Publications

Displaying 301 - 400 of 2058
  • Cozijn, R., Commandeur, E., Vonk, W., & Noordman, L. G. (2011). The time course of the use of implicit causality information in the processing of pronouns: A visual world paradigm study. Journal of Memory and Language, 64, 381-403. doi:10.1016/j.jml.2011.01.001.

    Abstract

    Several theoretical accounts have been proposed with respect to the issue how quickly the implicit causality verb bias affects the understanding of sentences such as “John beat Pete at the tennis match, because he had played very well”. They can be considered as instances of two viewpoints: the focusing and the integration account. The focusing account claims that the bias should be manifest soon after the verb has been processed, whereas the integration account claims that the interpretation is deferred until disambiguating information is encountered. Up to now, this issue has remained unresolved because materials or methods have failed to address it conclusively. We conducted two experiments that exploited the visual world paradigm and ambiguous pronouns in subordinate because clauses. The first experiment presented implicit causality sentences with the task to resolve the ambiguous pronoun. To exclude strategic processing, in the second experiment, the task was to answer simple comprehension questions and only a minority of the sentences contained implicit causality verbs. In both experiments, the implicit causality of the verb had an effect before the disambiguating information was available. This result supported the focusing account.
  • Creaghe, N., Quinn, S., & Kidd, E. (2021). Symbolic play provides a fertile context for language development. Infancy, 26(6), 980-1010. doi:10.1111/infa.12422.

    Abstract

    In this study we test the hypothesis that symbolic play represents a fertile context for language acquisition because its inherent ambiguity elicits communicative behaviours that positively influence development. Infant-caregiver dyads (N = 54) participated in two 20-minute play sessions six months apart (Time 1 = 18 months, Time 2 = 24 months). During each session the dyads played with two sets of toys that elicited either symbolic or functional play. The sessions were transcribed and coded for several features of dyadic interaction and speech; infants’ linguistic proficiency was measured via parental report. The two play contexts resulted in different communicative and linguistic behaviour. Notably, the symbolic play condition resulted in significantly greater conversational turn-taking than functional play, and also resulted in the greater use of questions and mimetics in infant-directed speech (IDS). In contrast, caregivers used more imperative clauses in functional play. Regression analyses showed that unique properties of symbolic play (i.e., turn-taking, yes-no questions, mimetics) positively predicted children’s language proficiency, whereas unique features of functional play (i.e., imperatives in IDS) negatively predicted proficiency. The results provide evidence in support of the hypothesis that symbolic play is a fertile context for language development, driven by the need to negotiate meaning.
  • Creemers, A., & Embick, D. (2021). Retrieving stem meanings in opaque words during auditory lexical processing. Language, Cognition and Neuroscience, 36(9), 1107-1122. doi:10.1080/23273798.2021.1909085.

    Abstract

    Recent constituent priming experiments show that Dutch and German prefixed verbs prime their stem, regardless of semantic transparency (e.g. Smolka et al. [(2014). ‘Verstehen’ (‘understand’) primes ‘stehen’ (‘stand’): Morphological structure overrides semantic compositionality in the lexical representation of German complex verbs. Journal of Memory and Language, 72, 16–36. https://doi.org/10.1016/j.jml.2013.12.002]). We examine whether the processing of opaque verbs (e.g. herhalen “repeat”) involves the retrieval of only the whole-word meaning, or whether the lexical-semantic meaning of the stem (halen as “take/get”) is retrieved as well. We report the results of an auditory semantic priming experiment with Dutch prefixed verbs, testing whether the recognition of a semantic associate to the stem (BRENGEN “bring”) is facilitated by the presentation of an opaque prefixed verb. In contrast to prior visual studies, significant facilitation after semantically opaque primes is found, which suggests that the lexical-semantic meaning of stems in opaque words is retrieved. We examine the implications that these findings have for auditory word recognition, and for the way in which different types of meanings are represented and processed.

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  • Cristia, A., Lavechin, M., Scaff, C., Soderstrom, M., Rowland, C. F., Räsänen, O., Bunce, J., & Bergelson, E. (2021). A thorough evaluation of the Language Environment Analysis (LENA) system. Behavior Research Methods, 53, 467-486. doi:10.3758/s13428-020-01393-5.

    Abstract

    In the previous decade, dozens of studies involving thousands of children across several research disciplines have made use of a combined daylong audio-recorder and automated algorithmic analysis called the LENAⓇ system, which aims to assess children’s language environment. While the system’s prevalence in the language acquisition domain is steadily growing, there are only scattered validation efforts on only some of its key characteristics. Here, we assess the LENAⓇ system’s accuracy across all of its key measures: speaker classification, Child Vocalization Counts (CVC), Conversational Turn Counts (CTC), and Adult Word Counts (AWC). Our assessment is based on manual annotation of clips that have been randomly or periodically sampled out of daylong recordings, collected from (a) populations similar to the system’s original training data (North American English-learning children aged 3-36 months), (b) children learning another dialect of English (UK), and (c) slightly older children growing up in a different linguistic and socio-cultural setting (Tsimane’ learners in rural Bolivia). We find reasonably high accuracy in some measures (AWC, CVC), with more problematic levels of performance in others (CTC, precision of male adults and other children). Statistical analyses do not support the view that performance is worse for children who are dissimilar from the LENAⓇ original training set. Whether LENAⓇ results are accurate enough for a given research, educational, or clinical application depends largely on the specifics at hand. We therefore conclude with a set of recommendations to help researchers make this determination for their goals.
  • Cristia, A., McGuire, G. L., Seidl, A., & Francis, A. L. (2011). Effects of the distribution of acoustic cues on infants' perception of sibilants. Journal of Phonetics, 39, 388-402. doi:10.1016/j.wocn.2011.02.004.

    Abstract

    A current theoretical view proposes that infants converge on the speech categories of their native language by attending to frequency distributions that occur in the acoustic input. To date, the only empirical support for this statistical learning hypothesis comes from studies where a single, salient dimension was manipulated. Additional evidence is sought here, by introducing a less salient pair of categories supported by multiple cues. We exposed English-learning infants to a multi-cue bidimensional grid ranging between retroflex and alveolopalatal sibilants in prevocalic position. This contrast is substantially more difficult according to previous cross-linguistic and perceptual research, and its perception is driven by cues in both the consonantal and the following vowel portions. Infants heard one of two distributions (flat, or with two peaks), and were tested with sounds varying along only one dimension. Infants' responses differed depending on the familiarization distribution, and their performance was equally good for the vocalic and the frication dimension, lending some support to the statistical hypothesis even in this harder learning situation. However, learning was restricted to the retroflex category, and a control experiment showed that lack of learning for the alveolopalatal category was not due to the presence of a competing category. Thus, these results contribute fundamental evidence on the extent and limitations of the statistical hypothesis as an explanation for infants' perceptual tuning.
  • Cristia, A. (2011). Fine-grained variation in caregivers' speech predicts their infants' discrimination. Journal of the Acoustical Society of America, 129, 3271-3280. doi:10.1121/1.3562562.

    Abstract

    Within the debate on the mechanisms underlying infants’ perceptual acquisition, one hypothesis proposes that infants’ perception is directly affected by the acoustic implementation of sound categories in the speech they hear. In consonance with this view, the present study shows that individual variation in fine-grained, subphonemic aspects of the acoustic realization of /s/ in caregivers’ speech predicts infants’ discrimination of this sound from the highly similar /∫/, suggesting that learning based on acoustic cue distributions may indeed drive natural phonological acquisition.
  • Cristia, A., Seidl, A., & Gerken, L. (2011). Learning classes of sounds in infancy. University of Pennsylvania Working Papers in Linguistics, 17, 9.

    Abstract

    Adults' phonotactic learning is affected by perceptual biases. One such bias concerns learning of constraints affecting groups of sounds: all else being equal, learning constraints affecting a natural class (a set of sounds sharing some phonetic characteristic) is easier than learning a constraint affecting an arbitrary set of sounds. This perceptual bias could be a given, for example, the result of innately guided learning; alternatively, it could be due to human learners’ experience with sounds. Using artificial grammars, we investigated whether such a bias arises in development, or whether it is present as soon as infants can learn phonotactics. Seven-month-old English-learning infants fail to generalize a phonotactic pattern involving fricatives and nasals, which does not form a coherent phonetic group, but succeed with the natural class of oral and nasal stops. In this paper, we report an experiment that explored whether those results also follow in a cohort of 4-month-olds. Unlike the older infants, 4-month-olds were able to generalize both groups, suggesting that the perceptual bias that makes phonotactic constraints on natural classes easier to learn is likely the effect of experience.
  • Cristia, A., Seidl, A., & Francis, A. L. (2011). Phonological features in infancy. In G. N. Clements, & R. Ridouane (Eds.), Where do phonological contrasts come from? Cognitive, physical and developmental bases of phonological features (pp. 303-326). Amsterdam: Benjamins.

    Abstract

    Features serve two main functions in the phonology of languages: they encode the distinction between pairs of contrastive phonemes (distinctive function); and they delimit sets of sounds that participate in phonological processes and patterns (classificatory function). We summarize evidence from a variety of experimental paradigms bearing on the functional relevance of phonological features. This research shows that while young infants may use abstract phonological features to learn sound patterns, this ability becomes more constrained with development and experience. Furthermore, given the lack of overlap between the ability to learn a pair of words differing in a single feature and the ability to learn sound patterns based on features, we argue for the separation of the distinctive and the classificatory function.
  • Cristia, A., & Seidl, A. (2011). Sensitivity to prosody at 6 months predicts vocabulary at 24 months. In N. Danis, K. Mesh, & H. Sung (Eds.), BUCLD 35: Proceedings of the 35th annual Boston University Conference on Language Development (pp. 145-156). Somerville, Mass: Cascadilla Press.
  • Croijmans, I. (2016). Gelukkig kunnen we erover praten: Over de kunst om geuren en smaken in woorden te omschrijven. koffieTcacao, 17, 80-81.
  • Croijmans, I., & Majid, A. (2016). Language does not explain the wine-specific memory advantage of wine experts. In A. Papafragou, D. Grodner, D. Mirman, & J. Trueswell (Eds.), Proceedings of the 38th Annual Meeting of the Cognitive Science Society (CogSci 2016) (pp. 141-146). Austin, TX: Cognitive Science Society.

