Publications

Displaying 301 - 400 of 831
  • Indefrey, P., Gruber, O., Brown, C. M., Hagoort, P., Posse, S., & Kleinschmidt, A. (1998). Lexicality and not syllable frequency determine lateralized premotor activation during the pronunciation of word-like stimuli: An fMRI study. NeuroImage, 7, S4.
  • Indefrey, P. (2016). On putative shortcomings and dangerous future avenues: response to Strijkers & Costa. Language, Cognition and Neuroscience, 31(4), 517-520. doi:10.1080/23273798.2015.1128554.
  • Isaac, A., Wang, S., Van der Meij, L., Schlobach, S., Zinn, C., & Matthezing, H. (2009). Evaluating thesaurus alignments for semantic interoperability in the library domain. IEEE Intelligent Systems, 24(2), 76-86.

    Abstract

    Thesaurus alignments play an important role in realising efficient access to heterogeneous Cultural Heritage data. Current technology, however, provides only limited value for such access as it fails to bridge the gap between theoretical study and user needs that stem from practical application requirements. In this paper, we explore common real-world problems of a library, and identify solutions that would greatly benefit from a more application embedded study, development, and evaluation of matching technology.
  • Ischebeck, A., Indefrey, P., Usui, N., Nose, I., Hellwig, F. M., & Taira, M. (2004). Reading in a regular orthography: An fMRI study investigating the role of visual familiarity. Journal of Cognitive Neuroscience, 16(5), 727-741. doi:10.1162/089892904970708.

    Abstract

    In order to separate the cognitive processes associated with phonological encoding and the use of a visual word form lexicon in reading, it is desirable to compare the processing of words presented in a visually familiar form with words in a visually unfamiliar form. Japanese Kana orthography offers this possibility. Two phonologically equivalent but visually dissimilar syllabaries allow the writing of, for example, foreign loanwords in two ways, only one of which is visually familiar. Familiarly written words, unfamiliarly written words, and pseudowords were presented in both Kana syllabaries (yielding six conditions in total) to participants during an fMRI measurement with a silent articulation task (Experiment 1) and a phonological lexical decision task (Experiment 2) using an event-related design. Consistent over two experimental tasks, the three different stimulus types (familiar, unfamiliar, and pseudoword) were found to activate selectively different brain regions previously associated with phonological encoding and word retrieval or meaning. Compatible with the predictions of the dual-route model for reading, pseudowords and visually unfamiliar words, which have to be read using phonological assembly, caused an increase in brain activity in left inferior frontal regions (BA 44/47), as compared to visually familiar words. Visually familiar and unfamiliar words were found to activate a range of areas associated with lexico-semantic processing more strongly than pseudowords, such as the left and right temporo-parietal region (BA 39/40), a region in the left middle/inferior temporal gyrus (BA 20/21), and the posterior cingulate (BA 31).
  • Ito, A., Corley, M., Pickering, M. J., Martin, A. E., & Nieuwland, M. S. (2016). Predicting form and meaning: Evidence from brain potentials. Journal of Memory and Language, 86, 157-171. doi:10.1016/j.jml.2015.10.007.

    Abstract

    We used ERPs to investigate the pre-activation of form and meaning in language comprehension. Participants read high-cloze sentence contexts (e.g., “The student is going to the library to borrow a…”), followed by a word that was predictable (book), form-related (hook) or semantically related (page) to the predictable word, or unrelated (sofa). At a 500 ms SOA (Experiment 1), semantically related words, but not form-related words, elicited a reduced N400 compared to unrelated words. At a 700 ms SOA (Experiment 2), semantically related words and form-related words elicited reduced N400 effects, but the effect for form-related words occurred in very high-cloze sentences only. At both SOAs, form-related words elicited an enhanced, post-N400 posterior positivity (Late Positive Component effect). The N400 effects suggest that readers can pre-activate meaning and form information for highly predictable words, but form pre-activation is more limited than meaning pre-activation. The post-N400 LPC effect suggests that participants detected the form similarity between expected and encountered input. Pre-activation of word forms crucially depends upon the time that readers have to make predictions, in line with production-based accounts of linguistic prediction.
  • Jaeger, T. F., & Norcliffe, E. (2009). The cross-linguistic study of sentence production. Language and Linguistics Compass, 3, 866-887. doi:10.1111/j.1749-818x.2009.00147.x.

    Abstract

    The mechanisms underlying language production are often assumed to be universal, and hence not contingent on a speaker’s language. This assumption is problematic for at least two reasons. Given the typological diversity of the world’s languages, only a small subset of languages has actually been studied psycholinguistically. And, in some cases, these investigations have returned results that at least superficially raise doubt about the assumption of universal production mechanisms. The goal of this paper is to illustrate the need for more psycholinguistic work on a typologically more diverse set of languages. We summarize cross-linguistic work on sentence production (specifically: grammatical encoding), focusing on examples where such work has improved our theoretical understanding beyond what studies on English alone could have achieved. But cross-linguistic research has much to offer beyond the testing of existing hypotheses: it can guide the development of theories by revealing the full extent of the human ability to produce language structures. We discuss the potential for interdisciplinary collaborations, and close with a remark on the impact of language endangerment on psycholinguistic research on understudied languages.
  • Janse, E., & Klitsch, J. (2004). Auditieve perceptie bij gezonde sprekers en bij sprekers met verworven taalstoornissen. Afasiologie, 26(1), 2-6.
  • Janse, E. (2006). Auditieve woordherkenning bij afasie: Waarneming van mismatch items. Afasiologie, 28(4), 64-67.
  • Janse, E. (2006). Lexical competition effects in aphasia: Deactivation of lexical candidates in spoken word processing. Brain and Language, 97, 1-11. doi:10.1016/j.bandl.2005.06.011.

    Abstract

    Research has shown that Broca’s and Wernicke’s aphasic patients show different impairments in auditory lexical processing. The results of an experiment with form-overlapping primes showed an inhibitory effect of form-overlap for control adults and a weak inhibition trend for Broca’s aphasic patients, but a facilitatory effect of form-overlap was found for Wernicke’s aphasic participants. This suggests that Wernicke’s aphasic patients are mainly impaired in suppression of once-activated word candidates and selection of one winning candidate, which may be related to their problems in auditory language comprehension.
  • Janse, E. (2009). Neighbourhood density effects in auditory nonword processing in aphasic listeners. Clinical Linguistics and Phonetics, 23(3), 196-207. doi:10.1080/02699200802394989.

    Abstract

    This study investigates neighbourhood density effects on lexical decision performance (both accuracy and response times) of aphasic patients. Given earlier results on lexical activation and deactivation in Broca's and Wernicke's aphasia, the prediction was that smaller neighbourhood density effects would be found for Broca's aphasic patients, compared to age-matched non-brain-damaged control participants, whereas enlarged density effects were expected for Wernicke's aphasic patients. The results showed density effects for all three groups of listeners, and overall differences in performance between groups, but no significant interaction between neighbourhood density and listener group. Several factors are discussed to account for the present results.
  • Janse, E. (2009). Processing of fast speech by elderly listeners. Journal of the Acoustical Society of America, 125(4), 2361-2373. doi:10.1121/1.3082117.

    Abstract

    This study investigates the relative contributions of auditory and cognitive factors to the common finding that an increase in speech rate affects elderly listeners more than young listeners. Since a direct relation between non-auditory factors, such as age-related cognitive slowing, and fast speech performance has been difficult to demonstrate, the present study took an on-line, rather than off-line, approach and focused on processing time. Elderly and young listeners were presented with speech at two rates of time compression and were asked to detect pre-assigned target words as quickly as possible. A number of auditory and cognitive measures were entered in a statistical model as predictors of elderly participants’ fast speech performance: hearing acuity, an information processing rate measure, and two measures of reading speed. The results showed that hearing loss played a primary role in explaining elderly listeners’ increased difficulty with fast speech. However, non-auditory factors such as reading speed and the extent to which participants were affected by
    increased rate of presentation in a visual analog of the listening experiment also predicted fast
    speech performance differences among the elderly participants. These on-line results confirm that slowed information processing is indeed part of elderly listeners’ problem keeping up with fast language
  • Janse, E., & Ernestus, M. (2009). Recognition of reduced speech and use of phonetic context in listeners with age-related hearing impairment [Abstract]. Journal of the Acoustical Society of America, 125(4), 2535.
  • Janse, E. (2004). Word perception in fast speech: Artificially time-compressed vs. naturally produced fast speech. Speech Communication, 42, 155-173. doi:10.1016/j.specom.2003.07.001.

    Abstract

    Natural fast speech differs from normal-rate speech with respect to its temporal pattern. Previous results showed that word intelligibility of heavily artificially time-compressed speech could not be improved by making its temporal pattern more similar to that of natural fast speech. This might have been due to the extrapolation of timing rules for natural fast speech to rates that are much faster than can be attained by human speakers. The present study investigates whether, at a speech rate that human speakers can attain, artificially time-compressed speech is easier to process if its timing pattern is similar to that of naturally produced fast speech. Our first experiment suggests, however, that word processing speed was slowed down, relative to linear compression. In a second experiment, word processing of artificially time-compressed speech was compared with processing of naturally produced fast speech. Even when naturally produced fast speech is perfectly intelligible, its less careful articulation, combined with the changed timing pattern, slows down processing, relative to linearly time-compressed speech. Furthermore, listeners preferred artificially time-compressed speech over naturally produced fast speech. These results suggest that linearly time-compressed speech has both a temporal and a segmental advantage over natural fast speech.
  • Jansma, B. M., & Schiller, N. O. (2004). Monitoring syllable boundaries during speech production. Brain and Language, 90(1-3), 311-317. doi:10.1016/S0093-934X(03)00443-7.

    Abstract

    This study investigated the encoding of syllable boundary information during speech production in Dutch. Based on Levelt's model of phonological encoding, we hypothesized segments and syllable boundaries to be encoded in an incremental way. In a selfmonitoring experiment, decisions about the syllable affiliation (first or second syllable) of a pre-specified consonant, which was the third phoneme in a word, were required (e.g., ka.No canoe vs. kaN.sel pulpit ; capital letters indicate pivotal consonants, dots mark syllable boundaries). First syllable responses were faster than second syllable responses, indicating the incremental nature of segmental encoding and syllabification during speech production planning. The results of the experiment are discussed in the context of Levelt 's model of phonological encoding.
  • Janssen, D. P., Roelofs, A., & Levelt, W. J. M. (2004). Stem complexity and inflectional encoding in language production. Journal of Psycholinguistic Research, 33(5), 365-381. doi:10.1023/B:JOPR.0000039546.60121.a8.

