Publications

Abstract

Human language processing involves combinatorial operations that make human communication stand out in the animal kingdom. These operations rely on a dynamic interplay between the inferior frontal and the posterior temporal cortices. Using source reconstructed magnetoencephalography, we tracked language processing in the brain, in order to investigate how individual words are interpreted when part of sentence context. The large sample size in this study (n = 68) allowed us to assess how event-related activity is associated across distinct cortical areas, by means of inter-areal co-modulation within an individual. We showed that, within 500 ms of seeing a word, the word's lexical information has been retrieved and unified with the sentence context. This does not happen in a strictly feed-forward manner, but by means of co-modulation between the left posterior temporal cortex (LPTC) and left inferior frontal cortex (LIFC), for each individual word. The co-modulation of LIFC and LPTC occurs around 400 ms after the onset of each word, across the progression of a sentence. Moreover, these core language areas are supported early on by the attentional network. The results provide a detailed description of the temporal orchestration related to single word processing in the context of ongoing language.

Abstract

Recent studies have shown that the pupillary light response (PLR) is modulated by higher cognitive functions, presumably through activity in visual sensory brain areas. Here we use the PLR to test the involvement of sensory areas in visual working memory (VWM). In two experiments, participants memorized either bright or dark stimuli. We found that pupils were smaller when a prestimulus cue indicated that a bright stimulus should be memorized; this reflects a covert shift of attention during encoding of items into VWM. Crucially, we obtained the same result with a poststimulus cue, which shows that internal shifts of attention within VWM affect pupil size as well. Strikingly, the effect of VWM content on pupil size was most pronounced immediately after the poststimulus cue, and then dissipated. This suggests that a shift of attention within VWM momentarily activates an "active" memory representation, but that this representation quickly transforms into a "hidden" state that does not rely on sensory areas.

Abstract

n conversations, interlocutors concurrently perform two related processes: speech comprehension and speech planning. We investigated effects of speech planning on comprehension using EEG. Dutch speakers listened to sentences that ended with expected or unexpected target words. In addition, a picture was presented two seconds after target onset (Experiment 1) or 50 ms before target onset (Experiment 2). Participants’ task was to name the picture or to stay quiet depending on the picture category. In Experiment 1, we found a strong N400 effect in response to unexpected compared to expected target words. Importantly, this N400 effect was reduced in Experiment 2 compared to Experiment 1. Unexpectedly, the N400 effect was not smaller in the naming compared to categorization condition. This indicates that conceptual preparation or the decision whether to speak (taking place in both task conditions of Experiment 2) rather than processes specific to word planning interfere with comprehension.

Abstract

Individuals rapidly extract information about others’ social identity, including whether or not they belong to their in-group. Group membership status has been shown to affect how attentively people encode information conveyed by those others. These findings are highly relevant for the field of psycholinguistics where there exists an open debate on how words are represented in the mental lexicon and how abstract or context-specific these representations are. Here, we used a novel word learning paradigm to test our proposal that the group membership status of speakers also affects how speaker-specific representations of novel words are. Participants learned new words from speakers who either attended their own university (in-group speakers) or did not (out-group speakers) and performed a task to measure their individual in-group bias. Then, their source memory of the new words was tested in a recognition test to probe the speaker-specific content of the novel lexical representations and assess how it related to individual in-group biases. We found that speaker group membership and participants’ in-group bias affected participants’ decision biases. The stronger the in-group bias, the more cautious participants were in their decisions. This was particularly applied to in-group related decisions. These findings indicate that social biases can influence recognition threshold. Taking a broader scope, defining how information is represented is a topic of great overlap between the fields of memory and psycholinguistics. Nevertheless, researchers from these fields tend to stay within the theoretical and methodological borders of their own field, missing the chance to deepen their understanding of phenomena that are of common interest. Here we show how methodologies developed in the memory field can be implemented in language research to shed light on an important theoretical issue that relates to the composition of lexical representations.

Abstract

Stimulus-related changes in cerebral blood oxygenation were measured using high-resolution functional magnetic resonance imaging sequentially covering visual occipital areas in contiguous sections. During dynamic imaging, healthy subjects silently viewed pseudowords, single false fonts, or length-matched strings of the same false fonts. The paradigm consisted of a sixfold alternation of an activation and a control task. With pseudowords as activation vs single false fonts as control, responses were seen mainly in medial occipital cortex. These responses disappeared when pseudowords were alternated with false font strings as the control and reappeared when false font strings instead of pseudowords served as activation and were alternated with single false fonts. The string-length contrast alone, therefore, is sufficient to account for the activation pattern observed in medial visual cortex when word-like stimuli are contrasted with single characters.

Abstract

The aim of this paper is to discuss an inherent difficulty of PET (and fMRI) research in language production. On the one hand, language production presupposes some degree of freedom for the subject, on the other hand, interpretability of results presupposes restrictions of this freedom. This difficulty is reflected in the existing PET literature in some neglect of the general principle to design experiments in such a way that the results do not allow for alternative interpretations. It is argued that by narrowing down the scope of experiments a gain in interpretability can be achieved.

Abstract

Mirror-sensory synaesthetes mirror the pain or touch that they observe in other people on their own bodies. This type of synaesthesia has been associated with enhanced empathy. We investigated whether the enhanced empathy of people with mirror-sensory synesthesia influences the experience of situations involving touch or pain and whether it affects their prosocial decision making. Mirror-sensory synaesthetes (N = 18, all female), verified with a touch-interference paradigm, were compared with a similar number of age-matched control individuals (all female). Participants viewed arousing images depicting pain or touch; we recorded subjective valence and arousal ratings, and physiological responses, hypothesizing more extreme reactions in synaesthetes. The subjective impact of positive and negative images was stronger in synaesthetes than in control participants; the stronger the reported synaesthesia, the more extreme the picture ratings. However, there was no evidence for differential physiological or hormonal responses to arousing pictures. Prosocial decision making was assessed with an economic game assessing altruism, in which participants had to divide money between themselves and a second player. Mirror-sensory synaesthetes donated more money than non-synaesthetes, showing enhanced prosocial behaviour, and also scored higher on the Interpersonal Reactivity Index as a measure of empathy. Our study demonstrates the subjective impact of mirror-sensory synaesthesia and its stimulating influence on prosocial behaviour.

