Publications

Displaying 501 - 529 of 529
  • Verkerk, A., & Frostad, B. H. (2013). The encoding of manner predications and resultatives in Oceanic: A typological and historical overview. Oceanic Linguistics, 52, 1-35. doi:10.1353/ol.2013.0010.

    Abstract

    This paper is concerned with the encoding of resultatives and manner predications in Oceanic languages. Our point of departure is a typological overview of the encoding strategies and their geographical distribution, and we investigate their historical traits by the use of phylogenetic comparative methods. A full theory of the historical pathways is not always accessible for all the attested encoding strategies, given the data available for this study. However, tentative theories about the development and origin of the attested strategies are given. One of the most frequent strategy types used to encode both manner predications and resultatives has been given special emphasis. This is a construction in which a reex form of the Proto-Oceanic causative *pa-/*paka- modies the second verb in serial verb constructions

    Additional information

    52.1.verkerk_supp01.pdf
  • Verkerk, A. (2013). Scramble, scurry and dash: The correlation between motion event encoding and manner verb lexicon size in Indo-European. Language Dynamics and Change, 3, 169-217. doi:10.1163/22105832-13030202.

    Abstract

    In recent decades, much has been discovered about the different ways in which people can talk about motion (Talmy, 1985, 1991; Slobin, 1996, 1997, 2004). Slobin (1997) has suggested that satellite-framed languages typically have a larger and more diverse lexicon of manner of motion verbs (such as run, fly, and scramble) when compared to verb-framed languages. Slobin (2004) has claimed that larger manner of motion verb lexicons originate over time because codability factors increase the accessibility of manner in satellite-framed languages. In this paper I investigate the dependency between the use of the satellite-framed encoding construction and the size of the manner verb lexicon. The data used come from 20 Indo-European languages. The methodology applied is a range of phylogenetic comparative methods adopted from biology, which allow for an investigation of this dependency while taking into account the shared history between these 20 languages. The results provide evidence that Slobin’s hypothesis was correct, and indeed there seems to be a relationship between the use of the satellite-framed construction and the size of the manner verb lexicon
  • von Stutterheim, C., Flecken, M., & Carroll, M. (2013). Introduction: Conceptualizing in a second language. International Review of Applied Linguistics in Language Teaching, 51(2), 77-85. doi:10.1515/iral-2013-0004.
  • von Stutterheim, C., & Flecken, M. (Eds.). (2013). Principles of information organization in L2 discourse [Special Issue]. International Review of Applied linguistics in Language Teaching (IRAL), 51(2).
  • De Vos, C. (2013). Sign-Spatiality in Kata Kolok: How a village sign language of Bali inscribes its signing space [Dissertation abstract]. Sign Language & Linguistics, 16(2), 277-284. doi:10.1075/sll.16.2.08vos.
  • De Vriend, F., Broeder, D., Depoorter, G., van Eerten, L., & Van Uytvanck, D. (2013). Creating & Testing CLARIN Metadata Components. Language Resources and Evaluation, 47(4), 1315-1326. doi:10.1007/s10579-013-9231-6.

    Abstract

    The CLARIN Metadata Infrastructure (CMDI) that is being developed in Common Language Resources and Technology Infrastructure (CLARIN) is a computer-supported framework that combines a flexible component approach with the explicit declaration of semantics. The goal of the Dutch CLARIN project “Creating & Testing CLARIN Metadata Components” was to create metadata components and profiles for a wide variety of existing resources housed at two data centres according to the CMDI specifications. In doing so the principles of the framework were tested. The results of the project are of benefit to other CLARIN-projects that are expected to adhere to the CMDI framework and its accompanying tools.
  • Wagensveld, B., Segers, E., Van Alphen, P. M., & Verhoeven, L. (2013). The role of lexical representations and phonological overlap in rhyme judgments of beginning, intermediate and advanced readers. Learning and Individual Differences, 23, 64-71. doi:10.1016/j.lindif.2012.09.007.

