Publications

Abstract

In the Smaldino et al. study ‘Sigmoidal Acquisition Curves are Good Indicators of Conformist Transmission’, our original findings regarding the conditional validity of using population-level sigmoidal acquisition curves as means to evidence individual-level conformity are contested. We acknowledge the identification of useful nuances, yet conclude that our original findings remain relevant for the study of conformist learning mechanisms. Replying to: Smaldino, P. E., Aplin, L. M. & Farine, D. R. Sigmoidal Acquisition Curves Are Good Indicators of Conformist Transmission. Sci. Rep. 8, https://doi.org/10.1038/s41598-018-30248-5 (2018).

Abstract

Self-monitoring in production is critical to correct performance, and recent accounts suggest that such monitoring may occur via the detection of response conflict. The error-related negativity (ERN) is a response-locked event-related potential (ERP) that is sensitive to response conflict. The present study examines whether response conflict is detected in production by exploring a situation where multiple outputs are activated: the bilingual naming of form-related equivalents (i.e. cognates). ERPs were recorded while German-Dutch bilinguals named pictures in their first and second languages. Although cognates were named faster than non-cognates, response conflict was evident in the form of a larger ERN-like response for cognates and adaptation effects on naming, as the magnitude of cognate facilitation was smaller following the naming of cognates. Given that signals of response conflict are present during correct naming, the present results suggest that such conflict may serve as a reliable signal for monitoring in speech production.

Abstract

Verbal working memory (VWM), the ability to maintain and manipulate representations of speech sounds over short periods, is held by some influential models to be independent from the systems responsible for language production and comprehension [e.g., Baddeley, A. D. Working memory, thought, and action. New York, NY: Oxford University Press, 2007]. We explore the alternative hypothesis that maintenance in VWM is subserved by temporary activation of the language production system [Acheson, D. J., & MacDonald, M. C. Verbal working memory and language production: Common approaches to the serial ordering of verbal information. Psychological Bulletin, 135, 50–68, 2009b]. Specifically, we hypothesized that for stimuli lacking a semantic representation (e.g., nonwords such as mun), maintenance in VWM can be achieved by cycling information back and forth between the stages of phonological encoding and articulatory planning. First, fMRI was used to identify regions associated with two different stages of language production planning: the posterior superior temporal gyrus (pSTG) for phonological encoding (critical for VWM of nonwords) and the middle temporal gyrus (MTG) for lexical–semantic retrieval (not critical for VWM of nonwords). Next, in the same subjects, these regions were targeted with repetitive transcranial magnetic stimulation (rTMS) during language production and VWM task performance. Results showed that rTMS to the pSTG, but not the MTG, increased error rates on paced reading (a language production task) and on delayed serial recall of nonwords (a test of VWM). Performance on a lexical–semantic retrieval task (picture naming), in contrast, was significantly sensitive to rTMS of the MTG. Because rTMS was guided by language production-related activity, these results provide the first causal evidence that maintenance in VWM directly depends on the long-term representations and processes used in speech production.

Abstract

The influence of semantic processing on the serial ordering of items in short-term memory was explored using a novel dual-task paradigm. Participants engaged in 2 picture-judgment tasks while simultaneously performing delayed serial recall. List material varied in the presence of phonological overlap (Experiments 1 and 2) and in semantic content (concrete words in Experiment 1 and 3; nonwords in Experiments 2 and 3). Picture judgments varied in the extent to which they required accessing visual semantic information (i.e., semantic categorization and line orientation judgments). Results showed that, relative to line-orientation judgments, engaging in semantic categorization judgments increased the proportion of item-ordering errors for concrete lists but did not affect error proportions for nonword lists. Furthermore, although more ordering errors were observed for phonologically similar relative to dissimilar lists, no interactions were observed between the phonological overlap and picture-judgment task manipulations. These results demonstrate that lexical-semantic representations can affect the serial ordering of items in short-term memory. Furthermore, the dual-task paradigm provides a new method for examining when and how semantic representations affect memory performance.

Abstract

Research on written language comprehension has generally assumed that the phonological properties of a word have little effect on sentence comprehension beyond the processes of word recognition. Two experiments investigated this assumption. Participants silently read relative clauses in which two pairs of words either did or did not have a high degree of phonological overlap. Participants were slower reading and less accurate comprehending the overlap sentences compared to the non-overlapping controls, even though sentences were matched for plausibility and differed by only two words across overlap conditions. A comparison across experiments showed that the overlap effects were larger in the more difficult object relative than in subject relative sentences. The reading patterns showed that phonological representations affect not only memory for recently encountered sentences but also the developing sentence interpretation during on-line processing. Implications for theories of sentence processing and memory are discussed. Highlights The work investigates the role of phonological information in sentence comprehension, which is poorly understood. ► Subjects read object and subject relative clauses +/- phonological overlap in two pairs of words. ► Unique features of the study were online reading measures and pinpointed overlap locations. ► Phonological overlap slowed reading speed and impaired sentence comprehension, especially for object relatives. ► The results show a key role for phonological information during online comprehension, not just later sentence memory.

Abstract

A repetition-suppression functional magnetic resonance imaging paradigm was used to explore the neuroanatomical substrates of processing two types of acoustic variation—speaker and accent—during spoken sentence comprehension. Recordings were made for two speakers and two accents: Standard Dutch and a novel accent of Dutch. Each speaker produced sentences in both accents. Participants listened to two sentences presented in quick succession while their haemodynamic responses were recorded in an MR scanner. The first sentence was spoken in Standard Dutch; the second was spoken by the same or a different speaker and produced in Standard Dutch or in the artificial accent. This design made it possible to identify neural responses to a switch in speaker and accent independently. A switch in accent was associated with activations in predominantly left-lateralized areas including posterior temporal regions, including superior temporal gyrus, planum temporale (PT), and supramarginal gyrus, as well as in frontal regions, including left pars opercularis of the inferior frontal gyrus (IFG). A switch in speaker recruited a predominantly right-lateralized network, including middle frontal gyrus and prenuneus. It is concluded that posterior temporal areas, including PT, and frontal areas, including IFG, are involved in processing accent variation in spoken sentence comprehension

Abstract

We investigated how two distortions of the speech signal–added background noise and speech in an unfamiliar accent - affect comprehension of speech using functional Magnetic Resonance Imaging (fMRI). Listeners performed a speeded sentence verification task for speech in quiet in Standard Dutch, in Standard Dutch with added background noise, and for speech in an unfamiliar accent of Dutch. The behavioural results showed slower responses for both types of distortion compared to clear speech, and no difference between the two distortions. The neuroimaging results showed that, compared to clear speech, processing noise resulted in more activity bilaterally in Inferior Frontal Gyrus, Frontal Operculum, while processing accented speech recruited an area in left Superior Temporal Gyrus/Sulcus. It is concluded that the neural bases for processing different distortions of the speech signal dissociate. It is suggested that current models of the cortical organisation of speech are updated to specifically associate bilateral inferior frontal areas with processing external distortions (e.g., background noise) and left temporal areas with speaker-related distortions (e.g., accents).