Abstract

Phosphomannomutase 2 deficiency, or PMM2-CDG, is the most common congenital disorder of glycosylation and affects over 1000 patients globally. There are no approved drugs that treat the symptoms or root cause of PMM2-CDG. To identify clinically actionable compounds that boost human PMM2 enzyme function, we performed a multispecies drug repurposing screen using a novel worm model of PMM2-CDG, followed by PMM2 enzyme functional studies in PMM2-CDG patient fibroblasts. Drug repurposing candidates from this study, and drug repurposing candidates from a previously published study using yeast models of PMM2-CDG, were tested for their effect on human PMM2 enzyme activity in PMM2-CDG fibroblasts. Of the 20 repurposing candidates discovered in the worm-based phenotypic screen, 12 were plant-based polyphenols. Insights from structure-activity relationships revealed epalrestat, the only antidiabetic aldose reductase inhibitor approved for use in humans, as a first-in-class PMM2 enzyme activator. Epalrestat increased PMM2 enzymatic activity in four PMM2-CDG patient fibroblast lines with genotypes R141H/F119L, R141H/E139K, R141H/N216I and R141H/F183S. PMM2 enzyme activity gains ranged from 30% to 400% over baseline, depending on genotype. Pharmacological inhibition of aldose reductase by epalrestat may shunt glucose from the polyol pathway to glucose-1,6-bisphosphate, which is an endogenous stabilizer and coactivator of PMM2 homodimerization. Epalrestat is a safe, oral and brain penetrant drug that was approved 27 years ago in Japan to treat diabetic neuropathy in geriatric populations. We demonstrate that epalrestat is the first small molecule activator ofPMM2 enzyme activity with the potential to treat peripheral neuropathy and correct the underlying enzyme deficiency in a majority of pediatric and adult PMM2-CDG patients.

Abstract

To communicate, an animal's strategic timing of rhythmic signals is crucial. Evolutionary, game-theoretical, and dynamical systems models can shed light on the interaction between individuals and the associated costs and benefits of signalling at a specific time. Mathematical models that study rhythmic interactions from a strategic or evolutionary perspective are rare in animal communication research. But new inspiration may come from a recent game theory model of how group synchrony emerges from local interactions of oscillatory neurons. In the study, the authors analyse when the benefit of joint synchronization outweighs the cost of individual neurons sending electrical signals to each other. They postulate there is a benefit for pairs of neurons to fire together and a cost for a neuron to communicate. The resulting model delivers a variant of a classical dynamical system, the Kuramoto model. Here, we present an accessible overview of the Kuramoto model and evolutionary game theory, and of the 'oscillatory neurons' model. We interpret the model's results and discuss the advantages and limitations of using this particular model in the context of animal rhythmic communication. Finally, we sketch potential future directions and discuss the need to further combine evolutionary dynamics, game theory and rhythmic processes in animal communication studies.

Abstract

Objective

Researchers in animal cognition, psychophysics, and experimental psychology need to randomise the presentation order of trials in experimental sessions. In many paradigms, for each trial, one of two responses can be correct, and the trials need to be ordered such that the participant’s responses are a fair assessment of their performance. Specifically, in some cases, especially for low numbers of trials, randomised trial orders need to be excluded if they contain simple patterns which a participant could accidentally match and so succeed at the task without learning.
Results

We present and distribute a simple Python software package and tool to produce pseudorandom sequences following the Gellermann series. This series has been proposed to pre-empt simple heuristics and avoid inflated performance rates via false positive responses. Our tool allows users to choose the sequence length and outputs a .csv file with newly and randomly generated sequences. This allows behavioural researchers to produce, in a few seconds, a pseudorandom sequence for their specific experiment. PyGellermann is available at https://github.com/YannickJadoul/PyGellermann.

Abstract

Most bioacoustics software is used to analyse the already collected acoustics data in batch, i.e., after the data-collecting phase of a scientific study. However, experiments based on animal training require immediate and precise reactions from the experimenter, and thus do not easily dovetail with a typical bioacoustics workflow. Bridging this methodological gap, we have developed a custom application to live-monitor the vocal development of harbour seals in a behavioural experiment. In each trial, the application records and automatically detects an animal's call, and immediately measures duration and acoustic measures such as intensity, fundamental frequency, or formant frequencies. It then displays a spectrogram of the recording and the acoustic measurements, allowing the experimenter to instantly evaluate whether or not to reinforce the animal's vocalisation. From a technical perspective, the rapid and easy development of this custom software was made possible by combining multiple open-source software projects. Here, we integrated the acoustic analyses from Parselmouth, a Python library for Praat, together with PyAudio and Matplotlib's recording and plotting functionality, into a custom graphical user interface created with PyQt. This flexible recombination of different open-source Python libraries allows the whole program to be written in a mere couple of hundred lines of code

Abstract

At the group level, children exposed to certain health and demographic risk factors, and who have delayed language in early childhood are, more likely to have language problems later in childhood. However, it is unclear whether we can use these risk factors to predict whether an individual child is likely to develop problems with language (e.g., be diagnosed with a developmental language disorder). We tested this in a sample of 146 children who took part in the UK-CDI norming project. When the children were 15–18 months old, 1,210 British parents completed: (a) the UK-CDI (a detailed assessment of vocabulary and gesture use) and (b) the Family Questionnaire (questions about health and demographic risk factors). When the children were between 4 and 6  years, 146 of the same parents completed a short questionnaire that assessed (a) whether children had been diagnosed with a disability that was likely to affect language proficiency (e.g., developmental disability, language disorder, hearing impairment), but (b) also yielded a broader measure: whether the child’s language had raised any concern, either by a parent or professional. Discriminant function analyses were used to assess whether we could use different combinations of 10 risk factors, together with early vocabulary and gesture scores, to identify children (a) who had developed a language-related disability by the age of 4–6 years (20 children, 13.70% of the sample) or (b) for whom concern about language had been expressed (49 children; 33.56%). The overall accuracy of the models, and the specificity scores were high, indicating that the measures correctly identified those children without a language-related disability and whose language was not of concern. However, sensitivity scores were low, indicating that the models could not identify those children who were diagnosed with a language-related disability or whose language was of concern. Several exploratory analyses were carried out to analyse these results further. Overall, the results suggest that it is difficult to use parent reports of early risk factors and language in the first 2 years of life to predict which children are likely to be diagnosed with a language-related disability. Possible reasons for this are discussed.