    Abstract

    Studies have shown that prereaders find globally similar non-rhyming pairs (i.e., bell–ball) difficult to judge. Although this effect has been explained as a result of ill-defined lexical representations, others have suggested that it is part of an innate tendency to respond to phonological overlap. In the present study we examined this effect over time. Beginning, intermediate and advanced readers were presented with a rhyme judgment task containing rhyming, phonologically similar, and unrelated non-rhyming pairs. To examine the role of lexical representations, participants were presented with both words and pseudowords. Outcomes showed that pseudoword processing was difficult for children but not for adults. The global similarity effect was present in both children and adults. The findings imply that holistic representations cannot explain the incapacity to ignore similarity relations during rhyming. Instead, the data provide more evidence for the idea that global similarity processing is part of a more fundamental innate phonological processing capacity.
  • Wagensveld, B., Van Alphen, P. M., Segers, E., Hagoort, P., & Verhoeven, L. (2013). The neural correlates of rhyme awareness in preliterate and literate children. Clinical Neurophysiology, 124, 1336-1345. doi:10.1016/j.clinph.2013.01.022.

    Abstract

    Objective Most rhyme awareness assessments do not encompass measures of the global similarity effect (i.e., children who are able to perform simple rhyme judgments get confused when presented with globally similar non-rhyming pairs). The present study examines the neural nature of this effect by studying the N450 rhyme effect. Methods Behavioral and electrophysiological responses of Dutch pre-literate kindergartners and literate second graders were recorded while they made rhyme judgments of word pairs in three conditions; phonologically rhyming (e.g., wijn-pijn), overlapping non-rhyming (e.g., pen-pijn) and unrelated non-rhyming pairs (e.g., boom-pijn). Results Behaviorally, both groups had difficulty judging overlapping but not rhyming and unrelated pairs. The neural data of second graders showed overlapping pairs were processed in a similar fashion as unrelated pairs; both showed a more negative deflection of the N450 component than rhyming items. Kindergartners did not show a typical N450 rhyme effect. However, some other interesting ERP differences were observed, indicating preliterates are sensitive to rhyme at a certain level. Significance Rhyme judgments of globally similar items rely on the same process as rhyme judgments of rhyming and unrelated items. Therefore, incorporating a globally similar condition in rhyme assessments may lead to a more in-depth measure of early phonological awareness skills. Highlights Behavioral and electrophysiological responses were recorded while (pre)literate children made rhyme judgments of rhyming, overlapping and unrelated words. Behaviorally both groups had difficulty judging overlapping pairs as non-rhyming while overlapping and unrelated neural patterns were similar in literates. Preliterates show a different pattern indicating a developing phonological system.
  • Wagner, A. (2013). Cross-language similarities and differences in the uptake of place information. Journal of the Acoustical Society of America, 133, 4256-4267. doi:10.1121/1.4802904.

    Abstract

    Cross-language differences in the use of coarticulatory cues for the identification of fricatives have been demonstrated in a phoneme detection task: Listeners with perceptually similar fricative pairs in their native phoneme inventories (English, Polish, Spanish) relied more on cues from vowels than listeners with perceptually more distinct fricative contrasts (Dutch and German). The present gating study further investigated these cross-language differences and addressed three questions. (1) Are there cross-language differences in informativeness of parts of the speech signal regarding place of articulation for fricative identification? (2) Are such cross-language differences fricative-specific, or do they extend to the perception of place of articulation for plosives? (3) Is such language-specific uptake of information based on cues preceding or following the consonantal constriction? Dutch, Italian, Polish, and Spanish listeners identified fricatives and plosives in gated CV and VC syllables. The results showed cross-language differences in the informativeness of coarticulatory cues for fricative identification: Spanish and Polish listeners extracted place of articulation information from shorter portions of VC syllables. No language-specific differences were found for plosives, suggesting that greater reliance on coarticulatory cues did not generalize to other phoneme types. The language-specific differences for fricatives were based on coarticulatory cues into the consonant.
  • Walters, J., Rujescu, D., Franke, B., Giegling, I., Vasquez, A., Hargreaves, A., Russo, G., Morris, D., Hoogman, M., Da Costa, A., Moskvina, V., Fernandez, G., Gill, M., Corvin, A., O'Donovan, M., Donohoe, G., & Owen, M. (2013). The role of the major histocompatibility complex region in cognition and brain structure: A schizophrenia GWAS follow-up. American Journal of Psychiatry, 170, 877-885. doi:10.1176/appi.ajp.2013.12020226.

