access in speech production: A study of picture naming. Psychological Review, 98(1), 122-142. doi:10.1037/0033-295X.98.1.122.
  • Levelt, W. J. M. (1982). Zelfcorrecties in het spreekproces. KNAW: Mededelingen van de afdeling letterkunde, nieuwe reeks, 45(8), 215-228.
  • Levinson, S. C. (2010). Advancing our grasp of constrained variation in a crucial cognitive domain [Comment on Doug Jones]. Behavioral and Brain Sciences, 33, 391-392. doi:10.1017/S0140525X1000141X.

    Abstract

    Jones's system of constraints promises interesting insights into the typology of kin term systems. Three problems arise: (1) the conflation of categories with algorithms that assign them threatens to weaken the typological predictions; (2) OT-type constraints have little psychological plausibility; (3) the conflation of kin-term systems and kinship systems may underplay the "utility function" character of real kinship in action.
  • Levinson, S. C., & Senft, G. (1991). Forschungsgruppe für Kognitive Anthropologie - Eine neue Forschungsgruppe in der Max-Planck-Gesellschaft. Linguistische Berichte, 133, 244-246.
  • Levinson, S. C. (1987). Implicature explicated? [Comment on Sperber and Wilson]. Behavioral and Brain Sciences, 10(4), 722-723.

    Abstract

    Comment on Sperber and Wilson
  • Levinson, S. C. (1997). Language and cognition: The cognitive consequences of spatial description in Guugu Yimithirr. Journal of Linguistic Anthropology, 7(1), 98-131. doi:10.1525/jlin.1997.7.1.98.

    Abstract

    This article explores the relation between language and cognition by examining the case of "absolute" (cardinal direction) spatial description in the Australian aboriginal language Guugu Yimithirr. This kind of spatial description is incongruent with the "relative" (e.g., left/right/front/back) spatial description familiar in European languages. Building on Haviland's 1993 analysis of Guugu Yimithirr directionals in speech and gesture, a series of informal experiments were developed. It is shown that Guugu Yimithirr speakers predominantly code for nonverbal memory in "absolute" concepts congruent with their language, while a comparative sample of Dutch speakers do so in "relative" concepts. Much anecdotal evidence also supports this. The conclusion is that Whorfian effects may in fact be demonstrable in the spatial domain.
  • Levinson, S. C. (1997). Language and cognition: The cognitive consequences of spatial description in Guugu Yimithirr. Journal of Linguistic Anthropology, 7(1), 1-35. doi:10.1525/jlin.1997.7.1.98.
  • Levinson, S. C. (2010). Questions and responses in Yélî Dnye, the Papuan language of Rossel Island. Journal of Pragmatics, 42, 2741-2755. doi:10.1016/j.pragma.2010.04.009.

    Abstract

    A corpus of 350 naturally-occurring questions in videotaped interaction shows that questions and their responses in Yélî Dnye (the Papuan language of Rossel Island) both conform to clear universal expectations but also have a number of language-specific peculiarities. They conform in that polar and wh-questions are unrelated in form, wh-questions have the usual sort of special forms, and responses show the same priorities as in other languages (for fast cooperative, adequate answers). But, less expected perhaps, Yélî Dnye polar questions (excepting tags) are unmarked in both morphosyntax and prosody, and the responses include conventional facial expressions, conforming to the propositional response system type (so that assent to ‘He didn’t come?’ means ‘no, he didn’t’). These visual signals are facilitated by high levels of mutual gaze making rapid early responses possible. Tags can occur with non-interrogative illocutionary forces, and could be held to perform speech acts of their own. Wh-questions utilize about a dozen wh-forms, which are only optionally fronted, and there are some interesting specializations of forms (e.g. ‘who’ for any named entities other than places). Most questions of all types are genuinely information seeking, with 27% (mostly tags) seeking confirmation, 19% requesting repair.
  • Levinson, S. C. (2013). Recursion in pragmatics. Language, 89, 149-162. doi:10.1353/lan.2013.0005.

