Publications

Displaying 801 - 838 of 838
  • Warner, N., Jongman, A., Sereno, J., & Kemps, R. J. J. K. (2004). Incomplete neutralization and other sub-phonemic durational differences in production and perception: Evidence from Dutch. Journal of Phonetics, 32(2), 251-276. doi:10.1016/S0095-4470(03)00032-9.

    Abstract

    Words which are expected to contain the same surface string of segments may, under identical prosodic circumstances, sometimes be realized with slight differences in duration. Some researchers have attributed such effects to differences in the words’ underlying forms (incomplete neutralization), while others have suggested orthographic influence and extremely careful speech as the cause. In this paper, we demonstrate such sub-phonemic durational differences in Dutch, a language which some past research has found not to have such effects. Past literature has also shown that listeners can often make use of incomplete neutralization to distinguish apparent homophones. We extend perceptual investigations of this topic, and show that listeners can perceive even durational differences which are not consistently observed in production. We further show that a difference which is primarily orthographic rather than underlying can also create such durational differences. We conclude that a wide variety of factors, in addition to underlying form, can induce speakers to produce slight durational differences which listeners can also use in perception.
  • Warren, J. E., Sauter, D., Eisner, F., Wiland, J., Dresner, M. A., Wise, R. J. S., Rosen, S., & Scott, S. K. (2006). Positive emotions preferentially engage an auditory–motor “mirror” system. The Journal of Neuroscience, 26(50), 13067-13075. doi:10.1523/JNEUROSCI.3907-06.2006.

    Abstract

    Social interaction relies on the ability to react to communication signals. Although cortical sensory–motor “mirror” networks are thought to play a key role in visual aspects of primate communication, evidence for a similar generic role for auditory–motor interaction in primate nonverbal communication is lacking. We demonstrate that a network of human premotor cortical regions activated during facial movement is also involved in auditory processing of affective nonverbal vocalizations. Within this auditory–motor mirror network, distinct functional subsystems respond preferentially to emotional valence and arousal properties of heard vocalizations. Positive emotional valence enhanced activation in a left posterior inferior frontal region involved in representation of prototypic actions, whereas increasing arousal enhanced activation in presupplementary motor area cortex involved in higher-order motor control. Our findings demonstrate that listening to nonverbal vocalizations can automatically engage preparation of responsive orofacial gestures, an effect that is greatest for positive-valence and high-arousal emotions. The automatic engagement of responsive orofacial gestures by emotional vocalizations suggests that auditory–motor interactions provide a fundamental mechanism for mirroring the emotional states of others during primate social behavior. Motor facilitation by positive vocal emotions suggests a basic neural mechanism for establishing cohesive bonds within primate social groups.
  • Wassenaar, M., & Hagoort, P. (2005). Word-category violations in patients with Broca's aphasia: An ERP study. Brain and Language, 92, 117-137. doi:10.1016/j.bandl.2004.05.011.

    Abstract

    An event-related brain potential experiment was carried out to investigate on-line syntactic processing in patients with Broca’s aphasia. Subjects were visually presented with sentences that were either syntactically correct or contained violations of word-category. Three groups of subjects were tested: Broca patients (N=11), non-aphasic patients with a right hemisphere (RH) lesion (N=9), and healthy aged-matched controls (N=15). Both control groups appeared sensitive to the violations of word-category as shown by clear P600/SPS effects. The Broca patients displayed only a very reduced and delayed P600/SPS effect. The results are discussed in the context of a lexicalist parsing model. It is concluded that Broca patients are hindered to detect on-line violations of word-category, if word class information is incomplete or delayed available.
  • Wassenaar, M., Brown, C. M., & Hagoort, P. (2004). ERP-effects of subject-verb agreement violations in patients with Broca's aphasia. Journal of Cognitive Neuroscience, 16(4), 553-576. doi:10.1162/089892904323057290.

