Displaying 801 - 806 of 806
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Zhang, J., Bao, S., Furumai, R., Kucera, K. S., Ali, A., Dean, N. M., & Wang, X.-F. (2005). Protein phosphatase 5 is required for ATR-mediated checkpoint activation. Molecular and Cellular Biology, 25, 9910-9919. doi:10.1128/MCB.25.22.9910-9919.2005.
Abstract
In response to DNA damage or replication stress, the protein kinase ATR is activated and subsequently transduces genotoxic signals to cell cycle control and DNA repair machinery through phosphorylation of a number of downstream substrates. Very little is known about the molecular mechanism by which ATR is activated in response to genotoxic insults. In this report, we demonstrate that protein phosphatase 5 (PP5) is required for the ATR-mediated checkpoint activation. PP5 forms a complex with ATR in a genotoxic stress-inducible manner. Interference with the expression or the activity of PP5 leads to impairment of the ATR-mediated phosphorylation of hRad17 and Chk1 after UV or hydroxyurea treatment. Similar results are obtained in ATM-deficient cells, suggesting that the observed defect in checkpoint signaling is the consequence of impaired functional interaction between ATR and PP5. In cells exposed to UV irradiation, PP5 is required to elicit an appropriate S-phase checkpoint response. In addition, loss of PP5 leads to premature mitosis after hydroxyurea treatment. Interestingly, reduced PP5 activity exerts differential effects on the formation of intranuclear foci by ATR and replication protein A, implicating a functional role for PP5 in a specific stage of the checkpoint signaling pathway. Taken together, our results suggest that PP5 plays a critical role in the ATR-mediated checkpoint activation. -
Zwitserlood, I. (2011). Gebruiksgemak van het eerste Nederlandse Gebarentaal woordenboek kan beter [Book review]. Levende Talen Magazine, 4, 46-47.
Abstract
Review: User friendliness of the first dictionary of Sign Language of the Netherlands can be improved -
Zwitserlood, I. (2011). Gevraagd: medewerkers verzorgingshuis met een goede oog-handcoördinatie. Het meten van NGT-vaardigheid. Levende Talen Magazine, 1, 44-46.
Abstract
(Needed: staff for residential care home with good eye-hand coordination. Measuring NGT-skills.) -
Zwitserlood, I. (2002). Klassifikatoren in der Niederländischen Gebärdensprache (NGT). In H. Leuniger, & K. Wempe (
Eds. ), Gebärdensprachlinguistik 2000. Theorie und Anwendung. Vorträge vom Symposium "Gebärdensprachforschung im deutschsprachigem Raum", Frankfurt a.M., 11.-13. Juni 1999 (pp. 113-126). Hamburg: Signum Verlag. -
Zwitserlood, I. (2011). Het Corpus NGT en de dagelijkse lespraktijk. Levende Talen Magazine, 6, 46.
Abstract
(The Corpus NGT and the daily practice of language teaching) -
Zwitserlood, I. (2011). Het Corpus NGT en de opleiding leraar/tolk NGT. Levende Talen Magazine, 1, 40-41.
Abstract
(The Corpus NGT and teacher NGT/interpreter NGT training)
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