    Abstract

    There has been a recent spate of work on recursion as a central design feature of language. This short report points out that there is little evidence that unlimited recursion, understood as center-embedding, is typical of natural language syntax. Nevertheless, embedded pragmatic construals seem available in every language. Further, much deeper center-embedding can be found in dialogue or conversation structure than can be found in syntax. Existing accounts for the 'performance' limitations on center-embedding are thus thrown into doubt. Dialogue materials suggest that center-embedding is perhaps a core part of the human interaction system, and is for some reason much more highly restricted in syntax than in other aspects of cognition.
  • Levinson, S. C., & Senft, G. (1991). Research group for cognitive anthropology - A new research group of the Max Planck Society. Cognitive Linguistics, 2, 311-312.
  • Levinson, S. C. (1980). Speech act theory: The state of the art. Language teaching and linguistics: Abstracts, 5-24.

    Abstract

    Survey article
  • Levinson, S. C. (1991). Pragmatic reduction of the Binding Conditions revisited. Journal of Linguistics, 27, 107-161. doi:10.1017/S0022226700012433.

    Abstract

    In an earlier article (Levinson, 1987b), I raised the possibility that a Gricean theory of implicature might provide a systematic partial reduction of the Binding Conditions; the briefest of outlines is given in Section 2.1 below but the argumentation will be found in the earlier article. In this article I want, first, to show how that account might be further justified and extended, but then to introduce a radical alternative. This alternative uses the same pragmatic framework, but gives an account better adjusted to some languages. Finally, I shall attempt to show that both accounts can be combined by taking a diachronic perspective. The attraction of the combined account is that, suddenly, many facts about long-range reflexives and their associated logophoricity fall into place.
  • Levinson, S. C. (1987). Pragmatics and the grammar of anaphora: A partial pragmatic reduction of Binding and Control phenomena. Journal of Linguistics, 23, 379-434. doi:10.1017/S0022226700011324.

    Abstract

    This paper is one in a series that develops a pragmatic framework in loose confederation with Jay Atlas and Larry Horn: thus they may or may not be responsible for the ideas contained herein. Jay Atlas provided many comments which I have utilized or perverted as the case may be. The Australian data to which this framework is applied was collected with the financial and personal assistance of many people and agencies acknowledged separately below; but I must single out for special thanks John Haviland, who recommended the study of Guugu Yimidhirr anaphora to me and upon whose grammatical work on Guugu Yimidhirr this paper is but a minor (and perhaps flawed) elaboration. A grant from the British Academy allowed me to visit Haviland in September 1986 to discuss many aspects of Guugu Yimidhirr with him, and I am most grateful to the Academy for funding this trip and to Haviland for generously making available his time, his texts (from which I have drawn many examples, not always with specific acknowledgement) and most especially his expertise. Where I have diverged from his opinion I may well learn to regret it. I must also thank Nigel Vincent for putting me in touch with a number of recent relevant developments in syntax (only some of which I have been able to address) and for suggestions for numerous improvements. In addition, I have benefited immensely for comments on a distinct but related paper (Levinson, 1987) kindly provided by Jay Atlas, John Haviland, John Heritage, Phil Johnson-Laird, John Lyons, Tanya Reinhart, Emanuel Schegloff and an anonymous referee; and from comments on this paper by participants in the Cambridge Linguistics Department seminar where it was first presented (especial thanks to John Lyons and Huang Yan for further comments, and Mary Smith for a counter-example). Despite all this help, there are sure to be errors of data and analysis that I have persisted in. Aid in gathering the Australian data is acknowledged separately below.
  • Levinson, S. C. (2010). Pragmatyka [Polish translation of Pragmatics 1983]. Warsaw: Polish Scientific Publishers PWN.
  • Levinson, S. C., & Majid, A. (2013). The island of time: Yélî Dnye, the language of Rossel Island. Frontiers in Psychology, 4: 61. doi:10.3389/fpsyg.2013.00061.