Abstract

Ischemic stroke causes transient increase of neural stem and progenitor cell (NSPC) proliferation in the subventricular zone (SVZ), and migration of newly formed neuroblasts toward the damaged area where they mature to striatal neurons. The molecular mechanisms regulating this plastic response, probably involved in structural reorganization and functional recovery, are poorly understood. The adaptor protein LNK suppresses hematopoietic stem cell self-renewal, but its presence and role in the brain are poorly understood. Here we demonstrate that LNK is expressed in NSPCs in the adult mouse and human SVZ. Lnk−/− mice exhibited increased NSPC proliferation after stroke, but not in intact brain or following status epilepticus. Deletion of Lnk caused increased NSPC proliferation while overexpression decreased mitotic activity of these cells in vitro. We found that Lnk expression after stroke increased in SVZ through the transcription factors STAT1/3. LNK attenuated insulin-like growth factor 1 signaling by inhibition of AKT phosphorylation, resulting in reduced NSPC proliferation. Our findings identify LNK as a stroke-specific, endogenous negative regulator of NSPC proliferation, and suggest that LNK signaling is a novel mechanism influencing plastic responses in postischemic brain.

Abstract

Across many languages from unrelated families, spoken-word recognition is subject to a constraint whereby potential word candidates must contain a vowel. This constraint minimizes competition from embedded words (e.g., in English, disfavoring win in twin because t cannot be a word). However, the constraint would be counter-productive in certain languages that allow stand-alone vowelless open-class words. One such language is Berber (where t is indeed a word). Berber listeners here detected words affixed to nonsense contexts with or without vowels. Length effects seen in other languages replicated in Berber, but in contrast to prior findings, word detection was not hindered by vowelless contexts. When words can be vowelless, otherwise universal constraints disfavoring vowelless words do not feature in spoken-word recognition.

Abstract

In an influential paper (“Rule Learning by Seven-Month-Old Infants”), Marcus, Vijayan, Rao and Vishton claimed that connectionist models cannot account for human success at learning tasks that involved generalization of abstract knowledge such as grammatical rules. This claim triggered a heated debate, centered mostly around variants of the Simple Recurrent Network model. In our work, we revisit this unresolved debate and analyze the underlying issues from a different perspective. We argue that, in order to simulate human-like learning of grammatical rules, a neural network model should not be used as a tabula rasa, but rather, the initial wiring of the neural connections and the experience acquired prior to the actual task should be incorporated into the model. We present two methods that aim to provide such initial state: a manipulation of the initial connections of the network in a cognitively plausible manner (concretely, by implementing a “delay-line” memory), and a pre-training algorithm that incrementally challenges the network with novel stimuli. We implement such techniques in an Echo State Network (ESN), and we show that only when combining both techniques the ESN is able to learn truly general identity rules. Finally, we discuss the relation between these cognitively motivated techniques and recent advances in Deep Learning.

Abstract

At what point in the process of speech production is gesture involved? According to the Lexical Retrieval Hypothesis, gesture is involved in generating the surface forms of utterances. Specifically, gesture facilitates access to items in the mental lexicon. According to the Information Packaging Hypothesis, gesture is involved in the conceptual planning of messages. Specifically, gesture helps speakers to ''package'' spatial information into verbalisable units. We tested these hypotheses in 5-year-old children, using two tasks that required comparable lexical access, but different information packaging. In the explanation task, children explained why two items did or did not have the same quantity (Piagetian conservation). In the description task, children described how two items looked different. Children provided comparable verbal responses across tasks; thus, lexical access was comparable. However, the demands for information packaging differed. Participants' gestures also differed across the tasks. In the explanation task, children produced more gestures that conveyed perceptual dimensions of the objects, and more gestures that conveyed information that differed from the accompanying speech. The results suggest that gesture is involved in the conceptual planning of speech.

Abstract

The present paper assesses discourse-pragmatic factors as a potential explanation for the subject-object assymetry in early child language. It identifies a set of factors which characterize typical situations of informativeness (Greenfield & Smith, 1976), and uses these factors to identify informative arguments in data from four children aged 2;0 through 3;6 learning Inuktitut as a first language. In addition, it assesses the extent of the links between features of informativeness on one hand and lexical vs. null and subject vs. object arguments on the other. Results suggest that a pragmatics account of the subject-object asymmetry can be upheld to a greater extent than previous research indicates, and that several of the factors characterizing informativeness are good indicators of those arguments which tend to be omitted in early child language.

Abstract

Whilst certain verbs may appear in both the intransitive inchoative and the transitive causative constructions (The ball rolled/The man rolled the ball), others may appear in only the former (The man laughed/*The joke laughed the man). Some accounts argue that children acquire these restrictions using only (or mainly) statistical learning mechanisms such as entrenchment and pre-emption. Others have argued that verb semantics are also important. To test these competing accounts, adults (Experiment 1) and children aged 5–6 and 9–10 (Experiment 2) were taught novel verbs designed to be construed — on the basis of their semantics — as either intransitive-only or alternating. In support of the latter claim, participants' grammaticality judgments revealed that even the youngest group respected these semantic constraints. Frequency (entrenchment) effects were observed for familiar, but not novel, verbs (Experiment 1). We interpret these findings in the light of a new theoretical account designed to yield effects of both verb semantics and entrenchment/pre-emption.

Abstract

The present study investigated how children learn that some verbs may appear in the figure-locative but not the ground-locative construction (e.g., Lisa poured water into the cup; *Lisa poured the cup with water), with some showing the opposite pattern (e.g., *Bart filled water into the cup; Bart filled the cup with water), and others appearing in both (Lisa sprayed water onto the flowers; Lisa sprayed the flowers with water). Grammatical acceptability judgments were obtained for the use of each of 142 locative verbs (60 for children) in each sentence type. Overall, and for each age group individually, the judgment data were best explained by a model that included ratings of the extent to which each verb exhibits both the broad- and narrow-range semantic properties of the figure- and ground-locative constructions (relating mainly to manner and end-state respectively; Pinker, 1989) and the statistical-learning measure of overall verb frequency (entrenchment; Braine & Brooks, 1995). A second statistical-learning measure, frequency in each of the two locative constructions (pre-emption; Goldberg, 1995), was found to have no additional dissociable effect. We conclude by drawing together various theoretical proposals to arrive at a possible account of how semantics and statistics interact in the retreat from overgeneralization.

Abstract

Children (aged five-to-six and nine-to-ten years) and adults rated the acceptability of well-formed sentences and argument-structure overgeneralization errors involving the prepositional-object and double-object dative constructions (e.g. Marge pulled the box to Homer/*Marge pulled Homer the box). In support of the entrenchment hypothesis, a negative correlation was observed between verb frequency and the acceptability of errors, across all age groups. Adults additionally displayed sensitivity to narrow-range semantic constraints on the alternation, rejecting double-object dative uses of novel verbs consistent with prepositional-dative-only classes and vice versa. Adults also provided evidence for the psychological validity of a proposed morphophonological constraint prohibiting Latinate verbs from appearing in the double-object dative. These findings are interpreted in the light of a recent account of argument-structure acquisition, under which children retreat from error by incrementally learning the semantic, phonological, and pragmatic properties associated with particular verbs and particular construction slots.*

Abstract

his work offers a modern description of Ewe(GBE), a Kwa (Niger-Congo) language of West Africa. It assumes that the “essence of linguistics is the quest for meaning” (Whorf) and investigates the meanings of grammatical constructions and illocutionary devices representing them in Natural Semantic Metalanguage (NSM) style explications. The explications account for the range of use of the constructions suggested by data from diversified mediated discourse: television and radio interviews and drama, written plays and fiction as well as insider knowledge of and observed behaviour both as participant and observer in Ewe communities of practice. The author draws ecumenically on insights from functional and formal linguistic approaches. The work opens with an overview of Ewe structural grammar. The rest of the work is divided into three parts. Part II concentrates on property denoting expressions, imperfective aspect constructions and possession. Part III examines the grammatical resources available to the Ewe speaker for packaging information in a clause: scene-setting constructions, a “capability passive” construction and experiential constructions. In Part IV illocutionary devices such as formulaic and routine expressions, address terms and interjections are described paying attention to their socio-cultural dimensions of use. This work is of interest to Africanists and linguists interested in grammatical description, typology, semantics and pragmatics as well as anthropologists interested in ethnography of communication and the relation between language and culture.