Abstract

Research Findings: The present study compared effects of explicit instruction on and practice with the phonological form of words (form-focused instruction) versus explicit instruction on and practice with the meaning of words (meaning-focused instruction). Instruction was given via interactive storybook reading in the kindergarten classroom of children learning Dutch. We asked whether the 2 types of instruction had different effects on vocabulary development and 2 precursors of reading ability—phonological awareness and letter knowledge—and we examined effects on these measures of the ability to learn new words with minimal acoustic-phonetic differences. Learners showed similar receptive target-word vocabulary gain after both types of instruction, but learners who received form-focused vocabulary instruction showed more gain in semantic knowledge of target vocabulary, phonological awareness, and letter knowledge than learners who received meaning-focused vocabulary instruction. Level of ability to learn pairs of words with minimal acoustic-phonetic differences predicted gain in semantic knowledge of target vocabulary and in letter knowledge in the form-focused instruction group only. Practice or Policy: A focus on the form of words during instruction appears to have benefits for young children learning vocabulary.

Abstract

The influence of larynx position on vowel articulation is an important topic in understanding speech production, the present-day distribution of linguistic diversity and the evolution of speech and language in our lineage. We introduce here a realistic computer model of the vocal tract, constructed from actual human MRI data, which can learn, using machine learning techniques, to control the articulators in such a way as to produce speech sounds matching as closely as possible to a given set of target vowels. We systematically control the vertical position of the larynx and we quantify the differences between the target and produced vowels for each such position across multiple replications. We report that, indeed, larynx height does affect the accuracy of reproducing the target vowels and the distinctness of the produced vowel system, that there is a “sweet spot” of larynx positions that are optimal for vowel production, but that nevertheless, even extreme larynx positions do not result in a collapsed or heavily distorted vowel space that would make speech unintelligible. Together with other lines of evidence, our results support the view that the vowel space of human languages is influenced by our larynx position, but that other positions of the larynx may also be fully compatible with speech.

Abstract

Open Science is becoming a mainstream scientific ideology in psychology and related fields. However, researchers, especially early-career researchers (ECRs) in developing countries, are facing significant hurdles in engaging in Open Science and moving it forward. In China, various societal and cultural factors discourage ECRs from participating in Open Science, such as the lack of dedicated communication channels and the norm of modesty. To make the voice of Open Science heard by Chinese-speaking ECRs and scholars at large, the Chinese Open Science Network (COSN) was initiated in 2016. With its core values being grassroots-oriented, diversity, and inclusivity, COSN has grown from a small Open Science interest group to a recognized network both in the Chinese-speaking research community and the international Open Science community. So far, COSN has organized three in-person workshops, 12 tutorials, 48 talks, and 55 journal club sessions and translated 15 Open Science-related articles and blogs from English to Chinese. Currently, the main social media account of COSN (i.e., the WeChat Official Account) has more than 23,000 subscribers, and more than 1,000 researchers/students actively participate in the discussions on Open Science. In this article, we share our experience in building such a network to encourage ECRs in developing countries to start their own Open Science initiatives and engage in the global Open Science movement. We foresee great collaborative efforts of COSN together with all other local and international networks to further accelerate the Open Science movement.

Abstract

In the present study, we used chronometric TMS to probe the time-course of 3 brain regions during a picture naming task. The left inferior frontal gyrus, left posterior middle temporal gyrus, and left posterior superior temporal gyrus were all separately stimulated in 1 of 5 time-windows (225, 300, 375, 450, and 525 ms) from picture onset. We found posterior temporal areas to be causally involved in picture naming in earlier time-windows, whereas all 3 regions appear to be involved in the later time-windows. However, chronometric TMS produces nonspecific effects that may impact behavior, and furthermore, the time-course of any given process is a product of both the involved processing stages along with individual variation in the duration of each stage. We therefore extend previous work in the field by accounting for both individual variations in naming latencies and directly testing for nonspecific effects of TMS. Our findings reveal that both factors influence behavioral outcomes at the group level, underlining the importance of accounting for individual variations in naming latencies, especially for late processing stages closer to articulation, and recognizing the presence of nonspecific effects of TMS. The paper advances key considerations and avenues for future work using chronometric TMS to study overt production.

Abstract

This study investigates effects of prosodic factors (prominence, boundary) on coarticulatory Vnasalization in Australian English (AusE) in CVN and NVC in comparison to those in American English
(AmE). As in AmE, prominence was found to
lengthen N, but to reduce V-nasalization, enhancing N’s nasality and V’s orality, respectively (paradigmatic contrast enhancement). But the prominence effect in CVN was more robust than that in AmE. Again similar to findings in AmE, boundary
induced a reduction of N-duration and V-nasalization phrase-initially (syntagmatic contrast enhancement), and increased the nasality of both C and V phrasefinally.
But AusE showed some differences in terms
of the magnitude of V nasalization and N duration. The results suggest that the linguistic contrast enhancements underlie prosodic-structure modulation of coarticulatory V-nasalization in
comparable ways across dialects, while the fine phonetic detail indicates that the phonetics-prosody interplay is internalized in the individual dialect’s phonetic grammar.

Abstract

This paper compares the focus marking systems and the focus size that can be expressed by the different focus markings in four Mande and three Atlantic languages and varieties, namely: Bambara, Dyula, Kakabe, Soninke (Mande), Wolof, Jóola Foñy and Jóola Karon (Atlantic). All of these languages are known to mark focus morphosyntactically, rather than prosodically, as the more well-studied Germanic languages do. However, the Mande languages under discussion use only morphology, in the form of a particle that follows the focus, while the Atlantic ones use a more complex morphosyntactic system in which focus is marked by morphology in the verbal complex and movement of the focused term. It is shown that while there are some syntactic restrictions to how many different focus sizes can be marked in a distinct way, there is also a certain degree of arbitrariness as to which focus sizes are marked in the same way as each other.

Abstract

This special issue focuses on the theoretical and empirical underpinnings of truth-marking. The names that have been used to refer to this phenomenon include, among others, counter-assertive focus, polar(ity) focus, verum focus, emphatic polarity or simply verum. This terminological variety is suggestive of the wide range of ideas and conceptions that characterizes this research field. This collection aims to get closer to the core of what truly constitutes verum. We want to expand the empirical base and determine the common and diverging properties of truth-marking in the languages of the world. The objective is to set a theoretical and empirical baseline for future research on verum and related phenomena.

Abstract

Objective. The aims of this study were to compare the temporomandibular joint (TMJ) retrodiscal tissue T2 relaxation times between patients with temporomandibular disorders (TMDs) and asymptomatic volunteers and to assess the diagnostic potential of this approach.
Study Design. Patients with TMD (n = 173) and asymptomatic volunteers (n = 17) were examined by using a 1.5-T magnetic resonance scanner. The imaging protocol consisted of oblique sagittal, T2-weighted, 8-echo fast spin echo sequences in the closed mouth position. Retrodiscal tissue T2 relaxation times were obtained. Additionally, disc location and reduction, disc configuration, joint effusion, osteoarthritis, and bone edema or osteonecrosis were classified using MRI scans. The T2 relaxation times of each group were statistically compared.
Results. Retrodiscal tissue T2 relaxation times were significantly longer in patient groups than in asymptomatic volunteers (P < .01). T2 relaxation times were significantly longer in all of the morphologic categories. The most important variables affecting retrodiscal tissue T2 relaxation times were disc configuration, joint effusion, and osteoarthritis.
Conclusion. Retrodiscal tissue T2 relaxation times of patients with TMD were significantly longer than those of healthy volunteers. This finding may lead to the development of a diagnostic marker to aid in the early detection of TMDs.