    Abstract

    Three experiments are reported that examined whether stem complexity plays a role in inflecting polymorphemic words in language production. Experiment 1 showed that preparation effects for words with polymorphemic stems are larger when they are produced among words with constant inflectional structures compared to words with variable inflectional structures and simple stems. This replicates earlier findings for words with monomorphemic stems (Janssen et al., 2002). Experiments 2 and 3 showed that when inflectional structure is held constant, the preparation effects are equally large with simple and compound stems, and with compound and complex adjectival stems. These results indicate that inflectional encoding is blind to the complexity of the stem, which suggests that specific inflectional rather than generic morphological frames guide the generation of inflected forms in speaking words.
  • Janssen, R., Nolfi, S., Haselager, W. F. G., & Sprinkhuizen-Kuyper, I. G. (2016). Cyclic Incrementality in Competitive Coevolution: Evolvability through Pseudo-Baldwinian Switching-Genes. Artificial Life, 22(3), 319-352. doi:10.1162/ARTL_a_00208.

    Abstract

    Coevolving systems are notoriously difficult to understand. This is largely due to the Red Queen effect that dictates heterospecific fitness interdependence. In simulation studies of coevolving systems, master tournaments are often used to obtain more informed fitness measures by testing evolved individuals against past and future opponents. However, such tournaments still contain certain ambiguities. We introduce the use of a phenotypic cluster analysis to examine the distribution of opponent categories throughout an evolutionary sequence. This analysis, adopted from widespread usage in the bioinformatics community, can be applied to master tournament data. This allows us to construct behavior-based category trees, obtaining a hierarchical classification of phenotypes that are suspected to interleave during cyclic evolution. We use the cluster data to establish the existence of switching-genes that control opponent specialization, suggesting the retention of dormant genetic adaptations, that is, genetic memory. Our overarching goal is to reiterate how computer simulations may have importance to the broader understanding of evolutionary dynamics in general. We emphasize a further shift from a component-driven to an interaction-driven perspective in understanding coevolving systems. As yet, it is unclear how the sudden development of switching-genes relates to the gradual emergence of genetic adaptability. Likely, context genes gradually provide the appropriate genetic environment wherein the switching-gene effect can be exploited
  • Janzen, G., & Van Turennout, M. (2004). Selective neural representation of objects relevant for navigation. Nature Neuroscience, 7(6), 673-677. doi:10.1038/nn1257.

    Abstract

    As people find their way through their environment, objects at navigationally relevant locations can serve as crucial landmarks. The parahippocampal gyrus has previously been shown to be involved in object and scene recognition. In the present study, we investigated the neural representation of navigationally relevant locations. Healthy human adults viewed a route through a virtual museum with objects placed at intersections (decision points) or at simple turns (non-decision points). Event-related functional magnetic resonance imaging (fMRI) data were acquired during subsequent recognition of the objects in isolation. Neural activity in the parahippocampal gyrus reflected the navigational relevance of an object's location in the museum. Parahippocampal responses were selectively increased for objects that occurred at decision points, independent of attentional demands. This increase occurred for forgotten as well as remembered objects, showing implicit retrieval of navigational information. The automatic storage of relevant object location in the parahippocampal gyrus provides a part of the neural mechanism underlying successful navigation.
  • Janzen, G. (2006). Memory for object location and route direction in virtual large-scale space. Ouarterly Journal of Experimental Psychology, 59(3), 493-508. doi:10.1080/02724980443000746.

    Abstract

    In everyday life people have to deal with tasks such as finding a novel path to a certain goal location, finding one’s way back, finding a short cut, or making a detour. In all of these tasks people acquire route knowledge. For finding the same way back they have to remember locations of objects like buildings and additionally direction changes. In three experiments using recognition tasks as well as conscious and unconscious spatial priming paradigms memory processes underlying wayfinding behaviour were investigated. Participants learned a route through a virtual environment with objects either placed at intersections (i.e., decision points) where another route could be chosen or placed along the route (non-decision points). Analyses indicate first that objects placed at decision points are recognized faster than other objects. Second, they indicate that the direction in which a route is travelled is represented only at locations that are relevant for wayfinding (e.g., decision points). The results point out the efficient way in which memory for object location and memory for route direction interact.
  • Järvikivi, J., Pyykkönen, P., & Niemi, J. (2009). Exploiting degrees of inflectional ambiguity: Stem form and the time course of morphological processing. Journal of Experimental Psychology: Learning, Memory, and Cognition, 35(1), 221-237. doi:10.1037/a0014355.

    Abstract

    The authors compared sublexical and supralexical approaches to morphological processing with unambiguous and ambiguous inflected words and words with ambiguous stems in 3 masked and unmasked priming experiments in Finnish. Experiment 1 showed equal facilitation for all prime types with a short 60-ms stimulus onset asynchrony (SOA) but significant facilitation for unambiguous words only with a long 300-ms SOA. Experiment 2 showed that all potential readings of ambiguous inflections were activated under a short SOA. Whereas the prime-target form overlap did not affect the results under a short SOA, it significantly modulated the results with a long SOA. Experiment 3 confirmed that the results from masked priming were modulated by the morphological structure of the words but not by the prime-target form overlap alone. The results support approaches in which early prelexical morphological processing is driven by morph-based segmentation and form is used to cue selection between 2 candidates only during later processing.

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  • Jaspers, D., & Seuren, P. A. M. (2016). The Square of opposition in catholic hands: A chapter in the history of 20th-century logic. Logique et Analyse, 59(233), 1-35.

    Abstract

    The present study describes how three now almost forgotten mid-20th-century logicians, the American Paul Jacoby and the Frenchmen Augustin Sesmat and Robert Blanché, all three ardent Catholics, tried to restore traditional predicate logic to a position of respectability by expanding the classic Square of Opposition to a hexagon of logical relations, showing the logical and cognitive advantages of such an expansion. The nature of these advantages is discussed in the context of modern research regarding the relations between logic, language, and cognition. It is desirable to call attention to these attempts, as they are, though almost totally forgotten, highly relevant against the backdrop of the clash between modern and traditional logic. It is argued that this clash was and is unnecessary, as both forms of predicate logic are legitimate, each in its own right. The attempts by Jacoby, Sesmat, and Blanché are, moreover, of interest to the history of logic in a cultural context in that, in their own idiosyncratic ways, they fit into the general pattern of the Catholic cultural revival that took place roughly between the years 1840 and 1960. The Catholic Church had put up stiff resistance to modern mathematical logic, considering it dehumanizing and a threat to Catholic doctrine. Both the wider cultural context and the specific implications for logic are described and analyzed, in conjunction with the more general philosophical and doctrinal issues involved.
  • Jesse, A., & Janse, E. (2009). Seeing a speaker's face helps stream segregation for younger and elderly adults [Abstract]. Journal of the Acoustical Society of America, 125(4), 2361.
  • Jiang, T., Zhang, W., Wen, W., Zhu, H., Du, H., Zhu, X., Gao, X., Zhang, H., Dong, Q., & Chen, C. (2016). Reevaluating the two-representation model of numerical magnitude processing. Memory & Cognition, 44, 162-170. doi:10.3758/s13421-015-0542-2.

    Abstract

    One debate in mathematical cognition centers on the single-representation model versus the two-representation model. Using an improved number Stroop paradigm (i.e., systematically manipulating physical size distance), in the present study we tested the predictions of the two models for number magnitude processing. The results supported the single-representation model and, more importantly, explained how a design problem (failure to manipulate physical size distance) and an analytical problem (failure to consider the interaction between congruity and task-irrelevant numerical distance) might have contributed to the evidence used to support the two-representation model. This study, therefore, can help settle the debate between the single-representation and two-representation models. © 2015 The Author(s)
  • Johnson, E. K., & Seidl, A. (2009). At 11 months, prosody still outranks statistics. Developmental Science, 12, 131-141. doi:10.1111/j.1467-7687.2008.00740.x.

    Abstract

    English-learning 7.5-month-olds are heavily biased to perceive stressed syllables as word onsets. By 11 months, however, infants begin segmenting non-initially stressed words from speech.Using the same artificial language methodology as Johnson and Jusczyk (2001), we explored the possibility that the emergence of this ability is linked to a decreased reliance on prosodic cues to word boundaries accompanied by an increased reliance on syllable distribution cues. In a baseline study, where only statistical cues to word boundaries were present, infants exhibited a familiarity preference for statistical words. When conflicting stress cues were added to the speech stream, infants exhibited a familiarity preference for stress as opposed to statistical words. This was interpreted as evidence that 11-month-olds weight stress cues to word boundaries more heavily than statistical cues. Experiment 2 further investigated these results with a language containing convergent cues to word boundaries. The results of Experiment 2 were not conclusive. A third experiment using new stimuli and a different experimental design supported the conclusion that 11-month-olds rely more heavily on prosodic than statistical cues to word boundaries. We conclude that the emergence of the ability to segment non-initially stressed words from speech is not likely to be tied to an increased reliance on syllable distribution cues relative to stress cues, but instead may emerge due to an increased reliance on and integration of a broad array of segmentation cues.
  • Jones, S., Nyberg, L., Sandblom, J., Stigsdotter Neely, A., Ingvar, M., Petersson, K. M., & Bäckman, L. (2006). Cognitive and neural plasticity in aging: General and task-specific limitations. Neuroscience and Biobehavioral Reviews, 30(6), 864-871. doi:10.1016/j.neubiorev.2006.06.012.

    Abstract

    There is evidence for cognitive as well as neural plasticity across the adult life span, although aging is associated with certain constraints on plasticity. In the current paper, we argue that the age-related reduction in cognitive plasticity may be due to (a) deficits in general processing resources, and (b) failure to engage in task-relevant cognitive operations. Memory-training research suggests that age-related processing deficits (e.g., executive functions, speed) hinder older adults from utilizing mnemonic techniques as efficiently as the young, and that this age difference is reflected by diminished frontal activity during mnemonic use. Additional constraints on memory plasticity in old age are related to difficulties that are specific to the task, such as creating visual images, as well as in binding together the information to be remembered. These deficiencies are paralleled by reduced activity in occipito-parietal and medial–temporal regions, respectively. Future attempts to optimize intervention-related gains in old age should consider targeting both general processing and task-specific origins of age-associated reductions in cognitive plasticity.
  • Jordan, F., Gray, R., Greenhill, S., & Mace, R. (2009). Matrilocal residence is ancestral in Austronesian societies. Proceedings of the Royal Society of London Series B-Biological Sciences, 276(1664), 1957-1964. doi:10.1098/rspb.2009.0088.

