Publications

Abstract

The KE family is a large three-generation pedigree in which half the members are affected with a severe speech and language disorder that is transmitted as an autosomal dominant monogenic trait. In previously published work, we localized the gene responsible (SPCH1) to a 5.6-cM region of 7q31 between D7S2459 and D7S643. In the present study, we have employed bioinformatic analyses to assemble a detailed BAC-/PAC-based sequence map of this interval, containing 152 sequence tagged sites (STSs), 20 known genes, and >7.75 Mb of completed genomic sequence. We screened the affected chromosome 7 from the KE family with 120 of these STSs (average spacing <100 kb), but we did not detect any evidence of a microdeletion. Novel polymorphic markers were generated from the sequence and were used to further localize critical recombination breakpoints in the KE family. This allowed refinement of the SPCH1 interval to a region between new markers 013A and 330B, containing ∼6.1 Mb of completed sequence. In addition, we have studied two unrelated patients with a similar speech and language disorder, who have de novo translocations involving 7q31. Fluorescence in situ hybridization analyses with BACs/PACs from the sequence map localized the t(5;7)(q22;q31.2) breakpoint in the first patient (CS) to a single clone within the newly refined SPCH1 interval. This clone contains the CAGH44 gene, which encodes a brain-expressed protein containing a large polyglutamine stretch. However, we found that the t(2;7)(p23;q31.3) breakpoint in the second patient (BRD) resides within a BAC clone mapping >3.7 Mb distal to this, outside the current SPCH1 critical interval. Finally, we investigated the CAGH44 gene in affected individuals of the KE family, but we found no mutations in the currently known coding sequence. These studies represent further steps toward the isolation of the first gene to be implicated in the development of speech and language.

Abstract

The order of acquisition of Dutch syllable types by first language learners is analyzed as following from an initial ranking and subsequent rerankings of constraints in an optimality theoretic grammar. Initially, structural constraints are all ranked above faithfulness constraints, leading to core syllable (CV) productions only. Subsequently, faithfulness gradually rises to the highest position in the ranking, allowing more and more marked syllable types to appear in production. Local conjunctions of Structural constraints allow for a more detailed analysis.

Abstract

Preparing words in speech production is normally a fast and accurate process. We generate them two or three per second in fluent conversation; and overtly naming a clear picture of an object can easily be initiated within 600 msec after picture onset. The underlying process, however, is exceedingly complex. The theory reviewed in this target article analyzes this process as staged and feedforward. After a first stage of conceptual preparation, word generation proceeds through lexical selection, morphological and phonological encoding, phonetic encoding, and articulation itself. In addition, the speaker exerts some degree of output control, by monitoring of self-produced internal and overt speech. The core of the theory, ranging from lexical selection to the initiation of phonetic encoding, is captured in a computational model, called WEAVER + +. Both the theory and the computational model have been developed in interaction with reaction time experiments, particularly in picture naming or related word production paradigms, with the aim of accounting. for the real-time processing in normal word production. A comprehensive review of theory, model, and experiments is presented. The model can handle some of the main observations in the domain of speech errors (the major empirical domain for most other theories of lexical access), and the theory opens new ways of approaching the cerebral organization of speech production by way of high-temporal-resolution imaging.

Abstract

Research on spoken word production has been approached from two angles. In one research tradition, the analysis of spontaneous or induced speech errors led to models that can account for speech error distributions. In another tradition, the measurement of picture naming latencies led to chronometric models accounting for distributions of reaction times in word production. Both kinds of models are, however, dealing with the same underlying processes: (1) the speaker’s selection of a word that is semantically and syntactically appropriate; (2) the retrieval of the word’s phonological properties; (3) the rapid syllabification of the word in context; and (4) the preparation of the corresponding articulatory gestures. Models of both traditions explain these processes in terms of activation spreading through a localist, symbolic network. By and large, they share the main levels of representation: conceptual/semantic, syntactic, phonological and phonetic. They differ in various details, such as the amount of cascading and feedback in the network. These research traditions have begun to merge in recent years, leading to highly constructive experimentation. Currently, they are like two similar knives honing each other. A single pair of scissors is in the making.

Abstract

In recent decades, psychologists have become increasingly interested in our ability to speak. This paper sketches the present theoretical perspective on this most complex skill of homo sapiens. The generation of fluent speech is based on the interaction of various processing components. These mechanisms are highly specialized, dedicated to performing specific subroutines, such as retrieving appropriate words, generating morpho-syntactic structure, computing the phonological target shape of syllables, words, phrases and whole utterances, and creating and executing articulatory programmes. As in any complex skill, there is a self-monitoring mechanism that checks the output. These component processes are targets of increasingly sophisticated experimental research, of which this paper presents a few salient examples.