    Abstract

    Objective The authors investigated the effects of recently identified genome-wide significant schizophrenia genetic risk variants on cognition and brain structure. Method A panel of six single-nucleotide polymorphisms (SNPs) was selected to represent genome-wide significant loci from three recent genome-wide association studies (GWAS) for schizophrenia and was tested for association with cognitive measures in 346 patients with schizophrenia and 2,342 healthy comparison subjects. Nominally significant results were evaluated for replication in an independent case-control sample. For SNPs showing evidence of association with cognition, associations with brain structural volumes were investigated in a large independent healthy comparison sample. Results Five of the six SNPs showed no significant association with any cognitive measure. One marker in the major histocompatibility complex (MHC) region, rs6904071, showed independent, replicated evidence of association with delayed episodic memory and was significant when both samples were combined. In the combined sample of up to 3,100 individuals, this SNP was associated with widespread effects across cognitive domains, although these additional associations were no longer significant after adjusting for delayed episodic memory. In the large independent structural imaging sample, the same SNP was also associated with decreased hippocampal volume. Conclusions The authors identified a SNP in the MHC region that was associated with cognitive performance in patients with schizophrenia and healthy comparison subjects. This SNP, rs6904071, showed a replicated association with episodic memory and hippocampal volume. These findings implicate the MHC region in hippocampal structure and functioning, consistent with the role of MHC proteins in synaptic development and function. Follow-up of these results has the potential to provide insights into the pathophysiology of schizophrenia and cognition.

    Additional information

    Hoogman_2013_JourAmePsy.supp.pdf
  • Wang, L., Bastiaansen, M. C. M., Yang, Y., & Hagoort, P. (2013). ERP evidence on the interaction between information structure and emotional salience of words. Cognitive, Affective and Behavioral Neuroscience, 13, 297-310. doi:10.3758/s13415-012-0146-2.

    Abstract

    Both emotional words and words focused by information structure can capture attention. This study examined the interplay between emotional salience and information structure in modulating attentional resources in the service of integrating emotional words into sentence context. Event-related potentials (ERPs) to affectively negative, neutral, and positive words, which were either focused or nonfocused in question–answer pairs, were evaluated during sentence comprehension. The results revealed an early negative effect (90–200 ms), a P2 effect, as well as an effect in the N400 time window, for both emotional salience and information structure. Moreover, an interaction between emotional salience and information structure occurred within the N400 time window over right posterior electrodes, showing that information structure influences the semantic integration only for neutral words, but not for emotional words. This might reflect the fact that the linguistic salience of emotional words can override the effect of information structure on the integration of words into context. The interaction provides evidence for attention–emotion interactions at a later stage of processing. In addition, the absence of interaction in the early time window suggests that the processing of emotional information is highly automatic and independent of context. The results suggest independent attention capture systems of emotional salience and information structure at the early stage but an interaction between them at a later stage, during the semantic integration of words.
  • Wang, L., Zhu, Z., Bastiaansen, M. C. M., Hagoort, P., & Yang, Y. (2013). Recognizing the emotional valence of names: An ERP study. Brain and Language, 125, 118-127. doi:10.1016/j.bandl.2013.01.006.

    Abstract

    Unlike common nouns, person names refer to unique entities and generally have a referring function. We used event-related potentials to investigate the time course of identifying the emotional meaning of nouns and names. The emotional valence of names and nouns were manipulated separately. The results show early N1 effects in response to emotional valence only for nouns. This might reflect automatic attention directed towards emotional stimuli. The absence of such an effect for names supports the notion that the emotional meaning carried by names is accessed after word recognition and person identification. In addition, both names with negative valence and emotional nouns elicited late positive effects, which have been associated with evaluation of emotional significance. This positive effect started earlier for nouns than for names, but with similar durations. Our results suggest that distinct neural systems are involved in the retrieval of names’ and nouns’ emotional meaning.
  • Wang, L., & Chu, M. (2013). The role of beat gesture and pitch accent in semantic processing: An ERP study. Neuropsychologia, 51(13), 2847-2855. doi:10.1016/j.neuropsychologia.2013.09.027.

