Publications

Abstract

The Violation-of-Expectation paradigm is a widespread paradigm in infancy research that relies on looking time as an index of surprise. This methodological review aims to increase the reliability of future VoE studies by proposing to standardize reporting practices in this literature. I review 15 VoE studies on false-belief reasoning, which used a variety of experimental parameters. An analysis of the distribution of p-values across experiments suggests an absence of p-hacking. However, there are potential concerns with the accuracy of their measures of infants’ attention, as well as with the lack of a consensus on the parameters that should be used to set up VoE studies. I propose that (i) future VoE studies ought to report not only looking times (as a measure of attention) but also looking-away times (as an equally important measure of distraction); (ii) VoE studies must offer theoretical justification for the parameters they use, and (iii) when parameters are selected through piloting, pilot data must be reported in order to understand how parameters were selected. Future VoE studies ought to maximize the accuracy of their measures of infants’ attention since the reliability of their results and the validity of their conclusions both depend on the accuracy of their measures.

Abstract

There is an ongoing debate, both in philosophy and psychology, as to whether people are able to automatically infer what others may know, or whether they can only derive belief inferences by deploying cognitive resources. Evidence from laboratory tasks, often involving false beliefs or visual-perspective taking, has suggested that belief inferences are cognitively costly, controlled processes. Here we suggest that in everyday conversation, belief reasoning is pervasive and therefore potentially automatic in some cases. To test this hypothesis, we conducted two pre-registered self-paced reading experiments (N1 = 91, N2 = 89). The results of these experiments showed that participants slowed down when a stranger commented ‘That greasy food is bad for your ulcer’ relative to conditions where a stranger commented on their own ulcer or a friend made either comment – none of which violated participants’ common-ground expectations. We conclude that Theory of Mind models need to account for belief reasoning in conversation as it is at the center of everyday social interaction

Abstract

A pragmatic account of referential communication is developed which presents an alternative to traditional Gricean accounts by focusing on cooperativeness and efficiency, rather than informativity. The results of four language-production experiments support the view that speakers can be cooperative when producing redundant adjectives, doing so more often when color modification could facilitate the listener's search for the referent in the visual display (Experiment 1a). By contrast, when the listener knew which shape was the target, speakers did not produce redundant color adjectives (Experiment 1b). English speakers used redundant color adjectives more often than Spanish speakers, suggesting that speakers are sensitive to the differential efficiency of prenominal and postnominal modification (Experiment 2). Speakers were also cooperative when using redundant size adjectives (Experiment 3). Overall, these results show how discriminability affects a speaker's choice of referential expression above and beyond considerations of informativity, supporting the view that redundant speakers can be cooperative.

Abstract

The nature of phonological representations has been extensively studied in phonology and psycholinguistics. While full specification is still the norm in psycholinguistic research, underspecified representations may better account for perceptual asymmetries. In this paper, we report on a mismatch negativity (MMN) study with Dutch listeners who took part in a passive oddball paradigm to investigate when the brain notices the difference between expected and observed vowels. In particular, we tested neural discrimination (indicating perceptual discrimination) of the tense mid vowel pairs /o/-/ø/ (place contrast), /e/-/ø/ (labiality or rounding contrast), and /e/-/o/ (place and labiality contrast). Our results show (a) a perceptual asymmetry for place in the /o/-/ø/ contrast, supporting underspecification of [CORONAL] and replicating earlier results for German, and (b) a perceptual asymmetry for labiality for the /e/-/ø/ contrast, which was not reported in the German study. A labial deviant [ø] (standard /e/) yielded a larger MMN than a deviant [e] (standard /ø/). No asymmetry was found for the two-feature contrast. This study partly replicates a similar MMN study on German vowels, and partly presents new findings indicating cross-linguistic differences. Although the vowel inventory of Dutch and German is to a large extent comparable, their (morpho)phonological systems are different, which is reflected in processing.

Abstract

Pervading global narratives suggest that political polarization is increasing, yet the accuracy of such group meta-perceptions has been drawn into question. A recent US study suggests that these beliefs are inaccurate and drive polarized beliefs about out-groups. However, it also found that informing people of inaccuracies reduces those negative beliefs. In this work, we explore whether these results generalize to other countries. To achieve this, we replicate two of the original experiments with 10,207 participants across 26 countries. We focus on local group divisions, which we refer to as fault lines. We find broad generalizability for both inaccurate meta-perceptions and reduced negative motive attribution through a simple disclosure intervention. We conclude that inaccurate and negative group meta-perceptions are exhibited in myriad contexts and that informing individuals of their misperceptions can yield positive benefits for intergroup relations. Such generalizability highlights a robust phenomenon with implications for political discourse worldwide.

Abstract

In this article, we present the spatial logistics task (SLOT) platform for investigating multimodal communication between 2 human participants. Presented are the SLOT communication task and the software and hardware that has been developed to run SLOT experiments and record the participants’ multimodal behavior. SLOT offers a high level of flexibility in varying the context of the communication and is particularly useful in studies of the relationship between pen gestures and speech. We illustrate the use of the SLOT platform by discussing the results of some early experiments. The first is an experiment on negotiation with a one-way mirror between the participants, and the second is an exploratory study of automatic recognition of spontaneous pen gestures. The results of these studies demonstrate the usefulness of the SLOT platform for conducting multimodal communication research in both human– human and human–computer interactions.

Abstract

We analysed both structural and functional aspects of sentences containing the four
adverbials “after”, “before”, “because”, and “if” in two dense corpora of parent-child
interactions from two British English-acquiring children (2;00–4;07). In comparing
mothers’ and children’s usage we separate out the effects of frequency, cognitive
complexity and pragmatics in explaining the course of acquisition of adverbial
sentences. We also compare these usage patterns to stimuli used in a range of
experimental studies and show how differences may account for some of the difficulties
that children have shown in experiments. In addition, we report descriptive data on
various aspects of adverbial sentences that have not yet been studied as a resource for
future investigations.

Abstract

We study how people attend to and memorize endings of events that differ in the degree to which objects in them are affected by an action: Resultative events show objects that undergo a visually salient change in state during the course of the event (peeling a potato), and non‐resultative events involve objects that undergo no, or only partial state change (stirring in a pan). We investigate general cognitive principles, and potential language‐specific influences, in verbal and nonverbal event encoding and memory, across two experiments with Dutch and Estonian participants. Estonian marks a viewer's perspective on an event's result obligatorily via grammatical case on direct object nouns: Objects undergoing a partial/full change in state in an event are marked with partitive/accusative case, respectively. Therefore, we hypothesized increased saliency of object states and event results in Estonian speakers, as compared to speakers of Dutch. Findings show (a) a general cognitive principle of attending carefully to endings of resultative events, implying cognitive saliency of object states in event processing; (b) a language‐specific boost on attention and memory of event results under verbal task demands in Estonian speakers. Results are discussed in relation to theories of event cognition, linguistic relativity, and thinking for speaking.