    Abstract

    This article presents electrophysiological data on on-line syntactic processing during auditory sentence comprehension in patients with Broca's aphasia. Event-related brain potentials (ERPs) were recorded from the scalp while subjects listened to sentences that were either syntactically correct or contained violations of subject-verb agreement. Three groups of subjects were tested: Broca patients (n = 10), nonaphasic patients with a right-hemisphere (RH) lesion (n = 5), and healthy agedmatched controls (n = 12). The healthy, control subjects showed a P600/SPS effect as response to the agreement violations. The nonaphasic patients with an RH lesion showed essentially the same pattern. The overall group of Broca patients did not show this sensitivity. However, the sensitivity was modulated by the severity of the syntactic comprehension impairment. The largest deviation from the standard P600/SPS effect was found in the patients with the relatively more severe syntactic comprehension impairment. In addition, ERPs to tones in a classical tone oddball paradigm were also recorded. Similar to the normal control subjects and RH patients, the group of Broca patients showed a P300 effect in the tone oddball condition. This indicates that aphasia in itself does not lead to a general reduction in all cognitive ERP effects. It was concluded that deviations from the standard P600/SPS effect in the Broca patients reflected difficulties with on-line maintaining of number information across clausal boundaries for establishing subject-verb agreement.
  • Weber, A., Braun, B., & Crocker, M. W. (2006). Finding referents in time: Eye-tracking evidence for the role of contrastive accents. Language and Speech, 49(3), 367-392.

    Abstract

    In two eye-tracking experiments the role of contrastive pitch accents during the on-line determination of referents was examined. In both experiments, German listeners looked earlier at the picture of a referent belonging to a contrast pair (red scissors, given purple scissors) when instructions to click on it carried a contrastive accent on the color adjective (L + H*) than when the adjective was not accented. In addition to this prosodic facilitation, a general preference to interpret adjectives contrastively was found in Experiment 1: Along with the contrast pair, a noncontrastive referent was displayed (red vase) and listeners looked more often at the contrastive referent than at the noncontrastive referent even when the adjective was not focused. Experiment 2 differed from Experiment 1 in that the first member of the contrast pair (purple scissors) was introduced with a contrastive accent, thereby strengthening the salience of the contrast. In Experiment 2, listeners no longer preferred a contrastive interpretation of adjectives when the accent in a subsequent instruction was not contrastive. In sum, the results support both an early role for prosody in reference determination and an interpretation of contrastive focus that is dependent on preceding prosodic context.
  • Weber, A., & Cutler, A. (2006). First-language phonotactics in second-language listening. Journal of the Acoustical Society of America, 119(1), 597-607. doi:10.1121/1.2141003.

    Abstract

    Highly proficient German users of English as a second language, and native speakers of American English, listened to nonsense sequences and responded whenever they detected an embedded English word. The responses of both groups were equivalently facilitated by preceding context that both by English and by German phonotactic constraints forced a boundary at word onset (e.g., lecture was easier to detect in moinlecture than in gorklecture, and wish in yarlwish than in plookwish. The American L1 speakers’ responses were strongly facilitated, and the German listeners’ responses almost as strongly facilitated, by contexts that forced a boundary in English but not in German thrarshlecture, glarshwish. The German listeners’ responses were significantly facilitated also by contexts that forced a boundary in German but not in English )moycelecture, loitwish, while L1 listeners were sensitive to acoustic boundary cues in these materials but not to the phonotactic sequences. The pattern of results suggests that proficient L2 listeners can acquire the phonotactic probabilities of an L2 and use them to good effect in segmenting continuous speech, but at the same time they may not be able to prevent interference from L1 constraints in their L2 listening.
  • Weber, A., & Cutler, A. (2004). Lexical competition in non-native spoken-word recognition. Journal of Memory and Language, 50(1), 1-25. doi:10.1016/S0749-596X(03)00105-0.

    Abstract

    Four eye-tracking experiments examined lexical competition in non-native spoken-word recognition. Dutch listeners hearing English fixated longer on distractor pictures with names containing vowels that Dutch listeners are likely to confuse with vowels in a target picture name (pencil, given target panda) than on less confusable distractors (beetle, given target bottle). English listeners showed no such viewing time difference. The confusability was asymmetric: given pencil as target, panda did not distract more than distinct competitors. Distractors with Dutch names phonologically related to English target names (deksel, ‘lid,’ given target desk) also received longer fixations than distractors with phonologically unrelated names. Again, English listeners showed no differential effect. With the materials translated into Dutch, Dutch listeners showed no activation of the English words (desk, given target deksel). The results motivate two conclusions: native phonemic categories capture second-language input even when stored representations maintain a second-language distinction; and lexical competition is greater for non-native than for native listeners.
  • Weber, A., & Cutler, A. (2003). Perceptual similarity co-existing with lexical dissimilarity [Abstract]. Abstracts of the 146th Meeting of the Acoustical Society of America. Journal of the Acoustical Society of America, 114(4 Pt. 2), 2422. doi:10.1121/1.1601094.

