Publications

Abstract

Schizophrenia is a complex disorder that affects cognitive function and has been linked, both in patients and animal models, to dysfunction of the GABAergic system. However, the pathophysiological consequences of this dysfunction are not well understood. Here, we examined the GABAergic system in an animal model displaying schizophrenia-relevant features, the apomorphine-susceptible (APO-SUS) rat and its phenotypic counterpart, the apomorphine-unsusceptible (APO-UNSUS) rat at postnatal day 20-22. We found changes in the expression of the GABA-synthesizing enzyme GAD67 specifically in the prelimbic-but not the infralimbic region of the medial prefrontal cortex (mPFC), indicative of reduced inhibitory function in this region in APO-SUS rats. While we did not observe changes in basal synaptic transmission onto LII/III pyramidal cells in the mPFC of APO-SUS compared to APO-UNSUS rats, we report reduced paired-pulse ratios at longer inter-stimulus intervals. The GABA(B) receptor antagonist CGP 55845 abolished this reduction, indicating that the decreased paired-pulse ratio was caused by increased GABA(B) signaling. Consistently, we find an increased expression of the GABA(B1) receptor subunit in APO-SUS rats. Our data provide physiological evidence for increased presynaptic GABAB signaling in the mPFC of APO-SUS rats, further supporting an important role for the GABAergic system in the pathophysiology of schizophrenia.

Abstract

This article discusses how the Trobriand Islanders speak about body and mind. It addresses the following questions: do the linguistic datafit into theories about lexical universals of body-part terminology? Can we make inferences about the Trobrianders' conceptualization of psychological and physical states on the basis of these data? If a Trobriand Islander sees these idioms as external manifestations of inner states, then can we interpret them as a kind of ethnopsychological theory about the body and its role for emotions, knowledge, thought, memory, and so on? Can these idioms be understood as representation of Trobriand ethnopsychological theory?

Abstract

This paper describes how the Trobriand Islanders of Papua New Guinea used to construct their big seagoing masawa canoes and how they used to make their sails, what forms of different knowledge and expertise they needed to do this during various stages of the construction processes, how this knowledge was socially distributed, and the social implications of all the joint communal activities that were necessary until a new canoe could be launched. Then it tries to answer the question why the complex distributed knowledge of how to make a masawa has been gradually getting lost in most of the village communities on the Trobriand Islands; and finally it outlines and discusses the implications of this loss for the Trobriand Islanders' culture, for their social construction of reality, and for their indigenous cognitive capacities.

Abstract

(TMCD 9602). Taipei: Trees Music & Art, 12-1, Lane 10, Sec. 2, Hsin Yi Rd. Taipei, TAIWAN. Distributed by Sony Music Entertainment (Taiwan)Ltd.,6th fl. No 35 , Lane 11, Kwang-Fu N. Rd., Taipei TAIWAN (CD accompanied by a full color bucklet)

Abstract

Members of the MPI for Psycholinguistics are researching the interrelationship between language, cognition and the conceptualization of space in various languages. Research results show that there are three frames of spatial reference, the absolute, the relative, and the intrinsic frame of reference. This study first presents results of this research in general and then discusses the results for Kilivila. Speakers of this Austronesian language prefer the intrinsic frame of reference for the location of objects with respect to each other in a given spatial configuration. But they prefer an absolute frame of reference system in referring to the spatial orientation of objects in a given
spatial configuration. Moreover, the hypothesis is confirmed that languages seem to influence the choice and the kind of conceptual parameters their speakers use to solve non-verbal problems within the domain of space.

Abstract

This entry takes an interdisciplinary approach to linguistic pragmatics. It discusses how the meaning of utterances can only be understood in relation to overall cultural, social, and interpersonal contexts, as well as to culture-specific conventions and the speech events in which they are embedded. The entry discusses core issues of pragmatics such as speech act theory, conversational implicature, deixis, gesture, interaction strategies, ritual communication, phatic communion, linguistic relativity, ethnography of speaking, ethnomethodology, and conversation analysis. It takes a transdisciplinary view of the field, showing that linguistic pragmatics has its predecessors in other disciplines such as philosophy, psychology, ethology, ethnology, and sociology.

Abstract

Translation of the first four chapters of Western linguistics: An historical introduction (1998)

Abstract

The present study paints the intellectual environment in which Ferdinand de Saussure developed his ideas about language and linguistics during the fin de siècle. It sketches his dissatisfaction with that environment to the extent that it touched on linguistics, and shows the new course he was trying to steer on the basis of ideas that seemed to open new and exciting perspectives, even though they were still vaguely defined. As Saussure himself was extremely reticent about his sources and intellectual pedigree, his stance in the lively European cultural context in which he lived can only be established through textual critique and conjecture. On this basis, it is concluded that Saussure, though relatively uninformed about its historical roots, essentially aimed at integrating the rationalist tradition current in the sciences in his day into a new, ‘scientific’ general theory of language. In this, he was heavily indebted to a few predecessors, such as the French philosopher-psychologist Victor Egger, and particularly to the French psychologist, historian and philosopher Hippolyte Taine, who was a major cultural influence in nineteenth-century France, though now largely forgotten. The present study thus supports Hans Aarsleff's analysis, where, for the first time, Taine's influence is emphasised, and rejects John Joseph's contention that Taine had no influence and that, instead, Saussure was influenced mainly by the romanticist Adolphe Pictet. Saussure abhorred Pictet's method of etymologising, which predated the Young Grammarian school, central to Saussure's linguistic education. The issue has implications for the positioning of Saussure in the history of linguistics. Is he part of the non-analytical, romanticist and experience-based European strand of thought that is found in art and postmodernist philosophy and is sometimes called structuralism, or is he a representative of the short-lived European branch of specifically linguistic structuralism, which was rationalist in outlook, more science-oriented and more formalist, but lost out to American structuralism? The latter seems to be the case, though phenomenology, postmodernism and art have lately claimed Saussure as an icon