Abstract

The growing importance of research on bilingualism in psychology and neuroscience motivates the need for a psychometric model that can be used to understand and quantify this phenomenon. This research is the first to meet this need. We reanalyzed two data sets (N = 171 and N = 112) from relatively young adult language-unbalanced bilinguals and asked whether bilingualism is best described by the factor structure or by the network structure. The factor and network models were established on one data set and then validated on the other data set in a fully confirmatory manner. The network model provided the best fit to the data. This implies that bilingualism should be conceptualized as an emergent phenomenon arising from direct and idiosyncratic dependencies among the history of language acquisition, diverse language skills, and language-use practices. These dependencies can be reduced to neither a single universal quotient nor to some more general factors. Additional in-depth network analyses showed that the subjective perception of proficiency along with language entropy and language mixing were the most central indices of bilingualism, thus indicating that these measures can be especially sensitive to variation in the overall bilingual experience. Overall, this work highlights the great potential of psychometric network modeling to gain a more accurate description and understanding of complex (psycho)linguistic and cognitive phenomena.

Abstract

Is visual reinterpretation of bistable figures (e.g., duck/rabbit figure) in visual imagery possible? Current consensus suggests that it is in principle possible because of converging evidence of quasi-pictorial functioning of visual imagery. Yet, studies that have directly tested and found evidence for reinterpretation in visual imagery, allow for the possibility that reinterpretation was already achieved during memorization of the figure(s). One study resolved this issue, providing evidence for reinterpretation in visual imagery (Mast and Kosslyn, Cognition 86:57-70, 2002). However, participants in that study performed reinterpretations with aid of visual cues. Hence, reinterpretation was not performed with mental imagery alone. Therefore, in this study we assessed the possibility of reinterpretation without visual support. We further explored the possible role of haptic cues to assess the multimodal nature of mental imagery. Fifty-three participants were consecutively presented three to be remembered bistable 2-D figures (reinterpretable when rotated 180 degrees), two of which were visually inspected and one was explored hapticly. After memorization of the figures, a visually bistable exemplar figure was presented to ensure understanding of the concept of visual bistability. During recall, 11 participants (out of 36; 30.6%) who did not spot bistability during memorization successfully performed reinterpretations when instructed to mentally rotate their visual image, but additional haptic cues during mental imagery did not inflate reinterpretation ability. This study validates previous findings that reinterpretation in visual imagery is possible.

Abstract

In two experiments, we examined the role of gesture in reinterpreting a mental image. In Experiment 1, we found that participants gestured more about a figure they had learned through manual exploration than about a figure they had learned through vision. This supports claims that gestures emerge from the activation of perception-relevant actions during mental imagery. In Experiment 2, we investigated whether such gestures have a causal role in affecting the quality of mental imagery. Participants were randomly assigned to gesture, not gesture, or engage in a manual interference task as they attempted to reinterpret a figure they had learned through manual exploration. We found that manual interference significantly impaired participants' success on the task. Taken together, these results suggest that gestures reflect mental imaginings of interactions with a mental image and that these imaginings are critically important for mental manipulation and reinterpretation of that image. However, our results suggest that enacting the imagined movements in gesture is not critically important on this particular task.

Abstract

Sign language is a rich form of communication, uniquely conveying meaning through a combination of gestures, facial expressions, and body movements. Existing research in sign language generation has predominantly focused on text-to-sign pose generation, while speech-to-sign pose generation remains relatively underexplored. Speech-to-sign language generation models can facilitate effective communication between the deaf and hearing communities. In this paper, we propose an architecture that utilises prosodic information from speech audio and semantic context from text to generate sign pose sequences. In our approach, we adopt a multi-tasking strategy that involves an additional task of predicting Facial Action Units (FAUs). FAUs capture the intricate facial muscle movements that play a crucial role in conveying specific facial expressions during sign language generation. We train our models on an existing Indian Sign language dataset that contains sign language videos with audio and text translations. To evaluate our models, we report Dynamic Time Warping (DTW) and Probability of Correct Keypoints (PCK) scores. We find that combining prosody and text as input, along with incorporating facial action unit prediction as an additional task, outperforms previous models in both DTW and PCK scores. We also discuss the challenges and limitations of speech-to-sign pose generation models to encourage future research in this domain. We release our models, results and code to foster reproducibility and encourage future research1.

Abstract

Prior work with hearing children acquiring a spoken language as their first language shows that spatial language and cognition are related systems and spatial language use predicts spatial memory. Here, we further investigate the extent of this relationship in signing deaf children and adults and ask if late sign language exposure, as well as the frequency and the type of spatial language use that might be affected by late exposure, modulate subsequent memory for spatial relations. To do so, we compared spatial language and memory of 8-year-old late-signing children (after 2 years of exposure to a sign language at the school for the deaf) and late-signing adults to their native-signing counterparts. We elicited picture descriptions of Left-Right relations in Turkish Sign Language (Türk İşaret Dili) and measured the subsequent recognition memory accuracy of the described pictures. Results showed that late-signing adults and children were similar to their native-signing counterparts in how often they encoded the spatial relation. However, late-signing adults but not children differed from their native-signing counterparts in the type of spatial language they used. However, neither late sign language exposure nor the frequency and type of spatial language use modulated spatial memory accuracy. Therefore, even though late language exposure seems to influence the type of spatial language use, this does not predict subsequent memory for spatial relations. We discuss the implications of these findings based on the theories concerning the correspondence between spatial language and cognition as related or rather independent systems.