    Abstract

    This paper describes the linguistic description of time, the accompanying gestural system, and the “mental time lines” found in the speakers of Yélî Dnye, an isolate language spoken offshore from Papua New Guinea. Like many indigenous languages, Yélî Dnye has no fixed anchoring of time and thus no calendrical time. Instead, time in Yélî Dnye linguistic
    description is primarily anchored to the time of speaking, with six diurnal tenses and special nominals for n days from coding time; this is supplemented with special constructions for overlapping events. Consequently there is relatively little cross-over or metaphor from space to time. The gesture system, on the other hand, uses pointing to sun position to indicate time of day and may make use of systematic time lines. Experimental evidence fails to show a single robust axis used for mapping time to space. This suggests that there may not be a strong, universal tendency for systematic space-time mappings.
  • Levinson, S. C., & Evans, N. (2010). Time for a sea-change in linguistics: Response to comments on 'The myth of language universals'. Lingua, 120, 2733-2758. doi:10.1016/j.lingua.2010.08.001.

    Abstract

    This paper argues that the language sciences are on the brink of major changes in primary data, methods and theory. Reactions to ‘The myth of language universals’ ([Evans and Levinson, 2009a] and [Evans and Levinson, 2009b]) divide in response to these new challenges. Chomskyan-inspired ‘C-linguists’ defend a status quo, based on intuitive data and disparate universalizing abstract frameworks, reflecting 30 years of changing models. Linguists driven by interests in richer data and linguistic diversity, ‘D-linguists’, though more responsive to the new developments, have tended to lack an integrating framework. Here we outline such an integrative framework of the kind we were presupposing in ‘Myth’, namely a coevolutionary model of the interaction between mind and cultural linguistic traditions which puts variation central at all levels – a model that offers the right kind of response to the new challenges. In doing so we traverse the fundamental questions raised by the commentary in this special issue: What constitutes the data, what is the place of formal representations, how should linguistic comparison be done, what counts as explanation, what is the source of design in language? Radical changes in data, methods and theory are upon us. The future of the discipline will depend on responses to these changes: either the field turns in on itself and atrophies, or it modernizes, and tries to capitalize on the way language lies at the intersection of all the disciplines interested in human nature.
  • Levshina, N., Geeraerts, D., & Speelman, D. (2013). Mapping constructional spaces: A contrastive analysis of English and Dutch analytic causatives. Linguistics, 51(4), 825-854. doi:10.1515/ling-2013-0028.

    Abstract

    The paper demonstrates how verb and noun classes can be used as a common interface in contrastive Construction Grammar. It presents an innovative approach to the contrastive analysis of constructional spaces (sets of constructions covering a certain semantic domain). We compare English and Dutch analytic causatives by using the statistical technique of multiple correspondence analysis applied to data from large monolingual corpora. The method allows us to explore the common conceptual space of the constructions, in particular the salient semantic dimensions and causation types, which emerge on the basis of co-occurring semantic classes of the nominal and verbal slot fillers in constructional exemplars. The formal patterns of the constructions at different levels of specificity are projected onto this space. Our analyses show that an average Dutch analytic causative refers to more indirect and abstract causation with fewer animate than its English counterpart. We have also found that the languages “cut” the common conceptual space in unique ways, although the semantic areas of many English and Dutch constructions overlap substantially. Nevertheless, the form-meaning mapping in the two languages displays commonalities. Both English and Dutch constructions with prepositionally marked or implicit causees are strongly associated with animate causees. We have also observed a correlation between the directness of causation and the crosslinguistic hierarchy of affectedness marking proposed by Kemmer and Verhagen (1994).
  • Levshina, N., Geeraerts, D., & Speelman, D. (2013). Towards a 3D-grammar: Interaction of linguistic and extralinguistic factors in the use of Dutch causative constructions. Journal of Pragmatics, 52, 34-48. doi:10.1016/j.pragma.2012.12.013.