Abstract

Participants' eye movements were monitored as they heard sentences and saw four pictured objects on a computer screen. Participants were instructed to click on the object mentioned in the sentence. There were more transitory fixations to pictures representing monosyllabic words (e.g. ham) when the first syllable of the target word (e.g. hamster) had been replaced by a recording of the monosyllabic word than when it came from a different recording of the target word. This demonstrates that a phonemically identical sequence can contain cues that modulate its lexical interpretation. This effect was governed by the duration of the sequence, rather than by its origin (i.e. which type of word it came from). The longer the sequence, the more monosyllabic-word interpretations it generated. We argue that cues to lexical-embedding disambiguation, such as segmental lengthening, result from the realization of a prosodic boundary that often but not always follows monosyllabic words, and that lexical candidates whose word boundaries are aligned with prosodic boundaries are favored in the word-recognition process.

Abstract

In recent years, it has become clear that attention plays an important role in spoken word production. Some of this evidence comes from distributional analyses of reaction time (RT) in regular picture naming and picture-word interference. Yet we lack a mechanistic account of how the properties of RT distributions come to reflect attentional processes and how these processes may in turn modulate the amount of conflict between lexical representations. Here, we present a computational account according to which attentional lapses allow for existing conflict to build up unsupervised on a subset of trials, thus modulating the shape of the resulting RT distribution. Our process model resolves discrepancies between outcomes of previous studies on semantic interference. Moreover, the model's predictions were confirmed in a new experiment where participants' motivation to remain attentive determined the size and distributional locus of semantic interference in picture naming. We conclude that process modeling of RT distributions importantly improves our understanding of the interplay between attention and conflict in word production. Our model thus provides a framework for interpreting distributional analyses of RT data in picture naming tasks.

Abstract

Memory is fundamental for comprehending and segmenting the flow of activity around us into units called “events”. Here, we investigate the effect of the movement dynamics of actions (ceased, ongoing) and the inner structure of events (with or without object-state change) on people's event memory. Furthermore, we investigate how describing events, and the meaning and form of verb predicates used (denoting a culmination moment, or not, in single verbs or verb-satellite constructions), affects event memory. Before taking a surprise recognition task, Spanish and Mandarin speakers (who lexicalise culmination in different verb predicate forms) watched short videos of events, either in a non-verbal (probe-recognition) or a verbal experiment (event description). Results show that culminated events (i.e. ceased change-of-state events) were remembered best across experiments. Language use showed to enhance memory overall. Further, the form of the verb predicates used for denoting culmination had a moderate effect on memory.

Abstract

Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.

Abstract

Human experience and communication are centred on events, and event apprehension is a rapid process that draws on the visual perception and immediate categorization of event roles (“who does what to whom”). We demonstrate a role for syntactic structure in visual information uptake for event apprehension. An event structure foregrounding either the agent or patient was activated during speaking, transiently modulating the apprehension of subsequently viewed unrelated events. Speakers of Dutch described pictures with actives and passives (agent and patient foregrounding, respectively). First fixations on pictures of unrelated events that were briefly presented (for 300 ms) next were influenced by the active or passive structure of the previously produced sentence. Going beyond the study of how single words cue object perception, we show that sentence structure guides the viewpoint taken during rapid event apprehension.

Abstract

The epigenetic enzyme p300/CBP-associated factor (PCAF) belongs to the GCN5-related N-acetyltransferase (GNAT) family together with GCN5. Although its transcriptional and post-translational function is well characterized, little is known about its properties as regulator of cell metabolism. Here, we report the mitochondrial localization of PCAF conferred by an 85 aa mitochondrial targeting sequence (MTS) at the N-terminal region of the protein. In mitochondria, one of the PCAF targets is the isocitrate dehydrogenase 2 (IDH2) acetylated at lysine 180. This PCAF-regulated post-translational modification might reduce IDH2 affinity for isocitrate as a result of a conformational shift involving predictively the tyrosine at position 179. Site-directed mutagenesis and functional studies indicate that PCAF regulates IDH2, acting at dual level during myoblast differentiation: at a transcriptional level together with MyoD, and at a post-translational level by direct modification of lysine acetylation in mitochondria. The latter event determines a decrease in IDH2 function with negative consequences on muscle fiber formation in C2C12 cells. Indeed, a MTS-deprived PCAF does not localize into mitochondria, remains enriched into the nucleus, and contributes to a significant increase of muscle-specific gene expression enhancing muscle differentiation. The role of PCAF in mitochondria is a novel finding shedding light on metabolic processes relevant to early muscle precursor differentiation.—Savoia, M., Cencioni, C., Mori, M., Atlante, S., Zaccagnini, G., Devanna, P., Di Marcotullio, L., Botta, B., Martelli, F., Zeiher, A. M., Pontecorvi, A., Farsetti, A., Spallotta, F., Gaetano, C. P300/CBP-associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation.

Abstract

Background

Heterozygous variants in CNTNAP2 have been implicated in a wide range of neurological phenotypes, including intellectual disability (ID), epilepsy, autistic spectrum disorder (ASD), and impaired language. However, heterozygous variants can also be found in unaffected individuals. Biallelic CNTNAP2 variants are rarer and cause a well-defined genetic syndrome known as CASPR2 deficiency disorder, a condition characterised by ID, early-onset refractory epilepsy, language impairment, and autistic features.
Case-report

A 7-year-old boy presented with hyperkinetic stereotyped movements that started during early infancy and persisted over childhood. Abnormal movements consisted of rhythmic and repetitive shaking of the four limbs, with evident stereotypic features. Additional clinical features included ID, attention deficit-hyperactivity disorder (ADHD), ASD, and speech impairment, consistent with CASPR2 deficiency disorder. Whole-genome array comparative genomic hybridization detected a maternally inherited 0.402 Mb duplication, which involved intron 1, exon 2, and intron 2 of CNTNAP2 (c.97 +?_209-?dup). The affected region in intron 1 contains a binding site for the transcription factor FOXP2, potentially leading to abnormal CNTNAP2 expression regulation. Sanger sequencing of the coding region of CNTNAP2 also identified a paternally-inherited missense variant c.2752C > T, p.(Leu918Phe).
Conclusion

This case expands the molecular and phenotypic spectrum of CASPR2 deficiency disorder, suggesting that Hyperkinetic stereotyped movements may be a rare, yet significant, clinical feature of this complex neurological disorder. Furthermore, the identification of an in-frame, largely non-coding duplication in CNTNAP2 points to a sophisticated underlying molecular mechanism, likely involving impaired FOXP2 binding.