    Abstract

    Although people are poor at naming odors, naming a smell helps to remember that odor. Previous studies show wine experts have better memory for smells, and they also name smells differently than novices. Is wine experts’ odor memory is verbally mediated? And is the odor memory advantage that experts have over novices restricted to odors in their domain of expertise, or does it generalize? Twenty-four wine experts and 24 novices smelled wines, wine-related odors and common odors, and remembered these. Half the participants also named the smells. Wine experts had better memory for wines, but not for the other odors, indicating their memory advantage is restricted to wine. Wine experts named odors better than novices, but there was no relationship between experts’ ability to name odors and their memory for odors. This suggests experts’ odor memory advantage is not linguistically mediated, but may be the result of differential perceptual learning
  • Croijmans, I., & Majid, A. (2016). Not all flavor expertise is equal: The language of wine and coffee experts. PLoS One, 11(6): e0155845. doi:10.1371/journal.pone.0155845.

    Abstract

    People in Western cultures are poor at naming smells and flavors. However, for wine and
    coffee experts, describing smells and flavors is part of their daily routine. So are experts bet-
    ter than lay people at conveying smells and flavors in language? If smells and flavors are
    more easily linguistically expressed by experts, or more

    codable

    , then experts should be
    better than novices at describing smells and flavors. If experts are indeed better, we can
    also ask how general this advantage is: do experts show higher codability only for smells
    and flavors they are expert in (i.e., wine experts for wine and coffee experts for coffee) or is
    their linguistic dexterity more general? To address these questions, wine experts, coffee
    experts, and novices were asked to describe the smell and flavor of wines, coffees, every-
    day odors, and basic tastes. The resulting descriptions were compared on a number of
    measures. We found expertise endows a modest advantage in smell and flavor naming.
    Wine experts showed more consistency in how they described wine smells and flavors than
    coffee experts, and novices; but coffee experts were not more consistent for coffee descriptions. Neither expert group was any more accurate at identifying everyday smells or tastes. Interestingly, both wine and coffee experts tended to use more source-based terms (e.g., vanilla) in descriptions of their own area of expertise whereas novices tended to use more
    evaluative terms (e.g.,nice). However, the overall linguistic strategies for both groups were en par. To conclude, experts only have a limited, domain-specific advantage when communicating about smells and flavors. The ability to communicate about smells and flavors is a matter not only of perceptual training, but specific linguistic training too

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  • Cronin, K. A., Van Leeuwen, E. J. C., Mulenga, I. C., & Bodamer, M. D. (2011). Behavioral response of a chimpanzee mother toward her dead infant. American Journal of Primatology, 73(5), 415-421. doi:10.1002/ajp.20927.

    Abstract

    The mother-offspring bond is one of the strongest and most essential social bonds. Following is a detailed behavioral report of a female chimpanzee two days after her 16-month-old infant died, on the first day that the mother is observed to create distance between her and the corpse. A series of repeated approaches and retreats to and from the body are documented, along with detailed accounts of behaviors directed toward the dead infant by the mother and other group members. The behavior of the mother toward her dead infant not only highlights the maternal contribution to the mother-infant relationship but also elucidates the opportunities chimpanzees have to learn about the sensory cues associated with death, and the implications of death for the social environment.
  • Cronin, K. A., West, V., & Ross, S. R. (2016). Investigating the Relationship between Welfare and Rearing Young in Captive Chimpanzees (Pan troglodytes). Applied Animal Behaviour Science, 181, 166-172. doi:10.1016/j.applanim.2016.05.014.

    Abstract

    Whether the opportunity to breed and rear young improves the welfare of captive animals is currently debated. However, there is very little empirical data available to evaluate this relationship and this study is a first attempt to contribute objective data to this debate. We utilized the existing variation in the reproductive experiences of sanctuary chimpanzees at Chimfunshi Wildlife Orphanage Trust in Zambia to investigate whether breeding and rearing young was associated with improved welfare for adult females (N = 43). We considered several behavioural welfare indicators, including rates of luxury behaviours and abnormal or stress-related behaviours under normal conditions and conditions inducing social stress. Furthermore, we investigated whether spending time with young was associated with good or poor welfare for adult females, regardless of their kin relationship. We used generalized linear mixed models and found no difference between adult females with and without dependent young on any welfare indices, nor did we find that time spent in proximity to unrelated young predicted welfare (all full-null model comparisons likelihood ratio tests P > 0.05). However, we did find that coprophagy was more prevalent among mother-reared than non-mother-reared individuals, in line with recent work suggesting this behaviour may have a different etiology than other behaviours often considered to be abnormal. In sum, the findings from this initial study lend support to the hypothesis that the opportunity to breed and rear young does not provide a welfare benefit for chimpanzees in captivity. We hope this investigation provides a valuable starting point for empirical study into the welfare implications of managed breeding.

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  • Cuellar-Partida, G., Tung, J. Y., Eriksson, N., Albrecht, E., Aliev, F., Andreassen, O. A., Barroso, I., Beckmann, J. S., Boks, M. P., Boomsma, D. I., Boyd, H. A., Breteler, M. M. B., Campbell, H., Chasman, D. I., Cherkas, L. F., Davies, G., De Geus, E. J. C., Deary, I. J., Deloukas, P., Dick, D. M. and 98 moreCuellar-Partida, G., Tung, J. Y., Eriksson, N., Albrecht, E., Aliev, F., Andreassen, O. A., Barroso, I., Beckmann, J. S., Boks, M. P., Boomsma, D. I., Boyd, H. A., Breteler, M. M. B., Campbell, H., Chasman, D. I., Cherkas, L. F., Davies, G., De Geus, E. J. C., Deary, I. J., Deloukas, P., Dick, D. M., Duffy, D. L., Eriksson, J. G., Esko, T., Feenstra, B., Geller, F., Gieger, C., Giegling, I., Gordon, S. D., Han, J., Hansen, T. F., Hartmann, A. M., Hayward, C., Heikkilä, K., Hicks, A. A., Hirschhorn, J. N., Hottenga, J.-J., Huffman, J. E., Hwang, L.-D., Ikram, M. A., Kaprio, J., Kemp, J. P., Khaw, K.-T., Klopp, N., Konte, B., Kutalik, Z., Lahti, J., Li, X., Loos, R. J. F., Luciano, M., Magnusson, S. H., Mangino, M., Marques-Vidal, P., Martin, N. G., McArdle, W. L., McCarthy, M. I., Medina-Gomez, C., Melbye, M., Melville, S. A., Metspalu, A., Milani, L., Mooser, V., Nelis, M., Nyholt, D. R., O'Connell, K. S., Ophoff, R. A., Palmer, C., Palotie, A., Palviainen, T., Pare, G., Paternoster, L., Peltonen, L., Penninx, B. W. J. H., Polasek, O., Pramstaller, P. P., Prokopenko, I., Raikkonen, K., Ripatti, S., Rivadeneira, F., Rudan, I., Rujescu, D., Smit, J. H., Smith, G. D., Smoller, J. W., Soranzo, N., Spector, T. D., St Pourcain, B., Starr, J. M., Stefánsson, H., Steinberg, S., Teder-Laving, M., Thorleifsson, G., Stefansson, K., Timpson, N. J., Uitterlinden, A. G., Van Duijn, C. M., Van Rooij, F. J. A., Vink, J. M., Vollenweider, P., Vuoksimaa, E., Waeber, G., Wareham, N. J., Warrington, N., Waterworth, D., Werge, T., Wichmann, H.-E., Widen, E., Willemsen, G., Wright, A. F., Wright, M. J., Xu, M., Zhao, J. H., Kraft, P., Hinds, D. A., Lindgren, C. M., Magi, R., Neale, B. M., Evans, D. M., & Medland, S. E. (2021). Genome-wide association study identifies 48 common genetic variants associated with handedness. Nature Human Behaviour, 5, 59-70. doi:10.1038/s41562-020-00956-y.

    Abstract

    Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10−8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.

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  • Cutler, A., Norris, D., & Sebastián-Gallés, N. (2004). Phonemic repertoire and similarity within the vocabulary. In S. Kin, & M. J. Bae (Eds.), Proceedings of the 8th International Conference on Spoken Language Processing (Interspeech 2004-ICSLP) (pp. 65-68). Seoul: Sunjijn Printing Co.

    Abstract

    Language-specific differences in the size and distribution of the phonemic repertoire can have implications for the task facing listeners in recognising spoken words. A language with more phonemes will allow shorter words and reduced embedding of short words within longer ones, decreasing the potential for spurious lexical competitors to be activated by speech signals. We demonstrate that this is the case via comparative analyses of the vocabularies of English and Spanish. A language which uses suprasegmental as well as segmental contrasts, however, can substantially reduce the extent of spurious embedding.
  • Cutler, A. (2004). Segmentation of spoken language by normal adult listeners. In R. Kent (Ed.), MIT encyclopedia of communication sciences and disorders (pp. 392-395). Cambridge, MA: MIT Press.
  • Cutler, A., Weber, A., Smits, R., & Cooper, N. (2004). Patterns of English phoneme confusions by native and non-native listeners. Journal of the Acoustical Society of America, 116(6), 3668-3678. doi:10.1121/1.1810292.