    Abstract

    The extreme case of perceptual similarity is indiscriminability, as when two second‐language phonemes map to a single native category. An example is the English had‐head vowel contrast for Dutch listeners; Dutch has just one such central vowel, transcribed [E]. We examine whether the failure to discriminate in phonetic categorization implies indiscriminability in other—e.g., lexical—processing. Eyetracking experiments show that Dutch‐native listeners instructed in English to ‘‘click on the panda’’ look (significantly more than native listeners) at a pictured pencil, suggesting that pan‐ activates their lexical representation of pencil. The reverse, however, is not the case: ‘‘click on the pencil’’ does not induce looks to a panda, suggesting that pen‐ does not activate panda in the lexicon. Thus prelexically undiscriminated second‐language distinctions can nevertheless be maintained in stored lexical representations. The problem of mapping a resulting unitary input to two distinct categories in lexical representations is solved by allowing input to activate only one second‐language category. For Dutch listeners to English, this is English [E], as a result of which no vowels in the signal ever map to words containing [ae]. We suggest that the choice of category is here motivated by a more abstract, phonemic, metric of similarity.
  • Weber, A., Grice, M., & Crocker, M. W. (2006). The role of prosody in the interpretation of structural ambiguities: A study of anticipatory eye movements. Cognition, 99, B63-B72. doi:10.1016/j.cognition.2005.07.001.

    Abstract

    An eye-tracking experiment examined whether prosodic cues can affect the interpretation of grammatical functions in the absence of clear morphological information. German listeners were presented with scenes depicting three potential referents while hearing temporarily ambiguous SVO and OVS sentences. While case marking on the first noun phrase (NP) was ambiguous, clear case marking on the second NP disambiguated sentences towards SVO or OVS. Listeners interpreted caseambiguous NP1s more often as Subject, and thus expected an Object as upcoming argument, only when sentence beginnings carried an SVO-type intonation. This was revealed by more anticipatory eye movements to suitable Patients (Objects) than Agents (Subjects) in the visual scenes. No such preference was found when sentence beginnings had a clearly OVS-type intonation. Prosodic cues were integrated rapidly enough to affect listeners’ interpretation of grammatical function before disambiguating case information was available. We conclude that in addition to manipulating attachment ambiguities, prosody can influence the interpretation of constituent order ambiguities.
  • Wegener, C. (2006). Savosavo body part terminology. Language Sciences, 28(2-3), 344-359. doi:10.1016/j.langsci.2005.11.005.

    Abstract

    This paper provides a description of body part terminology used in Savosavo, a Papuan language of the Solomon Islands. The first part of the paper lists the known terms and discusses their meanings. This is followed by an analysis of their structural properties. Finally, the paper discusses partonomic relations in Savosavo and argues that it is difficult to structure the body part terminology hierarchically, because there is no linguistic evidence for part–whole relations between body parts.
  • Wegener, C. (2005). Major word classes in Savosavo. Grazer Linguistische Studien, 64, 29-52.
  • Weisfelt, M., Hoogman, M., van de Beek, D., de Gans, J., Dreschler, W. A., & Schmand, B. A. (2006). Dexamethasone and long-term outcome in adults with bacterial meningitis. Annals of Neurology, 60, 456-468. doi:10.1002/ana.20944.

    Abstract

    This follow-up study of the European Dexamethasone Study was designed to examine the potential harmful effect of adjunctive dexamethasone treatment on long-term neuropsychological outcome in adults with bacterial meningitis. METHODS: Neurological, audiological, and neuropsychological examinations were performed in adults who survived pneumococcal or meningococcal meningitis. RESULTS: Eighty-seven of 99 (88%) eligible patients were included in the follow-up study; 46 (53%) were treated with dexamethasone and 41 (47%) with placebo. Median time between meningitis and testing was 99 months. Neuropsychological evaluation showed no significant differences between patients treated with dexamethasone and placebo. The proportions of patients with persisting neurological sequelae or hearing loss were similar in the dexamethasone and placebo groups. The overall rate of cognitive dysfunction did not differ significantly between patients and control subjects; however, patients after pneumococcal meningitis had a higher rate of cognitive dysfunction (21 vs 6%; p = 0.05) and experienced more impairment of everyday functioning due to physical problems (p = 0.05) than those after meningococcal meningitis. INTERPRETATION: Treatment with adjunctive dexamethasone is not associated with an increased risk for long-term cognitive impairment. Adults who survive pneumococcal meningitis are at significant risk for long-term neuropsychological abnormalities.
  • Weisfelt, M., van de Beek, D., Hoogman, M., Hardeman, C., de Gans, J., & Schmand, B. (2006). Cognitive outcome in adults with moderate disability after pneumococcal meningitis. Journal of Infection, 52, 433-439. doi:10.1016/j.jinf.2005.08.014.