Abstract

The prime purpose of this paper is, first, to restore to discourse-bound occasion sentences their rightful central place in semantics and secondly, taking these as the basic propositional elements in the logical analysis of language, to contribute to the development of an adequate logic of occasion sentences and a mathematical (Boolean) foundation for such a logic, thus preparing the ground for more adequate semantic, logical and mathematical foundations of the study of natural language. Some of the insights elaborated in this paper have appeared in the literature over the past thirty years, and a number of new developments have resulted from them. The present paper aims atproviding an integrated conceptual basis for this new development in semantics. In Section 1 it is argued that the reduction by translation of occasion sentences to eternal sentences, as proposed by Russell and Quine, is semantically and thus logically inadequate. Natural language is a system of occasion sentences, eternal sentences being merely boundary cases. The logic hasfewer tasks than is standardly assumed, as it excludes semantic calculi, which depend crucially on information supplied by cognition and context and thus belong to cognitive psychology rather than to logic. For sentences to express a proposition and thus be interpretable and informative, they must first be properly anchored in context. A proposition has a truth value when it is, moreover, properly keyed in the world, i.e. is about a situation in the world. Section 2 deals with the logical properties of natural language. It argues that presuppositional phenomena require trivalence and presents the trivalent logic PPC3, with two kinds of falsity and two negations. It introduces the notion of Σ-space for a sentence A (or A/A, the set of situations in which A is true) as the basis of logical model theory, and the notion of PA/ (the Σ-space of the presuppositions of A), functioning as a `private' subuniverse for A/A. The trivalent Kleene calculus is reinterpreted as a logical account of vagueness, rather than of presupposition. PPC3 and the Kleene calculus are refinements of standard bivalent logic and can be combined into one logical system. In Section 3 the adequacy of PPC3 as a truth-functional model of presupposition is considered more closely and given a Boolean foundation. In a noncompositional extended Boolean algebra, three operators are defined: 1a for the conjoined presuppositions of a, ã for the complement of a within 1a, and â for the complement of 1a within Boolean 1. The logical properties of this extended Boolean algebra are axiomatically defined and proved for all possible models. Proofs are provided of the consistency and the completeness of the system. Section 4 is a provisional exploration of the possibility of using the results obtained for a new discourse-dependent account of the logic of modalities in natural language. The overall result is a modified and refined logical and model-theoretic machinery, which takes into account both the discourse-dependency of natural language sentences and the necessity of selecting a key in the world before a truth value can be assigned

Abstract

The present study reports naming latencies and norms for 327 photos of objects in Dutch. We provide norms for eight psycholinguistic variables: age of acquisition, familiarity, imageability, image agreement, objective and subjective visual complexity, word frequency, word length in syllables and in letters, and name agreement. Furthermore, multiple regression analyses reveal that significant predictors of photo naming latencies are name agreement, word frequency, imageability, and image agreement. Naming latencies, norms and stimuli are provided as Supplemental Materials.

Abstract

The colour-word Stroop task and the picture-word interference task (PWI) have been used extensively to study the functional processes underlying spoken word production. One of the consistent behavioural effects in both tasks is the Stroop-like effect: The reaction time (RT) is longer on incongruent trials than on congruent trials. The effect in the Stroop task is usually linked to word planning, whereas the effect in the PWI task is associated with either word planning or perceptual encoding. To adjudicate between the word planning and perceptual encoding accounts of the effect in PWI, we conducted an EEG experiment consisting of three tasks: a standard colour-word Stroop task (three colours), a standard PWI task (39 pictures), and a Stroop-like version of the PWI task (three pictures). Participants overtly named the colours and pictures while their EEG was recorded. A Stroop-like effect in RTs was observed in all three tasks. ERPs at centro-parietal sensors started to deflect negatively for incongruent relative to congruent stimuli around 350 ms after stimulus onset for the Stroop, Stroop-like PWI, and the Standard PWI tasks: an N400 effect. No early differences were found in the PWI tasks. The onset of the Stroop-like effect at about 350 ms in all three tasks links the effect to word planning rather than perceptual encoding, which has been estimated in the literature to be finished around 200–250 ms after stimulus onset. We conclude that the Stroop-like effect arises during word planning in both Stroop and PWI.

Abstract

Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is prevalent in India, where about half of the world's estimated 800,000 cases occur. A role for the genetics of the host in variable susceptibility to leprosy has been indicated by familial clustering, twin studies, complex segregation analyses and human leukocyte antigen (HLA) association studies. We report here a genetic linkage scan of the genomes of 224 families from South India, containing 245 independent affected sibpairs with leprosy, mainly of the paucibacillary type. In a two-stage genome screen using 396 microsatellite markers, we found significant linkage (maximum lod score (MLS) = 4.09, P < 2x10-5) on chromosome 10p13 for a series of neighboring microsatellite markers, providing evidence for a major locus for this prevalent infectious disease. Thus, despite the polygenic nature of infectious disease susceptibility, some major, non-HLA-linked loci exist that may be mapped through obtainable numbers of affected sibling pairs.

Abstract

Previous studies have provided evidence that updating, inhibiting, and shifting abilities underlying executive control determine response time (RT) in language production. However, little is known about their electrophysiological basis and dynamics. In the present electroencephalography study, we assessed noun-phrase production using picture description and a picture-word interference paradigm. We measured picture description RTs to assess length, distractor, and switch effects, which have been related to the updating, inhibiting, and shifting abilities. In addition, we measured event-related brain potentials (ERPs). Previous research has suggested that inhibiting and shifting are associated with anterior and posterior N200 subcomponents, respectively, and updating with the P300. We obtained length, distractor, and switch effects in the RTs, and an interaction between length and switch. There was a widely distributed switch effect in the N200, an interaction of length and midline site in the N200, and a length effect in the P300, whereas distractor did not yield any ERP modulation. Moreover, length and switch interacted in the posterior N200. We argue that these results provide electrophysiological evidence that inhibiting and shifting of task set occur before updating in phrase planning.