    Abstract

    The nature of social life in human prehistory is elusive, yet knowing how kinship systems evolve is critical for understanding population history and cultural diversity. Post-marital residence rules specify sex-specific dispersal and kin association, influencing the pattern of genetic markers across populations. Cultural phylogenetics allows us to practise 'virtual archaeology' on these aspects of social life that leave no trace in the archaeological record. Here we show that early Austronesian societies practised matrilocal post-marital residence. Using a Markov-chain Monte Carlo comparative method implemented in a Bayesian phylogenetic framework, we estimated the type of residence at each ancestral node in a sample of Austronesian language trees spanning 135 Pacific societies. Matrilocal residence has been hypothesized for proto-Oceanic society (ca 3500 BP), but we find strong evidence that matrilocality was predominant in earlier Austronesian societies ca 5000-4500 BP, at the root of the language family and its early branches. Our results illuminate the divergent patterns of mtDNA and Y-chromosome markers seen in the Pacific. The analysis of present-day cross-cultural data in this way allows us to directly address cultural evolutionary and life-history processes in prehistory.
  • Jordens, P. (2004). Systematiek en dynamiek bij de verwerving van Finietheid. Toegepaste Taalwetenschap in Artikelen, 71, 9-22.

    Abstract

    In early Dutch learner varieties, there is no evidence of finiteness being a functional category. There is no V2nd: no correlation between inflectional morphology and movement. Initially, learners express the illocutive function of finiteness through the use of illocutive markers, with the non-use of an illocutive marker expressing the default illocutive function of assertion. Illocutive markers are functioning as adjuncts with scope over the predicate. Illocutive markers become re-analysed as functional elements.The driving force is the acquisition of the auxiliary verbs that occur with past participles. It leads to a reanalysis of illocutive markers as two separate elements: an auxiliary verb and a scope adverb. The (modal) auxiliary carries illocutive function. Lexical verb-argument structure (including the external argument) occurs within the domain of the auxiliary verb. The predicate as the focus constituent occurs within the domain of a scope adverb. This reanalysis establishes a position for the external argument within the domain of AUX. The acquisition of AUX causes the acquisition of a (hierarchical) structure with a complement as a constituent which represents an underlying verb-argument structure, a predicate as the domain of elements that are in focus, and an external (specifier) position as a landing site for elements with topic function.
  • Kartushina, N., Hervais-Adelman, A., Frauenfelder, U. H., & Golestani, N. (2016). Mutual influences between native and non-native vowels in production: Evidence from short-term visual articulatory feedback training. Journal of Phonetics, 57, 21-39. doi:10.1016/j.wocn.2016.05.001.

    Abstract

    We studied mutual influences between native and non-native vowel production during learning, i.e., before and after short-term visual articulatory feedback training with non-native sounds. Monolingual French speakers were trained to produce two non-native vowels: the Danish /ɔ/, which is similar to the French /o/, and the Russian /ɨ/, which is dissimilar from French vowels. We examined relationships between the production of French and non-native vowels before training, and the effects of training with non-native vowels on the production of French ones. We assessed for each participant the acoustic position and compactness of the trained vowels, and of the French /o/, /ø/, /y/ and /i/ vowels, which are acoustically closest to the trained vowels. Before training, the compactness of the French vowels was positively related to the accuracy and compactness in the production of non-native vowels. After training, French speakers’ accuracy and stability in the production of the two trained vowels improved on average by 19% and 37.5%, respectively. Interestingly, the production of native vowels was also affected by this learning process, with a drift towards non-native vowels. The amount of phonetic drift appears to depend on the degree of similarity between the native and non-native sounds.
  • Kavaklioglu, T., Ajmal, M., Hameed, A., & Francks, C. (2016). Whole exome sequencing for handedness in a large and highly consanguineous family. Neuropsychologia, 93, part B, 342-349. doi:10.1016/j.neuropsychologia.2015.11.010.

    Abstract

    Pinpointing genes involved in non-right-handedness has the potential to clarify developmental contributions to human brain lateralization. Major-gene models have been considered for human handedness which allow for phenocopy and reduced penetrance, i.e. an imperfect correspondence between genotype and phenotype. However, a recent genome-wide association scan did not detect any common polymorphisms with substantial genetic effects. Previous linkage studies in families have also not yielded significant findings. Genetic heterogeneity and/or polygenicity are therefore indicated, but it remains possible that relatively rare, or even unique, major-genetic effects may be detectable in certain extended families with many non-right-handed members. Here we applied whole exome sequencing to 17 members from a single, large consanguineous family from Pakistan. Multipoint linkage analysis across all autosomes did not yield clear candidate genomic regions for involvement in the trait and single-point analysis of exomic variation did not yield clear candidate mutations/genes. Any genetic contribution to handedness in this unusual family is therefore likely to have a complex etiology, as at the population level.
  • Kempen, G. (2009). Clausal coordination and coordinative ellipsis in a model of the speaker. Linguistics, 47(3), 653-696. doi:10.1515/LING.2009.022.

    Abstract

    This article presents a psycholinguistically inspired approach to the syntax of clause-level coordination and coordinate ellipsis. It departs from the assumption that coordinations are structurally similar to so-called appropriateness repairs — an important type of self-repairs in spontaneous speech. Coordinate structures and appropriateness repairs can both be viewed as “update” constructions. Updating is defined as a special sentence production mode that efficiently revises or augments existing sentential structure in response to modifications in the speaker's communicative intention. This perspective is shown to offer an empirically satisfactory and theoretically parsimonious account of two prominent types of coordinate ellipsis, in particular “forward conjunction reduction” (FCR) and “gapping” (including “long-distance gapping” and “subgapping”). They are analyzed as different manifestations of “incremental updating” — efficient updating of only part of the existing sentential structure. Based on empirical data from Dutch and German, novel treatments are proposed for both types of clausal coordinate ellipsis. The coordination-as-updating perspective appears to explain some general properties of coordinate structure: the existence of the well-known “coordinate structure constraint”, and the attractiveness of three-dimensional representations of coordination. Moreover, two other forms of coordinate ellipsis — SGF (“subject gap in finite clauses with fronted verb”), and “backward conjunction reduction” (BCR) (also known as “right node raising” or RNR) — are shown to be incompatible with the notion of incremental updating. Alternative theoretical interpretations of these phenomena are proposed. The four types of clausal coordinate ellipsis — SGF, gapping, FCR and BCR — are argued to originate in four different stages of sentence production: Intending (i.e., preparing the communicative intention), conceptualization, grammatical encoding, and phonological encoding, respectively.
  • Kempen, G. (1998). Comparing and explaining the trajectories of first and second language acquisition: In search of the right mix of psychological and linguistic factors [Commentory]. Bilingualism: Language and Cognition, 1, 29-30. doi:10.1017/S1366728998000066.

    Abstract

    When you compare the behavior of two different age groups which are trying to master the same sensori-motor or cognitive skill, you are likely to discover varying learning routes: different stages, different intervals between stages, or even different orderings of stages. Such heterogeneous learning trajectories may be caused by at least six different types of factors: (1) Initial state: the kinds and levels of skills the learners have available at the onset of the learning episode. (2) Learning mechanisms: rule-based, inductive, connectionist, parameter setting, and so on. (3) Input and feedback characteristics: learning stimuli, information about success and failure. (4) Information processing mechanisms: capacity limitations, attentional biases, response preferences. (5) Energetic variables: motivation, emotional reactions. (6) Final state: the fine-structure of kinds and levels of subskills at the end of the learning episode. This applies to language acquisition as well. First and second language learners probably differ on all six factors. Nevertheless, the debate between advocates and opponents of the Fundamental Difference Hypothesis concerning L1 and L2 acquisition have looked almost exclusively at the first two factors. Those who believe that L1 learners have access to Universal Grammar whereas L2 learners rely on language processing strategies, postulate different learning mechanisms (UG parameter setting in L1, more general inductive strategies in L2 learning). Pienemann opposes this view and, based on his Processability Theory, argues that L1 and L2 learners start out from different initial states: they come to the grammar learning task with different structural hypotheses (SOV versus SVO as basic word order of German).
  • Kempen, G. (1973). [Review of the book Psycholinguïstiek by B. Tervoort et al.]. Nederlands Tijdschrift voor de Psychologie, 28, 172-174.
  • Kempen, G. (1985). Psychologie 2000. Toegepaste psychologie in de informatiemaatschappij. Computers in de psychologie, 13-21.
  • Kempen, G., & Harbusch, K. (2016). Verb-second word order after German weil ‘because’: psycholinguistic theory from corpus-linguistic data. Glossa: a journal of general linguistics, 1(1): 3. doi:10.5334/gjgl.46.

    Abstract

    In present-day spoken German, subordinate clauses introduced by the connector weil ‘because’ occur with two orders of subject, finite verb, and object(s). In addition to weil clauses with verb-final word order (“VF”; standard in subordinate clauses) one often hears weil clauses with SVO, the standard order of main clauses (“verb-second”, V2). The “weil-V2” phenomenon is restricted to sentences where the weil clause follows the main clause, and is virtually absent from formal (written, edited) German, occurring only in extemporaneous speech. Extant accounts of weil-V2 focus on the interpretation of weil-V2 clauses by the hearer, in particular on the type of discourse relation licensed by weil-V2 vs. weil-VF: causal/propositional or inferential/epistemic. Focusing instead on the production of weil clauses by the speaker, we examine a collection of about 1,000 sentences featuring a causal connector (weil, da or denn) after the main clause, all extracted from a corpus of spoken German dialogues and annotated with tags denoting major prosodic and syntactic boundaries, and various types of disfluencies (pauses, hesitations). Based on the observed frequency patterns and on known linguistic properties of the connectors, we propose that weil-V2 is caused by miscoordination between the mechanisms for lexical retrieval and grammatical encoding: Due to its high frequency, the lexical item weil is often selected prematurely, while the grammatical encoder is still working on the syntactic shape of the weil clause. Weil-V2 arises when pragmatic and processing factors drive the encoder to discontinue the current sentence, and to plan the clause following weil in the form of the main clause of an independent, new sentence. Thus, the speaker continues with a V2 clause, seemingly in violation of the VF constraint imposed by the preceding weil. We also explore implications of the model regarding the interpretation of sentences containing causal connectors.
  • Kemps, R. J. J. K., Ernestus, M., Schreuder, R., & Baayen, R. H. (2004). Processing reduced word forms: The suffix restoration effect. Brain and Language, 90(1-3), 117-127. doi:10.1016/S0093-934X(03)00425-5.

    Abstract

    Listeners cannot recognize highly reduced word forms in isolation, but they can do so when these forms are presented in context (Ernestus, Baayen, & Schreuder, 2002). This suggests that not all possible surface forms of words have equal status in the mental lexicon. The present study shows that the reduced forms are linked to the canonical representations in the mental lexicon, and that these latter representations induce reconstruction processes. Listeners restore suffixes that are partly or completely missing in reduced word forms. A series of phoneme-monitoring experiments reveals the nature of this restoration: the basis for suffix restoration is mainly phonological in nature, but orthography has an influence as well.
  • Kemps-Snijders, M., Windhouwer, M., Wittenburg, P., & Wright, S. E. (2009). ISOcat: Remodeling metadata for language resources. International Journal of Metadata, Semantics and Ontologies (IJMSO), 4(4), 261-276. doi:10.1504/IJMSO.2009.029230.