    Abstract

    The integration of three main dimensions of linguistic usage and variation – formal, social and conceptual – can be seen as a major ambition of the Cognitive Sociolinguistics enterprise. The paper illustrates this theoretical approach with a corpus-based study of near-synonymous causative constructions with doen and laten in the Belgian and Netherlandic varieties of Dutch. A series of quantitative analyses show a complex interplay of the dimensions at different levels of constructional schematicity. At the more schematic level, the results indicate that the effects of transitivity and coreferentiality on the probability of the two constructions are slightly different in the two varieties. However, incorporating the effected predicate slot fillers in a mixed-effect model reveals that these differences can be explained to a large extent by the country-specific lexical patterns. These findings suggest that the interplay of the lectal and conceptual factors in constructional variation should be studied at varying degrees of constructional schematicity.
  • Lieber, R., & Baayen, R. H. (1997). A semantic principle of auxiliary selection in Dutch. Natural Language & Linguistic Theory, 15(4), 789-845.

    Abstract

    We propose that the choice between the auxiliaries hebben 'have' and zijn 'be' in Dutch is determined by a particular semantic feature of verbs. In particular we propose a feature of meaning [IEPS] for 'inferable eventual position or state' that characterizes whether the action denoted by the verb allows us to determine the eventual position or state of the verb's highest argument. It is argued that only verbs which exhibit the feature [+IEPS] or which obtain the feature compositionally in the syntax select zijn as their auxiliary. Our analysis is then compared to a number of other analyses of auxiliary selection in Dutch.

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  • Lindell, A. K., & Kidd, E. (2013). Consumers favor “right brain” training: The dangerous lure of neuromarketing. Mind, Brain and Education, 7(1), 35-39. doi:10.1111/mbe.12005.

    Abstract

    Over the past decade the neuromarketing of educational products has become increasingly common. Researchers have however expressed concern about the misapplication of neuroscience to education marketing, fearing that consumers may be deceived into investing in apparently “brain-based” products under the misapprehension that they will be more effective. This study provides the first demonstration that these fears are justified. We presented 180 participants with one of four advertisements for an identical educational program, named either “Right Brain” or “Right Start” Training; the advertisements either did, or did not, include an MRI brain image in one corner. Results demonstrated that “Right Brain” training was deemed more interesting, educationally valuable, and scientifically strong than an identical product named “Right Start” training. Advertisements including an unrelated brain image enhanced ratings of scientific rationale. These results confirm that by implying a strong scientific basis, “brain-based” product names are remarkably effective in implicitly manipulating consumer opinion.
  • Liszkowski, U. (2010). Deictic and other gestures in infancy. Acción psicológica, 7(2), 21-33. doi:10.5944/ap.7.2.212.
  • Liszkowski, U. (2013). Using theory of mind. Child Development Perspectives, 7, 104-109. doi:10.1111/cdep.12025.