Abstract

Particles are little words that speakers use to signal the illocutionary force of utterances and/or express their attitude towards elements of the communicative situation, e.g. the addresses. This paper presents an overview of the classification, meaning and use of utterance particles in Ewe. It argues that they constitute a grammatical word class on functional and distributional grounds. The paper calls for a cross-cultural investigation of particles, especially in Africa, where they have been neglected for far too long.

Abstract

How do different languages encode location and position meanings? In conjunction with the BowPed picture series and Caused Positions task, this elicitation tool is designed to help researchers (i) identify a language’s resources for encoding topological relations; (ii) delimit the pragmatics of use of such resources; and (iii) determine the semantics of select spatial terms. The task focuses on the exploration of the predicative component of topological expressions (e.g., ‘the cassavas are lying in the basket’), especially the contrastive elicitation of positional verbs. The materials consist of a set of photographs of objects (e.g., bottles, cloths, sticks) in specific configurations with various ground items (e.g., basket, table, tree).

Abstract

This paper presents the linguistic means of describing spatial relations in Ewe with particular emphasis on the grammar and meaning of adpositions. Ewe ( N iger-Congo ) has two sets of adpositions: prepositions, which have evolvedfrom verbs, and postpositions which have evolvedfrom nouns. The postpositions create places and are treated äs intrinsic parts or regions of the reference object in a spatial description. The prepositions provide the general orientation of a Figure (located object). It is demonstrated (hat spaiial relations, such äs those encapsulated in "the basic topological prepositions at, in and on" in English (Herskovits 1986: 9), are not encoded in single linguistic elements in Ewe, but are distributed over members of dijferent form classes in a syntagmatic string, The paper explores the r öle of compositionality andits interaction with pragmatics to yield understandings of spatial configurations in such a language where spatial meanings cannot he simply read off one form. The study also examines the diversity among languages in terms of the nature and obligatoriness of the coding of relational and ground Information in spatial constructions. It is argued that the ränge and type of distinctions discussed in the paper must be accountedfor in semantic typology and in the cross-linguistic investigation of spatial language and conceptualisation.

Abstract

The purpose of this paper is to investigate the meanings of the members of two subclasses of interjections in Ewe: the conative/volitive which are directed at an auditor, and the phatic which are used in the maintenance of social and communicative contact. It is demonstrated that interjections like other linguistic signs have meanings which can be rigorously stated. In addition, the paper explores the differences and similarities between the semantic structures of interjections on one hand and formulaic words on the other. This is done through a comparison of the semantics and pragmatics of an interjection and a formulaic word which are used for welcoming people in Ewe. It is contended that formulaic words are speech acts qua speech acts while interjections are not fully fledged speech acts because they lack illocutionary dictum in their semantic structure.

Abstract

Most work on part-of-speech (POS) tagging is focused on high resource languages, or examines low-resource and active learning settings through simulated studies. We evaluate POS tagging techniques on an actual endangered language, Griko. We present a resource that contains 114 narratives in Griko, along with sentence-level translations in Italian, and provides gold annotations for the test set. Based on a previously collected small corpus, we investigate several traditional methods, as well as methods that take advantage of monolingual data or project cross-lingual POS tags. We show that the combination of a semi-supervised method with cross-lingual transfer is more appropriate for this extremely challenging setting, with the best tagger achieving an accuracy of 72.9%. With an applied active learning scheme, which we use to collect sentence-level annotations over the test set, we achieve improvements of more than 21 percentage points

Abstract

This paper explores the role of various types of location control in descriptions of placement events in Hungarian. It will be shown that general verb choices cannot be explained in terms of spatial relations (such as containment and support) or spatial relational changes (such as joining and separation). On the contrary, all main verb distinctions within the placement domain can be described in terms of agentive control settings between the Figure and agentive entities (e.g., the Agent, other persons). In Hungarian, only events with continuous agentive control along the motion trajectory are described as either ‘putting’ or ‘taking’, and only events where the Figure is furthermore controlled by a non-agentive entity at the Goal are described as ‘putting’.

Abstract

The current study investigated which time components of rapid automatized naming (RAN) predict group differences between dyslexic and non-dyslexic readers (matched for age and reading level), and how these components relate to different reading measures. Subjects performed two RAN tasks (letters and objects), and data were analyzed through a response time analysis. Our results demonstrated that impaired RAN performance in dyslexic readers mainly stem from enhanced inter-item pause times and not from difficulties at the level of post-access motor production (expressed as articulation rates). Moreover, inter-item pause times account for a significant proportion of variance in reading ability in addition to the effect of phonological awareness in the dyslexic group. This suggests that non-phonological factors may lie at the root of the association between RAN inter-item pauses and reading ability. In normal readers, RAN performance was associated with reading ability only at early ages (i.e. in the reading-matched controls), and again it was the RAN inter-item pause times that explain the association.

Abstract

In this study, event related potentials (ERPs) were used to investigate the extent to which dyslexics (aged 9–13 years) differ from normally reading controls in early ERPs, which reflect prelexical orthographic processing, and in late ERPs, which reflect implicit phonological processing. The participants performed an implicit reading task, which was manipulated in terms of letter-specific processing, orthographic familiarity, and phonological structure. Comparing consonant- and symbol sequences, the results showed significant differences in the P1 and N1 waveforms in the control but not in the dyslexic group. The reduced P1 and N1 effects in pre-adolescent children with dyslexia suggest a lack of visual specialization for letter-processing. The P1 and N1 components were not sensitive to the familiar vs. less familiar orthographic sequence contrast. The amplitude of the later N320 component was larger for phonologically legal (pseudowords) compared to illegal (consonant sequences) items in both controls and dyslexics. However, the topographic differences showed that the controls were more left-lateralized than the dyslexics. We suggest that the development of the mechanisms that support literacy skills in dyslexics is both delayed and follows a non-normal developmental path. This contributes to the hemispheric differences observed and might reflect a compensatory mechanism in dyslexics.

Abstract

In the present study, the authors investigate how some visual factors related to early stages of visual-object naming modulate naming performance in dyslexia. The performance of dyslexic children was compared with 2 control groups—normal readers matched for age and normal readers matched for reading level—while performing a discrete naming task in which color and dimensionality of the visually presented objects were manipulated. The results showed that 2-dimensional naming performance improved for color representations in control readers but not in dyslexics. In contrast to control readers, dyslexics were also insensitive to the stimulus's dimensionality. These findings are unlikely to be explained by a phonological processing problem related to phonological access or retrieval but suggest that dyslexics have a lower capacity for coding and decoding visual surface features of 2-dimensional representations or problems with the integration of visual information stored in long-term memory.