    Abstract

    Native American English and non-native(Dutch)listeners identified either the consonant or the vowel in all possible American English CV and VC syllables. The syllables were embedded in multispeaker babble at three signal-to-noise ratios(0, 8, and 16 dB). The phoneme identification
    performance of the non-native listeners was less accurate than that of the native listeners. All listeners were adversely affected by noise. With these isolated syllables, initial segments were harder to identify than final segments. Crucially, the effects of language background and noise did not interact; the performance asymmetry between the native and non-native groups was not significantly different across signal-to-noise ratios. It is concluded that the frequently reported disproportionate difficulty of non-native listening under disadvantageous conditions is not due to a disproportionate increase in phoneme misidentifications.
  • Cutler, A. (2004). On spoken-word recognition in a second language. Newsletter, American Association of Teachers of Slavic and East European Languages, 47, 15-15.
  • Cutler, A., & Henton, C. G. (2004). There's many a slip 'twixt the cup and the lip. In H. Quené, & V. Van Heuven (Eds.), On speech and Language: Studies for Sieb G. Nooteboom (pp. 37-45). Utrecht: Netherlands Graduate School of Linguistics.

    Abstract

    The retiring academic may look back upon, inter alia, years of conference attendance. Speech error researchers are uniquely fortunate because they can collect data in any situation involving communication; accordingly, the retiring speech error researcher will have collected data at those conferences. We here address the issue of whether error data collected in situations involving conviviality (such as at conferences) is representative of error data in general. Our approach involved a comparison, across three levels of linguistic processing, between a specially constructed Conviviality Sample and the largest existing source of speech error data, the newly available Fromkin Speech Error Database. The results indicate that there are grounds for regarding the data in the Conviviality Sample as a better than average reflection of the true population of all errors committed. These findings encourage us to recommend further data collection in collaboration with like-minded colleagues.
  • Cutler, A. (2004). Twee regels voor academische vorming. In H. Procee (Ed.), Bij die wereld wil ik horen! Zesendertig columns en drie essays over de vorming tot academicus. (pp. 42-45). Amsterdam: Boom.
  • Cutler, A., & Jesse, A. (2021). Word stress in speech perception. In J. S. Pardo, L. C. Nygaard, & D. B. Pisoni (Eds.), The handbook of speech perception (2nd ed., pp. 239-265). Chichester: Wiley.
  • Cutler, A., Aslin, R. N., Gervain, J., & Nespor, M. (Eds.). (2021). Special issue in honor of Jacques Mehler, Cognition's founding editor [Special Issue]. Cognition, 213.
  • Cutler, A., Aslin, R. N., Gervain, J., & Nespor, M. (2021). Special issue in honor of Jacques Mehler, Cognition's founding editor [preface]. Cognition, 213: 104786. doi:10.1016/j.cognition.2021.104786.
  • Cutler, A., & Norris, D. (2016). Bottoms up! How top-down pitfalls ensnare speech perception researchers too. Commentary on C. Firestone & B. Scholl: Cognition does not affect perception: Evaluating the evidence for 'top-down' effects. Behavioral and Brain Sciences, e236. doi:10.1017/S0140525X15002745.

    Abstract

    Not only can the pitfalls that Firestone & Scholl (F&S) identify be generalised across multiple studies within the field of visual perception, but also they have general application outside the field wherever perceptual and cognitive processing are compared. We call attention to the widespread susceptibility of research on the perception of speech to versions of the same pitfalls.
  • Cutler, A., Sebastian-Galles, N., Soler-Vilageliu, O., & Van Ooijen, B. (2000). Constraints of vowels and consonants on lexical selection: Cross-linguistic comparisons. Memory & Cognition, 28, 746-755.

    Abstract

    Languages differ in the constitution of their phonemic repertoire and in the relative distinctiveness of phonemes within the repertoire. In the present study, we asked whether such differences constrain spoken-word recognition, via two word reconstruction experiments, in which listeners turned non-words into real words by changing single sounds. The experiments were carried out in Dutch (which has a relatively balanced vowel-consonant ratio and many similar vowels) and in Spanish (which has many more consonants than vowels and high distinctiveness among the vowels). Both Dutch and Spanish listeners responded significantly faster and more accurately when required to change vowels as opposed to consonants; when allowed to change any phoneme, they more often altered vowels than consonants. Vowel information thus appears to constrain lexical selection less tightly (allow more potential candidates) than does consonant information, independent of language-specific phoneme repertoire and of relative distinctiveness of vowels.
  • Ip, M., & Cutler, A. (2016). Cross-language data on five types of prosodic focus. In J. Barnes, A. Brugos, S. Shattuck-Hufnagel, & N. Veilleux (Eds.), Proceedings of Speech Prosody 2016 (pp. 330-334).

    Abstract

    To examine the relative roles of language-specific and language-universal mechanisms in the production of prosodic focus, we compared production of five different types of focus by native speakers of English and Mandarin. Two comparable dialogues were constructed for each language, with the same words appearing in focused and unfocused position; 24 speakers recorded each dialogue in each language. Duration, F0 (mean, maximum, range), and rms-intensity (mean, maximum) of all critical word tokens were measured. Across the different types of focus, cross-language differences were observed in the degree to which English versus Mandarin speakers use the different prosodic parameters to mark focus, suggesting that while prosody may be universally available for expressing focus, the means of its employment may be considerably language-specific
  • Cutler, A. (1992). Cross-linguistic differences in speech segmentation. MRC News, 56, 8-9.
  • Cutler, A., & Van de Weijer, J. (2000). De ontdekking van de eerste woorden. Stem-, Spraak- en Taalpathologie, 9, 245-259.

    Abstract

    Spraak is continu, er zijn geen betrouwbare signalen waardoor de luisteraar weet waar het ene woord eindigt en het volgende begint. Voor volwassen luisteraars is het segmenteren van gesproken taal in afzonderlijke woorden dus niet onproblematisch, maar voor een kind dat nog geen woordenschat bezit, vormt de continuïteit van spraak een nog grotere uitdaging. Desalniettemin produceren de meeste kinderen hun eerste herkenbare woorden rond het begin van het tweede levensjaar. Aan deze vroege spraakproducties gaat een formidabele perceptuele prestatie vooraf. Tijdens het eerste levensjaar - met name gedurende de tweede helft - ontwikkelt de spraakperceptie zich van een algemeen fonetisch discriminatievermogen tot een selectieve gevoeligheid voor de fonologische contrasten die in de moedertaal voorkomen. Recent onderzoek heeft verder aangetoond dat kinderen, lang voordat ze ook maar een enkel woord kunnen zeggen, in staat zijn woorden die kenmerkend zijn voor hun moedertaal te onderscheiden van woorden die dat niet zijn. Bovendien kunnen ze woorden die eerst in isolatie werden aangeboden herkennen in een continue spraakcontext. Het dagelijkse taalaanbod aan een kind van deze leeftijd maakt het in zekere zin niet gemakkelijk, bijvoorbeeld doordat de meeste woorden niet in isolatie voorkomen. Toch wordt het kind ook wel houvast geboden, onder andere doordat het woordgebruik beperkt is.
  • Cutler, A., & Butterfield, S. (1990). Durational cues to word boundaries in clear speech. Speech Communication, 9, 485-495.

    Abstract

    One of a listener’s major tasks in understanding continuous speech in segmenting the speech signal into separate words. When listening conditions are difficult, speakers can help listeners by deliberately clear speech. We found that speakers do indeed attempt to makr word boundaries; moreover, they differentiate between word boundaries in a way which suggest they are sensitive to listener needs. Application of heuristic segmentation strategies makes word boundaries before strong syllables easiest for listeners to perceive; but under difficult listening conditions speakers pay more attention to marking word boundaries before weak syllables, i.e. they mark those boundaries which are otherwise particularly hard to perceive.
  • Cutler, A., McQueen, J. M., & Robinson, K. (1990). Elizabeth and John: Sound patterns of men’s and women’s names. Journal of Linguistics, 26, 471-482. doi:10.1017/S0022226700014754.
  • Cutler, A., & Norris, D. (1992). Detection of vowels and consonants with minimal acoustic variation. Speech Communication, 11, 101-108. doi:10.1016/0167-6393(92)90004-Q.

    Abstract

    Previous research has shown that, in a phoneme detection task, vowels produce longer reaction times than consonants, suggesting that they are harder to perceive. One possible explanation for this difference is based upon their respective acoustic/articulatory characteristics. Another way of accounting for the findings would be to relate them to the differential functioning of vowels and consonants in the syllabic structure of words. In this experiment, we examined the second possibility. Targets were two pairs of phonemes, each containing a vowel and a consonant with similar phonetic characteristics. Subjects heard lists of English words had to press a response key upon detecting the occurrence of a pre-specified target. This time, the phonemes which functioned as vowels in syllabic structure yielded shorter reaction times than those which functioned as consonants. This rules out an explanation for response time difference between vowels and consonants in terms of function in syllable structure. Instead, we propose that consonantal and vocalic segments differ with respect to variability of tokens, both in the acoustic realisation of targets and in the representation of targets by listeners.
  • Cutler, A., Wales, R., Cooper, N., & Janssen, J. (2007). Dutch listeners' use of suprasegmental cues to English stress. In J. Trouvain, & W. J. Barry (Eds.), Proceedings of the 16th International Congress of Phonetics Sciences (ICPhS 2007) (pp. 1913-1916). Dudweiler: Pirrot.