Abstract

The present study examined how the updating, inhibiting, and shifting abilities underlying executive control influence spoken noun-phrase production. Previous studies provided evidence that updating and inhibiting, but not shifting, influence picture-naming response time (RT). However, little is known about the role of executive control in more complex forms of language production like generating phrases. We assessed noun-phrase production using picture description and a picture–word interference procedure. We measured picture description RT to assess length, distractor, and switch effects, which were assumed to reflect, respectively, the updating, inhibiting, and shifting abilities of adult participants. Moreover, for each participant we obtained scores on executive control tasks that measured verbal and nonverbal updating, nonverbal inhibiting, and nonverbal shifting. We found that both verbal and nonverbal updating scores correlated with the overall mean picture description RTs. Furthermore, the length effect in the RTs correlated with verbal but not nonverbal updating scores, while the distractor effect correlated with inhibiting scores. We did not find a correlation between the switch effect in the mean RTs and the shifting scores. However, the shifting scores correlated with the switch effect in the normal part of the underlying RT distribution. These results suggest that updating, inhibiting, and shifting each influence the speed of phrase production, thereby demonstrating a contribution of all three executive control abilities to language production.

Abstract

During oral reading, the eyes tend to be ahead of the voice (eye-voice span, EVS). It has been hypothesized that the extent to which this happens depends on the automaticity of reading processes, namely on the speed of print-to-sound conversion. We tested whether EVS is affected by another automaticity component – immunity from interference. To that end, we manipulated word familiarity (high-frequency, lowfrequency, and pseudowords, PW) and word length as proxies of immunity from interference, and we used linear mixed effects models to measure the effects of both variables on the time interval at which readers do parallel processing by gazing at word N C 1 while not having articulated word N yet (offset EVS). Parallel processing was enhanced by automaticity, as shown by familiarity length interactions on offset EVS, and it was impeded by lack of automaticity, as shown by the transformation of offset EVS into voice-eye span (voice ahead of the offset of the eyes) in PWs. The relation between parallel processing and automaticity was strengthened by the fact that offset EVS predicted reading velocity. Our findings contribute to understand how the offset EVS, an index that is obtained in oral reading, may tap into different components of automaticity that underlie reading ability, oral or silent. In addition, we compared the duration of the offset EVS with the average reference duration of stages in word production, and we saw that the offset EVS may accommodate for more than the articulatory programming stage of word N.

Abstract

Two different forms of parafoveal dysfunction have been hypothesized as core deficits of dyslexic individuals: reduced parafoveal preview benefits (“too little parafovea”) and increased costs of parafoveal load (“too much parafovea”). We tested both hypotheses in a single eye-tracking experiment using a modified serial rapid automatized naming (RAN) task. Comparisons between dyslexic and non-dyslexic adults showed reduced parafoveal preview benefits in dyslexics, without increased costs of parafoveal load. Reduced parafoveal preview benefits were observed in a naming task, but not in a silent letter-finding task, indicating that the parafoveal dysfunction may be consequent to the overload with extracting phonological information from orthographic input. Our results suggest that dyslexics’ parafoveal dysfunction is not based on strict visuo-attentional factors, but nevertheless they stress the importance of extra-phonological processing. Furthermore, evidence of reduced parafoveal preview benefits in dyslexia may help understand why serial RAN is an important reading predictor in adulthood

Abstract

ELAN is a multimedia annotation tool developed by the Max Planck Institute for Psycholinguistics. It is applied in a variety of research areas. This paper presents a general overview of the tool and new developments as the calculation of inter-rater reliability, a commentary framework, semi-automatic segmentation and labeling and export to Theme.

Abstract

The spinocerebellar ataxias (SCAs) form an ever-growing group of neurodegenerative disorders causing dysfunction of the cerebellum and loss of motor control in patients. Currently, 41 different genetic causes have been identified, with each mutation affecting a different gene. Interestingly, these diverse genetic causes all disrupt cerebellar function and produce similar symptoms in patients. In order to understand the disease better, and define possible therapeutic targets for multiple SCAs, the field has been searching for common ground among the SCAs. In this review, we discuss the physiology of climbing fibers and the possibility that climbing fiber dysfunction is a point of convergence for at least a subset of SCAs.

Abstract

Spinocerebellar ataxia type 23 (SCA23) is caused by missense mutations in prodynorphin, encoding the precursor protein for the opioid neuropeptides a -neoendorphin, Dynorphin (Dyn) A and Dyn B, leading to neurotoxic elevated mutant Dyn A levels. Dyn A acts on opioid receptors to reduce pain in the spinal cord, but its cerebellar function remains largely unknown. Increased concentration of or prolonged exposure to Dyn A is neurotoxic and these deleterious effects are very likely caused by an N - methyl- D -aspartate-mediated non-opioid mechanism as Dyn A peptides were shown to bind NMDA receptors and potentiate their glutamate-evoked currents. In the present study, we investigated the cellular mechanisms underlying SCA23-mutant Dyn A neurotoxicity. We show that SCA23 mutations in the Dyn A-coding region disrupted peptide secondary structure leading to a loss of the N-terminal a -helix associated with decreased j -opioid receptor affinity. Additionally, the altered secondary structure led to increased peptide stability of R6W and R9C Dyn A, as these peptides showed marked degradation resistance, which coin- cided with decreased peptide solubility. Notably, L5S Dyn A displayed increased degradation and no aggregation. R6W and wt Dyn A peptides were most toxic to primary cerebellar neurons. For R6W Dyn A, this is likely because of a switch from opioid to NMDA- receptor signalling, while for wt Dyn A, this switch was not observed. We propose that the pathology of SCA23 results from converging mechanisms of loss of opioid-mediated neuroprotection and NMDA-mediated excitotoxicity.