Abstract

This article summarizes some of the important findings from research evaluating the relationship between poor rapid naming and impaired reading performance. Substantial evidence shows that dyslexic readers have problems with rapid naming of visual items. Early research assumed that this was a consequence of phonological processing deficits, but recent findings suggest that non-phonological processes may lie at the root of the association between slow naming speed and poor reading. The hypothesis that rapid naming reflects an independent core deficit in dyslexia is supported by the main findings: (1) some dyslexics are characterized by rapid naming difficulties but intact phonological skills; (2) evidence for an independent association between rapid naming and reading competence in the dyslexic readers, when the effect of phonological skills was controlled; (3) rapid naming and phonological processing measures are not reliably correlated. Recent research also reveals greater predictive power of rapid naming, in particular the inter-item pause time, for high-frequency word reading compared to pseudoword reading in developmental dyslexia. Altogether, the results are more consistent with the view that a phonological component alone cannot account for the rapid naming performance in dyslexia. Rather, rapid naming problems may emerge from the inefficiencies in visual-orthographic processing as well as in phonological processing.

Abstract

The RELISH project promotes language-oriented research by addressing a two-pronged problem: (1) the lack of harmonization between digital standards for lexical information in Europe and America, and (2) the lack of interoperability among existing lexicons of endangered languages, in particular those created with the Shoebox/Toolbox lexicon building software. The cooperation partners in the RELISH project are the University of Frankfurt (FRA), the Max Planck Institute for Psycholinguistics (MPI Nijmegen), and Eastern Michigan University, the host of the Linguist List (ILIT). The project aims at harmonizing key European and American digital standards whose divergence has hitherto impeded international collaboration on language technology for resource creation and analysis, as well as web services for archive access. Focusing on several lexicons of endangered languages, the project will establish a unified way of referencing lexicon structure and linguistic concepts, and develop a procedure for migrating these heterogeneous lexicons to a standards-compliant format. Once developed, the procedure will be generalizable to the large store of lexical resources involved in the LEGO and DoBeS projects.

Abstract

In mammals, respiratory-locked hippocampal rhythms are implicated in the scaffolding and transfer of information between sensory and memory networks. These oscillations are entrained by nasal respiration and driven by the olfactory bulb. They then travel to the piriform cortex where they propagate further downstream to the hippocampus and modulate neural processes critical for memory formation. In humans, bypassing nasal airflow through mouth-breathing abolishes these rhythms and impacts encoding as well as recognition processes thereby reducing memory performance. It has been hypothesized that similar behavior should be observed for the consolidation process, the stage between encoding and recognition, were memory is reactivated and strengthened. However, direct evidence for such an effect is lacking in human and non-human animals. Here we tested this hypothesis by examining the effect of respiration on consolidation of episodic odor memory. In two separate sessions, female and male participants encoded odors followed by a one hour awake resting consolidation phase where they either breathed solely through their nose or mouth. Immediately after the consolidation phase, memory for odors was tested. Recognition memory significantly increased during nasal respiration compared to mouth respiration during consolidation. These results provide the first evidence that respiration directly impacts consolidation of episodic events, and lends further support to the notion that core cognitive functions are modulated by the respiratory cycle.

Abstract

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

Abstract

The efficacy of cardiac repair by stem cell administration relies on a successful functional integration of injected cells into the host myocardium. Safety concerns have been raised about the possibility that stem cells may induce foci of arrhythmia in the ischemic myocardium. In a previous work (36), we showed that human cord blood CD34+ cells, when cocultured on neonatal mouse cardiomyocytes, exhibit excitation-contraction coupling features similar to those of cardiomyocytes, even though no human genes were upregulated. The aims of the present work are to investigate whether human CD34+ cells, isolated after 1 wk of coculture with neonatal ventricular myocytes, possess molecular and functional properties of cardiomyocytes and to discriminate, using a reporter gene system, whether cardiac differentiation derives from a (trans)differentiation or a cell fusion process. Umbilical cord blood CD34+ cells were isolated by a magnetic cell sorting method, transduced with a lentiviral vector carrying the enhanced green fluorescent protein (EGFP) gene, and seeded onto primary cultures of spontaneously beating rat neonatal cardiomyocytes. Cocultured EGFP+/CD34+-derived cells were analyzed for their electrophysiological features at different time points. After 1 wk in coculture, EGFP+ cells, in contact with cardiomyocytes, were spontaneously contracting and had a maximum diastolic potential (MDP) of −53.1 mV, while those that remained isolated from the surrounding myocytes did not contract and had a depolarized resting potential of −11.4 mV. Cells were then resuspended and cultured at low density to identify EGFP+ progenitor cell derivatives. Under these conditions, we observed single EGFP+ beating cells that had acquired an hyperpolarization-activated current typical of neonatal cardiomyocytes (EGFP+ cells, −2.24 ± 0.89 pA/pF; myocytes, −1.99 ± 0.63 pA/pF, at −125 mV). To discriminate between cell autonomous differentiation and fusion, EGFP+/CD34+ cells were cocultured with cardiac myocytes infected with a red fluorescence protein-lentiviral vector; under these conditions we found that 100% of EGFP+ cells were also red fluorescent protein positive, suggesting cell fusion as the mechanism by which cardiac functional features are acquired.

Abstract

Understanding a word in context relies on a cascade of perceptual and conceptual processes, starting with modality-specific input decoding, and leading to the unification of the word's meaning into a discourse model. One critical cognitive event, turning a sensory stimulus into a meaningful linguistic sign, is the access of a semantic representation from memory. Little is known about the changes that activating a word's meaning brings about in cortical dynamics. We recorded the electroencephalogram (EEG) while participants read sentences that could contain a contextually unexpected word, such as ‘cold’ in ‘In July it is very cold outside’. We reconstructed trajectories in phase space from single-trial EEG time series, and we applied three nonlinear measures of predictability and complexity to each side of the semantic access boundary, estimated as the onset time of the N400 effect evoked by critical words. Relative to controls, unexpected words were associated with larger prediction errors preceding the onset of the N400. Accessing the meaning of such words produced a phase transition to lower entropy states, in which cortical processing becomes more predictable and more regular. Our study sheds new light on the dynamics of information flow through interfaces between sensory and memory systems during language processing.

Abstract

This chapter provides a partial overview of some currently debated issues in the cognitive science of language. We distinguish two families of problems, which we refer to as ‘language and cognition’ and ‘linguistics and cognition’. Under the first heading we present and discuss the hypothesis that language, in particular the semantics of tense and aspect, is grounded in the planning system. We emphasize the role of non-monotonic inference during language comprehension. We look at the converse issue of the role of linguistic interpretation in reasoning tasks. Under the second heading we investigate the two foremost assumptions of current linguistic methodology, namely intuitions as the only adequate empirical basis of theories of meaning and grammar and the competence-performance distinction, arguing that these are among the heaviest burdens for a truly comprehensive approach to language. Marr’s three-level scheme is proposed as an alternative methodological framework, which we apply in a review of two ERP studies on semantic processing, to the ‘binding problem’ for language, and in a conclusive set of remarks on relating theories in the cognitive science of language.