    Abstract

    Objectives To assess cognitive outcome and quality of life in patients with moderate disability after bacterial meningitis as compared to patients with good recovery. Methods Neuropsychological evaluation was performed in 40 adults after pneumococcal meningitis; 20 patients with moderate disability at discharge on the glasgow outcome scale (GOS score 4) and 20 with good recovery (GOS score 5). Results Patients with GOS score 4 had similar test results as compared to patients with GOS score 5 for the neuropsychological domains ‘intelligence’, ‘memory’ and ‘attention and executive functioning’. Patients with GOS score 4 showed less cognitive slowness than patients with GOS score 5. In a linear regression analysis cognitive speed was related to current intelligence, years of education and time since meningitis. Overall performance on the speed composite score correlated significantly with time since meningitis (−0.62; P<0.001). Therefore, difference between both groups may have been related to a longer time between meningitis and testing for GOS four patients (29 vs. 12 months; P<0.001). Conclusions Patients with moderate disability after bacterial meningitis are not at higher risk for neuropsychological abnormalities than patients with good recovery. In addition, cognitive slowness after bacterial meningitis may be reversible in time.
  • Wheeldon, L. (2003). Inhibitory from priming of spoken word production. Language and Cognitive Processes, 18(1), 81-109. doi:10.1080/01690960143000470.

    Abstract

    Three experiments were designed to examine the effect on picture naming of the prior production of a word related in phonological form. In Experiment 1, the latency to produce Dutch words in response to pictures (e.g., hoed , hat) was longer following the production of a form-related word (e.g., hond , dog) in response to a definition on a preceding trial, than when the preceding definition elicited an unrelated word (e.g., kerk , church). Experiment 2 demonstrated that the inhibitory effect disappears when one unrelated word is produced intervening prime and target productions (e.g., hond-kerk-hoed ). The size of the inhibitory effect was not significantly affected by the frequency of the prime words or the target picture names. In Experiment 3, facilitation was observed for word pairs that shared offset segments (e.g., kurk-jurk , cork-dress), whereas inhibition was observed for shared onset segments (e.g., bloed-bloem , blood-flower). However, no priming was observed for prime and target words with shared phonemes but no mismatching segments (e.g., oom-boom , uncle-tree; hex-hexs , fence-witch). These findings are consistent with a process of phoneme competition during phonological encoding.
  • Whelan, L., Dockery, A., Stephenson, K. A. J., Zhu, J., Kopčić, E., Post, I. J. M., Khan, M., Corradi, Z., Wynne, N., O’ Byrne, J. J., Duignan, E., Silvestri, G., Roosing, S., Cremers, F. P. M., Keegan, D. J., Kenna, P. F., & Farrar, G. J. (2023). Detailed analysis of an enriched deep intronic ABCA4 variant in Irish Stargardt disease patients. Scientific Reports, 13: 9380. doi:10.1038/s41598-023-35889-9.

    Abstract

    Over 15% of probands in a large cohort of more than 1500 inherited retinal degeneration patients present with a clinical diagnosis of Stargardt disease (STGD1), a recessive form of macular dystrophy caused by biallelic variants in the ABCA4 gene. Participants were clinically examined and underwent either target capture sequencing of the exons and some pathogenic intronic regions of ABCA4, sequencing of the entire ABCA4 gene or whole genome sequencing. ABCA4 c.4539 + 2028C > T, p.[= ,Arg1514Leufs*36] is a pathogenic deep intronic variant that results in a retina-specific 345-nucleotide pseudoexon inclusion. Through analysis of the Irish STGD1 cohort, 25 individuals across 18 pedigrees harbour ABCA4 c.4539 + 2028C > T and another pathogenic variant. This includes, to the best of our knowledge, the only two homozygous patients identified to date. This provides important evidence of variant pathogenicity for this deep intronic variant, highlighting the value of homozygotes for variant interpretation. 15 other heterozygous incidents of this variant in patients have been reported globally, indicating significant enrichment in the Irish population. We provide detailed genetic and clinical characterization of these patients, illustrating that ABCA4 c.4539 + 2028C > T is a variant of mild to intermediate severity. These results have important implications for unresolved STGD1 patients globally with approximately 10% of the population in some western countries claiming Irish heritage. This study exemplifies that detection and characterization of founder variants is a diagnostic imperative.