    Abstract

    The present study investigated whether and how beat gesture (small baton-like hand movements used to emphasize information in speech) influences semantic processing as well as its interaction with pitch accent during speech comprehension. Event-related potentials were recorded as participants watched videos of a person gesturing and speaking simultaneously. The critical words in the spoken sentences were accompanied by a beat gesture, a control hand movement, or no hand movement, and were expressed either with or without pitch accent. We found that both beat gesture and control hand movement induced smaller negativities in the N400 time window than when no hand movement was presented. The reduced N400s indicate that both beat gesture and control movement facilitated the semantic integration of the critical word into the sentence context. In addition, the words accompanied by beat gesture elicited smaller negativities in the N400 time window than those accompanied by control hand movement over right posterior electrodes, suggesting that beat gesture has a unique role for enhancing semantic processing during speech comprehension. Finally, no interaction was observed between beat gesture and pitch accent, indicating that they affect semantic processing independently.
  • Warmelink, L., Vrij, A., Mann, S., Leal, S., & Poletiek, F. H. (2013). The effects of unexpected questions on detecting familiar and unfamiliar lies. Psychiatry, Psychology and law, 20(1), 29-35. doi:10.1080/13218719.2011.619058.

    Abstract

    Previous research suggests that lie detection can be improved by asking the interviewee unexpected questions. The present experiment investigates the effect of two types of unexpected questions: background questions and detail questions, on detecting lies about topics with which the interviewee is (a) familiar or (b) unfamiliar. In this experiment, 66 participants read interviews in which interviewees answered background or detail questions, either truthfully or deceptively. Those who answered deceptively could be lying about a topic they were familiar with or about a topic they were unfamiliar with. The participants were asked to judge whether the interviewees were lying. The results revealed that background questions distinguished truths from both types of lies, while the detail questions distinguished truths from unfamiliar lies, but not from familiar lies. The implications of these findings are discussed.
  • Warner, N., Smits, R., McQueen, J. M., & Cutler, A. (2005). Phonological and statistical effects on timing of speech perception: Insights from a database of Dutch diphone perception. Speech Communication, 46(1), 53-72. doi:10.1016/j.specom.2005.01.003.

    Abstract

    We report detailed analyses of a very large database on timing of speech perception collected by Smits et al. (Smits, R., Warner, N., McQueen, J.M., Cutler, A., 2003. Unfolding of phonetic information over time: A database of Dutch diphone perception. J. Acoust. Soc. Am. 113, 563–574). Eighteen listeners heard all possible diphones of Dutch, gated in portions of varying size and presented without background noise. The present report analyzes listeners’ responses across gates in terms of phonological features (voicing, place, and manner for consonants; height, backness, and length for vowels). The resulting patterns for feature perception differ from patterns reported when speech is presented in noise. The data are also analyzed for effects of stress and of phonological context (neighboring vowel vs. consonant); effects of these factors are observed to be surprisingly limited. Finally, statistical effects, such as overall phoneme frequency and transitional probabilities, along with response biases, are examined; these too exercise only limited effects on response patterns. The results suggest highly accurate speech perception on the basis of acoustic information alone.
  • Warner, N., Kim, J., Davis, C., & Cutler, A. (2005). Use of complex phonological patterns in speech processing: Evidence from Korean. Journal of Linguistics, 41(2), 353-387. doi:10.1017/S0022226705003294.

    Abstract

    Korean has a very complex phonology, with many interacting alternations. In a coronal-/i/ sequence, depending on the type of phonological boundary present, alternations such as palatalization, nasal insertion, nasal assimilation, coda neutralization, and intervocalic voicing can apply. This paper investigates how the phonological patterns of Korean affect processing of morphemes and words. Past research on languages such as English, German, Dutch, and Finnish has shown that listeners exploit syllable structure constraints in processing speech and segmenting it into words. The current study shows that in parsing speech, listeners also use much more complex patterns that relate the surface phonological string to various boundaries.
  • Wassenaar, M., & Hagoort, P. (2005). Word-category violations in patients with Broca's aphasia: An ERP study. Brain and Language, 92, 117-137. doi:10.1016/j.bandl.2004.05.011.