Abstract

In this article, we present an account of developmental data regarding the acquisition of syllable types. The data come from a longitudinal corpus of phonetically transcribed speech of 12 children acquiring Dutch as their first language. A developmental order of acquisition of syllable types was deduced by aligning the syllabified data on a Guttman scale. This order could be analyzed as following from an initial ranking and subsequent rerankings in the grammar of the structural constraints ONSET, NO-CODA, *COMPLEX-O, and *COMPLEX-C; some local conjunctions of these constraints; and a faithfulness constraint FAITH. The syllable type frequencies in the speech surrounding the language learner are also considered. An interesting correlation is found between the frequencies and the order of development of the different syllable types.

Abstract

Recent work on sentence recognition suggests that listeners use their knowledge of the language to directly infer deep structure syntactic relations from surface structure markers. Suffixes may be such clues, especially in agglutinative languages. A cross-language (Dutch-Finnish) experiment is reported, designed to investigate whether the suffix structure of Finnish words (as opposed to suffixless Dutch words) can facilitate prompted recall of sentences in case these suffixes differentiate between possible deep structures. The experiment, in which 80 subjects recall sentences at the occasion of prompt words, gives only slight confirmatory evidence. Meanwhile, another prompted recall effect (Blumenthal's) could not be replicated.

Abstract

Speakers tend to repeat materials from previous talk. This tendency is experimentally established and manipulated in various question-answering situations. It is shown that a question's surface form can affect the format of the answer given, even if this form has little semantic or conversational consequence, as in the pair Q: (At) what time do you close. A: “(At)five o'clock.” Answerers tend to match the utterance to the prepositional (nonprepositional) form of the question. This “correspondence effect” may diminish or disappear when, following the question, additional verbal material is presented to the answerer. The experiments show that neither the articulatory buffer nor long-term memory is normally involved in this retention of recent speech. Retaining recent speech in working memory may fulfill a variety of functions for speaker and listener, among them the correct production and interpretation of surface anaphora. Reusing recent materials may, moreover, be more economical than regenerating speech anew from a semantic base, and thus contribute to fluency. But the realization of this strategy requires a production system in which linguistic formulation can take place relatively independent of, and parallel to, conceptual planning.

Abstract

It is quite normal for us to produce one or two million word tokens every year. Speaking is a dear occupation and producing words is at the core of it. Still, producing even a single word is a highly complex affair. Recently, Levelt, Roelofs, and Meyer (1999) reviewed their theory of lexical access in speech production, which dissects the word-producing mechanism as a staged application of various dedicated operations. The present paper begins by presenting a bird eye's view of this mechanism. We then square the complexity by asking how speakers control multiple access in generating simple utterances such as a table and a chair. In particular, we address two issues. The first one concerns dependency: Do temporally contiguous access procedures interact in any way, or do they run in modular fashion? The second issue concerns temporal alignment: How much temporal overlap of processing does the system tolerate in accessing multiple content words, such as table and chair? Results from picture-word interference and eye tracking experiments provide evidence for restricted cases of dependency as well as for constraints on the temporal alignment of access procedures.

Abstract

The theory of basic color terms was a crucial factor in the demise of linguistic relativity. The theory is now once again under scrutiny and fundamental revision. This article details a case study that undermines one of the central claims of the classical theory, namely that languages universally treat color as a unitary domain, to be exhaustively named. Taken together with other cases, the study suggests that a number of languages have only an incipient color terminology, raising doubts about the linguistic universality of such terminology.

Abstract

Several models of spoken word recognition postulate that recognition is achieved via a process of competition between lexical hypotheses. Competition not only provides a mechanism for isolated word recognition, it also assists in continuous speech recognition, since it offers a means of segmenting continuous input into individual words. We present statistics on the pattern of occurrence of words embedded in the polysyllabic words of the English vocabulary, showing that an overwhelming majority (84%) of polysyllables have shorter words embedded within them. Positional analyses show that these embeddings are most common at the onsets of the longer word. Although both phonological and syntactic constraints could rule out some embedded words, they do not remove the problem. Lexical competition provides a means of dealing with lexical embedding. It is also supported by a growing body of experimental evidence. We present results which indicate that competition operates both between word candidates that begin at the same point in the input and candidates that begin at different points (McQueen, Norris, & Cutler, 1994, Noms, McQueen, & Cutler, in press). We conclude that lexical competition is an essential component in models of continuous speech recognition.