    Abstract

    The ability to flexibly predict others' behaviors has been ascribed to a theory of mind (ToM) system. Most research has focused on formal conceptual definitions of such a system, and the question of whom to credit with a ToM. In this article, I suggest shifting perspective from formal definitions to a usage-based approach. This approach views action within human interaction as central to the emergence and continuous development of the ability to flexibly predict others' behaviors. Addressing the current debate about whether infants have a ToM, I illustrate how infants use flexible action expectations to interact with others appropriately. I also discuss the continuous development of ToM and its natural structure from a usage-based perspective.
  • Liu, J. Z., Tozzi, F., Waterworth, D. M., Pillai, S. G., Muglia, P., Middleton, L., Berrettini, W., Knouff, C. W., Yuan, X., Waeber, G., Vollenweider, P., Preisig, M., Wareham, N. J., Zhao, J. H., Loos, R. J. F., Barroso, I., Khaw, K.-T., Grundy, S., Barter, P., Mahley, R. and 86 moreLiu, J. Z., Tozzi, F., Waterworth, D. M., Pillai, S. G., Muglia, P., Middleton, L., Berrettini, W., Knouff, C. W., Yuan, X., Waeber, G., Vollenweider, P., Preisig, M., Wareham, N. J., Zhao, J. H., Loos, R. J. F., Barroso, I., Khaw, K.-T., Grundy, S., Barter, P., Mahley, R., Kesaniemi, A., McPherson, R., Vincent, J. B., Strauss, J., Kennedy, J. L., Farmer, A., McGuffin, P., Day, R., Matthews, K., Bakke, P., Gulsvik, A., Lucae, S., Ising, M., Brueckl, T., Horstmann, S., Wichmann–, H.-E., Rawal, R., Dahmen, N., Lamina, C., Polasek, O., Zgaga, L., Huffman, J., Campbell, S., Kooner, J., Chambers, J. C., Burnett, M. S., Devaney, J. M., Pichard, A. D., Kent, K. M., Satler, L., Lindsay, J. M., Waksman, R., Epstein, S., Wilson, J. F., Wild, S. H., Campbell, H., Vitart, V., Reilly, M. P., Li, M., Qu, L., Wilensky, R., Matthai, W., Hakonarson, H. H., Rader, D. J., Franke, A., Wittig, M., Schäfer, A., Uda, M., Terracciano, A., Xiao, X., Busonero, F., Scheet, P., Schlessinger, D., St. Clair, D., Rujescu, D., Abecasis, G. R., Grabe, H. J., Teumer, A., Völzke, H., Petersmann, A., John, U., Rudan, I., Hayward, C., Wright, A. F., Kolcic, I., Wright, B. J., Thompson, J. R., Balmforth, A. J., Hall, A. S., Samani, N. J., Anderson, C. A., Ahmad, T., Mathew, C. G., Parkes, M., Satsangi, J., Caulfield, M., Munroe, P. B., Farrall, M., Dominiczak, A., Worthington, J., Thomson, W., Eyre, S., Barton, A., Mooser, V., Francks, C., & Marchini, J. (2010). Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nature Genetics, 42(5), 436-440. doi:10.1038/ng.572.

    Abstract

    Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.
  • Liu, Y.-J., Ehrengruber, M. U., Negwer, M., Shao, H.-J., Cetin, A. H., & Lyon, D. C. (2013). Tracing inputs to inhibitory or excitatory neurons of mouse and cat visual cortex with a targeted rabies virus. Current Biology, 23(18), 1746-1755. doi:10.1016/j.cub.2013.07.033.

    Abstract

    Background Cortical inhibition plays a critical role in controlling and modulating cortical excitation and a more detailed understanding of the neuronal circuits contributing to each will provide more insight into their roles in complex cortical computations. Traditional neuronal tracers lack a means for easily distinguishing between circuits of inhibitory and excitatory neurons. To overcome this limitation, we developed a technique for retrogradely labeling inputs to local clusters of inhibitory or excitatory neurons, but not both, using neurotropic adeno-associated and lentiviral vectors, cell-type specific promoters and a modified rabies virus. Results Applied to primary visual cortex (V1) in mouse, the cell-type specific tracing technique labeled thousands of presynaptically connected neurons, and revealed that the dominant source of input to inhibitory and excitatory neurons is local in origin. Neurons in other visual areas are also labeled; the percentage of these inter-cortical inputs to excitatory neurons is somewhat higher (~20%) than to inhibitory neurons (<10%), suggesting that inter-cortical connections have less direct control over inhibition. The inputs to inhibitory neurons were also traced in cat V1, and when aligned with the orientation preference map, revealed for the first time that long-range inputs to inhibitory neurons are well tuned to orientation. Conclusions These novel findings for inhibitory and excitatory circuits in the visual cortex demonstrate the efficacy of our new technique and its ability to work across species, including larger-brained mammals such as the cat. This paves the way for better understanding the roles of specific cell-types in higher-order perceptual and cognitive processes.