    Additional information

    supplemental material
  • White, S. A., Fisher, S. E., Geschwind, D. H., Scharff, C., & Holy, T. E. (2006). Singing mice, songbirds, and more: Models for FOXP2 function and dysfunction in human speech and language. The Journal of Neuroscience, 26(41), 10376-10379. doi:10.1523/JNEUROSCI.3379-06.2006.

    Abstract

    In 2001, a point mutation in the forkhead box P2 (FOXP2) coding sequence was identified as the basis of an inherited speech and language disorder suffered by members of the family known as "KE." This mini-symposium review focuses on recent findings and research-in-progress, primarily from five laboratories. Each aims at capitalizing on the FOXP2 discovery to build a neurobiological bridge between molecule and phenotype. Below, we describe genetic through behavioral techniques used currently to investigate FoxP2 in birds, rodents, and humans for discovery of the neural bases of vocal learning and language.
  • Widlok, T. (2004). Ethnography in language Documentation. Language Archive Newsletter, 1(3), 4-6.
  • Wittenburg, P., Skiba, R., & Trilsbeek, P. (2004). Technology and Tools for Language Documentation. Language Archive Newsletter, 1(4), 3-4.
  • Wittenburg, P. (2003). The DOBES model of language documentation. Language Documentation and Description, 1, 122-139.
  • Wittenburg, P., Skiba, R., & Trilsbeek, P. (2005). The language archive at the MPI: Contents, tools, and technologies. Language Archives Newsletter, 5, 7-9.
  • Wittenburg, P. (2004). Training Course in Lithuania. Language Archive Newsletter, 1(2), 6-6.
  • Wittenburg, P., Dirksmeyer, R., Brugman, H., & Klaas, G. (2004). Digital formats for images, audio and video. Language Archive Newsletter, 1(1), 3-6.
  • Wittenburg, P. (2004). International Expert Meeting on Access Management for Distributed Language Archives. Language Archive Newsletter, 1(3), 12-12.
  • Wittenburg, P. (2004). Final review of INTERA. Language Archive Newsletter, 1(4), 11-12.
  • Wittenburg, P. (2004). LinguaPax Forum on Language Diversity, Sustainability, and Peace. Language Archive Newsletter, 1(3), 13-13.
  • Wittenburg, P. (2004). LREC conference 2004. Language Archive Newsletter, 1(3), 12-13.
  • Wittenburg, P. (2004). News from the Archive of the Max Planck Institute for Psycholinguistics. Language Archive Newsletter, 1(4), 12-12.
  • Wurm, L. H., Ernestus, M., Schreuder, R., & Baayen, R. H. (2006). Dynamics of the auditory comprehension of prefixed words: Cohort entropies and conditional root uniqueness points. The Mental Lexicon, 1(1), 125-146.

    Abstract

    This auditory lexical decision study shows that cohort entropies, conditional root uniqueness points, and morphological family size all contribute to the dynamics of the auditory comprehension of prefixed words. Three entropy measures calculated for different positions in the stem of Dutch prefixed words revealed facilitation for higher entropies, except at the point of disambiguation, where we observed inhibition. Morphological family size was also facilitatory, but only for prefixed words in which the conditional root uniqueness point coincided with the conventional uniqueness point. For words with early conditional disambiguation, in contrast, only the morphologically related words that were onset-aligned with the target word facilitated lexical decision.
  • Zeshan, U. (2003). Aspects of Türk Işaret Dili (Turkish Sign Language). Sign Language and Linguistics, 6(1), 43-75. doi:10.1075/sll.6.1.04zes.

    Abstract

    This article provides a first overview of some striking grammatical structures in Türk Idotscedilaret Dili (Turkish Sign Language, TID), the sign language used by the Deaf community in Turkey. The data are described with a typological perspective in mind, focusing on aspects of TID grammar that are typologically unusual across sign languages. After giving an overview of the historical, sociolinguistic and educational background of TID and the language community using this sign language, five domains of TID grammar are investigated in detail. These include a movement derivation signalling completive aspect, three types of nonmanual negation — headshake, backward head tilt, and puffed cheeks — and their distribution, cliticization of the negator NOT to a preceding predicate host sign, an honorific whole-entity classifier used to refer to humans, and a question particle, its history and current status in the language. A final evaluation points out the significance of these data for sign language research and looks at perspectives for a deeper understanding of the language and its history.
  • Zeshan, U. (2004). Interrogative constructions in sign languages - Cross-linguistic perspectives. Language, 80(1), 7-39.