Abstract

In 5 experiments, listeners heard words and nonwords, some cross-spliced so that they contained acoustic-phonetic mismatches. Performance was worse on mismatching than on matching items. Words cross-spliced with words and words cross-spliced with nonwords produced parallel results. However, in lexical decision and 1 of 3 phonetic decision experiments, performance on nonwords cross-spliced with words was poorer than on nonwords cross-spliced with nonwords. A gating study confirmed that there were misleading coarticulatory cues in the cross-spliced items; a sixth experiment showed that the earlier results were not due to interitem differences in the strength of these cues. Three models of phonetic decision making (the Race model, the TRACE model, and a postlexical model) did not explain the data. A new bottom-up model is outlined that accounts for the findings in terms of lexical involvement at a dedicated decision-making stage.

Abstract

A comparison of Merge, a model of comprehension, and WEAVER, a model of production, raises five issues: (1) merging models of comprehension and production necessarily creates feedback; (2) neither model is a comprehensive account of word processing; (3) the models are incomplete in different ways; (4) the models differ in their handling of competition; (5) as opposed to WEAVER, Merge is a model of metalinguistic behavior.

Abstract

The production and interpretation of pronouns involves the identification of a mental referent and, in connected speech or text, a discourse antecedent. One of the few overt signals of the relationship between a pronoun and its antecedent is agreement in features such as number and grammatical gender. To examine how speakers create these signals, two experiments tested conceptual, lexical. and morphophonological accounts of pronoun production in Dutch. The experiments employed sentence completion and continuation tasks with materials containing noun phrases that conflicted or agreed in grammatical gender. The noun phrases served as the antecedents for demonstrative pronouns tin Experiment 1) and relative pronouns tin Experiment 2) that required gender marking. Gender errors were used to assess the nature of the processes that established the link between pronouns and antecedents. There were more gender errors when candidate antecedents conflicted in grammatical gender, counter to the predictions of a pure conceptual hypothesis. Gender marking on candidate antecedents did not change the magnitude of this interference effect, counter to the predictions of an overt-morphology hypothesis. Mirroring previous findings about pronoun comprehension, the results suggest that speakers of gender-marking languages call on specific linguistic information about antecedents in order to select pronouns and that the information consists of specifications of grammatical gender associated with the lemmas of words.

Abstract

Spoken utterances contain few reliable cues to word boundaries, but listeners nonetheless experience little difficulty identifying words in continuous speech. The authors present data and simulations that suggest that this ability is best accounted for by a model of spoken-word recognition combining competition between alternative lexical candidates and sensitivity to prosodic structure. In a word-spotting experiment, stress pattern effects emerged most clearly when there were many competing lexical candidates for part of the input. Thus, competition between simultaneously active word candidates can modulate the size of prosodic effects, which suggests that spoken-word recognition must be sensitive both to prosodic structure and to the effects of competition. A version of the Shortlist model ( D. G. Norris, 1994b) incorporating the Metrical Segmentation Strategy ( A. Cutler & D. Norris, 1988) accurately simulates the results using a lexicon of more than 25,000 words.

Abstract

The central thesis of the target article was that feedback is never necessary in spoken word recognition. The commentaries present no new data and no new theoretical arguments which lead us to revise this position. In this response we begin by clarifying some terminological issues which have lead to a number of significant misunderstandings. We provide some new arguments to support our case that the feedforward model Merge is indeed more parsimonious than the interactive alternatives, and that it provides a more convincing account of the data than alternative models. Finally, we extend the arguments to deal with new issues raised by the commentators such as infant speech perception and neural architecture.

Abstract

Top-down feedback does not benefit speech recognition; on the contrary, it can hinder it. No experimental data imply that feedback loops are required for speech recognition. Feedback is accordingly unnecessary and spoken word recognition is modular. To defend this thesis, we analyse lexical involvement in phonemic decision making. TRACE (McClelland & Elman 1986), a model with feedback from the lexicon to prelexical processes, is unable to account for all the available data on phonemic decision making. The modular Race model (Cutler & Norris 1979) is likewise challenged by some recent results, however. We therefore present a new modular model of phonemic decision making, the Merge model. In Merge, information flows from prelexical processes to the lexicon without feedback. Because phonemic decisions are based on the merging of prelexical and lexical information, Merge correctly predicts lexical involvement in phonemic decisions in both words and nonwords. Computer simulations show how Merge is able to account for the data through a process of competition between lexical hypotheses. We discuss the issue of feedback in other areas of language processing and conclude that modular models are particularly well suited to the problems and constraints of speech recognition.