    Abstract

    An event-related brain potential experiment was carried out to investigate on-line syntactic processing in patients with Broca’s aphasia. Subjects were visually presented with sentences that were either syntactically correct or contained violations of word-category. Three groups of subjects were tested: Broca patients (N=11), non-aphasic patients with a right hemisphere (RH) lesion (N=9), and healthy aged-matched controls (N=15). Both control groups appeared sensitive to the violations of word-category as shown by clear P600/SPS effects. The Broca patients displayed only a very reduced and delayed P600/SPS effect. The results are discussed in the context of a lexicalist parsing model. It is concluded that Broca patients are hindered to detect on-line violations of word-category, if word class information is incomplete or delayed available.
  • Wegener, C. (2005). Major word classes in Savosavo. Grazer Linguistische Studien, 64, 29-52.
  • Wheeldon, L. R., & Levelt, W. J. M. (1995). Monitoring the time course of phonological encoding. Journal of Memory and Language, 34(3), 311-334. doi:10.1006/jmla.1995.1014.

    Abstract

    Three experiments examined the time course of phonological encoding in speech production. A new methodology is introduced in which subjects are required to monitor their internal speech production for prespecified target segments and syllables. Experiment 1 demonstrated that word initial target segments are monitored significantly faster than second syllable initial target segments. The addition of a concurrent articulation task (Experiment 1b) had a limited effect on performance, excluding the possibility that subjects are monitoring a subvocal articulation of the carrier word. Moreover, no relationship was observed between the pattern of monitoring latencies and the timing of the targets in subjects′ overt speech. Subjects are not, therefore, monitoring an internal phonetic representation of the carrier word. Experiment 2 used the production monitoring task to replicate the syllable monitoring effect observed in speech perception experiments: responses to targets were faster when they corresponded to the initial syllable of the carrier word than when they did not. We conclude that subjects are monitoring their internal generation of a syllabified phonological representation. Experiment 3 provides more detailed evidence concerning the time course of the generation of this representation by comparing monitoring latencies to targets within, as well as between, syllables. Some amendments to current models of phonological encoding are suggested in light of these results.
  • Whitmarsh, S., Udden, J., Barendregt, H., & Petersson, K. M. (2013). Mindfulness reduces habitual responding based on implicit knowledge: Evidence from artificial grammar learning. Consciousness and Cognition, (3), 833-845. doi:10.1016/j.concog.2013.05.007.

    Abstract

    Participants were unknowingly exposed to complex regularities in a working memory task. The existence of implicit knowledge was subsequently inferred from a preference for stimuli with similar grammatical regularities. Several affective traits have been shown to influence
    AGL performance positively, many of which are related to a tendency for automatic responding. We therefore tested whether the mindfulness trait predicted a reduction of grammatically congruent preferences, and used emotional primes to explore the influence of affect. Mindfulness was shown to correlate negatively with grammatically congruent responses. Negative primes were shown to result in faster and more negative evaluations.
    We conclude that grammatically congruent preference ratings rely on habitual responses, and that our findings provide empirical evidence for the non-reactive disposition of the mindfulness trait.
  • Wilkins, D. P., & Hill, D. (1995). When "go" means "come": Questioning the basicness of basic motion verbs. Cognitive Linguistics, 6, 209-260. doi:10.1515/cogl.1995.6.2-3.209.

