Publications

Abstract

Importance Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities.

Objective To determine the association of the 15q11.2 BP1-BP2 deletion and duplication CNVs with cortical and subcortical brain morphology and cognitive task performance.

Design, Setting, and Participants In this genetic association study, T1-weighted brain magnetic resonance imaging were combined with genetic data from the ENIGMA-CNV consortium and the UK Biobank, with a replication cohort from Iceland. In total, 203 deletion carriers, 45 247 noncarriers, and 306 duplication carriers were included. Data were collected from August 2015 to April 2019, and data were analyzed from September 2018 to September 2019.

Main Outcomes and Measures The associations of the CNV with global and regional measures of surface area and cortical thickness as well as subcortical volumes were investigated, correcting for age, age2, sex, scanner, and intracranial volume. Additionally, measures of cognitive ability were analyzed in the full UK Biobank cohort.

Results Of 45 756 included individuals, the mean (SD) age was 55.8 (18.3) years, and 23 754 (51.9%) were female. Compared with noncarriers, deletion carriers had a lower surface area (Cohen d = −0.41; SE, 0.08; P = 4.9 × 10−8), thicker cortex (Cohen d = 0.36; SE, 0.07; P = 1.3 × 10−7), and a smaller nucleus accumbens (Cohen d = −0.27; SE, 0.07; P = 7.3 × 10−5). There was also a significant negative dose response on cortical thickness (β = −0.24; SE, 0.05; P = 6.8 × 10−7). Regional cortical analyses showed a localization of the effects to the frontal, cingulate, and parietal lobes. Further, cognitive ability was lower for deletion carriers compared with noncarriers on 5 of 7 tasks.

Conclusions and Relevance These findings, from the largest CNV neuroimaging study to date, provide evidence that 15q11.2 BP1-BP2 structural variation is associated with brain morphology and cognition, with deletion carriers being particularly affected. The pattern of results fits with known molecular functions of genes in the 15q11.2 BP1-BP2 region and suggests involvement of these genes in neuronal plasticity. These neurobiological effects likely contribute to the association of this CNV with neurodevelopmental disorders.

Abstract

The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are differentially involved in memory consolidation, spatial navigation and pattern separation, complex functions often impaired in individuals with brain disorders characterized by reduced hippocampal volume, including Alzheimer’s disease (AD) and schizophrenia. Given the structural and functional heterogeneity of the hippocampal formation, we sought to characterize the subfields’ genetic architecture. T1-weighted brain scans (n = 21,297, 16 cohorts) were processed with the hippocampal subfields algorithm in FreeSurfer v6.0. We ran a genome-wide association analysis on each subfield, co-varying for whole hippocampal volume. We further calculated the single-nucleotide polymorphism (SNP)-based heritability of 12 subfields, as well as their genetic correlation with each other, with other structural brain features and with AD and schizophrenia. All outcome measures were corrected for age, sex and intracranial volume. We found 15 unique genome-wide significant loci across six subfields, of which eight had not been previously linked to the hippocampus. Top SNPs were mapped to genes associated with neuronal differentiation, locomotor behaviour, schizophrenia and AD. The volumes of all the subfields were estimated to be heritable (h2 from 0.14 to 0.27, all p < 1 × 10–16) and clustered together based on their genetic correlations compared with other structural brain features. There was also evidence of genetic overlap of subicular subfield volumes with schizophrenia. We conclude that hippocampal subfields have partly distinct genetic determinants associated with specific biological processes and traits. Taking into account this specificity may increase our understanding of hippocampal neurobiology and associated pathologies.

Abstract

How can people communicate successfully while keeping resource costs low in the face of ambiguity? We present a principled theoretical analysis comparing two strategies for disambiguation in communication: (i) pragmatic reasoning, where communicators reason about each other, and (ii) other-initiated repair, where communicators signal and resolve trouble interactively. Using agent-based simulations and computational complexity analyses, we compare the efficiency of these strategies in terms of communicative success, computation cost and interaction cost. We show that agents with a simple repair mechanism can increase efficiency, compared to pragmatic agents, by reducing their computational burden at the cost of longer interactions. We also find that efficiency is highly contingent on the mechanism, highlighting the importance of explicit formalisation and computational rigour.

Abstract

In this paper we investigate acoustic differences between vowels in syllables that do or do not carry lexical stress. In doing so, we concentrated on segmental acoustic phonetic features that are conventionally assumed to differ between stressed and unstressed syllables, viz. Duration, Energy and Spectral Tilt. The speech material in this study differs from the type of material used in previous research: instead of specially constructed sentences we used phonetically rich sentences from the Dutch POLYPHONE corpus. Most of the Duration, Energy and Spectral Tilt features that we used in the investigation show statistically significant differences for the population means of stressed and unstressed vowels. However, it also appears that the distributions overlap to such an extent that automatic detection of stressed and unstressed syllables yields correct classifications of 72.6% at best. It is argued that this result is due to the large variety in the ways in which the abstract linguistic feature `lexical stress' is realized in the acoustic speech signal. Our findings suggest that a lexical stress detector has little use for a single pass decoder in an automatic speech recognition (ASR) system, but could still play a useful role as an additional knowledge source in a multi-pass decoder.

Abstract

An essential phenomenon in the development towards syntactic maturity after early childhood is the increasing use of so-called sentence-combining transformations. Especially by using subordination, complex sentences are produced. The research reported here is an attempt to arrive at a more adequate characterization and explanation. Our starting point was an analysis of 280 texts written by Dutch-speaking pupils of the two highest grades of the primary school and the four lowest grades of three different types of secondary education. It was examined whether systematic shifts in the use of certain groups of so-called function words could be traced. We concluded that the development of the syntactic formulating ability can be characterized as an increase in connectivity: the use of all kinds of function words which explicitly mark logico-semantic relations between propositions. This development starts by inserting special adverbs and coordinating conjunctions resulting in various types of coordination. In a later stage, the syntactic patterning of the sentence is affected as well (various types of subordination). The increase in sentence complexity is only one aspect of the entire development. An explanation for the increase in connectivity is offered based upon a distinction between narrative and expository language use. The latter, but not the former, is characterized by frequent occurrence of connectives. The development in syntactic formulating ability includes a high level of skill in expository language use. Speed of development is determined by intensity of training, e.g. in scholastic and occupational settings.