Abstract

This letter evaluates potential benefits of combining human speech recognition ~HSR! and automatic speech recognition by building a joint model of an automatic phone recognizer ~APR! and a computational model of HSR, viz., Shortlist @Norris, Cognition 52, 189–234 ~1994!#. Experiments based on ‘‘real-life’’ speech highlight critical limitations posed by some of the simplifying assumptions made in models of human speech recognition. These limitations could be overcome by avoiding hard phone decisions at the output side of the APR, and by using a match between the input and the internal lexicon that flexibly copes with deviations from canonical phonemic representations.

Abstract

In this paper, we present an automatic speech recognition (ASR) system based on the combination of an automatic phone recogniser and a computational model of human speech recognition – SpeM – that is capable of computing ‘word activations’ during the recognition process, in addition to doing normal speech recognition, a task in which conventional ASR architectures only provide output after the end of an utterance. We explain the notion of word activation and show that it can be used for ‘early recognition’, i.e. recognising a word before the end of the word is available. Our ASR system was tested on 992 continuous speech utterances, each containing at least one target word: a city name of at least two syllables. The results show that early recognition was obtained for 72.8% of the target words that were recognised correctly. Also, it is shown that word activation can be used as an effective confidence measure.

Abstract

We have recently developed a new model of human speech recognition, based on automatic speech recognition techniques [1]. The present paper has two goals. First, we show that the new model performs well in the recognition of lexically ambiguous input. These demonstrations suggest that the model is able to operate in the same optimal way as human listeners. Second, we discuss how to relate the behaviour of a recogniser, designed to discover the optimum path through a word lattice, to data from human listening experiments. We argue that this requires a metric that combines both path-based and word-based measures of recognition performance. The combined metric varies continuously as the input speech signal unfolds over time.

Abstract

In this paper, we present a novel computational model of human speech recognition – called SpeM – based on the theory underlying Shortlist. We will show that SpeM, in combination with an automatic phone recogniser (APR), is able to simulate the human speech recognition process from the acoustic signal to the ultimate recognition of words. This joint model takes an acoustic speech file as input and calculates the activation flows of candidate words on the basis of the degree of fit of the candidate words with the input. Experiments showed that SpeM outperforms Shortlist on the recognition of ‘real-life’ input. Furthermore, SpeM performs only slightly worse than an off-the-shelf full-blown automatic speech recogniser in which all words are equally probable, while it provides a transparent computationally elegant paradigm for modelling word activations in human word recognition.

Abstract

Exposure to traumatic stress increases the odds of developing a broad range of psychiatric conditions. Genetic studies targeting multiple stress-related quantitative phenotypes may shed light on mechanisms underlying vulnerability to psychopathology in the aftermath of stressful events. We applied a multivariate genome-wide association study (GWAS) to a unique military cohort (N = 583) in which we measured biochemical and behavioral phenotypes. The availability of pre- and post-deployment measurements allowed to capture changes in these phenotypes in response to stress. For genome-wide significant loci, we performed functional annotation, phenome-wide analysis and quasi-replication in PTSD case-control GWASs. We discovered one genetic variant reaching genome-wide significant association, surviving permutation and sensitivity analyses (rs10100651, p = 9.9 × 10−9). Functional annotation prioritized the genes INTS8 and TP53INP1. A phenome-wide scan revealed a significant association of these same genes with sleeping problems, hypertension and subjective well-being. Finally, a targeted lookup revealed nominally significant association of rs10100651 in a PTSD case-control GWAS in the UK Biobank (p = 0.02). We provide comprehensive evidence from multiple resources hinting at a role of the highlighted genetic variant in the human stress response, marking the power of multivariate genome-wide analysis of quantitative measures in stress research. Future genetic and functional studies can target this locus to further assess its effects on stress mediation and its possible role in psychopathology or resilience.

Abstract

The evaluation of transcranial magnetic stimulation (TMS)-induced motor evoked potentials (MEPs) promises valuable information about fundamental brain related mechanisms and may serve as a diagnostic tool for clinical monitoring of therapeutic progress or surgery procedures. However, reports about spontaneous fluctuations of MEP amplitudes causing high intra-individual variability have led to increased concerns about the reliability of this measure. One possible cause for high variability of MEPs could be neuronal oscillatory activity, which reflects fluctuations of membrane potentials that systematically increase and decrease the excitability of neuronal networks. Here, we investigate the dependence of MEP amplitude on oscillation power and phase by combining the application of single pulse TMS over the primary motor cortex with concurrent recordings of electromyography and electroencephalography. Our results show that MEP amplitude is correlated to alpha phase, alpha power as well as beta phase. These findings may help explain corticospinal excitability fluctuations by highlighting the modulatory effect of alpha and beta phase on MEPs. In the future, controlling for such a causal relationship may allow for the development of new protocols, improve this method as a (diagnostic) tool and increase the specificity and efficacy of general TMS applications.

Abstract

During language production and comprehension, information about a word's syntactic properties is sometimes needed. While the decision about the grammatical gender of a word requires access to syntactic knowledge, it has also been hypothesized that semantic (i.e., biological gender) or phonological information (i.e., sound regularities) may influence this decision. Event-related potentials (ERPs) were measured while native speakers of German processed written words that were or were not semantically and/or phonologically marked for gender. Behavioral and ERP results showed that participants were faster in making a gender decision when words were semantically and/or phonologically gender marked than when this was not the case, although the phonological effects were less clear. In conclusion, our data provide evidence that even though participants performed a grammatical gender decision, this task can be influenced by semantic and phonological factors.

Abstract

This study investigated the time course of phonological encoding during speech production planning. Previous research has shown that conceptual/semantic information precedes syntactic information in the planning of speech production and that syntactic information is available earlier than phonological information. Here, we studied the relative time courses of the two different processes within phonological encoding, i.e. metrical encoding and syllabification. According to one prominent theory of language production, metrical encoding involves the retrieval of the stress pattern of a word, while syllabification is carried out to construct the syllabic structure of a word. However, the relative timing of these two processes is underspecified in the theory. We employed an implicit picture naming task and recorded event-related brain potentials to obtain fine-grained temporal information about metrical encoding and syllabification. Results revealed that both tasks generated effects that fall within the time window of phonological encoding. However, there was no timing difference between the two effects, suggesting that they occur approximately at the same time.

Abstract

In this study, we investigated grammatical feature selection during noun phrase production in German and Dutch. More specifically, we studied the conditions under which different grammatical genders select either the same or different determiners or suffixes. Pictures of one or two objects paired with a gender-congruent or a gender-incongruent distractor word were presented. Participants named the pictures using a singular or plural noun phrase with the appropriate determiner and/or adjective in German or Dutch. Significant effects of gender congruency were only obtained in the singular condition where the selection of determiners is governed by the target’s gender, but not in the plural condition where the determiner is identical for all genders. When different suffixes were to be selected in the gender-incongruent condition, no gender congruency effect was obtained. The results suggest that the so-called gender congruency effect is really a determiner congruency effect. The overall pattern of results is interpreted as indicating that grammatical feature selection is an automatic consequence of lexical node selection and therefore not subject to interference from other grammatical features. This implies that lexical node and grammatical feature selection operate with distinct principles.