    Abstract

    The purpose of this paper is to question some of the basic assumpiions concerning motion verbs. In particular, it examines the assumption that "come" and "go" are lexical universals which manifest a universal deictic Opposition. Against the background offive working hypotheses about the nature of'come" and ''go", this study presents a comparative investigation of t wo unrelated languages—Mparntwe Arrernte (Pama-Nyungan, Australian) and Longgu (Oceanic, Austronesian). Although the pragmatic and deictic "suppositional" complexity of"come" and "go" expressions has long been recognized, we argue that in any given language the analysis of these expressions is much more semantically and systemically complex than has been assumed in the literature. Languages vary at the lexical semantic level äs t o what is entailed by these expressions, äs well äs differing äs t o what constitutes the prototype and categorial structure for such expressions. The data also strongly suggest that, ifthere is a lexical universal "go", then this cannof be an inherently deictic expression. However, due to systemic Opposition with "come", non-deictic "go" expressions often take on a deictic Interpretation through pragmatic attribution. Thus, this crosslinguistic investigation of "come" and "go" highlights the need to consider semantics and pragmatics äs modularly separate.
  • Willems, R. M. (2013). Can literary studies contribute to cognitive neuroscience? Journal of literary semantics, 42(2), 217-222. doi:10.1515/jls-2013-0011.
  • Witteman, M. J., Weber, A., & McQueen, J. M. (2013). Foreign accent strength and listener familiarity with an accent co-determine speed of perceptual adaptation. Attention, Perception & Psychophysics, 75, 537-556. doi:10.3758/s13414-012-0404-y.

    Abstract

    We investigated how the strength of a foreign accent and varying types of experience with foreign-accented speech influence the recognition of accented words. In Experiment 1, native Dutch listeners with limited or extensive prior experience with German-accented Dutch completed a cross-modal priming experiment with strongly, medium, and weakly accented words. Participants with limited experience were primed by the medium and weakly accented words, but not by the strongly accented words. Participants with extensive experience were primed by all accent types. In Experiments 2 and 3, Dutch listeners with limited experience listened to a short story before doing the cross-modal priming task. In Experiment 2, the story was spoken by the priming task speaker and either contained strongly accented words or did not. Strongly accented exposure led to immediate priming by novel strongly accented words, while exposure to the speaker without strongly accented tokens led to priming only in the experiment’s second half. In Experiment 3, listeners listened to the story with strongly accented words spoken by a different German-accented speaker. Listeners were primed by the strongly accented words, but again only in the experiment’s second half. Together, these results show that adaptation to foreign-accented speech is rapid but depends on accent strength and on listener familiarity with those strongly accented words.
  • Wittenburg, P., Skiba, R., & Trilsbeek, P. (2005). The language archive at the MPI: Contents, tools, and technologies. Language Archives Newsletter, 5, 7-9.
  • Wright, S. E., & Windhouwer, M. (2013). ISOcat - im Reich der Datenkategorien. eDITion: Fachzeitschrift für Terminologie, 9(1), 8-12.

    Abstract

    Im ISOcat-Datenkategorie-Register (Data Category Registry, www.isocat.org) des Technischen Komitees ISO/TC 37 (Terminology and other language and content resources) werden Feldnamen und Werte für Sprachressourcen beschrieben. Empfohlene Feldnamen und zuverlässige Definitionen sollen dazu beitragen, dass Sprachdaten unabhängig von Anwendungen, Plattformen und Communities of Practice (CoP) wiederverwendet werden können. Datenkategorie-Gruppen (Data Category Selections) können eingesehen, ausgedruckt, exportiert und nach kostenloser Registrierung auch neu erstellt werden.
  • Zeshan, U., Escobedo Delgado, C. E., Dikyuva, H., Panda, S., & De Vos, C. (2013). Cardinal numerals in rural sign languages: Approaching cross-modal typology. Linguistic Typology, 17(3), 357-396. doi:10.1515/lity-2013-0019.

    Abstract

    This article presents data on cardinal numerals in three sign languages from small-scale communities with hereditary deafness. The unusual features found in these data considerably extend the known range of typological variety across sign languages. Some features, such as non-decimal numeral bases, are unattested in sign languages, but familiar from spoken languages, while others, such as subtractive sub-systems, are rare in sign and speech. We conclude that for a complete typological appraisal of a domain, an approach to cross-modal typology, which includes a typologically diverse range of sign languages in addition to spoken languages, is both instructive and feasible.
  • Zeshan, U., Vasishta, M. N., & Sethna, M. (2005). Implementation of Indian Sign Language in educational settings. Asia Pacific Disability Rehabilitation Journal, 16(1), 16-40.