Abstract

Childhood apraxia of speech (CAS), the prototypic severe childhood speech disorder, is characterized by motor programming and planning deficits. Genetic factors make substantive contributions to CAS aetiology, with a monogenic pathogenic variant identified in a third of cases, implicating around 20 single genes to date. Here we aimed to identify molecular causation in 70 unrelated probands ascertained with CAS. We performed trio genome sequencing. Our bioinformatic analysis examined single nucleotide, indel, copy number, structural and short tandem repeat variants. We prioritised appropriate variants arising de novo or inherited that were expected to be damaging based on in silico predictions. We identified high confidence variants in 18/70 (26%) probands, almost doubling the current number of candidate genes for CAS. Three of the 18 variants affected SETBP1, SETD1A and DDX3X, thus confirming their roles in CAS, while the remaining 15 occurred in genes not previously associated with this disorder. Fifteen variants arose de novo and three were inherited. We provide further novel insights into the biology of child speech disorder, highlighting the roles of chromatin organization and gene regulation in CAS, and confirm that genes involved in CAS are co-expressed during brain development. Our findings confirm a diagnostic yield comparable to, or even higher, than other neurodevelopmental disorders with substantial de novo variant burden. Data also support the increasingly recognised overlaps between genes conferring risk for a range of neurodevelopmental disorders. Understanding the aetiological basis of CAS is critical to end the diagnostic odyssey and ensure affected individuals are poised for precision medicine trials.

Abstract

Intergroup variation (IGV) refers to variation between different groups of the same species. While its existence in the behavioural realm has been expected and evidenced, the potential effects of IGV are rarely considered in studies that aim to shed light on the evolutionary origins of human socio-cognition, especially in our closest living relatives—the great apes. Here, by taking chimpanzees as a point of reference, we argue that (i) IGV could plausibly explain inconsistent research findings across numerous topics of inquiry (experimental/behavioural studies on chimpanzees), (ii) understanding the evolutionary origins of behaviour requires an accurate assessment of species' modes of behaving across different socio-ecological contexts, which necessitates a reliable estimation of variation across intraspecific groups, and (iii) IGV in the behavioural realm is increasingly likely to be expected owing to the progressive identification of non-human animal cultures. With these points, and by extrapolating from chimpanzees to generic guidelines, we aim to encourage researchers to explicitly consider IGV as an explanatory variable in future studies attempting to understand the socio-cognitive and evolutionary determinants of behaviour in group-living animals.

Abstract

It is an important feature of the human sentence production system that semantic and syntactic processes may overlap in time and do not proceed strictly serially. That is, the process of building the syntactic form of an utterance does not always wait until the complete semantic content for that utterance has been decided upon. On the contrary, speakers will often start pronouncing the first words of a sentence while still working on further details of its semantic content. An important advantage is memory economy. Semantic and syntactic fragments do not have to occupy working memory until complete semantic and syntactic structures for an utterance have been computed. Instead, each semantic and syntactic fragment is processed as soon as possible and is kept in working memory for a minimum period of time. This raises the question of how the sentence production system can maintain syntactic coherence across syntactic fragments. Presumably there are processes of "syntactic bookkeeping" which (1) store in working memory those syntactic properties of a fragmentary sentence which are needed to eliminate ungrammatical continuations, and (2) check whether a prospective continuation is indeed compatible with the sentence constructed so far. In reaction time experiments where subjects described, under time pressure, simple static pictures of an action performed by an actor, the second aspect of syntactic bookkeeping could be demonstrated. This evidence is used for modelling bookkeeping processes as part of a computational sentence generator which aims at simulating the syntactic operations people carry out during spontaneous speech.

Abstract

This paper presents a theory of the syntactic aspects of human sentence production. An important characteristic of unprepared speech is that overt pronunciation of a sentence can be initiated before the speaker has completely worked out the meaning content he or she is going to express in that sentence. Apparently, the speaker is able to build up a syntactically coherent utterance out of a series of syntactic fragments each rendering a new part of the meaning content. This incremental, left-to-right mode of sentence production is the central capability of the proposed Incremental Procedural Grammar (IPG). Certain other properties of spontaneous speech, as derivable from speech errors, hesitations, self-repairs, and language pathology, are accounted for as well. The psychological plausibility thus gained by the grammar appears compatible with a satisfactory level of linguistic plausibility in that sentences receive structural descriptions which are in line with current theories of grammar. More importantly, an explanation for the existence of configurational conditions on transformations and other linguistics rules is proposed. The basic design feature of IPG which gives rise to these psychologically and linguistically desirable properties, is the “Procedures + Stack” concept. Sentences are built not by a central constructing agency which overlooks the whole process but by a team of syntactic procedures (modules) which work-in parallel-on small parts of the sentence, have only a limited overview, and whose sole communication channel is a stock. IPG covers object complement constructions, interrogatives, and word order in main and subordinate clauses. It handles unbounded dependencies, cross-serial dependencies and coordination phenomena such as gapping and conjunction reduction. It is also capable of generating self-repairs and elliptical answers to questions. IPG has been implemented as an incremental Dutch sentence generator written in LISP.

Abstract

Human speakers often produce sentences incrementally. They can start speaking having in mind only a fragmentary idea of what they want to say, and while saying this they refine the contents underlying subsequent parts of the utterance. This capability imposes a number of constraints on the design of a syntactic processor. This paper explores these constraints and evaluates some recent computational sentence generators from the perspective of incremental production.

Abstract

We report a hitherto unknown statistical relationship between the corpus frequency of finite verbs and their fixed linear positions (early vs. late) in finite clauses of English, Dutch, and German. Compared to the overall frequency distribution of verb lemmas in the corpora, high-frequency finite verbs are overused in main clauses, at the expense of nonfinite verbs. This finite versus nonfinite split of high-frequency verbs is basically absent from subordinate clauses. Furthermore, this “main-clause bias” (MCB) of high-frequency verbs is more prominent in German and Dutch (SOV languages) than in English (an SVO language). We attribute the MCB and its varying effect sizes to faster accessibility of high-frequency finite verbs, which (1) increases the probability for these verbs to land in clauses mandating early verb placement, and (2) boosts the activation of clause plans that assign verbs to early linear positions (in casu: clauses with SVO as opposed to SOV order).

Abstract

Essays van psychologen en linguı̈sten over de relatie hersens-computers.

Abstract

Remarques sur les facteurs intervenant dans le processus de formulation des énoncés.

Abstract

The psychology of language as developed by Wilhelm Wundt in his fundamental work Die Sprache (1900) has a strongly mentalistic character. The dominating positions held by behaviorism in psychology and structuralism in linguistics have overruled Wundt’s language theory to the effect that it has remained relatively unknown. This situation has changed recently under the influence of transformational linguistics and cognitive psychology. The paper discusses how Wundt applied the basic psychological concepts of apperception and association to language behavior, in particular to the construction and production of sentences during unprepared speech. The final part of the paper is devoted to the work, published in 1917, of the Dutch linguistic scholar Jacques van Ginneken, who elaborated Wundt’s ideas towards an explanation of some syntactic phenomena during the language acquisition of children.