Abstract

An event-related brain potentials experiment was carried out to examine the interplay of referential and structural factors during sentence processing in discourse. Subjects read (Dutch) sentences beginning like “David told the girl that … ” in short story contexts that had introduced either one or two referents for a critical singular noun phrase (“the girl”). The waveforms showed that within 280 ms after onset of the critical noun the reader had already determined whether the noun phrase had a unique referent in earlier discourse. Furthermore, this referential information was immediately used in parsing the rest of the sentence, which was briefly ambiguous between a complement clause (“ … that there would be some visitors”) and a relative clause (“ … that had been on the phone to hang up”). A consistent pattern of P600/SPS effects elicited by various subsequent disambiguations revealed that a two-referent discourse context had led the parser to initially pursue the relative-clause alternative to a larger extent than a one-referent context. Together, the results suggest that during the processing of sentences in discourse, structural and referential sources of information interact on a word-by-word basis.

Abstract

An introductory study of the perception of stochastically specified events is reported. The initial problem was to determine whether the perceiver can split visual input data of this kind into random and determined components. The inability of subjects to do so with the stimulus material used (a filmlike sequence of dot patterns), led to the more general question of how subjects code this kind of visual material. To meet the difficulty of defining the subjects' responses, two experiments were designed. In both, patterns were presented as a rapid sequence of dots on a screen. The patterns were more or less disturbed by “noise,” i.e. the dots did not appear exactly at their proper places. In the first experiment the response was a rating on a semantic scale, in the second an identification from among a set of alternative patterns. The results of these experiments give some insight in the coding systems adopted by the subjects. First, noise appears to be detrimental to pattern recognition, especially to patterns with little spread. Second, this shows connections with the factors obtained from analysis of the semantic ratings, e.g. easily disturbed patterns show a large drop in the semantic regularity factor, when only a little noise is added.

Abstract

Three cross-modal priming experiments examined the role of suprasegmental information in the processing of spoken words. All primes consisted of truncated spoken Dutch words. Recognition of visually presented word targets was facilitated by prior auditory presentation of the first two syllables of the same words as primes, but only if they were appropriately stressed (e.g., OKTOBER preceded by okTO-); inappropriate stress, compatible with another word (e.g., OKTOBER preceded by OCto-, the beginning of octopus), produced inhibition. Monosyllabic fragments (e.g., OC-) also produced facilitation when appropriately stressed; if inappropriately stressed, they produced neither facilitation nor inhibition. The bisyllabic fragments that were compatible with only one word produced facilitation to semantically associated words, but inappropriate stress caused no inhibition of associates. The results are explained within a model of spoken-word recognition involving competition between simultaneously activated phonological representations followed by activation of separate conceptual representations for strongly supported lexical candidates; at the level of the phonological representations, activation is modulated by both segmental and suprasegmental information.

Abstract

The authors examined whether people can use their knowledge of the wider discourse rapidly enough to anticipate specific upcoming words as a sentence is unfolding. In an event-related brain potential (ERP) experiment, subjects heard Dutch stories that supported the prediction of a specific noun. To probe whether this noun was anticipated at a preceding indefinite article, stories were continued with a gender-marked adjective whose suffix mismatched the upcoming noun's syntactic gender. Prediction-inconsistent adjectives elicited a differential ERP effect, which disappeared in a no-discourse control experiment. Furthermore, in self-paced reading, prediction-inconsistent adjectives slowed readers down before the noun. These findings suggest that people can indeed predict upcoming words in fluent discourse and, moreover, that these predicted words can immediately begin to participate in incremental parsing operations.

Abstract

Earlier research has shown that established authors can be distinguished by measuring specific properties of their writings, their stylome as it were. Here, we examine writings of less experienced authors. We succeed in distinguishing between these authors with a very high probability, which implies that a stylome exists even in the general population. However, the number of traits needed for so successful a distinction is an order of magnitude larger than assumed so far. Furthermore, traits referring to syntactic patterns prove less distinctive than traits referring to vocabulary, but much more distinctive than expected on the basis of current generativist theories of language learning.

Abstract

We report a series of experiments examining the effects on word processing of insertion of an optional epenthetic vowel in word-final consonant clusters in Dutch. Such epenthesis turns film, for instance, into film. In a word-reversal task listeners treated words with and without epenthesis alike, as monosyllables, suggesting that the variant forms both activate the same canonical representation, that of a monosyllabic word without epenthesis. In both lexical decision and word spotting, response times to recognize words were significantly faster when epenthesis was present than when the word was presented in its canonical form without epenthesis. It is argued that addition of the epenthetic vowel makes the liquid consonants constituting the first member of a cluster more perceptible; a final phoneme-detection experiment confirmed that this was the case. These findings show that a transformed variant of a word, although it contacts the lexicon via the representation of the canonical form, can be more easily perceptible than that canonical form.

Abstract

Fluency is an important part of research on second language learning, but most research on language proficiency typically has not included oral fluency as part of interaction, even though natural communication usually occurs in conversations. The present study considered aspects of turn-taking behavior as part of the construct of fluency and investigated whether these aspects differentially influence perceived fluency ratings of native and non-native speech. Results from two experiments using acoustically manipulated speech showed that, in native speech, too ‘eager’ (interrupting a question with a fast answer) and too ‘reluctant’ answers (answering slowly after a long turn gap) negatively affected fluency ratings. However, in non-native speech, only too ‘reluctant’ answers led to lower fluency ratings. Thus, we demonstrate that acoustic properties of dialogue are perceived as part of fluency. By adding to our current understanding of dialogue fluency, these lab-based findings carry implications for language teaching and assessment