    Abstract

    The Max Planck Institute for Psycholinguistics in Nijmegen, The Netherlands, is creating a state-of-the-art web environment for the ISO TC 37 (terminology and other language and content resources) metadata registry. This Data Category Registry (DCR) is called ISOcat and encompasses data categories for a broad range of language resources. Under the governance of the DCR Board, ISOcat provides an open work space for creating data category specifications, defining Data Category Selections (DCSs) (domain-specific groups of data categories), and standardising selected data categories and DCSs. Designers visualise future interactivity among the DCR, reference registries and ontological knowledge spaces
  • Kendrick, K. H., & Drew, P. (2016). Recruitment: Offers, requests, and the organization of assistance in interaction. Research on Language and Social Interaction, 49(1), 1-19. doi:10.1080/08351813.2016.1126436.

    Abstract

    In this article, we examine methods that participants use to resolve troubles in the realization of practical courses of action. The concept of recruitment is developed to encompass the linguistic and embodied ways in which assistance may be sought – requested or solicited – or in which we come to perceive another’s need and offer or volunteer assistance. We argue that these methods are organized as a continuum, from explicit requests, to practices that elicit offers, to anticipations of need. We further identify a class of subsidiary actions that can precede recruitment and that publicly expose troubles and thereby create opportunities for others to assist. Data in American and British English.
  • Kendrick, K. H., & Drew, P. (2016). The boundary of recruitment: A response. Research on Language and Social Interaction, 49, 32-33. doi:10.1080/08351813.2016.1126442.

    Abstract

    In their commentaries, both Heritage (2016/this issue) and Zinken and Rossi (2016/this issue) provide some context for our concept of and approach to recruitment in terms of previous research into requesting and offering. In doing so, they usefully consider what might be the boundaries of recruitmentwhat might be included and what might not be included or treated as recruitment. We respond here to their suggestions concerning these boundaries.
  • Kent, A., & Kendrick, K. H. (2016). Imperative directives: Orientations to accountability. Research on Language and Social Interaction, 49(3), 272-288. doi:10.1080/08351813.2016.1201737.

    Abstract

    Our analysis proceeds from the question that if grammar alone is insuffi- cient to identify the action of an imperative (e.g., offering, directing, warn- ing, begging, etc.), how can interlocutors come to recognize the specific action being performed by a given imperative? We argue that imperative directives that occur after the directed action could have first been rele- vantly performed explicitly to direct the actions of the recipient and tacitly treat the absence of the action as a failure for which the recipient is accountable. The tacit nature of the accountability orientation enables both parties to focus on restoring progressivity to the directed course of action rather than topicalizing a transgression. Data are from everyday interactions in British and American English.
  • Kidd, E., & Holler, J. (2009). Children’s use of gesture to resolve lexical ambiguity. Developmental Science, 12, 903-913.
  • Kidd, E. (2009). [Review of the book Constructions at work: The nature of generalization in language by Adele E. Goldberg]. Cognitive Linguistics, 20(2), 425-434. doi:10.1515/COGL.2009.020.
  • Kidd, E. (2009). [Review of the book Developmental psycholinguistics; On-line methods in children's language processing ed. by Irina A. Sekerina, Eva M. Hernandez and Harald Clahsen]. Journal of Child Language, 36(2), 471-475. doi:10.1017/S030500090800901X.
  • Kidd, E. (2006). [Review of the book Syntactic carpentry: An emergentist approach to syntax by William O'Grady]. Journal of Child Language, 33(4), 905-910. doi:10.1017/S030500090622782X.
  • Kidd, E., & Arciuli, J. (2016). Individual Differences in Statistical Learning Predict Children's Comprehension of Syntax. Child Development, 87(1), 184-193. doi:10.1111/cdev.12461.

    Abstract

    Variability in children's language acquisition is likely due to a number of cognitive and social variables. The current study investigated whether individual differences in statistical learning (SL), which has been implicated in language acquisition, independently predicted 6- to 8-year-old's comprehension of syntax. Sixty-eight (N = 68) English-speaking children completed a test of comprehension of four syntactic structures, a test of SL utilizing nonlinguistic visual stimuli, and several additional control measures. The results revealed that SL independently predicted comprehension of two syntactic structures that show considerable variability in this age range: passives and object relative clauses. These data suggest that individual differences in children's capacity for SL are associated with the acquisition of the syntax of natural languages.
  • Kidd, E., Kemp, N., Kashima, E. S., & Quinn, S. (2016). Language, culture, and group membership: An investigation into the social effects of colloquial Australian English. Journal of Cross-Cultural Psychology, 47(5), 713-733. doi:10.1177/0022022116638175.

    Abstract

    Languages are strong markers of social identity. Multiple features of language and speech, from accent to lexis to grammatical constructions, mark speakers as members of specific cultural groups. In the current article, we present two confederate-scripted studies that investigated the social effects of the Australian hypocoristic use (e.g., uggie, uni, derro)—a lexical category emblematic of Australian culture. Participants took turns with a confederate directing each other through locations on a map. In their directions, the confederate used either hypocoristic (e.g., uni) or standard forms (e.g., university). The confederate’s cultural group membership and member prototypicality were manipulated by ethnic background and accent: In a highly prototypical in-group condition, the confederate had an Anglo-Celtic background and Australian English (AusE) accent; in a low prototypical in-group condition, the confederate had an Asian background and AusE accent; and in the out-group condition, the confederate had an Asian background and non-AusE accent. Hypocoristic use resulted in significantly higher participant-rated perceived common ground with the confederate when the confederate was an in-group but not an out-group member, which in some instances was moderated by in-group identification. The results suggest that like accents, culturally significant lexical categories function as markers of in-group identity, which influence perceived social closeness during interaction.
  • Kidd, E. (2004). Grammars, parsers, and language acquisition. Journal of Child Language, 31(2), 480-483. doi:10.1017/S0305000904006117.

    Abstract

    Drozd's critique of Crain & Thornton's (C&T) (1998) book Investigations in Universal Grammar (IUG) raises many issues concerning theory and experimental design within generative approaches to language acquisition. I focus here on one of the strongest theoretical claims of the Modularity Matching Model (MMM): continuity of processing. For reasons different to Drozd, I argue that the assumption is tenuous. Furthermore, I argue that the focus of the MMM and the methodological prescriptions contained in IUG are too narrow to capture language acquisition.
  • Kidd, E., Lieven, E., & Tomasello, M. (2006). Examining the role of lexical frequency in children's acquisition of sentential complements. Cognitive Development, 21(2), 93-107. doi:10.1016/j.cogdev.2006.01.006.

    Abstract

    We present empirical data showing that the relative frequency with which a verb normally appears in a syntactic construction predicts young children's ability to remember and repeat sentences instantiating that construction. Children aged 2;10–5;8 years were asked to repeat grammatical and ungrammatical sentential complement sentences (e.g., ‘I think + S’). The sentences contained complement-taking verbs (CTVs) used with differing frequencies in children's natural speech. All children repeated sentences containing high frequency CTVs (e.g., think) more accurately than those containing low frequency CTVs (e.g., hear), and made more sophisticated corrections to ungrammatical sentences containing high frequency CTVs. The data suggest that, like adults, children are sensitive to lexico-constructional collocations. The implications for language acquisition are discussed.
  • Kircher, T. T. J., Brammer, M. J., Levelt, W. J. M., Bartels, M., & McGuire, P. K. (2004). Pausing for thought: Engagement of left temporal cortex during pauses in speech. NeuroImage, 21(1), 84-90. doi:10.1016/j.neuroimage.2003.09.041.

    Abstract

    Pauses during continuous speech, particularly those that occur within clauses, are thought to reflect the planning of forthcoming verbal output. We used functional Magnetic Resonance Imaging (fMRI) to examine their neural correlates. Six volunteers were scanned while describing seven Rorschach inkblots, producing 3 min of speech per inkblot. In an event-related design, the level of blood oxygenation level dependent (BOLD) contrast during brief speech pauses (mean duration 1.3 s, SD 0.3 s) during overt speech was contrasted with that during intervening periods of articulation. We then examined activity associated with pauses that occurred within clauses and pauses that occurred between grammatical junctions. Relative to articulation during speech, pauses were associated with activation in the banks of the left superior temporal sulcus (BA 39/22), at the temporoparietal junction. Continuous speech was associated with greater activation bilaterally in the inferior frontal (BA 44/45), middle frontal (BA 8) and anterior cingulate (BA 24) gyri, the middle temporal sulcus (BA 21/22), the occipital cortex and the cerebellum. Left temporal activation was evident during pauses that occurred within clauses but not during pauses at grammatical junctions. In summary, articulation during continuous speech involved frontal, temporal and cerebellar areas, while pausing was associated with activity in the left temporal cortex, especially when this occurred within a clause. The latter finding is consistent with evidence that within-clause pauses are a correlate of speech planning and in particular lexical retrieval.
  • Klassmann, A., Offenga, F., Broeder, D., & Skiba, R. (2006). IMDI metadata field usage at MPI. Language Archive Newsletter, no. 8, 6-8.
  • Klein, W. (Ed.). (2004). Philologie auf neuen Wegen [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, 136.
  • Klein, W. (Ed.). (2004). Universitas [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik (LiLi), 134.
  • Klein, W. (2004). Vom Wörterbuch zum digitalen lexikalischen System. Zeitschrift für Literaturwissenschaft und Linguistik, 136, 10-55.
  • Klein, K. M., Pendziwiat, M., Cohen, R., Appenzeller, S., De Kovel, C. G. F., Rosenow, F., Koeleman, B. P., Kuhlenbaumer, G., Sheintuch, L., Veksler, R., Friedman, A., Afawi, Z., & Helbig, I. (2016). Autosomal dominant epilepsy with auditory features: a new LGI1 family including a phenocopy with cortical dysplasia. Journal of Neurology, 263(1), 11-6. doi:10.1007/s00415-015-7921-2.
  • Klein, W. (1973). Eine Analyse der Kerne in Schillers "Räuber". Cahiers de linguistique théorique et appliquée, 10, 195-200.
  • Klein, W. (1985). Einleitung. Zeitschrift für Literaturwissenschaft und Linguistik; Metzler, Stuttgart, 15(59), 7-8.
  • Klein, W. (2004). Auf der Suche nach den Prinzipien, oder: Warum die Geisteswissenschaften auf dem Rückzug sind. Zeitschrift für Literaturwissenschaft und Linguistik, 134, 19-44.
  • Klein, W., & Von Stutterheim, C. (2006). How to solve a complex verbal task: Text structure, referential movement and the quaestio. Aquisição de Linguas Estrangeiras, 30/31, 29-67.
  • Klein, W. (2004). Im Lauf der Jahre. Linguistische Berichte, 200, 397-407.
  • Klein, W. (1985). Gesprochene Sprache - geschriebene Sprache. Zeitschrift für Literaturwissenschaft und Linguistik, 59, 9-35.
  • Klein, W. (Ed.). (1998). Kaleidoskop [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (112).
  • Klein, W. (1998). The contribution of second language acquisition research. Language Learning, 48, 527-550. doi:10.1111/0023-8333.00057.