Abstract

[Seven one-page psycholinguistic sketches]

Abstract

Human communicative interaction is characterized by rapid and precise turn-taking. This is achieved by an intricate system that has been elucidated in the field of conversation analysis, based largely on the study of the auditory signal. This model suggests that transitions occur at points of possible completion identified in terms of linguistic units. Despite this, considerable evidence exists that visible bodily actions including gaze and gestures also play a role. To reconcile disparate models and observations in the literature, we combine qualitative and quantitative methods to analyse turn-taking in a corpus of multimodal interaction using eye-trackers and multiple cameras. We show that transitions seem to be inhibited when a speaker averts their gaze at a point of possible turn completion, or when a speaker produces gestures which are beginning or unfinished at such points. We further show that while the direction of a speaker's gaze does not affect the speed of transitions, the production of manual gestures does: turns with gestures have faster transitions. Our findings suggest that the coordination of transitions involves not only linguistic resources but also visual gestural ones and that the transition-relevance places in turns are multimodal in nature.

Abstract

The present study investigates the developmental trajectory of abstract representations for syntactic structures in children. In a structural priming experiment on the dative alternation in German, we primed children from three different age groups (3–4 years, 5–6 years, 7–8 years) and adults with double object datives (Dora sent Boots the rabbit) or prepositional object datives (Dora sent the rabbit to Boots). Importantly, the prepositional object structure in German is dispreferred and only rarely encountered by young children. While immediate as well as cumulative structural priming effects occurred across all age groups, these effects were strongest in the 3- to 4-year-old group and gradually decreased with increasing age. These results suggest that representations in young children are less stable than in adults and, therefore, more susceptible to adaptation both immediately and across time, presumably due to stronger surprisal. Lexical boost effects, in contrast, were not present in 3- to 4-year-olds but gradually emerged with increasing age, possibly due to limited working-memory capacity in the younger child groups.

Abstract

English speakers have been shown to map abstract concepts in space, which occurs on both the vertical and horizontal dimensions. For example, words such as God are associated with up and right spatial locations, and words such as Satan with down and left. If the tendency to map concepts in space is a universal property of human cognition, then it is likely that such mappings may be at least partly culturally-specific, since many concepts are themselves language-specific and therefore cultural conventions. Here we investigated whether Mandarin speakers report spatial mapping of concepts, and how these mappings compare with English speakers (i.e. are words with the same meaning associated with the same spatial locations). Across two studies, results showed that both native English and Mandarin speakers reported spatial mapping of concepts, and that the distribution of mappings was highly similar for the two groups. Theoretical implications are discussed.

Abstract

Statistical learning (SL)—sensitivity to statistical regularities in the environment—has been postulated to support language development. While even young infants are capable of using distributional statistics to learn in linguistic and non-linguistic domains, efforts to measure SL at the level of the individual and link it to language proficiency in individual differences designs have been mixed, which has at least in part been attributed to problems with task reliability. In the current study we present the first prospective longitudinal study of the relationship between both non-linguistic SL (measured with visual stimuli) and linguistic SL (measured with auditory stimuli) and language in a group of English-speaking children. One-hundred and twenty-one (N = 121) children in their first two years of formal schooling (Mage = 6;1 years, Range: 5;2 – 7;2) completed tests of visual SL (VSL) and auditory SL (ASL) and several control variables at time 1. Both forms of SL were then measured every 6 months for the next 18 months, and at the final testing session (time 4) their language proficiency was measured using a standardised test. The results showed that the reliability of the SL tasks increased across the course of the study. A series of path analyses showed that both VSL and ASL independently predicted individual differences in language proficiency at time 4. The evidence is consistent with the suggestion that, when measured reliably, an observable relationship between SL and language proficiency exists. Theoretical and methodological issues are discussed.

Abstract

We investigate whether grammatical information is accessed in processing noun phrase ellipsis (NPE) and other anaphoric constructions. The first experiment used an agreement attraction paradigm to reveal that ungrammatical plural verbs following NPE with an antecedent containing a plural modifier (e.g. Derek’s key to the boxes … and Mary’s_ probably *are safe in the drawer) show similar facilitation to non-elided NPs. The second experiment used the same paradigm to examine a coordination construction without anaphoric elements, and the third examined anaphoric one. Agreement attraction was not observed in either experiment, suggesting that processing NPE is different from processing non-anaphoric coordination constructions or anaphoric one. Taken together, the results indicate that the parser is sensitive to grammatical distinctions at the ellipsis site where it prioritises and retrieves the head at the initial stage of processing and retrieves the local noun within the modifier phrase only when it is necessary in parsing NPE.

Abstract

It is well-established that allographs like the uppercase and lowercase forms of the Roman alphabet (e.g., a and A) map onto the same "abstract letter identity," orthographic representations that are independent of the visual form. Consistent with this, in the allograph match task ("Are 'a' and 'A' the same letter?"), priming by a masked letter prime is equally robust for visually dissimilar prime-target pairs (e.g., d and D) and similar pairs (e.g., c and C). However, in principle this pattern of priming is also consistent with the possibility that allograph priming is purely phonological, based on the letter name. Because different allographic forms of the same letter, by definition, share a letter name, it is impossible to rule out this possibility a priori. In the present study, we investigated the influence of shared letter names by taking advantage of the fact that Japanese is written in two distinct writing systems, syllabic kana-that has two parallel forms, hiragana and katakana-and logographic kanji. Using the allograph match task, we tested whether a kanji prime with the same pronunciation as the target kana (e.g., both pronounced /i/) produces the same amount of priming as a kana prime in the opposite kana form (e.g.,). We found that the kana primes produced substantially greater priming than the phonologically identical kanji prime. which we take as evidence that allograph priming is based on abstract kana identity, not purely phonology.

Abstract

The Japanese kana syllabary has 2 allographic forms, hiragana and katakana. As with other allographic variants like the uppercase and lowercase letters of the Roman alphabet, they show robust formindependent priming effects in the allograph match task (e.g., Kinoshita. Schubert. & Verdonschot, 2019). suggesting that they share abstract character-level representations. In direct contradiction, Perea. Nakayama, and Lupker (2017) argued that hiragana and katakana do not share character-level representations. based on their finding of reduced priming with identity prime containing a mix of hiragana and katakana (the mixed-kana prime) relative to the all-katakana identity prime in a lexical-decision task with loanword targets written in katakana. Here we sought to reconcile these seemingly contradictory claims, using mixed-kana. hiragana, and katakana primes in lexical decision. The mixed-kana prime and hiragana prime produced priming effects that are indistinguishable, and both were reduced in size relative to the priming effect produced by the katakana identity prime. Furthermore, this pattern was unchanged when the target was presented in hiragana. The findings are interpreted in terms of the assumption that the katakana format is specified in the orthographic representation of loanwords in Japanese readers. Implications of the account for the universality across writing systems is discussed.