Abstract

At least three cognitive brain components are necessary in order for us to be able to produce and comprehend language: a Memory repository for the lexicon, a Unification buffer where lexical information is combined into novel structures, and a Control apparatus presiding over executive function in language. Here we describe the brain networks that support Memory and Unification in semantics. A dynamic account of their interactions is presented, in which a balance between the two components is sought at each word-processing step. We use the theory to provide an explanation of the N400 effect.

Abstract

The way the brain binds together words to form sentences may depend on whether and how the arising cognitive representation is to be used in behavior. The amplitude of the N400 effect in event-related brain potentials is inversely correlated with the degree of fit of a word's meaning into a semantic representation of the preceding discourse. This study reports a double dissociation in the latency characteristics of the N400 effect depending on task demands. When participants silently read words in a sentence context, without issuing a relevant overt response, greater temporal alignment over recording sites occurs for N400 onsets than peaks. If however a behavior is produced – here pressing a button in a binary probe selection task – exactly the opposite pattern is observed, with stronger alignment of N400 peaks than onsets. The peak amplitude of the N400 effect correlates best with the latency characteristic showing less temporal dispersion. These findings suggest that meaning construction in the brain is subtly affected by task demands, and that there is complex functional integration between semantic combinatorics and control systems handling behavioral goals.

Abstract

Autism is characterized by impairments in reciprocal social interaction and communication, and restricted and sterotyped patterns of interests and activities. Developmental difficulties are apparent before 3 years of age and there is evidence for strong genetic influences most likely involving more than one susceptibility gene. A two-stage genome search for susceptibility loci in autism was performed on 87 affected sib pairs plus 12 non-sib affected relative-pairs, from a total of 99 families identified by an international consortium. Regions on six chromosomes (4, 7, 10, 16, 19 and 22) were identified which generated a multipoint maximum lod score (MLS) > 1. A region on chromosome 7q was the most significant with an MLS of 3.55 near markers D7S530 and D7S684 in the subset of 56 UK affected sib-pair families, and an MLS of 2.53 in all 87 affected sib-pair families. An area on chromosome 16p near the telomere was the next most significant, with an MLS of 1.97 in the UK families, and 1.51 in all families. These results are an important step towards identifying genes predisposing to autism; establishing their general applicability requires further study.

Abstract

Like many other types of memory formation, novel word learning benefits from an offline consolidation period after the initial encoding phase. A previous EEG study has shown that retrieval of novel words elicited more word-like-induced electrophysiological brain activity in the theta band after consolidation [Bakker, I., Takashima, A., van Hell, J. G., Janzen, G., & McQueen, J. M. Changes in theta and beta oscillations as signatures of novel word consolidation. Journal of Cognitive Neuroscience, 27, 1286–1297, 2015]. This suggests that theta-band oscillations play a role in lexicalization, but it has not been demonstrated that this effect is directly caused by the formation of lexical representations. This study used magnetoencephalography to localize the theta consolidation effect to the left posterior middle temporal gyrus (pMTG), a region known to be involved in lexical storage. Both untrained novel words and words learned immediately before test elicited lower theta power during retrieval than existing words in this region. After a 24-hr consolidation period, the difference between novel and existing words decreased significantly, most strongly in the left pMTG. The magnitude of the decrease after consolidation correlated with an increase in behavioral competition effects between novel words and existing words with similar spelling, reflecting functional integration into the mental lexicon. These results thus provide new evidence that consolidation aids the development of lexical representations mediated by the left pMTG. Theta synchronization may enable lexical access by facilitating the simultaneous activation of distributed semantic, phonological, and orthographic representations that are bound together in the pMTG.

Abstract

Mouthings and mouth gestures are omnipresent in Sign Language of the Netherlands (NGT). Mouthings in NGT commonly have their origin in spoken Dutch. We conducted a corpus study to explore how frequent mouthings in fact are in NGT, whether there is variation within and between signs in mouthings, and how frequent temporal reduction occurs in mouthings. Answers to these questions can help us classify mouthings as being specified in the sign lexicon or as being instances of code-blending. We investigated a sample of 20 frequently occurring signs. We found that each sign in the sample co-occurs frequently with a mouthing, usually that of a specific Dutch lexical item. On the other hand, signs show variation in the way they co-occur with mouthings and mouth gestures. By using a relatively large amount of natural data, we succeeded in gaining more insight into the way mouth actions are utilized in sign languages.

Abstract

In conversation, listeners frequently encounter speakers with foreign accents. Previous research on foreign-accented speech has primarily examined the short-term effects of exposure and the relative ease that listeners have with adapting to an accent. The present study examines the stability of this adaptation, with seven full days between testing sessions. On both days, subjects performed a cross-modal priming task in which they heard several minutes of an unfamiliar accent of their native language: a form of Hebrewaccented Dutch in which long /i:/ was shortened to /I/. During this task on Day 1, recognition of accented forms was not facilitated, compared to that of canonical forms. A week later, when tested on new words, facilitatory priming occurred, comparable to that seen for canonically produced items tested in both sessions. These results suggest that accented forms can be learned from brief exposure and the stable effects of this can be seen a week later.

Abstract

Measurement bias is defined as a violation of measurement invariance, which can be investigated through multigroup factor analysis (MGFA), by testing across-group differences in intercepts (uniform bias) and factor loadings (nonuniform bias). Restricted factor analysis (RFA) can also be used to detect measurement bias. To also enable nonuniform bias detection, we extend RFA with latent moderated structures (LMS) or use a random slope parameterization (RSP). In a simulation study we compare the MGFA, RFA/LMS, and RFA/RSP methods in detecting measurement bias, varying type of bias (uniform, nonuniform), type of the variable that violates measurement invariance (dichotomous, continuous), and its relationship with the trait that we want to measure (independent, dependent). For each condition, 500 sets of data are generated and analyzed with each of the three detection methods, in single run and in an iterative procedure. The RFA methods outperform MGFA when the violating variable is continuous.

Abstract

Objectives: A problem with the topographic mapping of MEG data recorded with axial gradiometers is that field extrema are measured at sensors located at either side of a neuronal generator instead of at sensors directly above the source. This is problematic for the computation of event-related desynchronization (ERD) on MEG data, since ERD relies on a correspondence between the signal maximum and the location of the neuronal generator. Methods: We present a new method based on computing spatial derivatives of the MEG data. The limitations of this method were investigated by means of forward simulations, and the method was applied to a 150-channel MEG dataset. Results: The simulations showed that the method has some limitations. (1) Fewer channels reduce accuracy and amplitude. (2) It is less suitable for deep or very extended sources. (3) Multiple sources can only be distinguished if they are not too close to each other. Applying the method in the calculation of ERD on experimental data led to a considerable improvement of the ERD maps. Conclusions: The proposed method offers a significant advantage over raw MEG signals, both for the topographic mapping of MEG and for the analysis of rhythmic MEG activity by means of ERD.