    Abstract

    During the last 25 years, second language acquisition (SLA) research hasmade considerable progress, but is still far from proving a solid basis for foreign language teaching, or from a general theory of SLA. In addition, its status within the linguistic disciplines is still very low. I argue this has not much to do with low empirical or theoretical standards in the field—in this regard, SLA research is fully competitive—but with a particular perspective on the acquisition process: SLA researches learners' utterances as deviations from a certain target, instead of genuine manifestations of underlying language capacity; it analyses them in terms of what they are not rather than what they are. For some purposes such a "target deviation perspective" makes sense, but it will not help SLA researchers to substantially and independently contribute to a deeper understanding of the structure and function of the human language faculty. Therefore, these findings will remain of limited interest to other scientists until SLA researchers consider learner varieties a normal, in fact typical, manifestation of this unique human capacity.
  • Klein, W. (Ed.). (1985). Schriftlichkeit [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, (59).
  • Klein, W. (2004). Was die Geisteswissenschaften leider noch von den Naturwissenschaften unterscheidet. Gegenworte, 13, 79-84.
  • Klein, W., & Dimroth, C. (Eds.). (2009). Worauf kann sich der Sprachunterricht stützen? [Special Issue]. Zeitschrift für Literaturwissenschaft und Linguistik, 153.
  • Klein, W. (1998). Von der einfältigen Wißbegierde. Zeitschrift für Literaturwissenschaft und Linguistik, 112, 6-13.
  • Koch, X., & Janse, E. (2016). Speech rate effects on the processing of conversational speech across the adult life span. The Journal of the Acoustical Society of America, 139(4), 1618-1636. doi:10.1121/1.4944032.

    Abstract

    This study investigates the effect of speech rate on spoken word recognition across the adult life span. Contrary to previous studies, conversational materials with a natural variation in speech rate were used rather than lab-recorded stimuli that are subsequently artificially time-compressed. It was investigated whether older adults' speech recognition is more adversely affected by increased speech rate compared to younger and middle-aged adults, and which individual listener characteristics (e.g., hearing, fluid cognitive processing ability) predict the size of the speech rate effect on recognition performance. In an eye-tracking experiment, participants indicated with a mouse-click which visually presented words they recognized in a conversational fragment. Click response times, gaze, and pupil size data were analyzed. As expected, click response times and gaze behavior were affected by speech rate, indicating that word recognition is more difficult if speech rate is faster. Contrary to earlier findings, increased speech rate affected the age groups to the same extent. Fluid cognitive processing ability predicted general recognition performance, but did not modulate the speech rate effect. These findings emphasize that earlier results of age by speech rate interactions mainly obtained with artificially speeded materials may not generalize to speech rate variation as encountered in conversational speech.
  • Koch, X., Dingemanse, G., Goedegebure, A., & Janse, E. (2016). Type of speech material affects Acceptable Noise Level outcome. Frontiers in Psychology, 7: 186. doi:10.3389/fpsyg.2016.00186.

    Abstract

    The Acceptable Noise Level (ANL) test, in which individuals indicate what level of noise they are willing to put up with while following speech, has been used to guide hearing aid fitting decisions and has been found to relate to prospective hearing aid use. Unlike objective measures of speech perception ability, ANL outcome is not related to individual hearing loss or age, but rather reflects an individual's inherent acceptance of competing noise while listening to speech. As such, the measure may predict aspects of hearing aid success. Crucially, however, recent studies have questioned its repeatability (test-retest reliability). The first question for this study was whether the inconsistent results regarding the repeatability of the ANL test may be due to differences in speech material types used in previous studies. Second, it is unclear whether meaningfulness and semantic coherence of the speech modify ANL outcome. To investigate these questions, we compared ANLs obtained with three types of materials: the International Speech Test Signal (ISTS), which is non-meaningful and semantically non-coherent by definition, passages consisting of concatenated meaningful standard audiology sentences, and longer fragments taken from conversational speech. We included conversational speech as this type of speech material is most representative of everyday listening. Additionally, we investigated whether ANL outcomes, obtained with these three different speech materials, were associated with self-reported limitations due to hearing problems and listening effort in everyday life, as assessed by a questionnaire. ANL data were collected for 57 relatively good-hearing adult participants with an age range representative for hearing aid users. Results showed that meaningfulness, but not semantic coherence of the speech material affected ANL. Less noise was accepted for the non-meaningful ISTS signal than for the meaningful speech materials. ANL repeatability was comparable across the speech materials. Furthermore, ANL was found to be associated with the outcome of a hearing-related questionnaire. This suggests that ANL may predict activity limitations for listening to speech-in-noise in everyday situations. In conclusion, more natural speech materials can be used in a clinical setting as their repeatability is not reduced compared to more standard materials.
  • Konopka, A. E., & Bock, K. (2009). Lexical or syntactic control of sentence formulation? Structural generalizations from idiom production. Cognitive Psychology, 58, 68-101. doi:10.1016/j.cogpsych.2008.05.002.

    Abstract

    To compare abstract structural and lexicalist accounts of syntactic processes in sentence formulation, we examined the effectiveness of nonidiomatic and idiomatic phrasal verbs in inducing structural generalizations. Three experiments made use of a syntactic priming paradigm in which participants recalled sentences they had read in rapid serial visual presentation. Prime and target sentences contained phrasal verbs with particles directly following the verb (pull off a sweatshirt) or following the direct object (pull a sweatshirt off). Idiomatic primes used verbs whose figurative meaning cannot be straightforwardly derived from the literal meaning of the main verb (e.g., pull off a robbery) and are commonly treated as stored lexical units. Particle placement in sentences was primed by both nonidiomatic and idiomatic verbs. Experiment 1 showed that the syntax of idiomatic and nonidiomatic phrasal verbs is amenable to priming, and Experiments 2 and 3 compared the priming patterns created by idiomatic and nonidiomatic primes. Despite differences in idiomaticity and structural flexibility, both types of phrasal verbs induced structural generalizations and differed little in their ability to do so. The findings are interpreted in terms of the role of abstract structural processes in language production.
  • Konopka, A. E., & Benjamin, A. (2009). Schematic knowledge changes what judgments of learning predict in a source memory task. Memory & Cognition, 37(1), 42-51. doi:10.3758/MC.37.1.42.

    Abstract

    Source monitoring can be influenced by information that is external to the study context, such as beliefs and general knowledge (Johnson, Hashtroudi, & Lindsay, 1993). We investigated the extent to which metamnemonic judgments predict memory for items and sources when schematic information about the sources is or is not provided at encoding. Participants made judgments of learning (JOLs) to statements presented by two speakers and were informed of the occupation of each speaker either before or after the encoding session. Replicating earlier work, prior knowledge decreased participants' tendency to erroneously attribute statements to schematically consistent but episodically incorrect speakers. The origin of this effect can be understood by examining the relationship between JOLs and performance: JOLs were equally predictive of item and source memory in the absence of prior knowledge, but were exclusively predictive of source memory when participants knew of the relationship between speakers and statements during study. Background knowledge determines the information that people solicit in service of metamnemonic judgments, suggesting that these judgments reflect control processes during encoding that reduce schematic errors.
  • Kooijman, V., Hagoort, P., & Cutler, A. (2009). Prosodic structure in early word segmentation: ERP evidence from Dutch ten-month-olds. Infancy, 14, 591 -612. doi:10.1080/15250000903263957.

    Abstract

    Recognizing word boundaries in continuous speech requires detailed knowledge of the native language. In the first year of life, infants acquire considerable word segmentation abilities. Infants at this early stage in word segmentation rely to a large extent on the metrical pattern of their native language, at least in stress-based languages. In Dutch and English (both languages with a preferred trochaic stress pattern), segmentation of strong-weak words develops rapidly between 7 and 10 months of age. Nevertheless, trochaic languages contain not only strong-weak words but also words with a weak-strong stress pattern. In this article, we present electrophysiological evidence of the beginnings of weak-strong word segmentation in Dutch 10-month-olds. At this age, the ability to combine different cues for efficient word segmentation does not yet seem to be completely developed. We provide evidence that Dutch infants still largely rely on strong syllables, even for the segmentation of weak-strong words.
  • Koornneef, A. W., & Van Berkum, J. J. A. (2006). On the use of verb-based implicit causality in sentence comprehension: Evidence from self-paced reading and eye tracking. Journal of Memory and Language, 54(4), 445-465. doi:10.1016/j.jml.2005.12.003.

    Abstract

    In two experiments, we examined the recent claim (Stewart, Pickering, & Sanford, 2000) that verb-based implicit causality information is used during sentence–final clausal integration only. We did so by looking for mid-sentence reading delays caused by pronouns that are inconsistent with the bias of a preceding implicit causality verb (e.g., “David praised Linda because he…”). In a self-paced reading task, such pronouns immediately slowed down reading, at the two words immediately following the pronoun. In eye tracking, bias-inconsistent pronouns also immediately perturbed the reading process, as indexed by significant delays in various first pass measures at and shortly after the critical pronoun. Hence, readers can recruit verb-based implicit causality information in the service of comprehension rapidly enough to impact on the interpretation of a pronoun early in the subordinate clause. We take our results to suggest that implicit causality is used proactively, allowing readers to focus on, and perhaps even predict, who or what will be talked about next.
  • Kopecka, A. (2009). L'expression du déplacement en Français: L'interaction des facteurs sémantiques, aspectuels et pragmatiques dans la construction du sens spatial. Langages, 173, 54-75.

    Abstract

    The paper investigates the use of manner verbs (e.g. marcher 'to walk', courir 'to run') with so-called locative prepositions (e.g. dans 'in', sous 'under') in the descriptions of motion in French, as in Il a couru dans le bureau 'He ran in (to) the office', to explore the type of events such constructions express and the factors that influence their interpretation. Based on an extensive corpus survey, the study shows that, contrary to the general claim according to which such constructions express typically motion in some location, they are also frequently used to express change of location. The study discusses the interplay of various factors that contribute to the interpretation of these constructions, including semantic, aspectual and pragmatic factors.
  • Korvorst, M., Roelofs, A., & Levelt, W. J. M. (2006). Incrementality in naming and reading complex numerals: Evidence from eyetracking. Quarterly Journal of Experimental Psychology, 59(2), 296-311. doi:10.1080/17470210500151691.