Abstract

In a Turing test, a judge decides whether their conversation partner is either a machine or human. What cues does the judge use to determine this? In particular, are presumably unique features of human language actually perceived as humanlike? Participants rated the humanness of a set of sentences that were manipulated for grammatical construction: linear right-branching or hierarchical center-embedded and their plausibility with regard to world knowledge.

We found that center-embedded sentences are perceived as less humanlike than right-branching sentences and more plausible sentences are regarded as more humanlike. However, the effect of plausibility of the sentence on perceived humanness is smaller for center-embedded sentences than for right-branching sentences.

Participants also rated a conversation with either correct or incorrect use of the context by the agent. No effect of context use was found. Also, participants rated a full transcript of either a real human or a real chatbot, and we found that chatbots were reliably perceived as less humanlike than real humans, in line with our expectation. We did, however, find individual differences between chatbots and humans.

Abstract

In the first, critical part of this study, a small sample of simple German sentences with their empirically determined pitch contours is used to demonstrate the incorrectness of numerous currently hold views of German sentence intonation. In the second, more constructive part, several interrogative sentence types are analysed and an attempt is made to show that intonation, besides other functions, indicates the permantently changing 'thematic score' in on-going discourse as well as certain validity claims.

Abstract

Nobel's legacy, or the metamorphosis of what is idealistic Ever since the first Nobel prize in literature was awarded to Prudhomme in 1901, the decisions of the Swedish Academy have been subject to criticism. What is surprising in the changing decision policy as well as in its criticism is the fact that Alfred Nobel's original intentions are hardly ever taken into account: the Nobel prize is a philanthropic prize, it is not meant to select and honour the most eminent literary work but the work with maximal benefit to human beings. What is even more surprising is the fact that no one seems to care that the donator's Last Will is regularly broken.

Abstract

In this article, we discuss the implications of the fact that adult second language learners (outside the classroom) universally develop a well-structured, efficient and simple form of language–the Basic Variety (BV). Three questions are asked as to (1) the structural properties of the BV, (2) the status of these properties and (3) why some structural properties of ‘fully fledged’ languages are more complex. First, we characterize the BV in four respects: its lexical repertoire, the principles according to which utterances are structured, and temporality and spatiality expressed. The organizational principles proposed are small in number, and interact. We analyse this interaction, describing how the BV is put to use in various complex verbal tasks, in order to establish both what its communicative potentialities are, and also those discourse contexts where the constraints come into conflict and where the variety breaks down. This latter phenomenon provides a partial answer to the third question,concerning the relative complexity of ‘fully fledged’ languages–they have devices to deal with such cases. As for the second question, it is argued firstly that the empirically established continuity of the adult acquisition process precludes any assignment of the BV to a mode of linguistic expression (e.g., ‘protolanguage’) distinct from that of ‘fully fledged’ languages and, moreover, that the organizational constraints of the BV belong to the core attributes of the human language capacity, whereas a number of complexifications not attested in the BV are less central properties of this capacity. Finally, it is shown that the notion of feature strength, as used in recent versions of Generative Grammar, allows a straightforward characterization of the BV as a special case of an I-language, in the sense of this theory. Under this perspective, the acquisition of an Ilanguage beyond the BV can essentially be described as a change in feature strength.

Abstract

Neurons of the neocortex are organized into six radial layers, which have appeared at different times during evolution, with the superficial layers representing a more recent acquisition. Input to the neocortex predominantly reaches superficial layers (SL, i.e., layers (L) 2-4), while output is generated in deep layers (DL, i.e., L5-6) [1]. Intracortical connections, which bridge input and output pathways, are key components of cortical circuits because they allow the propagation and processing of information within the neocortex. Two main types of intracortically projecting neurons (ICPN) can be distinguished by their axonal features: L4 spiny stellate neurons (SSN) with short axons projecting locally within cortical columns [2, 3, 4, 5], and SL and DL long-range projection neurons, including callosally projecting neurons (CPNSL and CPNDL) [5, 6]. Here, we investigate the molecular hallmarks that distinguish SSN, CPNSL, and CPNDL and relate their transcriptional signatures with their output connectivity. Specifically, taking advantage of the presence of CPN in both SL and DL, we identify lamina-independent genetic hallmarks of a constant projection motif (i.e., interhemispheric projection). By performing unbiased transcriptomic comparisons between CPNSL, CPNDL and SSN, we provide specific molecular profiles for each of these populations and show that target identity supersedes laminar position in defining ICPN transcriptional diversity. Together, these findings reveal a projection-based organization of transcriptional programs across cortical layers, which we propose reflects conserved strategy to protect canonical circuit structure (and hence function) across a diverse range of neuroanatomies.

Abstract

An important question in predictive language processing is the extent to which prediction effects can reliably be measured on pre-nominal material (e.g. articles before nouns). Here, we present a large sample (N = 58) close replication of a study by Otten and van Berkum (2009). They report ERP modulations in relation to the predictability of nouns in sentences, measured on gender-marked Dutch articles. We used nearly identical materials, procedures, and data analysis steps. We fail to replicate the original effect, but do observe a pattern consistent with the original data. Methodological differences between our replication and the original study that could potentially have contributed to the diverging results are discussed. In addition, we discuss the suitability of Dutch gender-marked determiners as a test-case for future studies of pre-activation of lexical items.

Abstract

Objective The aim of the study was to perform a systematic literature search and meta-analysis to reveal the most effective mouthwash for head and neck cancer patients who are experiencing radiation therapy-induced mucositis. Methods Using two electronic databases, a literature search and data interpretation were systematically performed as follows: (i) problem specification, (ii) devising of a literature search plan, (iii) literature search and retrieval of publications, and (iv) meta-analysis and data interpretation. The main problem was specified as follows: what mouthwash is effective in alleviating oral mucositis for head and neck cancer patients who are undergoing radiotherapy? Results The literature search yielded 354 titles and abstracts. After reviewing the extracted literature, 25 publications met the inclusion criteria for this study and 17 of 25 were eventually evaluated in the meta-analysis. Conclusion The results of the meta-analysis indicated that the use of a mouthwash that includes anti-inflammatory properties contributes the most to alleviating oral mucositis in patients who are undergoing radiotherapy to treat head and neck cancer.