Abstract

Computational models can reflect the complexity of human behaviour by implementing multiple constraints within their architecture, and/or by taking into account the variety and richness of the environment to which the human is responding. We explore the second alternative in a model of word recognition that learns to map spoken words to visual and semantic representations of the words’ concepts. Critically, we employ a phonological representation utilising coarse-coding of the auditory stream, to mimic early stages of language development that are not dependent on individual phonemes to be isolated in the input, which may be a consequence of literacy development. The model was tested at different stages during training, and was able to simulate key behavioural features of word recognition in children: a developing effect of semantic information as a consequence of language learning, and a small but earlier effect of phonological information on word processing. We additionally tested the role of visual information in word processing, generating predictions for behavioural studies, showing that visual information could have a larger effect than semantics on children’s performance, but that again this affects recognition later in word processing than phonological information. The model also provides further predictions for performance of a mature word recognition system in the absence of fine-coding of phonology, such as in adults who have low literacy skills. The model demonstrated that such phonological effects may be reduced but are still evident even when multiple distractors from various modalities are present in the listener’s environment. The model demonstrates that complexity in word recognition can emerge from a simple associative system responding to the interactions between multiple sources of information in the language learner’s environment.

Abstract

A quantitative model of human categorization behavior is proposed, which can be applied to 4-alternative forced-choice categorization data involving two binary classifications. A number of processing dependencies between the two classifications are explicitly formulated, such as the dependence of the location, orientation, and steepness of the class boundary for one classification on the outcome of the other classification. The significance of various types of dependencies can be tested statistically. Analyses of a data set from the literature shows that interesting dependencies in human speech recognition can be uncovered using the model.

Abstract

This article is concerned with the question of how listeners recognize coarticulated phonemes. The problem is approached from a pattern classificationperspective. First, the potential acoustical effects of coarticulation are defined in terms of the patterns that form the input to a classifier.Next, a categorization model called HICAT is introduced that incorporates hierarchical dependencies to optimally dealwith this input. The model allows the position, orientation, and steepness of one phoneme boundary to depend on the perceivedvalue of a neighboring phoneme. It is argued that, if listeners do behave like statistical pattern recognizers, they may use the categorization strategies incorporated in the model. The HICAT model is compared with existing categorizationmodels, among which are the fuzzylogical model of perception and Nearey’s diphone-biased secondary-cuemodel. Finally, a method is presented by which categorization strategies that are likely to be used by listeners can be predicted from distributions of acoustical cues as they occur in natural speech.

Abstract

The reported research investigates how listeners recognize coarticulated phonemes. First, 2 data sets from experiments on the recognition of coarticulated phonemes published by D. H. Whalen (1989) are reanalyzed. The analyses indicate that listeners used categorization strategies involving a hierarchical dependency. Two new experiments are reported investigating the production and perception of fricative-vowel syllables. On the basis of measurements of acoustic cues on a large set of natural utterances, it was predicted that listeners would use categorization strategies involving a dependency of the fricative categorization on the perceived vowel. The predictions were tested in a perception experiment using a 2-dimensional synthetic fricative-vowel continuum. Model analyses of the results pooled across listeners confirmed the predictions. Individual analyses revealed some variability in the categorization dependencies used by different participants.

Abstract

De novo disruptions of the neural transcription factor FOXP1 are a recently discovered, rare cause of sporadic intellectual disability (ID). We report three new cases of FOXP1-related disorder identified through clinical whole-exome sequencing. Detailed phenotypic assessment confirmed that global developmental delay, autistic features, speech/language deficits, hypotonia and mild dysmorphic features are core features of the disorder. We expand the phenotypic spectrum to include sensory integration disorder and hypertelorism. Notably, the etiological variants in these cases include two missense variants within the DNA-binding domain of FOXP1. Only one such variant has been reported previously. The third patient carries a stop-gain variant. We performed functional characterization of the three missense variants alongside our stop-gain and two previously described truncating/frameshift variants. All variants severely disrupted multiple aspects of protein function. Strikingly, the missense variants had similarly severe effects on protein function as the truncating/frameshift variants. Our findings indicate that a loss of transcriptional repression activity of FOXP1 underlies the neurodevelopmental phenotype in FOXP1-related disorder. Interestingly, the three novel variants retained the ability to interact with wild-type FOXP1, suggesting these variants could exert a dominant-negative effect by interfering with the normal FOXP1 protein. These variants also retained the ability to interact with FOXP2, a paralogous transcription factor disrupted in rare cases of speech and language disorder. Thus, speech/language deficits in these individuals might be worsened through deleterious effects on FOXP2 function. Our findings highlight that de novo FOXP1 variants are a cause of sporadic ID and emphasize the importance of this transcription factor in neurodevelopment.

Abstract

Four cross-modal priming experiments in Spanish addressed the role of suprasegmental and segmental information in the activation of spoken words. Listeners heard neutral sentences ending with word fragments (e.g., princi-) and made lexical decisions on letter strings presented at fragment offset. Responses were compared for fragment primes that fully matched the spoken form of the initial portion of target words, versus primes that mismatched in a single element (stress pattern; one vowel; one consonant), versus control primes. Fully matching primes always facilitated lexical decision responses, in comparison to the control condition, while mismatching primes always produced inhibition. The respective strength of the contribution of stress, vowel, and consonant (one feature mismatch or more) information did not differ statistically. The results support a model of spoken-word recognition involving automatic activation of word forms and competition between activated words, in which the activation process is sensitive to all acoustic information relevant to the language’s phonology.

Abstract

We conceptualize objects based on sensory and motor information gleaned from real-world experience. But to what extent is such conceptual information structured according to higher level linguistic features too? Here we investigate whether classifiers, a grammatical category, shape the conceptual representations of objects. In three experiments native Mandarin speakers (speakers of a classifier language) and native Dutch speakers (speakers of a language without classifiers) judged the similarity of a target object (presented as a word or picture) with four objects (presented as words or pictures). One object shared a classifier with the target, the other objects did not, serving as distractors. Across all experiments, participants judged the target object as more similar to the object with the shared classifier than distractor objects. This effect was seen in both Dutch and Mandarin speakers, and there was no difference between the two languages. Thus, even speakers of a non-classifier language are sensitive to object similarities underlying classifier systems, and using a classifier system does not exaggerate these similarities. This suggests that classifier systems simply reflect, rather than affect, conceptual structure.