    Abstract

    Dutch listeners outperform native listeners in identifying syllable stress in English. This is because lexical stress is more useful in recognition of spoken words of Dutch than of English, so that Dutch listeners pay greater attention to stress in general. We examined Dutch listeners’ use of the acoustic correlates of English stress. Primary- and secondary-stressed syllables differ significantly on acoustic measures, and some differences, in F0 especially, correlate with data of earlier listening experiments. The correlations found in the Dutch responses were not paralleled in data from native listeners. Thus the acoustic cues which distinguish English primary versus secondary stress are better exploited by Dutch than by native listeners.
  • Cutler, A., & Weber, A. (2007). Listening experience and phonetic-to-lexical mapping in L2. In J. Trouvain, & W. J. Barry (Eds.), Proceedings of the 16th International Congress of Phonetic Sciences (ICPhS 2007) (pp. 43-48). Dudweiler: Pirrot.

    Abstract

    In contrast to initial L1 vocabularies, which of necessity depend largely on heard exemplars, L2 vocabulary construction can draw on a variety of knowledge sources. This can lead to richer stored knowledge about the phonology of the L2 than the listener's prelexical phonetic processing capacity can support, and thus to mismatch between the level of detail required for accurate lexical mapping and the level of detail delivered by the prelexical processor. Experiments on spoken word recognition in L2 have shown that phonetic contrasts which are not reliably perceived are represented in the lexicon nonetheless. This lexical representation of contrast must be based on abstract knowledge, not on veridical representation of heard exemplars. New experiments confirm that provision of abstract knowledge (in the form of spelling) can induce lexical representation of a contrast which is not reliably perceived; but also that experience (in the form of frequency of occurrence) modulates the mismatch of phonetic and lexical processing. We conclude that a correct account of word recognition in L2 (as indeed in L1) requires consideration of both abstract and episodic information.
  • Cutler, A., Cooke, M., Garcia-Lecumberri, M. L., & Pasveer, D. (2007). L2 consonant identification in noise: Cross-language comparisons. In H. van Hamme, & R. van Son (Eds.), Proceedings of Interspeech 2007 (pp. 1585-1588). Adelaide: Causal productions.

    Abstract

    The difficulty of listening to speech in noise is exacerbated when the speech is in the listener’s L2 rather than L1. In this study, Spanish and Dutch users of English as an L2 identified American English consonants in a constant intervocalic context. Their performance was compared with that of L1 (British English) listeners, under quiet conditions and when the speech was masked by speech from another talker or by noise. Masking affected performance more for the Spanish listeners than for the L1 listeners, but not for the Dutch listeners, whose performance was worse than the L1 case to about the same degree in all conditions. There were, however,large differences in the pattern of results across individual consonants, which were consistent with differences in how consonants are identified in the respective L1s.
  • Cutler, A., Mister, E., Norris, D., & Sebastián-Gallés, N. (2004). La perception de la parole en espagnol: Un cas particulier? In L. Ferrand, & J. Grainger (Eds.), Psycholinguistique cognitive: Essais en l'honneur de Juan Segui (pp. 57-74). Brussels: De Boeck.
  • Cutler, A. (1990). From performance to phonology: Comments on Beckman and Edwards's paper. In J. Kingston, & M. Beckman (Eds.), Papers in laboratory phonology I: Between the grammar and physics of speech (pp. 208-214). Cambridge: Cambridge University Press.
  • Cutler, A. (2000). How the ear comes to hear. In New Trends in Modern Linguistics [Part of Annual catalogue series] (pp. 6-10). Tokyo, Japan: Maruzen Publishers.
  • Cutler, A., Andics, A., & Fang, Z. (2011). Inter-dependent categorization of voices and segments. In W.-S. Lee, & E. Zee (Eds.), Proceedings of the 17th International Congress of Phonetic Sciences [ICPhS 2011] (pp. 552-555). Hong Kong: Department of Chinese, Translation and Linguistics, City University of Hong Kong.

    Abstract

    Listeners performed speeded two-alternative choice between two unfamiliar and relatively similar voices or between two phonetically close segments, in VC syllables. For each decision type (segment, voice), the non-target dimension (voice, segment) either was constant, or varied across four alternatives. Responses were always slower when a non-target dimension varied than when it did not, but the effect of phonetic variation on voice identity decision was stronger than that of voice variation on phonetic identity decision. Cues to voice and segment identity in speech are processed inter-dependently, but hard categorization decisions about voices draw on, and are hence sensitive to, segmental information.
  • Cutler, A. (2000). Hoe het woord het oor verovert. In Voordrachten uitgesproken tijdens de uitreiking van de SPINOZA-premies op 15 februari 2000 (pp. 29-41). The Hague, The Netherlands: Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO).
  • Cutler, A., Mehler, J., Norris, D., & Segui, J. (1988). Limits on bilingualism [Letters to Nature]. Nature, 340, 229-230. doi:10.1038/340229a0.

    Abstract

    SPEECH, in any language, is continuous; speakers provide few reliable cues to the boundaries of words, phrases, or other meaningful units. To understand speech, listeners must divide the continuous speech stream into portions that correspond to such units. This segmentation process is so basic to human language comprehension that psycholinguists long assumed that all speakers would do it in the same way. In previous research1,2, however, we reported that segmentation routines can be language-specific: speakers of French process spoken words syllable by syllable, but speakers of English do not. French has relatively clear syllable boundaries and syllable-based timing patterns, whereas English has relatively unclear syllable boundaries and stress-based timing; thus syllabic segmentation would work more efficiently in the comprehension of French than in the comprehension of English. Our present study suggests that at this level of language processing, there are limits to bilingualism: a bilingual speaker has one and only one basic language.
  • Cutler, A., Kearns, R., Norris, D., & Scott, D. (1992). Listeners’ responses to extraneous signals coincident with English and French speech. In J. Pittam (Ed.), Proceedings of the 4th Australian International Conference on Speech Science and Technology (pp. 666-671). Canberra: Australian Speech Science and Technology Association.

    Abstract

    English and French listeners performed two tasks - click location and speeded click detection - with both English and French sentences, closely matched for syntactic and phonological structure. Clicks were located more accurately in open- than in closed-class words in both English and French; they were detected more rapidly in open- than in closed-class words in English, but not in French. The two listener groups produced the same pattern of responses, suggesting that higher-level linguistic processing was not involved in these tasks.
  • Cutler, A. (2011). Listening to REAL second language. AATSEEL Newsletter, 54(3), 14.
  • Cutler, A. (1990). Exploiting prosodic probabilities in speech segmentation. In G. Altmann (Ed.), Cognitive models of speech processing: Psycholinguistic and computational perspectives (pp. 105-121). Cambridge, MA: MIT Press.
  • Cutler, A., & Chen, H.-C. (1995). Phonological similarity effects in Cantonese word recognition. In K. Elenius, & P. Branderud (Eds.), Proceedings of the Thirteenth International Congress of Phonetic Sciences: Vol. 1 (pp. 106-109). Stockholm: Stockholm University.

    Abstract

    Two lexical decision experiments in Cantonese are described in which the recognition of spoken target words as a function of phonological similarity to a preceding prime is investigated. Phonological similaritv in first syllables produced inhibition, while similarity in second syllables led to facilitation. Differences between syllables in tonal and segmental structure had generally similar effects.
  • Cutler, A., McQueen, J. M., & Zondervan, R. (2000). Proceedings of SWAP (Workshop on Spoken Word Access Processes). Nijmegen: MPI for Psycholinguistics.
  • Cutler, A. (1992). Proceedings with confidence. New Scientist, (1825), 54.
  • Cutler, A. (1992). Processing constraints of the native phonological repertoire on the native language. In Y. Tohkura, E. Vatikiotis-Bateson, & Y. Sagisaka (Eds.), Speech perception, production and linguistic structure (pp. 275-278). Tokyo: Ohmsha.
  • Cutler, A. (1992). Psychology and the segment. In G. Docherty, & D. Ladd (Eds.), Papers in laboratory phonology II: Gesture, segment, prosody (pp. 290-295). Cambridge: Cambridge University Press.
  • Cutler, A. (2000). Real words, phantom words and impossible words. In D. Burnham, S. Luksaneeyanawin, C. Davis, & M. Lafourcade (Eds.), Interdisciplinary approaches to language processing: The international conference on human and machine processing of language and speech (pp. 32-42). Bangkok: NECTEC.
  • Cutler, A., & Scott, D. R. (1990). Speaker sex and perceived apportionment of talk. Applied Psycholinguistics, 11, 253-272. doi:10.1017/S0142716400008882.

    Abstract

    It is a widely held belief that women talk more than men; but experimental evidence has suggested that this belief is mistaken. The present study investigated whether listener bias contributes to this mistake. Dialogues were recorded in mixed-sex and single-sex versions, and male and female listeners judged the proportions of talk contributed to the dialogues by each participant. Female contributions to mixed-sex dialogues were rated as greater than male contributions by both male and female listeners. Female contributions were more likely to be overestimated when they were speaking a dialogue part perceived as probably female than when they were speaking a dialogue part perceived as probably male. It is suggested that the misestimates are due to a complex of factors that may involve both perceptual effects such as misjudgment of rates of speech and sociological effects such as attitudes to social roles and perception of power relations.
  • Cutler, A. (1995). Spoken word recognition and production. In J. L. Miller, & P. D. Eimas (Eds.), Speech, language and communication (pp. 97-136). New York: Academic Press.