Abstract

An important dimension of linguistic variation is formality. This study investigates the role of social distance between interlocutors. Twenty-five native Dutch speakers retold eight short films to confederates, who acted either formally or informally. Speakers were familiarized with the informal confederates, whereas the formal confederates remained strangers. Results show that the two types of interlocutors elicited different versions of the same stories. Formal interlocutors (large social distance) elicited lower articulation rates, and more nouns and prepositions, both indicators of explicit information. Speakers addressing interlocutors to whom social distance was small, however, provided more explicit information with an involved character (i.e. adjectives with subjective meanings). They also used the word and more often as a gap filler or as a way to keep the floor. Furthermore, they were more likely to laugh and to use more interjections, first-person pronouns and direct speech, which are all indicators of involvement, empathy and subjectivity.

Abstract

Rules of behavior are fundamental to human sociality. Whether on the road, at the dinner table, or during a game, people monitor one another’s behavior for conformity to rules and may take action to rectify violations. In this study, we examine two ways in which rules are enforced during games: instructions and reminders. Building on prior research, we identify instructions as actions produced to rectify violations based on another’s lack of knowledge of the relevant rule; knowledge that the instruction is designed to impart. In contrast to this, the actions we refer to as reminders are designed to enforce rules presupposing the transgressor’s competence and treating the violation as the result of forgetfulness or oversight. We show that instructing and reminding actions differ in turn design, sequential development, the epistemic stances taken by transgressors and enforcers, and in how the action affects the progressivity of the interaction. Data are in German and Italian from the Parallel European Corpus of Informal Interaction (PECII).

Abstract

During listening, brain activity tracks the rhythmic structures of speech signals. Here, we directly dissociated the contribution of neural envelope tracking in the processing of speech acoustic cues from that related to linguistic processing. We examined the neural changes associated with the comprehension of Noise-Vocoded (NV) speech using magnetoencephalography (MEG). Participants listened to NV sentences in a 3-phase training paradigm: (1) pre-training, where NV stimuli were barely comprehended, (2) training with exposure of the original clear version of speech stimulus, and (3) post-training, where the same stimuli gained intelligibility from the training phase. Using this paradigm, we tested if the neural responses of a speech signal was modulated by its intelligibility without any change in its acoustic structure. To test the influence of spectral degradation on neural envelope tracking independently of training, participants listened to two types of NV sentences (4-band and 2-band NV speech), but were only trained to understand 4-band NV speech. Significant changes in neural tracking were observed in the delta range in relation to the acoustic degradation of speech. However, we failed to find a direct effect of intelligibility on the neural tracking of speech envelope in both theta and delta ranges, in both auditory regions-of-interest and whole-brain sensor-space analyses. This suggests that acoustics greatly influence the neural tracking response to speech envelope, and that caution needs to be taken when choosing the control signals for speech-brain tracking analyses, considering that a slight change in acoustic parameters can have strong effects on the neural tracking response.

Abstract

Words can be distinguished by segmental differences or by suprasegmental differences or both. Studies from English suggest that suprasegmentals play little role in human spoken-word recognition; English stress, however, is nearly always unambiguously coded in segmental structure (vowel quality); this relationship is less close in Dutch. The present study directly compared the effects of segmental and suprasegmental mispronunciation on word recognition in Dutch. There was a strong effect of suprasegmental mispronunciation, suggesting that Dutch listeners do exploit suprasegmental information in word recognition. Previous findings indicating the effects of mis-stressing for Dutch differ with stress position were replicated only when segmental change was involved, suggesting that this is an effect of segmental rather than suprasegmental processing.

Abstract

Hand preference is a conspicuous variation in human behaviour, with a worldwide proportion of around 90% of people preferring to use the right hand for many tasks, and 10% the left hand. We used the large cohort of the UK biobank (~500,000 participants) to study possible relations between early life factors and adult hand preference. The probability of being left-handed was affected by the year and location of birth, likely due to cultural effects. In addition, hand preference was affected by birthweight, being part of a multiple birth, season of birth, breastfeeding, and sex, with each effect remaining significant after accounting for all others. Analysis of genome-wide genotype data showed that left-handedness was very weakly heritable, but shared no genetic basis with birthweight. Although on average left-handers and right-handers differed for a number of early life factors, all together these factors had only a minimal predictive value for individual hand preference.

Abstract

Objective:

Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically examined brain anatomical asymmetry in relation to this disorder, and results from those studies have remained inconclusive. At the functional level, some electroencephalography studies have indicated left fronto-cortical hypoactivity and right parietal hypoactivity in depressive disorders, so aspects of lateralized anatomy may also be affected. The authors used pooled individual-level data from data sets collected around the world to investigate differences in laterality in measures of cortical thickness, cortical surface area, and subcortical volume between individuals with major depression and healthy control subjects.
Methods:

The authors investigated differences in the laterality of thickness and surface area measures of 34 cerebral cortical regions in 2,256 individuals with major depression and 3,504 control subjects from 31 separate data sets, and they investigated volume asymmetries of eight subcortical structures in 2,540 individuals with major depression and 4,230 control subjects from 32 data sets. T1-weighted MRI data were processed with a single protocol using FreeSurfer and the Desikan-Killiany atlas. The large sample size provided 80% power to detect effects of the order of Cohen’s d=0.1.
Results:

The largest effect size (Cohen’s d) of major depression diagnosis was 0.085 for the thickness asymmetry of the superior temporal cortex, which was not significant after adjustment for multiple testing. Asymmetry measures were not significantly associated with medication use, acute compared with remitted status, first episode compared with recurrent status, or age at onset.
Conclusions:

Altered brain macro-anatomical asymmetry may be of little relevance to major depression etiology in most cases.

Abstract

Hand preference is a prominent behavioural trait linked to human brain asymmetry. A handful of genetic variants have been reported to associate with hand preference or quantitative measures related to it. Most of these reports were on the basis of limited sample sizes, by current standards for genetic analysis of complex traits. Here we performed a genome-wide association analysis of hand preference in the large, population-based UK Biobank cohort (N = 331,037). We used gene-set enrichment analysis to investigate whether genes involved in visceral asymmetry are particularly relevant to hand preference, following one previous report. We found no evidence supporting any of the previously suggested variants or genes, nor that genes involved in visceral laterality have a role in hand preference. It remains possible that some of the previously reported genes or pathways are relevant to hand preference as assessed in other ways, or else are relevant within specific disorder populations. However, some or all of the earlier findings are likely to be false positives, and none of them appear relevant to hand preference as defined categorically in the general population. Our analysis did produce a small number of novel, significant associations, including one implicating the microtubule-associated gene MAP2 in handedness.