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  • Lloyd, S. E., Günther, W., Pearce, S. H. S., Thomson, A., Bianchi, M. L., Bosio, M., Craig, I. W., Fisher, S. E., Scheinman, S. J., Wrong, O., Jentsch, T. J., & Thakker, R. V. (1997). Characterisation of renal chloride channel, CLCN5, mutations in hypercalciuric nephrolithiasis (kidney stones) disorders. Human Molecular Genetics, 6(8), 1233-1239. doi:10.1093/hmg/6.8.1233.

    Abstract

    Mutations of the renal-specific chloride channel (CLCN5) gene, which is located on chromosome Xp11.22, are associated with hypercalciuric nephrolithiasis (kidney stones) in the Northern European and Japanese populations. CLCN5 encodes a 746 amino acid channel (CLC-5) that has approximately 12 transmembrane domains, and heterologous expression of wild-type CLC-5 in Xenopus oocytes has yielded outwardly rectifying chloride currents that were markedly reduced or abolished by these mutations. In order to assess further the structural and functional relationships of this recently cloned chloride channel, additional CLCN5 mutations have been identified in five unrelated families with this disorder. Three of these mutations were missense (G57V, G512R and E527D), one was a nonsense (R648Stop) and one was an insertion (30:H insertion). In addition, two of the mutations (30:H insertion and E527D) were demonstrated to be de novo, and the G57V and E527D mutations were identified in families of Afro-American and Indian origin, respectively. The G57V and 30:H insertion mutations represent the first CLCN5 mutations to be identified in the N-terminus region, and the R648Stop mutation, which has been observed previously in an unrelated family, suggests that this codon may be particularly prone to mutations. Heterologous expression of the mutations resulted in a marked reduction or abolition of the chloride currents, thereby establishing their functional importance. These results help to elucidate further the structure-function relationships of this renal chloride channel.
  • De Loor, G. P., Jurriens, A. A., Levelt, W. J. M., & Van de Geer, J. P. (1968). Line scan imagery interpretation. Photogrammatic Engineering, 28, 502-510.
  • Lum, J., Kidd, E., Davis, S., & Conti-Ramsden, G. (2010). Longitudinal study of declarative and procedural memory in primary school-aged children. Australian Journal of Psychology, 62(3), 139-148. doi:10.1080/00049530903150547.

    Abstract

    This study examined the development of declarative and procedural memory longitudinally in primary school-aged children. At present, although there is a general consensus that age-related improvements during this period can be found for declarative memory, there are conflicting data on the developmental trajectory of the procedural memory system. At Time 1 children aged around 5½ years were presented with measures of declarative and procedural memory. The tasks were then administered 12 months later. Performance on the declarative memory task was found to improve at a faster rate in comparison to the procedural memory task. The findings of the study support the view that multiple memory systems reach functional maturity at different points in development.
  • Lutte, G., Sarti, S., & Kempen, G. (1971). Le moi idéal de l'adolescent: Recherche génétique, différentielle et culturelle dans sept pays dÉurope. Bruxelles: Dessart.
  • Lüttjohann, A., Schoffelen, J.-M., & Van Luijtelaar, G. (2013). Peri-ictal network dynamics of spike-wave discharges: Phase and spectral characteristics. Experimental Neurology, 239, 235-247. doi:10.1016/j.expneurol.2012.10.021.