    Abstract

    This chapter highlights that most language behavior consists of speaking and listening. The chapter also reveals differences and similarities between speaking and listening. The laboratory study of word production raises formidable problems; ensuring that a particular word is produced may subvert the spontaneous production process. Word production is investigated via slips and tip-of-the-tongue (TOT), primarily via instances of processing failure and via the technique of via the picture-naming task. The methodology of word production is explained in the chapter. The chapter also explains the phenomenon of interaction between various stages of word production and the process of speech recognition. In this context, it explores the difference between sound and meaning and examines whether or not the comparisons are appropriate between the processes of recognition and production of spoken words. It also describes the similarities and differences in the structure of the recognition and production systems. Finally, the chapter highlights the common issues in recognition and production research, which include the nuances of frequency of occurrence, morphological structure, and phonological structure.
  • Cutler, A. (1995). Spoken-word recognition. In G. Bloothooft, V. Hazan, D. Hubert, & J. Llisterri (Eds.), European studies in phonetics and speech communication (pp. 66-71). Utrecht: OTS.
  • Cutler, A., & Koster, M. (2000). Stress and lexical activation in Dutch. In B. Yuan, T. Huang, & X. Tang (Eds.), Proceedings of the Sixth International Conference on Spoken Language Processing: Vol. 1 (pp. 593-596). Beijing: China Military Friendship Publish.

    Abstract

    Dutch listeners were slower to make judgements about the semantic relatedness between a spoken target word (e.g. atLEET, 'athlete') and a previously presented visual prime word (e.g. SPORT 'sport') when the spoken word was mis-stressed. The adverse effect of mis-stressing confirms the role of stress information in lexical recognition in Dutch. However, although the erroneous stress pattern was always initially compatible with a competing word (e.g. ATlas, 'atlas'), mis-stressed words did not produced high false alarm rates in unrelated pairs (e.g. SPORT - atLAS). This suggests that stress information did not completely rule out segmentally matching but suprasegmentally mismatching words, a finding consistent with spoken-word recognition models involving multiple activation and inter-word competition.
  • Cutler, A. (1990). Syllabic lengthening as a word boundary cue. In R. Seidl (Ed.), Proceedings of the 3rd Australian International Conference on Speech Science and Technology (pp. 324-328). Canberra: Australian Speech Science and Technology Association.

    Abstract

    Bisyllabic sequences which could be interpreted as one word or two were produced in sentence contexts by a trained speaker, and syllabic durations measured. Listeners judged whether the bisyllables, excised from context, were one word or two. The proportion of two-word choices correlated positively with measured duration, but only for bisyllables stressed on the second syllable. The results may suggest a limit for listener sensitivity to syllabic lengthening as a word boundary cue.
  • Cutler, A., & Robinson, T. (1992). Response time as a metric for comparison of speech recognition by humans and machines. In J. Ohala, T. Neary, & B. Derwing (Eds.), Proceedings of the Second International Conference on Spoken Language Processing: Vol. 1 (pp. 189-192). Alberta: University of Alberta.

    Abstract

    The performance of automatic speech recognition systems is usually assessed in terms of error rate. Human speech recognition produces few errors, but relative difficulty of processing can be assessed via response time techniques. We report the construction of a measure analogous to response time in a machine recognition system. This measure may be compared directly with human response times. We conducted a trial comparison of this type at the phoneme level, including both tense and lax vowels and a variety of consonant classes. The results suggested similarities between human and machine processing in the case of consonants, but differences in the case of vowels.
  • Cutler, A., & Butterfield, S. (1992). Rhythmic cues to speech segmentation: Evidence from juncture misperception. Journal of Memory and Language, 31, 218-236. doi:10.1016/0749-596X(92)90012-M.

    Abstract

    Segmentation of continuous speech into its component words is a nontrivial task for listeners. Previous work has suggested that listeners develop heuristic segmentation procedures based on experience with the structure of their language; for English, the heuristic is that strong syllables (containing full vowels) are most likely to be the initial syllables of lexical words, whereas weak syllables (containing central, or reduced, vowels) are nonword-initial, or, if word-initial, are grammatical words. This hypothesis is here tested against natural and laboratory-induced missegmentations of continuous speech. Precisely the expected pattern is found: listeners erroneously insert boundaries before strong syllables but delete them before weak syllables; boundaries inserted before strong syllables produce lexical words, while boundaries inserted before weak syllables produce grammatical words.
  • Cutler, A. (1995). The perception of rhythm in spoken and written language. In J. Mehler, & S. Franck (Eds.), Cognition on cognition (pp. 283-288). Cambridge, MA: MIT Press.
  • Cutler, A. (1992). The perception of speech: Psycholinguistic aspects. In W. Bright (Ed.), International encyclopedia of language: Vol. 3 (pp. 181-183). New York: Oxford University Press.
  • Cutler, A. (1988). The perfect speech error. In L. Hyman, & C. Li (Eds.), Language, speech and mind: Studies in honor of Victoria A. Fromkin (pp. 209-223). London: Croom Helm.
  • Cutler, A. (1992). The production and perception of word boundaries. In Y. Tohkura, E. Vatikiotis-Bateson, & Y. Sagisaka (Eds.), Speech perception, production and linguistic structure (pp. 419-425). Tokyo: Ohsma.
  • Cutler, A., & McQueen, J. M. (1995). The recognition of lexical units in speech. In B. De Gelder, & J. Morais (Eds.), Speech and reading: A comparative approach (pp. 33-47). Hove, UK: Erlbaum.
  • Cutler, A., & Norris, D. (1988). The role of strong syllables in segmentation for lexical access. Journal of Experimental Psychology: Human Perception and Performance, 14, 113-121. doi:10.1037/0096-1523.14.1.113.

    Abstract

    A model of speech segmentation in a stress language is proposed, according to which the occurrence of a strong syllable triggers segmentation of the speech signal, whereas occurrence of a weak syllable does not trigger segmentation. We report experiments in which listeners detected words embedded in nonsense bisyllables more slowly when the bisyllable had two strong syllables than when it had a strong and a weak syllable; mint was detected more slowly in mintayve than in mintesh. According to our proposed model, this result is an effect of segmentation: When the second syllable is strong, it is segmented from the first syllable, and successful detection of the embedded word therefore requires assembly of speech material across a segmentation position. Speech recognition models involving phonemic or syllabic recoding, or based on strictly left-to-right processes, do not predict this result. It is argued that segmentation at strong syllables in continuous speech recognition serves the purpose of detecting the most efficient locations at which to initiate lexical access. (C) 1988 by the American Psychological Association
  • Cutler, A., Mehler, J., Norris, D., & Segui, J. (1992). The monolingual nature of speech segmentation by bilinguals. Cognitive Psychology, 24, 381-410.

    Abstract

    Monolingual French speakers employ a syllable-based procedure in speech segmentation; monolingual English speakers use a stress-based segmentation procedure and do not use the syllable-based procedure. In the present study French-English bilinguals participated in segmentation experiments with English and French materials. Their results as a group did not simply mimic the performance of English monolinguals with English language materials and of French monolinguals with French language materials. Instead, the bilinguals formed two groups, defined by forced choice of a dominant language. Only the French-dominant group showed syllabic segmentation and only with French language materials. The English-dominant group showed no syllabic segmentation in either language. However, the English-dominant group showed stress-based segmentation with English language materials; the French-dominant group did not. We argue that rhythmically based segmentation procedures are mutually exclusive, as a consequence of which speech segmentation by bilinguals is, in one respect at least, functionally monolingual.
  • Cutler, A., Norris, D., & Van Ooijen, B. (1990). Vowels as phoneme detection targets. In Proceedings of the First International Conference on Spoken Language Processing (pp. 581-584).

    Abstract

    Phoneme detection is a psycholinguistic task in which listeners' response time to detect the presence of a pre-specified phoneme target is measured. Typically, detection tasks have used consonant targets. This paper reports two experiments in which subjects responded to vowels as phoneme detection targets. In the first experiment, targets occurred in real words, in the second in nonsense words. Response times were long by comparison with consonantal targets. Targets in initial syllables were responded to much more slowly than targets in second syllables. Strong vowels were responded to faster than reduced vowels in real words but not in nonwords. These results suggest that the process of phoneme detection produces different results for vowels and for consonants. We discuss possible explanations for this difference, in particular the possibility of language-specificity.
  • Cutler, A. (1992). Why not abolish psycholinguistics? In W. Dressler, H. Luschützky, O. Pfeiffer, & J. Rennison (Eds.), Phonologica 1988 (pp. 77-87). Cambridge: Cambridge University Press.
  • Cutler, A., Norris, D., & McQueen, J. M. (2000). Tracking TRACE’s troubles. In A. Cutler, J. M. McQueen, & R. Zondervan (Eds.), Proceedings of SWAP (Workshop on Spoken Word Access Processes) (pp. 63-66). Nijmegen: Max-Planck-Institute for Psycholinguistics.

    Abstract

    Simulations explored the inability of the TRACE model of spoken-word recognition to model the effects on human listening of acoustic-phonetic mismatches in word forms. The source of TRACE's failure lay not in its interactive connectivity, not in the presence of interword competition, and not in the use of phonemic representations, but in the need for continuously optimised interpretation of the input. When an analogue of TRACE was allowed to cycle to asymptote on every slice of input, an acceptable simulation of the subcategorical mismatch data was achieved. Even then, however, the simulation was not as close as that produced by the Merge model.
  • Cutler, A. (1995). Universal and Language-Specific in the Development of Speech. Biology International, (Special Issue 33).
  • Cychosz, M., Cristia, A., Bergelson, E., Casillas, M., Baudet, G., Warlaumont, A. S., Scaff, C., Yankowitz, L., & Seidl, A. (2021). Vocal development in a large‐scale crosslinguistic corpus. Developmental Science, 24(5): e13090. doi:10.1111/desc.13090.

    Abstract

    This study evaluates whether early vocalizations develop in similar ways in children across diverse cultural contexts. We analyze data from daylong audio recordings of 49 children (1–36 months) from five different language/cultural backgrounds. Citizen scientists annotated these recordings to determine if child vocalizations contained canonical transitions or not (e.g., “ba” vs. “ee”). Results revealed that the proportion of clips reported to contain canonical transitions increased with age. Furthermore, this proportion exceeded 0.15 by around 7 months, replicating and extending previous findings on canonical vocalization development but using data from the natural environments of a culturally and linguistically diverse sample. This work explores how crowdsourcing can be used to annotate corpora, helping establish developmental milestones relevant to multiple languages and cultures. Lower inter‐annotator reliability on the crowdsourcing platform, relative to more traditional in‐lab expert annotators, means that a larger number of unique annotators and/or annotations are required, and that crowdsourcing may not be a suitable method for more fine‐grained annotation decisions. Audio clips used for this project are compiled into a large‐scale infant vocalization corpus that is available for other researchers to use in future work.