Abstract

This study investigated the encoding of metrical information during speech production in Dutch. In Experiment 1, participants were asked to judge whether bisyllabic picture names had initial or final stress. Results showed significantly faster decision times for initially stressed targets (e.g., LEpel 'spoon') than for targets with final stress (e.g., liBEL 'dragon fly'; capital letters indicate stressed syllables) and revealed that the monitoring latencies are not a function of the picture naming or object recognition latencies to the same pictures. Experiments 2 and 3 replicated the outcome of the first experiment with bi- and trisyllabic picture names. These results demonstrate that metrical information of words is encoded rightward incrementally during phonological encoding in speech production. The results of these experiments are in line with Levelt's model of phonological encoding.

Abstract

A series of experiments was carried out to investigate the syllable affiliation of intervocalic consonants following short vowels, long vowels, and schwa in Dutch. Special interest was paid to words such as letter ['leter] ''id.,'' where a short vowel is followed by a single consonant. On phonological grounds one may predict that the first syllable should always be closed, but earlier psycholinguistic research had shown that speakers tend to leave these syllables open. In our experiments, bisyllabic word forms were presented aurally, and participants produced their syllables in reversed order (Experiments 1 through 5), or repeated the words inserting a pause between the syllables (Experiment 6). The results showed that participants generally closed syllables with a short vowel. However, in a significant number of the cases they produced open short vowel syllables. Syllables containing schwa, like syllables with a long vowel, were hardly ever closed. Word stress, the phonetic quality of the vowel in the first syllable, and the experimental context influenced syllabification. Taken together, the experiments show that native speakers syllabify bisyllabic Dutch nouns in accordance with a small set of prosodic output constraints. To account for the variability of the results, we propose that these constraints differ in their probabilities of being applied.

Abstract

This paper addresses the role of the adverb in Dutch direct object scrambling constructions. We report four experiments in which we investigate whether the structural position and the scope sensitivity of the adverb affect acceptability judgments of scrambling constructions and native speakers' tendency to scramble definite objects. We conclude that the type of adverb plays a key role in Dutch word ordering preferences.

Abstract

In certain varieties of Dutch spoken among young people, the preposition and determiner in locative and directional PPs can sometimes be omitted. We argue on the basis of language data taken from Twitter and intuitions of young speakers of Dutch that nominal arguments in these constructions do not have a DP layer, the absence of which leads to a special interpretation. The option to omit the preposition is related to the structural and semantic complexity of the verb. The bare construction is possible only with simple verbs, and not with manner-of-motion verbs. We present an analysis that accounts for the non-pronunciation of prepositions in directional predicates by claiming that they can be licensed through incorporation into the verb. This type of incorporation is blocked if the verb is structurally complex.

Abstract

This dataset, colloquially known as the Mother Of Unification Studies (MOUS) dataset, contains multimodal neuroimaging data that has been acquired from 204 healthy human subjects. The neuroimaging protocol consisted of magnetic resonance imaging (MRI) to derive information at high spatial resolution about brain anatomy and structural connections, and functional data during task, and at rest. In addition, magnetoencephalography (MEG) was used to obtain high temporal resolution electrophysiological measurements during task, and at rest. All subjects performed a language task, during which they processed linguistic utterances that either consisted of normal or scrambled sentences. Half of the subjects were reading the stimuli, the other half listened to the stimuli. The resting state measurements consisted of 5 minutes eyes-open for the MEG and 7 minutes eyes-closed for fMRI. The neuroimaging data, as well as the information about the experimental events are shared according to the Brain Imaging Data Structure (BIDS) format. This unprecedented neuroimaging language data collection allows for the investigation of various aspects of the neurobiological correlates of language.

Abstract

Speakers are influenced by the linguistic context: hearing one syntactic alternative leads to an increased chance that the speaker will repeat this structure in the subsequent utterance (i.e., syntactic priming, or structural persistence). Top-down influences, such as whether a conversation partner (or, interlocutor) is present, may modulate the degree to which syntactic priming occurs. In the current study, we indeed show that the magnitude of syntactic alignment increases when speakers are interacting with an interlocutor as opposed to doing the experiment alone. The structural persistence effect for passive sentences is stronger in the presence of an interlocutor than when no interlocutor is present (i.e., when the participant is primed by a recording). We did not find evidence, however, that a speaker’s syntactic priming magnitude is influenced by the degree of their conversation partner’s priming magnitude. Together, these results support a mediated account of syntactic priming, in which syntactic choices are not only affected by preceding linguistic input, but also by top-down influences, such as the speakers’ communicative intent.

Abstract

When comprehending speech-in-noise (SiN), younger and older adults benefit from seeing the speaker’s mouth, i.e. visible speech. Younger adults additionally benefit from manual iconic co-speech gestures. Here, we investigate to what extent younger and older adults benefit from perceiving both visual articulators while comprehending SiN, and whether this is modulated by working memory and inhibitory control. Twenty-eight younger and 28 older adults performed a word recognition task in three visual contexts: mouth blurred (speech-only), visible speech, or visible speech + iconic gesture. The speech signal was either clear or embedded in multitalker babble. Additionally, there were two visual-only conditions (visible speech, visible speech + gesture). Accuracy levels for both age groups were higher when both visual articulators were present compared to either one or none. However, older adults received a significantly smaller benefit than younger adults, although they performed equally well in speech-only and visual-only word recognition. Individual differences in verbal working memory and inhibitory control partly accounted for age-related performance differences. To conclude, perceiving iconic gestures in addition to visible speech improves younger and older adults’ comprehension of SiN. Yet, the ability to benefit from this additional visual information is modulated by age and verbal working memory. Future research will have to show whether these findings extend beyond the single word level.

Abstract

Speakers can adapt their speech and co-speech gestures based on knowledge shared with an addressee (common ground-based recipient design). Here, we investigate whether these adaptations are modulated by the speaker’s age and cognitive abilities. Younger and older participants narrated six short comic stories to a same-aged addressee. Half of each story was known to both participants, the other half only to the speaker. The two age groups did not differ in terms of the number of words and narrative events mentioned per narration, or in terms of gesture frequency, gesture rate, or percentage of events expressed multimodally. However, only the younger participants reduced the amount of verbal and gestural information when narrating mutually known as opposed to novel story content. Age-related differences in cognitive abilities did not predict these differences in common ground-based recipient design. The older participants’ communicative behaviour may therefore also reflect differences in social or pragmatic goals.