Abstract

Language interacts with olfaction in exceptional ways. Olfaction is believed to be weakly linked with language, as demonstrated by our poor odor naming ability, yet olfaction seems to be particularly susceptible to linguistic descriptions. We tested the boundaries of the influence of language on olfaction by focusing on a non-lexical aspect of language (grammatical gender). We manipulated the grammatical gender of fragrance descriptions to test whether the congruence with fragrance gender would affect the way fragrances were perceived and remembered. Native French and German speakers read descriptions of fragrances containing ingredients with feminine or masculine grammatical gender, and then smelled masculine or feminine fragrances and rated them on a number of dimensions (e.g., pleasantness). Participants then completed an odor recognition test. Fragrances were remembered better when presented with descriptions whose grammatical gender matched the gender of the fragrance. Overall, results suggest grammatical manipulations of odor descriptions can affect odor cognition

Abstract

The current study investigated the influence of a play-based curriculum on the development of pretend play skills and oral language in children attending their first year of formal schooling. In this quasi-experimental design, two groups of children were followed longitudinally across the first 6 months of their first year at school. The children in the experimental group were attending a school with a play-based curriculum; the children in the control group were attending schools following a traditional curriculum. A total of 54 children (Time 1 Mage = 5;6, range: 4;10–6;2 years) completed standardised measures of pretend play and narrative language skills upon school entry and again 6 months later. The results showed that the children in the play-based group significantly improved on all measures, whereas the children in the traditional group did not. A subset of the sample of children (N = 28, Time 1 Mage = 5;7, range: 5;2 – 6;1) also completed additional measures of vocabulary and grammar knowledge, and a test of non-verbal IQ. The results suggested that, in addition to improving play skills and narrative language ability, the play-based curriculum also had a positive influence on the acquisition of grammar.

Abstract

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Cleft Palate-Craniofacial Journal
Volume 53, Issue 3, May 2016, Pages 317-325
Opportunities and challenges in establishing a cohort study: An example from cleft lip/palate research in the United Kingdom (Article)
Stock, N.M.a ,
Humphries, K.b,
St. Pourcain, B.b,
Bailey, M.b,
Persson, M.a,
Ho, K.M.b,
Ring, S.b,
Marsh, C.c,
Albery, L.c,
Rumsey, N.a,
Sandy, J.b


a Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, United Kingdom
b Faculty of Medicine and Dentistry, University of Bristol, United Kingdom
c South West Cleft Service, University Hospitals Bristol NHS Foundation Trust, United Kingdom
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View references (32)
Abstract

Background: Cleft lip and/or palate (CL/P) is one of the most common birth conditions in the world, but little is known about its causes. Professional opinion remains divided as to which treatments may be the most beneficial for patients with CL/P, and the factors that contribute to psychological adjustment are poorly understood. The use of different methodological approaches and tools plays a key role in hampering efforts to address discrepancies within the evidence base. A new UK-wide program of research, The Cleft Collective, was established to combat many of these methodological challenges and to address some of the key research questions important to all CL/P stakeholders. Objective: To describe the establishment of CL/P cohort studies in the United Kingdom and to consider the many opportunities this resource will generate. Results: To date, protocols have been developed and implemented within most UK cleft teams. Biological samples, environmental information, and data pertaining to parental psychological well-being and child development are being collected successfully. Recruitment is currently on track to meet the ambitious target of approximately 9800 individuals from just more than 3000 families. Conclusions: The Cleft Collective cohort studies represent a significant step forward for research in the field of CL/P. The data collected will form a comprehensive resource of information about individuals with CL/P and their families. This resource will provide the basis for many future projects and collaborations, both in the United Kingdom and around the world.

Abstract

Previous studies show that children do not become adult-like in learning to set the scene and introduce referents in their narrations until 9 years of age and even beyond. However, they investigated spoken languages, thus we do not know much about how these skills are acquired in sign languages, where events are expressed in visually similar ways to the real world events, unlike in spoken languages. The results of the current study demonstrate that deaf children (3;5–9;10 years) acquiring Turkish Sign Language, and hearing children (3;8–9;11 years) acquiring spoken Turkish both acquire scene-setting and referent introduction skills at similar ages. Thus the modality of the language being acquired does not have facilitating or hindering effects in the development of these skills.

Abstract

This study investigates whether spoken sentence comprehension deficits in Broca's aphasics results from their inability to access the subordinate meaning of ambiguous words (e.g. bank), or alternatively, from a delay in their selection of the contextually appropriate meaning. Twelve Broca's aphasics and twelve elderly controls were presented with lexical ambiguities in three context conditions, each followed by the same target words. In the concordant condition, the sentence context biased the meaning of the sentence final ambiguous word that was related to the target. In the discordant condition, the sentence context biased the meaning of the sentence final ambiguous word that was incompatible with the target.In the unrelated condition, the sentence-final word was unambiguous and unrelated to the target. The task of the subjects was to listen attentively to the stimuli The activational status of the ambiguous sentence-final words was inferred from the amplitude of the N399 to the targets at two inter-stimulus intervals (ISIs) (100 ms and 1250 ms). At the short ISI, the Broca's aphasics showed clear evidence of activation of the subordinate meaning. In contrast to elderly controls, however, the Broca's aphasics were not successful at selecting the appropriate meaning of the ambiguity in the short ISI version of the experiment. But at the long ISI, in accordance with the performance of the elderly controls, the patients were able to successfully complete the contextual selection process. These results indicate that Broca's aphasics are delayed in the process of contextual selection. It is argued that this finding of delayed selection is compatible with the idea that comprehension deficits in Broca's aphasia result from a delay in the process of integrating lexical information.

Abstract

This volume on Inuit speech follows the evolution of a native language of the North American Arctic, from its historical roots to its present-day linguistic structure and patterns of use from Alaska to Greenland. Drawing on a wide range of research from the fields of linguistics, anthropology, and sociology, Dorais integrates these diverse perspectives in a comprehensive view of native language development, maintenance, and use under conditions of marginalization due to social transition.