    Additional information

    supporting information audio data
  • Dahan, D., & Gaskell, M. G. (2007). The temporal dynamics of ambiguity resolution: Evidence from spoken-word recognition. Journal of Memory and Language, 57(4), 483-501. doi:10.1016/j.jml.2007.01.001.

    Abstract

    Two experiments examined the dynamics of lexical activation in spoken-word recognition. In both, the key materials were pairs of onset-matched picturable nouns varying in frequency. Pictures associated with these words, plus two distractor pictures were displayed. A gating task, in which participants identified the picture associated with gradually lengthening fragments of spoken words, examined the availability of discriminating cues in the speech waveforms for these pairs. There was a clear frequency bias in participants’ responses to short, ambiguous fragments, followed by a temporal window in which discriminating information gradually became available. A visual-world experiment examined speech contingent eye movements. Fixation analyses suggested that frequency influences lexical competition well beyond the point in the speech signal at which the spoken word has been fully discriminated from its competitor (as identified using gating). Taken together, these data support models in which the processing dynamics of lexical activation are a limiting factor on recognition speed, over and above the temporal unfolding of the speech signal.
  • Dahan, D., & Tanenhaus, M. K. (2004). Continuous mapping from sound to meaning in spoken-language comprehension: Immediate effects of verb-based thematic constraints. Journal of Experimental Psychology: Learning, Memory, and Cognition, 30(2), 498-513. doi:10.1037/0278-7393.30.2.498.

    Abstract

    The authors used 2 “visual-world” eye-tracking experiments to examine lexical access using Dutch constructions in which the verb did or did not place semantic constraints on its subsequent subject noun phrase. In Experiment 1, fixations to the picture of a cohort competitor (overlapping with the onset of the referent’s name, the subject) did not differ from fixations to a distractor in the constraining-verb condition. In Experiment 2, cross-splicing introduced phonetic information that temporarily biased the input toward the cohort competitor. Fixations to the cohort competitor temporarily increased in both the neutral and constraining conditions. These results favor models in which mapping from the input onto meaning is continuous over models in which contextual effects follow access of an initial form-based competitor set.
  • Daller, M. H., Treffers-Daller, J., & Furman, R. (2011). Transfer of conceptualization patterns in bilinguals: The construal of motion events in Turkish and German. Bilingualism: Language and Cognition, 14(1), 95-119. doi:10.1017/S1366728910000106.

    Abstract

    In the present article we provide evidence for the occurrence of transfer of conceptualization patterns in narratives of two German-Turkish bilingual groups. All bilingual participants grew up in Germany, but only one group is still resident in Germany (n = 49). The other, the returnees, moved back to Turkey after having lived in Germany for thirteen years (n = 35). The study is based on the theoretical framework for conceptual transfer outlined in Jarvis and Pavlenko (2008) and on the typology of satellite-framed and verb-framed languages developed by Talmy (1985, 1991, 2000a, b) and Slobin (1987, 1996, 2003, 2004, 2005, 2006). In the present study we provide evidence for the hypothesis that language structure affects the organization of information structure at the level of the Conceptualizer, and show that bilingual speakers’ conceptualization of motion events is influenced by the dominant linguistic environment in both languages (German for the group in Germany and Turkish for the returnees). The returnees follow the Turkish blueprints for the conceptualization of motion, in both Turkish and German event construals, whereas the German-resident bilinguals follow the German blueprints, when speaking German as well as Turkish. We argue that most of the patterns found are the result of transfer of conceptualization patterns from the dominant language of the environment.
  • Dalli, A., Tablan, V., Bontcheva, K., Wilks, Y., Broeder, D., Brugman, H., & Wittenburg, P. (2004). Web services architecture for language resources. In M. Lino, M. Xavier, F. Ferreira, R. Costa, & R. Silva (Eds.), Proceedings of the 4th International Conference on Language Resources and Evaluation (LREC2004) (pp. 365-368). Paris: ELRA - European Language Resources Association.
  • Daly, T., Chen, X. S., & Penny, D. (2011). How old are RNA networks? In L. J. Collins (Ed.), RNA infrastructure and networks (pp. 255-273). New York: Springer Science + Business Media and Landes Bioscience.

    Abstract

    Some major classes of RNAs (such as mRNA, rRNA, tRNA and RNase P) are ubiquitous in all living systems so are inferred to have arisen early during the origin of life. However, the situation is not so clear for the system of RNA regulatory networks that continue to be uncovered, especially in eukaryotes. It is increasingly being recognised that networks of small RNAs are important for regulation in all cells, but it is not certain whether the origin of these networks are as old as rRNAs and tRNA. Another group of ncRNAs, including snoRNAs, occurs mainly in archaea and eukaryotes and their ultimate origin is less certain, although perhaps the simplest hypothesis is that they were present in earlier stages of life and were lost from bacteria. Some RNA networks may trace back to an early stage when there was just RNA and proteins, the RNP‑world; before DNA.
  • Danielsen, S., Dunn, M., & Muysken, P. (2011). The spread of the Arawakan languages: A view from structural phylogenetics. In A. Hornborg, & J. D. Hill (Eds.), Ethnicity in ancient Amazonia: Reconstructing past identities from archaeology, linguistics, and ethnohistory (pp. 173-196). Boulder: University Press of Colorado.
  • Danziger, E. (1995). Intransitive predicate form class survey. In D. Wilkins (Ed.), Extensions of space and beyond: manual for field elicitation for the 1995 field season (pp. 46-53). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.3004298.

    Abstract

    Different linguistic structures allow us to highlight distinct aspects of a situation. The aim of this survey is to investigate similarities and differences in the expression of situations or events as “stative” (maintaining a state), “inchoative” (adopting a state) and “agentive” (causing something to be in a state). The questionnaire focuses on the encoding of stative, inchoative and agentive possibilities for the translation equivalents of a set of English verbs.
  • Danziger, E. (1995). Posture verb survey. In D. Wilkins (Ed.), Extensions of space and beyond: manual for field elicitation for the 1995 field season (pp. 33-34). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.3004235.

    Abstract

    Expressions of human activities and states are a rich area for cross-linguistic comparison. Some languages of the world treat human posture verbs (e.g., sit, lie, kneel) as a special class of predicates, with distinct formal properties. This survey examines lexical, semantic and grammatical patterns for posture verbs, with special reference to contrasts between “stative” (maintaining a posture), “inchoative” (adopting a posture), and “agentive” (causing something to adopt a posture) constructions. The enquiry is thematically linked to the more general questionnaire 'Intransitive Predicate Form Class Survey'.
  • Davids, N., Segers, E., Van den Brink, D., Mitterer, H., van Balkom, H., Hagoort, P., & Verhoeven, L. (2011). The nature of auditory discrimination problems in children with specific language impairment: An MMN study. Neuropsychologia, 49, 19-28. doi:10.1016/j.neuropsychologia.2010.11.001.

    Abstract

    Many children with Specific Language Impairment (SLI) show impairments in discriminating auditorily presented stimuli. The present study investigates whether these discrimination problems are speech specific or of a general auditory nature. This was studied by using a linguistic and nonlinguistic contrast that were matched for acoustic complexity in an active behavioral task and a passive ERP paradigm, known to elicit the mismatch negativity (MMN). In addition, attention skills and a variety of language skills were measured. Participants were 25 five-year-old Dutch children with SLI having receptive as well as productive language problems and 25 control children with typical speechand language development. At the behavioral level, the SLI group was impaired in discriminating the linguistic contrast as compared to the control group, while both groups were unable to distinguish the non-linguistic contrast. Moreover, the SLI group tended to have impaired attention skills which correlated with performance on most of the language tests. At the neural level, the SLI group, in contrast to the control group, did not show an MMN in response to either the linguistic or nonlinguistic contrast. The MMN data are consistent with an account that relates the symptoms in children with SLI to non-speech processing difficulties.
  • Davidson, D., & Indefrey, P. (2011). Error-related activity and correlates of grammatical plasticity. Frontiers in Psychology, 2: 219. doi:10.3389/fpsyg.2011.00219.

    Abstract

    Cognitive control involves not only the ability to manage competing task demands, but also the ability to adapt task performance during learning. This study investigated how violation-, response-, and feedback-related electrophysiological (EEG) activity changes over time during language learning. Twenty-two Dutch learners of German classified short prepositional phrases presented serially as text. The phrases were initially presented without feedback during a pre-test phase, and then with feedback in a training phase on two separate days spaced 1 week apart. The stimuli included grammatically correct phrases, as well as grammatical violations of gender and declension. Without feedback, participants' classification was near chance and did not improve over trials. During training with feedback, behavioral classification improved and violation responses appeared to both types of violation in the form of a P600. Feedback-related negative and positive components were also present from the first day of training. The results show changes in the electrophysiological responses in concert with improving behavioral discrimination, suggesting that the activity is related to grammar learning.
  • Davidson, D. J., & Indefrey, P. (2007). An inverse relation between event-related and time–frequency violation responses in sentence processing. Brain Research, 1158, 81-92. doi:10.1016/j.brainres.2007.04.082.