Abstract

Investigating phenotypic heterogeneity in aggression and understanding the molecular biological basis of aggression subtypes may lead to new prevention and treatment options. In the current study, we evaluated the taxonomy of aggression and examined specific genetic mechanisms underlying aggression subtypes in healthy males and females. Confirmatory Factor Analysis (CFA) was used to replicate a recently reported three-factor model of the Reactive Proactive Questionnaire (RPQ) in healthy adults (n=661; median age 24.0 years; 41% male). Gene-set association analysis, aggregating common genetic variants within (a combination of) three molecular pathways previously implicated in aggression, i.e. serotonergic, dopaminergic, and neuroendocrine signaling, was conducted with MAGMA software in males and females separately (total n=395) for aggression subtypes. We replicate the three-factor CFA model of the RPQ, and found males to score significantly higher on one of these factors compared to females: proactive aggression. The genetic association analysis showed a female-specific association of genetic variation in the combined gene-set with a different factor of the RPQ; reactive aggression due to internal frustration. Both the neuroendocrine and serotonergic gene-sets contributed significantly to this association. Our genetic findings are subtype- and sex-specific, stressing the value of efforts to reduce heterogeneity in research of aggression etiology. Importantly, subtype- and sex-differences in the underlying pathophysiology of aggression suggest that optimal treatment options will have to be tailored to the individual patient. Male and female needs of intervention might differ, stressing the need for sex-specific further research of aggression. Our work highlights opportunities for sample size maximization offered by population-based studies of aggression.

Abstract

Language is a system of communication in which grammatical structures function to express meaning in context. While all languages can achieve the same basic communicative ends, they each use different means to achieve them, particularly in the divergent ways that syntax, semantics and pragmatics interact across languages. This book looks in detail at how structure, meaning, and communicative function interact in human languages. Working within the framework of Role and Reference Grammar (RRG), Van Valin proposes a set of rules, called the ‘linking algorithm’, which relates syntactic and semantic representations to each other, with discourse-pragmatics playing a role in the linking. Using this model, he discusses the full range of grammatical phenomena, including the structures of simple and complex sentences, verb and argument structure, voice, reflexivization and extraction restrictions. Clearly written and comprehensive, this book will be welcomed by all those working on the interface between syntax, semantics and pragmatics.

Abstract

As a preliminary to further research on musical consonance an explanatory investigation was made on the different modes of judgment of musical intervals. This was done by way of a semantic differential. Subjects rated 23 intervals against 10 scales. In a factor analysis three factors appeared: pitch, evaluation and fusion. The relation between these factors and some physical characteristics has been investigated. The scale consonant-dissonant showed to be purely evaluative (in opposition to Stumpf's theory). This evaluative connotation is not in accordance with the musicological meaning of consonance. Suggestions to account for this difference have been given.

Abstract

Meermalen is getracht om syntactische formuleenuuirdigheid direct en objectief te meten aan de hand van gesproken of geschreven teksten. Uitgangspunt hierbij vormde in de regel de syntactische complexiteit van de geproduceerde taaluitingen. Dit heeft echter niet geleid tot een plausibele, duidelijk omschreven en praktisch bruikbare index. N.a.v. een kritische bespreking van de notie complexiteit wordt in dit artikel als nieuw criterium voorgesteld de connectiviteit van de taaluitingen; de expliciete aanduiding van logiscli-scmantische relaties tussen proposities. Connectiviteit is gemakkelijk scoorbaar aan de hand van functiewoorden die verschillende vormen van nevenschikkend en onderschikkend zinsverband markeren. Deze nieuwe index ondetrangt de kritiek die op complexiteit gegeven kon worden, blijkt duidelijk te discrimineren tussen groepen leerlingen die van elkaar verschillen naar leeftijd en opleidingsniveau, en sluit aan bij recente taalpsychologische en sociolinguïstische theorie. Tot besluit worden enige onderwijskundige implicaties aangegeven.

Abstract

In two ERP experiments we investigated how and when the language comprehension system relates an incoming word to semantic representations of an unfolding local sentence and a wider discourse. In experiment 1, subjects were presented with short stories. The last sentence of these stories occasionally contained a critical word that, although acceptable in the local sentence context, was semantically anomalous with respect to the wider discourse (e.g., "Jane told the brother that he was exceptionally slow" in a discourse context where he had in fact been very quick). Relative to coherent control words (e.g., "quick"), these discourse-dependent semantic anomalies elicited a large N400 effect that began at about 200-250 ms after word onset. In experiment 2, the same sentences were presented without their original story context. Although the words that had previously been anomalous in discourse still elicited a slightly larger average N400 than the coherent words, the resulting N400 effect was much reduced, showing that the large effect observed in stories was related to the wider discourse. In the same experiment, single sentences that contained a clear local semantic anomaly elicited a standard sentence-dependent N400 effect (e.g., Kutas & Hillyard, 1980). The N400 effects elicited in discourse and in single sentences had the same time course, overall morphology, and scalp distribution. We argue that these findings are most compatible with models of language processing in which there is no fundamental distinction between the integration of a word in its local (sentence-level) and its global (discourse-level) semantic context.

Abstract

We review the implications of recent ERP evidence for when and how grammatical gender agreement constrains sentence parsing. In some theories of parsing, gender is assumed to immediately and categorically block gender-incongruent phrase structure alternatives from being pursued. In other theories, the parser initially ignores gender altogether. The ERP evidence we discuss suggests an intermediate position, in which grammatical gender does not immediately block gender-incongruent phrase structures from being considered, but is used to dispose of them shortly thereafter.

Abstract

Motor-related brain potentials were used to examine the time course of grammatical and phonological processes during noun phrase production in Dutch. In the experiments, participants named colored pictures using a no-determiner noun phrase. On half of the trials a syntactic-phonological classification task had to be performed before naming. Depending on the outcome of the classifications, a left or a right push-button response was given (go trials), or no push-button response was given (no-go trials). Lateralized readiness potentials (LRPs) were derived to test whether syntactic and phonological information affected the motor system at separate moments in time. The results showed that when syntactic information determined the response-hand decision, an LRP developed on no-go trials. However, no such effect was observed when phonological information determined response hand. On the basis of the data, it can be estimated that an additional period of at least 40 ms is needed to retrieve a word's initial phoneme once its lemma has been retrieved. These results provide evidence for the view that during speaking, grammatical processing precedes phonological processing in time.