Abstract

Printed text can be decoded by utilizing different processing routes depending on the familiarity of the script. A predominant use of word-level decoding strategies can be expected in the case of a familiar script, and an almost exclusive use of letter-level decoding strategies for unfamiliar scripts. Behavioural studies have revealed that frequently occurring words are read more efficiently, suggesting that these words are read in a more holistic way at the word-level, than infrequent and unfamiliar words. To test whether repeated exposure to specific letter combinations leads to holistic reading, we monitored both behavioural and neural responses during novel script decoding and examined changes related to repeated exposure. We trained a group of Dutch university students to decode pseudowords written in an unfamiliar script, i.e., Korean Hangul characters. We compared behavioural and neural responses to pronouncing trained versus untrained two-character pseudowords (equivalent to two-syllable pseudowords). We tested once shortly after the initial training and again after a four days' delay that included another training session. We found that trained pseudowords were pronounced faster and more accurately than novel combinations of radicals (equivalent to letters). Imaging data revealed that pronunciation of trained pseudowords engaged the posterior temporo-parietal region, and engagement of this network was predictive of reading efficiency a month later. The results imply that repeated exposure to specific combinations of graphemes can lead to emergence of holistic representations that result in efficient reading. Furthermore, inter-individual differences revealed that good learners retained efficiency more than bad learners one month later

Abstract

It is well documented that emotionally arousing experiences are better remembered than mundane events. This is thought to occur through hippocampus-amygdala crosstalk during encoding, consolidation, and retrieval. Here we investigated whether emotional events (context) also cause a memory benefit for simultaneously encoded non-arousing contents and whether this effect persists after a delay via recruitment of a similar hippocampus-amygdala network. Participants studied neutral pictures (content) encoded together with either an arousing or a neutral sound (that served as context) in two study sessions three days apart. Memory was tested in a functional magnetic resonance scanner directly after the second study session. Pictures recognised with high confidence were more often thought to have been associated with an arousing than with a neutral context, irrespective of the veridical source memory. If the retrieved context was arousing, an area in the hippocampus adjacent to the amygdala exhibited heightened activation and this area increased functional connectivity with the parahippocampal gyrus, an area known to process pictures of scenes. These findings suggest that memories can be shaped by the retrieval act. Memory structures may be recruited to a higher degree when an arousing context is retrieved, and this may give rise to confident judgments of recognition for neutral pictures even after a delay

Abstract

This paper combines two different approaches to modeling reaction time data from lexical decision experiments, viz. a dataoriented statistical analysis by means of a linear mixed effects model, and a process-oriented computational model of human speech comprehension. The linear mixed effect model is implemented by lmer in R. As computational model we apply DIANA, an end-to-end computational model which aims at modeling the cognitive processes underlying speech comprehension. DIANA takes as input the speech signal, and provides as output the orthographic transcription of the stimulus, a word/non-word judgment and the associated reaction time. Previous studies have shown that DIANA shows good results for large-scale lexical decision experiments in Dutch and North-American English. We investigate whether predictors that appear significant in an lmer analysis and processes implemented in DIANA can be related and inform both approaches. Predictors such as ‘previous reaction time’ can be related to a process description; other predictors, such as ‘lexical neighborhood’ are hard-coded in lmer and emergent in DIANA. The analysis focuses on the interaction between subject variables and task variables in lmer, and the ways in which these interactions can be implemented in DIANA.

Abstract

Stimulus categorization is influenced by oscillations in the brain. For example, we have shown that ongoing oscillatory phase biases identification of an ambiguous syllable that can either be perceived as /da/ or /ga/. This suggests that phase is a cue for the brain to determine syllable identity and this cue could be an element of the representation of these syllables. If so, brain activation patterns for /da/ should be more unique when the syllable is presented at the /da/ biasing (i.e. its "preferred") phase. To test this hypothesis we presented non-ambiguous /da/ and /ga/ syllables at either their preferred or non-preferred phase ( using sensory entrainment) while measuring 7T fMRI. Using multivariate pattern analysis in auditory regions we show that syllable decoding performance is higher when syllables are presented at their preferred compared to their non-preferred phase. These results suggest that phase information increases the distinctiveness of /da/ and /ga/ brain activation patterns. (C) 2016 Elsevier Inc. All rights reserved.

Abstract

In spontaneous conversations, words are often produced in reduced form compared to formal careful speech. In English, for instance, ’probably’ may be pronounced as ’poly’ and ’police’ as ’plice’. Reduced forms are very common, and native listeners usually do not have any problems with interpreting these reduced forms in context. Non-native listeners, however, have great difficulties in comprehending reduced forms. In order to investigate the problems in comprehension that non-native listeners experience, a dictation experiment was conducted in which sentences were presented auditorily to non-natives either in full (unreduced) or reduced form. The types of errors made by the L2 listeners reveal aspects of the cognitive processes underlying this dictation task. In addition, we compare the errors made by these human participants with the type of word errors made by DIANA, a recently developed computational model of word comprehension.

Abstract

Our understanding of how perception operates in real-world environments has been substantially advanced by studying both multisensory processes and "top-down" control processes influencing sensory processing via activity from higher-order brain areas, such as attention, memory, and expectations. As the two topics have been traditionally studied separately, the mechanisms orchestrating real-world multisensory processing remain unclear. Past work has revealed that the observer's goals gate the influence of many multisensory processes on brain and behavioural responses, whereas some other multisensory processes might occur independently of these goals. Consequently, other forms of top-down control beyond goal dependence are necessary to explain the full range of multisensory effects currently reported at the brain and the cognitive level. These forms of control include sensitivity to stimulus context as well as the detection of matches (or lack thereof) between a multisensory stimulus and categorical attributes of naturalistic objects (e.g. tools, animals). In this review we discuss and integrate the existing findings that demonstrate the importance of such goal-, object- and context-based top-down control over multisensory processing. We then put forward a few principles emerging from this literature review with respect to the mechanisms underlying multisensory processing and discuss their possible broader implications.