Abstract

In the present paper, event-related desynchronization (ERD) in the alpha and beta frequency bands is quantified in order to investigate the processes related to the anticipation of a knowledge of results (KR) stimulus. In a time estimation task, 10 subjects were instructed to press a button 4 s after the presentation of an auditory stimulus. Two seconds after the response they received auditory or visual feedback on the timing of their response. Preceding the button press, a centrally maximal ERD is found. Preceding the visual KR stimulus, an ERD is present that has an occipital maximum. Contrary to expectation, preceding the auditory KR stimulus there are no signs of a modalityspecific ERD. Results are related to a thalamo-cortical gating model which predicts a correspondence between negative slow potentials and ERD during motor preparation and stimulus anticipation.

Abstract

Several grammatical features in early Indo-European traditionally have not been understood. Although Latin, for example, was a nominative language, a number of its inherited characteristics do not fit that typology and are difficult to account for, such as stative mihi est constructions to express possession, impersonal verbs, or absolute constructions. With time these archaic features have been replaced by transitive structures (e.g. possessive ‘have’). This book presents an extensive comparative and historical analysis of archaic features in early Indo-European languages and their gradual replacement in the history of Latin and early Romance, showing that the new structures feature transitive syntax and fit the patterns of a nominative language.

Abstract

Analysis of the functions of nominal apposition in a number of Latin authors representing different periods, genres, and
linguistic registers shows (1) that nominal apposition in Latin had a wide variety of functions; (2) that genre had some
effect on functional use; (3) that change did not affect semantic fields as such; and (4) that with time the occurrence of
apposition increasingly came to depend on the semantic field and within the semantic field on the individual lexical items.
The ‘per-word’ treatment –also attested for the structural development of nominal apposition– underscores the specific
characteristics of nominal apposition as a phenomenon at the cross-roads of syntax and derivational morphology

Abstract

Managing Director of the Max Planck Institute for Psycholinguistics, founding Director of the Donders Centre for Cognitive Neuroimaging (DCCN, 1999), and professor of Cognitive Neuroscience at Radboud University, all located in Nijmegen, the Netherlands, PETER HAGOORT examines how the brain controls language production and comprehension. He was one of the first to integrate psychological theory and models from neuroscience in an attempt to understand how the human language faculty is instantiated in the brain.

Abstract

This book examines Latin word order, its historical origins in Proto-Indo-European and the shift in ordering patterns that took place in syntax and morphology in the history of Latin and (early) French (OV or left branching giving way to VO or right branching). Subsequently, analysis of the acquisition of ordering patterns shows that the archaic structuration—when complex—is acquired with difficulty. Diachronic and psycholinguistic analysis therefore demonstrates that the order of grammatical structures in Modern French, for example, is the result of a long-lasting development that psycholinguistic data can account for.

Abstract

Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a molecular window into the neurobiology of language. Individuals with FOXP2 mutations have structural and functional alterations affecting brain circuits that overlap with sites of FOXP2 expression, including regions of the cortex, striatum, and cerebellum. FOXP2 displays complex patterns of expression in the brain, as well as in non-neuronal tissues, suggesting that sophisticated regulatory mechanisms control its spatio-temporal expression. However, to date, little is known about the regulation of FOXP2 or the genomic elements that control its expression. Using chromatin conformation capture (3C), we mapped the human FOXP2 locus to identify putative enhancer regions that engage in long-range interactions with the promoter of this gene. We demonstrate the ability of the identified enhancer regions to drive gene expression. We also show regulation of the FOXP2 promoter and enhancer regions by candidate regulators – FOXP family and TBR1 transcription factors. These data point to regulatory elements that may contribute to the temporal- or tissue-specific expression patterns of human FOXP2. Understanding the upstream regulatory pathways controlling FOXP2 expression will bring new insight into the molecular networks contributing to human language and related disorders.

Abstract

The current paper proposes a frame-based account to conceptual shifts in the countability do-main. We interpret shifts in noun countability as syntactically driven metonymy. Inserting a noun in an incongruent noun phrase, that is combining it with a determiner of the other countability class, gives rise to a re-interpretation of the noun referent. We assume lexical entries to be three-fold frame com-plexes connecting conceptual knowledge representations with language-specific form representations via a lemma level. Empirical data from a lexical decision experiment are presented, that support the as-sumption of such a lemma level connecting perceptual input of linguistic signs to conceptual knowledge.

Abstract

This study explored whether infants aged 12 months already recognize the communicative function of pointing gestures. Infants participated in a task requiring them to comprehend an adult’s informative pointing gesture to the location of a hidden toy. They mostly succeeded in this task, which required them to infer that the adult was attempting to direct their attention to a location for a reason – because she wanted them to know that a toy was hidden there. Many of the infants also reversed roles and produced appropriate pointing gestures for the adult in this same game, and indeed there was a correlation such that comprehenders were for the most part producers. These findings indicate that by 12 months of age infants are beginning to show a bidirectional understanding of communicative pointing.

Abstract

In recent years, it has been suggested that social robots have potential as tutors and educators for both children and adults. While robots have been shown to be effective in teaching knowledge and skill-based topics, we wish to explore how social robots can be used to tutor a second language to young children. As language learning relies on situated, grounded and social learning, in which interaction and repeated practice are central, social robots hold promise as educational tools for supporting second language learning. This paper surveys the developmental psychology of second language learning and suggests an agenda to study how core concepts of second language learning can be taught by a social robot. It suggests guidelines for designing robot tutors based on observations of second language learning in human–human scenarios, various technical aspects and early studies regarding the effectiveness of social robots as second language tutors.

Abstract

In an investigation of contextual influences on sound categorization, 64 Peruvian Spanish listeners categorized vowels on an /i/ to /e/ continuum. First, to measure the influence of the stimulus range (broad acoustic context) and the preceding stimuli (local acoustic context), listeners were presented with different subsets of the Spanish /i/-/e/ continuum in separate blocks. Second, the influence of the number of response categories was measured by presenting half of the participants with /i/ and /e/ as responses, and the other half with /i/, /e/, /a/, /o/, and /u/. The results showed that the perceptual category boundary between /i/ and /e/ shifted depending on the stimulus range and that the formant values of locally preceding items had a contrastive influence. Categorization was less susceptible to broad and local acoustic context effects, however, when listeners were presented with five rather than two response options. Vowel categorization depends not only on the acoustic properties of the target stimulus, but also on its broad and local acoustic context. The influence of such context is in turn affected by the number of internal referents that are available to the listener in a task.

Abstract

There are more than 7,000 languages spoken in the world today1. It has been argued that the natural and social environment of languages drives this diversity. However, a fundamental question is how strong are environmental pressures, and does neutral drift suffice as a mechanism to explain diversification? We estimate the phylogenetic signals of geographic dimensions, distance to water, climate and population size on more than 6,000 phylogenetic trees of 46 language families. Phylogenetic signals of environmental factors are generally stronger than expected under the null hypothesis of no relationship with the shape of family trees. Importantly, they are also—in most cases—not compatible with neutral drift models of constant-rate change across the family tree branches. Our results suggest that language diversification is driven by further adaptive and non-adaptive pressures. Language diversity cannot be understood without modelling the pressures that physical, ecological and social factors exert on language users in different environments across the globe.