    Abstract

    This article reports on results from a broad crosslinguistic study based on data from thirty-five signed languages around the world. The study is the first of its kind, and the typological generalizations presented here cover the domain of interrogative structures as they appear across a wide range of geographically and genetically distinct signed languages. Manual and nonmanual ways of marking basic types of questions in signed languages are investigated. As a result, it becomes clear that the range of crosslinguistic variation is extensive for some subparameters, such as the structure of question-word paradigms, while other parameters, such as the use of nonmanual expressions in questions, show more similarities across signed languages. Finally, it is instructive to compare the findings from signed language typology to relevant data from spoken languages at a more abstract, crossmodality level.
  • Zeshan, U., Vasishta, M. N., & Sethna, M. (2005). Implementation of Indian Sign Language in educational settings. Asia Pacific Disability Rehabilitation Journal, 16(1), 16-40.

    Abstract

    This article reports on several sub-projects of research and development related to the use of Indian Sign Language in educational settings. In many countries around the world, sign languages are now recognised as the legitimate, full-fledged languages of the deaf communities that use them. In India, the development of sign language resources and their application in educational contexts, is still in its initial stages. The work reported on here, is the first principled and comprehensive effort of establishing educational programmes in Indian Sign Language at a national level. Programmes are of several types: a) Indian Sign Language instruction for hearing people; b) sign language teacher training programmes for deaf people; and c) educational materials for use in schools for the Deaf. The conceptual approach used in the programmes for deaf students is known as bilingual education, which emphasises the acquisition of a first language, Indian Sign Language, alongside the acquisition of spoken languages, primarily in their written form.
  • Zeshan, U. (2004). Hand, head and face - negative constructions in sign languages. Linguistic Typology, 8(1), 1-58. doi:10.1515/lity.2004.003.

    Abstract

    This article presents a typology of negative constructions across a substantial number of sign languages from around the globe. After situating the topic within the wider context of linguistic typology, the main negation strategies found across sign languages are described. Nonmanual negation includes the use of head movements and facial expressions for negation and is of great importance in sign languages as well as particularly interesting from a typological point of view. As far as manual signs are concerned, independent negative particles represent the dominant strategy, but there are also instances of irregular negation in most sign languages. Irregular negatives may take the form of suppletion, cliticisation, affixing, or internal modification of a sign. The results of the study lead to interesting generalisations about similarities and differences between negatives in signed and spoken languages.
  • Zhang, J., Bao, S., Furumai, R., Kucera, K. S., Ali, A., Dean, N. M., & Wang, X.-F. (2005). Protein phosphatase 5 is required for ATR-mediated checkpoint activation. Molecular and Cellular Biology, 25, 9910-9919. doi:10.1128/​MCB.25.22.9910-9919.2005.

    Abstract

    In response to DNA damage or replication stress, the protein kinase ATR is activated and subsequently transduces genotoxic signals to cell cycle control and DNA repair machinery through phosphorylation of a number of downstream substrates. Very little is known about the molecular mechanism by which ATR is activated in response to genotoxic insults. In this report, we demonstrate that protein phosphatase 5 (PP5) is required for the ATR-mediated checkpoint activation. PP5 forms a complex with ATR in a genotoxic stress-inducible manner. Interference with the expression or the activity of PP5 leads to impairment of the ATR-mediated phosphorylation of hRad17 and Chk1 after UV or hydroxyurea treatment. Similar results are obtained in ATM-deficient cells, suggesting that the observed defect in checkpoint signaling is the consequence of impaired functional interaction between ATR and PP5. In cells exposed to UV irradiation, PP5 is required to elicit an appropriate S-phase checkpoint response. In addition, loss of PP5 leads to premature mitosis after hydroxyurea treatment. Interestingly, reduced PP5 activity exerts differential effects on the formation of intranuclear foci by ATR and replication protein A, implicating a functional role for PP5 in a specific stage of the checkpoint signaling pathway. Taken together, our results suggest that PP5 plays a critical role in the ATR-mediated checkpoint activation.
  • Zhang, Y., Ding, R., Frassinelli, D., Tuomainen, J., Klavinskis-Whiting, S., & Vigliocco, G. (2023). The role of multimodal cues in second language comprehension. Scientific Reports, 13: 20824. doi:10.1038/s41598-023-47643-2.