Abstract

In recent years, it has become increasingly clear that both the power and phase of oscillatory brain activity can influence the processing and perception of sensory stimuli. Transcranial alternating current stimulation (tACS) can phase-align and amplify endogenous brain oscillations and has often been used to control and thereby study oscillatory power. Causal investigation of oscillatory phase is more difficult, as it requires precise real-time temporal control over both oscillatory phase and sensory stimulation. Here, we present hardware and software solutions allowing temporally precise presentation of sensory stimuli during tACS at desired tACS phases, enabling causal investigations of oscillatory phase. We developed freely available and easy to use software, which can be coupled with standard commercially available hardware to allow flexible and multi-modal stimulus presentation (visual, auditory, magnetic stimuli, etc.) at pre-determined tACS-phases, opening up a range of new research opportunities. We validate that stimulus presentation at tACS phase in our setup is accurate to the sub-millisecond level with high inter-trial consistency. Conventional methods investigating the role of oscillatory phase such as magneto-/electroencephalography can only provide correlational evidence. Using brain stimulation with the described methodology enables investigations of the causal role of oscillatory phase. This setup turns oscillatory phase into an independent variable, allowing innovative, and systematic studies of its functional impact on perception and cognition.

Abstract

This work presents a salvage grammar of the Biri language of Eastern Central Queensland, a Pama-Nyungan language belonging to the large Maric subgroup. As the language is no longer used, the grammatical description is based on old written sources and on recordings made by linguists in the 1960s and 1970s. Biri is in many ways typical of the Pama-Nyungan languages of Southern Queensland. It has split case marking systems, marking nouns according to an ergative/absolutive system and pronouns according to a nominative/accusative system. Unusually for its area, Biri also has bound pronouns on its verb, cross-referencing the person, number and case of core participants. As far as it is possible, the grammatical discussion is ‘theory neutral’. The first four chapters deal with the phonology, morphology, and syntax of the language. The last two chapters contain a substantial discussion of Biri’s place in the Pama-Nyungan family. In chapter 6 the numerous dialects of the Biri language are discussed. In chapter 7 the close linguistic relationship between Biri and the surrounding languages is examined.

Abstract

The first part of this paper describes an unusual system of anaphoric reference tracking in Lavukaleve, a Papuan language of the Solomon Islands. Lavukaleve has two demonstrative pronouns which can be used to make anaphoric reference in narratives. One of these demonstrative pronouns is used to make anaphoric reference to a semi-activated participant, and the other to an activated participant. The second part of the paper situates Lavukaleve's activation-based system of reference tracking in a general typology of reference tracking. Other languages which have reference tracking systems based on the cognitive status of the referent are discussed, and the close connection between these and obviation systems is pointed out.

Abstract

Providing the neurobiological basis of information processing in higher animals, spiking neural networks must be able to learn a variety of complicated computations, including the generation of appropriate, possibly delayed reactions to inputs and the self-sustained generation of complex activity patterns, e.g. for locomotion. Many such computations require previous building of intrinsic world models. Here we show how spiking neural networks may solve these different tasks. Firstly, we derive constraints under which classes of spiking neural networks lend themselves to substrates of powerful general purpose computing. The networks contain dendritic or synaptic nonlinearities and have a constrained connectivity. We then combine such networks with learning rules for outputs or recurrent connections. We show that this allows to learn even difficult benchmark tasks such as the self-sustained generation of desired low-dimensional chaotic dynamics or memory-dependent computations. Furthermore, we show how spiking networks can build models of external world systems and use the acquired knowledge to control them.

Abstract

This study investigates the role of performance limitations in children's early acquisition of verb-argument structure. Valian (1991) claims that intransitive frames are easier for children to produce early in development than transitive frames because they do not require a direct object argument. Children who understand this distinction are expected to produce a lower proportion of transitive verb utterances early in development in comparison with later stages of development and to omit direct objects much more frequently with mixed verbs (where direct objects are optional) than with transitive verbs. To test these claims, data from nine children aged between 1;10.7 and 2;0.25 matched with Valian's subjects on MLU were examined. When analysed in terms of abstract syntactic structures Valian's findings are supported. However, a detailed lexical analysis of the data suggests that the children were not selecting argument structure on the basis of syntactic complexity. Instead, a clear predictor of the frames used by the children with specific verbs was the frames used by the children's mothers with those same verbs, regardless of whether they were transitive or intransitive. This suggests that the most important determinant of the children's use of verb frame was the specific patterns of verb use in the input rather than abstract grammatical knowledge constrained by performance limitations. The implications of these findings for performance-based explanations for children's early errors and early patterns of language use are discussed.

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental condition with a clear, but heterogeneous, genetic component. Germline mutations in the tumor suppressor Pten are a well-established risk factor for ASD with macrocephaly, and conditional Pten mouse models have impaired social behavior and brain development. Some mutations observed in patients disrupt the normally balanced nuclear-cytoplasmic localization of the Pten protein, and we developed the Ptenm3m4 model to study the effects of a cytoplasm-predominant Pten. In this model, germline mislocalization of Pten causes inappropriate social behavior with intact learning and memory, a profile reminiscent of high-functioning ASD. These animals also exhibit histological evidence of neuroinflammation and expansion of glial populations by 6 weeks of age. We hypothesized that the neural transcriptome of this model would be altered in a manner that could inform human idiopathic ASD, a constitutional condition. Using total RNA sequencing, we found progressive disruption of neural gene expression in Ptenm3m4 mice from 2–6 weeks of age, involving both immune and synaptic pathways. These alterations include downregulation of many highly coexpressed human ASD-susceptibility genes. Comparison with a human cortical development coexpression network revealed that genes disrupted in Ptenm3m4 mice were enriched in the same areas as those of human ASD. Although Pten-related ASD is relatively uncommon, our observations suggest that the Ptenm3m4 model recapitulates multiple molecular features of human ASD, and that Pten operates far upstream of common pathways within ASD pathogenesis.

Abstract

This paper describes the development of a CLARIN-compatible repository solution that fulfils
both the long-term preservation requirements as well as the current day discoverability and usability
needs of an online data repository of language resources. The widely used Fedora Commons
open source repository framework, combined with the Islandora discovery layer, forms
the basis of the solution. On top of this existing solution, additional modules and tools are developed
to make it suitable for the types of data and metadata that are used by the participating
partners.