Abstract

To test the BIA+ and Multilink models’ accounts of how bilinguals process words with different degrees of cross-linguistic orthographic and semantic overlap, we conducted two experiments manipulating stimulus list composition. Dutch-English late bilinguals performed two English lexical decision tasks including the same set of cognates, interlingual homographs, English control words, and pseudowords. In one task, half of the pseudowords were replaced with Dutch words, requiring a ‘no’ response. This change from pure to mixed language list context was found to turn cognate facilitation effects into inhibition. Relative to control words, larger effects were found for cognate pairs with an increasing cross-linguistic form overlap. Identical cognates produced considerably larger effects than non-identical cognates, supporting their special status in the bilingual lexicon. Response patterns for different item types are accounted for in terms of the items’ lexical representation and their binding to ‘yes’ and ‘no’ responses in pure vs mixed lexical decision.

Abstract

An ongoing debate in the speech production literature suggests that the initial building block to build up speech sounds differs between languages. That is, Germanic languages are suggested to use the phoneme, but Japanese and Chinese are proposed to use the mora or syllable, respectively. Several studies investigated this matter from a chronometric perspective (i.e., RTs and accuracy). However, a less attention has been paid to the actual acoustic utterances. The current study investigated the verbal responses of two Japanese-English bilingual groups of different proficiency levels (i.e., high and low) when naming English words and found that the presence or absence of vowel epenthesis depended on proficiency. The results indicate that: (1) English word pronunciation by low-proficient Japanese English bilinguals is likely based on their L1 (Japanese) building block and (2) that future studies would benefit from analyzing the acoustic data as well when making inferences from chronometric data.

Abstract

The acquisition of non-modal auxiliaries has been assumed to constitute an important step in the acquisition of finiteness in Germanic languages (cf. Jordens/Dimroth 2005, Jordens 2004, Becker 2005). This paper focuses onthe role of the auxiliary hebben (>to have<) in the acquisition of Dutch as a second language. More specifically, it investigates whether learners' production of hebben is related to their acquisition of two phenomena commonly associated with finiteness, i.e., topicalization and negation. Data are presented from 16 Turkish and 36 Moroccan learners of Dutch who participated in an experiment involving production and imitation tasks. The production data suggest that learners use topicalization and post-verbal negation only after they have learned to produce the auxiliary hebben. The results from the imitation task indicate, that learners are more sensitive to topicalization and post-verbal negation in sentences with hebben than in sentences with lexical verbs. Interestingly this holds also for learners that did not show productive command of hebben in the production tasks. Thus, in general, the results of the experiment provide support for the idea that non-modal auxiliaries are crucial in the acquisition of (certain properties of) finiteness.

Abstract

Congenital disorders of glycosylation (CDG) are a group of clinically and genetically heterogeneous metabolic disorders. Over 150 CDG types have been described. Most CDG types are ultrarare disorders. CDG types affecting N-glycosylation are the most common type of CDG with emerging therapeutic possibilities. This review is an update on the available therapies for disorders affecting the N-linked glycosylation pathway. In the first part of the review, we highlight the clinical presentation, general principles of management, and disease-specific therapies for N-linked glycosylation CDG types, organized by organ system. The second part of the review focuses on the therapeutic strategies currently available and under development. We summarize the successful (pre-) clinical application of nutritional therapies, transplantation, activated sugars, gene therapy, and pharmacological chaperones and outline the anticipated expansion of the therapeutic possibilities in CDG. We aim to provide a comprehensive update on the treatable aspects of CDG types involving N-linked glycosylation, with particular emphasis on disease-specific treatment options for the involved organ systems; call for natural history studies; and present current and future therapeutic strategies for CDG.

Abstract

The comparative approach can provide insight into the evolution of human speech, language and social communication by studying relevant traits in animal systems. Bats are emerging as a model system with great potential to shed light on these processes given their learned vocalizations, close social interactions, and mammalian brains and physiology. A recent framework outlined the multiple levels of investigation needed to understand vocal learning across a broad range of non-human species, including cetaceans, pinnipeds, elephants, birds and bats. Here, we apply this framework to the current state-of-the-art in bat research. This encompasses our understanding of the abilities bats have displayed for vocal learning, what is known about the timing and social structure needed for such learning, and current knowledge about the prevalence of the trait across the order. It also addresses the biology (vocal tract morphology, neurobiology and genetics) and evolution of this trait. We conclude by highlighting some key questions that should be answered to advance our understanding of the biological encoding and evolution of speech and spoken communication. This article is part of the theme issue 'What can animal communication teach us about human language?'

Abstract

A controversial issue in psycholinguistics is the degree to which speakers employ audience design during language production. Hypothesising that a consideration of the listener’s needs is particularly relevant when the listener is under cognitive load, we had speakers describe objects for a listener performing an easy or a difficult simulated driving task. We predicted that speakers would introduce more redundancy in their descriptions in the difficult driving task, thereby accommodating the listener’s reduced cognitive capacity. The results showed that speakers did not adapt their descriptions to a change in the listener’s cognitive load. However, speakers who had experienced the driving task themselves before and who were presented with the difficult driving task first were more redundant than other speakers. These findings may suggest that speakers only consider the listener’s needs in the presence of strong enough cues, and do not update their beliefs about these needs during the task.

Abstract

We investigated whether the language of instruction (Dutch or English) influenced the study success of 614 Dutch and German first-year psychology students in the Netherlands. The Dutch students who were instructed in Dutch studied in their native language (L1), the other students in a second language (L2). In addition, only the Dutch students studied in their home country. Both these variables could potentially influence study success, operationalised as the number of European Credits (ECs) the students obtained, their grades, and drop-out rates. The L1 group outperformed the three L2 groups with respect to grades, but there were no significant differences in ECs and drop-out rates (although descriptively, the L1 group still performed best). In conclusion, this study shows an advantage of studying in the L1 when it comes to grades, and thereby contributes to the current debate in the Dutch media regarding the desirability of offering degrees taught in English.

Abstract

Processing of cataphoric coreferential relationships.