Abstract

Two recent studies (Coulson et al., 1998;Osterhout et al., 1996)examined the
relationship between the event-related brain potential (ERP) responses to linguistic syntactic anomalies (P600/SPS) and domain-general unexpected events (P300). Coulson et al. concluded that these responses are highly similar, whereas Osterhout et al. concluded that they are distinct. In this comment, we evaluate the relativemerits of these claims. We conclude that the available evidence indicates that the ERP response to syntactic anomalies is at least partially distinct from the ERP response to unexpected anomalies that do not involve a grammatical violation

Abstract

Two experiments examined the processing of Tokyo Japanese pitchaccent distinctions by native speakers of Japanese from two accentlessvariety areas. In both experiments, listeners were presented with Tokyo Japanese speech materials used in an earlier study with Tokyo Japanese listeners, who clearly exploited the pitch-accent information in spokenword recognition. In the "rst experiment, listeners judged from which of two words, di!ering in accentual structure, isolated syllables had been extracted. Both new groups were, overall, as successful at this task as Tokyo Japanese speakers had been, but their response patterns differed from those of the Tokyo Japanese, for instance in that a bias towards H judgments in the Tokyo Japanese responses was weakened in the present groups' responses. In a second experiment, listeners heard word fragments and guessed what the words were; in this task, the speakers from accentless areas again performed significantly above chance, but their responses showed less sensitivity to the information in the input, and greater bias towards vocabulary distribution frequencies, than had been observed with the Tokyo Japanese listeners. The results suggest that experience with a local accentless dialect affects the processing of accent for word recognition in Tokyo Japanese, even for listeners with extensive exposure to Tokyo Japanese.

Abstract

In the present PET study we explore some functional aspects of the interaction between attentional/control processes and learning/memory processes. The network of brain regions supporting recall of abstract designs were studied in a less practiced and in a well practiced state. The results indicate that automaticity, i.e., a decreased dependence on attentional and working memory resources, develops as a consequence of practice. This corresponds to the practice related decreases of activity in the prefrontal, anterior cingulate, and posterior parietal regions. In addition, the activity of the medial temporal regions decreased as a function of practice. This indicates an inverse relation between the strength of encoding and the activation of the MTL during retrieval. Furthermore, the pattern of practice related increases in the auditory, posterior insular-opercular extending into perisylvian supra marginal region, and the right mid occipito-temporal region, may reflect a lower degree of inhibitory attentional modulation of task irrelevant processing and more fully developed representations of the abstract designs, respectively. We also suggest that free recall is dependent on bilateral prefrontal processing, in particular non-automatic free recall. The present results cofirm previous functional neuroimaging studies of memory retrieval indicating that recall is subserved by a network of interacting brain regions. Furthermore, the results indicate that some components of the neural network subserving free recall may have a dynamic role and that there is a functional restructuring of the information processing networks during the learning process.

Abstract

Recent event-related FMRI studies indicate that the prefrontal (PFC) and the medial temporal lobe (MTL) regions are more active during effective encoding than during ineffective encoding. The within-subject design and the use of well-educated young college students in these studies makes it important to replicate these results in other study populations. In this PET study, we used an auditory word-pair association cued-recall paradigm and investigated a group of healthy upper middle-aged/older illiterate women. We observed a positive correlation between cued-recall success and the regional cerebral blood flow of the left inferior PFC (BA 47) and the MTLs. Specifically, we used the cuedrecall success as a covariate in a general linear model and the results confirmed that the left inferior PFC and the MTLare more active during effective encoding than during ineffective encoding. These effects were observed during encoding of both semantically and phonologically related word pairs, indicating that these effects are robust in the studied population, that is, reproducible within group. These results generalize the results of Brewer et al. (1998, Science 281, 1185– 1187) and Wagner et al. (1998, Science 281, 1188–1191) to an upper middle aged/older illiterate population. In addition, the present study indicates that effective relational encoding correlates positively with the activity of the anterior medial temporal lobe regions.

Abstract

A fundamental problem in the study of learning is that learning-related changes may be confounded by nonspecific time effects. There are several strategies for handling this problem. This problem may be of greater significance in functional magnetic resonance imaging (fMRI) compared to positron emission tomography (PET). Using the general linear model, we describe, compare, and discuss two approaches for separating learning-related from nonspecific time effects. The first approach makes assumptions on the general behavior of nonspecific effects and explicitly models these effects, i.e., nonspecific time effects are incorporated as a linear or nonlinear confounding covariate in the statistical model. The second strategy makes no a priori assumption concerning the form of nonspecific time effects, but implicitly controls for nonspecific effects using an interaction approach, i.e., learning effects are assessed with an interaction contrast. The two approaches depend on specific assumptions and have specific limitations. With certain experimental designs, both approaches may be used and the results compared, lending particular support to effects that are independent of the method used. A third and perhaps better approach that sometimes may be practically unfeasible is to use a completely temporally balanced experimental design. The choice of approach may be of particular importance when learning related effects are studied with fMRI.