    Abstract

    In face-to-face communication, multimodal cues such as prosody, gestures, and mouth movements can play a crucial role in language processing. While several studies have addressed how these cues contribute to native (L1) language processing, their impact on non-native (L2) comprehension is largely unknown. Comprehension of naturalistic language by L2 comprehenders may be supported by the presence of (at least some) multimodal cues, as these provide correlated and convergent information that may aid linguistic processing. However, it is also the case that multimodal cues may be less used by L2 comprehenders because linguistic processing is more demanding than for L1 comprehenders, leaving more limited resources for the processing of multimodal cues. In this study, we investigated how L2 comprehenders use multimodal cues in naturalistic stimuli (while participants watched videos of a speaker), as measured by electrophysiological responses (N400) to words, and whether there are differences between L1 and L2 comprehenders. We found that prosody, gestures, and informative mouth movements each reduced the N400 in L2, indexing easier comprehension. Nevertheless, L2 participants showed weaker effects for each cue compared to L1 comprehenders, with the exception of meaningful gestures and informative mouth movements. These results show that L2 comprehenders focus on specific multimodal cues – meaningful gestures that support meaningful interpretation and mouth movements that enhance the acoustic signal – while using multimodal cues to a lesser extent than L1 comprehenders overall.

    Additional information

    supplementary materials
  • Wu, S., Zhao, J., de Villiers, J., Liu, X. L., Rolfhus, E., Sun, X. N., Li, X. Y., Pan, H., Wang, H. W., Zhu, Q., Dong, Y. Y., Zhang, Y. T., & Jiang, F. (2023). Prevalence, co-occurring difficulties, and risk factors of developmental language disorder: First evidence for Mandarin-speaking children in a population-based study. The Lancet Regional Health - Western Pacific, 34: 100713. doi:10.1016/j.lanwpc.2023.100713.

    Abstract

    Background: Developmental language disorder (DLD) is a condition that significantly affects children's achievement but has been understudied. We aim to estimate the prevalence of DLD in Shanghai, compare the co-occurrence of difficulties between children with DLD and those with typical development (TD), and investigate the early risk factors for DLD.

    Methods: We estimated DLD prevalence using data from a population-based survey with a cluster random sampling design in Shanghai, China. A subsample of children (aged 5-6 years) received an onsite evaluation, and each child was categorized as TD or DLD. The proportions of children with socio-emotional behavior (SEB) difficulties, low non-verbal IQ (NVIQ), and poor school readiness were calculated among children with TD and DLD. We used multiple imputation to address the missing values of risk factors. Univariate and multivariate regression models adjusted with sampling weights were used to estimate the correlation of each risk factor with DLD.

    Findings: Of 1082 children who were approached for the onsite evaluation, 974 (90.0%) completed the language ability assessments, of whom 74 met the criteria for DLD, resulting in a prevalence of 8.5% (95% CI 6.3-11.5) when adjusted with sampling weights. Compared with TD children, children with DLD had higher rates of concurrent difficulties, including SEB (total difficulties score at-risk: 156 [17.3%] of 900 TD vs. 28 [37.8%] of 74 DLD, p < 0.0001), low NVIQ (3 [0.3%] of 900 TD vs. 8 [10.8%] of 74 DLD, p < 0.0001), and poor school readiness (71 [7.9%] of 900 TD vs. 13 [17.6%] of 74 DLD, p = 0.0040). After accounting for all other risk factors, a higher risk of DLD was associated with a lack of parent-child interaction diversity (adjusted odds ratio [aOR] = 3.08, 95% CI = 1.29-7.37; p = 0.012) and lower kindergarten levels (compared to demonstration and first level: third level (aOR = 6.15, 95% CI = 1.92-19.63; p = 0.0020)).

    Interpretation: The prevalence of DLD and its co-occurrence with other difficulties suggest the need for further attention. Family and kindergarten factors were found to contribute to DLD, suggesting that multi-sector coordinated efforts are needed to better identify and serve DLD populations at home, in schools, and in clinical settings.

    Funding: The study was supported by Shanghai Municipal Education Commission (No. 2022you1-2, D1502), the Innovative Research Team of High-level Local Universities in Shanghai (No. SHSMU-ZDCX20211900), Shanghai Municipal Health Commission (No.GWV-10.1-XK07), and the National Key Research and Development Program of China (No. 2022YFC2705201).
  • Zioga, I., Weissbart, H., Lewis, A. G., Haegens, S., & Martin, A. E. (2023). Naturalistic spoken language comprehension is supported by alpha and beta oscillations. The Journal of Neuroscience, 43(20), 3718-3732. doi:10.1523/JNEUROSCI.1500-22.2023.