Abstract

Tzeltal, a Mayan language spoken in southern Mexico, exhibits allo-morphy of an unusual type. The vowel quality of the perfective suffix is determined by the number of syllables in the stem to which it is attaching. This paper presents previously unpublished data of this allomorphy and demonstrates that a syllable-count analysis of the phenomenon is the proper one. This finding is put in a more general context of segment-prosody interaction in allomorphy.

Abstract

We report detailed analyses of a very large database on timing of speech perception collected by Smits et al. (Smits, R., Warner, N., McQueen, J.M., Cutler, A., 2003. Unfolding of phonetic information over time: A database of Dutch diphone perception. J. Acoust. Soc. Am. 113, 563–574). Eighteen listeners heard all possible diphones of Dutch, gated in portions of varying size and presented without background noise. The present report analyzes listeners’ responses across gates in terms of phonological features (voicing, place, and manner for consonants; height, backness, and length for vowels). The resulting patterns for feature perception differ from patterns reported when speech is presented in noise. The data are also analyzed for effects of stress and of phonological context (neighboring vowel vs. consonant); effects of these factors are observed to be surprisingly limited. Finally, statistical effects, such as overall phoneme frequency and transitional probabilities, along with response biases, are examined; these too exercise only limited effects on response patterns. The results suggest highly accurate speech perception on the basis of acoustic information alone.

Abstract

Korean has a very complex phonology, with many interacting alternations. In a coronal-/i/ sequence, depending on the type of phonological boundary present, alternations such as palatalization, nasal insertion, nasal assimilation, coda neutralization, and intervocalic voicing can apply. This paper investigates how the phonological patterns of Korean affect processing of morphemes and words. Past research on languages such as English, German, Dutch, and Finnish has shown that listeners exploit syllable structure constraints in processing speech and segmenting it into words. The current study shows that in parsing speech, listeners also use much more complex patterns that relate the surface phonological string to various boundaries.

Abstract

An event-related brain potential experiment was carried out to investigate on-line syntactic processing in patients with Broca’s aphasia. Subjects were visually presented with sentences that were either syntactically correct or contained violations of word-category. Three groups of subjects were tested: Broca patients (N=11), non-aphasic patients with a right hemisphere (RH) lesion (N=9), and healthy aged-matched controls (N=15). Both control groups appeared sensitive to the violations of word-category as shown by clear P600/SPS effects. The Broca patients displayed only a very reduced and delayed P600/SPS effect. The results are discussed in the context of a lexicalist parsing model. It is concluded that Broca patients are hindered to detect on-line violations of word-category, if word class information is incomplete or delayed available.

Abstract

This dissertation focuses on syntactic comprehension problems in patients with Broca's aphasia from an electrophysiological perspective. The central objective of this dissertation was to further explore what syntax-related event-related brain potential (ERP) effects can reveal about the nature of the deficit that underlies syntactic comprehension problems in patients with Broca's aphasia. Chapter two to four describe experiments in which event-related brain potentials were recorded while subjects (Broca patients, non-aphasic patients with a right-hemisphere lesion, and healthy elderly controls) were presented with sentences that contained either violations of syntactic constraints or were syntactically correct. Chapter two investigates ERP effects of subject-verb agreement violations in the different subject groups, and seeks to answer the following questions: Do agrammatic comprehenders show sensitivity to subject-verb agreement violations as indicated by a syntax-related ERP effect? In addition, does the severity of the syntactic comprehension impairment in the Broca patients affect the ERP responses? Chapter three describes an investigation of whether Broca patients show sensitivity to violations of word order as indicated by a syntax-related ERP effect, and whether the ERP responses in the Broca patients are affected by the severity of their syntactic comprehension impairment. Chapter four reports on ERP effects of violations of word-category. In addition, also a semantic violation condition was added to track possible dissociations in the sensitivity to semantic and syntactic information in the Broca patients. Chapter five describes the development of a paradigm in which the electrophysiological approach and the classical sentence-picture matching approach are combined. In this chapter, the ERP method is applied to study on-line thematic role assignment in Broca patients during sentence-picture matching. Also the relation between ERP effects and behavioral responses is pursued. Finally, Chapter 6 provides a summary of the main findings of the experiments and a general discussion.

Abstract

Margulies et al. (2016) demonstrated the existence of at least five independent functional connectivity gradients in the human brain. However, it is unclear how these functional gradients might link to anatomy. The dual origin theory proposes that differences in cortical cytoarchitecture originate from two trends of progressive differentiation between the different layers of the cortex, referred to as the hippocampocentric and olfactocentric systems. When conceptualising the functional connectivity gradients within the evolutionary framework of the Dual Origin theory, the first gradient likely represents the hippocampocentric system anatomically. Here we expand on this concept and demonstrate that the fifth gradient likely links to the olfactocentric system. We describe the anatomy of the latter as well as the evidence to support this hypothesis. Together, the first and fifth gradients might help to model the Dual Origin theory of the human brain and inform brain models and pathologies.

Abstract

Speech comprehension requires rapid online processing of a continuous acoustic signal to extract structure and meaning. Previous studies on sentence comprehension have found neural correlates of the predictability of a word given its context, as well as of the precision of such a prediction. However, they have focused on single sentences and on particular words in those sentences. Moreover, they compared neural responses to words with low and high predictability, as well as with low and high precision. However, in speech comprehension, a listener hears many successive words whose predictability and precision vary over a large range. Here, we show that cortical activity in different frequency bands tracks word surprisal in continuous natural speech and that this tracking is modulated by precision. We obtain these results through quantifying surprisal and precision from naturalistic speech using a deep neural network and through relating these speech features to EEG responses of human volunteers acquired during auditory story comprehension. We find significant cortical tracking of surprisal at low frequencies, including the delta band as well as in the higher frequency beta and gamma bands, and observe that the tracking is modulated by the precision. Our results pave the way to further investigate the neurobiology of natural speech comprehension.