Abstract

The objective of this study was to investigate the central processing of dynamic mechanical allodynia in patients with mononeuropathy. Regional cerebral bloodflow, as an indicator of neuronal activity, was measured with positron emission tomography. Paired comparisons were made between three different states; rest, allodynia during brushing the painful skin area, and brushing of the homologous contralateral area. Bilateral activations were observed in the primary somatosensory cortex (S1) and the secondary somatosensory cortex (S2) during allodynia compared to rest. The S1 activation contralateral to the site of the stimulus was more expressed during allodynia than during innocuous touch. Significant activations of the contralateral posterior parietal cortex, the periaqueductal gray (PAG), the thalamus bilaterally and motor areas were also observed in the allodynic state compared to both non-allodynic states. In the anterior cingulate cortex (ACC) there was only a suggested activation when the allodynic state was compared with the non-allodynic states. In order to account for the individual variability in the intensity of allodynia and ongoing spontaneous pain, rCBF was regressed on the individually reported pain intensity, and significant covariations were observed in the ACC and the right anterior insula. Significantly decreased regional blood flow was observed bilaterally in the medial and lateral temporal lobe as well as in the occipital and posterior cingulate cortices when the allodynic state was compared to the non-painful conditions. This finding is consistent with previous studies suggesting attentional modulation and a central coping strategy for known and expected painful stimuli. Involvement of the medial pain system has previously been reported in patients with mononeuropathy during ongoing spontaneous pain. This study reveals a bilateral activation of the lateral pain system as well as involvement of the medial pain system during dynamic mechanical allodynia in patients with mononeuropathy.

Abstract

It has previously been suggested that the activity in sensory regions of the brain can be modulated by attentional mechanisms during parallel cognitive processing. To investigate whether such attention-related modulations are present in the processing of pain, the regional cerebral blood ¯ow was measured using [15O]butanol and positron emission tomography in conditions involving both pain and parallel cognitive demands. The painful stimulus consisted of the standard cold pressor test and the cognitive task was a computerised perceptual maze test. The activations during the maze test reproduced findings in previous studies of the same cognitive task. The cold pressor test evoked signi®cant activity in the contralateral S1, and bilaterally in the somatosensory association areas (including S2), the ACC and the mid-insula. The activity in the somatosensory association areas and periaqueductal gray/midbrain were significantly modified, i.e. relatively decreased, when the subjects also were performing the maze task. The altered activity was accompanied with significantly lower ratings of pain during the cognitive task. In contrast, lateral orbitofrontal regions showed a relative increase of activity during pain combined with the maze task as compared to only pain, which suggests the possibility of the involvement of frontal cortex in modulation of regions processing pain

Abstract

In this paper hypothesis‐testing behaviour is compared to risk‐taking behaviour. It is proposed that choosing a suitable test for a given hypothesis requires making a preposterior analysis of two aspects of such a test: the probability of obtaining supporting evidence and the evidential value of this evidence. This consideration resembles the one a gambler makes when choosing among bets, each having a probability of winning and an amount to be won. A confirmatory testing strategy can be defined within this framework as a strategy directed at maximizing either the probability or the value of a confirming outcome. Previous theories on testing behaviour have focused on the human tendency to maximize the probability of a confirming outcome. In this paper, two experiments are presented in which participants tend to maximize the confirming value of the test outcome. Motivational factors enhance this tendency dependent on the context of the testing situation. Both this result and the framework are discussed in relation to other studies in the field of testing behaviour.

Abstract

This study investigated characteristics of motor cortex activation and response generation in Parkinson's disease with measures of electrocortical activity (lateralized readiness potential [LRP]), electromyographic activity (EMG), and isometric force in a noise-compatibility task. When presented with stimuli consisting of incompatible target and distracter elements asking for responses of opposite hands, patients were less able than control subjects to suppress activation of the motor cortex controlling the wrong response hand. This was manifested in the pattern of reaction times and in an incorrect lateralization of the LRP. Onset latency and rise time of the LRP did not differ between patients and control subjects, but EMG and response force developed more slowly in patients. Moreover, in patients but not in control subjects, the rate of development of EMG and response force decreased as reaction time increased. We hypothesize that this dissociation between electrocortical activity and peripheral measures in Parkinson's disease is the result of changes in motor cortex function that alter the relation between signal-related and movement-related neural activity in the motor cortex. In the LRP, this altered balance may obscure an abnormal development of movement-related neural activity.