Abstract

We tested whether statistical averageness (SA) at the level of the individual speaker could predict a speaker’s intelligibility. 28 female and 21 male speakers of Dutch were recorded producing 336 sentences,
each containing two target nouns. Recordings were compared to those of all other same-sex speakers using dynamic time warping (DTW). For each sentence, the DTW distance constituted a metric
of phonetic distance from one speaker to all other speakers. SA comprised the average of these distances. Later, the same participants performed a word recognition task on the target nouns in the same sentences, under three degraded listening conditions. In all three conditions, accuracy increased with SA. This held even when participants listened to their own utterances. These findings suggest that listeners process speech with respect to the statistical
properties of the language spoken in their community, rather than using their own speech as a reference

Abstract

Background

Voluntary shifts of visuospatial attention are associated with a lateralization of parieto-occipital alpha power (7-13Hz), i.e. higher power in the hemisphere ipsilateral and lower power contralateral to the locus of attention. Recent noninvasive neuromodulation studies demonstrated that alpha power can be experimentally increased using transcranial alternating current stimulation (tACS).
Objective/Hypothesis

We hypothesized that tACS at alpha frequency over the left parietal cortex induces shifts of attention to the left hemifield. However, spatial attention shifts not only occur voluntarily (endogenous/ top-down), but also stimulus-driven (exogenous/ bottom-up). To study the task-specificity of the potential effects of tACS on attentional processes, we administered three conceptually different spatial attention tasks.
Methods

36 healthy volunteers were recruited from an academic environment. In two separate sessions, we applied either high-density tACS at 10Hz, or sham tACS, for 35–40 minutes to their left parietal cortex. We systematically compared performance on endogenous attention, exogenous attention, and stimulus detection tasks.
Results

In the endogenous attention task, a greater leftward bias in reaction times was induced during left parietal 10Hz tACS as compared to sham. There were no stimulation effects in either the exogenous attention or the stimulus detection task.
Conclusion

The study demonstrates that high-density tACS at 10Hz can be used to modulate visuospatial attention performance. The tACS effect is task-specific, indicating that not all forms of attention are equally susceptible to the stimulation.

Abstract

Exposure to trauma strongly increases the risk to develop stress-related psychopathology, such as post-traumatic stress disorder (PTSD) or major depressive disorder (MDD). In addition, liability to develop these moderately heritable disorders is partly determined by common genetic variance, which is starting to be uncovered by genome-wide association studies (GWASs). However, it is currently unknown to what extent genetic vulnerability and trauma interact. We investigated whether genetic risk based on summary statistics of large GWASs for PTSD and MDD predisposed individuals to report an increase in MDD and PTSD symptoms in a prospective military cohort (N = 516) at five time points after deployment to Afghanistan: one month, six months and one, two and five years. Linear regression was used to analyze the contribution of polygenic risk scores (PRSs, at multiple p-value thresholds) and their interaction with deployment-related trauma to the development of PTSD- and depression-related symptoms. We found no main effects of PRSs nor evidence for interactions with trauma on the development of PTSD or depressive symptoms at any of the time points in the five years after military deployment. Our results based on a unique long-term follow-up of a deployed military cohort suggest limited validity of current PTSD and MDD polygenic risk scores, albeit in the presence of minimal severe psychopathology in the target cohort. Even though the predictive value of PRSs will likely benefit from larger sample sizes in discovery and target datasets, progress will probably also depend on (endo)phenotype refinement that in turn will reduce etiological heterogeneity.

Abstract

Encoding the temporal properties of external signals that comprise multimodal events is a major factor guiding everyday experience. However, during the natural aging process, impairments to sensory processing can profoundly affect multimodal temporal perception. Various mechanisms can contribute to temporal perception, and thus it is imperative to understand how each can be affected by age. In the current study, using three different temporal order judgement tasks (unisensory, multisensory, and sensorimotor), we investigated the effects of age on two separate temporal processes: synchronization and integration of multiple signals. These two processes rely on different aspects of temporal information, either the temporal alignment of processed signals or the integration/segregation of signals arising from different modalities, respectively. Results showed that the ability to integrate/segregate multiple signals decreased with age regardless of the task, and that the magnitude of such impairment correlated across tasks, suggesting a widespread mechanism affected by age. In contrast, perceptual synchrony remained stable with age, revealing a distinct intact mechanism. Overall, results from this study suggest that aging has differential effects on temporal processing, and general impairments with aging may impact global temporal sensitivity while context-dependent processes remain unaffected.

Abstract

Like every other social sphere, science is influenced by individual characteristics of researchers. However, for investigations on scientific networks, only little data about the social background of researchers, e.g. social origin, gender, affiliation etc., is available.
This paper introduces ”Take it personally - TIP”, a conceptual model and library currently under development, which aims to support the
semantic enrichment of publication databases with semantically related background information which resides elsewhere in the (semantic) web, such as Wikidata.
The supplementary information enriches the original information in the publication databases and thus facilitates the creation of complex scientific knowledge graphs. Such enrichment helps to improve the scientometric analysis of scientific publications as they can also take social backgrounds of researchers into account and to understand social structure in research communities.

Abstract

The basic idea behind this task is to find out how languages encode basic shape distinctions such as dimensionality, axial geometry, relative size, etc. More specifically, we want to find out (i) which formal means are used cross linguistically to encode basic shape distinctions, and (ii) which are the semantic distinctions that are made in this domain. In languages with many shape-classifiers, these distinctions are encoded (at least partially) in classifiers. In other languages, positional verbs, descriptive modifiers, such as “flat”, “round”, or nouns such as “cube”, “ball”, etc. might be the preferred means. In this context, we also want to investigate what other “grammatical work” shapeencoding expressions possibly do in a given language, e.g. unitization of mass nouns, or anaphoric uses of shape-encoding classifiers, etc. This task further seeks to determine the role of shape-related parameters which underlie the design of objects in the semantics of the system under investigation.

Abstract

Although feedforward activity may suffice for recognizing objects in isolation, additional visual operations that aid object recognition might be needed for real-world scenes. One such additional operation is figure-ground segmentation, extracting the relevant features and locations of the target object while ignoring irrelevant features. In this study of 60 human participants (female and male), we show objects on backgrounds of increasing complexity to investigate whether recurrent computations are increasingly important for segmenting objects from more complex backgrounds. Three lines of evidence show that recurrent processing is critical for recognition of objects embedded in complex scenes. First, behavioral results indicated a greater reduction in performance after masking objects presented on more complex backgrounds, with the degree of impairment increasing with increasing background complexity. Second, electroencephalography (EEG) measurements showed clear differences in the evoked response potentials between conditions around time points beyond feedforward activity, and exploratory object decoding analyses based on the EEG signal indicated later decoding onsets for objects embedded in more complex backgrounds. Third, deep convolutional neural network performance confirmed this interpretation. Feedforward and less deep networks showed a higher degree of impairment in recognition for objects in complex backgrounds compared with recurrent and deeper networks. Together, these results support the notion that recurrent computations drive figure-ground segmentation of objects in complex scenes.SIGNIFICANCE STATEMENT The incredible speed of object recognition suggests that it relies purely on a fast feedforward buildup of perceptual activity. However, this view is contradicted by studies showing that disruption of recurrent processing leads to decreased object recognition performance. Here, we resolve this issue by showing that how object recognition is resolved and whether recurrent processing is crucial depends on the context in which it is presented. For objects presented in isolation or in simple environments, feedforward activity could be sufficient for successful object recognition. However, when the environment is more complex, additional processing seems necessary to select the elements that belong to the object and by that segregate them from the background.