Abstract

How do languages express ideas of movement, and how do they package features that can be part of motion, such as path and cause? This questionnaire is used to gain a picture of the lexical resources a language draws on for motion expressions. It targets issues of semantic conflation (i.e., what other semantic information besides motion may be encoded in a verb root) and patterns of semantic distribution (i.e., what types of information are encoded in the morphemes that come together to build a description of a motion event). It was originally designed for Australian languages, but has since been used around the world.

Abstract

Contrastive reference, where a speaker presents or identifies one item in explicit contrast to another (I like this book but that one is boring), has special communicative and information structure properties. This can be reflected in rules of demonstrative use. For example, in some languages, terms equivalent to this and that can be used for contrastive reference in almost any spatial context. But other two-term languages stick more closely to “distance rules” for demonstratives, allowing a this-like term in close space only. This task elicits data concerning one context of contrastive reference, focusing on whether (and how) non-proximal demonstratives can be used to distinguish objects within a proximal area. The task runs like a memory game, with the consultant being asked to identify the locations of two or three hidden items arranged within arm’s reach.

Abstract

Demonstrative terms (e.g., this and that) are key to understanding how a language constructs and interprets spatial relationships. They are tricky to pin down, typically having functions that do not match “idealized” uses, and that can become invisible in narrow elicitation settings. This questionnaire is designed to identify the range(s) of use of certain spatial demonstrative terms, and help assess the roles played by gesture, access, attention, and addressee knowledge in demonstrative use. The stimuli consist of 25 diagrammed “elicitation settings” to be created by the researcher.

Abstract

People organize and convey their thoughts according to narratives. However, neuroscientists are often reluctant to incorporate narrative stimuli into their experiments. We argue that narratives deserve wider adoption in human neuroscience because they tap into the brain’s native machinery for representing the world and provide rich variability for testing hypotheses.

Abstract

Learning and processing natural language requires the ability to track syntactic relationships between words and phrases in a sentence, which are often separated by intervening material. These nonadjacent dependencies can be studied using artificial grammar learning paradigms and structured sequence processing tasks. These approaches have been used to demonstrate that human adults, infants and some nonhuman animals are able to detect and learn dependencies between nonadjacent elements within a sequence. However, learning nonadjacent dependencies appears to be more cognitively demanding than detecting dependencies between adjacent elements, and only occurs in certain circumstances. In this review, we discuss different types of nonadjacent dependencies in language and in artificial grammar learning experiments, and how these differences might impact learning. We summarize different types of perceptual cues that facilitate learning, by highlighting the relationship between dependent elements bringing them closer together either physically, attentionally, or perceptually. Finally, we review artificial grammar learning experiments in human adults, infants, and nonhuman animals, and discuss how similarities and differences observed across these groups can provide insights into how language is learned across development and how these language‐related abilities might have evolved.

Abstract

Angelika Wittek untersuchte Zustandsveränderungsverben bei vier- bis sechsjährigen Kindern. Englischsprechende Kinder verstehen bis zum Alter von 8 Jahren diese Verben als Bewegungsverben und ignorieren, daß sie zusätzlich die Information über einen Endzustand im Sinne der Negation des Ausgangszustands beeinhalten. Wittek zeigte, daß entgegen der Erwartung transparente, morphologisch komplexe Formen (wachmachen), in denen die Partikel den Endzustand explizit macht, nicht besser verstanden werden als Simplizia (wecken). Zudem diskutierte sie, inwieweit die Verwendung des Adverbs wieder in restitutiver Lesart Hinweise auf den Erwerb dieser Verben geben kann.

Abstract

Institutions driving fundamental research at the cutting edge such as for example from the Max Planck Society (MPS) took steps to optimize data management and stewardship to be able to address new scientific questions. In this paper we selected three institutes from the MPS from the areas of humanities, environmental sciences and natural sciences as examples to indicate the efforts to integrate large amounts of data from collaborators worldwide to create a data space that is ready to be exploited to get new insights based on data intensive science methods. For this integration the typical challenges of fragmentation, bad quality and also social differences had to be overcome. In all three cases, well-managed repositories that are driven by the scientific needs and harmonization principles that have been agreed upon in the community were the core pillars. It is not surprising that these principles are very much aligned with what have now become the FAIR principles. The FAIR principles confirm the correctness of earlier decisions and their clear formulation identified the gaps which the projects need to address.

Abstract

About 5,000 languages are spoken in the world today. More than half of them have less than 10,000 speakers, a quarter of them even fewer than 1,000. The majority of these “small” languages will not live to see the end of this century; some estimates predict that no more than a dozen languages will still be spoken by the turn of the next millennium. This collection of papers approaches the subject of language extinction through five major topics: general aspects of language death, case studies, endangered subsystems, language protection and revitalization, language ecology. In 24 articles, the authors address the causes, manifestations, and consequences of language endangerment and extinction as well as the linguistic and social changes associated with it, drawing examples from a large number of languages.

Abstract

Previous studies suggest that bilinguals' lexical access is language non-selective, especially for orthographically identical translation equivalents across languages (i.e., identical cognates). The present study investigated how such words (e.g., meaning "school" in both Chinese and Japanese) are processed in the (late) Chinese - Japanese bilingual brain. Using an L2-Japanese lexical decision task, both behavioral and electrophysiological data were collected. Reaction times (RTs), as well as the N400 component, showed that cognates are more easily recognized than non-cognates. Additionally, an early component (i.e., the N250), potentially reflecting activation at the word-form level, was also found. Cognates elicited a more positive N250 than non-cognates in the frontal region, indicating that the cognate facilitation effect occurred at an early stage of word formation for languages with logographic scripts.

Abstract

Language users process utterances by segmenting them into many cognitive units, which vary in their sizes and linguistic levels. Although we can do such unitization/segmentation easily, its cognitive mechanism is still not clear. This paper proposes an unsupervised model, Less-is-Better (LiB), to simulate the human cognitive process with respect to language unitization/segmentation. LiB follows the principle of least effort and aims to build a lexicon which minimizes the number of unit tokens (alleviating the effort of analysis) and number of unit types (alleviating the effort of storage) at the same time on any given corpus. LiB’s workflow is inspired by empirical cognitive phenomena. The design makes the mechanism of LiB cognitively plausible and the computational requirement light-weight. The lexicon generated by LiB performs the best among different types of lexicons (e.g. ground-truth words) both from an information-theoretical view and a cognitive view, which suggests that the LiB lexicon may be a plausible proxy of the mental lexicon.