Abstract

The present paper reports an analysis of correct wh-question production and subject–auxiliary inversion errors in one child's early wh-question data (age 2; 3.4 to 4; 10.23). It is argued that two current movement rule accounts (DeVilliers, 1991; Valian, Lasser & Mandelbaum, 1992) cannot explain the patterning of early wh-questions. However, the data can be explained in terms of the child's knowledge of particular lexically-specific wh-word+auxiliary combinations, and the pattern of inversion and uninversion predicted from the relative frequencies of these combinations in the mother's speech. The results support the claim that correctly inverted wh-questions can be produced without access to a subject–auxiliary inversion rule and are consistent with the constructivist claim that a distributional learning mechanism that learns and reproduces lexically-specific formulae heard in the input can explain much of the early multi-word speech data. The implications of these results for movement rule-based and constructivist theories of grammatical development are discussed.

Abstract

Capacity limited memory systems need to gradually forget old information in order to avoid catastrophic forgetting where all stored information is lost. This can be achieved by allowing new information to overwrite old, as in the so-called palimpsest memory. This paper describes a new such learning rule employed in an attractor neural network. The network does not exhibit catastrophic forgetting, has a capacity dependent on the learning time constant and exhibits recency e!ects in retrieval

Abstract

Speakers can use pronouns when their conceptual referents are accessible from the preceding discourse, as in 'The flower is red. It turns blue'. Theories of language production agree that in order to produce a noun semantic, syntactic, and phonological information must be accessed. However, little is known about lexical access to pronouns. In this paper, we propose a model of pronoun access in German. Since the forms of German pronouns depend on the grammatical gender of the nouns they replace, the model claims that speakers must access the syntactic representation of the replaced noun (its lemma) to select a pronoun. In two experiments using the lexical decision during naming paradigm [Levelt, W.J.M., Schriefers, H., Vorberg, D., Meyer, A.S., Pechmann, T., Havinga, J., 1991a. The time course of lexical access in speech production: a study of picture naming. Psychological Review 98, 122-142], we investigated whether lemma access automatically entails the activation of the corresponding word form or whether a word form is only activated when the noun itself is produced, but not when it is replaced by a pronoun. Experiment 1 showed that during pronoun production the phonological form of the replaced noun is activated. Experiment 2 demonstrated that this phonological activation was not a residual of the use of the noun in the preceding sentence. Thus, when a pronoun is produced, the lemma and the phonological form of the replaced noun become reactivated.

Abstract

Recent research in speech production has shown that syntactic structure is reflected in segmental phonology--the application of certain phonological rules of English (e.g., palatalization and alveolar flapping) is inhibited across phrase boundaries. We examined whether such segmental effects can be used in speech perception as cues to syntactic structure, and the relation between the use of these segmental features as syntactic markers in production and perception. Speakers of American English (a dialect in which the above segmental effects occur) could indeed use the segmental cues in syntax perception; speakers of British English (in which the effects do not occur) were unable to make use of them, while speakers of British English who were long-term residents of the United States showed intermediate performance.

Abstract

Visiting the Trobriand Islands is advertised as being the highlight of a trip for tourists to Papua New Guinea who want, and can afford, to experience this 'ultimate adventure' with 'expeditionary cruises aboard the luxurious Melanesian Discoverer. The advertisements also promise that the tourists can 'meet the friendly people' and 'observe their unique culture, dances, and art'. During my research in Kaibola and Nuwebila, two neighbouring villages on the northern tip of Kiriwina Island, I studied and analysed the encounters of tourists with Trobriand Islanders, who sing and dance for the Europeans. The analyses of the islanders' tourist performances are based on Erving Goffman's now classic study The Presentation of Self in Everyday Life, which was first published in 1959. In this study Goffmann analyses the structures of social encounters from the perspective of the dramatic performance. The situational context within which the encounter between tourists and Trobriand Islanders takes place frames the tourists as the audience and the Trobriand Islanders as a team of performers. The inherent structure of the parts of the overall performance presented in the two villages can be summarized - within the framework of Goffman's approach - in analogy with the structure of drama. We find parts that constitute the 'exposition', the 'complication', and the 'resolution' of a drama; we even observe an equivalent to the importance of the 'Second Act Curtain' in modern drama theory. Deeper analyses of this encounter show that the motives of the performers and their 'art of impression management' are to control the impression their audience receives in this encounter situation. This analysis reveals that the Trobriand Islanders sell their customers the expected images of what Malinowski (1929) once termed the '...Life of Savages in North-Western Melanesia' in a staged 'illusion'. With the conscious realization of the part they as performers play in this encounter, the Trobriand Islanders are in a position that is superior to that of their audience. Their merchandise or commodity is 'not real', as it is sold 'out of its true cultural context'. It is staged - and thus cannot be taken by any customer whatsoever because it (re)presents just an 'illusion'. The Trobriand Islanders know that neither they nor the core aspects of their culture will suffer any damage within a tourist encounter that is defined by the structure and the kind of their performance. Their pride and self-confidence enable them to bring their superior position into play in their dealings with tourists. With their indigenous humour, they even use this encounter for ridiculing their visitors. It turns out that the encounter is another manifestation of the Trobriand Islanders' self-consciousness, self-confidence, and pride with which they manage to protect core aspects of their cultural identity, while at the same time using and 'selling' parts of their culture as a kind of commodity to tourists.