Abstract

Object and scene recognition both require mapping of incoming sensory information to existing conceptual knowledge about the world. A notable finding in brain-damaged patients is that they may show differentially impaired performance for specific categories, such as for “living exemplars”. While numerous patients with category-specific impairments have been reported, the explanations for these deficits remain controversial. In the current study, we investigate the ability of a brain injured patient with a well-established category-specific impairment of semantic memory to perform two categorization experiments: ‘natural’ vs. ‘manmade’ scenes (experiment 1) and objects (experiment 2). Our findings show that the pattern of categorical impairment does not respect the natural versus manmade distinction. This suggests that the impairments may be better explained by differences in visual features, rather than by category membership. Using Deep Convolutional Neural Networks (DCNNs) as ‘artificial animal models’ we further explored this idea. Results indicated that DCNNs with ‘lesions’ in higher order layers showed similar response patterns, with decreased relative performance for manmade scenes (experiment 1) and natural objects (experiment 2), even though they have no semantic category knowledge, apart from a mapping between pictures and labels. Collectively, these results suggest that the direction of category-effects to a large extent depends, at least in MS′ case, on the degree of perceptual differentiation called for, and not semantic knowledge.

Abstract

Feedforward deep convolutional neural networks (DCNNs) are matching and even surpassing human performance on object recognition. This performance suggests that activation of a loose collection of image
features could support the recognition of natural object categories, without dedicated systems to solve specific visual subtasks. Recent findings in humans however, suggest that while feedforward activity may suffice for
sparse scenes with isolated objects, additional visual operations ('routines') that aid the recognition process (e.g. segmentation or grouping) are needed for more complex scenes. Linking human visual processing to
performance of DCNNs with increasing depth, we here explored if, how, and when object information is differentiated from the backgrounds they appear on. To this end, we controlled the information in both objects
and backgrounds, as well as the relationship between them by adding noise, manipulating background congruence and systematically occluding parts of the image. Results indicated less distinction between object- and background features for more shallow networks. For those networks, we observed a benefit of training on segmented objects (as compared to unsegmented objects). Overall, deeper networks trained on natural
(unsegmented) scenes seem to perform implicit 'segmentation' of the objects from their background, possibly by improved selection of relevant features.

Abstract

This project aims to investigate how speakers of various languages in indigenous cultures verbally reason about moral issues. The ways in which a solution for a moral problem is found, phrased and justified will be taken as the basis for researching reasoning processes that manifest themselves verbally in the speakers’ arguments put forward to solve a number of moral problems which will be presented to them in the form of unfinished story plots or scenarios that ask for a solution. The plots chosen attempt to present common problems in human society and human behaviour. They should function to elicit moral discussion and/or moral arguments in groups of consultants of at least three persons.

Abstract

Die Sprachwissenschaft hat den Begriff und das Konzept ›Rituelle Kommunikation‹ von der vergleichenden Verhaltensforschung übernommen. Humanethologen unterscheiden eine Reihe von sogenannten ›Ausdrucksbewegungen‹, die in der Mimik, der Gestik, der Personaldistanz (Proxemik) und der Körperhaltung (Kinesik) zum Ausdruck kommen. Viele dieser Ausdrucksbewegungen haben sich zu spezifischen Signalen entwickelt. Ethologen definieren Ritualisierung als Veränderung von Verhaltensweisen im Dienst der Signalbildung. Die zu Signalen ritualisierten Verhaltensweisen sind Rituale. Im Prinzip kann jede Verhaltensweise zu einem Signal werden, entweder im Laufe der Evolution oder durch Konventionen, die in einer bestimmten Gemeinschaft gültig sind, die solche Signale kulturell entwickelt hat und die von ihren Mitgliedern tradiert und gelernt werden.

Abstract

Contrary to received opinion, the Aristotelian Square of Opposition (square) is logically sound, differing from standard modern predicate logic (SMPL) only in that it restricts the universe U of cognitively constructible situations by banning null predicates, making it less unnatural than SMPL. U-restriction strengthens the logic without making it unsound. It also invites a cognitive approach to logic. Humans are endowed with a cognitive predicate logic (CPL), which checks the process of cognitive modelling (world construal) for consistency. The square is considered a first approximation to CPL, with a cognitive set-theoretic semantics. Not being cognitively real, the null set Ø is eliminated from the semantics of CPL. Still rudimentary in Aristotle’s On Interpretation (Int), the square was implicitly completed in his Prior Analytics (PrAn), thereby introducing U-restriction. Abelard’s reconstruction of the logic of Int is logically and historically correct; the loca (Leaking O-Corner Analysis) interpretation of the square, defended by some modern logicians, is logically faulty and historically untenable. Generally, U-restriction, not redefining the universal quantifier, as in Abelard and loca, is the correct path to a reconstruction of CPL. Valuation Space modelling is used to compute the effects of U-restriction.

Abstract

Semantic Syntax (SeSyn), originally called Generative Semantics, is an offshoot of Chomskyan generative grammar (ChoGG), rejected by Chomsky and his school in the late 1960s. SeSyn is the theory of algorithmical grammars producing the well-formed sentences of a language L from the corresponding semantic input, the Semantic Analysis (SA), represented as a traditional tree structure diagram in a specific formal language of incremental predicate logic with quantifying and qualifying operators (including the truth functions), and with all lexical items filled in. A SeSyn-type grammar is thus by definition transformational, but not generative. The SA originates in cognition in a manner that is still largely mysterious, but its actual form can be distilled from the Surface Structure (SS) of the sentences of L following the principles set out in SeSyn. In this presentation we provide a more or less technical résumé of the SeSyn theory. A comparison is made with ChoGG-type grammars, which are rejected on account of their intrinsic unsuitability as a cognitive-realist grammar model. The ChoGG model follows the pattern of a 1930s neopositivist Carnap-type grammar for formal logical languages. Such grammars are random sentence generators, whereas, obviously, (nonpathological) humans are not. A ChoGG-type grammar is fundamentally irreconcilable with a mentalist-realist theory of grammar. The body of the paper consists in a demonstration of the production of an English and a French sentence, the latter containing a classic instance of the cyclic rule of Predicate Raising (PR), essential in the general theory of clausal complementation yet steadfastly repudiated in ChoGG for reasons that have never been clarified. The processes and categories defined in SeSyn are effortlessly recognised in languages all over the world, whether indigenous or languages of a dominant culture—taking into account language-specific values for the general theoretical parameters involved. This property makes SeSyn particularly relevant for linguistic typology, which now ranks as the most promising branch of linguistics but has so far conspicuously lacked an adequate theoretical basis.