    Abstract

    Individuals speak incrementally when they interleave planning and articulation. Eyetracking, along with the measurement of speech onset latencies, can be used to gain more insight into the degree of incrementality adopted by speakers. In the current article, two eyetracking experiments are reported in which pairs of complex numerals were named (arabic format, Experiment 1) or read aloud (alphabetic format, Experiment 2) as house numbers and as clock times. We examined whether the degree of incrementality is differentially influenced by the production task (naming vs. reading) and mode (house numbers vs. clock time expressions), by comparing gaze durations and speech onset latencies. In both tasks and modes, dissociations were obtained between speech onset latencies (reflecting articulation) and gaze durations (reflecting planning), indicating incrementality. Furthermore, whereas none of the factors that determined gaze durations were reflected in the reading and naming latencies for the house numbers, the dissociation between gaze durations and response latencies for the clock times concerned mainly numeral length in both tasks. These results suggest that the degree of incrementality is influenced by the type of utterance (house number vs. clock time) rather than by task (reading vs. naming). The results highlight the importance of the utterance structure in determining the degree of incrementality.
  • Kos, A., Wanke, K., Gioio, A., Martens, G. J., Kaplan, B. B., & Aschrafi, A. (2016). Monitoring mRNA Translation in Neuronal Processes Using Fluorescent Non-Canonical Amino Acid Tagging. Journal of Histochemistry and Cytochemistry, 64(5), 323-333. doi:10.1369/0022155416641604.

    Abstract

    A steady accumulation of experimental data argues that protein synthesis in neurons is not merely restricted to the somatic compartment, but also occurs in several discrete cellular micro-domains. Local protein synthesis is critical for the establishment of synaptic plasticity in mature dendrites and in directing the growth cones of immature axons, and has been associated with cognitive impairment in mice and humans. Although in recent years a number of important mechanisms governing this process have been described, it remains technically challenging to precisely monitor local protein synthesis in individual neuronal cell parts independent from the soma. This report presents the utility of employing microfluidic chambers for the isolation and treatment of single neuronal cellular compartments. Furthermore, it is demonstrated that a protein synthesis assay, based on fluorescent non-canonical amino acid tagging (FUNCAT), can be combined with this cell culture system to label nascent proteins within a discrete structural and functional domain of the neuron. Together, these techniques could be employed for the detection of protein synthesis within developing and mature neurites, offering an effective approach to elucidate novel mechanisms controlling synaptic maintenance and plasticity.
  • Kösem, A., Basirat, A., Azizi, L., & van Wassenhove, V. (2016). High frequency neural activity predicts word parsing in ambiguous speech streams. Journal of Neurophysiology, 116(6), 2497-2512. doi:10.1152/jn.00074.2016.

    Abstract

    During speech listening, the brain parses a continuous acoustic stream of information into computational units (e.g. syllables or words) necessary for speech comprehension. Recent neuroscientific hypotheses propose that neural oscillations contribute to speech parsing, but whether they do so on the basis of acoustic cues (bottom-up acoustic parsing) or as a function of available linguistic representations (top-down linguistic parsing) is unknown. In this magnetoencephalography study, we contrasted acoustic and linguistic parsing using bistable speech sequences. While listening to the speech sequences, participants were asked to maintain one of the two possible speech percepts through volitional control. We predicted that the tracking of speech dynamics by neural oscillations would not only follow the acoustic properties but also shift in time according to the participant’s conscious speech percept. Our results show that the latency of high-frequency activity (specifically, beta and gamma bands) varied as a function of the perceptual report. In contrast, the phase of low-frequency oscillations was not strongly affected by top-down control. While changes in low-frequency neural oscillations were compatible with the encoding of pre-lexical segmentation cues, high-frequency activity specifically informed on an individual’s conscious speech percept.

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  • Köster, O., Hess, M. M., Schiller, N. O., & Künzel, H. J. (1998). The correlation between auditory speech sensitivity and speaker recognition ability. Forensic Linguistics: The international Journal of Speech, Language and the Law, 5, 22-32.

    Abstract

    In various applications of forensic phonetics the question arises as to how far aural-perceptual speaker recognition performance is reliable. Therefore, it is necessary to examine the relationship between speaker recognition results and human perception/production abilities like musicality or speech sensitivity. In this study, performance in a speaker recognition experiment and a speech sensitivity test are correlated. The results show a moderately significant positive correlation between the two tasks. Generally, performance in the speaker recognition task was better than in the speech sensitivity test. Professionals in speech and singing yielded a more homogeneous correlation than non-experts. Training in speech as well as choir-singing seems to have a positive effect on performance in speaker recognition. It may be concluded, firstly, that in cases where the reliability of voice line-up results or the credibility of a testimony have to be considered, the speech sensitivity test could be a useful indicator. Secondly, the speech sensitivity test might be integrated into the canon of possible procedures for the accreditation of forensic phoneticians. Both tests may also be used in combination.
  • Koten Jr., J. W., Wood, G., Hagoort, P., Goebel, R., Propping, P., Willmes, K., & Boomsma, D. I. (2009). Genetic contribution to variation in cognitive function: An fMRI study in twins. Science, 323(5922), 1737-1740. doi:10.1126/science.1167371.

    Abstract

    Little is known about the genetic contribution to individual differences in neural networks subserving cognition function. In this functional magnetic resonance imaging (fMRI) twin study, we found a significant genetic influence on brain activation in neural networks supporting digit working memory tasks. Participants activating frontal-parietal networks responded faster than individuals relying more on language-related brain networks.There were genetic influences on brain activation in language-relevant brain circuits that were atypical for numerical working memory tasks as such. This suggests that differences in cognition might be related to brain activation patterns that differ qualitatively among individuals.
  • De Kovel, C. G. F., Mulder, F., van Setten, J., van 't Slot, R., Al-Rubaish, A., Alshehri, A. M., Al Faraidy, K., Al-Ali, A., Al-Madan, M., Al Aqaili, I., Larbi, E., Al-Ali, R., Alzahrani, A., Asselbergs, F. W., Koeleman, B. P., & Al-Ali, A. (2016). Exome-Wide Association Analysis of Coronary Artery Disease in the Kingdom of Saudi Arabia Population. PLoS One, 11(2), e0146502. doi:10.1371/journal.pone.0146502.

    Abstract

    Coronary Artery Disease (CAD) remains the leading cause of mortality worldwide. Mortality rates associated with CAD have shown an exceptional increase particularly in fast developing economies like the Kingdom of Saudi Arabia (KSA). Over the past twenty years, CAD has become the leading cause of death in KSA and has reached epidemic proportions. This rise is undoubtedly caused by fast urbanization that is associated with a life-style that promotes CAD. However, the question remains whether genetics play a significant role and whether genetic susceptibility is increased in KSA compared to the well-studied Western European populations. Therefore, we performed an Exome-wide association study (EWAS) in 832 patients and 1,076 controls of Saudi Arabian origin to test whether population specific, strong genetic risk factors for CAD exist, or whether the polygenic risk score for known genetic risk factors for CAD, lipids, and Type 2 Diabetes show evidence for an enriched genetic burden. Our results do not show significant associations for a single genetic locus. However, the heritability estimate for CAD for this population was high (h2 = 0.53, S.E. = 0.1, p = 4e-12) and we observed a significant association of the polygenic risk score for CAD that demonstrates that the population of KSA, at least in part, shares the genetic risk associated to CAD in Western populations.

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    Data Availability
  • De Kovel, C. G. F., Brilstra, E. H., van Kempen, M. J., Van't Slot, R., Nijman, I. J., Afawi, Z., De Jonghe, P., Djemie, T., Guerrini, R., Hardies, K., Helbig, I., Hendrickx, R., Kanaan, M., Kramer, U., Lehesjoki, A. E., Lemke, J. R., Marini, C., Mei, D., Moller, R. S., Pendziwiat, M. and 4 moreDe Kovel, C. G. F., Brilstra, E. H., van Kempen, M. J., Van't Slot, R., Nijman, I. J., Afawi, Z., De Jonghe, P., Djemie, T., Guerrini, R., Hardies, K., Helbig, I., Hendrickx, R., Kanaan, M., Kramer, U., Lehesjoki, A. E., Lemke, J. R., Marini, C., Mei, D., Moller, R. S., Pendziwiat, M., Stamberger, H., Suls, A., Weckhuysen, S., & Koeleman, B. P. (2016). Targeted sequencing of 351 candidate genes for epileptic encephalopathy in a large cohort of patients. Molecular Genetics & Genomic Medicine, 4(5), 568-80. doi:10.1002/mgg3.235.

    Abstract

    Background Many genes are candidates for involvement in epileptic encephalopathy (EE) because one or a few possibly pathogenic variants have been found in patients, but insufficient genetic or functional evidence exists for a definite annotation. Methods To increase the number of validated EE genes, we sequenced 26 known and 351 candidate genes for EE in 360 patients. Variants in 25 genes known to be involved in EE or related phenotypes were followed up in 41 patients. We pri- oritized the candidate genes, and followed up 31 variants in this prioritized subset of candidate genes. Results Twenty-nine genotypes in known genes for EE (19) or related diseases (10), dominant as well as recessive or X-linked, were classified as likely pathogenic variants. Among those, likely pathogenic de novo variants were found in EE genes that act dominantly, including the recently identified genes EEF1A2, KCNB1 and the X-linked gene IQSEC2 .A de novo frameshift variant in candi- date gene HNRNPU was the only de novo variant found among the followed- up candidate genes, and the patient’s phenotype was similar to a few recent publication
  • Krämer, I. (1998). Children's interpretations of indefinite object noun phrases. Linguistics in the Netherlands, 1998, 163-174. doi:10.1075/avt.15.15kra.
  • Kroes, H. Y., Monroe, G. R., van der Zwaag, B., Duran, K. J., De Kovel, C. G. F., van Roosmalen, M. J., Harakalova, M., Nijman, I. J., Kloosterman, W. P., Giles, R. H., Knoers, N. V., & van Haaften, G. (2016). Joubert syndrome: genotyping a Northern European patient cohort. European Journal of Human Genetics, 24(2), 214-20. doi:10.1038/ejhg.2015.84.
  • Krott, A., Hagoort, P., & Baayen, R. H. (2004). Sublexical units and supralexical combinatories in the processing of interfixed Dutch compounds. Language and Cognitive Processes, 19(3), 453-471. doi:10.1080/769813936.