    Abstract

    The relationship between semantic and grammatical processing in sentence comprehension was investigated by examining event-related potential (ERP) and event-related power changes in response to semantic and grammatical violations. Sentences with semantic, phrase structure, or number violations and matched controls were presented serially (1.25 words/s) to 20 participants while EEG was recorded. Semantic violations were associated with an N400 effect and a theta band increase in power, while grammatical violations were associated with a P600 effect and an alpha/beta band decrease in power. A quartile analysis showed that for both types of violations, larger average violation effects were associated with lower relative amplitudes of oscillatory activity, implying an inverse relation between ERP amplitude and event-related power magnitude change in sentence processing.
  • Decuyper, C., Brysbaert, M., Brodeur, M. B., & Meyer, A. S. (2021). Bank of Standardized Stimuli (BOSS): Dutch names for 1400 photographs. Journal of Cognition, 4(1): 33. doi:10.5334/joc.180.

    Abstract

    We present written naming norms from 153 young adult Dutch speakers for 1397 photographs (the BOSS set; see Brodeur, Dionne-Dostie, Montreuil, & Lepage, 2010; Brodeur, Guérard, & Bouras, 2014). From the norming study, we report the preferred (modal) name, alternative names, name agreement, and average object agreement. In addition, the data base includes Zipf frequency, word prevalence and Age of Acquisition for the modal picture names collected. Furthermore, we describe a subset of 359 photographs with very good name agreement and a subset of 35 photos with two common names. These sets may be particularly valuable for designing experiments. Though the participants typed the object names, comparisons with other datasets indicate that the collected norms are valuable for spoken naming studies as well.
  • Dediu, D. (2016). A multi-layered problem. IEEE CDS Newsletter, 13, 14-15.

    Abstract

    A response to Moving Beyond Nature-Nurture: a Problem of Science or Communication? by John Spencer, Mark Blumberg and David Shenk
  • Dediu, D., & Moisik, S. (2016). Defining and counting phonological classes in cross-linguistic segment databases. In N. Calzolari, K. Choukri, T. Declerck, S. Goggi, M. Grobelnik, B. Maegaard, J. Mariani, H. Mazo, A. Moreno, J. Odijk, & S. Piperidis (Eds.), Proceedings of LREC 2016: 10th International Conference on Language Resources and Evaluation (pp. 1955-1962). Paris: European Language Resources Association (ELRA).

    Abstract

    Recently, there has been an explosion in the availability of large, good-quality cross-linguistic databases such as WALS (Dryer & Haspelmath, 2013), Glottolog (Hammarstrom et al., 2015) and Phoible (Moran & McCloy, 2014). Databases such as Phoible contain the actual segments used by various languages as they are given in the primary language descriptions. However, this segment-level representation cannot be used directly for analyses that require generalizations over classes of segments that share theoretically interesting features. Here we present a method and the associated R (R Core Team, 2014) code that allows the exible denition of such meaningful classes and that can identify the sets of segments falling into such a class for any language inventory. The method and its results are important for those interested in exploring cross-linguistic patterns of phonetic and phonological diversity and their relationship to extra-linguistic factors and processes such as climate, economics, history or human genetics.
  • Dediu, D., & Moisik, S. R. (2016). Anatomical biasing of click learning and production: An MRI and 3d palate imaging study. In S. G. Roberts, C. Cuskley, L. McCrohon, L. Barceló-Coblijn, O. Feher, & T. Verhoef (Eds.), The Evolution of Language: Proceedings of the 11th International Conference (EVOLANG11). Retrieved from http://evolang.org/neworleans/papers/57.html.

    Abstract

    The current paper presents results for data on click learning obtained from a larger imaging study (using MRI and 3D intraoral scanning) designed to quantify and characterize intra- and inter-population variation of vocal tract structures and the relation of this to speech production. The aim of the click study was to ascertain whether and to what extent vocal tract morphology influences (1) the ability to learn to produce clicks and (2) the productions of those that successfully learn to produce these sounds. The results indicate that the presence of an alveolar ridge certainly does not prevent an individual from learning to produce click sounds (1). However, the subtle details of how clicks are produced may indeed be driven by palate shape (2).
  • Dediu, D. (2011). Are languages really independent from genes? If not, what would a genetic bias affecting language diversity look like? Human Biology, 83, 279-296. doi:10.3378/027.083.0208.

    Abstract

    It is generally accepted that the relationship between human genes
    and language is very complex and multifaceted. This has its roots in the
    “regular” complexity governing the interplay among genes and between genes
    and environment for most phenotypes, but with the added layer of supraontogenetic
    and supra-individual processes defining culture. At the coarsest
    level, focusing on the species, it is clear that human-specific—but not necessarily
    faculty-specific—genetic factors subtend our capacity for language and a
    currently very productive research program is aiming at uncovering them. At the
    other end of the spectrum, it is uncontroversial that individual-level variations in
    different aspects related to speech and language have an important genetic
    component and their discovery and detailed characterization have already started
    to revolutionize the way we think about human nature. However, at the
    intermediate, glossogenetic/population level, the relationship becomes controversial,
    partly due to deeply ingrained beliefs about language acquisition and
    universality and partly because of confusions with a different type of genelanguages
    correlation due to shared history. Nevertheless, conceptual, mathematical
    and computational models—and, recently, experimental evidence from
    artificial languages and songbirds—have repeatedly shown that genetic biases
    affecting the acquisition or processing of aspects of language and speech can be
    amplified by population-level intergenerational cultural processes and made
    manifest either as fixed “universal” properties of language or as structured
    linguistic diversity. Here, I review several such models as well as the recently
    proposed case of a causal relationship between the distribution of tone languages
    and two genes related to brain growth and development, ASPM and Microcephalin,
    and I discuss the relevance of such genetic biasing for language
    evolution, change, and diversity.
  • Dediu, D. (2011). A Bayesian phylogenetic approach to estimating the stability of linguistic features and the genetic biasing of tone. Proceedings of the Royal Society of London/B, 278(1704), 474-479. doi:10.1098/rspb.2010.1595.

    Abstract

    Language is a hallmark of our species and understanding linguistic diversity is an area of major interest. Genetic factors influencing the cultural transmission of language provide a powerful and elegant explanation for aspects of the present day linguistic diversity and a window into the emergence and evolution of language. In particular, it has recently been proposed that linguistic tone—the usage of voice pitch to convey lexical and grammatical meaning—is biased by two genes involved in brain growth and development, ASPM and Microcephalin. This hypothesis predicts that tone is a stable characteristic of language because of its ‘genetic anchoring’. The present paper tests this prediction using a Bayesian phylogenetic framework applied to a large set of linguistic features and language families, using multiple software implementations, data codings, stability estimations, linguistic classifications and outgroup choices. The results of these different methods and datasets show a large agreement, suggesting that this approach produces reliable estimates of the stability of linguistic data. Moreover, linguistic tone is found to be stable across methods and datasets, providing suggestive support for the hypothesis of genetic influences on its distribution.
  • Dediu, D., & de Boer, B. (2016). Language evolution needs its own journal. Journal of Language Evolution, 1, 1-6. doi:10.1093/jole/lzv001.

    Abstract

    Interest in the origins and evolution of language has been around for as long as language has been around. However, only recently has the empirical study of language come of age. We argue that the field has sufficiently advanced that it now needs its own journal—the Journal of Language Evolution.
  • Dediu, D., & Christiansen, M. H. (2016). Language evolution: Constraints and opportunities from modern genetics. Topics in Cognitive Science, 8, 361-370. doi:10.1111/tops.12195.

    Abstract

    Our understanding of language, its origins and subsequent evolution (including language change) is shaped not only by data and theories from the language sciences, but also fundamentally by the biological sciences. Recent developments in genetics and evolutionary theory offer both very strong constraints on what scenarios of language evolution are possible and probable but also offer exciting opportunities for understanding otherwise puzzling phenomena. Due to the intrinsic breathtaking rate of advancement in these fields, the complexity, subtlety and sometimes apparent non-intuitiveness of the phenomena discovered, some of these recent developments have either being completely missed by language scientists, or misperceived and misrepresented. In this short paper, we offer an update on some of these findings and theoretical developments through a selection of illustrative examples and discussions that cast new light on current debates in the language sciences. The main message of our paper is that life is much more complex and nuanced than anybody could have predicted even a few decades ago, and that we need to be flexible in our theorizing instead of embracing a priori dogmas and trying to patch paradigms that are no longer satisfactory.
  • Dediu, D., & Ladd, D. R. (2007). Linguistic tone is related to the population frequency of the adaptive haplogroups of two brain size genes, ASPM and Microcephalin. PNAS, 104, 10944-10949. doi:10.1073/pnas.0610848104.

    Abstract

    The correlations between interpopulation genetic and linguistic diversities are mostly noncausal (spurious), being due to historical processes and geographical factors that shape them in similar ways. Studies of such correlations usually consider allele frequencies and linguistic groupings (dialects, languages, linguistic families or phyla), sometimes controlling for geographic, topographic, or ecological factors. Here, we consider the relation between allele frequencies and linguistic typological features. Specifically, we focus on the derived haplogroups of the brain growth and development-related genes ASPM and Microcephalin, which show signs of natural selection and a marked geographic structure, and on linguistic tone, the use of voice pitch to convey lexical or grammatical distinctions. We hypothesize that there is a relationship between the population frequency of these two alleles and the presence of linguistic tone and test this hypothesis relative to a large database (983 alleles and 26 linguistic features in 49 populations), showing that it is not due to the usual explanatory factors represented by geography and history. The relationship between genetic and linguistic diversity in this case may be causal: certain alleles can bias language acquisition or processing and thereby influence the trajectory of language change through iterated cultural transmission.

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  • Dediu, D. (2007). Non-spurious correlations between genetic and linguistic diversities in the context of human evolution. PhD Thesis, University of Edinburgh, Edinburgh, UK.
  • Dediu, D. (2016). Typology for the masses. Linguistic typology, 20(3), 579-581. doi:10.1515/lingty-2016-0029.
  • Defina, R. (2016). Do serial verb constructions describe single events? A study of co-speech gestures in Avatime. Language, 92(4), 890-910. doi:10.1353/lan.2016.0076.