Abstract

The study of first language acquisition still strongly relies on behavioural methods to measure underlying linguistic abilities. In the present paper, we closely examine and model one such method, the headturn preference procedure (HPP), which is widely used to measure infant speech segmentation and word recognition abilities Our model takes real speech as input, and only uses basic sensory processing and cognitive capabilities to simulate observable behaviour.We show that the familiarity effect found in many HPP experiments can be simulated without using the phonetic and phonological skills necessary for segmenting test sentences into words. The explicit modelling of the process that converts the result of the cognitive processing of the test sentences into observable behaviour uncovered two issues that can lead to null-results in HPP studies. Our simulations show that caution is needed in making inferences about underlying language skills from behaviour in HPP experiments. The simulations also generated questions that must be addressed in future HPP studies.

Abstract

Both quality and quantity of speech from the primary caregiver have been found to impact language development. A third aspect of the input has been largely ignored: the number of talkers who provide input. Some infants spend most of their waking time with only one person; others hear many different talkers. Even if the very same words are spoken the same number of times, the pronunciations can be more variable when several talkers pronounce them. Is language acquisition affected by the number of people who provide input? To shed light on the possible link between how many people provide input in daily life and infants’ native vowel discrimination, three age groups were tested: 4-month-olds (before attunement to native vowels), 6-month-olds (at the cusp of native vowel attunement) and 12-month-olds (well attuned to the native vowel system). No relationship was found between talker number and native vowel discrimination skills in 4- and 6-month-olds, who are overall able to discriminate the vowel contrast. At 12 months, we observe a small positive relationship, but further analyses reveal that the data are also compatible with the null hypothesis of no relationship. Implications in the context of infant language acquisition and cognitive development are discussed.

Abstract

In the present paper we investigate the effect of categorising raw behavioural data or computational model responses. In addition, the effect of averaging over stimuli from potentially different populations is assessed. To this end, we replicate studies on word learning and generalisation abilities using the ACORNS models. Our results show that discrete categories may obscure interesting phenomena in the continuous responses. For example, the finding that learning in the model saturates very early at a uniform high recognition accuracy only holds for categorical representations. Additionally, a large difference in the accuracy for individual words is obscured by averaging over all stimuli. Because different words behaved differently for different speakers, we could not identify a phonetic basis for the differences. Implications and new predictions for infant behaviour are discussed.

Abstract

Pronouns seem to be acquired in an asymmetrical way, where children confuse the meaning of pronouns with reflexives up to the age of six, but not vice versa. Children’s production of the same referential expressions is appropriate at the age of four. However, response-based tasks, the usual means to investigate child language comprehension, are very demanding given children’s limited cognitive resources. Therefore, they might affect performance. To assess the impact of the task, we investigated learners of Dutch (three- and four-year-olds) using both eye-tracking, a non-demanding on-line method, and a typical response-based task. Eye-tracking results show an emerging ability to correctly comprehend pronouns at the age of four. A response-based task fails to indicate this ability across age groups, replicating results of earlier studies. Additionally, biases seem to influence the outcome of the response-based task. These results add new evidence to the ongoing debate of the asymmetrical acquisition of pronouns and reflexives and suggest that there is less of an asymmetry than previously assumed.

Abstract

Previous work suggests key factors for replicability, a necessary feature for theory
building, include statistical power and appropriate research planning. These factors are examined by analyzing a collection of 12 standardized meta-analyses on language development between birth and 5 years. With a median effect size of Cohen's d= 0.45 and typical sample size of 18 participants, most research is underpowered (range: 6%-99%;
median 44%); and calculating power based on seminal publications is not a suitable strategy.
Method choice can be improved, as shown in analyses on exclusion rates and effect size as a
function of method. The article ends with a discussion on how to increase replicability in both language acquisition studies specifically and developmental research more generally.

Abstract

In the present paper we investigate the effect of categorising raw behavioural data or computational model responses. In addition, the effect of averaging over stimuli from potentially different populations is assessed. To this end, we replicate studies on word learning and generalisation abilities using the ACORNS models. Our results show that discrete
categories may obscure interesting phenomena in the continuous
responses. For example, the finding that learning in the model saturates very early at a uniform high recognition accuracy only holds for categorical representations. Additionally, a large difference in the accuracy for individual words is obscured
by averaging over all stimuli. Because different words behaved
differently for different speakers, we could not identify a phonetic
basis for the differences. Implications and new predictions for
infant behaviour are discussed.

Abstract

Memory reprocessing following acquisition enhances memory consolidation. Specifically, neural activity during encoding is thought to be ‘replayed’ during subsequent slow-wave sleep. Such memory replay is thought to contribute to the functional reorganization of neural memory traces. In particular, memory replay may facilitate the exchange of information across brain regions by inducing a reconfiguration of connectivity across the brain. Memory reactivation can be induced by external cues through a procedure known as “targeted memory reactivation”. Here, we analysed data from a published study with auditory cues used to reactivate visual object-location memories during slow-wave sleep. We characterized effects of memory reactivation on brain network connectivity using graph-theory. We found that cue presentation during slow-wave sleep increased global network integration of occipital cortex, a visual region that was also active during retrieval of object locations. Although cueing did not have an overall beneficial effect on the retention of cued versus uncued associations, individual differences in overnight memory stabilization were related to enhanced network integration of occipital cortex. Furthermore, occipital cortex displayed enhanced connectivity with mnemonic regions, namely the hippocampus, parahippocampal gyrus, thalamus and medial prefrontal cortex during cue sound presentation. Together, these results suggest a neural mechanism where cue-induced replay during sleep increases integration of task-relevant perceptual regions with mnemonic regions. This cross-regional integration may be instrumental for the consolidation and long-term storage of enduring memories.

Abstract

In this chapter, the multilingual systems of bilingual speakers of Sursilvan Romansh and German are analyzed. The Romansh and the German systems show important differences in the domain of placement. Romansh has a fairly general verb metter ‘to put’ whereas German uses different verbs (e.g., setzen ‘to set’, legen ‘to lay’, stellen ‘to stand’). Whereas there are almost no traces of German in the Romansh data elicited from the German-Romansh bilinguals, it appears that their production of German yields uses of the verbs which differ from the typical German system. Although the forms of the German verbs have been acquired by the bilingual speakers, their distribution in the data arguably reflects traces of the Romansh category of metter ‘to put’.

Abstract

In two experiments, we studied the role of frequency information in the production of deverbal adjectives and inflected verbs in Dutch. Naming latencies were triggered in a position-response association task and analysed using stepwise mixed-effects modelling, with subject and word as crossed random effects. The production latency of deverbal adjectives was affected by the cumulative frequencies of their verbal stems, arguing for decomposition and against full listing. However, for the inflected verbs, there was an inhibitory effect of Inflectional Entropy, and a nonlinear effect of Lemma Frequency. Additional effects of Position-specific Neighbourhood Density and Cohort Entropy in both types of words underline the importance of paradigmatic relations in the mental lexicon. Taken together, the data suggest that the word-form level does neither contain full forms nor strictly separated morphemes, but rather morphemes with links to phonologically andin case of inflected verbsmorphologically related word forms.