Abstract

A t(X;1)(p11.2;q21.2) has been reported in cases of papillary renal cell tumors arising in males. In this study two cell lines derived from this tumor type have been used to indicate the breakpoint region on the X chromosome. Both cell lines have the translocation in addition to other rearrangements and one is derived from the first female case to be reported with the t(X;1)(p11.2;q21.2). Fluorescence in situ hybridization (FISH) has been used to position YACs belonging to contigs in the Xp11.2 region relative to the breakpoint. When considered together with detailed mapping information from the Xp11.2 region the position of the breakpoint in both cell lines was suggested as follows: Xpter-->Xp11.23-OATL1-GATA1-WAS-TFE3-SY P-t(X;1)-DXS255-CLCN5-DXS146-OATL2- Xp11.22-->Xcen. The breakpoint was determined to lie in an uncloned region between SYP and a YAC called FTDM/1 which extends 1 Mb distal to DXS255. These results are contrary to the conclusion from previous FISH studies that the breakpoint was near the OATL2 locus, but are consistent with, and considerably refine, the position that had been established by molecular analysis.

Abstract

The temporal distribution of perceptually relevant information for consonant recognition in British English VCVs is investigated. The information distribution in the vicinity of consonantal closure and release was measured by presenting initial and final portions, respectively, of naturally produced VCV utterances to listeners for categorization. A multidimensional scaling analysis of the results provided highly interpretable, four-dimensional geometrical representations of the confusion patterns in the categorization data. In addition, transmitted information as a function of truncation point was calculated for the features manner place and voicing. The effects of speaker, vowel context, stress, and distinctive feature on the resulting information distributions were tested statistically. It was found that, although all factors are significant, the location and spread of the distributions depends principally on the distinctive feature, i.e., the temporal distribution of perceptually relevant information is very different for the features manner, place, and voicing.

Abstract

We present results from cross-modal priming experiments on German participles and noun plurals. The experiments produced parallel results for both inflectional systems. Regular inflection exhibits full priming whereas irregularly inflected word forms show only partial priming: after hearing regularly inflected words (-t participles and -s plurals), lexical decision times on morphologically related word forms (presented visually) were similar to reaction times for a base-line condition in which prime and target were identical, but significantly shorter than in a control condition where prime and target were unrelated. In contrast, prior presentation of irregular words (-n participles and -er plurals) led to significantly longer response times on morphologically related word forms than the prior presentation of the target itself. Hence, there are clear priming differences between regularly and irregularly inflected German words. We compare the findings on German with experimental results on regular and irregular inflection in English and Italian, and discuss theoretical implications for single versus dual-mechanism models of inflection.

Abstract

Although children's knowledge of the sound patterns of words has been a focus of debate for many years, little is known about the lexical representations very young children use in word recognition. In particular, researchers have questioned the degree of specificity encoded in early lexical representations. The current study addressed this issue by presenting 18–23-month-olds with object labels that were either correctly pronounced, or mispronounced. Mispronunciations involved replacement of one segment with a similar segment, as in ‘baby–vaby’. Children heard sentences containing these words while viewing two pictures, one of which was the referent of the sentence. Analyses of children's eye movements showed that children recognized the spoken words in both conditions, but that recognition was significantly poorer when words were mispronounced. The effects of mispronunciation on recognition were unrelated to age or to spoken vocabulary size. The results suggest that children's representations of familiar words are phonetically well-specified, and that this specification may not be a consequence of the need to differentiate similar words in production.