    Abstract

    Serial verb constructions have often been said to refer to single conceptual events. However, evidence to support this claim has been elusive. This article introduces co-speech gestures as a new way of investigating the relationship. The alignment patterns of gestures with serial verb constructions and other complex clauses were compared in Avatime (Ka-Togo, Kwa, Niger-Congo). Serial verb constructions tended to occur with single gestures overlapping the entire construction. In contrast, other complex clauses were more likely to be accompanied by distinct gestures overlapping individual verbs. This pattern of alignment suggests that serial verb constructions are in fact used to describe single events.

    Additional information

    https://doi.org/10.1353/lan.2016.0069
  • Defina, R. (2016). Events in language and thought: The case of serial verb constructions in Avatime. PhD Thesis, Radboud University Nijmegen, Nijmegen.
  • Defina, R. (2016). Serial verb constructions and their subtypes in Avatime. Studies in Language, 40(3), 648-680. doi:10.1075/sl.40.3.07def.
  • Dell, G. S., Reed, K. D., Adams, D. R., & Meyer, A. S. (2000). Speech errors, phonotactic constraints, and implicit learning: A study of the role of experience in language production. Journal of Experimental Psychology: Learning, Memory, and Cognition, 26, 1355-1367. doi:10.1037/0278-7393.26.6.1355.

    Abstract

    Speech errors follow the phonotactics of the language being spoken. For example, in English, if [n] is mispronounced as [n] the [n] will always appear in a syllable coda. The authors created an analogue to this phenomenon by having participants recite lists of consonant-vowel-consonant syllables in 4 sessions on different days. In the first 2 experiments, some consonants were always onsets, some were always codas, and some could be both. In a third experiment, the set of possible onsets and codas depended on vowel identity. In all 3 studies, the production errors that occurred respected the "phonotactics" of the experiment. The results illustrate the implicit learning of the sequential constraints present in the stimuli and show that the language production system adapts to recent experience.
  • DeMayo, B., Kellier, D., Braginsky, M., Bergmann, C., Hendriks, C., Rowland, C. F., Frank, M., & Marchman, V. (2021). Web-CDI: A system for online administration of the MacArthur-Bates Communicative Development Inventories. Language Development Research, 10.34758/kr8e-w591. doi:10.34758/kr8e-w591.

    Abstract

    Understanding the mechanisms that drive variation in children’s language acquisition requires large, population-representative datasets of children’s word learning across development. Parent report measures such as the MacArthur-Bates Communicative Development Inventories (CDI) are commonly used to collect such data, but the traditional paper-based forms make the curation of large datasets logistically challenging. Many CDI datasets are thus gathered using convenience samples, often recruited from communities in proximity to major research institutions. Here, we introduce Web-CDI, a web-based tool which allows researchers to collect CDI data online. Web-CDI contains functionality to collect and manage longitudinal data, share links to test administrations, and download vocabulary scores. To date, over 3,500 valid Web-CDI administrations have been completed. General trends found in past norming studies of the CDI are present in data collected from Web-CDI: scores of children’s productive vocabulary grow with age, female children show a slightly faster rate of vocabulary growth, and participants with higher levels of educational attainment report slightly higher vocabulary production scores than those with lower levels of education attainment. We also report results from an effort to oversample non-white, lower-education participants via online recruitment (N = 241). These data showed similar demographic trends to the full sample but this effort resulted in a high exclusion rate. We conclude by discussing implications and challenges for the collection of large, population-representative datasets.

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    data and code
  • Den Hoed, J., Devaraju, K., & Fisher, S. E. (2021). Molecular networks of the FOXP2 transcription factor in the brain. EMBO Reports, 22(8): e52803. doi:10.15252/embr.202152803.

    Abstract

    The discovery of the FOXP2 transcription factor, and its implication in a rare severe human speech and language disorder, has led to two decades of empirical studies focused on uncovering its roles in the brain using a range of in vitro and in vivo methods. Here, we discuss what we have learned about the regulation of FOXP2, its downstream effectors, and its modes of action as a transcription factor in brain development and function, providing an integrated overview of what is currently known about the critical molecular networks.
  • Den Hoed, J., De Boer, E., Voisin, N., Dingemans, A. J. M., Guex, N., Wiel, L., Nellaker, C., Amudhavalli, S. M., Banka, S., Bena, F. S., Ben-Zeev, B., Bonagura, V. R., Bruel, A.-L., Brunet, T., Brunner, H. G., Chew, H. B., Chrast, J., Cimbalistienė, L., Coon, H., The DDD study, Délot, E. C. and 77 moreDen Hoed, J., De Boer, E., Voisin, N., Dingemans, A. J. M., Guex, N., Wiel, L., Nellaker, C., Amudhavalli, S. M., Banka, S., Bena, F. S., Ben-Zeev, B., Bonagura, V. R., Bruel, A.-L., Brunet, T., Brunner, H. G., Chew, H. B., Chrast, J., Cimbalistienė, L., Coon, H., The DDD study, Délot, E. C., Démurger, F., Denommé-Pichon, A.-S., Depienne, C., Donnai, D., Dyment, D. A., Elpeleg, O., Faivre, L., Gilissen, C., Granger, L., Haber, B., Hachiya, Y., Hamzavi Abedi, Y., Hanebeck, J., Hehir-Kwa, J. Y., Horist, B., Itai, T., Jackson, A., Jewell, R., Jones, K. L., Joss, S., Kashii, H., Kato, M., Kattentidt-Mouravieva, A. A., Kok, F., Kotzaeridou, U., Krishnamurthy, V., Kučinskas, V., Kuechler, A., Lavillaureix, A., Liu, P., Manwaring, L., Matsumoto, N., Mazel, B., McWalter, K., Meiner, V., Mikati, M. A., Miyatake, S., Mizuguchi, T., Moey, L. H., Mohammed, S., Mor-Shaked, H., Mountford, H., Newbury-Ecob, R., Odent, S., Orec, L., Osmond, M., Palculict, T. B., Parker, M., Petersen, A., Pfundt, R., Preikšaitienė, E., Radtke, K., Ranza, E., Rosenfeld, J. A., Santiago-Sim, T., Schwager, C., Sinnema, M., Snijders Blok, L., Spillmann, R. C., Stegmann, A. P. A., Thiffault, I., Tran, L., Vaknin-Dembinsky, A., Vedovato-dos-Santos, J. H., Vergano, S. A., Vilain, E., Vitobello, A., Wagner, M., Waheeb, A., Willing, M., Zuccarelli, B., Kini, U., Newbury, D. F., Kleefstra, T., Reymond, A., Fisher, S. E., & Vissers, L. E. L. M. (2021). Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction. The American Journal of Human Genetics, 108(2), 346-356. doi:10.1016/j.ajhg.2021.01.007.

    Abstract

    Whereas large-scale statistical analyses can robustly identify disease-gene relationships, they do not accurately capture genotype-phenotype correlations or disease mechanisms. We use multiple lines of independent evidence to show that different variant types in a single gene, SATB1, cause clinically overlapping but distinct neurodevelopmental disorders. Clinical evaluation of 42 individuals carrying SATB1 variants identified overt genotype-phenotype relationships, associated with different pathophysiological mechanisms, established by functional assays. Missense variants in the CUT1 and CUT2 DNA-binding domains result in stronger chromatin binding, increased transcriptional repression and a severe phenotype. Contrastingly, variants predicted to result in haploinsufficiency are associated with a milder clinical presentation. A similarly mild phenotype is observed for individuals with premature protein truncating variants that escape nonsense-mediated decay and encode truncated proteins, which are transcriptionally active but mislocalized in the cell. Our results suggest that in-depth mutation-specific genotype-phenotype studies are essential to capture full disease complexity and to explain phenotypic variability.
  • Den Os, E., & Boves, L. (2004). Natural multimodal interaction for design applications. In P. Cunningham (Ed.), Adoption and the knowledge economy (pp. 1403-1410). Amsterdam: IOS Press.
  • Deriziotis, P., André, R., Smith, D. M., Goold, R., Kinghorn, K. J., Kristiansen, M., Nathan, J. A., Rosenzweig, R., Krutauz, D., Glickman, M. H., Collinge, J., Goldberg, A. L., & Tabrizi, S. J. (2011). Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry. EMBO Journal, 30(15), 3065-3077. doi:10.1038/emboj.2011.224.

    Abstract

    * Deriziotis, P., André, R., and Smith. D.M. contributed equally to this work * - Prion diseases are associated with the conversion of cellular prion protein (PrP(C)) to toxic β-sheet isoforms (PrP(Sc)), which are reported to inhibit the ubiquitin-proteasome system (UPS). Accordingly, UPS substrates accumulate in prion-infected mouse brains, suggesting impairment of the 26S proteasome. A direct interaction between its 20S core particle and PrP isoforms was demonstrated by immunoprecipitation. β-PrP aggregates associated with the 20S particle, but did not impede binding of the PA26 complex, suggesting that the aggregates do not bind to its ends. Aggregated β-PrP reduced the 20S proteasome's basal peptidase activity, and the enhanced activity induced by C-terminal peptides from the 19S ATPases or by the 19S regulator itself, including when stimulated by polyubiquitin conjugates. However, the 20S proteasome was not inhibited when the gate in the α-ring was open due to a truncation mutation or by association with PA26/PA28. These PrP aggregates inhibit by stabilising the closed conformation of the substrate entry channel. A similar inhibition of substrate entry into the proteasome may occur in other neurodegenerative diseases where misfolded β-sheet-rich proteins accumulate.

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