Abstract

Crossmodal binding usually relies on bottom-up stimulus characteristics such as spatial and temporal correspondence. However, in case of ambiguity the brain has to decide whether to combine or segregate sensory inputs. We hypothesise that widespread, subtle forms of synesthesia provide crossmodal mapping patterns which underlie and influence multisensory perception. Our aim was to investigate if such a mechanism plays a role in the case of pitch-size stimulus combinations. Using a combination of psychophysics and ERPs, we could show that despite violations of spatial correspondence, the brain specifically integrates certain stimulus combinations which are congruent with respect to our hypothesis of pitch-size synesthesia, thereby impairing performance on an auditory spatial localisation task (Ventriloquist effect). Subsequently, we perturbed this process by functionally disrupting a brain area known for its role in multisensory processes, the right intraparietal sulcus, and observed how the Ventriloquist effect was abolished, thereby increasing behavioural performance. Correlating behavioural, TMS and ERP results, we could retrace the origin of the synesthestic pitch-size mappings to a right intraparietal involvement around 250 ms. The results of this combined psychophysics, TMS and ERP study provide evidence for shifting the current viewpoint on synesthesia more towards synesthesia being at the extremity of a spectrum of normal, adaptive perceptual processes, entailing close interplay between the different sensory systems. Our results support this spectrum view of synesthesia by demonstrating that its neural basis crucially depends on normal multisensory processes. (C) 2011 Elsevier Inc. All rights reserved.

Abstract

The murine homologues of the loci for McLeod syndrome (XK), Dent's disease (CICN5), and synaptophysin (SYP) have been mapped to the proximal region of the mouse X chromosome and positioned with respect to other conserved loci in this region using a total of 948 progeny from two separate Mus musculus x Mus spretus backcrosses. In the mouse, the order of loci and evolutionary breakpoints (EB) has been established as centromere-(DXWas70, DXHXF34h)-EB-Clcn5-(Syp, DXMit55, DXMit26)-Tfe3-Gata1-EB-Xk-Cybb-telomere. In the proximal region of the human X chromosome short arm, the position of evolutionary breakpoints with respect to key loci has been established as DMD-EB-XK-PFC-EB-GATA1-C1CN5-EB-DXS1272E-ALAS2-E B-DXF34-centromere. These data have enabled us to construct a high-resolution genetic map for the approximately 3-cM interval between DXWas70 and Cybb on the mouse X chromosome, which encompasses 10 loci. This detailed map demonstrates the power of high-resolution genetic mapping in the mouse as a means of determining locus order in a small chromosomal region and of providing an accurate framework for the construction of physical maps.

Abstract

Human voices play a fundamental role in social communication, and areas of the adult ‘social brain’ show specialization for processing voices and its emotional content (superior temporal sulcus - STS, inferior prefrontal cortex, premotor cortical regions, amygdala and insula [1-8]. However, it is unclear when this specialization develops. Functional magnetic resonance (fMRI) studies suggest the infant temporal cortex does not differentiate speech from music or backward speech [10, 11], but a prior study with functional near infrared spectroscopy revealed preferential activation for human voices in 7-month-olds, in a more posterior location of the temporal cortex than in adults [12]. Yet, the brain networks involved in processing non-speech human vocalizations in early development are still unknown. For this purpose, in the present fMRI study, 3 to 7 month olds were presented with adult non-speech vocalizations (emotionally neutral, emotionally positive and emotionally negative), and non-vocal environmental sounds. Infants displayed significant activation in the anterior portion of the temporal cortex, similarly to adults [1]. Moreover, sad vocalizations modulated the activity of brain regions known to be involved in processing affective stimuli such as the orbitofrontal cortex [13] and insula [7, 8]. These results suggest remarkably early functional specialization for processing human voice and negative emotions.

Abstract

Many studies have used test batteries for the evaluation of affective behavior in rodents. This has the advantage that treatment effects can be examined on different aspects of the affective domain. However, the behavior in one test may affect the behavior in following test. The present study examined possible order effects in rats that were tested in three different tests: Open Field (OF), Zero Maze (ZM) and Forced Swim Test (FST). The data of the present study indicated that the behavior in ZM was the least affected by the order of testing. In contrast, the behavior in the FST (and to a less extend the OF) was dependent on the order of the test in the test battery. Repeated testing in the same test did not change the behavior in the ZM. However, the behavior in the OF and FST changed with repeated testing. The present study indicates that the performance of rats in a test can be dependent on the order in a test battery. Consequently, these data caution the interpretation of treatment effects in studies in which test batteries are used. (C) 2011 Elsevier B.V. All rights reserved.

Abstract

Just as interlocutors can manipulate physical objects for performing certain types of social action, they can also perform different social actions by manipulating symbolic objects. A kinship system can be thought of as an abstract collection of lexical mappings and associated cultural conventions. It is a sort of cognitive object that can be readily manipulated for special purposes. For example, the relationship between pairs of individuals can be momentarily re-construed in constructing jokes or teases. Murriny Patha speakers associate certain parts of the body with particular classes of kin. When a group of Murriny Patha women witness a cultural outsider performing a forearm-holding gesture that is characteristically associated with brothers-in-law, they re-associate the gesture to the husband–wife relationship, thus setting up an extended teasing episode. Many of these teases call on gestural resources. Although the teasing is at times repetitive, and the episode is only thinly populated with the telltale “off-record” markers that characterize teasing proposals as non-serious, the proposal is sufficiently far-fetched as to ensure that the teases come off as more bonding than biting.

Abstract

Rhythmic properties of spoken language such as metrical stress, that is, the alternation of strong and weak syllables, are important in speech recognition of stress-timed languages such as Dutch and English. Nineteen subjects listened passively to or discriminated actively between sequences of bisyllabic Dutch words, which started with either a weak or a strong syllable. Weak-initial words, which constitute 12% of the Dutch lexicon, evoked more negativity than strong-initial words in the interval between P2 and N400 components of the auditory event-related potential. This negativity was denoted as N325. The N325 was larger during stress discrimination than during passive listening. N325 was also larger when a weak-initial word followed sequence of strong-initial words than when it followed words with the same stress pattern. The latter difference was larger for listeners who performed well on stress discrimination. It was concluded that the N325 is probably a manifestation of the extraction of metrical stress from the acoustic signal and its transformation into task requirements.

Abstract

Language is the result of two concurrent evolutionary processes: Biological and cultural inheritance. An influential evolutionary hypothesis known as the moving target problem implies inherent limitations on the interactions between our two inheritance streams that result from a difference in pace: The speed of cultural evolution is thought to rule out cognitive adaptation to culturally evolving aspects of language. We examine this hypothesis formally by casting it as as a problem of adaptation in time-varying environments. We present a mathematical model of biology-culture co-evolution in finite populations: A generalisation of the Moran process, treating co-evolution as coupled non-independent Markov processes, providing a general formulation of the moving target hypothesis in precise probabilistic terms. Rapidly varying culture decreases the probability of biological adaptation. However, we show that this effect declines with population size and with stronger links between biology and culture: In realistically sized finite populations, stochastic effects can carry cognitive specialisations to fixation in the face of variable culture, especially if the effects of those specialisations are amplified through cultural evolution. These results support the view that language arises from interactions between our two major inheritance streams, rather than from one primary evolutionary process that dominates another. © 2018 The Author(s).

Abstract

PROCEEDINGS OF THE 16TH WORLD CONGRESS OF PSYCHOPHYSIOLOGY of the International Organization of Psychophysiology (IOP) Pisa, Italy September 13-17, 2012