Abstract

A core question in language acquisition is whether children’s syntactic processing is experience-dependent and language-specific, or whether it is governed by abstract, universal syntactic machinery. We address this question by presenting corpus and on-line processing dat a from children learning Mandarin Chinese, a language that has been important in debates about the universality of parsing processes. The corpus data revealed that two different relative clause constructions in Mandarin are differentially used to modify syntactic subjects and objects. In the experiment, 4-year-old children’s eye-movements were recorded as they listened to the two RC construction types (e.g., Can you pick up the pig that pushed the sheep?). A permutation analysis showed that children’s ease of comprehension was closely aligned with the distributional frequencies, suggesting syntactic processing preferences are shaped by the input experience of these constructions.

Abstract

Chunking in language comprehension is a process that segments continuous linguistic input into smaller chunks that are in the reader’s mental lexicon. Effective chunking during reading facilitates disambiguation and enhances efficiency for comprehension. However, the chunking mechanisms remain elusive, especially in reading given that information arrives simultaneously yet the written systems may not have explicit cues for labeling boundaries such as Chinese. What are the mechanisms of chunking that mediates the reading of the text that contains hierarchical information? We investigated this question by manipulating the lexical status of the chunks at distinct levels in four-character Chinese strings, including the two-character local chunk and four-character global chunk. Male and female human participants were asked to make lexical decisions on these strings in a behavioral experiment, followed by a passive reading task when their electroencephalography (EEG) was recorded. The behavioral results showed that the lexical decision time of lexicalized two-character local chunks was influenced by the lexical status of the four-character global chunk, but not vice versa, which indicated the processing of global chunks possessed priority over the local chunks. The EEG results revealed that familiar lexical chunks were detected simultaneously at both levels and further processed in a different temporal order – the onset of lexical access for the global chunks was earlier than that of local chunks. These consistent results suggest a two-stage operation for chunking in reading–– the simultaneous detection of familiar lexical chunks at multiple levels around 100 ms followed by recognition of chunks with global precedence.

Abstract

In a masked priming word-naming task, a facilitation due to the initial-segmental sound overlap for 2-character kanji prime-target pairs was affected by certain orthographic properties (Yoshihara, Nakayama, Verdonschot, & Hino, 2017). That is, the facilitation that was due to the initial mora overlap occurred only when the mora was the whole pronunciation of their initial kanji characters (i.e., match pairs; e.g., /ka-se.ki/-/ka-rjo.ku/). When the shared initial mora was only a part of the kanji characters' readings, however, there was no facilitation (i.e., mismatch pairs; e.g., /ha.tu-a.N/-/ha.ku-bu.tu/). In the present study, we used a masked priming picture-naming task to investigate whether the previous results were relevant only when the orthography of targets is visually presented. In Experiment 1. the main findings of our word-naming task were fully replicated in a picture-naming task. In Experiments 2 and 3. the absence of facilitation for the mismatch pairs were confirmed with a new set of stimuli. On the other hand, a significant facilitation was observed for the match pairs that shared the 2 initial morae (in Experiment 4), which was again consistent with the results of our word-naming study. These results suggest that the orthographic properties constrain the phonological expression of masked priming for kanji words across 2 tasks that are likely to differ in how phonology is retrieved. Specifically, we propose that orthography of a word is activated online and constrains the phonological encoding processes in these tasks.

Abstract

This article reports on several sub-projects of research and development related to the use of Indian Sign Language in educational settings. In many countries around the world, sign languages are now recognised as the legitimate, full-fledged languages of the deaf communities that use them. In India, the development of sign language resources and their application in educational contexts, is still in its initial stages. The work reported on here, is the first principled and comprehensive effort of establishing educational programmes in Indian Sign Language at a national level. Programmes are of several types: a) Indian Sign Language instruction for hearing people; b) sign language teacher training programmes for deaf people; and c) educational materials for use in schools for the Deaf. The conceptual approach used in the programmes for deaf students is known as bilingual education, which emphasises the acquisition of a first language, Indian Sign Language, alongside the acquisition of spoken languages, primarily in their written form.

Abstract

To acquire the meaning of a verb, language learners not only need to find the correct mapping between a specific verb and an action or event in the world, but also infer the underlying relational meaning that the verb encodes. Most verb naming instances in naturalistic contexts are highly ambiguous as many possible actions can be embedded in the same scenario and many possible verbs can be used to describe those actions. To understand whether learners can find the correct verb meaning from referentially ambiguous learning situations, we conducted three experiments using the Human Simulation Paradigm with adult learners. Our results suggest that although finding the right verb meaning from one learning instance is hard, there is a statistical solution to this problem. When provided with multiple verb learning instances all referring to the same verb, learners are able to aggregate information across situations and gradually converge to the correct semantic space. Even in cases where they may not guess the exact target verb, they can still discover the right meaning by guessing a similar verb that is semantically close to the ground truth.

Abstract

In response to DNA damage or replication stress, the protein kinase ATR is activated and subsequently transduces genotoxic signals to cell cycle control and DNA repair machinery through phosphorylation of a number of downstream substrates. Very little is known about the molecular mechanism by which ATR is activated in response to genotoxic insults. In this report, we demonstrate that protein phosphatase 5 (PP5) is required for the ATR-mediated checkpoint activation. PP5 forms a complex with ATR in a genotoxic stress-inducible manner. Interference with the expression or the activity of PP5 leads to impairment of the ATR-mediated phosphorylation of hRad17 and Chk1 after UV or hydroxyurea treatment. Similar results are obtained in ATM-deficient cells, suggesting that the observed defect in checkpoint signaling is the consequence of impaired functional interaction between ATR and PP5. In cells exposed to UV irradiation, PP5 is required to elicit an appropriate S-phase checkpoint response. In addition, loss of PP5 leads to premature mitosis after hydroxyurea treatment. Interestingly, reduced PP5 activity exerts differential effects on the formation of intranuclear foci by ATR and replication protein A, implicating a functional role for PP5 in a specific stage of the checkpoint signaling pathway. Taken together, our results suggest that PP5 plays a critical role in the ATR-mediated checkpoint activation.