    Abstract

    Purpose The brain is a highly interconnected neuronal assembly in which network analyses can greatly enlarge our knowledge on seizure generation. The cortico-thalamo-cortical network is the brain-network of interest in absence epilepsy. Here, network synchronization is assessed in a genetic absence model during 5 second long pre-ictal- > ictal transition periods. Method 16 male WAG/Rij rats were equipped with multiple electrodes targeting layer 4 to 6 of the somatosensory-cortex, rostral and caudal RTN, VPM, anterior-(ATN) and posterior (Po) thalamic nucleus. Local Field Potentials measured during pre-ictal- > ictal transition and during control periods were subjected to time-frequency and pairwise phase consistency analysis. Results Pre-ictally, all channels showed Spike-Wave Discharge (SWD) precursor activity (increases in spectral power), which were earliest and most pronounced in the somatosensory cortex. The caudal RTN decoupled from VPM, Po and cortical layer 4. Strong increases in synchrony were found between cortex and thalamus during SWD. Although increases between cortex and VPM were seen in SWD frequencies and its harmonics, boarder spectral increases (6-48 Hz) were seen between cortex and Po. All thalamic nuclei showed increased phase synchronization with Po but not with VPM. Conclusion Absence seizures are not sudden and unpredictable phenomena: the somatosensory cortex shows highest and earliest precursor activity. The pre-ictal decoupling of the caudal RTN might be a prerequisite of SWD generation. Po nucleus might be the primary thalamic counterpart to the somatosensory-cortex in the generation of the cortico-thalamic-cortical oscillations referred to as SWD.
  • Lynott, D., Connell, L., & Holler, J. (Eds.). (2013). The role of body and environment in cognition. Frontiers in Psychology, 4: 465. doi:10.3389/fpsyg.2013.00465.
  • Maguire, W., McMahon, A., Heggarty, P., & Dediu, D. (2010). The past, present, and future of English dialects: Quantifying convergence, divergence, and dynamic equilibrium. Language Variation and Change, 22, 69-104. doi:10.1017/S0954394510000013.

    Abstract

    This article reports on research which seeks to compare and measure the similarities between phonetic transcriptions in the analysis of relationships between varieties of English. It addresses the question of whether these varieties have been converging, diverging, or maintaining equilibrium as a result of endogenous and exogenous phonetic and phonological changes. We argue that it is only possible to identify such patterns of change by the simultaneous comparison of a wide range of varieties of a language across a data set that has not been specifically selected to highlight those changes that are believed to be important. Our analysis suggests that although there has been an obvious reduction in regional variation with the loss of traditional dialects of English and Scots, there has not been any significant convergence (or divergence) of regional accents of English in recent decades, despite the rapid spread of a number of features such as TH-fronting.
  • Majid, A. (2013). Making semantics and pragmatics “sensory”. Journal of Pragmatics, 58, 48-51. doi:10.1016/j.pragma.2013.09.019.
  • Majid, A., & Levinson, S. C. (2010). WEIRD languages have misled us, too [Comment on Henrich et al.]. Behavioral and Brain Sciences, 33(2-3), 103. doi:10.1017/S0140525X1000018X.

    Abstract

    The linguistic and cognitive sciences have severely underestimated the degree of linguistic diversity in the world. Part of the reason for this is that we have projected assumptions based on English and familiar languages onto the rest. We focus on some distortions this has introduced, especially in the study of semantics.
  • Majid, A., Gaby, A., & Boroditsky, L. (2013). Time in terms of space. Frontiers in Psychology, 4: 554. doi:10.3389/fpsyg.2013.00554.
  • Malpass, D., & Meyer, A. S. (2010). The time course of name retrieval during multiple-object naming: Evidence from extrafoveal-on-foveal effects. Journal of Experimental Psychology: Learning, Memory, and Cognition, 36, 523-537. doi:10.1037/a0018522.

    Abstract

    The goal of the study was to examine whether speakers naming pairs of objects would retrieve the names of the objects in parallel or in equence. To this end, we recorded the speakers’ eye movements and determined whether the difficulty of retrieving the name of the 2nd object affected the duration of the gazes to the 1st object. Two experiments, which differed in the spatial arrangement of the objects, showed that the speakers looked longer at the 1st object when the name of the 2nd object was easy than when it was more difficult to retrieve. Thus, the easy 2nd-object names interfered more with the processing of the 1st object than the more difficult 2nd-object names. In the 3rd experiment, the processing of the 1st object was rendered more difficult by presenting it upside down. No effect of 2nd-object difficulty on the gaze duration for the 1st object was found. These results suggest that speakers can retrieve the names of a foveated and an extrafoveal object in parallel, provided that the processing of the foveated object is not too demanding

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