    Abstract

    Brain oscillations are prevalent in all species and are involved in numerous perceptual operations. α oscillations are thought to facilitate processing through the inhibition of task-irrelevant networks, while β oscillations are linked to the putative reactivation of content representations. Can the proposed functional role of α and β oscillations be generalized from low-level operations to higher-level cognitive processes? Here we address this question focusing on naturalistic spoken language comprehension. Twenty-two (18 female) Dutch native speakers listened to stories in Dutch and French while MEG was recorded. We used dependency parsing to identify three dependency states at each word: the number of (1) newly opened dependencies, (2) dependencies that remained open, and (3) resolved dependencies. We then constructed forward models to predict α and β power from the dependency features. Results showed that dependency features predict α and β power in language-related regions beyond low-level linguistic features. Left temporal, fundamental language regions are involved in language comprehension in α, while frontal and parietal, higher-order language regions, and motor regions are involved in β. Critically, α- and β-band dynamics seem to subserve language comprehension tapping into syntactic structure building and semantic composition by providing low-level mechanistic operations for inhibition and reactivation processes. Because of the temporal similarity of the α-β responses, their potential functional dissociation remains to be elucidated. Overall, this study sheds light on the role of α and β oscillations during naturalistic spoken language comprehension, providing evidence for the generalizability of these dynamics from perceptual to complex linguistic processes.
  • Zora, H., Wester, J. M., & Csépe, V. (2023). Predictions about prosody facilitate lexical access: Evidence from P50/N100 and MMN components. International Journal of Psychophysiology, 194: 112262. doi:10.1016/j.ijpsycho.2023.112262.

    Abstract

    Research into the neural foundation of perception asserts a model where top-down predictions modulate the bottom-up processing of sensory input. Despite becoming increasingly influential in cognitive neuroscience, the precise account of this predictive coding framework remains debated. In this study, we aim to contribute to this debate by investigating how predictions about prosody facilitate speech perception, and to shed light especially on lexical access influenced by simultaneous predictions in different domains, inter alia, prosodic and semantic. Using a passive auditory oddball paradigm, we examined neural responses to prosodic changes, leading to a semantic change as in Dutch nouns canon [ˈkaːnɔn] ‘cannon’ vs kanon [kaːˈnɔn] ‘canon’, and used acoustically identical pseudowords as controls. Results from twenty-eight native speakers of Dutch (age range 18–32 years) indicated an enhanced P50/N100 complex to prosodic change in pseudowords as well as an MMN response to both words and pseudowords. The enhanced P50/N100 response to pseudowords is claimed to indicate that all relevant auditory information is still processed by the brain, whereas the reduced response to words might reflect the suppression of information that has already been encoded. The MMN response to pseudowords and words, on the other hand, is best justified by the unification of previously established prosodic representations with sensory and semantic input respectively. This pattern of results is in line with the predictive coding framework acting on multiple levels and is of crucial importance to indicate that predictions about linguistic prosodic information are utilized by the brain as early as 50 ms.
  • Zormpa, E., Meyer, A. S., & Brehm, L. (2023). In conversation, answers are remembered better than the questions themselves. Journal of Experimental Psychology: Learning, Memory, and Cognition, 49(12), 1971-1988. doi:10.1037/xlm0001292.

    Abstract

    Language is used in communicative contexts to identify and successfully transmit new information that should be later remembered. In three studies, we used question–answer pairs, a naturalistic device for focusing information, to examine how properties of conversations inform later item memory. In Experiment 1, participants viewed three pictures while listening to a recorded question–answer exchange between two people about the locations of two of the displayed pictures. In a memory recognition test conducted online a day later, participants recognized the names of pictures that served as answers more accurately than the names of pictures that appeared as questions. This suggests that this type of focus indeed boosts memory. In Experiment 2, participants listened to the same items embedded in declarative sentences. There was a reduced memory benefit for the second item, confirming the role of linguistic focus on later memory beyond a simple serial-position effect. In Experiment 3, two participants asked and answered the same questions about objects in a dialogue. Here, answers continued to receive a memory benefit, and this focus effect was accentuated by language production such that information-seekers remembered the answers to their questions better than information-givers remembered the questions they had been asked. Combined, these studies show how people’s memory for conversation is modulated by the referential status of the items mentioned and by the speaker’s roles of the conversation participants.

Share this page