Abstract

One of the challenges in speech perception is that listeners must deal with considerable
segmental and suprasegmental variability in the acoustic signal due to differences between talkers. Most previous studies have focused on how listeners deal with segmental variability.
In this EEG experiment, we investigated whether listeners track talker-specific usage of suprasegmental cues to lexical stress to recognize spoken words correctly. In a three-day training phase, Dutch participants learned to map non-word minimal stress pairs onto different object referents (e.g., USklot meant “lamp”; usKLOT meant “train”). These non-words were
produced by two male talkers. Critically, each talker used only one suprasegmental cue to signal stress (e.g., Talker A used only F0 and Talker B only intensity). We expected participants to learn which talker used which cue to signal stress. In the test phase, participants indicated whether spoken sentences including these non-words were correct (“The word for lamp is…”).
We found that participants were slower to indicate that a stimulus was correct if the non-word was produced with the unexpected cue (e.g., Talker A using intensity). That is, if in training Talker A used F0 to signal stress, participants experienced a mismatch between predicted and perceived phonological word-forms if, at test, Talker A unexpectedly used intensity to cue
stress. In contrast, the N200 amplitude, an event-related potential related to phonological
prediction, was not modulated by the cue mismatch. Theoretical implications of these
contrasting results are discussed. The behavioral findings illustrate talker-specific prediction of prosodic cues, picked up through perceptual learning during training.

Abstract

The Open Access Movement promotes free and unfettered access to research publications and, increasingly, to the primary data which underly those publications. As the field of documentary linguistics seeks to record and preserve culturally and linguistically relevant materials, the question of how openly accessible these materials should be becomes increasingly important. This paper aims to guide researchers and other stakeholders in finding an appropriate balance between accessibility and confidentiality of data, addressing community questions and legal, institutional, and intellectual issues that pose challenges to accessible data.

Abstract

Autism spectrum disorder is increasingly associated with atypical perceptual and sensory symptoms. Here we explore the hypothesis
that aberrant sensory processing in autism spectrum disorder could be linked to atypical intra- (local) and interregional (global)
brain connectivity. To elucidate oscillatory dynamics and connectivity in the visual domain we used magnetoencephalography and
a simple visual grating paradigm with a group of 18 adolescent autistic participants and 18 typically developing control subjects.
Both groups showed similar increases in gamma (40–80 Hz) and decreases in alpha (8–13 Hz) frequency power in occipital cortex.
However, systematic group differences emerged when analysing intra- and interregional connectivity in detail. First, directed
connectivity was estimated using non-parametric Granger causality between visual areas V1 and V4. Feedforward V1-to-V4
connectivity, mediated by gamma oscillations, was equivalent between autism spectrum disorder and control groups, but importantly,
feedback V4-to-V1 connectivity, mediated by alpha (8–13 Hz) oscillations, was significantly reduced in the autism spectrum
disorder group. This reduction was positively correlated with autistic quotient scores, consistent with an atypical visual hierarchy
in autism, characterized by reduced top-down modulation of visual input via alpha-band oscillations. Second, at the local level in
V1, coupling of alpha-phase to gamma amplitude (alpha-gamma phase amplitude coupling) was reduced in the autism spectrum
disorder group. This implies dysregulated local visual processing, with gamma oscillations decoupled from patterns of wider alphaband
phase synchrony (i.e. reduced phase amplitude coupling), possibly due to an excitation-inhibition imbalance. More generally,
these results are in agreement with predictive coding accounts of neurotypical perception and indicate that visual processes in
autism are less modulated by contextual feedback information.

Abstract

Autism spectrum disorder (ASD) and schizophrenia have been conceived as partly opposing disorders in terms of systemizing versus empathizing cognitive styles, with resemblances to male versus female average sex differences. Left-right asymmetry of the brain is an important aspect of its organization that shows average differences between the sexes, and can be altered in both ASD and schizophrenia. Here we mapped multivariate associations of polygenic risk scores for ASD and schizophrenia with asymmetries of regional cerebral cortical surface area, thickness and subcortical volume measures in 32,256 participants from the UK Biobank. Polygenic risks for the two disorders were positively correlated (r=0.08, p=7.13×10-50), and both were higher in females compared to males, consistent with biased participation against higher-risk males. Each polygenic risk score was associated with multivariate brain asymmetry after adjusting for sex, ASD r=0.03, p=2.17×10-9, schizophrenia r=0.04, p=2.61×10-11, but the multivariate patterns were mostly distinct for the two polygenic risks, and neither resembled average sex differences. Annotation based on meta-analyzed functional imaging data showed that both polygenic risks were associated with asymmetries of regions important for language and executive functions, consistent with behavioural associations that arose in phenome-wide association analysis. Overall, the results indicate that distinct patterns of subtly altered brain asymmetry may be functionally relevant manifestations of polygenic risks for ASD and schizophrenia, but do not support brain masculinization or feminization in their etiologies.

Abstract

Roughly 10% of the human population is left-handed, and this rate is increased in some brain-related disorders. The neuroanatomical correlates of hand preference have remained equivocal. We resampled structural brain image data from 28,802 right-handers and 3,062 left-handers (UK Biobank population dataset) to a symmetrical surface template, and mapped asymmetries for each of 8,681 vertices across the cerebral cortex in each individual. Left-handers compared to right-handers showed average differences of surface area asymmetry within the fusiform cortex, the anterior insula, the anterior middle cingulate cortex, and the precentral cortex. Meta-analyzed functional imaging data implicated these regions in executive functions and language. Polygenic disposition to left-handedness was associated with two of these regional asymmetries, and 18 loci previously linked with left-handedness by genome-wide screening showed associations with one or more of these asymmetries. Implicated genes included six encoding microtubule-related proteins: TUBB, TUBA1B, TUBB3, TUBB4A, MAP2, and NME7—mutations in the latter can cause left to right reversal of the visceral organs. There were also two cortical regions where average thickness asymmetry was altered in left-handedness: on the postcentral gyrus and the inferior occipital cortex, functionally annotated with hand sensorimotor and visual roles. These cortical thickness asymmetries were not heritable. Heritable surface area asymmetries of language-related regions may link the etiologies of hand preference and language, whereas nonheritable asymmetries of sensorimotor cortex may manifest as consequences of hand preference.