    Abstract

    This article reports on several sub-projects of research and development related to the use of Indian Sign Language in educational settings. In many countries around the world, sign languages are now recognised as the legitimate, full-fledged languages of the deaf communities that use them. In India, the development of sign language resources and their application in educational contexts, is still in its initial stages. The work reported on here, is the first principled and comprehensive effort of establishing educational programmes in Indian Sign Language at a national level. Programmes are of several types: a) Indian Sign Language instruction for hearing people; b) sign language teacher training programmes for deaf people; and c) educational materials for use in schools for the Deaf. The conceptual approach used in the programmes for deaf students is known as bilingual education, which emphasises the acquisition of a first language, Indian Sign Language, alongside the acquisition of spoken languages, primarily in their written form.
  • Zhang, J., Bao, S., Furumai, R., Kucera, K. S., Ali, A., Dean, N. M., & Wang, X.-F. (2005). Protein phosphatase 5 is required for ATR-mediated checkpoint activation. Molecular and Cellular Biology, 25, 9910-9919. doi:10.1128/​MCB.25.22.9910-9919.2005.

    Abstract

    In response to DNA damage or replication stress, the protein kinase ATR is activated and subsequently transduces genotoxic signals to cell cycle control and DNA repair machinery through phosphorylation of a number of downstream substrates. Very little is known about the molecular mechanism by which ATR is activated in response to genotoxic insults. In this report, we demonstrate that protein phosphatase 5 (PP5) is required for the ATR-mediated checkpoint activation. PP5 forms a complex with ATR in a genotoxic stress-inducible manner. Interference with the expression or the activity of PP5 leads to impairment of the ATR-mediated phosphorylation of hRad17 and Chk1 after UV or hydroxyurea treatment. Similar results are obtained in ATM-deficient cells, suggesting that the observed defect in checkpoint signaling is the consequence of impaired functional interaction between ATR and PP5. In cells exposed to UV irradiation, PP5 is required to elicit an appropriate S-phase checkpoint response. In addition, loss of PP5 leads to premature mitosis after hydroxyurea treatment. Interestingly, reduced PP5 activity exerts differential effects on the formation of intranuclear foci by ATR and replication protein A, implicating a functional role for PP5 in a specific stage of the checkpoint signaling pathway. Taken together, our results suggest that PP5 plays a critical role in the ATR-mediated checkpoint activation.
  • De Zubicaray, G. I., Acheson, D. J., & Hartsuiker, R. J. (Eds.). (2013). Mind what you say - general and specific mechanisms for monitoring in speech production [Research topic] [Special Issue]. Frontiers in Human Neuroscience. Retrieved from http://www.frontiersin.org/human_neuroscience/researchtopics/mind_what_you_say_-_general_an/1197.

    Abstract

    Psycholinguistic research has typically portrayed speech production as a relatively automatic process. This is because when errors are made, they occur as seldom as one in every thousand words we utter. However, it has long been recognised that we need some form of control over what we are currently saying and what we plan to say. This capacity to both monitor our inner speech and self-correct our speech output has often been assumed to be a property of the language comprehension system. More recently, it has been demonstrated that speech production benefits from interfacing with more general cognitive processes such as selective attention, short-term memory (STM) and online response monitoring to resolve potential conflict and successfully produce the output of a verbal plan. The conditions and levels of representation according to which these more general planning, monitoring and control processes are engaged during speech production remain poorly understood. Moreover, there remains a paucity of information about their neural substrates, despite some of the first evidence of more general monitoring having come from electrophysiological studies of error related negativities (ERNs). While aphasic speech errors continue to be a rich source of information, there has been comparatively little research focus on instances of speech repair. The purpose of this Frontiers Research Topic is to provide a forum for researchers to contribute investigations employing behavioural, neuropsychological, electrophysiological, neuroimaging and virtual lesioning techniques. In addition, while the focus of the research topic is on novel findings, we welcome submission of computational simulations, review articles and methods papers.

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