    Abstract

    This study addresses the supralexical inferential processes underlying wellformedness judgements and latencies for a specic sublexical unit that appears in Dutch compounds, the interfix. Production studies have shown that the selection of interfixes in novel Dutch compounds and the speed of
    this selection is primarily determined by the distribution of interfixes in existing compounds that share the left constituent with the target compound, i.e. the ‘‘left constituent family’’. In this paper, we consider the question whether constituent families also affect wellformedness decisions of novel as well as existing Dutch compounds in comprehension. We visually presented compounds containing interfixes that were either in line with the bias of the left constituent family or not. In the case of existing compounds, we also presented variants with replaced interfixes. As in production, the bias of the left constituent family emerged as a crucial predictor for both acceptance rates and response latencies. This result supports the hypothesis that, as in production, constituent families are (co-)activated in comprehension. We argue that this co-activation is part of a supralexical inferential process, and we discuss how our data might be interpreted within sublexical and supralexical theories of morphological processing.
  • Krott, A., Libben, G., Jarema, G., Dressler, W., Schreuder, R., & Baayen, R. H. (2004). Probability in the grammar of German and Dutch: Interfixation in triconstituent compounds. Language and Speech, 47(1), 83-106.

    Abstract

    This study addresses the possibility that interfixes in multiconstituent nominal compounds in German and Dutch are functional as markers of immediate constituent structure.We report a lexical statistical survey of interfixation in the lexicons of German and Dutch which shows that all interfixes of German and one interfix of Dutch are significantly more likely to appear at the major constituent boundary than expected under chance conditions. A series of experiments provides evidence that speakers of German and Dutch are sensitive to the probabilistic cues to constituent structure provided by the interfixes. Thus, our data provide evidence that probability is part and parcel of grammatical competence.
  • Krott, A., Baayen, R. H., & Hagoort, P. (2006). The nature of anterior negativities caused by misapplications of morphological rules. Journal of Cognitive Neuroscience, 18(10), 1616-1630. doi:10.1162/jocn.2006.18.10.1616.

    Abstract

    This study investigates functional interpretations of left
    anterior negativities (LANs), a language-related electroencephalogram effect that has been found for syntactic and morphological violations. We focus on three possible interpretations of LANs caused by the replacement of irregular affixes with regular affixes: misapplication of morphological rules, mismatch of the presented form with analogy-based expectations, and mismatch of the presented form with stored representations. Event-related brain potentials were recorded during the visual presentation of existing and novel Dutch compounds. Existing compounds contained correct or replaced interfixes (dame + s + salons > damessalons vs. *dame + n + salons > *damensalons ‘‘women’s hairdresser salons’’), whereas novel Dutch compounds contained interfixes that were either supported or not supported by analogy to similar existing compounds
    (kruidenkelken vs. ?kruidskelken ‘‘herb chalices’’); earlier studies had shown that interfixes are selected by analogy instead of rules. All compounds were presented with correct or incorrect regular plural suffixes (damessalons vs. *damessalonnen). Replacing suffixes or interfixes in existing compounds both led to increased (L)ANs between 400 and 700 msec without any evidence for different scalp distributions for interfixes and suffixes. There was no evidence for a negativity when manipulating the analogical support for interfixes in novel compounds. Together with earlier studies, these results suggest that LANs had been caused by the mismatch of the presented forms with stored forms. We discuss these findings with respect to the single/dual-route debate of morphology and LANs found for the misapplication of syntactic rules.
  • Kuggeleijn, J., & De Ruiter, J. P. (2006). Met de angst in de pen: Waarom ambtenaren zo merkwaardig schrijven. Onze Taal, 75(9), 236-237.
  • Kulakova, E., & Nieuwland, M. S. (2016). Pragmatic skills predict online counterfactual comprehension: Evidence from the N400. Cognitive, Affective and Behavioral Neuroscience, 16(5), 814-824. doi:10.3758/s13415-016-0433-4.

    Abstract

    Counterfactual thought allows people to consider alternative worlds they know to be false. Communicating these thoughts through language poses a social-communicative challenge because listeners typically expect a speaker to produce true utterances, but counterfactuals per definition convey information that is false. Listeners must therefore incorporate overt linguistic cues (subjunctive mood, such as in If I loved you then) in a rapid way to infer the intended counterfactual meaning. The present EEG study focused on the comprehension of such counterfactual antecedents and investigated if pragmatic ability—the ability to apply knowledge of the social-communicative use of language in daily life—predicts the online generation of counterfactual worlds. This yielded two novel findings: (1) Words that are consistent with factual knowledge incur a semantic processing cost, as reflected in larger N400 amplitude, in counterfactual antecedents compared to hypothetical antecedents (If sweets were/are made of sugar). We take this to suggest that counterfactuality is quickly incorporated during language comprehension and reduces online expectations based on factual knowledge. (2) Individual scores on the Autism Quotient Communication subscale modulated this effect, suggesting that individuals who are better at understanding the communicative intentions of other people are more likely to reduce knowledge-based expectations in counterfactuals. These results are the first demonstration of the real-time pragmatic processes involved in creating possible worlds.
  • Kulakova, E., & Nieuwland, M. S. (2016). Understanding Counterfactuality: A Review of Experimental Evidence for the Dual Meaning of Counterfactuals. Language and Linguistics Compass, 10(2), 49-65. doi:10.1111/lnc3.12175.

    Abstract

    Cognitive and linguistic theories of counterfactual language comprehension assume that counterfactuals convey a dual meaning. Subjunctive-counterfactual conditionals (e.g., ‘If Tom had studied hard, he would have passed the test’) express a supposition while implying the factual state of affairs (Tom has not studied hard and failed). The question of how counterfactual dual meaning plays out during language processing is currently gaining interest in psycholinguistics. Whereas numerous studies using offline measures of language processing consistently support counterfactual dual meaning, evidence coming from online studies is less conclusive. Here, we review the available studies that examine online counterfactual language comprehension through behavioural measurement (self-paced reading times, eye-tracking) and neuroimaging (electroencephalography, functional magnetic resonance imaging). While we argue that these studies do not offer direct evidence for the online computation of counterfactual dual meaning, they provide valuable information about the way counterfactual meaning unfolds in time and influences successive information processing. Further advances in research on counterfactual comprehension require more specific predictions about how counterfactual dual meaning impacts incremental sentence processing.
  • Kunert, R., Willems, R. M., & Hagoort, P. (2016). An independent psychometric evaluation of the PROMS measure of music perception skills. PLoS One, 11(7): e0159103. doi:10.1371/journal.pone.0159103.

    Abstract

    The Profile of Music Perception Skills (PROMS) is a recently developed measure of perceptual music skills which has been shown to have promising psychometric properties. In this paper we extend the evaluation of its brief version to three kinds of validity using an individual difference approach. The brief PROMS displays good discriminant validity with working memory, given that it does not correlate with backward digit span (r = .04). Moreover, it shows promising criterion validity (association with musical training (r = .45), musicianship status (r = .48), and self-rated musical talent (r = .51)). Finally, its convergent validity, i.e. relation to an unrelated measure of music perception skills, was assessed by correlating the brief PROMS to harmonic closure judgment accuracy. Two independent samples point to good convergent validity of the brief PROMS (r = .36; r = .40). The same association is still significant in one of the samples when including self-reported music skill in a partial correlation (rpartial = .30; rpartial = .17). Overall, the results show that the brief version of the PROMS displays a very good pattern of construct validity. Especially its tuning subtest stands out as a valuable part for music skill evaluations in Western samples. We conclude by briefly discussing the choice faced by music cognition researchers between different musical aptitude measures of which the brief PROMS is a well evaluated example.
  • Kunert, R., Willems, R. M., & Hagoort, P. (2016). Language influences music harmony perception: effects of shared syntactic integration resources beyond attention. Royal Society Open Science, 3(2): 150685. doi:10.1098/rsos.150685.

    Abstract

    Many studies have revealed shared music–language processing resources by finding an influence of music harmony manipulations on concurrent language processing. However, the nature of the shared resources has remained ambiguous. They have been argued to be syntax specific and thus due to shared syntactic integration resources. An alternative view regards them as related to general attention and, thus, not specific to syntax. The present experiments evaluated these accounts by investigating the influence of language on music. Participants were asked to provide closure judgements on harmonic sequences in order to assess the appropriateness of sequence endings. At the same time participants read syntactic garden-path sentences. Closure judgements revealed a change in harmonic processing as the result of reading a syntactically challenging word. We found no influence of an arithmetic control manipulation (experiment 1) or semantic garden-path sentences (experiment 2). Our results provide behavioural evidence for a specific influence of linguistic syntax processing on musical harmony judgements. A closer look reveals that the shared resources appear to be needed to hold a harmonic key online in some form of syntactic working memory or unification workspace related to the integration of chords and words. Overall, our results support the syntax specificity of shared music–language processing resources.
  • Kunert, R. (2016). Internal conceptual replications do not increase independent replication success. Psychonomic Bulletin & Review, 23(5), 1631-1638. doi:10.3758/s13423-016-1030-9.

    Abstract

    Recently, many psychological effects have been surprisingly difficult to reproduce. This article asks why, and investigates whether conceptually replicating an effect in the original publication is related to the success of independent, direct replications. Two prominent accounts of low reproducibility make different predictions in this respect. One account suggests that psychological phenomena are dependent on unknown contexts that are not reproduced in independent replication attempts. By this account, internal replications indicate that a finding is more robust and, thus, that it is easier to independently replicate it. An alternative account suggests that researchers employ questionable research practices (QRPs), which increase false positive rates. By this account, the success of internal replications may just be the result of QRPs and, thus, internal replications are not predictive of independent replication success. The data of a large reproducibility project support the QRP account: replicating an effect in the original publication is not related to independent replication success. Additional analyses reveal that internally replicated and internally unreplicated effects are not very different in terms of variables associated with replication success. Moreover, social psychological effects in particular appear to lack any benefit from internal replications. Overall, these results indicate that, in this dataset at least, the influence of QRPs is at the heart of failures to replicate psychological findings, especially in social psychology. Variable, unknown contexts appear to play only a relatively minor role. I recommend practical solutions for how QRPs can be avoided.

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  • Küntay, A. C., & Ozyurek, A. (2006). Learning to use demonstratives in conversation: What do language specific strategies in Turkish reveal? Journal of Child Language, 33(2), 303-320. doi:10.1017/S0305000906007380.

    Abstract

    Pragmatic development requires the ability to use linguistic forms, along with non-verbal cues, to focus an interlocutor's attention on a referent during conversation. We investigate the development of this ability by examining how the use of demonstratives is learned in Turkish, where a three-way demonstrative system (bu, su, o) obligatorily encodes both distance contrasts (i.e. proximal and distal) and absence or presence of the addressee's visual attention on the referent. A comparison of the demonstrative use by Turkish children (6 four- and 6 six-year-olds) and 6 adults during conversation shows that adultlike use of attention directing demonstrative, su, is not mastered even at the age of six, while the distance contrasts are learned earlier. This language specific development reveals that designing referential forms in consideration of recipient's attentional status during conversation is a pragmatic feat that takes more than six years to develop.
  • Kurt, S., Groszer, M., Fisher, S. E., & Ehret, G. (2009). Modified sound-evoked brainstem potentials in Foxp2 mutant mice. Brain Research, 1289, 30-36. doi:10.1016/j.brainres.2009.06.092.