Abstract

The murine homologue of the human chloride channel gene, CLCN5, defects in which are responsible for Dent disease, has been cloned and characterized. We isolated the entire coding region of mouse Clcn5 cDNA and approximately 45 kb of genomic sequence embracing the gene. To study its transcriptional control, the 5' upstream sequences of the mouse Clcn5 gene were cloned into a luciferase reporter vector. Deletion analysis of 1.5 kb of the 5' flanking sequence defined an active promoter region within 128 bp of the putative transcription start site, which is associated with a TATA motif but lacks a CAAT consensus. Within this sequence, there is a motif with homology to a purine-rich sequence responsible for the kidney-specific promoter activity of the rat CLC-K1 gene, another member of the chloride-channel gene family expressed in kidney. An enhancer element that confers a 10- to 20-fold increase in the promoter activity of the mouse Clcn5 gene was found within the first intron. The organization of the human CLCN5 and mouse Clcn5 gene structures is highly conserved, and the sequence of the murine protein is 98% similar to that of human, with its highest expression seen in the kidney. This study thus provides the first identification of the transcriptional control region of, and the basis for an understanding of the regulatory mechanism that controls, this kidney-specific, chloride-channel gene.

Abstract

A growing number of researchers in the sentence processing community are using eye movements to address issues in spoken language comprehension. Experiments using this paradigm have shown that visually presented referential information, including properties of referents relevant to specific actions, influences even the earliest moments of syntactic processing. Methodological concerns about task-specific strategies and the linking hypothesis between eye movements and linguistic processing are identified and discussed. These concerns are addressed in a review of recent studies of spoken word recognition which introduce and evaluate a detailed linking hypothesis between eye movements and lexical access. The results provide evidence about the time course of lexical activation that resolves some important theoretical issues in spoken-word recognition. They also demonstrate that fixations are sensitive to properties of the normal language-processing system that cannot be attributed to task-specific strategies

Abstract

This paper presents electrophysiological data on the on-line processing of open- and closed-class words in patients with Broca’s aphasia with agrammatic comprehension. Event-related brain potentials were recorded from the scalp when Broca patients and nonaphasic control subjects were visually presented with a story in which the words appeared one at a time on the screen. Separate waveforms were computed for open- and closed-class words. The non-aphasic control subjects showed clear differences between the processing of open- and closed-class words in an early (210-375 ms) and a late (400-700 ms) time-window.The early electrophysiological differences reflect the first manifestation of the availability of word-category information from the mental lexicon. The late differences presumably relate to post-lexical semantic and syntactic processing. In contrast to the control subjects, the Broca patients showed no early vocabulary class effect and only a limited late effect. The results suggest that an important factor in the agrammatic comprehension deficit of Broca’s aphasics is a delayed and/or incomplete availability of word-class information.

Abstract

In this paper we investigate acoustic differences between vowels in syllables that do or do not carry lexical stress. In doing so, we concentrated on segmental acoustic phonetic features that are conventionally assumed to differ between stressed and unstressed syllables, viz. Duration, Energy and Spectral Tilt. The speech material in this study differs from the type of material used in previous research: instead of specially constructed sentences we used phonetically rich sentences from the Dutch POLYPHONE corpus. Most of the Duration, Energy and Spectral Tilt features that we used in the investigation show statistically significant differences for the population means of stressed and unstressed vowels. However, it also appears that the distributions overlap to such an extent that automatic detection of stressed and unstressed syllables yields correct classifications of 72.6% at best. It is argued that this result is due to the large variety in the ways in which the abstract linguistic feature `lexical stress' is realized in the acoustic speech signal. Our findings suggest that a lexical stress detector has little use for a single pass decoder in an automatic speech recognition (ASR) system, but could still play a useful role as an additional knowledge source in a multi-pass decoder.

Abstract

An essential phenomenon in the development towards syntactic maturity after early childhood is the increasing use of so-called sentence-combining transformations. Especially by using subordination, complex sentences are produced. The research reported here is an attempt to arrive at a more adequate characterization and explanation. Our starting point was an analysis of 280 texts written by Dutch-speaking pupils of the two highest grades of the primary school and the four lowest grades of three different types of secondary education. It was examined whether systematic shifts in the use of certain groups of so-called function words could be traced. We concluded that the development of the syntactic formulating ability can be characterized as an increase in connectivity: the use of all kinds of function words which explicitly mark logico-semantic relations between propositions. This development starts by inserting special adverbs and coordinating conjunctions resulting in various types of coordination. In a later stage, the syntactic patterning of the sentence is affected as well (various types of subordination). The increase in sentence complexity is only one aspect of the entire development. An explanation for the increase in connectivity is offered based upon a distinction between narrative and expository language use. The latter, but not the former, is characterized by frequent occurrence of connectives. The development in syntactic formulating ability includes a high level of skill in expository language use. Speed of development is determined by intensity of training, e.g. in scholastic and occupational settings.