Abstract

Left–right hemispheric asymmetry is an important aspect of healthy brain organization for many functions including language, and it can be altered in cognitive and psychiatric disorders. No mechanism has yet been identified for establishing the human brain’s left–right axis. We performed multivariate genome-wide association scanning of cortical regional surface area and thickness asymmetries, and subcortical volume asymmetries, using data from 32,256 participants from the UK Biobank. There were 21 significant loci associated with different aspects of brain asymmetry, with functional enrichment involving microtubule-related genes and embryonic brain expression. These findings are consistent with a known role of the cytoskeleton in left–right axis determination in other organs of invertebrates and frogs. Genetic variants associated with brain asymmetry overlapped with those associated with autism, educational attainment and schizophrenia. Comparably large datasets will likely be required in future studies, to replicate and further clarify the associations of microtubule-related genes with variation in brain asymmetry, behavioural and psychiatric traits.

Abstract

Background Cognitive dysfunction is one of the most prominent characteristics of psychiatric disorders. At present, the neural correlates of cognitive dysfunction across psychiatric disorders are poorly understood. The aim of this study was to investigate functional connectivity and structural perturbations across psychiatric diagnoses in three neurocognitive networks of interest, including the default-mode (DMN), the frontoparietal (FPN) and the salience network (SN). Methods We performed meta-analyses of resting-state functional MRI (R-fMRI) whole-brain seed-based functional connectivity in 8,298 patients (involving 8 disorders) and 8,165 healthy controls and a voxel-based morphometry analysis of structural MRI data in 14,027 patients (involving 8 disorders) and healthy 14,504 controls. To aid the interpretation of the results, we examined neurocognitive function in 776 healthy participants from the Human Connectome Project. Results We found that the three neurocognitive networks of interest were characterized by shared alterations of functional connectivity architecture across psychiatric disorders. More specifically, hypoconnectivity was expressed between the DMN and ventral SN and between the SN and FPN, whereas hyperconnectivity was evident between the DMN and FPN and between the DMN and dorsal SN. This pattern of network alterations was associated with gray matter reductions in patients, and was localized in regions that subserve general cognitive performance. Conclusions This study is the first to provide meta-analytic evidence of common alterations of functional connectivity within and between neurocognitive networks. The findings suggest a shared mechanism of network interactions that may associate with the generalized cognitive deficits observed in psychiatric disorders.

Abstract

There is mounting evidence that the ease of producing and understanding language depends not only on the frequencies of individual words but also on the frequencies of word combinations. However, in two picture description experiments, Janssen and Barber (2012) found that French and Spanish speakers' speech onset latencies for short phrases depended exclusively on the frequencies of the phrases but not on the frequencies of the individual words. They suggested that speakers retrieved phrase-sized units from the mental lexicon. In the present study, we examined whether the time required to plan complex noun phrases in Dutch would likewise depend only on phrase frequencies. Participants described line drawings in phrases such as rode schoen [red shoe] (Experiments 1 and 2) or de rode schoen [the red shoe] (Experiment 3). Replicating Janssen and Barber's findings, utterance onset latencies depended on the frequencies of the phrases but, deviating from their findings, also depended on the frequencies of the adjectives in adjective-noun phrases and the frequencies of the nouns in determiner-adjective-noun phrases. We conclude that individual word frequencies and phrase frequencies both affect the time needed to produce noun phrases and discuss how these findings may be captured in models of the mental lexicon and of phrase production

Abstract

Several abilities outside literacy proper are associated with reading and spelling, both phenotypically and genetically, though our knowledge of multivariate genomic covariance structures is incomplete. Here, we introduce structural models describing genetic and residual influences between traits to study multivariate links across measures of literacy, phonological awareness, oral language, and phonological working memory (PWM) in unrelated UK youth (8-13 years, N=6,453). We find that all phenotypes share a large proportion of underlying genetic variation, although especially oral language and PWM reveal substantial differences in their genetic variance composition with substantial trait-specific genetic influences. Multivariate genetic and residual trait covariance showed concordant patterns, except for marked differences between oral language and literacy/phonological awareness, where strong genetic links contrasted near-zero residual overlap. These findings suggest differences in etiological mechanisms, acting beyond a pleiotropic set of genetic variants, and implicate variation in trait modifiability even among phenotypes that have high genetic correlations.

Abstract

Interactions between top-down and bottom-up information streams are integral to brain function but challenging to measure noninvasively. Laminar resolution, functional MRI (lfMRI) is sensitive to depth-dependent properties of the blood oxygen level-dependent (BOLD) response, which can be potentially related to top-down and bottom-up signal contributions. In this work, we used lfMRI to dissociate the top-down and bottom-up signal contributions to the left occipitotemporal sulcus (LOTS) during word reading. We further demonstrate that laminar resolution measurements could be used to identify condition-specific distributed networks on the basis of whole-brain connectivity patterns specific to the depth-dependent BOLD signal. The networks corresponded to top-down and bottom-up signal pathways targeting the LOTS during word reading. We show that reading increased the top-down BOLD signal observed in the deep layers of the LOTS and that this signal uniquely related to the BOLD response in other language-critical regions. These results demonstrate that lfMRI can reveal important patterns of activation that are obscured at standard resolution. In addition to differences in activation strength as a function of depth, we also show meaningful differences in the interaction between signals originating from different depths both within a region and with the rest of the brain. We thus show that lfMRI allows the noninvasive measurement of directed interaction between brain regions and is capable of resolving different connectivity patterns at submillimeter resolution, something previously considered to be exclusively in the domain of invasive recordings.

Abstract

ndividual talkers may use various strategies to enrich their speech while speaking in noise (i.e., Lombard speech) to improve their intelligibility. The resulting acoustic-phonetic changes in Lombard speech vary amongst different speakers, but it is unclear what causes these talker differences, and what impact these differences have on intelligibility. This study investigates the potential role of articulatory control in talkers’ Lombard speech enrichment success. Seventy-eight speakers read out sentences in both their habitual style and in a condition where they were instructed to speak clearly while hearing loud speech-shaped noise. A diadochokinetic (DDK) speech task that requires speakers to repetitively produce word or non-word sequences as accurately and as rapidly as possible, was used to quantify their articulatory control. Individuals’ predicted intelligibility in both speaking styles (presented at -5 dB SNR) was measured using an acoustic glimpse-based metric: the High-Energy Glimpse Proportion (HEGP). Speakers’ HEGP scores show a clear effect of speaking condition (better HEGP scores in the Lombard than habitual condition), but no simple effect of articulatory control on HEGP, nor an interaction between speaking condition and articulatory control. This indicates that individuals’ speech enrichment success as measured by the HEGP metric was not predicted by DDK performance.