    Abstract

    Heterozygous mutations of the human FOXP2 gene cause a developmental disorder involving impaired learning and production of fluent spoken language. Previous investigations of its aetiology have focused on disturbed function of neural circuits involved in motor control. However, Foxp2 expression has been found in the cochlea and auditory brain centers and deficits in auditory processing could contribute to difficulties in speech learning and production. Here, we recorded auditory brainstem responses (ABR) to assess two heterozygous mouse models carrying distinct Foxp2 point mutations matching those found in humans with FOXP2-related speech/language impairment. Mice which carry a Foxp2-S321X nonsense mutation, yielding reduced dosage of Foxp2 protein, did not show systematic ABR differences from wildtype littermates. Given that speech/language disorders are observed in heterozygous humans with similar nonsense mutations (FOXP2-R328X), our findings suggest that auditory processing deficits up to the midbrain level are not causative for FOXP2-related language impairments. Interestingly, however, mice harboring a Foxp2-R552H missense mutation displayed systematic alterations in ABR waves with longer latencies (significant for waves I, III, IV) and smaller amplitudes (significant for waves I, IV) suggesting that either the synchrony of synaptic transmission in the cochlea and in auditory brainstem centers is affected, or fewer auditory nerve fibers and fewer neurons in auditory brainstem centers are activated compared to wildtypes. Therefore, the R552H mutation uncovers possible roles for Foxp2 in the development and/or function of the auditory system. Since ABR audiometry is easily accessible in humans, our data call for systematic testing of auditory functions in humans with FOXP2 mutations.
  • Lai, V. T., & Huettig, F. (2016). When prediction is fulfilled: Insight from emotion processing. Neuropsychologia, 85, 110-117. doi:10.1016/j.neuropsychologia.2016.03.014.

    Abstract

    Research on prediction in language processing has focused predominantly on the function of predictive context and less on the potential contribution of the predicted word. The present study investigated how meaning that is not immediately prominent in the contents of predictions but is part of the predicted words influences sentence processing. We used emotional meaning to address this question. Participants read emotional and neutral words embedded in highly predictive and non-predictive sentential contexts, with the two sentential contexts rated similarly for their emotional ratings. Event Related Potential (ERP) effects of prediction and emotion both started at ~200 ms. Confirmed predictions elicited larger P200s than violated predictions when the target words were non-emotional (neutral), but such effect was absent when the target words were emotional. Likewise, emotional words elicited larger P200s than neutral words when the target words were non-predictive, but such effect were absent when the contexts were predictive. We conjecture that the prediction and emotion effects at ~200 ms may share similar neural process(es). We suggest that such process(es) could be affective, where confirmed predictions and word emotion give rise to ‘aha’ or reward feelings, and/or cognitive, where both prediction and word emotion quickly engage attention

    Additional information

    Lai_Huettig_2016_supp.xlsx
  • Lai, V. T., Curran, T., & Menn, L. (2009). Comprehending conventional and novel metaphors: An ERP study. Brain Research, 1284, 145-155. doi:10.1016/j.brainres.2009.05.088.
  • Lam, N. H. L., Schoffelen, J.-M., Udden, J., Hulten, A., & Hagoort, P. (2016). Neural activity during sentence processing as reflected in theta, alpha, beta and gamma oscillations. NeuroImage, 142(15), 43-54. doi:10.1016/j.neuroimage.2016.03.007.

    Abstract

    We used magnetoencephalography (MEG) to explore the spatio-temporal dynamics of neural oscillations associated with sentence processing, in 102 participants. We quantified changes in oscillatory power as the sentence unfolded, and in response to individual words in the sentence. For words early in a sentence compared to those late in the same sentence, we observed differences in left temporal and frontal areas, and bilateral frontal and right parietal regions for the theta, alpha, and beta frequency bands. The neural response to words in a sentence differed from the response to words in scrambled sentences in left-lateralized theta, alpha, beta, and gamma. The theta band effects suggest that a sentential context facilitates lexical retrieval, and that this facilitation is stronger for words late in the sentence. Effects in the alpha and beta band may reflect the unification of semantic and syntactic information, and are suggestive of easier unification late in a sentence. The gamma oscillations are indicative of predicting the upcoming word during sentence processing. In conclusion, changes in oscillatory neuronal activity capture aspects of sentence processing. Our results support earlier claims that language (sentence) processing recruits areas distributed across both hemispheres, and extends beyond the classical language regions
  • de Lange, I. M., Helbig, K. L., Weckhuysen, S., Moller, R. S., Velinov, M., Dolzhanskaya, N., Marsh, E., Helbig, I., Devinsky, O., Tang, S., Mefford, H. C., Myers, C. T., van Paesschen, W., Striano, P., van Gassen, K., van Kempen, M., De Kovel, C. G. F., Piard, J., Minassian, B. A., Nezarati, M. M. and 12 morede Lange, I. M., Helbig, K. L., Weckhuysen, S., Moller, R. S., Velinov, M., Dolzhanskaya, N., Marsh, E., Helbig, I., Devinsky, O., Tang, S., Mefford, H. C., Myers, C. T., van Paesschen, W., Striano, P., van Gassen, K., van Kempen, M., De Kovel, C. G. F., Piard, J., Minassian, B. A., Nezarati, M. M., Pessoa, A., Jacquette, A., Maher, B., Balestrini, S., Sisodiya, S., Warde, M. T., De St Martin, A., Chelly, J., van 't Slot, R., Van Maldergem, L., Brilstra, E. H., & Koeleman, B. P. (2016). De novo mutations of KIAA2022 in females cause intellectual disability and intractable epilepsy. Journal of Medical Genetics, 53(12), 850-858. doi:10.1136/jmedgenet-2016-103909.

    Abstract

    Background Mutations in the KIAA2022 gene have been reported in male patients with X-linked intellectual disability, and related female carriers were unaffected. Here, we report 14 female patients who carry a heterozygous de novo KIAA2022 mutation and share a phenotype characterised by intellectual disability and epilepsy.

    Methods Reported females were selected for genetic testing because of substantial developmental problems and/or epilepsy. X-inactivation and expression studies were performed when possible.

    Results All mutations were predicted to result in a frameshift or premature stop. 12 out of 14 patients had intractable epilepsy with myoclonic and/or absence seizures, and generalised in 11. Thirteen patients had mild to severe intellectual disability. This female phenotype partially overlaps with the reported male phenotype which consists of more severe intellectual disability, microcephaly, growth retardation, facial dysmorphisms and, less frequently, epilepsy. One female patient showed completely skewed X-inactivation, complete absence of RNA expression in blood and a phenotype similar to male patients. In the six other tested patients, X-inactivation was random, confirmed by a non-significant twofold to threefold decrease of RNA expression in blood, consistent with the expected mosaicism between cells expressing mutant or normal KIAA2022 alleles.

    Conclusions Heterozygous loss of KIAA2022 expression is a cause of intellectual disability in females. Compared with its hemizygous male counterpart, the heterozygous female disease has less severe intellectual disability, but is more often associated with a severe and intractable myoclonic epilepsy.
  • De Lange, F. P., Kalkman, J. S., Bleijenberg, G., Hagoort, P., Van der Werf, S. P., Van der Meer, J. W. M., & Toni, I. (2004). Neural correlates of the chronic fatigue syndrom: An fMRI study. Brain, 127(9), 1948-1957. doi:10.1093/brain/awh225.

    Abstract

    Chronic fatigue syndrome (CFS) is characterized by a debilitating fatigue of unknown aetiology. Patients who suffer from CFS report a variety of physical complaints as well as neuropsychological complaints. Therefore, it is conceivable that the CNS plays a role in the pathophysiology of CFS. The purpose of this study was to investigate neural correlates of CFS, and specifically whether there exists a linkage between disturbances in the motor system and CFS. We measured behavioural performance and cerebral activity using rapid event-related functional MRI in 16 CFS patients and 16 matched healthy controls while they were engaged in a motor imagery task and a control visual imagery task. CFS patients were considerably slower on performance of both tasks, but the increase in reaction time with increasing task load was similar between the groups. Both groups used largely overlapping neural resources. However, during the motor imagery task, CFS patients evoked stronger responses in visually related structures. Furthermore, there was a marked between-groups difference during erroneous performance. In both groups, dorsal anterior cingulate cortex was specifically activated during error trials. Conversely, ventral anterior cingulate cortex was active when healthy controls made an error, but remained inactive when CFS patients made an error. Our results support the notion that CFS may be associated with dysfunctional motor planning. Furthermore, the between-groups differences observed during erroneous performance point to motivational disturbances as a crucial component of CFS.
  • De Lange, F. P., Koers, A., Kalkman, J. S., Bleijenberg, G., Hagoort, P., Van der Meer, J. W. M., & Toni, I. (2009). Reply to: "Can CBT substantially change grey matter volume in chronic fatigue syndrome" [Letter to the editor]. Brain, 132(6), e111. doi:10.1093/brain/awn208.
  • De Lange, F., Bleijenberg, G., Van der Meer, J. W. M., Hagoort, P., & Toni, I. (2009). Reply: Change in grey matter volume cannot be assumed to be due to cognitive behavioural therapy [Letter to the editor]. Brain, 132(7), e120. doi:10.1093/brain/awn359.
  • De Lange, F. P., Knoop, H., Bleijenberg, G., Van der Meer, J. W. M., Hagoort, P., & Toni, I. (2009). The experience of fatigue in the brain [Letter to the editor]. Psychological Medicine, 39, 523-524. doi:10.1017/S0033291708004844.
  • Lattenkamp, E. Z., Mandák, M., & Scherz, M. D. (2016). The advertisement call of Stumpffia be Köhler, Vences, D'Cruze & Glaw, 2010 (Anura: Microhylidae: Cophylinae). Zootaxa, 4205(5), 483-485. doi:10.11646/zootaxa.4205.5.7.

    Abstract

    We describe the calls of Stumpffia be Köhler, Vences, D’Cruze & Glaw, 2010. This is the first call description made for a species belonging to the large-bodied northern Madagascan radiation of Stumpffia Boettger, 1881. Stumpffia is a genus of small (~9–28 mm) microhylid frogs in the Madagascar-endemic subfamily Cophylinae Cope. Little is known about their reproductive strategies. Most species are assumed to lay their eggs in foam nests in the leaf litter of Madagascar’s humid and semi-humid forests (Glaw & Vences 1994; Klages et al. 2013). They exhibit some degree of parental care, with the males guarding the nest after eggs are laid (Klages et al. 2013). The bioacoustic repertoire of these frogs is thought to be limited, and there are two distinct call structures known for the genus: the advertisement call of the type species, S. psologlossa Boettger, 1881, is apparently unique in being a trill of notes repeated in short succession. All other species from which calls are known emit single, whistling or chirping notes (Vences & Glaw 1991; Vences et al. 2006).

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