Abstract

Bilinguals usually select the right language to speak for the particular context they are in, but sometimes the nontarget language intrudes. Despite a large body of research into language selection and language control, it remains unclear where intrusion errors originate from. These errors may be due to incorrect selection of the nontarget language at the conceptual level, or be a consequence of erroneous word selection (despite correct language selection) at the lexical level. We examined the former possibility in two language switching experiments using a manipulation that supposedly affects language selection on the conceptual level, namely whether the conversational language context was associated with the target language (congruent) or with the alternative language (incongruent) on a trial. Both experiments showed that language intrusion errors occurred more often in incongruent than in congruent contexts, providing converging evidence that language selection during concept preparation is one driving force behind language intrusion.

Abstract

Bilingual speakers have to control their languages to avoid interference, which may be achieved by enhancing the target language and/or inhibiting the nontarget language. Previous research suggests that bilinguals use inhibition (e.g., Jackson et al., 2001), which should be reflected in the N2 component of the event-related potential (ERP) in the EEG. In the current study, we investigated the dynamics of inhibitory control by measuring the N2 during language switching and repetition in bilingual picture naming. Participants had to name pictures in Dutch or English depending on the cue. A run of same-language trials could be short (two or three trials) or long (five or six trials). We assessed whether RTs and N2 changed over the course of same-language runs, and at a switch between languages. Results showed that speakers named pictures more quickly late as compared to early in a run of same-language trials. Moreover, they made a language switch more quickly after a long run than after a short run. This run-length effect was only present in the first language (L1), not in the second language (L2). In ERPs, we observed a widely distributed switch effect in the N2, which was larger after a short run than after a long run. This effect was only present in the L2, not in the L1, although the difference was not significant between languages. In contrast, the N2 was not modulated during a same-language run. Our results suggest that the nontarget language is inhibited at a switch, but not during the repeated use of the target language.

Abstract

The purpose of this study is to shed light to the linguistic deficit in populations with dementia, and more specifically with Mild Cognitive Impairment and Alzheimer’s Disease; by examining the assignment of thematic roles (θ-roles) in sentences including psychological verbs.
The interest in types of dementia and its precursor is due to the relevance of the disease in present-day world society (Caloi, 2017). 47 millions of people worldwide were reported by the World Alzheimer Report in 2016 (Prince et al. 2016) as people with a type of dementia. This number surpasses the number of inhabitants in Spain, a whole country, and it is expected, according to the report, to triplicate until 2050 reaching the number of 131 million. The impact of this disease is observed not only at the social level but also in the economic one, because of their need for assistance in their everyday life. What is worrying, is the lack of total treatment once the disease has started. Despite the efforts of medicine, dementia is problematic in terms of its diagnosis, because a variety of cognitive abilities is assessed in combination with medical workup. Language is a crucial component in the procedure of diagnosis as linguistic deficits are among the first symptoms that accompany the onset of the disease. Therefore, further investigation of linguistic impairment is a necessity in order to enhance the diagnostic techniques used nowadays. Furthermore, the lack of efficient drugs for the treatment of the disease has necessitated the development of training programs for maintenance and increase of the cognitive abilities in people with either Mild Cognitive Impairment or a type of dementia …

Abstract

In informal interaction, speakers rarely thank a person who has complied with a request. Examining data from British English, German, Italian, Polish, and Telugu, we ask when speakers do thank after compliance. The results show that thanking treats the other’s assistance as going beyond what could be taken for granted in the circumstances. Coupled with the rareness of thanking after requests, this suggests that cooperation is to a great extent governed by expectations of helpfulness, which can be long-standing, or built over the course of a particular interaction. The higher frequency of thanking in some languages (such as English or Italian) suggests that cultures differ in the importance they place on recognizing the other’s agency in doing as requested.

Abstract

Change in linguistic prosody generates a mismatch negativity response (MMN), indicating neural representation of linguistic prosody, while change in affective prosody generates a positive response (P3a), reflecting its motivational salience. However, the neural response to concurrent affective and linguistic prosody is unknown. The present paper investigates the integration of these two prosodic features in the brain by examining the neural response to separate and concurrent processing by electroencephalography (EEG). A spoken pair of Swedish words—[ˈfɑ́ːsɛn] phase and [ˈfɑ̀ːsɛn] damn—that differed in emotional semantics due to linguistic prosody was presented to 16 subjects in an angry and neutral affective prosody using a passive auditory oddball paradigm. Acoustically matched pseudowords—[ˈvɑ́ːsɛm] and [ˈvɑ̀ːsɛm]—were used as controls. Following the constructionist concept of emotions, accentuating the conceptualization of emotions based on language, it was hypothesized that concurrent affective and linguistic prosody with the same valence—angry [ˈfɑ̀ːsɛn] damn—would elicit a unique late EEG signature, reflecting the temporal integration of affective voice with emotional semantics of prosodic origin. In accordance, linguistic prosody elicited an MMN at 300–350 ms, and affective prosody evoked a P3a at 350–400 ms, irrespective of semantics. Beyond these responses, concurrent affective and linguistic prosody evoked a late positive component (LPC) at 820–870 ms in frontal areas, indicating the conceptualization of affective prosody based on linguistic prosody. This study provides evidence that the brain does not only distinguish between these two functions of prosody but also integrates them based on language and experience.

Abstract

There is a rich tradition of building computational models in cognitive science, but modeling, theoretical, and experimental research are not as tightly integrated as they could be. In this paper, we show that computational techniques—even simple ones that are straightforward to use—can greatly facilitate designing, implementing, and analyzing experiments, and generally help lift research to a new level. We focus on the domain of artificial grammar learning, and we give five concrete examples in this domain for (a) formalizing and clarifying theories, (b) generating stimuli, (c) visualization, (d) model selection, and (e) exploring the hypothesis space.