Abstract

Fluctuations in pupil size have been shown to reflect variations in processing demands during lexical and syntactic processing in language comprehension. An issue that has not received attention is whether pupil size also varies due to pragmatic manipulations. In two pupillometry experiments, we investigated whether pupil diameter was sensitive to increased processing demands as a result of comprehending an indirect request versus a direct statement. Adult participants were presented with 120 picture–sentence combinations that could be interpreted either as an indirect request (a picture of a window with the sentence “it's very hot here”) or as a statement (a picture of a window with the sentence “it's very nice here”). Based on the hypothesis that understanding indirect utterances requires additional inferences to be made on the part of the listener, we predicted a larger pupil diameter for indirect requests than statements. The results of both experiments are consistent with this expectation. We suggest that the increase in pupil size reflects additional processing demands for the comprehension of indirect requests as compared to statements. This research demonstrates the usefulness of pupillometry as a tool for experimental research in pragmatics

Abstract

Although toddlers in their 2nd year of life generally have phonologically detailed representations of words, a consistent lack of sensitivity to certain kinds of phonological changes has been reported. The origin of these insensitivities is poorly understood, and uncovering their cause is crucial for obtaining a complete picture of early phonological development. The present study explored the origins of the insensitivity to the change from coronal to labial consonants. In cross-linguistic research, we assessed to what extent this insensitivity is language-specific (or would show both in learners of Dutch and a very different language like Japanese), and contrast/direction-specific to the coronal-to-labial change (or would also extend to the coronal-to-dorsal change). We measured Dutch and Japanese 18-month-old toddlers' sensitivity to labial and dorsal mispronunciations of newly learned coronal-initial words. Both Dutch and Japanese toddlers showed reduced sensitivity to the coronal-to-labial change, although this effect was more pronounced in Dutch toddlers. The lack of sensitivity was also specific to the coronal-to-labial change because toddlers from both language backgrounds were highly sensitive to dorsal mispronunciations. Combined with results from previous studies, the present outcomes are most consistent with an early, language-general bias specific to the coronal-to-labial change, which is modified by the properties of toddlers' early, language-specific lexicon

Abstract

The majority of studies addressing psycholinguistic questions focus on speech produced and processed in a careful, laboratory speech style. This ‘careful’ speech is very different from the speech that listeners encounter in casual conversations. This article argues that research on casual speech is necessary to show the validity of conclusions based on careful speech. Moreover, research on casual speech produces new insights and questions on the processes underlying communication and on the mental lexicon that cannot be revealed by research using careful speech. This article first places research on casual speech in its historic perspective. It then provides many examples of how casual speech differs from careful speech and shows that these differences may have important implications for psycholinguistic theories. Subsequently, the article discusses the challenges that research on casual speech faces, which stem from the high variability of this speech style, its necessary casual context, and that casual speech is connected speech. We also present opportunities for research on casual speech, mostly in the form of new experimental methods that facilitate research on connected speech. However, real progress can only be made if these new methods are combined with advanced (still to be developed) statistical techniques.

Abstract

This volume presents peer-reviewed versions of papers presented at the 14th Neural Computation and Psychology Workshop (NCPW14), which took place in July 2014 at Lancaster University, UK. The workshop draws international attendees from the cutting edge of interdisciplinary
research in psychology, computational modeling, artificial intelligence and psychology, and aims to drive forward
our understanding of the mechanisms underlying a range of cognitive processes.

Abstract

We examined side preferences in the Florida manatee (Trichechus manatus latirostris) through observations of limb use (right and left flipper) in 123 wild and 16 captive individuals. We also analyzed archival data, the United States Geological Survey Sirenia ProjectManatee Individual Photo-identification Systemdataset, to determine lateralization of evasive action from boats. Wild and captive manatees displayed flipper lateralization at the individual, but not the population level for several behaviors including substrate touches, sculling, and feeding. In contrast, manatees were lateralized at the population level for boat-scar biases,with more manatees showing a left scar bias (45.3%) versus right (34.3%) or dorsal/ambipreferent (20.3%).

Abstract

The paper reports the results of a learnability experiment with German speakers, investigating the role of universal phonotactic constraints and language use in language processing. Making use of an artificial language paradigm, participants learned nonce words with existent and non-existent German final consonant clusters adhering to or violating sonority sequencing principles postulated for consonant clusters. Behavioural data and event-related brain potentials in response to these cluster properties were obtained twice, before and after learning word-picture-pairs. The results show (1) that learning and processing of final consonant clusters is facilitated by adherence to the sonority hierarchy, and (2) that actual existence of well- and ill-formed consonant clusters aids processing mechanisms. Thus, both implicit knowledge of universal phonotactic principles and frequency-based factors are demonstrated to play a role in the online-processing of words.

Abstract

When monitoring the origins of their memories, people tend to mistakenly attribute mem- ories generated from internal processes (e.g., imagination, visualization) to perception. Here, we ask whether speaking a language that obligatorily encodes the source of informa- tion might help prevent such errors. We compare speakers of English to speakers of Turkish, a language that obligatorily encodes information source (direct/perceptual vs. indirect/hearsay or inference) for past events. In our experiments, participants reported having seen events that they had only inferred from post-event visual evidence. In general, error rates were higher when visual evidence that gave rise to inferences was relatively close to direct visual evidence. Furthermore, errors persisted even when participants were asked to report the specific sources of their memories. Crucially, these error patterns were equivalent across language groups, suggesting that speaking a language that obligatorily encodes source of information does not increase sensitivity to the distinction between per- ception and inference in event memory.

Abstract

It has long been recognized that language interacts with visual and spatial processes. However, the nature and extent of these interactions are widely debated. The goal of this article is to review empirical findings across several domains to understand whether language affects the way speakers conceptualize the world even when they are not speaking or understanding speech. A second goal of the present review is to shed light on the mechanisms through which effects of language are transmitted. Across domains, there is growing support for the idea that although language does not lead to long-lasting changes in mental representations, it exerts powerful influences during momentary mental computations by either modulating attention or augmenting representational power